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https://www.readbyqxmd.com/read/29238335/treatment-with-cefotaxime-affects-expression-of-conjugation-associated-proteins-and-conjugation-transfer-frequency-of-an-inci1-plasmid-in-escherichia-coli
#1
Thea S B Møller, Gang Liu, Anders Boysen, Line E Thomsen, Freja L Lüthje, Sisse Mortensen, Jakob Møller-Jensen, John E Olsen
Horizontal gene transfer (HGT) is the major mechanism responsible for spread of antibiotic resistance. Antibiotic treatment has been suggested to promote HGT, either by directly affecting the conjugation process itself or by selecting for conjugations subsequent to DNA transfer. However, recent research suggests that the effect of antibiotic treatment on plasmid conjugation frequencies, and hence the spread of resistance plasmids, may have been overestimated. We addressed the question by quantifying transfer proteins and conjugation frequencies of a blaCTX-M-1 encoding IncI1 resistance plasmid in Escherichia coli MG1655 in the presence and absence of therapeutically relevant concentrations of cefotaxime (CTX)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29237185/-how-are-effects-of-patient-education-programs-influenced-by-psychosocial-risk-factors-in-pediatrics
#2
Ingo Menrath, Gundula Ernst, Kirsten Mönkemöller, Christine Lehmann, Angela Eberding, Esther Müller-Godeffroy, Rüdiger Szczepanski, Karin Lange, Doris Staab, Ute Thyen
Background Modular patient education programs are effective in children with chronic conditions and their families. Little is known about the influence of socioeconomic status (SES), migration background (MB) and children's mental-health problems on the programs' effects. Objectives Do SES, MB or mental-health problems influence the success of education programs (disease-specific knowledge, children's health-related quality of life (HRQoL) and life satisfaction and parents' condition-specific burden)? Materials and methods Children with different chronic conditions and their parents participated in modular patient education programs...
December 13, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29236392/effect-of-preparations-methyure-and-ivine-on-%C3%B0-%C3%B0-2-atpases-activity-in-plasma-and-vacuolar-membrane-of-corn-seedling-roots-under-salt-stress-conditions
#3
M V Rudnytska, T A Palladina
Ca2+-ATPases regulate the functioning of Ca2+-dependent signaling pathway SOS which provides removal of Na+ from the cytoplasm of cells via Na+/H+-antiporters in saline conditions. The influence of synthetic preparations Methyure and Ivine on the Ca2+-ATPase activity was investigated. It was shown that exposition of corn seedlings in the presence of 0.1 M NaCl rather enhanced hydrolytic than transport activity of Ca2+-ATPases in plasma and vacuolar membrane of root cells. It was found that seed treatment with such preparations, especially Methyure, caused intensification of the both activities of Ca2+-ATPases, mainly in vacuolar membrane...
January 2017: Ukrainian Biochemical Journal
https://www.readbyqxmd.com/read/29235861/kras-switch-mutants-d33e-and-a59g-crystallize-in-the-state-1-conformation
#4
Jia Lu, Asim Bera, Sudershan R Gondi, Kenneth Dale Westover
KRAS switch loop movements play a crucial role in regulating RAS signaling and alteration in these sensitive dynamics are a principal mechanism through which disease-associated RAS mutations lead to aberrant RAS activation. Prior studies suggest that despite high sequence similarity, the switches in KRAS are more dynamic than HRAS. We solved x-ray crystal structures of the rare tumorigenic KRAS mutants KRASD33E, in switch 1 (SW1), and KRASA59G, in switch 2 (SW2), bound to GDP and found these adopt nearly identical, open SW1 conformations as well as altered SW2 conformations...
December 13, 2017: Biochemistry
https://www.readbyqxmd.com/read/29234315/food-associated-lactobacillus-plantarum-and-yeasts-inhibit-the-genotoxic-effect-of-4-nitroquinoline-1-oxide
#5
Roberta Prete, Rosanna Tofalo, Ermanno Federici, Aurora Ciarrocchi, Giovanni Cenci, Aldo Corsetti
Lactic acid bacteria and yeasts, representing the prevailing microbiota associated with different foods generally consumed without any cooking, were identified and characterized in vitro for some functional properties, such as acid-bile tolerance and antigenotoxic activity. In particular, 22 Lactobacillus plantarum strains and 14 yeasts were studied. The gastro-intestinal tract tolerance of all the strains was determined by exposing washed cell suspensions at 37°C to a simulated gastric juice (pH 2.0), containing pepsin (0...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29233778/phenotypic-indications-of-ftsz-inhibition-in-hok-sok-induced-bacterial-growth-changes-and-stress-response
#6
ChinweU Chukwudi, Liam Good
The hok/sok locus has been shown to enhance the growth of bacteria in adverse growth conditions such as high temperature, low starting-culture densities and antibiotic treatment. This is in addition to their well-established plasmid-stabilization effect via post-segregational killing of plasmid-free daughter cells. It delays the onset of growth by prolonging the lag phase of bacterial culture, and increases the rate of exponential growth when growth eventually begins. This enables the cells adapt to the prevailing growth conditions and enhance their survival in stressful conditions...
December 9, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29232146/switchable-photoacoustic-intensity-of-methylene-blue-via-sodium-dodecyl-sulfate-micellization
#7
Junxin Wang, Ching-Yu Lin, Colman Moore, Anamik Jhunjhunwala, Jesse V Jokerst
The interaction between methylene blue (MB) and sodium dodecyl sulfate (SDS) has been widely studied spectroscopically, but details about their interactions are limited. Here, we combined photoacoustic (PA) imaging with nanoparticle tracking analysis (NTA) and spectroscopy to further elucidate this interaction. PA imaging of 0.05 mM MB showed a 492-fold increase in intensity upon addition of 3.47 mM SDS. Higher concentrations above SDS's critical micelle concentration (CMC) at 8.67 mM decreased the PA intensity by 54-fold...
December 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29232026/noncontrast-enhanced-time-resolved-4d-dynamic-intracranial-mr-angiography-at-7t-a-feasibility-study
#8
Fei Cong, Yan Zhuo, Songlin Yu, Xianchang Zhang, Xinyuan Miao, Jing An, Shuo Wang, Yong Cao, Yan Zhang, Hee Kwon Song, Danny Jj Wang, Lirong Yan
BACKGROUND: Arterial spin labeling (ASL) based-noncontrast-enhanced 4D MR angiography (NCE 4D MRA) shows potential in characterizing cerebrovascular hemodynamics in cerebrovascular disorders. Ultrahigh-field theoretically benefits ASL signal with increased inherent signal-to-noise ratio (SNR) and prolonged blood T1 , which may provide improved delineation of vasculature in 4D MRA. PURPOSE: To investigate the feasibility of NCE 4D MRA using 3D Cartesian trajectory and stack-of-stars (SOS) golden angle radial trajectory at 7T...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29227469/integrative-single-cell-analysis-of-transcriptional-and-epigenetic-states-in-the-human-adult-brain
#9
Blue B Lake, Song Chen, Brandon C Sos, Jean Fan, Gwendolyn E Kaeser, Yun C Yung, Thu E Duong, Derek Gao, Jerold Chun, Peter V Kharchenko, Kun Zhang
Detailed characterization of the cell types in the human brain requires scalable experimental approaches to examine multiple aspects of the molecular state of individual cells, as well as computational integration of the data to produce unified cell-state annotations. Here we report improved high-throughput methods for single-nucleus droplet-based sequencing (snDrop-seq) and single-cell transposome hypersensitive site sequencing (scTHS-seq). We used each method to acquire nuclear transcriptomic and DNA accessibility maps for >60,000 single cells from human adult visual cortex, frontal cortex, and cerebellum...
December 11, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/29221461/seeking-a-second-medical-opinion-composition-reasons-and-perceived-outcomes-in-israel
#10
Liora Shmueli, Nadav Davidovitch, Joseph S Pliskin, Ran D Balicer, Igal Hekselman, Geva Greenfield
BACKGROUND: Seeking a second-opinion (SO) is a common clinical practice that can optimize treatment and reduce unnecessary procedures and risks. We aim to characterize the composition of the population of SO seekers, their reasons for seeking a SO and choosing a specific physician, and their perceived outcomes following the SO. METHODS: A cross-sectional national telephone survey, using a representative sample of the general Israeli population (n = 848, response rate = 62%)...
December 8, 2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29218616/noninvasive-assessment-of-hepatic-sinusoidal-obstructive-syndrome-using-acoustic-radiation-force-impulse-elastography-imaging-a-proof-of-concept-study-in-rat-models
#11
So Hyun Park, Seung Soo Lee, Ji-Youn Sung, Kiyong Na, Hyoung Jung Kim, So Yeon Kim, Beom Jin Park, Jae Ho Byun
OBJECTIVES: To determine the feasibility of acoustic radiation force impulse (ARFI) elastography in the evaluation of hepatic sinusoidal obstruction syndrome (SOS) in rat models. METHODS: Rat SOS models of various severities were created by monocrotaline gavage (n = 40) or by intraperitoneal injection of 5-fluorouracil, leucovorin and oxaliplatin (FOLFOX) (n = 16). Liver shear-wave velocity (SWV) was measured using ARFI elastography. Liver samples were analysed for the SOS score, steatosis, lobular inflammation and fibrosis...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29218042/corrigendum-gene-expression-in-class-2-integrons-is-sos-independent-and-involves-two-pc-promoters
#12
Thomas Jové, Sandra Da Re, Aurore Tabesse, Amy Gassama-Sow, Marie-Cécile Ploy
[This corrects the article on p. 1499 in vol. 8, PMID: 28861047.].
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29215045/auditory-closed-loop-stimulation-of-eeg-slow-oscillations-strengthens-sleep-and-signs-of-its-immune-supportive-function
#13
Luciana Besedovsky, Hong-Viet V Ngo, Stoyan Dimitrov, Christoph Gassenmaier, Rainer Lehmann, Jan Born
Sleep is essential for health. Slow wave sleep (SWS), the deepest sleep stage hallmarked by electroencephalographic slow oscillations (SOs), appears of particular relevance here. SWS is associated with a unique endocrine milieu comprising minimum cortisol and high aldosterone, growth hormone (GH), and prolactin levels, thereby presumably fostering efficient adaptive immune responses. Yet, whether SWS causes these changes is unclear. Here we enhance SOs in men by auditory closed-loop stimulation, i.e., by delivering tones in synchrony with endogenous SOs...
December 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29207299/a-novel-screening-method-to-identify-air-pollution-by-genotoxic-compounds
#14
Daniela Baráková, Anežka Sharma, Mária Chropeňová, Pavel Čupr
Genotoxic compounds, as common contaminants of the air environment, are of interest in air pollution monitoring. There are several methods to determine the level of these contaminants in different localities, many of which may be difficult to access with the use of conventional active and passive samplers. In the present study, the needles Pinus mugo Turra and Picea abies were used to monitor sampling localities in Austria, Slovakia, and the Czech Republic. Needles were extracted and chemical analysis and the genotoxicity bioassay SOS chromotest were used to obtain complex information about the chemical mixture of pollutants present and their genotoxic effects...
December 2, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29199771/cling-film-as-storage-medium-for-avulsed-teeth-an-in-vitro-pilot-study
#15
Anja Zeissler-Lajtman, Thomas Connert, Sebastian Kühl, Andreas Filippi
The long-term prognosis of avulsed teeth primarily depends on the behavior at the scene of the accident. Lay people are not able to perform an immediate replantation. Therefore, particular significance belongs to the cellphysiologic storage of avulsed teeth. The aim of this pilot study was to evaluate whether cling film facilitates the survival of periodontal ligament cells in vitro. For this purpose, healthy human third molars were used. They were cut into root slices, which were stored in one of five test media: SOS Zahnbox ® , UHT milk (4 °C), sterile isotonic saline solution, tap water, and cling film...
2017: Swiss Dental Journal
https://www.readbyqxmd.com/read/29197646/one-stage-and-two-stage-meta-analysis-of-individual-participant-data-led-to-consistent-summarized-evidence-lessons-learned-from-combining-multiple-databases
#16
Lorenza Scotti, Federico Rea, Giovanni Corrao
OBJECTIVE: Combining multiple healthcare databases allows comparing the effects of a wide variety of healthcare services. There is a growing interest in methods for combining the results from multiple databases. We attempted to learn lessons about the performance of one-stage and two-stage approaches from the re-analysis of data drawn from two studies of pharmacoepidemiology based on multiple databases. STUDY DESIGN AND SETTING: Two nested case-control studies were carried out for estimating the tricyclic antidepressants-arrhythmia and etoricoxib-heart failure associations, respectively from the Italian I-GrADE and the European SOS programs...
November 29, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29196074/acute-kidney-injury-in-pediatric-patients-receiving-allogeneic-hematopoietic-cell-transplantation-incidence-risk-factors-and-outcomes
#17
Kyung-Nam Koh, Anusha Sunkara, Guolian Kang, Amanda Sooter, Daniel A Mulrooney, Brandon Triplett, Ali Mirza Onder, John Bissler, Lea C Cunningham
Acute kidney injury (AKI) is a common adverse event following hematopoietic cell transplantation (HCT). AKI is associated with early death or chronic kidney disease among transplant survivors. However, large-scale pediatric studies based on standardized criteria are lacking. We performed a retrospective analysis of 1057 pediatric patients who received allogeneic HCT to evaluate the incidence and risk factors of AKI according to AKI Network criteria within the first 100 days of HCT. We also determined the effect of AKI on patient survival...
November 28, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29193518/antimicrobial-activity-of-the-indolicidin-derived-novel-synthetic-peptide-in-58
#18
A S Vasilchenko, A V Vasilchenko, T M Pashkova, M P Smirnova, N I Kolodkin, I V Manukhov, G B Zavilgelsky, E A Sizova, O L Kartashova, A S Simbirtsev, E A Rogozhin, G K Duskaev, M V Sycheva
Natural peptides with antimicrobial activity are extremely diverse, and peptide synthesis technologies make it possible to significantly improve their properties for specific tasks. Here, we investigate the biological properties of the natural peptide indolicidin and the indolicidin-derived novel synthetic peptide In-58. In-58 was generated by replacing all tryptophan residues on phenylalanine in D-configuration; the α-amino group in the main chain also was modified by unsaturated fatty acid. Compared with indolicidin, In-58 is more bactericidal, more resistant to proteinase K, and less toxic to mammalian cells...
December 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29192510/aflatoxin-b1-detoxification-by-cell-free%C3%A2-extracts-of-rhodococcus-strains
#19
Anita Risa, Dalma Maja Divinyi, Erzsébet Baka, Csilla Krifaton
Aflatoxin B1 (AFB1) produced by Aspergillus molds is a genotoxic and carcinogenic mycotoxin. For the elimination of mycotoxins from food and feed, biodetoxification can be a successful tool. The aim of this study was to reveal biodetoxification with the cell-free extracts of Rhodococcus erythropolis NI1 and Rhodococcus rhodochrous NI2, which have been already proved to detoxify AFB1. Extracellular matrices of cultures and also intracellular extracts were applied for detoxification. In both cases, media containing constitutively produced and AFB1-induced enzymes were tested, respectively...
December 1, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/29186638/stent-over-sponge-sos-a-novel-technique-complementing-endosponge-therapy-for-foregut-leaks-and-perforations
#20
Piero V Valli, Joachim C Mertens, Arne Kröger, Christoph Gubler, Christian Gutschow, Paul M Schneider, Peter Bauerfeind
Background and study aims Endoluminal vacuum therapy (EVT) has evolved as a promising option for endoscopic treatment of foregut wall injuries in addition to the classic closure techniques using clips or stents. To improve vacuum force and maintain esophageal passage, we combined endosponge treatment with a partially covered self-expandable metal stent (stent-over-sponge; SOS). Patients and methods Twelve patients with infected upper gastrointestinal wall defects were treated with the SOS technique. Results Indications for SOS were anastomotic leakage after surgery (n = 11) and chronic foregut fistula (n = 1)...
October 27, 2017: Endoscopy
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