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https://www.readbyqxmd.com/read/29071436/measurement-and-scan-reproducibility-of-parameters-of-intravoxel-incoherent-motion-in-renal-tumor-and-normal-renal-parenchyma-a-preliminary-research-at-3-0%C3%A2-t-mr
#1
Jingjing Pan, Hongtao Zhang, Fengyuan Man, Yanguang Shen, Yingwei Wang, Yan Zhong, Lu Ma, Haiyi Wang, Huiyi Ye
PURPOSE: To prospectively estimate measurement and scan reproducibility of parameters of intravoxel incoherent motion (IVIM) in renal tumors, normal renal cortex, and medulla. METHODS: Twenty-four consecutive patients (twelve males and twelve females; median age 56.7 years, range 32-71 years) with 25 renal tumors (20 renal cell carcinomas, one urothelium carcinoma, three angiomyolipomas, and one oncocytoma) were examined twice using IVIM1 and IVIM2 with 9 and 16 b values, respectively, at 3...
October 25, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28994198/the-incidence-of-thyroid-cartilage-invasion-in-early-stage-laryngeal-carcinoma-our-experience-on-sixty-two-patients
#2
LETTER
H M Yener, M Yilmaz, A B Karaaltın, H C Inan, F Turgut, E D Gözen, N Comunoglu, E Karaman
No abstract text is available yet for this article.
October 10, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28976334/super-scan-caused-by-parathyroid-carcinoma-observed-both-in-18-f-fdg-pet-ct-scan-and-tc-99m-mdp-bone-scintigraphy
#3
İsa Burak Güney, Semra Paydaş, Hüseyin Tuğsan Ballı
Super scan is a well-known finding described in skeletal scintigraphy characterized by uniform symmetrically increased radiopharmaceutical uptake by bones and consequently diminished renal parenchymal activity. Sy et al. hypothesized that the faint visualization of renal cortex in bone scintigraphy might be the result of increased uptake of radiopharmaceutical by pathologic bones and reduced phosphate excretion. The super scan on (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) has been observed in various conditions such as prostate cancer, lung cancer, renal adenocarcinoma, gastric cancer and primitive neuroectodermal tumor of the kidney...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28975890/identification-and-validation-of-novel-prognostic-markers-in-renal-cell-carcinoma
#4
Maj Rabjerg
Kidney cancer (Renal Cell Carcinoma (RCC)) is one of the most deadly malignancies due to frequent late diagnosis and poor treatment options. Histologically, RCC embraces a wide variety of different subtypes with the clear cell variant (ccRCC) being the most common, accounting for 75-90% of all RCCs. At present, the surveillance protocols for follow-up of RCC patients after radical nephrectomy are based on the American Joint Committee on Cancers (AJCC) pathological tumor-node-metastasis (TNM) classification system...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28943972/small-non-coding-rna-abundance-in-adrenocortical-carcinoma-a-footprint-of-a-rare-cancer
#5
Srinivas V Koduru, Ashley N Leberfinger, Dino J Ravnic
BACKGROUND: Adrenocortical carcinoma (ACC) is a relatively rare, but aggressive type of cancer, which affects both children and adults. OBJECTIVE: Small non-coding RNAs (sncRNAs) play important roles and may serve as biomarkers for disease diagnosis, prognosis and treatment. METHODS: In our study, we sought to identify sncRNAs associated with malignant adrenal tumors. We obtained publicly available, small RNA sequencing data derived from 45 ACC and 30 benign tumors arising from the cortex of the adrenal gland, adrenocortical adenomas (ACA), and compared their sncRNA expression profiles...
2017: Journal of Genomics
https://www.readbyqxmd.com/read/28877063/sentinel-lymph-nodes-in-classic-invasive-lobular-carcinoma-of-the-breast-cytokeratin-immunostain-ensures-detection-and-precise-determination-of-extent-of-involvement
#6
Ami Patel, Timothy D'Alfonso, Esther Cheng, Syed A Hoda
The assessment of sentinel lymph nodes (SLN) on hematoxylin and eosin (H&E)-stained sections in cases of classic type of invasive lobular carcinoma (cILC) is considered unreliable, particularly in cases with minimal involvement, that is by either isolated tumor cells (pN0i+) or micrometastases (pN1mi). Although the impact of minimal SLN involvement has been shown to be insignificant in most clinical trials (even though cILC was either under-represented or not separated in the respective cohorts), the results of MIRROR trial did emphasize the need for additional therapy in cases with minimally involved SLN to ensure improved disease-free survival...
November 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28872547/fdg-pet-ct-in-2-cases-of-renal-metastasis-from-esophageal-squamous-cell-carcinoma
#7
Qian Zhao, Aisheng Dong, Bo Yang, Yang Wang, Changjing Zuo
Clinically, renal metastasis from esophageal squamous cell carcinoma is uncommon. We present 2 cases of renal metastasis from esophageal squamous cell carcinoma with enhanced CT and FDG PET/CT findings. In the first case, right kidney and right renal hilum were the only known metastatic sites. In the second case, bilateral kidneys were the only known metastatic sites. All the renal metastatic tumors appeared as hypovascular and hypoattenuating masses involving both the renal cortex and medulla on enhanced CT and intense FDG uptake on FDG PET/CT...
September 1, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28757600/relative-computed-tomography-ct-enhancement-value-for-the-assessment-of-microvascular-architecture-in-renal-cell-carcinoma
#8
Ai-Mei Ouyang, Zhao-Long Wei, Xin-You Su, Kun Li, Dong Zhao, De-Xin Yu, Xiang-Xing Ma
BACKGROUND To investigate the correlation between the relative computed tomography (CT) enhancement value and the microvascular architecture in different pathologic subtypes of renal cell carcinoma (RCC). MATERIAL AND METHODS This retrospective study included 55 patients with pathologically confirmed RCC. Immunohistochemistry for CD34 was performed for all surgical specimens. Microvascular architecture parameters (density, area, diameter, and perimeter) for the microvessels and the microvessels with lumen were determined...
July 31, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28713756/dental-invasion-by-adenoid-cystic-carcinoma-of-the-oral-cavity
#9
Marco Guzzo, Pasquale Quattrone, Roberto Bianchi, Sarah Colombo
Cancer progression through the mandible bone is still questioned. Once the tumor has eroded the cortex, it can extend vertically and laterally. It usually spreads in the medullary spaces and finally affects the alveolar nerve. The presence of the teeth has been considered as a relative barrier to cancer infiltration until now. Herein, we report an uncommon case of dental root invasion by adenoid cystic carcinoma of the floor of the mouth.
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28694749/variability-of-antioxidant-and-biological-activities-of-rhus-tripartitum-related-to-phenolic-compounds
#10
Hanène Ben Miled, Mariem Saada, Ines Jallali, Zaineb Ben Barka, Mounira Tlili, Hichem Alimi, Mohsen Sakly, Khémais Ben Rhouma, Manef Abderrabba, Hafedh Abdelmelek, Olfa Tebourbi, Riadh Ksouri
Rhus species are known in traditional medicine for their therapeutic virtue and their extracts showed numerous important properties including antimalarial, antimicrobial, antiviral, and hypoglycemic and anticonvulsant activities. Rhus tripartitum (Ucria) is a medicinal plant widely used in Tunisia folk medicine against chronic diarrhea and gastric ulcer. This study was designed to examine in vitro and ex vivo antioxidant, anti-inflammatory and anticancer activities of four extracts of Rhus tripartitum root cortex with increasing solvent polarity (hexane, dichloromethane, methanol and water)...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28693225/dynamic-mri-follow-up-of-radiation-encephalopathy-in-the-temporal-lobe-following-nasopharyngeal-carcinoma-radiotherapy
#11
Xiaofeng Zhou, Xiaofang Liao, Xiaoqiu Ren, Kewei Xiang, Qiongge Hu, Minming Zhang, Huijuan He, Li Shen, Qichun Wei
The natural course of radiation encephalopathy following nasopharyngeal carcinoma (NPC) radiotherapy remains poorly understood. The present study aimed to investigate the magnetic resonance imaging (MRI) characteristics and evolution of radiation encephalopathy. A series of 162 follow-up MRI examinations from 68 NPC patients with radiation encephalopathy in the temporal lobes were analyzed retrospectively. Each component of radiation encephalopathy was defined as follows: i) contrast enhanced lesions were enhanced lesions on contrast enhanced T1-weighted images (T1WI); ii) white matter lesions were lesions of homogeneous hyperintensity on T2-weighted images (T2WI) and hypointensity on T1WI; iii) cysts were round or oval well-defined lesions of hyperintensity on T2WI; iv) hemosiderin deposition were nodular or annular hypointense lesions with lower hypointense than normal white matter on both T1WI and T2WI; v) gray matter lesions were defined as disruption or erosion of hyperintensity in the cortex on T2WI...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28672049/diagnostic-and-prognostic-role-of-sf1-igf2-ki67-p53-adiponectin-and-leptin-receptors-in-human-adrenal-cortical-tumors
#12
Anna Babińska, Rafał Pęksa, Piotr Wiśniewski, Renata Świątkowska-Stodulska, Krzysztof Sworczak
BACKGROUND: The authors have examined the immunohistochemical expression of several proteins and their relationship with adrenal cortical carcinoma (ACC) diagnosis and progression. MATERIALS AND METHODS: A total of 83 patients with benign and malignant adrenal cortex tumors operated on in a single center were included in the study. Expression of the following proteins was examined: steroidogenic factor 1 (SF1), insulin growth factor 2 (IGF2), Ki67, p53, as well as adiponectin (Adipo R1, Adipo R2), and leptin (Ob-R) receptors...
September 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28669081/distribution-of-vascular-patterns-in-different-subtypes-of-renal-cell-carcinoma-a-morphometric-study-in-two-distinct-types-of-blood-vessels
#13
Amparo Ruiz-Saurí, V García-Bustos, E Granero, S Cuesta, M A Sales, V Marcos, A Llombart-Bosch
To analyze the presence of mature and immature vessels as a prognostic factor in patients with renal cell carcinoma and propose a classification of renal cancer tumor blood vessels according to morphometric parameters. Tissue samples were obtained from 121 renal cell carcinoma patients who underwent radical nephrectomy. Staining with CD31 and CD34 was used to differentiate between immature (CD31+) and mature (CD34+) blood vessels. We quantified the microvascular density, microvascular area and different morphometric parameters: maximum diameter, minimum diameter, major axis, minor axis, perimeter, radius ratio and roundness...
July 1, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28647863/evaluation-of-cortical-mandibular-bone-in-patients-with-oral-squamous-cell-carcinoma
#14
Gustavo Davi Rabelo, Claudia Coutinho-Camillo, Luiz Paulo Kowalski, Nathalie Portero-Muzy, Jean-Paul Roux, Pascale Chavassieux, Fabio Abreu Alves
OBJECTIVES: The aim of the study was to evaluate the mandible cortical bone changes in patients with oral squamous cell carcinoma (OSCC). PATIENTS AND METHODS: Twenty patients who underwent some mandibular bone removal as part of the treatment of OSCC had bone samples collected in two parts: in the proximity of the tumor (BPT) and in the surgical margin (BEP). Cortical microarchitecture was analyzed trough micro-computed tomography, together with texture analysis, followed by microcrack evaluation in histological sections and gene expression of RANK, RANKL, OPG, and sclerostin by quantitative polymerase chain reaction...
June 24, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28630395/cerebral-infarction-by-paradoxical-gas-embolism-during-laparoscopic-liver-resection-with-injury-of-the-hepatic-vessels-in-a-patient-without-a-right-to-left-systemic-shunt
#15
Toshiyasu Kawahara, Masahiro Hagiwara, Hiroyuki Takahashi, Mariko Tanaka, Koji Imai, Jun Sawada, Takayuki Kunisawa, Hiroyuki Furukawa
BACKGROUND Carbon dioxide (CO2) is believed to be the safest gas for laparoscopic surgery, which is a standard procedure. We experienced severe cerebral infarction caused by paradoxical CO2 embolism during laparoscopic liver resection with injury of the hepatic vessels despite the absence of a right-to-left systemic shunt. CASE REPORT A 60-year-old man was diagnosed with hepatocellular carcinoma in the right hepatic lobe secondary to alcoholic liver disease. We planned the laparoscopy-assisted liver resection...
June 20, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28605527/effect-of-transcranial-direct-current-stimulation-of-the-motor-cortex-on-visceral-pain-in-patients-with-hepatocellular-carcinoma
#16
Nagwa Mostafa Ibrahim, Khaled Mohamed Abdelhameed, Shereen Mamdouh Mohamed Kamal, Eman Mohamed Hussein Khedr, Hassan Ibrahim Mohamed Kotb
Objective. : Hepatocellular carcinoma (HCC) is frequently associated with visceral pain. Transcranial direct current stimulation (tDCS) has been proven to reduce chronic pain; however, its effectiveness in malignant visceral pain is unknown. This study aimed to investigate the effects of tDCS in patients with visceral pain due to HCC. Design. : This is a randomized, sham-controlled, double-blind, prospective study. Forty patients with visceral pain due to HCC were enrolled and randomly assigned into two groups: a real and a sham group; tDCS was applied over the primary motor area (M1) for 10 consecutive days (2 mA, 30 minutes)...
June 12, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28600877/stepwise-algorithm-using-computed-tomography-and-magnetic-resonance-imaging-for-diagnosis-of-fat-poor-angiomyolipoma-in-small-renal-masses-development-and-external-validation
#17
Hajime Tanaka, Yasuhisa Fujii, Hiroshi Tanaka, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Sho Uehara, Noboru Numao, Takeshi Yuasa, Shinya Yamamoto, Hitoshi Masuda, Junji Yonese, Kazunori Kihara
OBJECTIVES: To develop a stepwise diagnostic algorithm for fat-poor angiomyolipoma in small renal masses. METHODS: Two cohorts of small renal masses <4 cm without an apparent fat component that was pathologically diagnosed were included: 153 cases (18 fat-poor angiomyolipomas/135 renal cell carcinomas) for model development and 71 cases (seven fat-poor angiomyolipomas/59 renal cell carcinomas/5 oncocytomas) for validation. Dynamic contrast-enhanced computed tomography, magnetic resonance imaging and clinical findings were analyzed...
July 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28567326/renal-myxoma-an-incidental-finding
#18
Parth Thakker, Tam Ramsey, Fernando Navarro
Myxomas are mesenchymal tumors commonly found in the heart and skin. Renal myxomas are rare, having only been documented 14 times. Our case is a 55-year-old woman who presented to our clinic after a right renal mass was incidentally found on CT. Evaluation with MRI showed a mass that appeared to arise from the supero-medial cortex of the right kidney. As the imaging was concerning for renal cell carcinoma, the patient underwent a partial nephrectomy. Microscopic examination showed a well-circumscribed mass with polygonal to spindle-shaped cells in a granular eosinophilic cytoplasm...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28566623/moutan-cortex-protects-hepatocytes-against-oxidative-injury-through-amp-activated-protein-kinase-pathway
#19
Mi Hee Jang, Kwang-Youn Kim, Phil Hyun Song, Su Youn Baek, Hye Lim Seo, Eun Hye Lee, Suel-Gi Lee, Kwang Il Park, Soon-Cheol Ahn, Sang Chan Kim, Young Woo Kim
Moutan Cortex, the root bark of Paeonia suffruticosa ANDREWS in Ranunculaceae, has widely demonstrated analgesic, anti-spasmodic, and anti-inflammatory effects in various cancer and immune cell lines. Oxidative stress is associated with development of several diseases, including liver disease. We prepared the water extract of Moutan Cortex (MCE) to investigate the cytoprotective activities and its mechanism. MCE protected hepatocytes from arachidonic acid (AA)+iron induced oxidative stress, as indicated by reactive oxygen species (ROS) production and cell viability analysis...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28504543/clear-cell-renal-cell-carcinoma-identifying-the-loss-of-the-y-chromosome-on-multiphasic-mdct
#20
Jonathan R Young, Heidi Coy, Michael Douek, Pechin Lo, James Sayre, Allan J Pantuck, Steven S Raman
OBJECTIVE: The objective of our study was to investigate whether multiphasic MDCT enhancement can help identify clear cell renal cell carcinomas (RCCs) with the loss of the Y chromosome. MATERIALS AND METHODS: We derived a cohort of 43 clear cell RCCs in men who underwent preoperative four-phase renal mass MDCT from October 2000 to August 2013. Each lesion was segmented in its entirety on axial images. A computer-assisted detection algorithm selected a 0.5-cm-diameter region of maximal attenuation within each lesion in each phase...
August 2017: AJR. American Journal of Roentgenology
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