keyword
MENU ▼
Read by QxMD icon Read
search

Relaxation response

keyword
https://www.readbyqxmd.com/read/28433656/impaired-endothelium-derived-hyperpolarization-type-relaxation-in-superior-mesenteric-arteries-isolated-from-female-otsuka-long-evans-tokushima-fatty-rats
#1
Takayuki Matsumoto, Shota Kobayashi, Makoto Ando, Shun Watanabe, Maika Iguchi, Kumiko Taguchi, Tsuneo Kobayashi
Endothelium-derived hyperpolarization (EDH) is an important signaling mechanism of endothelium-dependent vasorelaxation, and little attention has been paid to the EDH-type responses in female metabolic syndrome such as that observed with type-2 diabetes. We previously reported that EDH-type relaxation was impaired in superior mesenteric arteries from male Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a model of type-2 diabetes, however, the response was unclear in female OLETF rat. Thus, the aim of this study was to examine if EDH-type relaxation was altered in superior mesenteric arteries isolated from female OLETF rats compared to age-matched, control female Long-Evans Tokushima Otsuka (LETO) rats at age 50-59 weeks...
April 19, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28433033/model-for-the-alpha-and-beta-shear-mechanical-properties-of-supercooled-liquids-and-its-comparison-to-squalane-data
#2
Tina Hecksher, Niels Boye Olsen, Jeppe C Dyre
This paper presents data for supercooled squalane's frequency-dependent shear modulus covering frequencies from 10 mHz to 30 kHz and temperatures from 168 K to 190 K; measurements are also reported for the glass phase down to 146 K. The data reveal a strong mechanical beta process. A model is proposed for the shear response of the metastable equilibrium liquid phase of supercooled liquids. The model is an electrical equivalent-circuit characterized by additivity of the dynamic shear compliances of the alpha and beta processes...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28433012/internal-dynamics-of-semiflexible-polymers-with-active-noise
#3
Thomas Eisenstecken, Gerhard Gompper, Roland G Winkler
The intramolecular dynamics of flexible and semiflexible polymers in response to active noise is studied theoretically. The active noise may either originate from interactions of a passive polymer with a bath of active Brownian particles or the polymer itself is comprised of active Brownian particles. We describe the polymer by the continuous Gaussian semiflexible-polymer model, taking into account the finite polymer extensibility. Our analytical calculations predict a strong dependence of the polymer dynamics on the activity...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28432058/mk5-haplodefficiency-attenuates-hypertrophy-and-preserves-diastolic-function-during-remodeling-induced-by-chronic-pressure-overload-in-the-mouse-heart
#4
Sherin Nawaito, Dharmendra Dingar, Pramod Sahadevan, Bahira Hussein, Fatiha Sahmi, Yanfen Shi, Marc-Antoine Gillis, Matthias Gaestel, Jean-Claude Tardif, Bruce G Allen
MK5 is a protein serine and threonine kinase that is activated by p38 MAPK and the atypical MAPKs ERK3 and ERK4. The physiological function(s) of MK5 remain unknown. Herein we examine the effect of MK5 haplodeficiency on cardiac function and myocardial remodeling. At 12-weeks of age, MK5 haplodeficient mice (MK5(+/-)) were smaller than age-matched wild-type litter mates (MK5(+/+)), with similar diastolic function but reduced systolic function. Transverse aortic constriction (TAC) was employed to induce a chronic pressure overload in twelve-week-old male MK5(+/-) and MK5(+/+) mice...
April 21, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28428070/no-production-and-potassium-channels-activation-induced-by-crotalus-durissus-cascavella-underlie-mesenteric-artery-relaxation
#5
S S Santos, R L C Jesus, L O Simões, W P Vasconcelos, I A Medeiros, R C Veras, L L Casais-E-Silva, D F Silva
Animal toxins are natural resources for pharmacological studies. The venom of Crotalus durissus cascavella (C.d. cascavella) may be a source in the bio-prospecting of new anti-hypertensive agents. The aim of this study was to investigate vascular effects of the venom of C.d. cascavella in normotensive rats. Studies were performed using isolated mesenteric artery segments and aortic endothelial cells. The cumulative administration of the venom of C.d. cascavella (0.001-30 μg/mL) on phenylephrine (Phe; 10 μM) pre-contracted rings induced a concentration-dependent vasorelaxation in the presence of vascular endothelium (Emax = 47...
April 17, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28428008/force-development-and-intracellular-ca-2-in-intact-cardiac-muscles-from-gravin-mutant-mice
#6
Zhitao Li, Sonal Singh, Santosh V Suryavanshi, Wengang Ding, Xiaoxu Shen, Cori S Wijaya, Wei Dong Gao, Bradley K McConnell
Gravin (AKAP12) is an A-kinase-anchoring-protein that scaffolds protein kinase A (PKA), β2-adrenergic receptor (β2-AR), protein phosphatase 2B and protein kinase C. Gravin facilitates β2-AR-dependent signal transduction through PKA to modulate cardiac excitation-contraction coupling and its removal positively affects cardiac contraction. Trabeculae from the right ventricles of gravin mutant (gravin-t/t) mice were employed for force determination. Simultaneously, corresponding intracellular Ca(2+) transient ([Ca(2+)]i) were measured...
April 17, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28425524/excited-state-relaxation-processes-of-h2-evolving-ru-pd-supramolecular-photocatalysts-containing-a-linear-or-non-linear-bridge-a-dft-and-tddft-study
#7
Jun Cao, Yun Zhou
In this study, the early-time excited state relaxation processes of bimetallic Ru-Pd supramolecular photocatalysts containing a linear 2,2':5',2''-terpyridine or a nonlinear 2,2':6',2''-terpyridine bridging ligand (BL) were investigated by density functional theory (DFT) and time-dependent DFT (TDDFT) approaches. The bridge based metal-to-ligand charge transfer triplet ((3)MLCT) state of the metal complex containing a linear bridging ligand was calculated to be the lowest energy triplet (T1) state which is closely related to the photocatalytic H2 production, while for that having a nonlinear bridging ligand, the T1 state is a Ru metal-centered (MC) triplet ((3)MCRu) state that is short-lived and rapidly decays to the ground electronic state (S0)...
April 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28425264/rho-rho-kinase-signalling-in-chronically-alcohol-fed-mice
#8
Havva Kubat, Ahmet Sencer Yurtsever, Kansu Büyükafşar
BACKGROUND/AIM: The effects of chronic ethanol consumption on male sexual function are debateable, and its effects on the Rho/Rho-kinase pathway are unknown. Therefore, we investigated smooth muscle reactivity and Rho/Rho-kinase signalling in the corpus cavernosum of ethanol-fed mice. MATERIALS AND METHODS: Ethanol was added to drinking water at 5% concentration in the first 2 days with 5% increment every subsequent 2 days, up to a final concentration of 20% for 45 days...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28424953/treatment-update-of-chronic-migraine
#9
REVIEW
Soo-Jin Cho, Tae-Jin Song, Min Kyung Chu
PURPOSE OF REVIEW: Although chronic migraine (CM) is a common disorder that severely impacts patient functioning and quality of life, it is usually underdiagnosed, and treatment responses often remain poor even after diagnosis. In addition, effective treatment options are limited due to the rarity of randomized controlled trials (RCTs) involving patients with CM. In the present review, we discuss updated pharmacological, non-pharmacological, and neurostimulation treatment options for CM...
June 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28424847/characterization-of-microtubule-buckling-in-living-cells
#10
Carla Pallavicini, Alejandro Monastra, Nicolás González Bardeci, Diana Wetzler, Valeria Levi, Luciana Bruno
Microtubules are filamentous biopolymers involved in essential biological processes. They form key structures in eukaryotic cells, and thus it is very important to determine the mechanisms involved in the formation and maintenance of the microtubule network. Microtubule bucklings are transient and localized events commonly observed in living cells and characterized by a fast bending and its posterior relaxation. Active forces provided by molecular motors have been indicated as responsible for most of these rapid deformations...
April 19, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28423119/importance-of-serca2a-on-early-isolated-diastolic-dysfunction-induced-by-supravalvular-aortic-stenosis-in-rats
#11
C F S M P Silveira, D H S Campos, P P Freire, A F Deus, K Okoshi, C R Padovani, A C Cicogna
Cardiac remodeling is defined as changes in shape and function of the heart in response to aggression (pressure overload). The sarcoplasmic reticulum calcium ATPase cardiac isoform 2a (SERCA2a) is a known factor that influences function. A wide spectrum of studies report a decrease in SERCA2a in heart failure, but none evaluate it's the role in early isolated diastolic dysfunction in supravalvular aortic stenosis (AoS). Our hypothesis was that SERCA2a participates in such dysfunction. Thirty-day-old male Wistar rats (60-80 g) were divided into AoS and Sham groups, which were submitted to surgery with or without aorta clipping, respectively...
April 13, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28418259/signature-of-congregated-effects-of-mechanical-and-electrical-anharmonicities-fermi-resonances-and-dampings-on-the-ir-spectra-of-hydrogen-bonded-systems-quantum-dynamic-study
#12
Najeh Rekik
Theoretical IR spectral density of the high-frequency stretching mode of hydrogen bond (H-bond) systems is reported using a three-dimensional approach. The model, studied within the framework of linear response theory, involves the mechanical anharmonicity of the high-frequency stretching mode by contemplating its potential as an asymmetric double well potential, the mechanical anharmonicity of the H-bond Bridge by contemplating its potential as a Morse potential, Fermi resonances which occur between the high frequency stretching mode and the overtones of the bending modes, the electrical anharmonicity translated by the non-linearity to second order in the electric dipole moment function of the fast mode, the second order modulation of the angular frequency and the equilibrium position of the fast mode on the slow mode coordinate, and direct and indirect relaxation mechanism...
April 18, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28417702/quinolone-resistance-associated-amino-acid-substitutions-affect-enzymatic-activity-of-mycobacterium-leprae-dna-gyrase
#13
Tomoyuki Yamaguchi, Kazumasa Yokoyama, Chie Nakajima, Yasuhiko Suzuki
Quinolones are important antimicrobials for treatment of leprosy, a chronic infectious disease caused by Mycobacterium leprae. Although it is well known that mutations in DNA gyrase are responsible for quinolone resistance, the effect of those mutations on the enzymatic activity is yet to be studied in depth. Hence, we conducted in vitro assays to observe supercoiling reactions of wild type and mutated M. leprae DNA gyrases. DNA gyrase with amino acid substitution Ala91Val possessed the highest activity among the mutants...
April 18, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28416926/the-role-of-cyclooxygenase-enzymes-in-the-effects-of-losartan-and-lisinopril-on-the-contractions-of-rat-thoracic-aorta
#14
Fikriye Yasemin Ozatik, Bilgin Kaygisiz, Kevser Erol
OBJECTIVE: It was suggested that prostaglandins which are synthesized by cyclooxygenase (COX) enzymes contribute to the actions of angiotensin-converting enzyme (ACE) inhibition and angiotensin AT1 receptor antagonism and there is an interaction between ACE signaling pathway and COX enzymes. We aim to investigate the role of COX enzymes in the effects of losartan, an angiotensin II (Ang II) receptor antagonist or lisinopril, an ACE inhibitor, on the contractions of rat thoracic aorta in isolated tissue bath...
February 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28415244/effect-of-the-salt-induced-micellar-microstructure-on-the-nonlinear-shear-flow-behavior-of-ionic-cetylpyridinium-chloride-surfactant-solutions
#15
D Gaudino, R Pasquino, H Kriegs, N Szekely, W Pyckhout-Hintzen, M P Lettinga, N Grizzuti
The shear flow dynamics of linear and branched wormlike micellar systems based on cetylpyridinium chloride and sodium salicylate in brine solution is investigated through rheometric and scattering techniques. In particular, the flow and the structural flow response are explored via velocimetry measurements and rheological and rheometric small-angle neutron scattering (SANS) experiments, respectively. Although all micellar solutions display a similar shear thinning behavior in the nonlinear regime, the experimental results show that shear banding sets in only when the micelle contour length L[over ¯] is sufficiently long, independent of the nature of the micellar connections (either linear or branched micelles)...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28414910/an-efficient-criterion-to-evaluate-linear-response-theory-in-optical-transitions
#16
Tanping Li
We deeply explore the role of the Gaussian statistics on the solvation dynamics upon the photon excitation of the chromophore. The linear response theory for the fluorescence Stokes shift is investigated. An analytical formulism is presented to recast Stokes shift into the contributions of the equilibrium time correlation functions of the solute-solvent interactions on the excited state surface, and the latter is further reformed and depicted by the time relaxation of the moment. As the first application of our formulism in the molecular dynamics simulations, we verify that the efficiency of the linear response theory relies on the Gaussian characteristics of the dominant moments in terms of the Stokes shift, which is identified by the same relaxation dynamics between those moments and the linear order one...
April 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28414741/effects-of-music-on-arousal-during-imagery-in-elite-shooters-a-pilot-study
#17
Garry Kuan, Tony Morris, Peter Terry
Beneficial effects of music on several performance-related aspects of sport have been reported, but the processes involved are not well understood. The purpose of the present study was to investigate effects of relaxing and arousing classical music on physiological indicators and subjective perceptions of arousal during imagery of a sport task. First, appropriate music excerpts were selected. Then, 12 skilled shooters performed shooting imagery while listening to the three preselected music excerpts in randomized order...
2017: PloS One
https://www.readbyqxmd.com/read/28414104/the-role-of-enos-on-the-compensatory-regulation-of-vascular-tonus-by-h2s-in-mouse-carotid-arteries
#18
Elif Ertuna, Annemarieke E Loot, Ingrid Fleming, Gunay Yetik-Anacak
The gasotransmitter nitric oxide (NO) has an important role in vascular function and a decrease in its bioavailability is accepted as a main pathological mechanism for cardiovascular diseases. However, other gasotransmitters such as hydrogen sulfide (H2S) are also generated by the endothelium and can also affect vascular tone and a crosstalk may exist between H2S and NO. We therefore investigated the consequences of deficiency, replacement or overexpression of endothelial nitric oxide synthase (eNOS) on H2S-induced vascular responses in murine carotid arteries...
April 13, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28413728/mechanism-of-endothelial-nitric-oxide-synthase-phosphorylation-and-activation-by-tentacle-extract-from-the-jellyfish-cyanea-capillata
#19
Beilei Wang, Dan Liu, Chao Wang, Qianqian Wang, Hui Zhang, Guoyan Liu, Xia Tao, Liming Zhang
Our previous study demonstrated that tentacle extract (TE) from the jellyfish Cyanea capillata (C. capillata) could cause a weak relaxation response mediated by nitric oxide (NO) using isolated aorta rings. However, the intracellular mechanisms of TE-induced vasodilation remain unclear. Thus, this study was conducted to examine the role of TE on Akt/eNOS/NO and Ca(2+) signaling pathways in human umbilical vein endothelial cells (HUVECs). Our results showed that TE induced dose- and time-dependent increases of eNOS activity and NO production...
2017: PeerJ
https://www.readbyqxmd.com/read/28412953/quantification-of-task-dependent-cortical-activation-evoked-by-robotic-continuous-wrist-joint-manipulation-in-chronic-hemiparetic-stroke
#20
Martijn P Vlaar, Teodoro Solis-Escalante, Julius P A Dewald, Erwin E H van Wegen, Alfred C Schouten, Gert Kwakkel, Frans C T van der Helm
BACKGROUND: Cortical damage after stroke can drastically impair sensory and motor function of the upper limb, affecting the execution of activities of daily living and quality of life. Motor impairment after stroke has been thoroughly studied, however sensory impairment and its relation to movement control has received less attention. Integrity of the somatosensory system is essential for feedback control of human movement, and compromised integrity due to stroke has been linked to sensory impairment...
April 17, 2017: Journal of Neuroengineering and Rehabilitation
keyword
keyword
85844
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"