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https://www.readbyqxmd.com/read/28212293/targeting-angiogenesis-in-biliary-tract-cancers-an-open-option
#1
REVIEW
Valeria Simone, Oronzo Brunetti, Luigi Lupo, Mario Testini, Eugenio Maiorano, Michele Simone, Vito Longo, Christian Rolfo, Marc Peeters, Aldo Scarpa, Amalia Azzariti, Antonio Russo, Domenico Ribatti, Nicola Silvestris
Biliary tract cancers (BTCs) are characterized by a bad prognosis and the armamentarium of drugs for their treatment is very poor. Although the inflammatory status of biliary tract represents the first step in the cancerogenesis, the microenvironment also plays a key role in the pathogenesis of BTCs, promoting tumor angiogenesis, invasion and metastasis. Several molecules, such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), are involved in the angiogenesis process and their expression on tumor samples has been explored as prognostic marker in both cholangiocarcinoma and gallbladder cancer...
February 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28211527/depth-specific-fluctuations-of-gene-expression-and-protein-abundance-modulate-the-photophysiology-in-the-seagrass-posidonia-oceanica
#2
Gabriele Procaccini, Miriam Ruocco, Lázaro Marín-Guirao, Emanuela Dattolo, Christophe Brunet, Daniela D'Esposito, Chiara Lauritano, Silvia Mazzuca, Ilia Anna Serra, Letizia Bernardo, Amalia Piro, Sven Beer, Mats Björk, Martin Gullström, Pimchanok Buapet, Lina M Rasmusson, Paulo Felisberto, Sylvie Gobert, John W Runcie, João Silva, Irene Olivé, Monya M Costa, Isabel Barrote, Rui Santos
Here we present the results of a multiple organizational level analysis conceived to identify acclimative/adaptive strategies exhibited by the seagrass Posidonia oceanica to the daily fluctuations in the light environment, at contrasting depths. We assessed changes in photophysiological parameters, leaf respiration, pigments, and protein and mRNA expression levels. The results show that the diel oscillations of P. oceanica photophysiological and respiratory responses were related to transcripts and proteins expression of the genes involved in those processes and that there was a response asynchrony between shallow and deep plants probably caused by the strong differences in the light environment...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210286/bilastine-in-allergic-rhinoconjunctivitis-and-urticaria-a-practical-approach-to-treatment-decisions-based-on-queries-received-by-the-medical-information-department
#3
REVIEW
Amalia Leceta, Ander Sologuren, Román Valiente, Cristina Campo, Luis Labeaga
BACKGROUND: Bilastine is a safe and effective commonly prescribed non-sedating H1-antihistamine approved for symptomatic treatment in patients with allergic disorders such as rhinoconjunctivitis and urticaria. It was evaluated in many patients throughout the clinical development required for its approval, but clinical trials generally exclude many patients who will benefit in everyday clinical practice (especially those with coexisting diseases and/or being treated with concomitant drugs)...
2017: Drugs in Context
https://www.readbyqxmd.com/read/28208141/the-phonetics-and-phonology-of-the-polish-calling-melodies
#4
Amalia Arvaniti, Marzena Żygis, Marek Jaskuła
Two calling melodies of Polish were investigated, the routine call, used to call someone for an everyday reason, and the urgent call, which conveys disapproval of the addressee's actions. A Discourse Completion Task was used to elicit the two melodies from Polish speakers using twelve names from one to four syllables long; there were three names per syllable count, and speakers produced three tokens of each name with each melody. The results, based on eleven speakers, show that the routine calling melody consists of a low F0 stretch followed by a rise-fall-rise; the urgent calling melody, on the other hand, is a simple rise-fall...
February 23, 2017: Phonetica
https://www.readbyqxmd.com/read/28205223/abdominal-adiposity-is-not-a-mediator-of-the-protective-effect-of-mediterranean-diet-on-colorectal-cancer
#5
Francesca Fasanelli, Daniela Zugna, Maria Teresa Giraudo, Vittorio Krogh, Sara Grioni, Salvatore Panico, Amalia Mattiello, Giovanna Masala, Saverio Caini, Rosario Tumino, Graziella Frasca, Veronica Sciannameo, Fulvio Ricceri, Carlotta Sacerdote
Adherence to the Mediterranean diet (MD) has a preventive effect on colorectal cancer (CRC). Several biological mechanisms have been hypothesized to explain this effect, but the involvement of clinical mediators has not been experimentally proven. We examined the role of abdominal adiposity (i.e. waist-to-hip ratio, WHR) as a potential mediator of the relationship between the MD and CRC in the Italian centres of the European Prospective Investigation into Cancer and Nutrition. We evaluated the effect of the Italian Mediterranean Index (IMI) on WHR and of WHR on CRC risk...
February 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28205047/pre-diagnosis-insulin-like-growth-factor-i-and-risk-of-epithelial-invasive-ovarian-cancer-by-histological-subtypes-a-collaborative-re-analysis-from-the-ovarian-cancer-cohort-consortium
#6
Jennifer Ose, Helena Schock, Elizabeth M Poole, Matti Lehtinen, Kala Visvanathan, Kathy Helzlsouer, Julie E Buring, I-Min Lee, Anne Tjønneland, Marie-Christine Boutron-Ruault, Antonia Trichopoulou, Amalia Mattiello, N Charlotte Onland-Moret, Elisabete Weiderpass, María-José Sánchez, Annika Idahl, Ruth C Travis, Sabina Rinaldi, Melissa A Merritt, Nicolas Wentzensen, Shelley S Tworoger, Rudolf Kaaks, Renée T Fortner
PURPOSE: Biologic evidence suggests that the Insulin-like growth factor (IGF)-family may be involved in the etiology of epithelial invasive ovarian cancer (EOC). However, prospective studies investigating the role of IGF-I in ovarian carcinogenesis have yielded conflicting results. METHODS: We pooled and harmonized data from 6 case-control studies nested within the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis IGF-I concentrations and subsequent risk of EOC...
February 16, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28198789/sustained-responses-to-measles-revaccination-at-24-months-in-hiv-infected-children-on-antiretroviral-therapy-in-kenya
#7
Laura P Newman, Anne Njoroge, Amalia Magaret, Bhavna H Chohan, Veronicah W Gitomea, Anna Wald, Jonathan Gorstein, Julie Overbaugh, Dalton Wamalwa, Elizabeth Maleche-Obimbo, Ruth Nduati, Carey Farquhar
BACKGROUND: There are limited data on whether HIV-infected children in resource-limited countries who are receiving antiretroviral therapy (ART) are able to produce sustained, protective levels of measles antibody after multiple measles vaccinations. METHODS: We administered an additional measles vaccine to HIV-infected children 15 months to 12 years of age receiving ART in Nairobi, Kenya. Measles antibody concentrations were determined by enzyme-linked immunosorbent assay (ELISA) at enrollment, one month, 12 months, and 24 months post revaccination...
February 13, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28195710/palladium-catalyzed-hydrohalogenation-of-1-6-enynes-hydrogen-halide-salts-and-alkyl-halides-as-convenient-hx-surrogates
#8
David A Petrone, Ivan Franzoni, Juntao Ye, Jose F Rodriguez, Amalia I Poblador-Bahamonde, Mark Lautens
Difficulties associated with the handling H2 and CO in metal-catalyzed processes has led to the development of chemical surrogates to these species. Despite many successful examples using this strategy, the application of convenient hydrogen halide (HX) surrogates in catalysis has lagged behind considerably. We now report the use of ammonium halides as HX surrogates to accomplish a novel Pd-catalyzed hydrohalogenation of enynes. These safe and practical salts avoid many drawbacks associated with traditional HX sources including toxicity and corrosiveness...
February 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28193203/first-insight-into-the-somatic-mutation-burden-of-neurofibromatosis-type-2-associated-grade-i-and-grade-ii-meningiomas-a-case-report-comprehensive-genomic-study-of-two-cranial-meningiomas-with-vastly-different-clinical-presentation
#9
Ramita Dewan, Alexander Pemov, Amalia S Dutra, Evgenia D Pak, Nancy A Edwards, Abhik Ray-Chaudhury, Nancy F Hansen, Settara C Chandrasekharappa, James C Mullikin, Ashok R Asthagiri, John D Heiss, Douglas R Stewart, Anand V Germanwala
BACKGROUND: Neurofibromatosis type 2 (NF2) is a rare autosomal dominant nervous system tumor predisposition disorder caused by constitutive inactivation of one of the two copies of NF2. Meningiomas affect about one half of NF2 patients, and are associated with a higher disease burden. Currently, the somatic mutation landscape in NF2-associated meningiomas remains largely unexamined. CASE PRESENTATION: Here, we present an in-depth genomic study of benign and atypical meningiomas, both from a single NF2 patient...
February 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28187454/grape-seed-extracts-modify-the-outcome-of-oxaliplatin-in-colon-cancer-cells-by-interfering-with-cellular-mechanisms-of-drug-cytotoxicity
#10
Letizia Porcelli, Rosa Maria Iacobazzi, Anna Elisa Quatrale, Carlo Bergamini, Nunzio Denora, Pasquale Crupi, Donato Antonacci, Anita Mangia, Giovanni Simone, Nicola Silvestris, Amalia Azzariti
Grape seed extracts are commonly utilized as dietary supplements for their antioxidant properties, even from cancer patients. However, whether these natural extracts interfere with chemotherapeutics utilized in colon cancer treatment is still poorly investigated. The cytotoxicity of extracts from Italia and Palieri cultivars either alone or in combination with oxaliplatin was evaluated in colon cancer cells. Grape seed extracts displayed anti-proliferative activity depending on the concentration utilized through apoptosis induction...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28185346/bilateral-malt-lymphoma-of-the-breast
#11
Amalia González López, Javier Del Riego, Amaya Martín, Ato Rodríguez, Franciso Javier, Sonia Piernas, Melcior Sentís
No abstract text is available yet for this article.
February 10, 2017: Breast Journal
https://www.readbyqxmd.com/read/28176395/imaging-diagnosis-computed-tomography-findings-in-a-dog-with-spontaneous-transmural-migration-of-a-textiloma-into-the-cecum
#12
Agustina Anson, Juana D Carrillo, Alejandro Bayon, Maria Teresa Escobar, Juan Seva, Amalia Agut
A 3-year-old spayed female dog was presented with 3-month history of severe bilateral uveitis subsequent to previous ovariohysterectomy. Physical examination revealed moderate abdominal pain. Computed tomography showed a nonobstructive heterogeneous mass-like lesion with a speckled gas pattern (spongiform pattern) within the cecum. Exploratory laparotomy revealed a surgical swab in the lumen of the cecum with severe adhesions. Histopathological examination demonstrated a chronic inflammatory pyogranulomatous reaction to the retained swab embedded within the intestinal wall, consistent with transmural migration of the swab from the peritoneal cavity into the cecum...
February 7, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28173834/osteoprotegerin-and-breast-cancer-risk-by-hormone-receptor-subtype-a-nested-case-control-study-in-the-epic-cohort
#13
Renée T Fortner, Danja Sarink, Helena Schock, Theron Johnson, Anne Tjønneland, Anja Olsen, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Domenico Palli, Sabina Sieri, Amalia Mattiello, Rosario Tumino, Fulvio Ricceri, H Bas Bueno-de-Mesquita, Petra H M Peeters, Carla H Van Gils, Elisabete Weiderpass, Eiliv Lund, J Ramón Quirós, Antonio Agudo, Maria-José Sánchez, María-Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Tim Key, Kay-Tee Khaw, Sabina Rinaldi, Laure Dossus, Marc Gunter, Melissa A Merritt, Elio Riboli, Rudolf Kaaks
BACKGROUND: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study. METHODS: A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort...
February 8, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28167333/regional-asymmetry-of-metabolic-and-antioxidant-profile-in-the-sciaenid-fish-shi-drum-umbrina-cirrosa-white-muscle-response-to-starvation-and-refeeding
#14
M Carmen Hidalgo, Amalia E Morales, Marta Arizcun, Emilia Abellán, Gabriel Cardenete
The objective of the present study is to characterize the metabolic and antioxidant profile of white muscle of shi drum in two sites of the body, anterior dorsal (AM) and posterior dorsal (PM) portions. In addition, it will be analyzed the possible effect of starvation and a subsequent refeeding, with two different protocols, pair feeding and ad libitum. Activities of key enzymes of intermediary metabolism and of antioxidant enzymes, as well as lipid peroxidation, as an index of oxidative stress, were evaluated...
February 1, 2017: Redox Biology
https://www.readbyqxmd.com/read/28163169/does-maoa-increase-susceptibility-to-prenatal-stress-in-young-children
#15
Suena H Massey, Amalia E Hatcher, Caron A C Clark, James L Burns, Daniel S Pine, Andrew D Skol, Daniel K Mroczek, Kimberly A Espy, David Goldman, Edwin Cook, Lauren S Wakschlag
BACKGROUND: We previously demonstrated a gene-by-prenatal-environment interaction whereby the monoamine oxidase A gene (MAOA) modified the impact of prenatal tobacco exposure (PTE) on adolescent disruptive behavior (DB), with the MAOA risk genotype varying by sex. We extend this work by examining whether this mechanism is evident with another common adversity, prenatal stress exposure (PSE), and whether sex differences are present earlier in development in closer proximity to exposure...
February 3, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28158203/silymarin-suppresses-basal-and-stimulus-induced-activation-exhaustion-differentiation-and-inflammatory-markers-in-primary-human-immune-cells
#16
Erica S Lovelace, Nicholas J Maurice, Hannah W Miller, Chloe K Slichter, Robert Harrington, Amalia Magaret, Martin Prlic, Stephen De Rosa, Stephen J Polyak
Silymarin (SM), and its flavonolignan components, alter cellular metabolism and inhibit inflammatory status in human liver and T cell lines. In this study, we hypothesized that SM suppresses both acute and chronic immune activation (CIA), including in the context of HIV infection. SM treatment suppressed the expression of T cell activation and exhaustion markers on CD4+ and CD8+ T cells from chronically-infected, HIV-positive subjects. SM also showed a trend towards modifying CD4+ T cell memory subsets from HIV+ subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28153513/first-estimates-of-the-global-and-regional-incidence-of-neonatal-herpes-infection
#17
Katharine J Looker, Amalia S Magaret, Margaret T May, Katherine M E Turner, Peter Vickerman, Lori M Newman, Sami L Gottlieb
BACKGROUND: Neonatal herpes is a rare but potentially devastating condition with an estimated 60% fatality rate without treatment. Transmission usually occurs during delivery from mothers with herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) genital infection. However, the global burden has never been quantified to our knowledge. We developed a novel methodology for burden estimation and present first WHO global and regional estimates of the annual number of neonatal herpes cases during 2010-15...
January 30, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28139151/age-related-macular-degeneration-and-mortality-a-systematic-review-and-meta-analysis
#18
Myra B McGuinness, Amalia Karahalios, Robert P Finger, Robyn H Guymer, Julie A Simpson
PURPOSE: Age-related macular degeneration (AMD) is the leading cause of severe, irreversible vision loss in older adults. Evidence for an association between AMD and mortality remains inconclusive despite evidence for an association with cardiovascular and inflammatory diseases. We aim to compare all-cause, cardiovascular and cancer mortality between those with early or late AMD and control study participants. METHODS: A protocol was registered at PROSPERO (CRD42015020622)...
January 31, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28139069/evolution-of-imidacloprid-resistance-in-myzus-persicae-in-greece-and-susceptibility-data-for-spirotetramat
#19
Costas Ch Voudouris, Martin S Williamson, Panagiotis J Skouras, Amalia N Kati, Anastasia J Sahinoglou, John T Margaritopoulos
BACKGROUND: Myzus persicae s.l. is a major crop pest globally and has evolved resistance to a range of insecticide classes making it increasingly difficult to control in some areas. Here we compare bioassay monitoring data for two important compounds, imidacloprid and spirotetramat, on field samples/clones collected in Greece. RESULTS: A total of 122 aphid samples/clones from central and northern Greece were examined in dose-response bioassays with imidacloprid...
January 31, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28134760/influence-of-transgenic-metallothionein-1-on-gliosis-ca1-neuronal-loss-and-brain-metal-levels-of-the-tg2576-mouse-model-of-alzheimer-s-disease
#20
Gemma Comes, Yasmina Manso, Anna Escrig, Olaya Fernandez-Gayol, Paula Sanchis, Amalia Molinero, Mercedes Giralt, Javier Carrasco, Juan Hidalgo
The mouse model of Alzheimer's disease (AD), Tg2576 mice (APP), has provided valuable information, such as the role of the metallothionein (MT) family in their behavioral and amyloidosis phenotypes. In this study, we further characterize the role of MT-1 by crossing Mt1-overexpressing mice with Tg2576 mice (APPTgMT). In 14-month-old mice, MT-1(/2) protein levels were dramatically increased by Mt1 overexpression throughout the cortex (Cx), which showed a prominent caudal-rostral gradient, and the hippocampus (HC)...
January 26, 2017: International Journal of Molecular Sciences
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