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hippo follicle

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https://www.readbyqxmd.com/read/27505353/the-hippo-mst-pathway-member-sav1-plays-a-suppressive-role-in-development-of-the-prehierarchical-follicles-in-hen-ovary
#1
Zhichao Lyu, Ning Qin, Thobela Louis Tyasi, Hongyan Zhu, Dehui Liu, Shuguo Yuan, Rifu Xu
The Hippo/MST signaling pathway is a critical player in controlling cell proliferation, self-renewal, differentiation, and apoptosis of most tissues and organs in diverse species. Previous studies have shown that Salvador homolog 1 (SAV1), a scaffolding protein which functions in the signaling system is expressed in mammalian ovaries and play a vital role in governing the follicle development. But the exact biological effects of chicken SAV1 in prehierarchical follicle development remain poorly understood. In the present study, we demonstrated that the SAV1 protein is predominantly expressed in the oocytes and undifferentiated granulosa cells in the various sized prehierarchical follicles of hen ovary, and the endogenous expression level of SAV1 mRNA appears down-regulated from the primordial follicles to the largest preovulatory follicles (F2-F1) by immunohistochemistry and real-time RT-PCR, respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27474441/oncogenic-transformation-of-drosophila-somatic-cells-induces-a-functional-pirna-pathway
#2
Delphine Fagegaltier, Ilaria Falciatori, Benjamin Czech, Stephane Castel, Norbert Perrimon, Amanda Simcox, Gregory J Hannon
Germline genes often become re-expressed in soma-derived human cancers as "cancer/testis antigens" (CTAs), and piRNA (PIWI-interacting RNA) pathway proteins are found among CTAs. However, whether and how the piRNA pathway contributes to oncogenesis in human neoplasms remain poorly understood. We found that oncogenic Ras combined with loss of the Hippo tumor suppressor pathway reactivates a primary piRNA pathway in Drosophila somatic cells coincident with oncogenic transformation. In these cells, Piwi becomes loaded with piRNAs derived from annotated generative loci, which are normally restricted to either the germline or the somatic follicle cells...
July 15, 2016: Genes & Development
https://www.readbyqxmd.com/read/27402810/regulation-of-hippo-signalling-by-p38-signalling
#3
Dashun Huang, Xiaojiao Li, Li Sun, Ping Huang, Hao Ying, Hui Wang, Jiarui Wu, Haiyun Song
The Hippo signalling pathway has a crucial role in growth control during development, and its dysregulation contributes to tumorigenesis. Recent studies uncover multiple upstream regulatory inputs into Hippo signalling, which affects phosphorylation of the transcriptional coactivator Yki/YAP/TAZ by Wts/Lats. Here we identify the p38 mitogen-activated protein kinase (MAPK) pathway as a new upstream branch of the Hippo pathway. In Drosophila, overexpression of MAPKK gene licorne (lic), or MAPKKK gene Mekk1, promotes Yki activity and induces Hippo target gene expression...
August 2016: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/27022685/activation-of-dormant-follicles-a-new-treatment-for-premature-ovarian-failure
#4
Kazuhiro Kawamura, Nanami Kawamura, Aaron J W Hsueh
PURPOSE OF REVIEW: Premature ovarian failure (POF) is diagnosed by amenorrhea before 40 years of age. Owing to exhaustion of follicles in POF ovaries, egg donation is the only option. Although menstrual cycles cease in POF patients, some of them still contain residual dormant follicles in ovaries. Recently, we developed a new infertility treatment and named it as in-vitro activation (IVA), which enables POF patients to conceive using their own eggs by activation of residual dormant follicles...
June 2016: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26183517/ovarian-germline-stem-cells-ogscs-and-the-hippo-signaling-pathway-association-with-physiological-and-pathological-ovarian-aging-in-mice
#5
Jia Li, Fangyue Zhou, Tuochen Zheng, Zezheng Pan, Xia Liang, Jian Huang, Liping Zheng, Yuehui Zheng
BACKGROUND: The Hippo signaling pathway plays fundamental roles in stem cell maintenance in a variety of tissues and has thus implications for stem cell biology. Key components of this recently discovered pathway have been shown to be associated with primordial follicle activation. However, whether the Hippo signaling pathway plays a role in the development of Ovarian Germline Stem Cells (OGSCs) during physiological and pathological ovarian aging in mice is unknown. METHODS: Mice at the age of 7 days (7D), or of 2, 10, or 20 months (2M, 10M, 20M) and mice at 2M treated with TPT and CY/BUS drugs were selected as physiological and pathological ovarian aging models, respectively...
2015: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/26040669/lats1-deletion-causes-increased-germ-cell-apoptosis-and-follicular-cysts-in-mouse-ovaries
#6
Tianyanxin Sun, Melissa E Pepling, Francisco J Diaz
The Hippo signaling pathway is essential for regulating proliferation and apoptosis in mammalian cells. The LATS1 kinase is a core member of the Hippo signaling pathway that phosphorylates and inactivates the transcriptional co-activators YAP1 and WWTR1. Deletion of Lats1 results in low neonate survival and ovarian stromal tumors in surviving adults, but the effects of Lats1 on early follicular development are not understood. Here, the expression of Hippo pathway components including Wwtr1, Stk4, Stk3, Lats2, and Yap1 transcripts were decreased by 50% in mouse ovaries between 2 and 8 days of age while expression was maintained from 8 days to 21 days and after priming with eCG...
July 2015: Biology of Reproduction
https://www.readbyqxmd.com/read/25961504/inactivation-of-a-g%C3%AE-s-pka-tumour-suppressor-pathway-in-skin-stem-cells-initiates-basal-cell-carcinogenesis
#7
Ramiro Iglesias-Bartolome, Daniela Torres, Romina Marone, Xiaodong Feng, Daniel Martin, May Simaan, Min Chen, Lee S Weinstein, Susan S Taylor, Alfredo A Molinolo, J Silvio Gutkind
Genomic alterations in GNAS, the gene coding for the Gαs heterotrimeric G protein, are associated with a large number of human diseases. Here, we explored the role of Gαs on stem cell fate decisions by using the mouse epidermis as a model system. Conditional epidermal deletion of Gnas or repression of PKA signalling caused a remarkable expansion of the stem cell compartment, resulting in rapid basal-cell carcinoma formation. In contrast, inducible expression of active Gαs in the epidermis caused hair follicle stem cell exhaustion and hair loss...
June 2015: Nature Cell Biology
https://www.readbyqxmd.com/read/25907767/crosstalk-of-egfr-signalling-with-notch-and-hippo-pathways-to-regulate-cell-specification-migration-and-proliferation-in-cockroach-panoistic-ovaries
#8
Nashwa Elshaer, Maria-Dolors Piulachs
BACKGROUND INFORMATION: Epidermal growth factor receptor (EGFR) signalling is crucial for the regulation of multiple developmental processes. Its function in relation to insect oogenesis has been thoroughly studied in the fly Drosophila melanogaster, which possesses ovaries of the highly modified meroistic type. Conversely, studies in other insect species with different ovary types are scarce. We have studied EGFR functions in the oogenesis of the cockroach Blattella germanica, a phylogenetically basal insect with panoistic ovaries...
August 2015: Biology of the Cell
https://www.readbyqxmd.com/read/25712476/the-spectrin-cytoskeleton-regulates-the-hippo-signalling-pathway
#9
Georgina C Fletcher, Ahmed Elbediwy, Ichha Khanal, Paulo S Ribeiro, Nic Tapon, Barry J Thompson
The Spectrin cytoskeleton is known to be polarised in epithelial cells, yet its role remains poorly understood. Here, we show that the Spectrin cytoskeleton controls Hippo signalling. In the developing Drosophila wing and eye, loss of apical Spectrins (alpha/beta-heavy dimers) produces tissue overgrowth and mis-regulation of Hippo target genes, similar to loss of Crumbs (Crb) or the FERM-domain protein Expanded (Ex). Apical beta-heavy Spectrin binds to Ex and co-localises with it at the apical membrane to antagonise Yki activity...
April 1, 2015: EMBO Journal
https://www.readbyqxmd.com/read/25690654/actin-polymerization-enhancing-drugs-promote-ovarian-follicle-growth-mediated-by-the-hippo-signaling-effector-yap
#10
Yuan Cheng, Yi Feng, Lina Jansson, Yorino Sato, Masashi Deguchi, Kazuhiro Kawamura, Aaron J Hsueh
Hippo signaling pathway consists of conserved serine/threonine kinases to maintain optimal organ sizes. Studies have demonstrated that fragmentation of murine ovaries increases actin polymerization and disrupts Hippo signaling, leading to nuclear translocation of Hippo signaling effector Yes-associated protein (YAP) in ovarian follicles and follicle growth. For patients with polycystic ovarian syndrome showing follicle arrest, ovarian wedge resection and laser drilling promote follicle growth. Because these damaging procedures likely involve actin polymerization, we tested whether actin polymerization-promoting drugs could promote YAP translocation and stimulate follicle growth...
June 2015: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/25659841/hippo-signaling-pathway-reveals-a-spatio-temporal-correlation-with-the-size-of-primordial-follicle-pool-in-mice
#11
Cheng Xiang, Jia Li, Liaoliao Hu, Jian Huang, Tao Luo, Zhisheng Zhong, Yuehui Zheng, Liping Zheng
BACKGROUND: The Hippo signaling pathway, a highly conserved cell signaling system, exists in most multicellular organisms and regulates cell proliferation, differentiation, and apoptosis. It has been reported that the members of Hippo signaling are expressed in mammalian ovaries, but the exact functions of this pathway in primordial follicle development remains unclear. METHODS: To analyze the spatio-temporal correlation between the core component of Hippo pathway and the size of primordial follicle pool, Western blot, Real-time PCR and immunohistochemistry were used, and the expression and localization of MST1, LATS2 and YAP1 mRNA and protein were examined in 3 d, 1 m, 5 m, 16 m postnatal mice ovary and the culture model of mice primordial follicle in vitro...
2015: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/25589787/%C3%AE-spectrin-regulates-the-hippo-signaling-pathway-and-modulates-the-basal-actin-network
#12
Kenneth Kin Lam Wong, Wenyang Li, Yanru An, Yangyang Duan, Zhuoheng Li, Yibin Kang, Yan Yan
Emerging evidence suggests functional regulation of the Hippo pathway by the actin cytoskeleton, although the detailed molecular mechanism remains incomplete. In a genetic screen, we identified a requirement for β-Spectrin in the posterior follicle cells for the oocyte repolarization process during Drosophila mid-oogenesis. β-spectrin mutations lead to loss of Hippo signaling activity in the follicle cells. A similar reduction of Hippo signaling activity was observed after β-Spectrin knockdown in mammalian cells...
March 6, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/25567618/successful-fertility-preservation-following-ovarian-tissue-vitrification-in-patients-with-primary-ovarian-insufficiency
#13
Nao Suzuki, Nobuhito Yoshioka, Seido Takae, Yodo Sugishita, Midori Tamura, Shu Hashimoto, Yoshiharu Morimoto, Kazuhiro Kawamura
STUDY QUESTION: Is ovarian tissue cryopreservation using vitrification followed by in vitro activation (IVA) of dormant follicles a potential approach for infertility treatment of patients with primary ovarian insufficiency (POI)? SUMMARY ANSWER: Our vitrification approach followed by IVA treatment is a potential infertility therapy for POI patients whose ovaries contain residual follicles. WHAT IS KNOWN ALREADY: Akt (protein kinase B) stimulators [PTEN (phosphatase with TENsin homology deleted in chromosome 10) inhibitor and phosphatidyinositol-3-kinase (PI3 kinase) stimulator] activate dormant primordial follicles in vitro and ovarian fragmentation disrupts the Hippo signaling pathway, leading to the promotion of follicle growth...
March 2015: Human Reproduction
https://www.readbyqxmd.com/read/25426635/unlike-in-drosophila-meroistic-ovaries-hippo-represses-notch-in-blattella-germanica-panoistic-ovaries-triggering-the-mitosis-endocycle-switch-in-the-follicular-cells
#14
Paula Irles, Maria-Dolors Piulachs
During insect oogenesis, the follicular epithelium undergoes both cell proliferation and apoptosis, thus modulating ovarian follicle growth. The Hippo pathway is key in these processes, and has been thoroughly studied in the meroistic ovaries of Drosophila melanogaster. However, nothing is known about the role of the Hippo pathway in primitive panoistic ovaries. This work examines the mRNA expression levels of the main components of the Hippo pathway in the panoistic ovary of the basal insect species Blattella germanica, and demonstrates the function of Hippo through RNAi...
2014: PloS One
https://www.readbyqxmd.com/read/25202833/intraovarian-control-of-early-folliculogenesis
#15
REVIEW
Aaron J W Hsueh, Kazuhiro Kawamura, Yuan Cheng, Bart C J M Fauser
Although hormonal regulation of ovarian follicle development has been extensively investigated, most studies concentrate on the development of early antral follicles to the preovulatory stage, leading to the successful use of exogenous FSH for infertility treatment. Accumulating data indicate that preantral follicles are under stringent regulation by FSH and local intraovarian factors, thus providing the possibility to develop new therapeutic approaches. Granulosa cell-derived C-type natriuretic factor not only suppresses the final maturation of oocytes to undergo germinal vesicle breakdown before ovulation but also promotes preantral and antral follicle growth...
February 2015: Endocrine Reviews
https://www.readbyqxmd.com/read/25179603/integrins-regulate-epithelial-cell-differentiation-by-modulating-notch-activity
#16
M Jesús Gómez-Lamarca, Laura Cobreros-Reguera, Beatriz Ibáñez-Jiménez, Isabel M Palacios, María D Martín-Bermudo
Coordinating exit from the cell cycle with differentiation is crucial for proper development and tissue homeostasis. Failure to do so can lead to aberrant organogenesis and tumorigenesis. However, little is known about the developmental signals that regulate the switch from cell cycle exit to differentiation. Signals downstream of two key developmental pathways, Notch and Salvador-Warts-Hippo (SWH), and signals downstream of myosin activity regulate this switch during the development of the follicle cell epithelium of the Drosophila ovary...
November 1, 2014: Journal of Cell Science
https://www.readbyqxmd.com/read/24798736/coupling-of-hedgehog-and-hippo-pathways-promotes-stem-cell-maintenance-by-stimulating-proliferation
#17
Jianhua Huang, Daniel Kalderon
It is essential to define the mechanisms by which external signals regulate adult stem cell numbers, stem cell maintenance, and stem cell proliferation to guide regenerative stem cell therapies and to understand better how cancers originate in stem cells. In this paper, we show that Hedgehog (Hh) signaling in Drosophila melanogaster ovarian follicle stem cells (FSCs) induces the activity of Yorkie (Yki), the transcriptional coactivator of the Hippo pathway, by inducing yki transcription. Moreover, both Hh signaling and Yki positively regulate the rate of FSC proliferation, both are essential for FSC maintenance, and both promote increased FSC longevity and FSC duplication when in excess...
May 12, 2014: Journal of Cell Biology
https://www.readbyqxmd.com/read/24438787/salvador-warts-hippo-signaling-promotes-drosophila-posterior-follicle-cell-maturation-downstream-of-notch
#18
Cédric Polesello, Nicolas Tapon
No abstract text is available yet for this article.
November 20, 2007: Current Biology: CB
https://www.readbyqxmd.com/read/24389730/yap-regulates-cell-proliferation-migration-and-steroidogenesis-in-adult-granulosa-cell-tumors
#19
David Fu, Xiangmin Lv, Guohua Hua, Chunbo He, Jixin Dong, Subodh M Lele, David Wan-Cheng Li, Qiongli Zhai, John S Davis, Cheng Wang
The Hippo signaling pathway has been implicated as a conserved regulator of organ size in both Drosophila and mammals. Yes-associated protein (YAP), the central component of the Hippo signaling cascade, functions as an oncogene in several malignancies. Ovarian granulosa cell tumors (GCT) are characterized by enlargement of the ovary, excess production of estrogen, a high frequency of recurrence, and the potential for malignancy and metastasis. Whether the Hippo pathway plays a role in the pathogenesis of GCT is unknown...
April 2014: Endocrine-related Cancer
https://www.readbyqxmd.com/read/24108406/yap-and-taz-regulate-skin-wound-healing
#20
Min-Jung Lee, Mi Ran Byun, Makoto Furutani-Seiki, Jeong-Ho Hong, Han-Sung Jung
The Hippo signaling pathway regulates organ size, tissue regeneration, and stem cell self-renewal. The two key downstream transcription coactivators in this pathway, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), mediate the major gene regulation and biological functions of the Hippo pathway. The biological functions of YAP and TAZ in many tissues are known; however, their roles in skin wound healing remain unclear. To analyze whether YAP and/or TAZ are required for cutaneous wound healing, we performed small interfering RNA (siRNA)-mediated knockdown of YAP/TAZ in full-thickness skin wounds...
February 2014: Journal of Investigative Dermatology
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