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Caregiver burden parkinson's dementia

R A Lawson, A J Yarnall, F Johnston, G W Duncan, T K Khoo, D Collerton, J P Taylor, D J Burn
BACKGROUND: The quality of life (QoL) of informal caregivers of people with Parkinson's disease (PD) (PwP) can be affected by the caring role. Because of cognitive symptoms and diminished activities of daily living, in addition to the management of motor symptoms, carers of PwP and cognitive impairment may experience increased levels of burden and poorer QoL compared with carers of PwP without cognitive impairment. This study aimed to investigate the impact of cognitive impairment in PD upon QoL of carers...
December 7, 2016: International Journal of Geriatric Psychiatry
Sheung-Tak Cheng, Helene H Fung, Wai Chi Chan, Linda C W Lam
OBJECTIVE: To examine the effects of a benefit-finding intervention, the key feature being the use of gain-focused reappraisal strategies to find positive meanings and benefits in caring for someone with dementia. METHODS: In a cluster-randomized, double-blind, controlled trial conducted in social centers and clinics, 129 caregivers aged 18 + and without cognitive impairment, providing at least 14 care hours per week to a relative with mild-to-moderate Alzheimer disease, and scoring ≥ 3 on the Hamilton Depression Rating Scale were studied...
September 2016: American Journal of Geriatric Psychiatry
Pai-Yi Chiu, Chun-Tang Tsai, Ping-Kun Chen, Whe-Jen Chen, Te-Jen Lai
BACKGROUND AND PURPOSE: Previous studies on the clinical and pathological manifestations of Parkinson's disease dementia (PDD) have reported findings more similar to dementia with Lewy bodies (DLB) than to Alzheimer's disease (AD). The aim of this study was to investigate the neuropsychiatric symptoms of PDD compared to DLB and AD. METHODS: We conducted a retrospective case-control study on 125 newly diagnosed consecutive PDD patients and age- and dementia stage-matched controls with either DLB (N = 250) or AD (N = 500) who visited the same hospital over the same period...
2016: PloS One
Samantha K Holden, Wallace E Jones, Keith A Baker, Isabel M Boersma, Benzi M Kluger
BACKGROUND: Parkinson's disease dementia (PDD) is a major cause of morbidity and mortality in Parkinson's disease (PD), which severely affects patient functioning and quality of life and increases the risk for nursing home admission. Unfortunately, current treatment options for PDD are limited and have only marginal therapeutic effects. As novel treatments are developed, there will be a need to assess their efficacy in well-designed randomized controlled trials. However, there is no consensus on the optimal outcome measures for use in PDD clinical trials...
January 2016: Movement Disorders Clinical Practice
Diego Santos-García, Pablo Mir, Esther Cubo, Lydia Vela, Mari Cruz Rodríguez-Oroz, Maria José Martí, José Matías Arbelo, Jon Infante, Jaime Kulisevsky, Pablo Martínez-Martín
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder causing motor and non-motor symptoms that can affect independence, social adjustment and the quality of life (QoL) of both patients and caregivers. Studies designed to find diagnostic and/or progression biomarkers of PD are needed. We describe here the study protocol of COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015), an integral PD project based on four aspects/concepts: 1) PD as a global disease (motor and non-motor symptoms); 2) QoL and caregiver issues; 3) Biomarkers; 4) Disease progression...
2016: BMC Neurology
Josie-Anne Bertrand, Anthony R McIntosh, Ronald B Postuma, Natasha Kovacevic, Véronique Latreille, Michel Panisset, Sylvain Chouinard, Jean-François Gagnon
Dementia affects a high proportion of Parkinson's disease (PD) patients and poses a burden on caregivers and healthcare services. Electroencephalography (EEG) is a common nonevasive and nonexpensive technique that can easily be used in clinical settings to identify brain functional abnormalities. Only few studies had identified EEG abnormalities that can predict PD patients at higher risk for dementia. Brain connectivity EEG measures, such as multiscale entropy (MSE) and phase-locking value (PLV) analyses, may be more informative and sensitive to brain alterations leading to dementia than previously used methods...
April 2016: Brain Connectivity
Jan Domaradzki
Caring for a person with chronic disease often rests on the patient's family. Nevertheless, most studies on the needs, quality of life and caregiver burden focus on different types of dementia, including Alzheimer's and Parkinson's disease, stroke, cancer or mental illnesses. Less attention has been paid to informal caregivers of patients with Huntington's disease (HD). Meanwhile, psychosocial implications of HD are much more serious and wide-ranging. Thus, this paper aims to review the literature on the costs of caring for a person with HD (pHD)...
2015: Psychiatria Polska
Jaya Sanyal, Soumi Das, Epsita Ghosh, T K Banerjee, L V K S Bhaskar, Vadlamudi Raghavendra Rao
Aim was to analyze predictors of burden among primary caregivers (CGs) of Indian Parkinson's disease (PD) patients. 150 PD patients were administered using Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr Scale (H&Y), Montgomery Asberg Depression Rating Score (MADRS) and Mini Mental State Examination (MMSE) in this cross-sectional evaluation study. CG burden was assessed by Caregiver's Burden Scale (CBS), Hospital Anxiety and Depression Scale (HADS), SF-36 and 20-item Burden Assessment Schedule (BAS)...
November 15, 2015: Journal of the Neurological Sciences
Fabricio F Oliveira, Fernando C Machado, Gustavo Sampaio, Sheilla M C Marin, Elizabeth S Chen, Marilia C Smith, Paulo H F Bertolucci
INTRODUCTION: Neuropsychiatric and epidemiological patterns may compensate for insufficient specificity of diagnostic criteria of Lewy body dementia (LBD) syndromes in differential analysis with Alzheimer disease (AD) dementia. We aimed to compare and distinguish demographic and neuropsychiatric features between LBD and APOE-ε3/ε3 late-onset AD. METHODS: A total of 39 consecutive patients with Parkinson disease dementia or dementia with Lewy bodies were matched with 39 APOE-ε3/ε3 patients with late-onset AD according to sex and Mini-Mental State Examination scores, and evaluated for education, age at disease onset, lifetime sanitary conditions, anthropometric measures, alcohol use, smoking, history of head trauma or bacterial infections, family history of neurodegenerative diseases, caregiver burden, functional independence, cognitive decline, neuropsychiatric symptoms, and pharmacological treatment...
August 2015: Neurologist
E Oikonomou, Th Paparrigopoulos
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease affecting 1-2% of the population over 60. Although diagnosed by its characteristic motor manifestations, PD may be preceded, and is frequently accompanied, by a wide range of psychiatric and cognitive symptoms. These symptoms are often more debilitating than its motor complications and it is nowadays appreciated that they can be an important cause of excess disability in PD, frequently necessitating hospitalization and institutionalization...
April 2015: Psychiatrikē, Psychiatriki
Songul Senadim, Murat Cabalar, Habip Gedik, Ali Bayram Kasim, Anıl Bulut, Vildan Yayla, Zeynep Erdogdu
In this study, we aimed to compare patients' characteristics, comorbid risk factors, medical supplies, and caregivers' demographics between stroke patients and patients with other chronic neurological diseases receiving home health services. In our study, between November 2013 and March 2014, chronic neurological disease (CND) patients having home health services were enrolled in the study. During patient visits, patients were assessed by the questionnaire comprising the modified Rankin scale (mRS), Barthel index, Zarit caregiver burden scale, and mini nutritional assessment (MNA)...
March 2016: Acta Neurologica Belgica
Chris Stinton, Ian McKeith, John-Paul Taylor, Louise Lafortune, Eneida Mioshi, Elijah Mak, Victoria Cambridge, James Mason, Alan Thomas, John T O'Brien
OBJECTIVE: The authors examined research on effects, costs, and patient and caregiver views of pharmacological management strategies for Lewy body dementia. METHOD: Studies were identified through bibliographic databases, trials registers, gray literature, reference lists, and experts. The authors used the search terms "Lewy or parkinson" and "dementia" through March 2015 and used the following inclusion criteria: participants with diagnoses of Lewy body dementia, dementia with Lewy bodies, or Parkinson's disease dementia (or participants' caregivers); investigation of pharmacological management strategies; outcome measures and test scores reported...
August 1, 2015: American Journal of Psychiatry
Pablo Martinez-Martin, Carmen Rodriguez-Blazquez, Maria João Forjaz, Belén Frades-Payo, Luis Agüera-Ortiz, Daniel Weintraub, Ana Riesco, Monica M Kurtis, Kallol Ray Chaudhuri
INTRODUCTION: In Parkinson's disease (PD), neuropsychiatric symptoms (NPS) can be particularly burdensome for caregivers. The main goal of this study was to assess the impact of NPS, assessed by means of a new specific scale, on caregiver burden. METHODS: A sample of 584 pairs of PD patients and their primary caregivers was studied. Patients' NPS were measured with the Scale for Evaluation of Neuropsychiatric Disorders in PD (SEND-PD), and the Zarit Caregiver Burden Inventory was used to quantify caregiver burden...
June 2015: Parkinsonism & related Disorders
Yoon-Sang Oh, Ji E Lee, Phil Hyu Lee, Joong-Seok Kim
OBJECTIVE: Neuropsychiatric symptoms are common in Parkinson's disease dementia (PDD). Frequent and severe neuropsychiatric symptoms create high levels of distress for patients and caregivers, decreasing their quality of life. The aim of this study was to investigate neuropsychiatric symptoms that may contribute to increased caregiver burden in PDD patients. METHODS: Forty-eight PDD patients were assessed using the 12-item Neuropsychiatric Inventory (NPI) to determine the frequency and severity of mental and behavioral problems...
January 2015: Journal of Movement Disorders
Stella Karantzoulis, James E Galvin
Dementia with Lewy bodies (DLB) is the second most common form of dementia after Alzheimer disease (AD). DLB is characterized pathologically by Lewy body and Lewy neuritic pathology, often with variable levels of Alzheimer-type pathology. Core clinical features include fluctuating cognition, visual hallucinations, and parkinsonism resulting in greater impairments of quality of life, more caregiver burden, and higher health-related costs compared with AD. These issues, together with a high sensitivity to adverse events with treatment with antipsychotic agents, make the need for an early and accurate diagnosis of DLB essential...
September 1, 2013: Current Translational Geriatrics and Experimental Gerontology Reports
Alyce Russell, Alesya Drozdova, Wei Wang, Meghan Thomas
Dementia is the leading cause of disability worldwide among chronic diseases in the elderly and is a major contributor to mortality. Importantly, dementia that develops as a comorbid condition significantly compounds the burden of disease on the person, their caregivers and the health care system. Dementia is a frequent comorbidity of Parkinson's disease (PD) and about 80% of people with PD will develop dementia during the course of the disease. Incidence of dementia in PD ranges from 54.7 to 107.14 per 1000 person-years while point prevalence estimates range from 19...
2014: CNS & Neurological Disorders Drug Targets
M Coelho, M J Marti, C Sampaio, J J Ferreira, F Valldeoriola, M M Rosa, E Tolosa
BACKGROUND AND PURPOSE: Handicap has not been explored as a patient-centred outcome measure in Parkinson's disease (PD). The clinical features and medication use in late stages of PD (LS-PD) were reported previously. METHODS: Handicap, medical conditions, use of healthcare resources and the impact of LS-PD upon caregivers were characterized in a cross-sectional study of LS-PD stages 4 or 5 of Hoehn and Yahr (H&Y). Handicap was measured using the London Handicap Scale (LHS: 0, maximal handicap; 1, no handicap)...
February 2015: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Kenya Nishioka, Ryota Tanaka, Hideki Shimura, Kazuoki Hirano, Taku Hatano, Koichi Miyakawa, Heii Arai, Nobutaka Hattori, Takao Urabe
Patients with advanced-stage Parkinson's disease (PD) occasionally experience refractory depression or catatonic stupor. Electroconvulsive therapy (ECT) has been reported as a successful procedure for both severe psychosis and motor symptoms in patients with PD. Four patients with PD who were receiving ECT were quantitatively evaluated using the Unified PD Rating scale part III, Hoehn and Yahr scale, Barthel index, Neuropsychiatric Inventory, mini-mental state examination, Revised Hasegawa's Dementia scale, Beck's Depression Inventory, and Hamilton Rating Scale for Depression-17...
November 2014: Journal of Neural Transmission
Iracema Leroi, Richard Atkinson, Ross Overshott
OBJECTIVE: Memantine, an uncompetitive antagonist of N-methyl-d-aspartate receptors, may have a role in managing symptoms associated with dementia in Parkinson's disease (PDD), although its role in improving patient-reported outcomes (PROs) has not been extensively investigated. PROs may be more sensitive than standard psychometric measures for detecting change in complex conditions such as PDD. The aim of this study was to examine the effect of memantine on PROs: individually determined goals and health-related quality of life...
September 2014: International Journal of Geriatric Psychiatry
C L Dotchin, S-M Paddick, A R Longdon, A Kisoli, W K Gray, F Dewhurst, P Chaote, M Dewhurst, R W Walker
BACKGROUND: Caregiver burden includes the many physical, mental and socio-economic problems arising from caring for individuals with chronic and disabling diseases. Being a carer in sub-Saharan Africa (SSA), where little is known about chronic neurological conditions, may be extremely demanding. Conversely, multigenerational living may allow sharing of care among many caregivers. We wished to determine the relative burden of caring for two chronic neurodegenerative conditions (Parkinson's disease (PD) and dementia) in rural Tanzania...
April 2014: International Psychogeriatrics
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