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https://www.readbyqxmd.com/read/28823136/identification-of-polymorphisms-in-mitf-and-dct-genes-and-their-associations-with-plumage-colors-in-asian-duck-breeds
#1
Hasina Sultana, Dongwon Seo, Nu-Ri Choi, Md Shamsul Alam Bhuiyan, Seung Hwan Lee, Kang Nyeong Heo, Jun Heon Lee
Objective: The aim of this study was to investigate the effect of single nucleotide polymorphisms (SNPs) of the MITF and DCT genes on plumage coloration in Asian native duck breeds. MITF encodes a protein for microphthalmia-associated transcription factor, which regulates the development and function of melanocytes for pigmentation of skin, hair, and eyes. Among the tyrosinase-related family genes, dopachrome tautomerase (DCT) is a pigment cell-specific gene that plays important roles in the melanin synthesis pathway and the expression of skin, feather, and retina color...
August 16, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28819321/sh3bp4-a-novel-pigmentation-gene-is-inversely-regulated-by-mir-125b-and-mitf
#2
Kyu-Han Kim, Tae Ryong Lee, Eun-Gyung Cho
Our previous work has identified miR-125b as a negative regulator of melanogenesis. However, the specific melanogenesis-related genes targeted by this miRNA had not been identified. In this study, we established a screening strategy involving three consecutive analytical approaches-analysis of target genes of miR-125b, expression correlation analysis between each target gene and representative pigmentary genes, and functional analysis of candidate genes related to melanogenesis-to discover melanogenesis-related genes targeted by miR-125b...
August 18, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28794318/dysregulated-expression-of-mitf-in-subsets-of-hepatocellular-carcinoma-and-cholangiocarcinoma
#3
Nattakarn Nooron, Koji Ohba, Kazuhisa Takeda, Shigeki Shibahara, Anchalee Chiabchalard
Cholangiocarcinoma represents the second most common primary liver tumor after hepatocellular carcinoma. Mahanine, a carbazole alkaloid derived from Murraya koenigii (Linn.) Spreng, has been used as folk medicine in Thailand, where the liver fluke-associated cholangiocarcinoma is common. The expression of microphthalmia-associated transcription factor (MITF) is maintained at immunohistochemically undetectable levels in hepatocytes and cholangiocytes. To explore the regulation of MITF expression in the liver, we immunohistochemically analyzed the MITF expression using hepatocellular carcinoma and cholangiocarcinoma specimens of the human liver cancer tissue array...
August 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28793915/the-functional-property-of-royal-jelly-10-hydroxy-2-decenoic-acid-as-a-melanogenesis-inhibitor
#4
Chi-Chung Peng, Hui-Tzu Sun, I-Ping Lin, Ping-Chung Kuo, Jen-Chieh Li
BACKGROUND: It has been reported that royal jelly would reduce melanin synthesis and inhibit the expression of melanogensis related proteins and genes. In this study, we evaluate the anti-melanogenic and depigmenting activity of 10-hydroxy-2-decenoic acid (10-HDA) from royal jelly of Apis mellifera. METHODS: In this study, we assesses the 10-HDA whitening activity in comparison with the changes in the intracellular tyrosinase activity, melanin content and melanin production related protein levles in B16F1 melanoma cells after treating with 10-HDA...
August 9, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28777840/-study-of-gene-mutation-and-pathogenetic-mechanism-for-a-family-with-waardenburg-syndrome
#5
Hongsheng Chen, Xinbin Liao, Yalan Liu, Chufeng He, Hua Zhang, Lu Jiang, Yong Feng, Lingyun Mei
OBJECTIVE: To explore the pathogenetic mechanism of a family affected with Waardenburg syndrome. METHODS: Clinical data of the family was collected. Potential mutation of the MITF, SOX10 and SNAI2 genes were screened. Plasmids for wild type (WT) and mutant MITF proteins were constructed to determine their exogenous expression and subcellular distribution by Western blotting and immunofluorescence assay, respectively. RESULTS: A heterozygous c...
August 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28777813/the-integrated-analysis-of-rna-seq-and-microrna-seq-depicts-mirna-mrna-networks-involved-in-japanese-flounder-paralichthys-olivaceus-albinism
#6
Na Wang, Ruoqing Wang, Renkai Wang, Yongsheng Tian, Changwei Shao, Xiaodong Jia, Songlin Chen
Albinism, a phenomenon characterized by pigmentation deficiency on the ocular side of Japanese flounder (Paralichthys olivaceus), has caused significant damage. Limited mRNA and microRNA (miRNA) information is available on fish pigmentation deficiency. In this study, a high-throughput sequencing strategy was employed to identify the mRNA and miRNAs involved in P. olivaceus albinism. Based on P. olivaceus genome, RNA-seq identified 21,787 know genes and 711 new genes by transcripts assembly. Of those, 235 genes exhibited significantly different expression pattern (fold change ≥2 or ≤0...
2017: PloS One
https://www.readbyqxmd.com/read/28772207/bone-marrow-mesenchymal-stromal-cell-msc-gene-profiling-in-chronic-myeloid-leukemia-cml-patients-at-diagnosis-and-in-deep-molecular-response-induced-by-tyrosine-kinase-inhibitors-tkis
#7
Djamel Aggoune, Nathalie Sorel, Marie-Laure Bonnet, Jean-Michel Goujon, Karin Tarte, Olivier Hérault, Jorge Domenech, Delphine Réa, Laurence Legros, Hyacinthe Johnson-Ansa, Philippe Rousselot, Emilie Cayssials, Agnès Guerci-Bresler, Annelise Bennaceur-Griscelli, Jean-Claude Chomel, Ali G Turhan
Although it has been well-demonstrated that bone marrow mesenchymal stromal cells (MSCs) from CML patients do not belong to the Ph1-positive clone, there is growing evidence that they could play a role in the leukemogenesis process or the protection of leukemic stem cells from the effects of tyrosine kinase inhibitors (TKIs). The aim of the present study was to identify genes differentially expressed in MSCs isolated from CML patients at diagnosis (CML-MSCs) as compared to MSCs from healthy controls. Using a custom gene-profiling assay, we identified six genes over-expressed in CML-MSCs (BMP1, FOXO3, MET, MITF, NANOG, PDPN), with the two highest levels being documented for PDPN (PODOPLANIN) and NANOG...
July 26, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28765043/feruloylserotonin-inhibits-hydrogen-peroxide-induced-melanogenesis-and-apoptosis-in-b16f10-and-sk-mel-2-melanoma-cells
#8
Hyejoung Cho, Okjoon Kim, Younghee Lee, Li-Jung Kang, Cam Ngoc Nguyen, Atsushi Ishihara, Hye-Eun Kim
Feruloylserotonin (FS) is a major bioactive component of safflower seeds, with documented strong antibacterial, anti-inflammatory, and free radical scavenging activities. Reactive oxygen species (ROS) can strongly induce melanogenesis and cell apoptosis. The present study aimed to investigate the ability of FS in preventing hydrogen peroxide (H2O2)-induced melanogenesis and cell apoptosis. Melanogenesis and apoptotic cell death were induced by transient exposure to H2O2 in B16F10 and SK-Mel-2 melanoma cells...
July 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28759004/a-common-intronic-variant-of-parp1-confers-melanoma-risk-and-mediates-melanocyte-growth-via-regulation-of-mitf
#9
Jiyeon Choi, Mai Xu, Matthew M Makowski, Tongwu Zhang, Matthew H Law, Michael A Kovacs, Anton Granzhan, Wendy J Kim, Hemang Parikh, Michael Gartside, Jeffrey M Trent, Marie-Paule Teulade-Fichou, Mark M Iles, Julia A Newton-Bishop, D Timothy Bishop, Stuart MacGregor, Nicholas K Hayward, Michiel Vermeulen, Kevin M Brown
Previous genome-wide association studies have identified a melanoma-associated locus at 1q42.1 that encompasses a ∼100-kb region spanning the PARP1 gene. Expression quantitative trait locus (eQTL) analysis in multiple cell types of the melanocytic lineage consistently demonstrated that the 1q42.1 melanoma risk allele (rs3219090[G]) is correlated with higher PARP1 levels. In silico fine-mapping and functional validation identified a common intronic indel, rs144361550 (-/GGGCCC; r(2) = 0.947 with rs3219090), as displaying allele-specific transcriptional activity...
July 31, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28754858/melphalan-modifies-the-bone-microenvironment-by-enhancing-osteoclast-formation
#10
Ryan C Chai, Michelle M McDonald, Rachael L Terry, Nataša Kovačić, Jenny M Down, Jessica A Pettitt, Sindhu T Mohanty, Shruti Shah, Gholamreza Haffari, Jiake Xu, Matthew T Gillespie, Michael J Rogers, John T Price, Peter I Croucher, Julian M W Quinn
Melphalan is a cytotoxic chemotherapy used to treat patients with multiple myeloma (MM). Bone resorption by osteoclasts, by remodeling the bone surface, can reactivate dormant MM cells held in the endosteal niche to promote tumor development. Dormant MM cells can be reactivated after melphalan treatment; however, it is unclear whether melphalan treatment increases osteoclast formation to modify the endosteal niche.Melphalan treatment of mice for 14 days decreased bone volume and the endosteal bone surface, and this was associated with increases in osteoclast numbers...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28753056/gamma-irradiated-luteolin-inhibits-3-isobutyl-1-methylxanthine-induced-melanogenesis-through-the-regulation-of-creb-mitf-pi3k-akt-and-erk-pathways-in-b16bl6-melanoma-cells
#11
Eui-Baek Byun, Ha-Yeon Song, Sajid Mushtaq, Hye-Min Kim, Jung Ae Kang, Mi-So Yang, Nak-Yun Sung, Beom-Su Jang, Eui-Hong Byun
Luteolin was gamma irradiated at doses of 0, 15, 30, 50, 70, and 100 kGy. We observed that the luteolin peak decreased simultaneously with the appearance of new radiolytic peaks, using high-performance liquid chromatography (HPLC). The highest new radiolytic peak (GLM) of radiolytic product in gamma-irradiated luteolin was observed at a dose of 70 kGy, and the GLM was identified by nuclear magnetic resonance and high-performance-liquid-chromatography-quadrupole-time-of-flight (HPLC-Q-TOF) mass spectrometry...
August 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28738256/p53-and-mitf-bcl-2-identified-as-key-pathways-in-the-acquired-resistance-of-nras-mutant-melanoma-to-mek-inhibition
#12
Ahmad Najem, Mohammad Krayem, François Salès, Nader Hussein, Bassam Badran, Caroline Robert, Ahmad Awada, Fabrice Journe, Ghanem E Ghanem
Activating mutations in Neuroblastoma RAS viral oncogene homolog (NRAS) are found in 15-30% of melanomas and are associated with a poor prognosis. Although MAP kinase kinase (MEK) inhibitors used as single agents showed a limited clinical benefit in patients with NRAS-mutant melanoma due to their rather cytostatic effect and high toxicity, their combination with other inhibitors of pathways known to cooperate with MEK inhibition may maximise their antitumour activity. Similarly, in a context where p53 is largely inactivated in melanoma, hyperexpression of Microphthalmia associated transcription factor (MITF) and its downstream anti-apoptotic targets may be the cause of the restraint cytotoxic effects of MEK inhibitors...
July 21, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28734968/identification-of-an-mitf-gene-and-its-polymorphisms-associated-with-the-vibrio-resistance-trait-in-the-clam-meretrix-petechialis
#13
Shujing Zhang, Xin Yue, Fengjuan Jiang, Hongxia Wang, Baozhong Liu
Microphthalmia-associated transcription factor (MITF) regulates the transcription of its target genes by binding to their promoters. In this study, an MITF gene, MpMITF was identified in the clam Meretrix petechialis. The full-length cDNA of MpMITF is 3564 bp with an ORF of 1365 bp. The deduced amino acid sequence consists of a conserved functional structure of bHLH-LZ, which could bind with E-box. The mRNA and protein expression levels of MpMITF were significantly up-regulated 6 h post-Vibrio injection. The mRNA expression of MpMITF increased on day 2 and peaked on day 10 post-Vibrio immersion...
July 19, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28701866/inhibitory-effects-of-ginsenosides-on-basic-fibroblast-growth-factor-induced-melanocyte-proliferation
#14
Ji Eun Lee, Jong Il Park, Cheol Hwan Myung, Jae Sung Hwang
BACKGROUND: UV-B-exposed keratinocytes secrete various paracrine factors. Among these factors, basic fibroblast growth factor (bFGF) stimulates the proliferation of melanocytes. Ginsenosides, the major active compounds of ginseng, are known to have broad pharmacological effects. In this study, we examined the antiproliferative effects of ginsenosides on bFGF-induced melanocyte proliferation. METHODS: We investigated the inhibitory effects of Korean Red Ginseng and ginsenosides from Panax ginseng on bFGF-induced proliferation of melan-a melanocytes...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28698966/two-skin-cell-lines-from-wild-type-and-albino-japanese-flounder-paralichthys-olivaceus-establishment-characterization-virus-susceptibility-efficient-transfection-and-application-to-albinism-study
#15
Ruoqing Wang, Nianwei Zhang, Renkai Wang, Shengpeng Wang, Na Wang
In order to provide an applicable cell platform to study fish pathology and skin pigmentation, two cell lines derived from skin tissues of wild-type and albino Japanese flounder were established and named JFSK_wt and JFSK_alb, respectively. These two cell lines were cultured for 45 passages within approximately 300 days. JFSK_wt and JFSK_alb cells were maintained in Dulbecco's Modified Eagle's Medium and Ham's F-12 Nutrient Mixture (DMEM/F12) supplemented with antibiotics, fetal bovine serum (FBS), 2-mercaptoethanol (2-Me), N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES), and basic fibroblast growth factor (bFGF)...
July 11, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28698805/microrna-26a-inhibits-the-growth-and-invasiveness-of-malignant-melanoma-and-directly-targets-on-mitf-gene
#16
Hui Qian, Chen Yang, Yixin Yang
Metastatic melanoma is the most aggressive form of skin cancer and is refractory to therapy. MicroRNAs have been recently discovered as novel molecules that provide therapeutic benefits against melanoma. This work aims to examine the effects of miR-26a and let-7a on the growth and invasiveness of malignant melanoma in vitro and in vivo. In addition, we elucidate the mechanism of action by identifying the target gene of miR-26a. Both miR-26a and let-7a inhibited proliferation and invasiveness and halted the cell cycle at the G1/G0 phase in SKMEL-28 and WM1552C malignant melanoma cell lines...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28697505/the-importance-of-11%C3%AE-oh-15-oxo-and-16-en-moieties-of-11%C3%AE-hydroxy-15-oxo-kaur-16-en-19-oic-acid-in-its-inhibitory-activity-on-melanogenesis
#17
Azusa Kuroi, Koji Sugimura, Ayako Kumagai, Arihiro Kohara, Yasuo Nagaoka, Hidehisa Kawahara, Minori Yamahara, Nobuo Kawahara, Hiroshi Takemori, Hiroyuki Fuchino
Cosmetic industries have an interest in exploring and developing materials that have the potential to regulate melanin synthesis in human skin. Although melanin protects the skin from ultraviolet irradiation, excess melanin can be undesirable, particularly on the face where spots or freckles are associated with an appearance of aging. In this study, we found that ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid (11α-OH KA) in Pteris dispar Kunze strongly inhibited melanin synthesis by suppressing tyrosinase gene expression...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28695326/anti-melanogenic-effect-of-gomisin-n-from-schisandra-chinensis-turcz-baillon-schisandraceae-in-melanoma-cells
#18
JungNo Lee, Hwa Sun Ryu, Jae-Moon Kim, Tae-Hwa Jung, Sung-Min Park, Yong-Moon Lee
Overproduction and accumulation of melanin in the skin can lead to pigmentation disorders, such as freckles and melasma. Many researchers are studying the regulation of melanogenesis in the skin with the aim of developing whitening cosmetics. In this study, bioactivity-guided separation of the hexane fraction of Schisandra chinensis (Turcz.) Baillon extract yielded five major compounds, β-chamigrenal, α-ylangenol, gomisin N, gomisin A, and schisandrin. The structures were identified by using (1)H-NMR and (13)C-NMR spectroscopy and comparing the spectral data with published data...
July 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28692464/melanocytes-pattern-in-the-normal-nail-with-special-reference-to-nail-bed-melanocytes
#19
Christophe Perrin, Jean-F Michiels, Julien Boyer, Damien Ambrosetti
Previous studies of the density of melanocytes in the normal nail bed have had conflicting results. This is unfortunate because knowing the normal values might help the difficult distinction between a benign subungual melanotic macule and an early melanoma in situ. Five specimens of normal nail unit were analyzed. On hematoxylin and eosin-stained sections the melanocytes were undetectable. We defined the melanocyte count (MC) as the number of melanocytes per 1-mm stretch of nail epithelium. The mean MC for nail matrix was 6...
June 19, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28690485/a-novel-pathogenic-variant-in-the-mitf-gene-segregating-with-a-unique-spectrum-of-ocular-findings-in-an-extended-iranian-waardenburg-syndrome-kindred
#20
Nazanin Jalilian, Mohammad A Tabatabaiefar, Tayyeb Bahrami, Golaleh Karbasi, Mohammad H Bahramian, Abdolrahman Salimpoor, Mohammad R Noori-Daloii
Waardenburg syndrome (WS) is a rare genetic disorder characterized by abnormal pigmentation of the hair, skin, and iris as well as sensorineural hearing loss. WS is subdivided into 4 major types (WS1-4), where WS2 is characterized by the absence of dystopia canthorum. This study was launched to investigate clinical and molecular characteristics of WS in an extended Iranian WS2 family. A comprehensive clinical investigation was performed. Peripheral blood samples were collected and genomic DNA was extracted...
June 2017: Molecular Syndromology
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