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https://www.readbyqxmd.com/read/29305041/arthroscopic-treatment-of-osteochondral-lesions-of-the-talus-using-juvenile-articular-cartilage-allograft-and-autologous-bone-marrow-aspirate-concentration
#1
Bridget A DeSandis, Amgad M Haleem, Carolyn M Sofka, Martin J O'Malley, Mark C Drakos
Juvenile allogenic chondrocyte implantation (JACI; DeNovo NT Natural Tissue Graft®; Zimmer, Warsaw, IN) with autologous bone marrow aspirate concentrate (BMAC) is a relatively new all-arthroscopic procedure for treating critical-size osteochondral lesions (OCLs) of the talus. Few studies have investigated the clinical and radiographic outcomes of this procedure. We collected the clinical and radiographic outcomes of patients who had undergone JACI-BMAC for talar OCLs to assess treatment efficacy and cartilage repair tissue quality using magnetic resonance imaging (MRI)...
January 2, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29282065/pulmonary-edema-following-central-nervous-system-lesions-induced-by-a-non-mouse-adapted-ev71-strain-in-neonatal-balb-c-mice
#2
Yuefei Jin, Chao Zhang, Rongguang Zhang, Jingchao Ren, Shuaiyin Chen, Meili Sui, Guangyuan Zhou, Dejian Dang, Jiehui Zhu, Huifen Feng, Yuanlin Xi, Haiyan Yang, Guangcai Duan
BACKGROUND: Enterovirus (EV) infection has been a serious health issue in Asia-Pacific region. It has been indicated that the occurrence of fatal hand foot and mouth disease (HFMD) cases following EV71 infection is mainly attributed to pulmonary edema. However, the development of pulmonary disorders after EV71 infection remains largely unknown. To establish an EV71-infected animal model and further explore the underlying association of central nervous system (CNS) invasion with pulmonary edema, we isolated a clinical source EV71 strain (ZZ1350) from a severe case in Henan Province...
December 28, 2017: Virology Journal
https://www.readbyqxmd.com/read/29245260/risk-factors-for-death-in-children-with-critical-and-severe-hand-foot-and-mouth-disease-in-chongqing-china-an-observational-study
#3
Gaihuan Zheng, Jiaoyang Cao, Jie Yu, Zhenzhen Zhang, Quanbo Liu, Junhua Chen
Hand-foot-and-mouth disease (HFMD) is a common childhood infection that may lead to serious complications and even death. Globally, epidemics of HFMD are increasing each year, especially in China. This study aimed to identify risk factors for death in children with critical and severe HFMD in Chongqing, China.We performed an observational study involving patients with critical and severe HFMD admitted to the Children's Hospital of Chongqing Medical University from January 2009 to December 2016. Overall, 179 patients aged 2 months to 16 years, were included; 127 died (non-survival group) and 52 survived (survival group); the case-fatality rate was 70...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29230289/accessory-anterolateral-talar-facet-impingement-with-tibialis-spastic-varus-foot
#4
Toshinori Kurashige
In recent years, some authors have reported accessory anterolateral talar facet impingement with flatfoot including peroneal spastic flatfoot. Conversely, to our knowledge, no case report has been published about accessory anterolateral talar facet impingement with tibialis spastic varus foot. We report the first case in a 22-year-old man with intellectual disability, bilateral cleft hands and type 1 diabetes mellitus. Since spraining his left ankle over a year earlier, he experienced left sinus tarsi pain while standing and walking...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29219020/correlation-of-mri-appearance-of-autologous-chondrocyte-implantation-in-the-ankle-with-clinical-outcome
#5
Keith W Chan, Richard D Ferkel, Brian Kern, Sarah S Chan, Gregory R Applegate
The objective of this study was to characterize magnetic resonance imaging (MRI) findings and correlate with clinical results in patients who underwent autologous chondrocyte implantation (ACI) of osteochondral lesions of the talus (OLT). METHODS: Twenty-four grafts were evaluated at a mean 65.8 months after ACI for OLT. MRI was performed on a 1.5-T GE scanner using multiple sequences. Graft appearance was compared with preoperative MRI and evaluated for 6 criteria: defect fill, surface regularity, signal pattern, bone marrow edema, subchondral plate irregularity, and presence of cystic lesions...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29179990/snakebite-by-micrurus-averyi-schmidt-1939-in-the-brazilian-amazon-basin-case-report-coral-snakebite-by-micrurus-averyi
#6
REVIEW
Iran Mendonça da Silva, Jorge Contreras Bernal, Pedro Ferreira Gonçalves Bisneto, Antônio Magela Tavares, Valéria Mourão de Moura, Claudio S Monteiro-Junior, Rima Raad, Paulo Sergio Bernarde, Jacqueline de Almeida Gonçalves Sachett, Wuelton Marcelo Monteiro
Micrurus snakes, commonly known as coral snakes, are responsible for 0.4% of the snakebites envenomings in Brazil. In this report, we describe a case of envenoming by Micrurus averyi, the black-headed coral snake, recorded in the western Brazilian Amazon. To the best of our knowledge, this is the first published case perpetrated by this species. The major complaint of the patient was an intense local pain and paresthesia. Examination of the bite site revealed edema extending from the left foot up the left leg that was accompanied by erythema involving the foot and distal third of the leg...
November 24, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29148070/growth-factors-for-diabetic-foot-ulcers-mixed-treatment-comparison-analysis-of-randomized-clinical-trials
#7
Kannan Sridharan, Gowri Sivaramakrishnan
AIMS: Topical growth factors accelerate wound healing in patients with diabetic foot ulcers (DFU). Due to the absence of head to head comparisons, we carried out Bayesian network meta-analysis to compare the efficacy and safety of growth factors. METHODS: Using an appropriate search strategy, randomized controlled trials on topical growth factors compared with standard of care in patients with DFU, were included. Proportion of patients with complete healing was the primary outcome...
November 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29144772/subchondral-bone-degradation-after-microfracture-for-osteochondral-lesions-of-the-talus-an-mri-analysis
#8
Yoshiharu Shimozono, Max Coale, Youichi Yasui, Amanda O'Halloran, Timothy W Deyer, John G Kennedy
BACKGROUND: Microfracture is the most common cartilage-reparative procedure for the treatment of osteochondral lesions of the talus (OLTs). Damage to the subchondral bone (SCB) during microfracture may irreversibly change the joint-loading support of the ankle, leading to reparative fibrocartilage degradation over time. PURPOSE: To investigate the morphological change in the SCB after microfracture for OLT by developing a novel magnetic resonance imaging (MRI) scoring system specifically for evaluating the SCB...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29126038/magnetic-resonance-imaging-findings-of-chronic-plantar-fasciitis-before-and-after-extracorporeal-shock-wave-therapy
#9
Masahiro Maki, Kazuya Ikoma, Masamitsu Kido, Yusuke Hara, Koshiro Sawada, Suzuyo Ohashi, Toshikazu Kubo
INTRODUCTION: The objective of this study is to examine the relationships between treatment outcome and changes in magnetic resonance (MR) imaging findings after extracorporeal shock wave therapy (ESWT) for chronic plantar fasciitis. METHODS: The subjects were 23 feet of 23 patients of refractory plantar fasciitis. The mean age was 53.7 years. The thickness of the plantar fascia (PF) and findings of a high-signal intensity area (HSIA) inside the PF, edema around the PF, and bone marrow edema (BME) of the calcaneus were investigated on MR images...
December 2017: Foot
https://www.readbyqxmd.com/read/29113363/involvement-of-inducible-nitric-oxide-synthase-and-mitochondrial-dysfunction-in-the-pathogenesis-of-enterovirus-71-infection
#10
Dejian Dang, Chao Zhang, Rongguang Zhang, Weidong Wu, Shuaiyin Chen, Jingchao Ren, Peng Zhang, Guangyuan Zhou, Demin Feng, Tiantian Sun, Ying Li, Qiaoli Liu, Mengchen Li, Yuanlin Xi, Yuefei Jin, Guangcai Duan
Enterovirus71 (EV71) is recognized as the main causative agent of severe hand, foot and mouth disease (HFMD). However, the pathogenesis of EV71 infection has not been well characterized. Clinical evidence indicated that inducible nitric oxide synthase (iNOS) induction in the lung of HFMD patients contributes to the severe symptoms of pulmonary edema. In the present study, we recruited 142 subjects including HFMD patients and controls, and serum level of nitric oxide (NO) was determined. Next, cellular and animal model were used to further investigate the roles of iNOS and mitochondria damage during EV71 infection...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108321/association-study-of-inflammatory-cytokine-and-chemokine-expression-in-hand-foot-and-mouth-disease
#11
Wenzhong Shang, Suying Qian, Lijuan Fang, Yong Han, Cuiping Zheng
Objective: To determine the relationship of cytokine/chemokine expression with the clinical presentation of hand, foot and mouth disease (HFMD). Results: All cytokine/chemokine levels were higher in severe HFMD patients than in mild HFMD patients or controls (P < 0.01). RANTES, MCP-1, IL-4, IL-12 and IL-18 levels were higher in mild HFMD patients than in the controls (P < 0.05). In severe HFMD, all levels (except IL-8 and IL-4) were higher in patients with encephalitis plus pulmonary edema than in those with encephalitis alone (P < 0...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049234/case-report-features-of-hand-foot-and-mouth-disease-in-neonates
#12
Wen-Wen Chen, Zhao-Bin Yang, Lian-Shu Lian, Li-Ping Xu
RATIONALE: Hand, foot and mouth disease (HFMD) is caused by enterovirus. The virus may exist in secretions. PATIENT CONCERNS: Five neonates had symptoms of fever and maculopapular rashes involving face, trunk, breech, arms, and legs, especially scattering on palms and feet. Blood, oropharyngeal fluid, urine, and cerebrospinal fluid (CSF) samples were collected and detected for further diagnoses with the consent of the infants' parents. Some of them suffered aseptic meningitis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28970089/risk-factors-for-neurogenic-pulmonary-edema-in-patients-with-severe-hand-foot-and-mouth-disease-a-meta-analysis
#13
Lijun Peng, Ruping Luo, Zhisheng Jiang
OBJECTIVE: To investigate the risk factors for neurogenic pulmonary edema (NPE) in patients with severe hand, foot, and mouth disease (HFMD) and to provide evidence for the prevention and treatment of NPE. METHODS: Several databases were searched (from inception to 2017) to identify case-control studies on risk factors for NPE among patients with severe HFMD. Data were analyzed via meta-analysis. The combined odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed-effects and random-effects models, and a sensitivity analysis and evaluation of publication bias was also performed...
September 29, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28959829/-research-progress-on-pharmacological-action-and-clinical-application-of-stephania-tetrandrae-radix
#14
REVIEW
Rong Wang, Teng-Mao Ma, Fei Liu, Hui-Qin Gao
Stephania Tetrandrae Radix is one of the common traditional Chinese medicines, which has bitter and pungent taste as well as cold properties. It can subside edema, get rid of rheumatism and relieve pain. Therefore, it is mainly used for the treatment of rheumatism arthralgia, edema, dysuria, athlete's foot, swollen wet sores and other diseases in traditional Chinese medicine(TCM). Stephania Tetrandrae Radix is mainly composed of dual-benzyl isoquinoline alkaloids, including tetrandrine, fangchinoline and so on...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28932317/ventral-abdominal-hernia
#15
Georgi Tchernev, Anastasiya Chokoeva, Jacopo Lotti, Katlein França, Torello Lotti
A 63-year-old Caucasian female patient presented with redness of the both foot and lower legs, as well as edema of the left lower leg, accompanied by subjective complaints of burning. Fever was not reported. Well-circumscribed oval shaped tumor formation was revealed also on the abdominal wall, with hyperpigmented and depigmented areas on its ulcerated surface, measuring approximately 10/10cm in diameter, with soft-elastic texture on palpation. The lesion occurred in 2011, according to the patient's history...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28931688/a-selective-bottleneck-shapes-the-evolutionary-mutant-spectra-of-enterovirus-a71-during-viral-dissemination-in-humans
#16
Sheng-Wen Huang, Yi-Hui Huang, Huey-Pin Tsai, Pin-Hwa Kuo, Shih-Min Wang, Ching-Chuan Liu, Jen-Ren Wang
RNA viruses accumulate mutations to rapidly adapt to environmental changes. Enterovirus A71 (EV-A71) causes various clinical manifestations with occasional severe neurological complications. However, the mechanism by which EV-A71 evolves within the human body is unclear. Utilizing deep sequencing and haplotype analyses of viruses from various tissues of an autopsy patient, we sought to define the evolutionary pathway by which enterovirus A71 evolves fitness for invading the central nervous system in humans...
December 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28917976/low-molecular-weight-fucoidan-ameliorates-hindlimb-ischemic-injury-in-type-2-diabetic-rats
#17
Zhiqiang Wang, Tiantian Liu, Xiaoping Chen, Hongjie You, Quanbin Zhang, Jingyi Xue, Yuanyuan Zheng, Dali Luo
ETHNOPHARMACOLOGICAL RELEVANCE: Low molecular weight fucoidan (LMWF), extracted from Laminaria japonica Areschoug, is a traditional Chinese medicine, commonly used to alleviate edema, particularly for feet with numbness and pain. AIM OF THE STUDY: Diabetic mellitus (DM) patients are at high risk of developing peripheral arterial disease (PAD). Individuals with DM and PAD co-morbidity have a much higher risk of critical limb ischemia. LMWF showed several beneficial effects, such as anti-inflammation, anti-thrombosis, and enhancing revascularization...
September 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28882666/clinical-features-for-89-deaths-of-hand-foot-and-mouth-disease-in-guangxi-china-2014
#18
Wei Lin, Ying Su, Min Jiang, Jing Liu, Yan-Yan Zhang, Guang-Min Nong
OBJECTIVES: The aim of this study is to summarize the risk factors of severe Hand, foot and mouth disease (HFMD) and explore the clinical characteristics of pulmonary edema (PE) and non-PE in the deceased patients with HFMD. METHODS: We identified 89 HFMD deaths which were separated into the PE group or non-PE group. Next, patients were divided based on their initial admission to hospitals as stage 1, 2, 3, or 4; at this point, their clinical manifestations were compared...
September 4, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28880750/effects-of-aqua-lymphatic-therapy-on-lower-extremity-lymphedema-a-randomized-controlled-study
#19
Gulbin Ergin, Didem Karadibak, Hulya Ozlem Sener, Baris Gurpinar
BACKGROUND: The purpose of this study is to investigate the effects of the aqua-lymphatic therapy (ALT) on unilateral lower extremity lymphedema in the maintenance phase. MATERIALS AND METHODS: This is a randomized controlled trial with a blinded assessor. The study was completed with 30 ALT and 27 control group participants. Foot volume was assessed by a water displacement device, limb volume by circumference measurements, functional capacity by a 6-minute walk test, quality of life by Short Form-36, and social appearance by Social Appearance Anxiety Scale and hopeless by Beck Hopeless Scale...
September 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28842354/fatal-stroke-after-bothrops-snakebite-in-the-amazonas-state-brazil-a-case-report
#20
Sâmella Silva de Oliveira, Luciana Aparecida Freitas-de-Sousa, Eliane Campos Alves, Luiz Carlos de Lima Ferreira, Iran Mendonça da Silva, Marcus Vinícius Guimarães de Lacerda, Hui Wen Fan, Ana Maria Moura-da-Silva, Wuelton Marcelo Monteiro
Bothrops atrox is the snake responsible for the majority of snakebites in the Brazilian Amazon. Patients generally evolve to local manifestations such as edema, pain and ecchymoses. Systemic effects of B. atrox venom are usually restricted to blood incoagulability and spontaneous bleeding. However, in a few cases, bleeding in the central nervous system may occur, which can lead to sequels and deaths. Here, we report a case of a 59 year-old woman who presented edema, pain and ecchymoses on the right foot, headache, nausea, diarrhea, hypertension and blood incoagulability after the bite by Bothrops snake in the Brazilian Amazon...
November 2017: Toxicon: Official Journal of the International Society on Toxinology
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