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Ascending aorta aneurysm

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https://www.readbyqxmd.com/read/28102102/impact-of-thoracic-endovascular-aortic-repair-on-pulsatile-circumferential-and-longitudinal-strain-in-patients-with-aneurysm
#1
Foeke J H Nauta, Guido H W van Bogerijen, Chiara Trentin, Michele Conti, Ferdinando Auricchio, Frans L Moll, Joost A van Herwaarden, Santi Trimarchi
PURPOSE: To quantify both pulsatile longitudinal and circumferential aortic strains before and after thoracic endovascular aortic repair (TEVAR), potentially clarifying TEVAR-related complications. METHODS: This retrospective study assessed the impact of TEVAR on pulsatile aortic strains through custom developed software and cardiac-gated computed tomography imaging of 8 thoracic aneurysm patients (mean age 71.0±8.2 years; 6 men) performed before TEVAR and during follow-up (median 0...
January 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28099082/therapeutics-targeting-drivers-of-thoracic-aortic-aneurysms-and-acute-aortic-dissections-insights-from-predisposing-genes-and-mouse-models
#2
Dianna M Milewicz, Siddharth K Prakash, Francesco Ramirez
Thoracic aortic diseases, including aneurysms and dissections of the thoracic aorta, are a major cause of morbidity and mortality. Risk factors for thoracic aortic disease include increased hemodynamic forces on the ascending aorta, typically due to poorly controlled hypertension, and heritable genetic variants. The altered genes predisposing to thoracic aortic disease either disrupt smooth muscle cell (SMC) contraction or adherence to an impaired extracellular matrix, or decrease canonical transforming growth factor beta (TGF-β) signaling...
January 14, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/28094007/obtaining-the-biomechanical-behavior-of-ascending-aortic-aneurysm-via-the-use-of-novel-speckle-tracking-echocardiography
#3
Mohammed Alreshidan, Nastaran Shahmansouri, Jennifer Chung, Vynka Lash, Alexander Emmott, Richard L Leask, Kevin Lachapelle
INTRODUCTION: Ex vivo measurement of ascending aortic biomechanical properties may help understand the risk for rupture or dissection of dilated ascending aortas. A validated in vivo method that can predict aortic biomechanics does not exist. Speckle tracking transesophageal echocardiography (TEE) has been used to measure ventricular stiffness; we sought to determine whether speckle TEE could be adapted to estimate aortic stiffness in vivo and compare these findings with those obtained by ex vivo tissue measurements...
December 20, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28055841/a-regression-method-based-on-non-invasive-clinical-data-to-predict-the-mechanical-behavior-of-ascending-aorta-aneurysmal-tissuea-regression-method-based-on-non-invasive-clinical-data-to-predict-the-mechanical-behavior-of-ascending-aorta-aneurysmal-tissue
#4
Ferdinando Auricchio, Anna Ferrara, Ettore Lanzarone, Simone Morganti, Pasquale Totaro
GOAL: Ascending aorta aneurysms represent a severe life-threatening condition associated with asymptomatic risk of rupture. Prediction of aneurysm evolution and rupture is one of the hottest investigation topics in cardiovascular science, and the decision on when and whether to surgically operate is still an open question. We propose an approach for estimating the patient-specific ultimate mechanical properties and stress-stretch characteristics based on non-invasive data. METHODS: As for the characteristics, we consider a non-linear constitutive model of the aortic wall and assume patient-specific model coefficients...
December 29, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28040678/aortic-root-aneurysm-extending-into-the-arch-as-a-rare-complication-of-kawasaki-disease-surgical-management
#5
Zoltan Szalay, Vassil Papantchev, Thomas Walther
An aortic aneurysm complicating Kawasaki disease (KD) is extremely rare. We herein report a case of 48-year-old KD patient with severe aortic regurgitation, aneurysm of the aortic root, ascending aorta and aortic arch, and giant heavily calcified coronary aneurysms. The patient underwent successful surgical management. This case raises some unusual technical issues, which are discussed. A review of the literature is also offered.
December 30, 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28029670/evaluation-of-distensibility-and-stiffness-of-ascending-aortic-aneurysm-using-magnetic-resonance-imaging
#6
K K Tiwari, S Bevilacqua, G Aquaro, P Festa, L Ait-Ali, M Solinas
INTRODUCTION: Magnetic resonance imaging emerging as a new tool for the diagnosis and evaluation of ascending aortic aneurysm. The aim of our study is to evaluate in vivo distensibility and pulse wave velocity of the aortic wall using functional magnetic resonance imaging technique. METHODS: We enrolled 25 patients undergoing surgery for ascending aortic aneurysm and or aortic valve replacement for a period of 8 months. Preoperatively, all the patients underwent functional MRI study of the aorta...
October 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28027889/extensibility-and-distensibility-of-the-thoracic-aorta-in-patients-with-aneurysm
#7
H W L de Beaufort, F J H Nauta, M Conti, E Cellitti, C Trentin, E Faggiano, G H W van Bogerijen, C A Figueroa, F L Moll, J A van Herwaarden, F Auricchio, S Trimarchi
OBJECTIVES: Reference values of aortic deformation during the cardiac cycle can be valuable for the pre-operative planning of thoracic endovascular aortic repair (TEVAR) and for facilitating computational fluid dynamics. This study aimed to quantify normal aortic extensibility (longitudinal extension) and distensibility (radial expansion), as well as pulsatile strain, in a group of 10 (>60 years) individuals with abdominal or thoracic aortic aneurysms. METHODS: ECG gated CT images of the thoracic aorta were reconstructed into virtual 3D models of aortic geometry...
December 24, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28018834/detailed-measurement-of-wall-strain-with-3d-speckle-tracking-in-the-aortic-root-a-case-of-bionic-support-for-clinical-decision-making
#8
Sebastian Vogt, Konstantinos Karatolios, Andreas Wittek, Christopher Blasé, Anette Ramaswamy, Nikolas Mirow, Rainer Moosdorf
Three-dimensional (3D) wall motion tracking (WMT) based on ultrasound imaging enables estimation of aortic wall motion and deformation. It provides insights into changes in vascular compliance and vessel wall properties essential for understanding the pathogenesis and progression of aortic diseases. In this report, we employed the novel 3D WMT analysis on the ascending aorta aneurysm (AA) to estimate local aortic wall motion and strain in case of a patient scheduled for replacement of the aortic root. Although progression of the diameter indicates surgical therapy, at present we addressed the question for optimal surgical time point...
December 2016: Thoracic and Cardiovascular Surgeon Reports
https://www.readbyqxmd.com/read/28018506/recurrence-of-aneurysm-of-the-ascending-aorta-after-patch-repair-the-fate-of-an-aortic-patch
#9
Masato Tochii, Kentaro Amano, Yusuke Sakurai, Hiroshi Ishikawa, Michiko Ishida, Yoshiro Higuchi, Yasushi Takagi
Pseudoaneurysm of the ascending aorta is a rare but life- threatening complication after aortic cannulation and cardiovascular surgery, and it has the potential to rupture. We experienced a rare case of recurrence of aneurysm of the ascending aorta 7 years after patch repair of a small aneurysm at an aortic cannulation site. The repaired aorta had been wrapped with a Teflon felt strip during the previous surgery, and the wrapped aorta had become thin with deterioration of the normal structure of the aortic wall...
2016: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/27989994/functional-assessment-of-thoracic-aortic-aneurysms-the-future-of-risk-prediction
#10
REVIEW
Pouya Youssefi, Rajan Sharma, C Alberto Figueroa, Marjan Jahangiri
INTRODUCTION: Treatment guidelines for the thoracic aorta concentrate on size, yet acute aortic dissection or rupture can occur when aortic size is below intervention criteria. Functional imaging and computational techniques are a means of assessing haemodynamic parameters involved in aortic pathology. SOURCES OF DATA: Original articles, reviews, international guidelines. AREAS OF AGREEMENT: Computational fluid dynamics and 4D flow MRI allow non-invasive assessment of blood flow parameters and aortic wall biomechanics...
December 17, 2016: British Medical Bulletin
https://www.readbyqxmd.com/read/27988155/inflammatory-aortic-aneurysm-in-a-young-patient-with-ankylosing-spondylitis
#11
Robert J H Miller, Randy Moore, Byung Kim, Diane Mosher, Nanette Alvarez
Inflammatory conditions are a rare cause of aortic aneurysms, accounting for 3% to 10% of cases. Patients with ankylosing spondylitis uncommonly present with ascending aortic aneurysms related to long-standing, aggressive disease. We review the case of a young man with ankylosing spondylitis exhibiting complex inflammatory aortic aneurysms atypically involving the abdominal and descending thoracic aorta, as well as ectasia of medium-sized visceral vessels. Inflammatory aneurysms require a multidisciplinary approach incorporating diagnostic modalities to confirm etiology, targeted immunosuppressive therapy to control disease activity, and aneurysm repair...
December 14, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27982548/syphilitic-aortitis-and-its-complications-in-the-modern-era
#12
Francesco Drago, Giulia Merlo, Alfredo Rebora, Aurora Parodi
INTRODUCTION: Aortitis is a well recognized manifestation of the tertiary stage of syphilis. EVIDENCE ACQUISITION: Although often regarded as an unexpected diagnosis, actually new cases of cardiovascular syphilis continue to be reported. Presumably, Treponema pallidum invades the aortic wall and the inflammatory response progresses towards obliterative endarteritis and necrosis of the muscular and elastic fibers in the aortic media. The consequent weakening of the aortic wall can lead to severe complications, represented by aortic aneurysm, aortic valvular insufficiency, aortic root dilation and coronary ostial stenosis...
December 16, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27955909/cardiovascular-operations-for-loeys-dietz-syndrome-intermediate-term-results
#13
Nishant D Patel, Todd Crawford, J Trent Magruder, Diane E Alejo, Narutoshi Hibino, James Black, Harry C Dietz, Luca A Vricella, Duke E Cameron
OBJECTIVES: Early experience with Loeys-Dietz syndrome (LDS) suggested an aggressive aortopathy with high risk of aneurysm dissection and rupture at young ages and at smaller aortic diameters than in other connective tissue disorders. We reviewed our experience with LDS to re-examine our indications and outcomes of surgical management. METHODS: We reviewed all patients with a diagnosis of LDS who underwent cardiovascular surgery at our institution. The primary endpoint was mortality, and secondary endpoints included postoperative complications and need for reintervention...
November 16, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27942519/isolated-idiopathic-aortitis-with-an-unusually-thickened-aortic-wall-case-report
#14
John Yoon, Irina Pa-C Gruboy, Altheeb Zaid, Shah G Salil, Mark Connolly, Wilbert S Aronow, Walid Elozomor, Jamshed Zuberi
Aortitis includes a broad range of disorders involving inflammation of the aorta. While most forms of aortitis can be linked to a specific cause, patients with idiopathic aortitis (IDA), are asymptomatic and usually diagnosed after surgical removal. The specific pathophysiology is not well understood, but can be strongly associated with tobacco smoking, young age at presentation, and family history of aortic aneurysm. Wall thickening is the most common physical characteristic of aortitis, and the inflammation can affect any layer of the aorta...
November 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27939578/disseminated-aspergillosis-in-an-immunocompetent-patient-with-detectable-bis-methylthio-gliotoxin-and-negative-galactomannan
#15
Matxalen Vidal-García, Pilar Sáncehez-Chueca, María Pilar Domingo, Carlos Ballester, Lourdes Roc, Isabel Ferrer, María José Revillo, Julián Pardo, Eva María Gálvez, Antonio Rezusta
BACKGROUND: Disseminated invasive aspergillosis is an exceptional finding in immunocompetent hosts. As in immunocompromised patients, it has high mortality rates. Early diagnostic methods are required in order to properly manage the patient. Bis(methylthio)gliotoxin (bmGT) is a novel biomarker, useful in onco-hematological patients. CASE REPORT: A 70-year-old male, with non-insulin dependent type II diabetes mellitus and a past surgery history of aortic valve replacement with coronary by-pass five years ago, was seen in the emergency department with blurred vision...
December 8, 2016: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/27909281/-transaortic-thoracic-endovascular-aortic-repair-via-right-anterior-mini-thoracotomy-report-of-a-case
#16
Keitaro Okamoto, Tomoyuki Wada, Hirofumi Anai, Satoshi Takebayashi, Takashi Shuto, Takayuki Kawashima, Kazuki Mori, Norio Hongo, Noritaka Kamei, Hiromu Mori, Shinji Miyamoto
An 81-year-old man presented with ruptured thoracic aortic aneurysm under stable condition. He had been suffering from chronic obstructive pulmonary disease, chronic renal failure and rheumatoid arthritis. We performed hybrid thoracic endovascular aortic repair via right anterior mini-thoracotomy inserting a device through a conduit on the ascending aorta. The patient was discharged without aorta-related complications.
December 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27908818/ascending-aorta-to-hepatic-and-mesenteric-artery-bypassing-in-patients-with-chronic-mesenteric-ischemia-and-extensive-aortic-disease-a-case-report-and-review-of-the-literature
#17
James Barr, John Kokotsakis, Pantelis Tsipas, Prodromos Papapavlou, Konstantinos Velissarios, Theodoros Kratimenos, Thanos Athanasiou
Chronic mesenteric ischemia (CMI) is a rare disorder caused by severe stenosis of the mesenteric arterial supply that results in postprandial pain and weight loss. Treatment options are surgical or endovascular. Surgical bypass can be performed in an antegrade fashion from the supraceliac abdominal aorta (AA) or the distal descending thoracic aorta or in a retrograde fashion from the infrarenal aorta or the common iliac artery. However, in some patients with disease of the descending thoracic aorta or the AA, another site for the proximal anastomosis needs to be found...
November 28, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27890843/total-endovascular-aortic-repair-in-a-patient-with-marfan-syndrome
#18
Mau Amako, Rafaëlle Spear, Rachel E Clough, Adrien Hertault, Richard Azzaoui, Teresa Martin-Gonzalez, Jonathan Sobocinski, Stéphan Haulon
BACKGROUND: The aim of this study is to describe a total endovascular aortic repair with branched and fenestrated endografts in a young patient with Marfan syndrome and a chronic aortic dissection. Open surgery is the gold standard to treat aortic dissections in patients with aortic disease and Marfan syndrome. METHODS: In 2000, a 38-year-old man with Marfan syndrome underwent open ascending aorta repair for an acute type A aortic dissection. One year later, a redo sternotomy was performed for aortic valve replacement...
November 24, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27888778/loss-of-mechanical-directional-dependency-of-the-ascending-aorta-with-severe-medial-degeneration
#19
Jennifer Chung, Kevin Lachapelle, Raymond Cartier, Rosaire Mongrain, Richard L Leask
Biomechanical characterization of the aortic wall may help risk stratify patients with aneurysms. We investigated the degree of anisotropy, the directional dependency of mechanical properties, in control and aneurysmal ascending aortic tissue. We hypothesized that medial degeneration and aortic wall remodeling as found in aneurysmal tissue alter energy loss in both the circumferential and longitudinal directions, thereby reducing anisotropy. Aneurysmal and control ascending aortic tissue excised during surgery was subjected to biaxial tensile testing...
January 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/27879251/altered-smooth-muscle-cell-force-generation-as-a-driver-of-thoracic-aortic-aneurysms-and-dissections
#20
Dianna M Milewicz, Kathleen M Trybus, Dong-Chuan Guo, H Lee Sweeney, Ellen Regalado, Kristine Kamm, James T Stull
The importance of maintaining contractile function in aortic smooth muscle cells (SMCs) is evident by the fact that heterozygous mutations in the major structural proteins or kinases controlling contraction lead to the formation of aneurysms of the ascending thoracic aorta that predispose to life-threatening aortic dissections. Force generation by SMC requires ATP-dependent cyclic interactions between filaments composed of SMC-specific isoforms of α-actin (encoded by ACTA2) and myosin heavy chain (MYH11). ACTA2 and MYH11 mutations are predicted or have been shown to disrupt this cyclic interaction predispose to thoracic aortic disease...
January 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
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