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https://www.readbyqxmd.com/read/28449182/validation-of-a-nomogram-for-selecting-patients-for-chemotherapy-after-d2-gastrectomy-for-cancer
#1
Z-X Wang, G-X Li, Z-W Zhou, Z-P Huang, F Wang, R-H Xu
BACKGROUND: According to some guidelines for the management of gastric cancer, adjuvant chemotherapy is recommended for patients with pT3-4 or node-positive disease. The aim of this study was to define low- and high-risk groups in terms of survival, and to predict the benefit of adjuvant fluoropyrimidine plus oxaliplatin (F-OX) chemotherapy. METHODS: Patients with pT3-4 or node-positive gastric cancer after gastrectomy with D2 lymphadenectomy between 2000 and 2013 were included...
April 27, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28449050/cardioscape-mapping-the-cardiovascular-funding-landscape-in-europe
#2
Axel Radlach Pries, Anastasia Naoum, Helmut Habazettl, Mathias Dunkel, Robert Preissner, Caroline J Coats, Ana Tornada, Francesco Orso, Frans Van de Werf, David A Wood
Aims: The burden of cardiovascular disease is increasing worldwide, which has to be reflected by cardiovascular (CV) research in Europe. CardioScape, a FP7 funded project initiated by the European Society of Cardiology (ESC), identified where CV research is performed, how it is funded and by whom. It could be transformed into an on-line and up-to-date resource of great relevance for researchers, funding bodies and policymakers and could be a role model for mapping CV research funding in Europe and beyond...
April 25, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28448386/barriers-to-goal-concordant-care-for-older-patients-with-acute-surgical-illness-communication-patterns-extrinsic-to-decision-aids
#3
Lauren J Taylor, Sara K Johnson, Michael J Nabozny, Jennifer L Tucholka, Nicole M Steffens, Kristine L Kwekkeboom, Karen J Brasel, Toby C Campbell, Margaret L Schwarze
OBJECTIVE: We sought to characterize patterns of communication extrinsic to a decision aid that may impede goal-concordant care. BACKGROUND: Decision aids are designed to facilitate difficult clinical decisions by providing better treatment information. However, these interventions may not be sufficient to effectively reveal patient values and promote preference-aligned decisions for seriously ill, older adults. METHODS: We conducted a secondary analysis of 31 decision-making conversations between surgeons and frail, older inpatients with acute surgical problems at a single tertiary care hospital...
April 26, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28447541/sensor-array-for-detection-of-organic-and-inorganic-contaminants-in-post-consumer-recycled-plastics-for-food-contact
#4
Nathan Davis, Jeffery Danes, Keith Vorst
Post-consumer recycled (PCR) plastic material is made by collecting used plastic products (e.g., bottles and other plastic packaging materials) and re-processing them into solid-state pellets or flakes. Plastic recycling has positive environmental benefits, but may also carry potential drawbacks due to unwanted organic and inorganic contaminants. These contaminants can migrate into food packaging made from these recycled plastic materials. The purpose of this research was to identify economically viable real-time monitoring technologies that can be used during conversion of virgin and recycled resin feedstocks (i...
April 27, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28447000/8th-edition-ajcc-uicc-staging-of-cancers-of-the-esophagus-and-esophagogastric-junction-application-to-clinical-practice
#5
Thomas W Rice, Deepa T Patil, Eugene H Blackstone
The 8th edition of the American Joint Committee on Cancer (AJCC) staging of epithelial cancers of the esophagus and esophagogastric junction (EGJ) presents separate classifications for clinical (cTNM), pathologic (pTNM), and postneoadjuvant (ypTNM) stage groups. Histopathologic cell type markedly affects survival of clinically and pathologically staged patients, requiring separate groupings for each cell type, but ypTNM groupings are identical for both cell types. Clinical categories, typically obtained by imaging with minimal histologic information, are limited by resolution of each method...
March 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28445615/status-epilepticus-in-dogs-and-cats-part-1-etiopathogenesis-epidemiology-and-diagnosis
#6
Susan Blades Golubovic, John H Rossmeisl
OBJECTIVE: To review current knowledge of the etiopathogenesis, diagnosis, and consequences of status epilepticus (SE) in veterinary patients. DATA SOURCES: Human and veterinary literature, including clinical and laboratory research and reviews. ETIOPATHOGENESIS: Status epilepticus is a common emergency in dogs and cats, and may be the first manifestation of a seizure disorder. It results from the failure of termination of an isolated seizure...
April 26, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28445125/intratumoral-heterogeneity-analysis-reveals-hidden-associations-between-protein-expression-losses-and-patient-survival-in-clear-cell-renal-cell-carcinoma
#7
Wei Jiang, Essel Dulaimi, Karthik Devarajan, Theodore Parsons, Qiong Wang, Raymond O'Neill, Charalambos Solomides, Stephen C Peiper, Joseph R Testa, Robert Uzzo, Haifeng Yang
Intratumoral heterogeneity (ITH) is a prominent feature of kidney cancer. It is not known whether it has utility in finding associations between protein expression and clinical parameters. We used ITH that is detected by immunohistochemistry (IHC) to aid the association analysis between the loss of SWI/SNF components and clinical parameters.160 ccRCC tumors (40 per tumor stage) were used to generate tissue microarray (TMA). Four foci from different regions of each tumor were selected. IHC was performed against PBRM1, ARID1A, SETD2, SMARCA4, and SMARCA2...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28444202/application-of-genomic-estimation-methods-of-inbreeding-and-population-structure-in-an-arabian-horse-herd
#8
Mohammed A Al Abri, Uta König von Borstel, Veronique Strecker, Samantha A Brooks
Horse breeders rely heavily on pedigrees for identification of ancestry in breeding stock. Inaccurate pedigrees may erroneously assign individuals to false lineages or breed memberships resulting in wrong estimates of inbreeding and coancestry. Moreover, discrepancies in pedigree records can lead breeders seeking to limit inbreeding into making misguided breeding decisions. Genome-wide SNPs provide a quantitative tool to aid in the resolution of lineage assignments and the calculation of genomic measures of relatedness...
April 21, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28441950/development-of-a-web-based-patient-decision-aid-for-initiating-disease-modifying-anti-rheumatic-drugs-using-user-centred-design-methods
#9
Ingrid Nota, Constance H C Drossaert, Heleen C Melissant, Erik Taal, Harald E Vonkeman, Cees J Haagsma, Mart A F J van de Laar
BACKGROUND: A main element of patient-centred care, Patient Decision Aids (PtDAs) facilitate shared decision-making (SDM). A recent update of the International Patient Decision Aids Standards (IPDAS) emphasised patient involvement during PtDA development, but omitted a methodology for doing so. This article reports on the value of user-centred design (UCD) methods for the development of a PtDA that aims to support inflammatory arthritis patients in their choice between disease modifying anti-rheumatic drugs (DMARDs)...
April 26, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28441481/best-practices-of-computer-aided-drug-discovery-cadd-lessons-learned-from-the-development-of-a-preclinical-candidate-for-prostate-cancer-with-a-new-mechanism-of-action
#10
Fuqiang Ban, Kush Dalal, Huifang Li, Eric LeBlanc, Paul S Rennie, Artem Cherkasov
Small-molecule drug design is a complex and iterative decision-making process relying on pre-existing knowledge and driven by experimental data. Low molecular weight chemicals represent an attractive therapeutic option as they are readily accessible to organic synthesis and can easily be characterized.1 Their potency, as well as pharmacokinetic and pharmacodynamic properties can be systematically and rationally investigated, and ultimately optimized via expert science behind medicinal chemistry and methods of computer-aided drug design (CADD)...
April 25, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28439398/a-practical-approach-to-the-pharmacological-management-of-hypertension-in-older-people
#11
REVIEW
Nikesh Parekh, Amy Page, Khalid Ali, Kevin Davies, Chakravarthi Rajkumar
Hypertension is the leading cause of cardiovascular (CV) morbidity and mortality in adults over the age of 65. The first part of this paper is an overview, summarizing the current guidelines on the pharmacological management of hypertension in older adults in Europe and the USA, and evidence from key trials that contributed to the guidelines. In the second part of the paper, we will discuss the major challenges of managing hypertension in the context of multimorbidity, including frailty, orthostatic hypotension (OH), falls and cognitive impairment that are associated with ageing...
April 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28439169/the-cortical-boundary-line-as-a-guide-for-incisor-re-positioning-with-anterior-segmental-osteotomies
#12
Abraham Vinod Korath, Ratna Padmanabhan, Anantanarayanan Parameswaran
Anterior alveolar anatomical constraints involving presurgical orthodontic incisor repositioning are often unrecognized and overlooked during orthodontic-surgical treatment planning. A clear discrimination of this cortical limitation is invaluable during the planning stage as it permits the consideration of alternative approaches like the anterior maxillary osteotomy for effecting the required incisor movement. A simple reference line termed the "Cortical Boundary Line" is introduced to facilitate the clinical translation of this information and through suitable case illustrations, the construction of the reference line using the conventional lateral cephalometric radiograph and its usefulness as an adjunct in aiding decisions on orthodontic incisor decompensation is highlighted...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28435499/the-fast-and-the-furious-low-risk-chest-pain-and-the-rapid-rule-out-protocol
#13
REVIEW
Maite Anna Huis In 't Veld, Louise Cullen, Simon A Mahler, Barbra E Backus, Zachary D W Dezman, Amal Mattu
Accelerated diagnostic pathways (ADP) have been designed to identify low-risk chest pain patients in the emergency department. This review article discusses the Asia-Pacific Evaluation of Chest Pain Trial (ASPECT) score, the Accelerated Diagnostic Protocol for Chest Pain Trial (ADAPT) score, the Emergency Department Assessment of Chest Pain Score (EDACS), the HEARTScore and the HEART pathway. These ADPs have been validated in various studies and aid the emergency provider with identifying the low-risk chest pain patient who is appropriate for discharge home, while at the same time highlighting those patients who would benefit from further in-patient work up...
April 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28435432/foundation-and-methodologies-in-computer-aided-diagnosis-systems-for-breast-cancer-detection
#14
REVIEW
Afsaneh Jalalian, Syamsiah Mashohor, Rozi Mahmud, Babak Karasfi, M Iqbal B Saripan, Abdul Rahman B Ramli
Breast cancer is the most prevalent cancer that affects women all over the world. Early detection and treatment of breast cancer could decline the mortality rate. Some issues such as technical reasons, which related to imaging quality and human error, increase misdiagnosis of breast cancer by radiologists. Computer-aided detection systems (CADs) are developed to overcome these restrictions and have been studied in many imaging modalities for breast cancer detection in recent years. The CAD systems improve radiologists' performance in finding and discriminating between the normal and abnormal tissues...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28433485/in-hospital-mortality-in-cirrhotic-patients-at-a-tertiary-care-center
#15
R Zubieta-Rodríguez, J Gómez-Correa, R Rodríguez-Amaya, K A Ariza-Mejia, N A Toloza-Cuta
INTRODUCTION: Cirrhosis of the liver is known for its high risk of mortality associated with episodes of acute decompensation. There is an even greater risk in patients that present with acute-on-chronic liver failure. The identification of patients at higher risk for adverse outcomes can aid in making the clinical decisions that will improve the prognosis for these patients. AIMS: To determine in-hospital mortality and evaluate the epidemiologic and clinical characteristics of patients with cirrhosis of the liver seen at a tertiary referral hospital...
April 19, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28429679/mycobacterium-avium-complex-disease
#16
Charles L Daley
Despite the ubiqitous nature of Mycobacterium avium complex (MAC) organisms in the environment, relatively few of those who are infected develop disease. Thus, some degree of susceptibility due to either underlying lung disease or immunosuppression is required. The frequency of pulmonary MAC disease is increasing in many areas, and the exact reasons are unknown. Isolation of MAC from a respiratory specimen does not necessarily mean that treatment is required, as the decision to treatment requires the synthesis of clinical, radiographic, and microbiologic information as well as a weighing of the risks and benefits for the individual patient...
April 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28429239/development-and-initial-validation-of-a-short-three-dimensional-inventory-of-character-strengths
#17
Wenjie Duan, He Bu
PURPOSE: Character strength is described as a positive and organized pattern of emotions, thoughts, and behaviors. It serves as a schema that organizes categories of information toward the self, others, and the world, and provides the self-aware knowledge that facilitates the pursuit of goals, values, and ethical principles. Recent research has suggested that three reliable factors emerge from the measures of character strengths: caring, inquisitiveness, and self-control. The goal of this paper is to develop a psychometrically sound short measure of character strength...
April 20, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28424454/inference-of-the-infection-status-of-individuals-using-longitudinal-testing-data-from-cryptic-populations-towards-a-probabilistic-approach-to-diagnosis
#18
Svetlana N Buzdugan, Timothée Vergne, Vladimir Grosbois, Richard J Delahay, Julian A Drewe
Effective control of many diseases requires the accurate detection of infected individuals. Confidently ascertaining whether an individual is infected can be challenging when diagnostic tests are imperfect and when some individuals go for long periods of time without being observed or sampled. Here, we use a multi-event capture-recapture approach to model imperfect observations of true epidemiological states. We describe a method for interpreting potentially disparate results from individuals sampled multiple times over an extended period, using empirical data from a wild badger population naturally infected with Mycobacterium bovis as an example...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28423165/a-randomized-comparison-between-league-tables-and-funnel-plots-to-inform-health-care-decision-making
#19
Anders Anell, Oskar Hagberg, Fredrik Liedberg, Stefan Ryden
Objective: Comparison of provider performance is commonly used to inform health care decision-making. Little attention has been paid to how data presentations influence decisions. This study analyzes differences in suggested actions by decision-makers informed by league tables or funnel plots. Design: Decision-makers were invited to a survey and randomized to compare hospital performance using either league tables or funnel plots for four different measures within the area of cancer care...
December 1, 2016: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28422672/aiimds-an-integrated-framework-of-automatic-idiopathic-inflammatory-myopathy-diagnosis-for-muscle
#20
Manish Sapkota, Fujun Liu, Yuanpu Xie, Hai Su, Fuyong Xing, Lin Yang
Idiopathic Inflammatory Myopathy (IIM) is a common skeletal muscle disease that relates to weakness and inflammation of muscle. Early diagnosis and prognosis of different types of IIMs will guide the effective treatment. Interpretation of digitized images of the cross section muscle biopsy, which is currently done manually, provides the most reliable diagnostic information. With the increasing volume of images, the management and manual interpretation of the digitized muscle images suffer from low efficiency and high interobserver variabilities...
April 13, 2017: IEEE Journal of Biomedical and Health Informatics
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