Daniella Guedes de Figueiredo Lopes, Érica Fernanda Patricio, Neuza Maria Souza Picorelli Assis, Cláudia Malheiros Coutinho-Camillo, Fabio de Abreu Alves, Luiz Paulo Kowalski, Katharina Jähn-Rickert, Björn Busse, Gustavo Davi Rabelo
The objective of this study was to assess the remodeling-associated gene expression in the mandible of patients diagnosed with oral squamous cell carcinoma (OSCC), investigating the cortical microarchitecture, and their influence on disease-free survival (DFS) and overall survival (OS) rates. A total of twenty-four patients who underwent mandibulectomy for OSCC treatment had two bone fragments harvested from the mandible for gene expression (RANK, RANKL, OPG, and SOST), and microarchitecture analysis, including bone volume, surface, mineral density, degree of anisotropy, and fractal dimension...
2023: Brazilian Oral Research