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https://www.readbyqxmd.com/read/27912095/the-ras-mapk-axis-gets-stressed-out
#1
Scott A Foster, Shiva Malek
In this issue of Molecular Cell, Ritt et al. (2016) describe a stress-induced checkpoint that effectively suppresses RAS-MAPK signaling. This pathway, activated by agents such as Rigosertib that induce mitotic and oxidative stress, results in JNK-mediated inhibition of RAS-MAPK pathway components SOS and RAF.
December 1, 2016: Molecular Cell
https://www.readbyqxmd.com/read/27910584/fitting-of-the-thomson-scattering-density-and-temperature-profiles-on-the-compass-tokamak
#2
E Stefanikova, M Peterka, P Bohm, P Bilkova, M Aftanas, M Sos, J Urban, M Hron, R Panek
A new technique for fitting the full radial profiles of electron density and temperature obtained by the Thomson scattering diagnostic in H-mode discharges on the COMPASS tokamak is described. The technique combines the conventionally used modified hyperbolic tangent function for the edge transport barrier (pedestal) fitting and a modification of a Gaussian function for fitting the core plasma. Low number of parameters of this combined function and their straightforward interpretability and controllability provide a robust method for obtaining physically reasonable profile fits...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910390/validation-of-fast-ion-d-alpha-spectrum-measurements-during-east-neutral-beam-heated-plasmas
#3
J Huang, W W Heidbrink, M G von Hellermann, L Stagner, C R Wu, Y M Hou, J F Chang, S Y Ding, Y J Chen, Y B Zhu, Z Jin, Z Xu, W Gao, J F Wang, B Lyu, Q Zang, G Q Zhong, L Hu, B Wan
To investigate the fast ion behavior, a fast ion D-alpha (FIDA) diagnostic system has been installed on EAST. Fast ion features can be inferred from the Doppler shifted spectrum of Balmer-alpha light from energetic hydrogenic atoms. This paper will focus on the validation of FIDA measurements performed using MHD-quiescent discharges in 2015 campaign. Two codes have been applied to calculate the Dα spectrum: one is a Monte Carlo code, Fortran 90 version FIDASIM, and the other is an analytical code, Simulation of Spectra (SOS)...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27901060/body-composition-and-bone-mineral-status-in-patients-with-turner-syndrome
#4
Kun Shi, Li Liu, Yao-Juan He, Duan Li, Lian-Xiong Yuan, Gendie E Lash, Li Li
Turner syndrome (TS) is associated with decreased bone mineral density and increased fracture rate. However, the developmental trajectory of bone density or body composition in patients with TS is still unclear. The present study tested the hypothesis that different karyotypes and/or age contributes to abnormal body composition and decreased bone mineral status parameters in patients with TS. This study included 24 girls with TS, in which 13 girls exhibited X0 karyotype and 11 had mosaicism. Quantitative ultrasound (QUS) assessed the bone mineral status of the calcaneus, including bone mineral density (BMD), amplitude-dependent speed of sound (AD-SOS), broadband ultrasound attenuation (BUA) and InBody 770 assessed body composition...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27899755/association-of-oxidized-low-density-lipoprotein-with-prognosis-of-stroke-and-stroke-subtypes
#5
Anxin Wang, Yuling Yang, Zhaoping Su, Wei Yue, Hongjun Hao, Lijie Ren, Yongjun Wang, Yibin Cao, Yilong Wang
BACKGROUND AND PURPOSE: The association between oxidized low-density lipoprotein (oxLDL) and the long-term prognosis of stroke is unclear. The aim of this study is to investigate whether oxLDL levels contribute to the prognosis of stroke and stroke subtypes. METHODS: All patients with ischemic stroke were recruited from the SOS-Stroke (Study of Oxidative Stress in Patients With Acute Ischemic Stroke) and classified into 5 different subtypes, according to the TOAST criteria (Trial of Org 10172 in Acute Stroke Treatment)...
November 29, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27892944/veno-occlusive-disease-sinusoidal-obstruction-syndrome-after-haematopoietic-stem-cell-transplantation-middle-east-north-africa-regional-consensus-on-prevention-diagnosis-and-management
#6
A H Al Jefri, H Abujazar, A Al-Ahmari, A Al Rawas, Z Al Zahrani, A Alhejazi, M A Bekadja, A Ibrahim, M Lahoucine, S Ousia, A Bazarbachi
Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) of the liver is a serious, early complication of haematopoietic stem cell transplantation (HSCT), severe and very severe forms of which are associated with a high mortality rate. A wide variety of patient, disease and treatment-related risk factors for VOD/SOS have been identified. Several bodies have published recommendations for the diagnosis, prevention and management of VOD/SOS following HSCT. A group of regional experts have developed a consensus statement on the diagnosis, prevention and management of VOD/SOS in the Middle East and North Africa region to help in the management of HSCT patients in the region...
November 28, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27889231/nimbolide-inhibits-androgen-independent-prostate-cancer-cells-survival-and-proliferation-by-modulating-multiple-pro-survival-signaling-pathways
#7
P Raja Singh, E Sugantha Priya, S Balakrishnan, R Arunkumar, G Sharmila, M Rajalakshmi, J Arunakaran
BACKGROUND: Prostate cancer is the most prominent cancer in men, experiencing a relapse in disease often express high serum TNF-α levels. It has been correlated with increased cell survival and proliferation of prostate cancer cells. Previous studies reported that nimbolide, a terpenoid derived from the leaves and flowers of neem tree inhibits cancer growth through selective modulation of cell signaling pathways linked to inflammation, survival, proliferation, angiogenesis and metastasis...
November 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27887814/effect-of-bromide-on-the-transformation-and-genotoxicity-of-octyl-dimethyl-p-aminobenzoic-acid-during-chlorination
#8
Qiwan Chai, Shujuan Zhang, Xiaomao Wang, Hongwei Yang, Yuefeng F Xie
Octyl-dimethyl-p-aminobenzoic acid (ODPABA), one of the most commonly used organic UV filters, can undergo considerable transformation in water when entering into the disinfection process. The impacts of bromide on degradation kinetics, formation and speciation of transformation products, regulated disinfection by-products (DBPs) as well as genotoxicity changes during ODPABA chlorination were investigated in this study. Results indicated that the reaction of ODPABA with chlorine followed pseudo-first-order and second-order kinetics...
November 15, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27885340/acute-kidney-injury-in-hematopoietic-stem-cell-transplantation-a-review
#9
REVIEW
Vinod Krishnappa, Mohit Gupta, Gurusidda Manu, Shivani Kwatra, Osei-Tutu Owusu, Rupesh Raina
Hematopoietic stem cell transplantation (HSCT) is a highly effective treatment strategy for lymphoproliferative disorders and bone marrow failure states including aplastic anemia and thalassemia. However, its use has been limited by the increased treatment related complications, including acute kidney injury (AKI) with an incidence ranging from 20% to 73%. AKI after HSCT has been associated with an increased risk of mortality. The incidence of AKI reported in recipients of myeloablative allogeneic transplant is considerably higher in comparison to other subclasses mainly due to use of cyclosporine and development of graft-versus-host disease (GVHD) in allogeneic groups...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27881980/comparative-genomics-of-dna-recombination-and-repair-in-cyanobacteria-biotechnological-implications
#10
REVIEW
Corinne Cassier-Chauvat, Théo Veaudor, Franck Chauvat
Cyanobacteria are fascinating photosynthetic prokaryotes that are regarded as the ancestors of the plant chloroplast; the purveyors of oxygen and biomass for the food chain; and promising cell factories for an environmentally friendly production of chemicals. In colonizing most waters and soils of our planet, cyanobacteria are inevitably challenged by environmental stresses that generate DNA damages. Furthermore, many strains engineered for biotechnological purposes can use DNA recombination to stop synthesizing the biotechnological product...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27881042/correlation-between-spheno-occipital-synchondrosis-dental-age-chronological-age-and-cervical-vertebrae-maturation-in-turkish-population-is-there-a-link
#11
Husniye Demirturk Kocasarac, Ayse Burcu Altan, Canan Yerlikaya, Alper Sinanoglu, Marcel Noujeim
OBJECTIVE: To assess the correlation between third molar mineralization (TMM), spheno-occipital synchondrosis (SOS) fusion, chronologic age and cervical vertebrae maturation (CVM) for skeletal maturation. MATERIALS AND METHODS: Radiographs for 116 patients between 8 and 28 years were evaluated for age determination using mandibular TMM, SOS fusion and CVM. Spearman Correlation and Kappa test analyses were used to assess the relationship between variables and for intraobserver reliability...
November 24, 2016: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/27874117/quantitative-analyses-of-enhanced-thermoelectric-properties-of-modulation-doped-pedot-pss-undoped-si-001-nanoscale-heterostructures
#12
Dongwook Lee, Sayed Youssef Sayed, Sangyeop Lee, Chris Adam Kuryak, Jiawei Zhou, Gang Chen, Yang Shao-Horn
Poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS) has high electrical conductivity (∼10(3) S cm(-1)) but it exhibits a low Seebeck coefficient (<15 μV K(-1)), resulting in a low power factor. Mixing PEDOT:PSS with nanostructured semiconductors can enhance the Seebeck coefficient and achieve an improved thermoelectric power factor. However, underlying mechanisms for those composite thermoelectric systems are scarcely understood so far. In this study, quantitative analyses on the electrical conductivity and Seebeck coefficient for the heterostructures of nanometer-thick PEDOT:PSS on single-crystal Si (001) on sapphire (SOS) are reported...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27867652/is-it-possible-to-terminate-resuscitation-in-accordance-with-the-termination-of-resuscitation-rule
#13
COMMENT
Masahiro Kashiura
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27866692/does-the-number-of-emergency-medical-technicians-affect-the-neurological-outcome-of-patients-with-out-of-hospital-cardiac-arrest
#14
Shuichi Hagiwara, Kiyohiro Oshima, Makoto Aoki, Dai Miyazaki, Atsushi Sakurai, Yoshio Tahara, Ken Nagao, Naohiro Yonemoto, Arino Yaguchi, Naoto Morimura
BACKGROUND: It is unclear whether the number of paramedics in an ambulance improves the outcome of patients with out-of-hospital cardiac arrest (OHCA) or not. METHODS AND RESULTS: This study was a prospective, observational study conducted on patients with OHCA. Patients were divided into the One-paramedic group (Group O) and the Two-or-more-paramedic group (Group T) and we analyzed the differences. Patients who were treated with only basic life support during transportation, and whose cause of cardiac arrest were extrinsic cause such as trauma and poisoning were excluded...
November 10, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27852598/frailty-and-bone-health-in-european-men
#15
Michael J Cook, Alexander Oldroyd, Stephen R Pye, Kate A Ward, Evelien Gielen, Rathi Ravindrarajah, Judith E Adams, David M Lee, Gyorgy Bartfai, Steven Boonen, Felipe Casanueva, Gianni Forti, Aleksander Giwercman, Thang S Han, Ilpo T Huhtaniemi, Krzysztof Kula, Michael E Lean, Neil Pendleton, Margus Punab, Dirk Vanderschueren, Frederick C Wu, Terence W O'Neill
BACKGROUND: frailty is associated with an increased risk of fragility fractures. Less is known, however, about the association between frailty and bone health. METHODS: men aged 40-79 years were recruited from population registers in eight European centres for participation in the European Male Aging Study. Subjects completed a comprehensive assessment which included quantitative ultrasound (QUS) scan of the heel (Hologic-SAHARA) and in two centres, dual-energy bone densitometry (dual-energy x-ray absorptiometry, DXA)...
November 16, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27843363/defibrotide-in-the-treatment-of-hepatic-veno-occlusive-disease
#16
REVIEW
Alessandro Fulgenzi, Maria Elena Ferrero
Hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), represents the most frequent complication in patients in early phase following hematopoietic stem-cell transplantation (HSCT). In its severe form, VOD/SOS can be associated with multiorgan failure and with a mortality rate >80% by day +100. Defibrotide (DF) (a mixture of 90% single-stranded phosphodiester oligonucleotides and 10% double-stranded phosphodiester oligonucleotides derived from controlled depolarization of porcine intestinal mucosal DNA) has been proposed for the treatment of SOS due to its ability to restore thrombo-fibrinolytic balance and protect endothelial cells...
2016: Hepatic Medicine: Evidence and Research
https://www.readbyqxmd.com/read/27833455/a-decision-support-system-dss-for-municipal-nurses-encountering-health-deterioration-among-older-people
#17
Annica Kihlgren, Fredrik Svensson, Conny Lövbrand, Mervyn Gifford, Annsofie Adolfsson
BACKGROUND: This study is part of a larger project called ViSam and includes testing of a decision support system developed and adapted for older people on the basis of M (R) ETTS (Rapid Emergency Triage and Treatment System). The system is designed to allow municipal nurses to determine the optimal level of care for older people whose health has deteriorated. This new system will allow more structured assessment, the patient should receive optimal care and improved data transmission to the next caregiver...
2016: BMC Nursing
https://www.readbyqxmd.com/read/27833027/bufalin-inhibits-gefitinib-resistant-nci-h460-human-lung-cancer-cell-migration-and-invasion-in-vitro
#18
An-Cheng Huang, Mei-Due Yang, Yung-Ting Hsiao, Tzu-Shun Lin, Yi-Shih Ma, Shu-Fen Peng, Te-Chun Hsia, Yih-Dih Cheng, Chao-Lin Kuo, Jing-Gung Chung
ETHNOPHARMACOLOGICAL RELEVANCE: Bufalin, a component of Chan Su (frog), has been shown to have biological activities including anti-tumor effects. Gefitinib has been used as an anti-cancer drug in lung cancer patients; however, some patients eventually become gefitinib resistant. AIM OF THE STUDY: In this study, we investigated anti-metastasis effects of bufalin in gefitinib resistant NCI-H460 lung cancer cells. MATERIALS AND METHODS: The effects of the bufalin in gefitinib resistant NCI-H460 lung cancer cells were investigated on cell viability using flow cytometry...
November 7, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27832766/obesity-diet-quality-physical-activity-and-the-built-environment-the-need-for-behavioral-pathways
#19
Adam Drewnowski, Anju Aggarwal, Wesley Tang, Philip M Hurvitz, Jason Scully, Orion Stewart, Anne Vernez Moudon
BACKGROUND: The built environment (BE) is said to influence local obesity rates. Few studies have explored causal pathways between home-neighborhood BE variables and health outcomes such as obesity. Such pathways are likely to involve both physical activity and diet. METHODS: The Seattle Obesity Study (SOS II) was a longitudinal cohort of 440 adult residents of King Co, WA. Home addresses were geocoded. Home-neighborhood BE measures were framed as counts and densities of food sources and physical activity locations...
November 10, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27832193/postnatal-changes-in-tibial-bone-speed-of-sound-of-preterm-and-term-infants-during-infancy
#20
Hsiu-Lin Chen, Wei-Te Lee, Pei-Lun Lee, Po-Len Liu, Rei-Cheng Yang
This study aimed to evaluate changes in tibial bone speed of sound (SOS) over time, in preterm and term infants during infancy, in addition to identifying factors influencing the development of tibial SOS during infancy. Preterm (n = 155) and term (n = 65) infants were enrolled in this study. Tibial bone SOS was measured using quantitative ultrasonography (QUS) on the left tibia of newborn infants after birth (within 7 days), at 1 month old, and then every 2 months until subjects were approximately 12-15 months old...
2016: PloS One
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