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https://www.readbyqxmd.com/read/29044306/biomarkers-of-renal-recovery-after-acute-kidney-injury
#1
Sérgio Mina Gaião, José Artur Osório de Carvalho Paiva
Novel biomarkers can be suitable for early acute kidney injury diagnosis and the prediction of the need for dialysis. It remains unclear whether such biomarkers may also play a role in the prediction of recovery after established acute kidney injury or in aiding the decision of when to stop renal support therapy. PubMed, Web of Science and Google Scholar were searched for studies that reported on the epidemiology of renal recovery after acute kidney injury, the risk factors of recovery versus non-recovery after acute kidney injury, and potential biomarkers of acute kidney injury recovery...
July 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29042521/-transition-of-children-with-epilepsy-to-adult-care-current-status-and-challenge
#2
Hidemoto Kubota
Thirty percent of the patients consulting a pediatric neurologist have already reached adulthood as patients and their families do not like transfer to the adult clinics; moreover, there are no suitable clinics. Pediatric neurologists find it difficult to examine adult patients with childhood-onset epilepsy as they are unfamiliar with the psychiatric and psychological symptoms manifested in adulthood, and the common diseases of adulthood. On the other hand, adult neurologists have difficulty obtaining a complete picture of the patient's clinical history since childhood, and are unfamiliar with childhood-specific epilepsy syndrome...
October 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29042376/protocol-for-a-cohort-study-of-adolescent-mental-health-service-users-with-a-nested-cluster-randomised-controlled-trial-to-assess-the-clinical-and-cost-effectiveness-of-managed-transition-in-improving-transitions-from-child-to-adult-mental-health-services-the
#3
Swaran P Singh, Helena Tuomainen, Giovanni de Girolamo, Athanasios Maras, Paramala Santosh, Fiona McNicholas, Ulrike Schulze, Diane Purper-Ouakil, Sabine Tremmery, Tomislav Franić, Jason Madan, Moli Paul, Frank C Verhulst, Gwen C Dieleman, Jane Warwick, Dieter Wolke, Cathy Street, Claire Daffern, Priya Tah, James Griffin, Alastair Canaway, Giulia Signorini, Suzanne Gerritsen, Laura Adams, Lesley O'Hara, Sonja Aslan, Frédérick Russet, Nikolina Davidović, Amanda Tuffrey, Anna Wilson, Charlotte Gatherer, Leanne Walker
INTRODUCTION: Disruption of care during transition from child and adolescent mental health services (CAMHS) to adult mental health services may adversely affect the health and well-being of service users. The MILESTONE (Managing the Link and Strengthening Transition from Child to Adult Mental Healthcare) study evaluates the longitudinal course and outcomes of adolescents approaching the transition boundary (TB) of their CAMHS and determines the effectiveness of the model of managed transition in improving outcomes, compared with usual care...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29042060/australian-general-practitioners-initiate-statin-therapy-primarily-on-the-basis-of-lipid-levels-new-zealand-general-practitioners-use-absolute-risk
#4
REVIEW
Chris Schilling, Josh Knight, Duncan Mortimer, Dennis Petrie, Philip Clarke, John Chalmers, Andrew Kerr, Rod Jackson
OBJECTIVES: To compare the determinants of initial statin prescribing between New Zealand and Australia. New Zealand has a system-wide absolute risk-based approach to primary care cardiovascular disease (CVD) management, while Australia has multiple guidelines. METHOD: Classification and Regression Tree (CART) analysis of two observational studies of primary care CVD management from New Zealand (PREDICT-CVD) and Australia (AusHeart). Over 80% of eligible New Zealanders have been screened for CVD risk...
October 10, 2017: Health Policy
https://www.readbyqxmd.com/read/29036474/casanova-a-multiclass-support-vector-machine-model-for-the-classification-of-human-sperm-motility-patterns
#5
Summer G Goodson, Sarah White, Alicia M Stevans, Sanjana Bhat, Chia-Yu Kao, Scott Jaworski, Tamara R Marlowe, Martin Kohlmeier, Leonard McMillan, Steven H Zeisel, Deborah A O'Brien
The ability to accurately monitor alterations in sperm motility is paramount to understanding multiple genetic and biochemical perturbations impacting normal fertilization. Computer-aided sperm analysis (CASA) of human sperm typically reports motile percentage and kinematic parameters at the population level, and uses kinematic gating methods to identify subpopulations such as progressive or hyperactivated sperm. The goal of this study was to develop an automated method that classifies all patterns of human sperm motility during in vitro capacitation following the removal of seminal plasma...
October 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29036444/the-elephant-in-the-room-toward-a-more-ethical-approach-with-accountability-toward-intended-beneficiaries-in-humanitarian-aid
#6
Ramin Asgary, Ronald J Waldman
There is considerable tension between the concept of accountability to beneficiaries and its practice in humanitarian aid. The beneficiaries live in a relationship that is asymmetric; upward or horizontal accountability within the aid system alone-even with the best of intentions-might be short-sighted. Could beneficiaries be effectively involved in programing, priority setting or allocation of resources? Is there space for a rights-based approach in aid delivery and operations? The mind-set, governance and structure of operations in aid agencies may need significant institutional reform to share the process of decision-making, and to transform the current dynamic from connecting resources to brokering better governance, true collaboration and co-operation among all stakeholders...
September 28, 2017: International Health
https://www.readbyqxmd.com/read/29035989/-it-doesn-t-make-sense-for-us-not-to-have-one-understanding-reasons-why-community-sports-organizations-chose-to-participate-in-a-funded-automated-external-defibrillator-program
#7
Lauren V Fortington, Sheree Bekker, Damian Morgan, Caroline F Finch
OBJECTIVE: Implementation of automated external defibrillators (AEDs) in community sports settings is an important component of emergency medical planning. This study aimed to understand motivations for why sports organizations participated in a government-funded program that provided AEDs and associated first-aid training. DESIGN: Face-to-face interviews. SETTING: Community sports organizations in Victoria, Australia. PARTICIPANTS: Representatives from 14 organizations who participated in a government-funded AED program...
October 10, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29034438/the-pathways-fertility-preservation-decision-aid-website-for-women-with-cancer-development-and-field-testing
#8
Terri L Woodard, Aubri S Hoffman, Laura A Covarrubias, Deborah Holman, Leslie Schover, Andrea Bradford, Derek B Hoffman, Aakrati Mathur, Jerah Thomas, Robert J Volk
PURPOSE: To improve survivors' awareness and knowledge of fertility preservation counseling and treatment options, this study engaged survivors and providers to design, develop, and field-test Pathways: a fertility preservation patient decision aid website for young women with cancer©. METHODS: Using an adapted user-centered design process, our stakeholder advisory group and research team designed and optimized the Pathways patient decision aid website through four iterative cycles of review and revision with clinicians (n = 21) and survivors (n = 14)...
October 15, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29034143/decision-aids-to-increase-living-donor-kidney-transplantation
#9
Jennifer C Gander, Elisa J Gordon, Rachel E Patzer
PURPOSE OF REVIEW: For the more than 636,000 adults with end-stage renal disease (ESRD) in the U.S., kidney transplantation is the preferred treatment compared to dialysis. Living donor kidney transplantation (LDKT) comprised 31% of kidney transplantations in 2015, an 8% decrease since 2004. We aimed to summarize the current literature on decision aids that could be used to improve LDKT rates. RECENT FINDINGS: Decision aids are evidence-based tools designed to help patients and their families make difficult treatment decisions...
March 2017: Current Transplantation Reports
https://www.readbyqxmd.com/read/29032883/evaluating-the-accuracy-of-intraoperative-frozen-section-during-inguinal-lymph-node-dissection-in-penile-cancer
#10
Juan Chipollini, Dominic H Tang, Neil Manimala, Scott M Gilbert, Julio M Pow-Sang, Wade J Sexton, Michael A Poch, Philippe E Spiess
INTRODUCTION: Inguinal lymph node dissection is an integral part in the management of invasive penile tumors with intraoperative assessment often aiding decision-making during dissection. In this study, we evaluate the diagnostic value of intraoperative frozen section (FS) and analyze clinicopathologic factors that affect its accuracy. MATERIAL AND METHODS: We, retrospectively, reviewed 84 patients with squamous cell carcinoma of the penis who underwent inguinal lymph node dissection at our institution...
October 9, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29032069/woman-s-pre-conception-evaluation-genetic-and-fetal-risk-considerations-for-counselling-and-informed-choice
#11
REVIEW
R Douglas Wilson
OBJECTIVE: To inform reproductive and other health care providers about genetic and fetal risk information to consider during a woman/couples' pre-conception evaluation, including considerations for genetic risk assessment, genetic screening, or testing to allow for improved counselling and informed choice. OPTIONS: This genetic information can be used for patient education, planning, and possible pre-conception and/or prenatal testing. OUTCOMES: This information may allow improved risk assessment for pre-conception counselling for individual patients and their families...
October 11, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29032050/positive-predictive-value-estimates-for-cell-free-noninvasive-prenatal-screening-from-data-of-a-large-referral-genetic-diagnostic-laboratory
#12
Andrea K Petersen, Sau Wai Cheung, Janice L Smith, Weimin Bi, Patricia A Ward, Sandra Peacock, Alicia Braxton, Ignatia B van den Veyver, Amy M Breman
BACKGROUND: Since its debut in 2011, cell-free fetal DNA (cffDNA) screening has undergone rapid expansion with respect to both utilization and coverage. However, conclusive data regarding the clinical validity and utility of this screening tool, both for the originally included common autosomal and sex-chromosomal aneuploidies as well as the more recently added chromosomal microdeletion syndromes, has lagged behind. Thus, there is a continued need to educate clinicians and patients about the current benefits and limitations of this screening tool to inform pre and post-test counseling, pre/perinatal decision making and medical risk assessment/management...
October 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29031121/facilitating-decision-making-in-women-undergoing-genetic-testing-for-hereditary-breast-cancer-breconda-randomized-controlled-trial-results
#13
Kerry A Sherman, Christopher J Kilby, Laura-Kate Shaw, Caleb Winch, Judy Kirk, Kathy Tucker, Elisabeth Elder
BACKGROUND: Decision-making concerning risk-reducing mastectomy for women at hereditary risk of breast cancer entails complex personal choices. Deciding whether and how to restore breast shape after risk-reducing mastectomy is a key part of this process. We developed a web-based decision aid, BRECONDA (Breast Reconstruction Decision Aid), to assist women in decision-making regarding breast reconstruction. METHOD: This study assessed the efficacy of BRECONDA to assist women at increased risk of breast cancer in making decisions regarding risk-reducing mastectomy in terms of decisional conflict, knowledge, and satisfaction with information...
October 11, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29029753/decision-aid-did-not-reduce-decision-conflict-in-adolescents-considering-receiving-orthodontic-treatment-with-fixed-appliances-at-an-orthodontic-clinic
#14
Romina Brignardello-Petersen
No abstract text is available yet for this article.
October 9, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29026686/pain-prediction-from-ecg-in-vascular-surgery
#15
Tricia Adjei, Wilhelm Von Rosenberg, Valentin Goverdovsky, Katarzyna Powezka, Usman Jaffer, Danilo P Mandic
Varicose vein surgeries are routine outpatient procedures, which are often performed under local anaesthesia. The use of local anaesthesia both minimises the risk to patients and is cost effective, however, a number of patients still experience pain during surgery. Surgical teams must therefore decide to administer either a general or local anaesthetic based on their subjective qualitative assessment of patient anxiety and sensitivity to pain, without any means to objectively validate their decision. To this end, we develop a 3-D polynomial surface fit, of physiological metrics and numerical pain ratings from patients, in order to model the link between the modulation of cardiovascular responses and pain in varicose vein surgeries...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29026458/safe-opioid-prescription-a-smart-on-fhir-approach-to-clinical-decision-support
#16
Shyamashree Sinha, Mark Jensen, Sarah Mullin, Peter L Elkin
Background Prescription opioid pain medication overuse, misuse and abuse have been a significant contributing factor in the opioid epidemic. The rising death rates from opioid overdose have caused healthcare practitioners and researchers to work on optimizing pain therapy and limiting the prescriptions for pain medications. The state of New York has implemented a prescription drug monitoring program(PDMP), amended public health law to limit the prescription of opioids for acute pain and utilized the resources of the state and county health departments to help in curbing this epidemic...
2017: Online Journal of Public Health Informatics
https://www.readbyqxmd.com/read/29025270/design-of-a-randomized-clinical-trial-of-a-colorectal-cancer-screening-decision-aid-to-promote-appropriate-screening-in-community-dwelling-older-adults
#17
Christine E Kistler, Carol Golin, Carolyn Morris, Alexandra F Dalton, Russell P Harris, Rowena Dolor, Renée M Ferrari, Noel T Brewer, Carmen L Lewis
BACKGROUND: Appropriate colorectal cancer screening in older adults should be aligned with the likelihood of net benefit. In general, patient decision aids improve knowledge and values clarity, but in older adults, they may also help patients identify their individual likelihood of benefit and foster individualized decision-making. We report on the design of a randomized clinical trial to understand the effects of a patient decision aid on appropriate colorectal cancer screening. This report includes a description of the baseline characteristics of participants...
August 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29025024/implementing-prescription-drug-monitoring-and-other-clinical-decision-support-for-opioid-risk-mitigation-in-a-military-health-care-setting-a-qualitative-feasibility-study
#18
Erin P Finley, Suyen Schneegans, Claudina Tami, Mary Jo Pugh, Don McGeary, Lauren Penney, Jennifer Sharpe Potter
Objective: Chronic noncancer pain is a highly prevalent condition among service members returning from deployment overseas. The US Army has a higher rate of opioid misuse than the civilian population. Although most states and many health care systems have implemented prescription drug monitoring programs (PDMPs) or other clinician decision support (CDS) to aid providers in delivering guideline-recommended opioid therapy, similar tools are lacking in military health settings. Materials and Methods: We conducted a pre-implementation feasibility and needs assessment guided by the Promoting Action Research in Health Services framework...
August 21, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29024421/generalized-estimating-equation-model-to-compare-drug-effects-on-synovitis-of-the-dominant-wrist-in-severe-rheumatoid-arthritis-between-tocilizumab-versus-adalimumab-versus-abatacept-using-high-resolution-ultrasound
#19
Ying-Chou Chen, Wen-Chan Chiu, Fu-Mei Su, Jia-Feng Chen
PURPOSE: The use of biological agents has revolutionized the treatment of rheumatoid arthritis (RA). However, details of serial synovial changes in imaging evaluation are unclear. Using power Doppler (PD) ultrasound, this study aimed to evaluate the comparative efficacy of biologicals for patients with refractory RA, with the hope that these findings could aid in clinical decision making. METHODS: Patients with RA who received abatacept, adalimumab or tocilizumab therapy were enrolled...
October 12, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29021933/a-survey-based-method-to-evaluate-optimal-treatment-selection-for-escape-maintained-problem-behavior
#20
Valdeep Saini, Alison M Betz, Meagan K Gregory, Yanerys Leon, Nathalie Fernandez
Geiger, Carr, and LeBlanc (2010) developed a decision-making model for escape-maintained problem behavior that could be used to guide the course of treatment selection. We used a digital survey to evaluate the model's potential usefulness. We presented novice and expert practitioners' written hypothetical scenarios and asked them to determine the optimal treatment in a given situation. Some participants were given the model, whereas others were instructed to use their best clinical judgment. Using logistic regression analyses, the general findings for our scenarios were the following: (a) experts without the aid of a decision model had better odds of selecting the optimal treatment than novices without the decision model, (b) experts with the decision model did not have greater odds of selecting optimal treatment than experts without the model, and...
September 2017: Behavior Analysis in Practice
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