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https://www.readbyqxmd.com/read/29348426/one-protein-different-cell-fate-the-differential-outcome-of-depleting-grp75-during-oxidative-stress-in-neurons
#1
Birgit Honrath, Carsten Culmsee, Amalia M Dolga
No abstract text is available yet for this article.
January 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29345937/hole-hopping-rates-in-organic-semiconductors-a-second-order-cumulant-approach
#2
Alessandro Landi, Raffaele Borrelli, Amedeo Capobianco, Amalia Velardo, Andrea Peluso
Second-order cumulant expansion of the time dependent reduced density matrix has been employed to evaluate hole hopping rates in pentacene, tetracene, picene, and rubrene homodimers. The cumulant expansion is a full quantum mechanical approach, which allows to use in computations the whole set of nuclear coordinates of the system, including both the effects of the equilibrium position displacements and of normal mode mixing upon hole transfer. The time dependent populations predicted by cumulant approach are in good agreement with those obtained by numerical solution of time dependent Schrödinger equation, even for ultrafast processes, where the Fermi Golden Rule fails...
January 18, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29338678/supplementation-with-curcuma-longa-reverses-neurotoxic-and-behavioral-damage-in-models-of-alzheimer-s-disease-a-systematic-review
#3
Ianara Mendonca da Costa, Marco Aurelio de Moura Freire, Jose Rodolfo Lopes de Paiva Cavalcanti, Dayane Pessoa de Araujo, Bianca Norrara, Isleania Maria Marques Moreira Rosa, Eduardo Pereira de Azevedo, Amalia Cinthia Meneses do Rego, Irami Araujo Filho, Fausto Pierdona Guzen
BACKGROUND: The formation of senile plaques and neurofibrillary tangles of the tau protein are the main pathological mechanism of Alzheimer's disease (AD). Current therapies for AD offer discrete benefits to the clinical symptoms and do not prevent the continuing degeneration of neuronal cells. Therefore, novel therapeutic strategies have long been investigated, where curcumin (Curcuma longa) has shown some properties that can prevent the deleterious processes involved in neurodegenerative diseases...
January 16, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29332048/frequency-of-cardiovascular-genetic-risk-factors-in-a-calabrian-population-and-their-effects-on-dementia
#4
Raffaele Maletta, Nicoletta Smirne, Livia Bernardi, Maria Anfossi, Maura Gallo, Maria Elena Conidi, Rosanna Colao, Gianfranco Puccio, Sabrina A M Curcio, Valentina Laganà, Francesca Frangipane, Chiara Cupidi, Maria Mirabelli, Franca Vasso, Giusi Torchia, Maria G Muraca, Raffaele Di Lorenzo, Giuseppina Rose, Alberto Montesanto, Giuseppe Passarino, Amalia C Bruni
BACKGROUND: Several genetic variants playing a key role in cholesterol levels, blood pressure, and vascular dysfunction influence the risk of Alzheimer's disease (AD) and vascular dementia (VaD). The many meta-analysis studies carried out on large numbers of samples in different populations have not provided clear results to date, because a trans-ethnic shift of risk genotypes in different populations is often observed. OBJECTIVES: To determine genotypes allele frequencies of the polymorphisms most frequently identified to be correlated with cardio-cerebrovascular disease and AD in a Southern Italy population and to investigate their possible association with dementia...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29324758/settlement-and-post-settlement-survival-rates-of-the-white-seabream-diplodus-sargus-in-the-western-mediterranean-sea
#5
Amalia Cuadros, Gotzon Basterretxea, Luis Cardona, Adrien Cheminée, Manuel Hidalgo, Joan Moranta
Survival during the settlement window is a limiting variable for recruitment. The survival is believed to be strongly determined by biological interactions and sea conditions, however it has been poorly investigated. We examined the settlement patterns related to relevant biotic and abiotic factors (i.e. Density-dependence, wind stress, wave height and coastal current velocity) potentially determining post-settler survival rates of a coastal necto-benthic fish of wide distribution in the Mediterranean and eastern Atlantic, the white seabream (Diplodus sargus)...
2018: PloS One
https://www.readbyqxmd.com/read/29323721/brain-derived-neurotrophic-factor-modulates-cholesterol-homeostasis-and-apolipoprotein-e-synthesis-in-human-cell-models-of-astrocytes-and-neurons
#6
Maria Stefania Spagnuolo, Aldo Donizetti, Lucia Iannotta, Vincenza Aliperti, Chiara Cupidi, Amalia Cecilia Bruni, Luisa Cigliano
In the central nervous system, cholesterol is critical to maintain membrane plasticity, cellular function, and synaptic integrity. In recent years, much attention was focused on the role of cholesterol in brain since a breakdown of cholesterol metabolism has been associated with different diseases. Brain-derived neurotrophic factor (BDNF) was previously reported to elicit cholesterol biosynthesis and promote the accumulation of presynaptic proteins in cholesterol-rich lipid rafts, but no data are available on its ability to modulate physiological mechanisms involved in cholesterol homeostasis...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29318974/-understanding-the-role-of-hypoxia-inducible-factor-during-neurodegeneration-for-new-therapeutics-opportunities
#7
Amalia Merelli, Julio Cesar Garcia Rodriguez, Jaume Folch, Marcelo R Regueiro, Antoni Camins, Lazarowski Alberto
Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Several diseases affecting older individuals, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Parkinson's disease, stroke, Multiple Sclerosis and many others, are the most relevant disorders associated with NDG. Since other pathologies such as refractory epilepsy, brain infections, or hereditary diseases such as "neurodegeneration with brain iron accumulation", also lead to chronic brain inflammation with loss of neural cells, NDG can be said to affect all ages...
January 10, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29311015/tubular-aggregates-in-congenital-myasthenic-syndrome
#8
Amalia Feresiadou, Olivera Casar-Borota, Anca Dragomir, Carola Hedberg Oldfors, Erik Stålberg, Anders Oldfors
No abstract text is available yet for this article.
November 24, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29310656/comparative-evaluation-of-anopheline-sampling-methods-in-three-localities-in-indonesia
#9
Brandyce St Laurent, Supratman Sukowati, Timothy A Burton, David Bretz, Mulyadi Zio, Syah Firman, Sumardi, Heru Sudibyo, Amalia Safitri, Suwito, Puji B Asih, Sully Kosasih, Shinta, William A Hawley, Thomas R Burkot, Frank H Collins, Din Syafruddin, Neil F Lobo
BACKGROUND: The effectiveness of vector control efforts can vary based on the interventions used and local mosquito behaviour and adaptability. In many settings, biting patterns of Anopheles mosquitoes can shift in response to interventions targeting indoor-biting mosquitoes, often resulting in higher proportions of mosquitoes feeding outside or at times when people are not protected. These behaviourally resistant mosquitoes have been shown to sustain residual malaria transmission and limit control efforts...
January 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29300737/an-evaluation-of-hemoglobin-measurement-tools-and-their-accuracy-and-reliability-when-screening-for-child-anemia-in-rwanda-a-randomized-study
#10
Megan Parker, Zhen Han, Elizabeth Abu-Haydar, Eric Matsiko, Damien Iyakaremye, Lisine Tuyisenge, Amalia Magaret, Alexandre Lyambabaje
Blood hemoglobin (Hb) is a common indicator for diagnosing anemia and is often determined through laboratory analysis of venous samples. One alternative to laboratory-based methods is the handheld HemoCue® Hb 201+ device, which requires a finger prick and wicking of blood into a pretreated cuvette for analysis. An alternative HemoCue® gravity method is being investigated for improved accuracy. Further, recent developments in noninvasive technologies could provide an accurate, rapid, safe, point-of-care option for hemoglobin estimation while addressing some limitations of current tools, but device performance must be assessed in low-resource settings...
2018: PloS One
https://www.readbyqxmd.com/read/29299593/standardized-handoffs-in-the-intensive-care-unit-hope-or-hype-for-improving-critical-care
#11
Amalia Cochran
No abstract text is available yet for this article.
January 3, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29297565/prognostic-role-of-xtp1-depdc1b-and-sdp35-depdc1a-in-high-grade-soft-tissue-sarcomas
#12
Serena Pollino, Maria Serena Benassi, Laura Pazzaglia, Amalia Conti, Nicoletta Bertani, Alberto Righi, Martina Piccinni-Leopardi, Piero Picci, Roberto Perris
BACKGROUND: The outcome of patients with metastatic soft tissue sarcoma (STS) remains unfavourable and new therapeutic strategies are needed. The aim of this study was to determine the role of RhoGAP, XTP1/DEPDC1B and SDP35/DEPDC1A, as possible prognostic markers, to be used to identify candidate patients for more effective and personalized therapies. MATERIALS-METHODS: SDP35/DEPDC1A and XTP1/DEPDC1B transcriptional levels were evaluated by Real-Time PCR in 86 primary STS and 22 paired lung metastasis...
January 3, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29297227/a-protocol-for-the-incorporation-of-%C3%AE-amino-acids-into-peptides-application-to-shikimic-acid-based-2-amino-methylcyclohexanecarboxylic-acids
#13
Marcos A González, Amalia M Estévez, María Campos, Juan C Estévez, Ramon J Estevez
The first example of a new protocol for the incorporation of γ-amino acids into peptides is reported. It involved a shikimic acid based stereoselective synthesis polyhydroxylated-2-nitromethylcyclohexanecarboxylic acids, which were directly incorporated into peptides.
January 3, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29295478/bioactive-compounds-in-brassicaceae-vegetables-with-a-role-in-the-prevention-of-chronic-diseases
#14
REVIEW
Assunta Raiola, Angela Errico, Ganna Petruk, Daria Maria Monti, Amalia Barone, Maria Manuela Rigano
The beneficial role of the Mediterranean diet in the prevention of chronic diseases, including cardiovascular diseases, diabetes, and obesity, is well-recognized. In this context, Brassicaceae are considered important vegetables due to several evidences of their health promoting effects that are associated to bioactive compounds present in the edible parts of the plants. In this review, the mechanisms of action and the factors regulating the levels of the bioactive compounds in Brassicaceae have been discussed...
December 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29286836/are-contact-lens-discomfort-or-soft-contact-lens-material-properties-associated-with-alterations-in-the-corneal-sub-basal-nerve-plexus
#15
Alberto López-De La Rosa, Cristina Arroyo-Del Arroyo, Pilar Cañadas, Alberto López-Miguel, Margarita Calonge, Amalia Enríquez-De-Salamanca, María J González-García
PURPOSE: To study whether contact lens (CL) discomfort and some properties of soft CL materials are associated with alterations in the nerve fibers morphology and density of dendritic cells of the corneal sub-basal nerve plexus. MATERIALS AND METHODS: Forty soft CL wearers and 20 non-CL wearers were included. The Contact Lens Dry Eye Questionnaire-short form was administered to divide CL wearers based on their symptoms (20 symptomatic and 20 asymptomatic CL wearers were included)...
December 29, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29284749/visualizing-long-term-single-molecule-dynamics-in-vivo-by-stochastic-protein-labeling
#16
Hui Liu, Peng Dong, Maria S Ioannou, Li Li, Jamien Shea, H Amalia Pasolli, Jonathan B Grimm, Patricia K Rivlin, Luke D Lavis, Minoru Koyama, Zhe Liu
Our ability to unambiguously image and track individual molecules in live cells is limited by packing of multiple copies of labeled molecules within the resolution limit. Here we devise a universal genetic strategy to precisely control copy number of fluorescently labeled molecules in a cell. This system has a dynamic range of ∼10,000-fold, enabling sparse labeling of proteins expressed at different abundance levels. Combined with photostable labels, this system extends the duration of automated single-molecule tracking by two orders of magnitude...
December 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29281620/dual-strain-genital-herpes-simplex-virus-type-2-hsv-2-infection-in-the-us-peru-and-8-countries-in-sub-saharan-africa-a-nested-cross-sectional-viral-genotyping-study
#17
Christine Johnston, Amalia Magaret, Pavitra Roychoudhury, Alexander L Greninger, Daniel Reeves, Joshua Schiffer, Keith R Jerome, Cassandra Sather, Kurt Diem, Jairam R Lingappa, Connie Celum, David M Koelle, Anna Wald
BACKGROUND: Quantitative estimation of the extent to which the immune system's protective effect against one herpes simplex virus type 2 (HSV-2) infection protects against infection with additional HSV-2 strains is important for understanding the potential for HSV-2 vaccine development. Using viral genotyping, we estimated the prevalence of HSV-2 dual-strain infection and identified risk factors. METHODS AND FINDINGS: People with and without HIV infection participating in HSV-2 natural history studies (University of Washington Virology Research Clinic) and HIV prevention trials (HIV Prevention Trials Network 039 and Partners in Prevention HSV/HIV Transmission Study) in the US, Africa, and Peru with 2 genital specimens each containing ≥105 copies herpes simplex virus DNA/ml collected a median of 5 months apart (IQR: 2-11 months) were included...
December 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29279085/tick-borne-infections-in-dogs-and-horses-in-the-state-of-esp%C3%A3-rito-santo-southeast-brazil
#18
Fernanda de Toledo Vieira, Igor Cunha Lima Acosta, Thiago Fernandes Martins, Jonas Moraes Filho, Felipe da Silva Krawczak, Amália Regina Mar Barbieri, Leandro Egert, Danieli Rankel Fernandes, Fabio Ribeiro Braga, Marcelo Bahia Labruna, Reynaldo Dietze
This work aims to identify and quantify the percentage of Rickettsia spp., Ehrlichia spp., Babesia spp. and Hepatozoon spp. positive pet dogs, and to identify ticks collected on these animals in the state of Espírito Santo, in the Southeast region of Brazil. The study included 378 dogs, 226 females and 152 males, of various breeds and ages (mean age of 4.1 years). All animals were examined for ticks, and whole blood was collected and processed by conventional PCR protocols for Babesia spp., Anaplasmataceae, Hepatozoon spp...
January 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29275302/evaluation-of-vascular-proliferation-in-molecular-subtypes-of-breast-cancer
#19
Ionela Sevilla Bujor, Andreea Cioca, Raluca Amalia Ceaușu, Fulga Veaceslav, Cristian Nica, Anca Maria Cîmpean, Marius Raica
BACKGROUND: Angiogenesis plays a pivotal role in tumor development. Although microvessel density (MVD) is the most common method used for evaluation of angiogenesis, it has several limitations. Our aim was to evaluate MVD and microvessel proliferation (MVP) in a series of invasive breast carcinomas and analyze whether angiogenesis is influenced by the molecular phenotype of each tumor. MATERIALS AND METHODS: We examined vascular proliferation using double immunohistochemistry (CD34/Ki67) in a series of 54 invasive breast carcinomas and compared the results with standard MVD, molecular subtypes and other classical parameters...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29261806/main-and-epistatic-qtl-analyses-for-sclerotinia-head-rot-resistance-in-sunflower
#20
Jeremías Enrique Zubrzycki, Carla Andrea Maringolo, Carla Valeria Filippi, Facundo José Quiróz, Verónica Nishinakamasu, Andrea Fabiana Puebla, Julio A Di Rienzo, Alberto Escande, Verónica Viviana Lia, Ruth Amalia Heinz, Horacio Esteban Hopp, Gerardo D L Cervigni, Norma Beatriz Paniego
Sclerotinia Head Rot (SHR), a disease caused by Sclerotinia sclerotiorum, is one of the most limiting factors in sunflower production. In this study, we identified genomic loci associated with resistance to SHR to support the development of assisted breeding strategies. We genotyped 114 Recombinant Inbred Lines (RILs) along with their parental lines (PAC2 -partially resistant-and RHA266 -susceptible-) by using a 384 single nucleotide polymorphism (SNP) Illumina Oligo Pool Assay to saturate a sunflower genetic map...
2017: PloS One
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