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Relaxation response

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https://www.readbyqxmd.com/read/29034007/microfluidic-iterative-mechanical-characteristics-imech-analyzer-for-single-cell-metastatic-identification
#1
Hesam Babahosseini, Jeannine S Strobl, Masoud Agah
This study describes the development of a microfluidic biosensor called the iterative mechanical characteristics (iMECH) analyzer which enables label-free biomechanical profiling of individual cells for distinction between metastatic and non-metastatic human mammary cell lines. Previous results have demonstrated that pulsed mechanical nanoindentation can modulate the biomechanics of cells resulting in distinctly different biomechanical responses in metastatic and non-metastatic cell lines. The iMECH analyzer aims to move this concept into a microfluidic, clinically more relevant platform...
February 7, 2017: Analytical Methods: Advancing Methods and Applications
https://www.readbyqxmd.com/read/29032948/anxiety-and-pain-related-to-mandibular-block-injections-comparison-of-self-reported-measures-and-physiological-response
#2
Jacco G Tuk, Jerome A Lindeboom, Linda Hoogendoorn, Byron W Taylor, Arjen J van Wijk
OBJECTIVE: The aim of this study was to determine whether patients with a pain score ≥7 (high pain group) after a mandibular block injection had a higher physiologic response compared with patients with scores <7 (low pain group). STUDY DESIGN: Before oral surgery, patients (n = 66) filled out questionnaires to measure anxiety and expected pain. The questionnaires also assessed patients' experiences with dental injections and dental anxiety, as well as their emotional state and intensity of anxiety...
September 6, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29031792/control-of-myogenic-tone-and-agonist-induced-contraction-of-intramural-coronary-resistance-arterioles-by-cannabinoid-type-1-receptors-and-endocannabinoids
#3
Mária Szekeres, György L Nádasy, Eszter Soltész-Katona, László Hunyady
It was tested whether intrinsic CB1R activation modifies myogenic and agonist induced contraction of intramural coronary resistance arteries of the rat. CB1R protein was detected by immuno-histochemistry and by Western blot, its mRNA by qRT-PCR in their wall. Microsurgically prepared cylindrical coronary segments (∼100-150μm) developed myogenic contraction (∼20% of relaxed luminal diameter), from which a substantial relaxation (∼15%) in response to WIN55212 (a specific agonist of the CB1Rs) has been found...
October 12, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29030402/transcriptome-and-functional-profile-of-cardiac-myocytes-is-influenced-by-biological-sex
#4
Christa L Trexler, Aaron T Odell, Mark Y Jeong, Robin D Dowell, Leslie A Leinwand
BACKGROUND: Although cardiovascular disease is the primary killer of women in the United States, women and female animals have traditionally been omitted from research studies. In reports that do include both sexes, significant sexual dimorphisms have been demonstrated in development, presentation, and outcome of cardiovascular disease. However, there is little understanding of the mechanisms underlying these observations. A more thorough understanding of sex-specific cardiovascular differences both at baseline and in disease is required to effectively consider and treat all patients with cardiovascular disease...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29030338/estrogen-replacement-attenuates-stress-induced-pressor-responses-through-vasorelaxation-via-%C3%AE-2-adrenoceptor-in-peripheral-arteries-of-ovariectomized-rats
#5
Shoko Tazumi, Sayo Omoto, Yu Nagatomo, Mariko Kawahara, Naoko Yokota, Mizuho Kawakami, Akira Takamata, Keiko Morimoto
We examined whether chronic estrogen replacement has an inhibitory effect on stress-induced pressor responses via activation of β2-adrenoceptor (AR) in peripheral arteries of ovariectomized rats. Female Wistar rats aged 9 weeks were ovariectomized. After 4 weeks, pellets containing either 17β-estradiol (E2) or placebo (Pla) were subcutaneously implanted into the rats. After 4 weeks of treatment, the rats underwent cage-switch stress and, in a separate experiment, a subset received an infusion of isoproterenol (ISO), with or without pretreatment with β1-AR blocker, atenolol or β2-AR blocker, butoxamine...
October 13, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29028062/residual-stresses-in-colloidal-gels
#6
Esmaeel Moghimi, Alan R Jacob, George Petekidis
A combination of experiments and Brownian Dynamics (BD) simulations is utilized to examine internal stresses in colloidal gels brought to rest from steady shear at different shear rates. A model colloidal gel with intermediate volume fraction is chosen where attractions between particles are introduced by adding non-adsorbing linear polymer chains. After flow cessation, the gel releases the stress in two distinct patterns: at high shear rates, where shear forces dominate over attractive forces, the shear-melted gel behaves as a liquid and releases stresses to zero after flow cessation...
October 13, 2017: Soft Matter
https://www.readbyqxmd.com/read/29027818/effects-of-nesfatin-1-on-atrial-contractility-and-thoracic-aorta-reactivity-in-male-rats
#7
Ayşe Barutcigil, Arda Tasatargil
BACKGROUND: This study aimed to examine the effects of nesfatin-1 on thoracic aorta vasoreactivity and to investigate the inotropic and chronotropic effects of nesfatin-1 on the spontaneous contractions of the isolated rat atria. METHODS: Isolated right atria and thoracic aorta were used in organ baths. The reactivity of the thoracic aorta was evaluated by potassium chloride (KCl), phenylephrine (Phe), acetylcholine (ACh), and sodium nitroprusside (SNP). The effects of nesfatin-1 on the spontaneous contractions of the rat atria were also examined...
October 13, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29026107/achilles-tendon-compositional-and-structural-properties-are-altered-after-unloading-by-botox
#8
Hanifeh Khayyeri, Parmis Blomgran, Malin Hammerman, Mikael J Turunen, Annika Löwgren, Manuel Guizar-Sicairos, Per Aspenberg, Hanna Isaksson
Tendon function and homeostasis rely on external loading. This study investigates the biological mechanisms behind tendon biomechanical function and how the mechanical performance is affected by reduced daily loading. The Achilles tendons of 16 weeks old female Sprague Dawley rats (n = 40) were unloaded for 5 weeks by inducing muscle paralysis with botulinum toxin injections in the right gastrocnemius and soleus muscles. The contralateral side was used as control. After harvest, the tendons underwent biomechanical testing to assess viscoelasticity (n = 30 rats) and small angle X-ray scattering to determine the structural properties of the collagen fibrils (n = 10 rats)...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024691/mechanisms-involved-in-the-increased-sensitivity-of-the-rabbit-basilar-artery-to-atrial-natriuretic-peptide-in-diabetes
#9
Mikahela A López-Morales, José M Centeno, Teresa Jover-Mengual, Vannina G Marrachelli, María C Burguete, María Castelló-Ruiz, Alicia Aliena-Valero, Enrique Alborch, Germán Torregrosa, Juan B Salom, Francisco J Miranda
Atrial natriuretic peptide (ANP) is a vasodilator with significant regional differences and controversial effects in the cerebral circulation, a vascular bed particularly prone to diabetes-induced complications. The present study has investigated how alloxan-induced diabetes modifies the mechanisms involved in the response of the rabbit basilar artery to ANP. ANP (10(-12)-10(-7)M) relaxed precontracted basilar arteries, with higher potency in diabetic than in control rabbits. In arteries from both groups of animals, endothelium removal reduced ANP-induced relaxations...
October 9, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29024086/combined-endogenous-mr-biomarkers-to-predict-basal-tumor-oxygenation-and-response-to-hyperoxic-challenge
#10
Thanh-Trang Cao-Pham, Nicolas Joudiou, Matthias Van Hul, Caroline Bouzin, Patrice D Cani, Bernard Gallez, Bénédicte F Jordan
Hypoxia is a common feature of solid tumors, which translates into increased angiogenesis, malignant phenotype cell selection, change in gene expression and greater resistance to radiotherapy and chemotherapy. Therefore, there is a need for markers of hypoxia to stratify patients, in order to personalize treatment to improve therapeutic outcome. However, no modality has yet been validated for the screening of hypoxia in routine clinical practice. Magnetic resonance imaging (MRI) R1 and R2 * relaxation parameters are sensitive to tissue oxygenation: R1 is sensitive to dissolved oxygen and R2 * is sensitive to intravascular deoxyhemoglobin content...
October 11, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29023735/shortening-of-an-existing-generic-online-health-related-quality-of-life-instrument-for-dogs
#11
J Reid, L Wiseman-Orr, M Scott
OBJECTIVE: Development, initial validation and reliability testing of a shortened version of a web-based questionnaire instrument to measure generic health-related quality of life in companion dogs, to facilitate smartphone and online use. MATERIALS AND METHODS: The original 46 items were reduced using expert judgment and factor analysis. Items were removed on the basis of item loadings and communalities on factors identified through factor analysis of responses from owners of healthy and unwell dogs, intrafactor item correlations, readability of items in the UK, USA and Australia and ability of individual items to discriminate between healthy and unwell dogs...
October 11, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29020956/guaiphenesin-ketamine-xylazine-infusion-to-maintain-anesthesia-in-mules-undergoing-field-castration
#12
Cecilia Vullo, Augusto Carluccio, Domenico Robbe, Marina Meligrana, Linda Petrucci, Giuseppe Catone
BACKGROUND: In order to determine whether a combination of guaiphenesin, ketamine and xylazine can induce safe and satisfactory anaesthesia in mules undergoing field castration, eight healthy adult intact male mules were employed. They were premedicated with intravenous (IV) xylazine (1.3 mg/kg); an additional dose of xylazine (0.3 mg/kg IV) was administered in case of inadequate depth of sedation. Anaesthesia was induced with IV thiopental (6 mg/kg). The quality of sedation and induction was recorded...
October 11, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29019442/the-use-of-hamstring-fatigue-to-reduce-quadriceps-inhibition-after-anterior-cruciate-ligament-reconstruction
#13
Timothy Lowe, Xuanliang Neil Dong
Arthrogenic muscle inhibition, an inability to fully activate the quadriceps muscles, has been persistently observed after anterior cruciate ligament reconstruction (ACLr) surgery. Reductions in quadriceps activation may be partly due to the flexion reflex pathway, hamstrings activation, and reciprocal quadriceps inhibition. Since central fatigue has been shown to modify hamstring excitability and change the hamstring reflex response, hamstring fatigue might alleviate quadriceps muscle inhibition by counteracting the flexion reflex...
January 1, 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/29019368/quasielastic-neutron-scattering-study-of-microscopic-dynamics-in-polybutadiene-reinforced-with-an-unsaturated-carboxylate
#14
Ryo Mashita, Rintaro Inoue, Taiki Tominaga, Kaoru Shibata, Hiroyuki Kishimoto, Toshiji Kanaya
We studied the dynamics of zinc diacrylate (ZDA) reinforced polybutadiene rubber (BR) (ZDA/BR) using the quasielastic neutron scattering technique to determine the effect of concentration of ZDA on polymer dynamics. First, we evaluated the temperature dependence of mean square displacements (〈u(2)〉) for ZDA/BR with different ZDA volume fractions. 〈u(2)〉 increased with temperature below 170 K, and we observed no significant ZDA volume fraction dependence. However, it increased more steeply above 170 K, and the value of 〈u(2)〉 was smaller for the samples with increasing ZDA fraction...
October 11, 2017: Soft Matter
https://www.readbyqxmd.com/read/29018025/peptidyl-prolyl-isomerase-1-regulates-ca-2-handling-by-modulating-sarco-endo-plasmic-reticulum-calcium-atpase-and-na-2-ca-2-exchanger-1-protein-levels-and-function
#15
Veronica Sacchi, Bingyan J Wang, Dieter Kubli, Alexander S Martinez, Jung-Kang Jin, Roberto Alvarez, Nirmala Hariharan, Christopher Glembotski, Takafumi Uchida, James S Malter, Yijun Yang, Polina Gross, Chen Zhang, Steven Houser, Marcello Rota, Mark A Sussman
BACKGROUND: Aberrant Ca(2+) handling is a prominent feature of heart failure. Elucidation of the molecular mechanisms responsible for aberrant Ca(2+) handling is essential for the development of strategies to blunt pathological changes in calcium dynamics. The peptidyl-prolyl cis-trans isomerase peptidyl-prolyl isomerase 1 (Pin1) is a critical mediator of myocardial hypertrophy development and cardiac progenitor cell cycle. However, the influence of Pin1 on calcium cycling regulation has not been explored...
October 10, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29016945/fluctuating-light-acclimation-protein1-conserved-in-oxygenic-phototrophs-regulates-h-homeostasis-and-non-photochemical-quenching-in-chloroplasts
#16
Ryoichi Sato, Masaru Kono, Kyohei Harada, Hiroyuki Ohta, Shinichi Takaichi, Shinji Masuda
Plants have mechanisms allowing them to acclimate to intense light conditions, which involves the dissipation of excess light energy. These mechanisms allow plants to perform photosynthesis efficiently and, therefore, must be accurately and precisely controlled. However, how plants dissipate excess light energy has yet to be fully elucidated. Herein we report the identification of a gene, which we named Fluctuating-Light-Acclimation Protein1 (FLAP1), that is conserved in oxygenic phototrophs. We show that Arabidopsis FLAP1 is associated with chloroplast thylakoid and envelope membranes and that the flap1 mutant shows delayed non-photochemical quenching (NPQ) relaxation during induction of photosynthesis at moderate light intensity...
September 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28992602/the-viscoelastic-response-of-electrospun-poly-vinyl-alcohol-mats
#17
Sana Waheed, Annabel L Butcher, Michelle L Oyen
Native biological tissues are viscoelastic materials that undergo time-dependent loading in vivo. It is therefore crucial to ensure that biomedical materials have a suitable viscoelastic response for a given application. In this study, the viscoelastic properties of electrospun poly(vinyl alcohol) are investigated using tensile load relaxation testing. A five-parameter generalised Maxwell constitutive model is found to characterise the experimental response. The effect of polymer concentration and electrospinning voltage on model parameters is investigated in detail...
September 23, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28992447/magnetic-hyperthermia-efficiency-and-mri-contrast-sensitivity-of-colloidal-soft-hard-ferrite-nanoclusters
#18
Kosmas Vamvakidis, Stefanos Mourdikoudis, Antonis Makridis, Eleni Paulidou, Mavroeidis Angelakeris, Catherine Dendrinou-Samara
The use of magnetic nanostructures as theranostic agents is a multiplex task as physiochemical and biochemical properties including excellent magneto-responsive properties, low toxicity, colloidal stability and facile surface engineering capability are all required. Nonetheless, much progress has been made in recent years synthesis of "all-in-one" MNPs remain unambiguously challenging. Towards this direction, in this study is presented a facile incorporation of a soft magnetic phase (MnFe2O4 NPs) with a hard phase (CoFe2O4 NPs) in the presence of the biocompatible polymer sodium dodecyl sulfate (SDS), into spherical and compact bi-magnetic nanoclusters (NCs) with modulated magnetic properties that critically enhance hyperthermic efficiency and MRI contrast effect...
October 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28992349/singing-and-vocal-interventions-in-palliative-and-cancer-care-music-therapists-perceptions-of-usage
#19
Amy Clements-Cortés
Background: Music therapists in palliative and cancer care settings often use singing and vocal interventions. Although benefits for these interventions are emerging, more information is needed on what type of singing interventions are being used by credentialed music therapists, and what goal areas are being addressed. Objective: To assess music therapists' perceptions on how they use singing and vocal interventions in palliative and cancer care environments. Method: Eighty credentialed music therapists from Canada and the United States participated in this two-part convergent mixed-methods study that began with an online survey, followed by individual interviews with 50% (n = 40) of the survey participants...
September 8, 2017: Journal of Music Therapy
https://www.readbyqxmd.com/read/28989912/effect-of-low-dose-atracurium-on-laryngeal-mask-airway-insertion-conditions-a-randomized-double-blind-clinical-trial
#20
Karim Nasseri
BACKGROUND: The amount of sedation and muscle relaxation of the jaw may have an impact on complications caused by laryngeal mask airway (LMA). The aim of this study is to evaluate the effect of low-dose Atracurium on conditions of insertion, complications, and hemodynamic responses to LMA insertion following induction of anesthesia with propofol, in patients undergoing cataract surgery. PATIENTS AND METHODS: In this double-blind randomized clinical trial study, 60 patients were randomly divided into two groups...
2017: Advanced Biomedical Research
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