keyword
MENU ▼
Read by QxMD icon Read
search

Relaxation response

keyword
https://www.readbyqxmd.com/read/29231948/a-tailored-nanosheet-decorated-with-a-metallized-dendrimer-for-angiography-and-magnetic-resonance-imaging-guided-combined-chemotherapy
#1
Guilong Zhang, Ruohong Du, Junchao Qian, Xiaojia Zheng, Xiaohe Tian, Dongqing Cai, Jiacai He, Yiqun Wu, Wei Huang, Yuanyin Wang, Xin Zhang, Kai Zhong, Duohong Zou, Zhengyan Wu
Considering the chemical exchange between gadolinium centers and water protons, nanosystems comprising gadolinium conjugated with high specific area nanocarriers might serve as more robust clinical tools for diagnosis and imaging-guided therapy. Herein, a pH-responsive nanosystem containing graphene oxide conjugated with a folic acid- and gadolinium-labeled dendrimer (FA-GCGLD) to boost its T1 contrast ability was developed, and doxorubicin (DOX) and colchicine (COLC) were efficiently loaded onto this nanosystem (FA-GCGLD-DOX/COLC)...
December 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/29230572/responsiveness-of-internal-thoracic-arteries-to-nitroglycerin-in-patients-with-renal-failure
#2
Masashi Tawa, Takeshi Kinoshita, Tohru Asai, Tomoaki Suzuki, Takaharu Ishibashi, Tomio Okamura
Nitroglycerin is commonly used as an antispasmodic for treating spasm of coronary artery bypass grafts. This study investigated whether the presence of renal failure affects reactivity to nitroglycerin in internal thoracic arteries obtained from patients undergoing coronary bypass surgery. The patients were divided into three groups according to estimated glomerular filtration rate (eGFR, mL/min/1.73 m2): without renal failure (60 ≤ eGFR, n = 13), with moderate renal failure (30 ≤ eGFR < 60, n = 10), and with severe renal failure (eGFR < 30, n = 10)...
December 11, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29223042/experiences-of-early-labour-management-from-perspectives-of-women-labour-companions-and-health-professionals-a-systematic-review-of-qualitative-evidence
#3
REVIEW
Sarah Beake Rm Ma Research Associate, Yan-Shing Chang Ba MPhil PhD Lecturer, Helen Cheyne Rm Rgn MSc PhD Professor Of Midwifery, Helen Spiby MPhil Rn Rm Professor Of Midwifery, Jane Sandall Rm MSc PhD Professor Of Social Science And Women's Health, Debra Bick
OBJECTIVES: to examine evidence of women's, labour companions' and health professionals' experiences of management of early labour to consider how this could be enhanced to better reflect women's needs. DESIGN: a systematic review of qualitative evidence. SETTING AND PARTICIPANTS: women in early labour with term, low risk singleton pregnancies, not booked for a planned caesarean birth or post-dates induction of labour, their labour companions, and health professionals responsible for early labour care (e...
November 13, 2017: Midwifery
https://www.readbyqxmd.com/read/29222635/cardiovascular-response-of-rat-aorta-to-di-2-ethylhexyl-phthalate-dehp-exposure
#4
Melissa Mariana, Joana Feiteiro, Elisa Cairrao
Phthalates are one of the main constituents of plastic, reaching up to 40% of the total plastic weight, and their main function is to impart flexibility/elasticity to polymers that would otherwise be rigid. Phthalates are known as endocrine disruptors, since they can interfere with hormone homeostasis. Regarding the cardiovascular system, it was already shown the effects of di-(2-ethylhexyl) phthalate (DEHP) exposure with significant changes in several calcium-handling proteins and an increase in the blood pressure of mice offspring, suggesting that DEHP leads to vasocontraction...
December 8, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29222423/voluntary-modulation-of-mental-effort-investment-an-fmri-study
#5
Omar T Khachouf, Gang Chen, Davide Duzzi, Carlo A Porro, Giuseppe Pagnoni
Mental effort is a common phenomenological construct deeply linked to volition and self-control. While it is often assumed that the amount of exertion invested in a task can be voluntarily regulated, the neural bases of such faculty and its behavioural effects are yet insufficiently understood. In this study, we investigated how the instructions to execute a demanding cognitive task either "with maximum exertion" or "as relaxed as possible" affected performance and brain activity. The maximum exertion condition, compared to relaxed execution, was associated with speeded motor responses without an accuracy trade-off, and an amplification of both task-related activations in dorsal frontoparietal and cerebellar regions, and task-related deactivations in default mode network (DMN) areas...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221378/theoretical-approaches-for-treating-non-valence-correlation-bound-anions
#6
Vamsee K Voora, Arailym Kairalapova, Thomas Sommerfeld, Kenneth D Jordan
In this work, we use a model (H2O)4 cluster, the bent CO2 molecule, and tetracyanoethylene as systems to explore the applicability of various electronic structure methods for characterizing non-valence correlation-bound anion states. The methods examined include the algebraic diagrammatic construction, various equation-of-motion coupled cluster methods, orbital-optimized MP2, and Brueckner coupled cluster doubles with perturbative triples. We demonstrate that the key to treating this challenging class of anions is the use of methods that include adequate orbital relaxation in response to long-range dispersion-like correlation effects...
December 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29220368/increased-sediment-load-during-a-large-scale-dam-removal-changes-nearshore-subtidal-communities
#7
Stephen P Rubin, Ian M Miller, Melissa M Foley, Helen D Berry, Jeffrey J Duda, Benjamin Hudson, Nancy E Elder, Matthew M Beirne, Jonathan A Warrick, Michael L McHenry, Andrew W Stevens, Emily F Eidam, Andrea S Ogston, Guy Gelfenbaum, Rob Pedersen
The coastal marine ecosystem near the Elwha River was altered by a massive sediment influx-over 10 million tonnes-during the staged three-year removal of two hydropower dams. We used time series of bathymetry, substrate grain size, remotely sensed turbidity, scuba dive surveys, and towed video observations collected before and during dam removal to assess responses of the nearshore subtidal community (3 m to 17 m depth). Biological changes were primarily driven by sediment deposition and elevated suspended sediment concentrations...
2017: PloS One
https://www.readbyqxmd.com/read/29218907/emergence-of-pathway-level-composite-biomarkers-from-converging-gene-set-signals-of-heterogeneous-transcriptomic-responses
#8
Samir Rachid Zaim, Qike Li, A Grant Schissler, Yves A Lussier
Recent precision medicine initiatives have led to the expectation of improved clinical decisionmaking anchored in genomic data science. However, over the last decade, only a handful of new single-gene product biomarkers have been translated to clinical practice (FDA approved) in spite of considerable discovery efforts deployed and a plethora of transcriptomes available in the Gene Expression Omnibus. With this modest outcome of current approaches in mind, we developed a pilot simulation study to demonstrate the untapped benefits of developing disease detection methods for cases where the true signal lies at the pathway level, even if the pathway's gene expression alterations may be heterogeneous across patients...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29217857/a-comparison-of-haemodynamic-responses-between-clinical-assessment-guided-tracheal-intubation-and-neuromuscular-block-monitoring-guided-tracheal-intubation-a-prospective-randomised-study
#9
Rudranil Nandi, Shekhar Ranjan Basu, Susanta Sarkar, Rakesh Garg
Background and Aims: Haemodynamic responses to laryngoscopy and endotracheal intubation and their hazards are well documented. The purpose of the study was to compare the effects of laryngoscopy and intubation on cardiovascular responses when the appropriate moment for intubation was directed by either clinical judgment or train-of-four assessment. Methods: A total of 68 patients, posted for laparoscopic cholecystectomy, were randomised into two groups. In Group M patients, the trachea was intubated after train of four counts became zero in adductor pollicis muscle, whereas in Group C patients, the trachea was intubated after the clinical judgment of jaw muscle relaxation...
November 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29215951/regulation-of-aqueous-humor-dynamics-by-hydrogen-sulfide-potential-role-in-glaucoma-pharmacotherapy
#10
Sunny E Ohia, Jenaye Robinson, Leah Mitchell, Kalu K Ngele, Segewkal Heruye, Catherine A Opere, Ya Fatou Njie-Mbye
Hydrogen sulfide (H2S) is a gaseous transmitter with well-known biological actions in a wide variety of tissues and organs. The potential involvement of this gas in physiological and pathological processes in the eye has led to several in vitro, ex vivo, and in vivo studies to understand its pharmacological role in some mammalian species. Evidence from literature demonstrates that 4 enzymes responsible for the biosynthesis of this gas (cystathionine β-synthase, CBS; cystathionine γ-lyase, CSE; 3-mercaptopyruvate sulfurtransferase, 3MST; and d-amino acid oxidase) are present in the cornea, iris, ciliary body, lens, and retina...
December 7, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29214391/stroking-and-tapping-the-skin-behavioral-and-electrodermal-effects
#11
Roberta Etzi, Carlotta Carta, Alberto Gallace
Being caressed represents one of the most typical expressions of affection conveyed by touch. Converging evidence suggests that the pleasant perception of gentle and slow stroking delivered to the hairy skin is mediated by C-Tactile afferents (CTs). While behavioral and neural responses to CT-optimal touch have been moderately explored so far, less is known about the autonomic reaction to different kinds of touch (both CT-optimal and not). Here, we investigated whether physiological arousal varies as a function of the specific tactile stimulation provided...
December 6, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29212858/decreased-edhf-mediated-relaxation-is-a-major-mechanism-in-endothelial-dysfunction-in-resistance-arteries-in-aged-mice-on-prolonged-high-fat-sucrose-diet
#12
Shannon M Dunn, Kumuda C Das
High-fat sucrose (HFS) diet in aged individuals causes severe weight gain (obesity) with much higher risk of cardiovascular diseases such as hypertension or atherosclerosis. Endothelial dysfunction is a major contributor for these vascular disorders. We hypothesize that prolonged ingestion of HFS diet by aged mice would accentuate endothelial dysfunction in the small resistance arteries. Male C57BL/6J mice at 12 weeks of age were divided into four groups and fed either normal chow (NC) or high-fat sucrose diet (HFS)...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29212831/impaired-pulmonary-arterial-vasoconstriction-and-nitric-oxide-mediated-relaxation-underlie-severe-pulmonary-hypertension-in-sugen-hypoxia-rat-model
#13
Helen Christou, Hannes Hudalla, Zoe Michael, Evgenia Filatava, Jun Li, Minglin Zhu, Jose Possomato-Vieira, Carlos Dias-Junior, Stella Kourembanas, Raouf A Khalil
Pulmonary vasoreactivity could determine the responsiveness to vasodilators and in turn the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and examined the underlying mechanisms, in the sugen-hypoxia rat model of severe PH. Male Sprague-Dawley rats were injected with sugen (20 mg/kg sc) and exposed to hypoxia (9% O2) for 3 weeks followed by 4 weeks in normoxia (Su/Hx), or treated with sugen alone (Su) or hypoxia alone (Hx) or neither (Nx). After hemodynamic measurements, the heart was assessed for right ventricular hypertrophy (Fulton's Index), the pulmonary artery, aorta and mesenteric arteries were isolated for vascular function studies, and contractile markers were measured in pulmonary artery using quantitative PCR...
December 6, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29211992/fluctuation-analysis-in-nonstationary-conditions-single-ca2-channel-current-in-pyramidal-neurons
#14
Christian Scheppach, Hugh P C Robinson
Fluctuation analysis is a method that allows measurement of the single-channel current of ion channels even when it is too small to be resolved directly with the patch-clamp technique. This is the case for voltage-gated calcium channels. They are present in all mammalian central neurons, controlling presynaptic release of transmitter, postsynaptic signaling, and synaptic integration. The amplitudes of their single-channel currents in a physiological concentration of extracellular calcium, however, are small and not well determined...
December 5, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29211472/tuning-the-viscoelastic-gel-transition-of-single-wall-carbon-nanotubes-embedded-in-ph-responsive-polyelectrolyte-solutions
#15
Atiđa Selmani, Antonio Tavera-Vazquez, Cristina Garza, Rolando C Castillo
We present the detailed rheological changes that occur when small quantities of single-wall carbon nanotubes are dispersed in a polyacrylic acid water solution, around the overlap polymer concentration, up to the gel point. Here, pH is used to tune the gel formation. Suspensions of nanotubes at pH ≤ 5 are exfoliated and dispersed by the polymer. Contacts between the nanotubes are mainly through polymer entangling, and the suspension is viscoelastic. At pH > 5, the polymer is charged, and the solution is not so good solvent for the nanotubes anymore...
December 6, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29210673/detecting-beta-amyloid-aggregation-from-the-time-resolved-emission-spectra
#16
Abeer Alghamdi, Vladislav Vyshemirsky, David J S Birch, Olaf J Rolinski
Aggregation of beta-amyloids is one of key processes responsible for the development of Alzheimer's desease. Early molecular-level detection of beta-amyloid oligomers may help in early diagnosis and in the development of new intervention therapies. Our previous studies on changes in beta-amyloid's single tyrosine intrinsic fluorescence response during aggregation demonstrated a four-exponential fluorescence intensity decay, and that the ratio of the pre-exponential factors indicated the extent of aggregation in the early stages of the process before the beta-sheets are formed...
December 6, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/29210559/a-multifunctional-phpma-derived-polymer-for-ratiometric-ph-sensing-fluorescence-imaging-and-magnetic-resonance-imaging
#17
Fengyu Su, Shubhangi Agarwal, Tingting Pan, Yuan Qiao, Liqiang Zhang, Zhengwei Shi, Xiangxing Kong, Kevin Day, Meiwan Chen, Deirdre R Meldrum, Vikram D Kodibagkar, Yanqing Tian
In this paper we report synthesis and characterization of a novel multi-modality (MRI/Fluorescence) probe for pH sensing and imaging. A multifunctional polymer was derived from poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA) and integrated with a naphthalimide-based-ratiometric fluorescence probe and a gadolinium -1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complex (Gd-DOTA complex). The polymer was characterized using UV-vis absorption spectrophotometer, fluorescence spectrofluophotometer, magnetic resonance imaging (MRI), and confocal microscopy for optical and MRI-based pH sensing, and cellular imaging...
December 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29203816/re-entrant-spin-glass-transitions-new-insights-from-acoustic-absorption-by-domain-walls
#18
S Kustov, J Torrens-Serra, E K H Salje, D N Beshers
Re-entrant spin glass (RSG) transitions in Ni-Mn and Au-Fe have been reassessed by acoustic measurements of the magneto-mechanical damping by domain walls. Stress-induced non-thermally activated domain wall dynamics is progressively replaced by an intense thermally activated relaxational response when the temperature approaches the RSG freezing point. A "frozen" state with negligible motion of domain walls on atomic and mesoscopic scales occurs in the RSG. We propose that RSG freezing has its origin in intrinsic properties of domain walls...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29200561/efficacy-of-adjunctive-single-session-counseling-for-medically-unexplained-symptoms-a-randomized-controlled-trial
#19
Vikas Menon, Balasubramanian Shanmuganathan, Jaiganesh Selvapandian Thamizh, Anand Babu Arun, Siddharth Sarkar
Context: Medically unexplained symptoms (MUS) are often poorly responsive to standard treatments. Aim: The aim of the study is to assess short-term efficacy of adjunctive single session cognitive behavior therapy (CBT)-based counseling for patients with MUS. Setting and Design: Randomized controlled trial at a psychosomatic clinic of a tertiary care hospital. Materials and Methods: Patients with MUS were randomized to receive either the single session counseling (intervention group) (n = 41) or control group which received treatment as usual (n = 35)...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29200286/ligand-effect-on-the-single-molecule-magnetism-of-tetranuclear-co-ii-cubane
#20
Xiong-Feng Ma, Zhenxing Wang, Xue-Li Chen, Mohamedally Kurmoo, Ming-Hua Zeng
A clear dependence on the ligand has been observed for the magnetic properties of a closely related series of Co(II) cubane structures, viz. [Co4(mbm or bm)4(ROH)4Br4] (1-MeOH, 1-EtOH, 2-MeOH, and 2-EtOH, where 1 = [Co4(mbm)4Br4], 2 = [Co4(bm)4Br4], bm = (1H-benzo[d]imidazol-2-yl)methanolate. and mbm = 1-Me-bm.) The [Co4(OR)4] cubane core consists of an octahedral CoII center chelated by the alkoxide oxygen and imidazole nitrogen atoms from monoanionic bm or mbm and coordinated by methanol/alcohol and bromine...
December 4, 2017: Inorganic Chemistry
keyword
keyword
85844
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"