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https://www.readbyqxmd.com/read/28089880/a-combined-approach-for-enhancing-the-stability-of-recombinant-cis-dihydrodiol-naphthalene-dehydrogenase-from-pseudomonas-putida-g7-allowed-for-the-structural-and-kinetic-characterization-of-the-enzyme
#1
Débora Maria Abrantes Costa, Mariana Amalia Figueiredo Costa, Samuel Leite Guimarães, Juliana Barbosa Coitinho, Stefanya Velásquez Gómez, Tiago Antônio da Silva Brandão, Ronaldo Alves Pinto Nagem
The second enzyme of the naphthalene degradation pathway in Pseudomonas putida G7 is NahB, a dehydrogenase that converts cis-1,2-dihydroxy-1,2-dihydronaphthalene to 1,2-dihydroxynaphthalene. We report the cloning, optimization of expression, purification, kinetic studies and preliminary structural characterization of the recombinant NahB. The nahB gene was cloned into a T7 expression vector and the enzyme was overexpressed in Escherichia coli Rosetta (DE3) as an N-terminal hexa-histidine-tagged protein (6xHis-NahB)...
January 9, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28088872/prognostic-prediction-by-liver-tissue-proteomic-profiling-in-patients-with-colorectal-liver-metastases
#2
Adalgiza Reyes, Josep Marti, Santiago Marfà, Wladimiro Jiménez, Vedrana Reichenbach, Amalia Pelegrina, Constantino Fondevila, Juan Carlos Garcia Valdecasas, Josep Fuster
AIM: To obtain proteomic profiles in patients with colorectal liver metastases (CRLM) and identify the relationship between profiles and the prognosis of CRLM patients. MATERIALS & METHODS: Prognosis prediction (favorable or unfavorable according to Fong's score) by a classification and regression tree algorithm of surface-enhanced laser desorption/ionization TOF-MS proteomic profiles from cryopreserved CRLM (patients) and normal liver tissue (controls). RESULTS: The protein peak 7371 m/z showed the clearest differences between CRLM and control groups (94...
January 16, 2017: Future Oncology
https://www.readbyqxmd.com/read/28067244/corrigendum-premature-changes-in-neuronal-excitability-account-for-hippocampal-network-impairment-and-autistic-like-behavior-in-neonatal-btbr-t-tf-j-mice
#3
Giada Cellot, Laura Maggi, Maria Amalia Di Castro, Myriam Catalano, Rosanna Migliore, Michele Migliore, Maria Luisa Scattoni, Gemma Calamandrei, Enrico Cherubini
No abstract text is available yet for this article.
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28056491/propranolol-as-first-line-treatment-for-life-threatening-diffuse-infantile-hepatic-hemangioma-a-case-report
#4
Giulia Varrasso, Amalia Schiavetti, Silvia Lanciotti, Maria Sapio, Eva Ferrara, Alessandra De Grazia, And Anna Clerico
No abstract text is available yet for this article.
January 5, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28052966/role-of-adipose-tissue-insulin-resistance-in-the-natural-history-of-t2dm-results-from-the-san-antonio-metabolism-study
#5
Amalia Gastaldelli, Melania Gaggini, Ralph A DeFronzo
In the transition from normal glucose tolerance (NGT) to type 2 diabetes mellitus (T2DM), the role of β-cell dysfunction and peripheral insulin resistance (IR) is well established. However, the impact of dysfunctional adipose tissue has not been fully elucidated. The aim of the present study is to evaluate the role of resistance to the antilipolytic effect of insulin (Adipo-IR) in a large group of NGT, IGT and T2DM subjects.302 subjects with varying glucose tolerance received OGTT and euglycemic insulin clamp...
January 4, 2017: Diabetes
https://www.readbyqxmd.com/read/28050719/sudden-benzodiazepine-induced-resolution-of-post-operative-pediatric-cerebellar-mutism-syndrome-a-clinical-spect-study
#6
Francesco Nicita, Milena Paiano, Mauro Liberatore, Alberto Spalice, Paola Papoff, Mariacristina Ullo, Manolo Piccirilli, Anna Clerico, Amalia Schiavetti
Post-operative pediatric cerebellar mutism syndrome (PPCMS) is a clinical syndrome arising from cerebellar injury and characterized by absence of speech and other possible symptoms and signs. Rare reports described some benefit after administration of dopamine agonist therapy, but no treatment has proven efficacy. In this paper, we report on the dramatic, sudden resolution of PPCMS induced by midazolam administration in a boy who underwent posterior fossa surgery for choroid plexus papilloma of the fourth ventricle...
January 3, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28025020/epigenetic-and-genetic-variants-in-the-htr1b-gene-and-clinical-improvement-in-children-and-adolescents-treated-with-fluoxetine
#7
Patricia Gassó, Natalia Rodríguez, Ana Blázquez, Ana Monteagudo, Daniel Boloc, Maria Teresa Plana, Amalia Lafuente, Luisa Lázaro, Joan Albert Arnaiz, Sergi Mas
The serotonin 1B receptor (5-HT1B) is important to both the pathogenesis of major depressive disorder and the antidepressant effects of selective serotonin reuptake inhibitors. Although fluoxetine has been shown to be effective and safe in children and adolescents, not all patients experience a proper clinical response, which has led to further study into the main factors involved in this inter-individual variability. Our aim was to study the effect of epigenetic and genetic factors that could affect 5-hydroxytryptamine receptor 1B (HTR1B) gene expression, and thereby response to fluoxetine...
December 23, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28012856/increased-fndc5-irisin-expression-in-human-hepatocellular-carcinoma
#8
Melania Gaggini, Manuela Cabiati, Serena Del Turco, Teresa Navarra, Paolo De Simone, Franco Filipponi, Silvia Del Ry, Amalia Gastaldelli, Giuseppina Basta
The fibronectin type III domain containing 5 (FNDC5)/Irisin, a novel energy-regulating hormone, is associated with lipid and carbohydrate metabolism. It is produced in low amounts by normal hepatic tissue, while in human hepatocellular carcinoma (HCC), in which aberrant de novo lipogenesis (DNL) occurs, the hepatic expression of FNDC5/Irisin is still unknown. The gene expression of FNDC5/Irisin, associated to key regulators of DNL, inflammation and cancer progression was evaluated in liver tissue of 18 patients with HCC undergoing liver transplantation and of 18 deceased donors...
December 21, 2016: Peptides
https://www.readbyqxmd.com/read/28011720/exploiting-the-great-potential-of-sequence-capture-data-by-a-new-tool-super-cap
#9
Valentino Ruggieri, Irantzu Anzar, Andreu Paytuvi, Roberta Calafiore, Riccardo Aiese Cigliano, Walter Sanseverino, Amalia Barone
The recent development of Sequence Capture methodology represents a powerful strategy for enhancing data generation to assess genetic variation of targeted genomic regions. Here, we present SUPER-CAP, a bioinformatics web tool aimed at handling Sequence Capture data, fine calculating the allele frequency of variations and building genotype-specific sequence of captured genes. The dataset used to develop this in silico strategy consists of 378 loci and related regulative regions in a collection of 44 tomato landraces...
December 22, 2016: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28002972/response-to-drug-therapy-for-ectopic-fat-myth-or-reality
#10
Amalia Gastaldelli, Melania Gaggini
No abstract text is available yet for this article.
December 26, 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27997653/effect-of-pritelivir-compared-with-valacyclovir-on-genital-hsv-2-shedding-in-patients-with-frequent-recurrences-a-randomized-clinical-trial
#11
Anna Wald, Burkhard Timmler, Amalia Magaret, Terri Warren, Stephen Tyring, Christine Johnston, Kenneth Fife, Stacy Selke, Meei-Li Huang, Hans-Peter Stobernack, Holger Zimmermann, Lawrence Corey, Alexander Birkmann, Helga Ruebsamen-Schaeff
Importance: Current therapy of herpes infections relies on nucleoside analogues. Pritelivir is a well-tolerated novel herpes simplex virus (HSV) helicase-primase inhibitor that reduced genital shedding and lesions. Objective: To compare the efficacy of pritelivir with valacyclovir for suppression of genital HSV-2 infection. Design, Setting, and Participants: A phase 2, randomized, double-blind, crossover clinical trial at clinical research centers in 4 US cities (October 2012-July 2013) compared daily oral doses of 100 mg of pritelivir with 500 mg of valacyclovir...
20, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27989397/masticatory-function-parameters-in-patients-with-varying-degree-of-mandibular-bone-resorption
#12
Raissa Micaella Marcello-Machado, Amália Machado Bielemann, Gustavo Giacomelli Nascimento, Luciana de Rezende Pinto, Altair Antoninha Del Bel Cury, Fernanda Faot
PURPOSE: This cross-sectional study analyzes how bone resorption affects the masticatory function and investigates the relation between perceived and measured masticatory function. METHODS: Thirty complete dentures wearers were divided in two groups according to mandible bone atrophy based on the classification criteria from Cawood & Howell. Retention and stability of the mandibular complete denture, masticatory performance (MP) indexes (X_50 and B) and masticatory efficiency (ME, sieves 4 and 2...
December 15, 2016: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/27987391/fast-screening-of-tissue-samples-for-glycogen
#13
Raluca-Ioana Stefan-van Staden, Amalia Gabriela Diaconeasa, Camelia Stanciu-Gavan
Screening of tissue samples for glycogen is very important in assessing the ageing, but also the state of health of the tissue. Therefore, two needle stochastic sensors based on maltodextrins presenting different dextrose equivalence (DE) MD-m (DE 13.0-17.0), and MD-M (DE 16.5-19.5) immobilized in diamond paste (obtained from synthetic diamond and paraffin oil) were designed and characterized. These stochastic sensors were used reliable for both qualitative and quantitative analysis for the assay of glycogen in tissue samples with limits of determination as low as 1fmol L(-1)...
December 8, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27984413/gamma-glutamyltransferase-fatty-liver-index-and-hepatic-insulin-resistance-are-associated-with-incident-hypertension-in-two-longitudinal-studies
#14
Fabrice Bonnet, Amalia Gastaldelli, Florence Pihan-Le Bars, Andrea Natali, Ronan Roussel, John Petrie, Jean Tichet, Michel Marre, Bernard Fromenty, Beverley Balkau
OBJECTIVE: We hypothesized that liver markers and the fatty liver index (FLI) are predictive of incident hypertension and that hepatic insulin resistance plays a role. METHODS: The association between liver markers and incident hypertension was analysed in two longitudinal studies of normotensive individuals, 2565 from the 9-year data from an epidemiological study on the insulin resistance cohort and the 321 from the 3-year 'Relationship between Insulin Sensitivity and Cardiovascular disease' cohort who had a measure of endogenous glucose production...
December 14, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27983628/the-effects-of-annatto-tocotrienol-on-bone-biomechanical-strength-and-bone-calcium-content-in-an-animal-model-of-osteoporosis-due-to-testosterone-deficiency
#15
Kok-Yong Chin, Dhivakaran Gengatharan, Fadlin Sakina Mohd Nasru, Rehan Amalia Khairussam, Sherlyn Lai Hui Ern, Siti Aina Wahidah Aminuddin, Soelaiman Ima-Nirwana
Osteoporosis reduces the skeletal strength and increases the risk for fracture. It is an underdiagnosed disease in men. Annatto tocotrienol has been shown to improve bone structural indices and increase expression of bone formation genes in orchidectomized rats. This study aimed to evaluate the effects of annatto tocotrienol on biomechanical strength and calcium content of the bone in orchidectomized rats. Thirty three-month-old male Sprague-Dawley rats were randomly assigned to five groups. The baseline control (BC) group was sacrificed at the onset of the study...
December 14, 2016: Nutrients
https://www.readbyqxmd.com/read/27982351/surgical-treatment-for-thrombus-straddling-a-patent-foramen-ovale
#16
Marcos Aurélio Barboza de Oliveira, Amália Tieco da Rocha Sabbag, Antônio Carlos Brandi, Carlos Alberto Dos Santos, Paulo Henrique Husseni Botelho, Franz Andrei Patriarcha, Domingo M Braile
We present a case of a 41-year-old female with deep vein thrombosis after abdominal surgery. The patient quickly developed severe pulmonary embolism and stroke representative of paradoxical embolism. Echocardiography showed a thrombus straddling a patent foramen ovale, which was confirmed intraoperatively. An accurate diagnosis and rapid treatment decisions are crucial for preventing patient deterioration in the form of new pulmonary embolisms or stroke.
September 2016: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27979245/formulation-of-yeast-leavened-bread-with-reduced-salt-content-by-using-a-lactobacillus-plantarum-fermentation-product
#17
Francesca Valerio, Amalia Conte, Mariaelena Di Biase, Veronica M T Lattanzio, S Lisa Lonigro, Lucia Padalino, Erica Pontonio, Paola Lavermicocca
A Lactobacillus plantarum fermentation product (Bio21B), obtained after strain growth (14h) in a wheat flour-based medium, was applied in the bread-making process as taste enhancer, in order to obtain a yeast-leavened bread with reduced salt content (20% and 50%) with respect to a reference bread (REF) not containing the fermentation product. Sensory analysis indicated that the Bio21B bread with salt reduced by 50% had a pleasant taste similar to the salt-containing bread (REF). l-Glutamate and total free amino acid content did not differ between REF and Bio21B breads, while the acids lactic, acetic, phenyllactic, 4-OH-phenyllactic and indole-3-lactic were present only in Bio21B breads...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27973438/pathophysiology-of-non-alcoholic-fatty-liver-disease
#18
REVIEW
Salvatore Petta, Amalia Gastaldelli, Eleni Rebelos, Elisabetta Bugianesi, Piergiorgio Messa, Luca Miele, Gianluca Svegliati-Baroni, Luca Valenti, Ferruccio Bonino
The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation...
December 11, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27968736/research-in-planetary-health-a-call-for-abstracts
#19
Samuel S Myers, Christopher D Golden, Amalia A Almada, Steven A Osofsky, Montira J Pongsiri
No abstract text is available yet for this article.
October 29, 2016: Lancet
https://www.readbyqxmd.com/read/27968727/effects-of-maternal-prenatal-stress-mechanisms-implications-and-novel-therapeutic-interventions
#20
Amalia Londono Tobon, Andrea Diaz Stransky, David A Ross, Hanna E Stevens
No abstract text is available yet for this article.
December 1, 2016: Biological Psychiatry
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