keyword
https://read.qxmd.com/read/38534478/stress-load-and-ascending-aortic-aneurysms-an-observational-longitudinal-single-center-study-using-computational-fluid-dynamics
#1
JOURNAL ARTICLE
Fabiula Schwartz de Azevedo, Gabriela de Castro Almeida, Bruno Alvares de Azevedo, Ivan Fernney Ibanez Aguilar, Bruno Nieckele Azevedo, Pedro Soares Teixeira, Gabriel Cordeiro Camargo, Marcelo Goulart Correia, Angela Ourivio Nieckele, Glaucia Maria Moraes Oliveira
Ascending aortic aneurysm (AAoA) is a silent disease with high mortality; however, the factors associated with a worse prognosis are not completely understood. The objective of this observational, longitudinal, single-center study was to identify the hemodynamic patterns and their influence on AAoA growth using computational fluid dynamics (CFD), focusing on the effects of geometrical variations on aortic hemodynamics. Personalized anatomic models were obtained from angiotomography scans of 30 patients in two different years (with intervals of one to three years between them), of which 16 (53%) showed aneurysm growth (defined as an increase in the ascending aorta volume by 5% or more)...
February 22, 2024: Bioengineering
https://read.qxmd.com/read/38533578/aortic-events-and-relative-survival-in-patients-with-moderately-dilated-proximal-thoracic-aorta
#2
JOURNAL ARTICLE
Emelie Carlestål, Anders Franco-Cereceda, Christian Olsson
Objectives. This study describes growth, local and remote aortic events, and survival in patients with proximal (root, ascending) aortic diameters just below threshold for operation. Methods. Patients with proximal aortic diameter of 4.5 to 5.4 cm at baseline, were followed with serial computed tomography studies and data collected retrospectively. Aortic growth rate was estimated using mixed effects modelling. Clinical and radiological features associated with outcomes (all-cause death, aortic death, local or remote aortic events (dissection, rupture, intramural hematoma, or intervention)) were assessed with Cox analysis...
December 2024: Scandinavian Cardiovascular Journal: SCJ
https://read.qxmd.com/read/38508847/new-findings-on-ascending-aortic-dilation-in-coarctation-of-the-aorta-expanding-perspectives
#3
EDITORIAL
Daniel Rinnström, Bengt Johansson
No abstract text is available yet for this article.
March 26, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38508846/coarctation-of-aorta-with-tricuspid-aortic-valve-is-not-associated-with-ascending%C3%A2-aortic%C3%A2-aneurysm
#4
JOURNAL ARTICLE
Alexander C Egbe, William R Miranda, Omar Abozied, C Charles Jain, Luke J Burchill, Snigdha Karnakoti, Marwan H Ahmed, Christopher J Francois, Heidi M Connolly
BACKGROUND: Aortic aneurysm is common in patients with coarctation of aorta (COA), but it is unclear whether the risk of aortic aneurysms is due to COA or related to the presence of other risk factors such as bicuspid aortic valve (BAV) and hypertension. OBJECTIVES: The purpose of this study was to assess the relationship among COA, BAV, and thoracic aortic aneurysms. METHODS: A total of 867 patients with COA (COA group) were matched 1:1:1 to 867 patients with isolated BAV (BAV group) and 867 patients without structural heart disease (SHD) (no-SHD group)...
March 26, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38508639/predictive-machine-learning-models-for-ascending-aortic-dilatation-in-patients-with-bicuspid-and-tricuspid-aortic-valves-undergoing-cardiothoracic-surgery-a-prospective-single-centre-and-observational-study
#5
JOURNAL ARTICLE
Bamba Gaye, Maxime Vignac, Jesper R Gådin, Magalie Ladouceur, Kenneth Caidahl, Christian Olsson, Anders Franco-Cereceda, Per Eriksson, Hanna M Björck
OBJECTIVES: The objective of this study was to develop clinical classifiers aiming to identify prevalent ascending aortic dilatation in patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV). DESIGN AND SETTING: A prospective, single-centre and observational cohort. PARTICIPANTS: The study involved 543 BAV and 491 TAV patients with aortic valve disease and/or ascending aortic dilatation, excluding those with coronary artery disease, undergoing cardiothoracic surgery at the Karolinska University Hospital (Sweden)...
March 20, 2024: BMJ Open
https://read.qxmd.com/read/38508054/flow-patterns-in-ascending-aortic-aneurysms-determining-the-role-of-hypertension-using-phase-contrast-magnetic-resonance-and-computational-fluid-dynamics
#6
JOURNAL ARTICLE
M J F G Ramaekers, I B van der Vlugt, J J M Westenberg, R Perinajová, H J Lamb, J E Wildberger, S Kenjereš, S Schalla
Thoracic aortic aneurysm (TAA) is a local dilation of the thoracic aorta. Although universally used, aneurysm diameter alone is a poor predictor of major complications such as rupture. There is a need for better biomarkers for risk assessment that also reflect the aberrant flow patterns found in TAAs. Furthermore, hypertension is often present in TAA patients and may play a role in progression of aneurysm. The exact relation between TAAs and hypertension is poorly understood. This study aims to create a numerical model of hypertension in the aorta by using computational fluid dynamics...
March 16, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38502030/asymptomatic-giant-ascending-aortic-aneurysm-a-challenging-surgical-strategy-for-a-silent-bicuspid-aortopathy
#7
JOURNAL ARTICLE
Maria Grazia Romeo, Emanuele Pilato, Raffaele Giordano, Giuseppe Comentale, Gabriele Iannelli, Domenico Romeo, Bruna Miserrafiti, Luigi Di Tommaso
We report the case of an incidental finding of a huge aneurysm of the ascending aorta with a congenital bicuspid aortic valve type 0-lateral. This severe condition was totally unknown to the patient, who was asymptomatic for cardiovascular disease. The aneurysmal mass involved the entire mediastinum, altering the normal anatomical relations, so the operative strategy was modified intraoperatively, tailoring the surgical technique to the anatomical conditions found. Despite a delayed awakening, the patient had an uncomplicated postoperative course...
March 18, 2024: Monaldi Archives for Chest Disease
https://read.qxmd.com/read/38487034/acute-dissection-of-a-syphilitic-saccular-aneurysm-of-the-ascending-aorta-and-arch-in-a-hypertensive-patient-a-rare-phenomenon
#8
Hubert Daisley, Dennecia George, Johann Daisley
We report the case of a 77-year-old male who suffered from hypertension and died suddenly. At autopsy, he was found to have hypertensive cardiomegaly and a dissecting syphilitic saccular aneurysm of the ascending aorta and arch with tamponade. Chronic aortic regurgitation, which is often seen in syphilitic aortitis, produces an additive effect to the concentric left ventricular hypertrophy seen in hypertension.
2024: Autopsy & Case Reports
https://read.qxmd.com/read/38476287/tertiary-syphilis-and-cardiovascular-disease-the-united-triad-case-report
#9
Taha Berhil, Fatima Zohra Radi, Badre El Boussaadani, Zainab Raissouni
BACKGROUND: Syphilis, owing to its natural course, can lead to long-term damage to the aortic valve, such as insufficiency and rarely stenosis, ostial coronary stenosis, and syphilitic aortitis. Cardiovascular involvement alongside neurological involvement dominates the prognosis. This should no longer be seen, thanks to awareness and prevention programmes, medical treatment, and antibiotics. CASE SUMMARY: We report a case of a 54-year-old chronic smoker with no previous history, admitted for respiratory distress amid an impaired general condition...
March 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38471650/outcomes-for-patients-undergoing-transcatheter-aortic-valve-replacement-with-ascending-aorta-dilation
#10
JOURNAL ARTICLE
Dejing Feng, Jie Zhao, Guannan Niu, Yuxuan Zhang, Can Wang, Yang Chen, Zheng Zhou, Hongliang Zhang, Zhenyan Zhao, Yunqing Ye, Zhe Li, Haiyan Xu, Moyang Wang, Yongjian Wu
BACKGROUND: We aim to compare the short and long-term outcomes for aortic stenosis (AS) patients undergone TAVR with and without ascending aorta dilation (AAD). METHODS: Consecutive patients diagnosed with native severe AS who underwent TAVR from September 2012 to September 2021 were enrolled. They were stratified into the moderate/severe dilation group (greatest ascending aorta width ≥ 45 mm) and the non/mild dilation group. Survival outcomes were illustrated using Kaplan-Meier curves and evaluated with the log-rank test...
March 10, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38457932/patient-specific-analysis-of-bicuspid-aortic-valve-hemodynamics-using-a-fully-coupled-fluid-structure-interaction-model
#11
JOURNAL ARTICLE
Tongran Qin, Wenbin Mao, Andrés Caballero, Norihiko Kamioka, Stamatios Lerakis, Santiago Lain, John Elefteriades, Liang Liang, Wei Sun
Bicuspid aortic valve (BAV), the most common congenital heart disease, is prone to develop significant valvular dysfunction and aortic wall abnormalities such as ascending aortic aneurysm. Growing evidence has suggested that abnormal BAV hemodynamics could contribute to disease progression. In order to investigate BAV hemodynamics, we performed 3D patient-specific fluid-structure interaction (FSI) simulations with fully coupled blood flow dynamics and valve motion throughout the cardiac cycle. Results showed that the hemodynamics during systole can be characterized by a systolic jet and two counter-rotating recirculation vortices...
February 19, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38455696/pulmonary-artery-aneurysm-associated-with-sarcoidosis-in-a-75-year-old-with-heart-failure-the-challenges-of-diagnosis-and-management
#12
JOURNAL ARTICLE
Isabel Cruz, Rafaela Lopes, Bruno Bragança, Inês Campos, Inês Gonçalves, Rui P Santos, Aurora Andrade
INTRODUCTION: Pulmonary artery aneurysm (PAA) is a rare abnormality of pulmonary vasculature. It can be idiopathic or secondary to various pathologies, frequently with multiple factors leading to its formation. We report the case of a man with concomitant sarcoidosis and PAA. CASE DESCRIPTION: A 75-year-old male with a diagnosis of pulmonary sarcoidosis was referred to the Cardiology department due to heart failure with reduced left ventricular ejection fraction (LVEF)...
2024: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/38435381/height-and-body-surface-area-versus-wall-stress-for-stratification-of-mid-term-outcomes-in-ascending-aortic-aneurysm
#13
JOURNAL ARTICLE
Siavash Zamirpour, Yue Xuan, Zhongjie Wang, Axel Gomez, Joseph R Leach, Dimitrios Mitsouras, David A Saloner, Julius M Guccione, Liang Ge, Elaine E Tseng
OBJECTIVES: Current diameter-based guidelines for ascending thoracic aortic aneurysms (aTAA) do not consistently predict risk of dissection/rupture. ATAA wall stresses may enhance risk stratification independent of diameter. The relation of wall stresses and diameter indexed to height and body surface area (BSA) is unknown. Our objective was to compare aTAA wall stresses with indexed diameters in relation to all-cause mortality at 3.75 years follow-up. METHODS: Finite element analyses were performed in a veteran population with aortas ≥ 4...
April 2024: IJC Heart & Vasculature
https://read.qxmd.com/read/38404628/navigating-the-challenges-of-bicuspid-aortic-valve-aortopathy
#14
REVIEW
Sai Gautham Kanagala, Aanchal Sawhney, Kinna Parikh, Vasu Gupta, Talha Mahmood, Fnu Anamika, Rohit Jain, Nikita Garg
Bicuspid aortic valve (BAV) is a congenital heart defect that affects 0.5-2% of the general population with familial predominance. The modifications in hemodynamics and structure change at cellular level contribute to the dilation of aorta, resulting in bicuspid aortopathy, which can result in catastrophic aortic events. The American Heart Association recommends screening first-degree relatives of patients with bicuspid aortic valve and aortic root disease. BAV may or may not be associated with a syndrome, with the non-syndromic variety having a higher chance of predisposition to congenital and vascular abnormalities...
September 30, 2023: Global Cardiology Science & Practice
https://read.qxmd.com/read/38403074/4d-flow-mri-aortic-cross-sectional-pressure-changes-and-their-associations-with-flow-patterns-in-health-and-aneurysm
#15
JOURNAL ARTICLE
Kevin Bouaou, Thomas Dietenbeck, Gilles Soulat, Ioannis Bargiotas, Sophia Houriez-Gombaud-Saintonge, Alain De Cesare, Umit Gencer, Alain Giron, Elena Jiménez, Emmanuel Messas, Didier Lucor, Emilie Bollache, Elie Mousseaux, Nadjia Kachenoura
BACKGROUND: Ascending thoracic aortic aneurysm (ATAA) is a silent and threatening dilation of the ascending aorta (AscAo). Maximal aortic diameter which is currently used for ATAA patients management and surgery planning has been shown to inadequately characterize risk of dissection in a large proportion of patients. Our aim was to propose a comprehensive quantitative evaluation of aortic morphology and pressure-flow-wall associations from 4D flow MRI data in healthy aging and in patients with ATAA...
February 23, 2024: Journal of Cardiovascular Magnetic Resonance
https://read.qxmd.com/read/38398265/late-post-dissection-dynamic-intermittent-malperfusion-of-the-aortic-arch-in-association-with-a-rare-heterogenous-lox-gene-variation
#16
Barbara Leclercq, Julien Bertolino, Alexandre Rossillon, Vlad Gariboldi, Sarah El Harake, François Silhol, Michel Bartoli, Bernard Vaisse, Axel Bartoli, Gabrielle Sarlon-Bartoli
Late ischaemic consequences of type A aortic dissection are rare. We present a 6-year late complication of type A aortic dissection treated by Bentall surgery in a 41-year-old patient. The patient presented with several episodes of lipothymia associated with hypertensive attacks with anisotension, cervicalgia, hemicranial headache, abdominal pain and lower limb slipping initially on exertion and later at rest. On dynamic examination, we diagnosed an intermittent dynamic occlusion of the aortic arch and rare LOX gene variation, which is considered to be associated with aneurysm or dissection of the ascending aorta in young patients...
February 7, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38380181/case-report-incidental-finding-of-an-atresia-of-the-inferior-vena-cava-a-challenge-for-cardiac-surgery
#17
Joscha Buech, Caroline Radner, Thomas Fabry, Simon Rutkowski, Christian Hagl, Sven Peterss, Maximilian A Pichlmaier
Inferior vena cava atresia is a rare and usually asymptomatic condition. However, when these patients undergo cardiac surgery, it can present an unexpected and challenging situation for the surgeon. Specifically, adequate venous drainage during cardiopulmonary bypass (CPB) is a critical issue here and may require an extension of cannulation strategies. Adequate preoperative diagnostics, ideally with imaging modalities such as CT angiography or MRI, are required for optimal surgical planning. Here, we describe a rare case of thoracic ascending aortic aneurysm with concomitant inferior vena cava atresia that was successfully operated on...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38362350/the-antioxidant-nitric-oxide-quenching-agent-cobinamide-prevents-aortic%C3%A2-disease-in-a-mouse-model-of%C3%A2-marfan-syndrome
#18
JOURNAL ARTICLE
Hema Kalyanaraman, Darren E Casteel, Justin A Cabriales, John Tat, Shunhui Zhuang, Adriano Chan, Kenneth L Dretchen, Gerry R Boss, Renate B Pilz
Major pathologic changes in the proximal aorta underlie the life-threatening aortic aneurysms and dissections in Marfan Syndrome; current treatments delay aneurysm development without addressing the primary pathology. Because excess oxidative stress and nitric oxide/protein kinase G signaling likely contribute to the aortopathy, we hypothesized that cobinamide, a strong antioxidant that can attenuate nitric oxide signaling, could be uniquely suited to prevent aortic disease. In a well-characterized mouse model of Marfan Syndrome, cobinamide dramatically reduced elastin breaks, prevented excess collagen deposition and smooth muscle cell apoptosis, and blocked DNA, lipid, and protein oxidation and excess nitric oxide/protein kinase G signaling in the ascending aorta...
January 2024: JACC. Basic to Translational Science
https://read.qxmd.com/read/38345901/cannula-placement-for-cerebral-protection-without-circulatory-arrest-in-patients-undergoing-hemiarch-aortic-aneurysm-repair
#19
JOURNAL ARTICLE
Joseph C Sweeney, Jaimin R Trivedi, Toyokazu Endo, Akhila Ankem, Siddharth V Pahwa, Mark S Slaughter, Brian L Ganzel
BACKGROUND: Aortic aneurysms involving the proximal aortic arch, which require hemiarch-type repair, typically require circulatory arrest with antegrade cerebral perfusion. Left carotid antegrade cerebral perfusion (LCP) via distal arch cannulation without circulatory arrest was used in this study's patient population. The goal was to assess the operative efficiency and clinical outcomes of using a distal arch cannulation technique that would not require any hypothermic circulatory arrest (HCA) time compared with more traditional brachiocephalic artery cannulation with right-sided unilateral antegrade cerebral perfusion (RCP) and HCA...
February 12, 2024: Texas Heart Institute Journal
https://read.qxmd.com/read/38342167/positive-correlation-between-thoracic-aortic-diameter-and-intracranial-aneurysm-size-an-observational-cohort-study
#20
JOURNAL ARTICLE
Ville Rantasalo, Jarmo Gunn, Emily Pan, Tuomas Kiviniemi, Jussi Hirvonen, Melissa Rahi, Terhi Fordell, Jaakko K Rinne, Dan Laukka
OBJECTIVE: To investigate the association between intracranial aneurysms (IA) and thoracic aortic diameter. METHODS: This observational cohort study examined thoracic aortic diameters in IA patients. Patients were categorized by IA size (<7mm and ≥7mm) and IA status (ruptured / unruptured) based on radiological findings. We investigated the association between thoracic aortic diameter and IA size and status using binary and linear regression as univariate and multivariable analyses...
February 9, 2024: World Neurosurgery
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