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https://www.readbyqxmd.com/read/29163029/micrornas-and-target-genes-as-biomarkers-for-the-diagnosis-of-early-onset-of-parkinson-disease
#1
REVIEW
Ahmad R Arshad, Siti A Sulaiman, Amalia A Saperi, Rahman Jamal, Norlinah Mohamed Ibrahim, Nor Azian Abdul Murad
Among the neurodegenerative disorders, Parkinson's disease (PD) ranks as the second most common disorder with a higher prevalence in individuals aged over 60 years old. Younger individuals may also be affected with PD which is known as early onset PD (EOPD). Despite similarities between the characteristics of EOPD and late onset PD (LODP), EOPD patients experience much longer disease manifestations and poorer quality of life. Although some individuals are more prone to have EOPD due to certain genetic alterations, the molecular mechanisms that differentiate between EOPD and LOPD remains unclear...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29160472/technical-nursing-students-interacting-with-family-members-of-hospitalized-children
#2
Juliana Yukari Takahashi Onishi, Circéa Amália Ribeiro, Maria Cristina Ferreira Carlos Rodrigues da Silva, Regina Issuzu Hirooka de Borba
OBJECTIVE: To understand technical nursing students' meaning of interacting with family members of hospitalized children. METHOD: Symbolic Interactionism was used as the theoretical framework and Qualitative Content Analysis was the methodological procedure. A total of eight graduates from an institution situated in the city of Osasco, Sao Paulo state, participated in this study. Data were collected through semi-structured interviews. RESULTS: A total of five representative themes were revealed: Dealing with difficult situations with family members; Perceiving oneself to be unprepared to interact with family members; Family members being a helpful tool; Developing strategies to obtain a good interaction with family members; and Teachers being facilitators of the interaction with family members...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29159934/ovarian-cancer-early-detection-by-circulating-ca125-in-the-context-of-anti-ca125-autoantibody-levels-results-from-the-epic-cohort
#3
Renée T Fortner, Helena Schock, Charlotte Le Cornet, Anika Hüsing, Allison F Vitonis, Theron S Johnson, Raina N Fichorova, Titilayo Fashemi, Hidemi S Yamamoto, Anne Tjønneland, Louise Hansen, Kim Overvad, Marie-Christine Boutron-Ruault, Marina Kvaskoff, Gianluca Severi, Heiner Boeing, Antonia Trichopoulou, Eleni-Maria Papatesta, Carlo La Vecchia, Domenico Palli, Sabina Sieri, Rosario Tumino, Carlotta Sacerdote, Amalia Mattiello, N Charlotte Onland-Moret, Petra H Peeters, H B As Bueno-de-Mesquita, Elisabete Weiderpass, J Ramón Quirós, Eric J Duell, Maria-Jose Sánchez, Carmen Navarro, Eva Ardanaz, Nerea Larrañaga, Björn Nodin, Karin Jirström, Annika Idahl, Eva Lundin, Kay-Tee Khaw, Ruth C Travis, Marc Gunter, Mattias Johansson, Laure Dossus, Melissa A Merritt, Elio Riboli, Kathryn L Terry, Daniel W Cramer, Rudolf Kaaks
CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non-cases. Anti-CA125 autoantibodies are observed in circulation. Our objective was to evaluate whether these antibodies (1) can serve as early detection markers, providing evidence of an immune response to a developing tumor, and (2) modify the discriminatory capacity of CA125 by either masking CA125 levels (resulting in lower discrimination) or acting synergistically to improve discrimination between cases and non-cases...
November 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29155675/enhancing-workforce-capacity-to-improve-vaccination-data-quality-uganda
#4
Kirsten Ward, Kevin Mugenyi, Amalia Benke, Henry Luzze, Carol Kyozira, Ampeire Immaculate, Patricia Tanifum, Annet Kisakye, Peter Bloland, Adam MacNeil
In Uganda, vaccine dose administration data are often not available or are of insufficient quality to optimally plan, monitor, and evaluate program performance. A collaboration of partners aimed to address these key issues by deploying data improvement teams (DITs) to improve data collection, management, analysis, and use in district health offices and health facilities. During November 2014-September 2016, DITs visited all districts and 89% of health facilities in Uganda. DITs identified gaps in awareness and processes, assessed accuracy of data, and provided on-the-job training to strengthen systems and improve healthcare workers' knowledge and skills in data quality...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29152839/beta-cell-sensitivity-to-glucose-is-impaired-after-gastric-bypass-surgery
#5
Marzieh Salehi, Amalia Gastaldelli, David A D'Alessio
AIMS: Patients with Roux-en-Y gastric bypass surgery (GB) have exaggerated postprandial insulin secretion, which has been attributed to increased meal glucose appearance and enhanced incretin effect. Here we sought to determine β-cell glucose sensitivity in the absence of meal stimulation and insulinotropic gut factors. MATERIALS AND METHODS: Twelve non-diabetic subjects with prior GB, and 7 matched non-surgical controls with normal glucose tolerance were studied...
November 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29149836/are-there-different-kinds-of-aging
#6
Amalia Gabriela Diaconeasa
A critical analysis of the accelerated aging syndromes may explain what aging is, but also why some tissues and organs age at accelerated rates in comparison with aging rates of other tissues. Syndromes of accelerated aging are caused by mutations affecting the integrity of the genetic material. Among them, the most studied is Werner's syndrome, "adult progeria", caused by a recessive autosomal mutation with a frequency of 1 in 10 millions, which affects a helicase involved in DNA repair. In Werner syndrome, there is a loss of heterochromatin, though the stability of heterochromatin is also affected in "normal" aging...
November 16, 2017: Current Aging Science
https://www.readbyqxmd.com/read/29149041/the-hmga1-pseudogene-7-induces-mir-483-and-mir-675-upregulation-by-activating-egr1-through-a-cerna-mechanism
#7
Marco De Martino, Giuseppe Palma, Amalia Azzariti, Claudio Arra, Alfredo Fusco, Francesco Esposito
Several studies have established that pseudogene mRNAs can work as competing endogenous RNAs and, when deregulated, play a key role in the onset of human neoplasias. Recently, we have isolated two HMGA1 pseudogenes, HMGA1P6 and HMGA1P7. These pseudogenes have a critical role in cancer progression, acting as micro RNA (miRNA) sponges for HMGA1 and other cancer-related genes. HMGA1 pseudogenes were found overexpressed in several human carcinomas, and their expression levels positively correlate with an advanced cancer stage and a poor prognosis...
November 17, 2017: Genes
https://www.readbyqxmd.com/read/29147966/polyamine-concentration-is-increased-in-thoracic-ascending-aorta-of-patients-with-bicuspid-aortic-valve
#8
Amalia Forte, Mario Grossi, Ciro Bancone, Marilena Cipollaro, Marisa De Feo, Per Hellstrand, Lo Persson, Bengt-Olof Nilsson, Alessandro Della Corte
Polyamines are cationic molecules synthesized via a highly regulated pathway, obtained from the diet or produced by the gut microbiota. They are involved in general molecular and cellular phenomena that play a role also in vascular disease. Bicuspid aortic valve (BAV) is a congenital malformation associated to a greater risk of thoracic ascending aorta (TAA) aneurysm, whose pathogenesis is not yet well understood. We focused on differential analysis of key members of polyamine pathway and on polyamine concentration in non-dilated TAA samples from patients with either stenotic tricuspid aortic valve (TAV) or BAV (diameter ≤ 45 mm), vs...
November 17, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29140880/high-risk-human-papillomavirus-determination-in-formalin-fixed-paraffin-embedded-cervical-tissue-using-the-roche-cobas-4800-system-a-comparative-study-with-liquid-based-cytology
#9
Juan C Tardío, Olivia Cambero, Carolina Sánchez-Estévez, Ana B Sánchez-García, Fernando Angulo, Amalia Moreno
Roche cobas 4800 human papillomavirus (HPV) test is an automated real-time polymerase chain reaction-based system that allows the simultaneous detection of 14 human papillomavirus high-risk (HR-HPV) genotypes. This test is Food and Drug Administration approved since 2011 for HPV determination in liquid-based cytologic samples, but a clinically validated technique for formalin-fixed, paraffin-embedded (FFPE) tissue specimens is presently not commercially available. In our laboratory, we have developed an HPV detection procedure in FFPE tissue by cobas 4800 HPV test...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29128264/coupling-astogenic-aging-in-the-colonial-tunicate-botryllus-schlosseri-with-the-stress-protein-mortalin
#10
Oshrat Ben-Hamo, Amalia Rosner, Claudette Rabinowitz, Matan Oren, Baruch Rinkevich
Botryllus schlosseri, a colonial marine invertebrate, exhibits three generations of short-lived astogenic modules that continuously grow and die throughout the colony's entire lifespan, within week-long repeating budding cycles (blastogenesis), each consisting of four stages (A-D). At stage D, aging is followed by the complete absorption of adult modules (zooids) via a massive apoptotic process. Here we studied in Botryllus the protein mortalin (HSP70s member), a molecule largely known for its association with aging and proliferation...
November 8, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29126019/a-set-of-biogenetically-interesting-polyhalogenated-acetogenins-from-ptilonia-magellanica
#11
Amalia B Gallardo, Mercedes Cueto, Ana R Díaz-Marrero, José M de la Rosa, Victor Fajardo, Aurelio San-Martín, José Darias
Ptilonines A-F, pyranosylmagellanicus D-E and magellenediol are previously undescribed acetogenins isolated from the red alga Ptilonia magellanica. Their structures were determined from spectroscopic evidence. The absolute configuration of the known pyranosylmagellanicus A, was established by derivatization with (R)- and (S)-α-methoxy -α-phenylacetic acids (MPA). Ptilonines exhibit an unusual halogenation pattern, that may confer evolutionary advantages to Ptilonia magellanica, for which a biogenetic origin is proposed...
November 7, 2017: Phytochemistry
https://www.readbyqxmd.com/read/29115233/a-call-for-planetary-health-case-studies
#12
Sara B Stone, Amalia A Almada, Samuel S Myers
No abstract text is available yet for this article.
November 4, 2017: Lancet
https://www.readbyqxmd.com/read/29109303/insulin-resistance-and-reduced-metabolic-flexibility-cause-or-consequence-of-nafld
#13
EDITORIAL
Amalia Gastaldelli
Whether non-alcoholic fatty liver disease (NAFLD) precedes insulin resistance (IR) or IR preludes/causes NAFLD has been long debated. Recent studies have shown that there are two phenotypes of NAFLD, 'genetic' vs 'metabolic' NAFLD. The former patients are more at risk of hepatocellular carcinoma and chronic liver disease the latter are more IR and at increased risk of type 2 diabetes (T2D). Even if they are not yet diabetics, from a metabolic point of view having NAFLD is equivalent to T2D with reduced peripheral glucose disposal and impaired suppression of hepatic glucose production, but without fasting hyperglycaemia...
November 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29102936/the-human-mesenchymal-stem-cells-and-the-chick-embryo-chorioallantoic-membrane-the-key-and-the-lock-in-revealing-vasculogenesis
#14
Şerban Comşa, Raluca Amalia Ceaușu, Roxana Popescu, Anca Maria Cîmpean, Marius Raica
BACKGROUND/AIM: To analyze the interaction between the human mesenchymal stem cells (hMSC) and the chick embryo chorioallantoic membrane (CAM), in order to assess the still obscure process of vasculogenesis. MATERIALS AND METHODS: We implanted hMSC onto CAM and we analyzed the morphology and the immunohistochemical profile of CAM. RESULTS: hMSC adhered to CAM, few of them entered the chorionic epithelium and the mesoderm and developed a CD44(-)/Ki67(-) status...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29101151/laser-scanning-in-vivo-confocal-microscopy-ivcm-for-evaluating-human-corneal-sub-basal-nerve-plexus-parameters-protocol-for-a-systematic-review
#15
Manikkuwadura Eranda Harshan De Silva, Alexis Ceecee Zhang, Amalia Karahalios, Holly Rose Chinnery, Laura Elizabeth Downie
INTRODUCTION: Laser scanning in vivo confocal microscopy (IVCM) enables non-invasive, high-resolution imaging of the cornea. In recent years, there has been a vast increase in researchers using laser scanning IVCM to image and quantify corneal nerve parameters. However, a range of methodological approaches have been adopted. The primary aim of this systematic review is to critically appraise the reported method(s) of primary research studies that have used laser scanning IVCM to quantify corneal sub-basal nerve plexus (SBNP) parameters in humans, and to examine corneal nerve parameters in healthy individuals...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29076132/moderate-to-late-preterm-intrauterine-growth-restriction-a-restrospective-observational-study-of-the-indications-for-delivery-and-outcomes-in-an-australian-perinatal-centre
#16
Bridie Stewart, Amalia Karahalios, Rosalynn Pszczola, Joanne Said
BACKGROUND: The management of preterm intrauterine growth restriction is limited to fetal surveillance and timely delivery. Despite the existence of evidence-based guidelines, uncertainty regarding the optimal timing of delivery is common, and management remains individualised for each patient. AIMS: To provide recent Australian data on the indications for delivery of moderate to late preterm growth restricted infants and the outcomes of these deliveries. MATERIALS AND METHODS: Retrospective study of singleton live births delivered between 32 + 0 and 36 + 6 weeks gestation over a three-year period (2012-2014) at a Melbourne Metropolitan Hospital...
October 27, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29073980/the-undiagnosed-pandemic-burnout-and-depression-within-the-surgical-community
#17
Lauren DeCaporale-Ryan, Joseph V Sakran, Scott B Grant, Adnan Alseidi, Tziporah Rosenberg, Ross F Goldberg, Hilary Sanfey, Joseph Dubose, Stanislaw Stawicki, Robert Ricca, Ellen Thomason Derrick, Carol A Bernstein, Dinchen A Jardine, Amalia J Stefanou, Ben Aziz, Ellie He, Sharmila Dissanaike, Col Gerald R Fortuna, Rodolfo J Oviedo, Jo Shapiro, Pamela Galowitz, Jacob Moalem
No abstract text is available yet for this article.
September 2017: Current Problems in Surgery
https://www.readbyqxmd.com/read/29069623/the-effect-of-impaired-verbal-memory-retrieval-on-autobiographical-memory-across-different-life-periods-in-schizophrenia
#18
Amalia Alexiadou, Vasilis P Bozikas, Mary H Kosmidis, Eleni Parlapani, Grigoris Kiosseoglou, Konstantinos Fokas
OBJECTIVES: Autobiographical memory (AM) involves recollection of personal events and facts about one's life. Αim of the present study was to investigate AM in schizophrenia patients, and, in particular, patients' ability to recall autobiographical memories after controlling for verbal memory and verbal fluency deficits. METHOD: Participants included 40 schizophrenia patients (23 male) and 40 healthy controls (23 male), matched for age, gender, educational level, and premorbid intellectual functioning...
September 12, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29069083/rhogef9-splice-isoforms-influence-neuronal-maturation-and-synapse-formation-downstream-of-%C3%AE-2-gabaa-receptors
#19
Claire de Groot, Amalia Floriou-Servou, Yuan-Chen Tsai, Simon Früh, Manuela Kohler, Georgia Parkin, Cornelia Schwerdel, Giovanna Bosshard, Kai Kaila, Jean-Marc Fritschy, Shiva K Tyagarajan
In developing brain neuronal migration, dendrite outgrowth and dendritic spine outgrowth are controlled by Cdc42, a small GTPase of the Rho family, and its activators. Cdc42 function in promoting actin polymerization is crucial for glutamatergic synapse regulation. Here, we focus on GABAergic synapse-specific activator of Cdc42, collybistin (CB) and examine functional differences between its splice isoforms CB1 and CB2. We report that CB1 and CB2 differentially regulate GABAergic synapse formation in vitro along proximal-distal axis and adult-born neuron maturation in vivo...
October 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29067765/identification-of-the-molecular-determinants-of-the-antibacterial-activity-of-lmuttx-a-lys49-phospholipase-a2-homologue-isolated-from-lachesis-muta-muta-snake-venom-linnaeus-1766
#20
Rafaela Diniz-Sousa, Cleópatra A S Caldeira, Anderson M Kayano, Mauro V Paloschi, Daniel C Pimenta, Rodrigo Simões-Silva, Amália S Ferreira, Fernando B Zanchi, Najla B Matos, Fernando P Grabner, Leonardo A Calderon, Juliana P Zuliani, Andreimar M Soares
Snake venom phospholipases A2 (PLA2 s) are responsible for numerous pathophysiological effects in snakebites; however, their biochemical properties favour antimicrobial actions against different pathogens, thus constituting a true source of potential microbicidal agents. This study describes the isolation of a Lys49 PLA2 homologue from Lachesis muta muta venom using two chromatographic steps: Size Exclusion and Reverse Phase. The protein showed a molecular mass of 13,889 Da and was devoid of phospholipase activity on an artificial substrate...
October 25, 2017: Basic & Clinical Pharmacology & Toxicology
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