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JOURNAL ARTICLE
Jiazheng Liu, Yafeng Zheng, Limei Lin, Jingyue Guo, Yanan Lv, Jingbin Yuan, Hao Zhai, Xi Chen, Lijun Shen, LinLin Li, Shunong Bai, Hua Han
Germline cells are critical for transmitting genetic information to subsequent generations in biological organisms. While their differentiation from somatic cells during embryonic development is well-documented in most animals, the regulatory mechanisms initiating plant germline cells are not well understood. To thoroughly investigate the complex morphological transformations of their ultrastructure over developmental time, nanoscale 3D reconstruction of entire plant tissues is necessary, achievable exclusively through electron microscopy imaging...
April 2, 2024: Journal of Plant Physiology
#22
JOURNAL ARTICLE
Naomi Kouri, Isabelle Frankenhauser, Zhongwei Peng, Sydney A Labuzan, Baayla D C Boon, Christina M Moloney, Cyril Pottier, Daniel P Wickland, Kelsey Caetano-Anolles, Nick Corriveau-Lecavalier, Jessica F Tranovich, Ashley C Wood, Kelly M Hinkle, Sarah J Lincoln, A J Spychalla, Matthew L Senjem, Scott A Przybelski, Erica Engelberg-Cook, Christopher G Schwarz, Rain S Kwan, Elizabeth R Lesser, Julia E Crook, Rickey E Carter, Owen A Ross, Christian Lachner, Nilüfer Ertekin-Taner, Tanis J Ferman, Julie A Fields, Mary M Machulda, Vijay K Ramanan, Aivi T Nguyen, R Ross Reichard, David T Jones, Jonathan Graff-Radford, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jack, Kejal Kantarci, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Dennis W Dickson, Val J Lowe, Prashanthi Vemuri, Melissa E Murray
IMPORTANCE: Factors associated with clinical heterogeneity in Alzheimer disease (AD) lay along a continuum hypothesized to associate with tangle distribution and are relevant for understanding glial activation considerations in therapeutic advancement. OBJECTIVES: To examine clinicopathologic and neuroimaging characteristics of disease heterogeneity in AD along a quantitative continuum using the corticolimbic index (CLix) to account for individuality of spatially distributed tangles found at autopsy...
April 15, 2024: JAMA Neurology
#23
JOURNAL ARTICLE
Shengjian Fang, Xiaoqing Rui, Yu Zhang, Zhangwei Yang, Weihua Wang
BACKGROUND: Nasal sprays are widely used in treating nasal and sinus diseases; however, there are very few studies on the drug delivery efficiency of nasal sprays. In this study, the drug delivery efficiency of three different nasal spray devices was evaluated in vitro using a 3D printed cast model of nasal cavity. METHODS: Three nasal spray devices with different nozzles and angles of administration were used in the 3D model of the nasal cavity and paranasal sinuses...
2024: PeerJ
#24
JOURNAL ARTICLE
Yu Wang, Guoxun Jing
In order to solve the problem of the blindness of borehole layout when the nonuniform occurrence of gas and the neglect of plastic failure around the borehole will underestimate the gas production, a gas-solid coupling model is established for considering plastic failure. The finite element software COMSOL Multiphysics is used to investigate the evolution of the effective radius during the nonuniform occurrence of gas, and the relationship between the effective radius and the borehole spacing is determined...
April 9, 2024: ACS Omega
#25
JOURNAL ARTICLE
Kaiming Ren, Zhijun Zhang, Haixiang Qin, Jianyu Tan, Xiaowen Hao
The cylindrical regenerative thermal oxidizer (CRTO) came into being later than the three-chamber regenerative thermal oxidizer (TRTO). Compared with TRTO, CRTO has a smaller size and a larger regenerator volume for absorbing and releasing heat. There are few studies on CRTO despite its numerous applications. A CRTO was selected in industrial applications for simulation research. The velocity and temperature of the CRTO were investigated after error analysis of industrial and simulated data. It was found that the velocity and temperature in the regenerative chamber had obvious stratification and gradients after homogenization by the regenerator unit...
April 9, 2024: ACS Omega
#26
Allison L Horenberg, Yunke Ren, Alexandra N Rindone, Arvind P Pathak, Warren L Grayson
Calvarial nerves, along with vasculature, influence skull formation during development and following injury, but it remains unclear how calvarial nerves are spatially distributed during postnatal growth and aging. Studying the spatial distribution of nerves in the skull remains challenging due to a lack of methods to image and quantify 3D structures in intact bone. To visualize calvarial 3D neurovascular architecture, we imaged nerves and endothelial cells with lightsheet microscopy. We employed machine-learning-based segmentation to facilitate high-resolution characterization from post-natal day 0 (P0) to Week 80 (80wk)...
April 1, 2024: bioRxiv
#27
Pooja V Gaikwad, Nazifa Rahman, Pratyusha Ghosh, Dianna Ng, Ryan M Williams
Breast cancer is a substantial source of morbidity and mortality worldwide. It is particularly more difficult to treat at later stages, and treatment regimens depend heavily on both staging and the molecular subtype of the tumor. However, both detection and molecular analyses rely on standard imaging and histological method, which are costly, time-consuming, and lack necessary sensitivity/specificity. The estrogen receptor (ER) is, along with the progesterone receptor (PR) and human epidermal growth factor (HER-2), among the primary molecular markers which inform treatment...
April 1, 2024: bioRxiv
#28
JOURNAL ARTICLE
Tara Gray, Sheen Cherian, Sudha Amarnath, Bingqi Guo, Ping Xia, Allan Wilkinson
High dose rate (HDR) brachytherapy procedures for cervical cancer require multiple applicator insertions for multiple (typically 5) fractions of a single plan, which carries a risk for variability in applicator position between fractions. Due to applicator displacement relative to patient anatomy, the dose to nearby organs-at-risk (OARs) may vary significantly from one fraction to the next. The purpose of this study was to evaluate the effect of changes in HDR tandem and ring (T&R) applicator position on doses to nearby OARs and to present a quick and simple method to estimate doses to OARs inter-fractionally without having to perform a re-plan...
April 13, 2024: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
#29
JOURNAL ARTICLE
Cerium Oxide and Neodymium Oxide Phytoextraction by Ryegrass in Bioenhanced Hydroponic Environments.
Maedeh Soleimanifar, Lucia Rodriguez-Freire
Sustainable technologies for the recovery of rare earth elements (REE) from waste need to be developed to decrease the volume of ore mining extractions and its negative environmental consequences, while simultaneously restoring previously impacted lands. This is critical due to the extensive application of REE in everyday life from electronic devices to energy and medical technologies, and the dispersed distribution of REE resources in the world. REE recovery by plants has been previously studied but the feasibility of REE phytoextraction from a poorly soluble solid phase (i...
April 12, 2024: Environmental Pollution
#30
JOURNAL ARTICLE
Jun Yu, Xian-Pi Zhang, Yi Hao, Ji-Ping Chen, Yuan-Qing Xu
Underwater explosions (UNDEX) generate shock waves that interact with the air-water interface and structures, leading to the occurrence of rarefaction waves and inducing cavitation phenomena. In deep-water explosions, complex coupling relationships exist between shock wave propagation, bubble motion, and cavitation evolution. The shock wave initiates the formation of cavitation, and their growth and collapse are influenced by the pressure field. The collapsing bubbles generate additional shock waves and fluid motion, affecting subsequent shock wave propagation and bubble behavior...
April 13, 2024: Scientific Reports
#31
JOURNAL ARTICLE
Dandan Xu, Handong Liang, Peng Gao
The Wuda coal fire in Inner Mongolia, China, is a global catastrophic event. It emits a huge volume of organic pollutants, including polycyclic aromatic compounds (PACs), which are widely concerning due to their physiological toxicity and environmental persistence. However, there is no systematic study on the enrichment and migration patterns of PACs emitted from coal fires. Here, we compared samples from coal fire sponges and surrounding soil, and analyzed 47 PACs using GC × GC-TOFMS. Data analysis showed that the average content of 16 polycyclic aromatic hydrocarbons (16PAHs) in the coal fire sponge was 15400...
April 13, 2024: Environmental Science and Pollution Research International
#32
JOURNAL ARTICLE
Xiao-Juan Du, Ya-Qian Huang, Xue-Ying Li, Ying Liao, Hong-Fang Jin, Jun-Bao Du
BACKGROUND: Vasovagal syncope (VVS) is the most common type of orthostatic intolerance in children. We investigated whether platelet-related factors related to treatment efficacy in children suffering from VVS treated with metoprolol. METHODS: Metoprolol-treated VVS patients were recruited. The median duration of therapy was three months. Patients were followed and divided into two groups, treament-effective group and treatment-ineffective group. Logistic and least absolute shrinkage selection operator regressions were used to examine treatment outcome variables...
April 13, 2024: World Journal of Pediatrics: WJP
#33
JOURNAL ARTICLE
Lei Wang, Jiaqing Wang, Leilei Wang, Hanghang Dong, Chao Yang, Hao Yan, Yao Xiao, Yong Wang, Shulei Chou, Shuangqiang Chen
A Na4 MnV(PO4 )3 (NMVP) cathode is regarded as a promising cathode candidate for sodium-ion batteries (SIBs). However, issues such as low electronic conductivity and partial cation dissolution contribute to high polarization and structure distortion. Herein, we engineered the local electron density and reaction kinetic properties of NMVP cathodes with varying oxygen vacancies by introducing varying amounts of Zr doping and carbon coating. The optimized sample exhibited a high-rate capacity of 71.8 mAh g-1 at 30 C (83...
April 13, 2024: ACS Nano
#34
JOURNAL ARTICLE
Haoqin Ke, Yu Chen, Baoyi Zhang, Shiwen Duan, Xiaomei Ma, Bingzhong Ren, Yinliang Wang
Insects heavily rely on the olfactory system for food, mating, and predator evasion. However, the caste-related olfactory differences in Apis cerana , a eusocial insect, remain unclear. To explore the peripheral and primary center of the olfactory system link to the caste dimorphism in A. cerana , transcriptome and immunohistochemistry studies on the odorant receptors (ORs) and architecture of antennal lobes (ALs) were performed on different castes. Through transcriptomesis, we found more olfactory receptor genes in queens and workers than in drones, which were further validated by RT-qPCR, indicating caste dimorphism...
April 1, 2024: International Journal of Molecular Sciences
#35
REVIEW
Guangjian Tian, Zhou Wang, Zongwang Huang, Zuyan Xie, Lu Xia, Yi Zhang
Aluminosilicates, such as montmorillonite, kaolinite, halloysite, and diatomite, have a uniform bidimensional structure, a high surface-to-volume ratio, inherent stiffness, a dual charge distribution, chemical inertness, biocompatibility, abundant active groups on the surface, such as silanol (Si-OH) and/or aluminol (Al-OH) groups. These compounds are on the list of U.S. Food and Drug Administration-approved active compounds and excipients and are used for various medicinal products, such as wound healing agents, antidiarrheals, and cosmetics...
April 7, 2024: Materials
#36
JOURNAL ARTICLE
Chuankun Zhou, Fang Cao, Zhirong Yang, Weifeng Rao
The mechanical properties of metastable β-titanium alloys are highly susceptible during the thermal mechanical processing (TMP). In this process, the recrystallization process plays an important role in determining the microstructure and texture evolution. The implementation of dynamic recrystallization (DRX), a process for achieving β-grain refinement, is considered of great significance for the improvement of the properties of metastable β-titanium alloys and their industrial production...
March 29, 2024: Materials
#37
JOURNAL ARTICLE
Erika Chelales, Katriana von Windheim, Arshbir Singh Banipal, Elizabeth Siebeneck, Claire Benham, Corrine A Nief, Brian Crouch, Jeffrey I Everitt, Alan Alper Sag, David F Katz, Nirmala Ramanujam
Ethyl cellulose-ethanol (ECE) is emerging as a promising formulation for ablative injections, with more controllable injection distributions than those from traditional liquid ethanol. This study evaluates the influence of salient injection parameters on forces needed for infusion, depot volume, retention, and shape in a large animal model relevant to human applications. Experiments were conducted to investigate how infusion volume (0.5 mL to 2.5 mL), ECE concentration (6% or 12%), needle gauge (22 G or 27 G), and infusion rate (10 mL/h) impacted the force of infusion into air using a load cell...
April 5, 2024: Polymers
#38
JOURNAL ARTICLE
Francesco Menzione, Matteo Paonni
There is an increasing demand for navigation capability for space vehicles. The exploitation of the so-called Space Service Volume (SSV), and hence the extension of the Global Navigation Satellite System (GNSS) from terrestrial to space users, is currently considered a fundamental step. Knowledge of the constellation antenna pattern, including the side lobe signals, is the main input for assessing the expected GNSS signal availability and navigation performance, especially for high orbits. The best way to define and share this information with the final GNSS user is still an open question...
March 30, 2024: Sensors
#39
JOURNAL ARTICLE
Soorya Pradeep, Thomas A Zangle
The continuous balance of growth and degradation inside cells maintains homeostasis. Disturbance of this balance by internal or external factors cause state of disease, while effective disease treatments seek to restore this balance. Here, we present a method based on quantitative phase imaging (QPI) based measurements of cell mass and the velocity of mass transport to quantify the balance of growth and degradation within intracellular control volumes. The result, which we call Lagrangian velocimetry for intracellular net growth (LVING), provides high resolution maps of intracellular biomass production and degradation...
April 12, 2024: Scientific Reports
#40
JOURNAL ARTICLE
A Rangan, D Balaji, C Saranya, E Raghunathan, N Deepthi, P Karthik
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by inflammation of the synovial joints. Disease activity assessment plays a crucial role in guiding treatment decisions and monitoring disease progression in RA patients. Thus, the current study examines the association between Mean Platelet Volume (MPV), Red Cell Distribution Width (RDW), and disease activity in RA patients. A total of 100 patients were included following the inclusion and exclusion criteria. All participants underwent physical examination and laboratory tests...
February 2024: Georgian Medical News
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