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https://www.readbyqxmd.com/read/28643029/impact-of-preventable-risk-factors-on-stroke-in-the-epicor-study-does-gender-matter
#1
Slavica Trajkova, Angelo d'Errico, Fulvio Ricceri, Francesca Fasanelli, Valeria Pala, Claudia Agnoli, Rosario Tumino, Graziella Frasca, Giovanna Masala, Calogero Saieva, Paolo Chiodini, Amalia Mattiello, Carlotta Sacerdote, Salvatore Panico
OBJECTIVES: The effect of modifiable stroke risk factors in terms of prevented cases remains unclear due to sex-specific disease rate and risk factors prevalence. Our aim was to estimate their impact on stroke by gender through population-attributable fraction (PAF), preventive fraction (PF) and their combination in EPIC-Italian cohort. METHODS: 43,976 participants, age 34-75, and free of cardiovascular disease at baseline (1993-1998) were followed up for almost 11 years...
June 22, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28636690/opioid-use-in-trauma-combating-the-opidemic-through-thoughtful-prescribing-practices
#2
Crystal Webb, Amalia Cochran
No abstract text is available yet for this article.
June 21, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28626472/in-iga-nephropathy-glomerulosclerosis-is-associated-with-increased-urinary-cd80-excretion-and-urokinase-type-plasminogen-activator-receptor-positive-podocyturia
#3
Hernán Trimarchi, Romina Canzonieri, Amalia Schiel, Cristian Costales-Collaguazo, Aníbal Stern, Matías Paulero, Tatiana Rengel, José Andrews, Alejandro Iotti, Mariano Forrester, Fernando Lombi, Vanesa Pomeranz, Romina Iriarte, Alexis Muryan, Elsa Zotta
BACKGROUND: Podocyturia may determine the evolution to podocytopenia, glomerulosclerosis, and renal failure. According to the Oxford classification of IgA nephropathy (IgAN), the S1 lesion describes glomerulosclerosis. Urokinase-type plasminogen activator receptor (uPAR) participates in podocyte attachment, while CD80 increases in glomerulosclerosis. We measured uPAR-positive urinary podocytes and urinary CD80 (uCD80) in controls and in IgAN subjects with M1E0S0T0 and M1E0S1T0 Oxford scores to assess a potential association between podocyturia, inflammation, and glomerulosclerosis...
May 2017: Nephron Extra
https://www.readbyqxmd.com/read/28624661/targeting-human-liver-cancer-cells-with-lactobionic-acid-g-4-pamam-fitc-sorafenib-loaded-dendrimers
#4
Iacobazzi Rosa Maria, Porcelli Letizia, Lopedota Angela Assunta, Laquintana Valentino, Lopalco Antonio, Cutrignelli Annalisa, Altamura Emiliano, Di Fonte Roberta, Azzariti Amalia, Franco Massimo, Denora Nunzio
Reported here is the synthesis and biological evaluation of the asialoglycoprotein receptor (ASGP-R) targeted fourth generation poliamidoamine dendrimer (G(4)-PAMAM) loaded with sorafenib. The ASGP-R targeted dendrimer was obtained by conjugation of Lactobionic acid (La) to the G(4)-PAMAM dendrimer, followed by acetylation (Ac) of the free amino groups in order to reduce the non-specific interactions with the cell membrane. Moreover, by additionally grafting fluorescein (FITC), it was easy to characterize the internalization pathway and the intracellular fate of the targeted dendrimer Ac-La-G(4)-PAMAM-FITC...
June 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28621425/epigenetic-mechanism-of-fmr1-inactivation-in-fragile-x-syndrome
#5
Merav Hecht, Amalia Tabib, Tamar Kahan, Shari Orlanski, Michal Gropp, Yuval Tabach, Ofra Yanuka, Nissim Benvenisty, Ilana Keshet, Howard Cedar
Fragile X syndrome is the most frequent cause of inherited intellectual disability. The primary molecular defect in this disease is the expansion of a CGG repeat in the 5' region of the fragile X mental retardation1 (FMR1) gene, leading to de novo methylation of the promoter and inactivation of this otherwise normal gene, but little is known about how these epigenetic changes occur during development. In order to gain insight into the nature of this process, we have used cell fusion technology to recapitulate the events that occur during early embryogenesis...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/28618823/effects-of-rhythm-and-phrase-final-lengthening-on-word-spotting-in-korean
#6
Hae-Sung Jeon, Amalia Arvaniti
A word-spotting experiment was conducted to investigate whether rhythmic consistency and phrase-final lengthening facilitate performance in Korean. Listeners had to spot disyllabic and trisyllabic words in nonsense strings organized in phrases with either the same or variable syllable count; phrase-final lengthening was absent, or occurring either in all phrases or only in the phrase immediately preceding the target. The results show that, for disyllabic targets, inconsistent syllable count and lengthening before the target led to fewer errors...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28617632/evolutionary-determinants-of-morphological-polymorphism-in-colonial-animals
#7
Carl Simpson, Jeremy B C Jackson, Amalia Herrera-Cubilla
Colonial animals commonly exhibit morphologically polymorphic modular units that are phenotypically distinct and specialize in specific functional tasks. But how and why these polymorphic modules have evolved is poorly understood. Across colonial invertebrates, there is wide variation in the degree of polymorphism, from none in colonial ascidians to extreme polymorphism in siphonophores, such as the Portuguese man-of-war. Bryozoa are a phylum of exclusively colonial invertebrates that uniquely exhibit almost the entire range of polymorphism, from monomorphic species to others that rival siphonophores in their polymorphic complexity...
July 2017: American Naturalist
https://www.readbyqxmd.com/read/28617266/sustainable-public-health-systems-for-rare-diseases
#8
Rita Maria Ferrelli, Amalia Egle Gentile, Marta De Santis, Domenica Taruscio
INTRODUCTION: In the framework of the Joint Action for Rare Diseases (RD-ACTION), a specific task was defined to identify mechanisms influencing sustainability, equity and resilience of health systems for rare diseases (RDs). METHOD: Literature narrative review on health systems sustainability and resilience for RDs. Years: 2000-2015. Databases: PubMed, Scopus, EBSCOHost, EMBAL, PASCAL, EMBASE, STN International and GoogleScholar. ANALYSIS: interpretive synthesis concept and thematic analysis (Dixon-Wood, et al...
April 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28611805/transcriptomic-analysis-in-strawberry-fruits-reveals-active-auxin-biosynthesis-and-signaling-in-the-ripe-receptacle
#9
Elizabeth Estrada-Johnson, Fabiana Csukasi, Carmen M Pizarro, José G Vallarino, Yulia Kiryakova, Amalia Vioque, Javier Brumos, Nieves Medina-Escobar, Miguel A Botella, José M Alonso, Alisdair R Fernie, José F Sánchez-Sevilla, Sonia Osorio, Victoriano Valpuesta
The role of auxin in ripening strawberry (Fragaria ×ananassa) fruits has been restricted to the early stages of development where the growth of the receptacle is dependent on the delivery of auxin from the achenes. At later stages, during enlargement of the receptacle, other hormones have been demonstrated to participate to different degrees, from the general involvement of gibberellins and abscisic acid to the more specific of ethylene. Here we report the involvement of auxin at the late stages of receptacle ripening...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28610421/electro-acupuncture-therapy-increases-serum-interferon-%C3%AE-levels-in-rats-with-7-12-dimethylbenz-%C3%AE-anthracene-dmba-induced-breast-tumors
#10
Laily Yuliatun, Sholihatul Amalia, Aliyah Adek Rahma, Laily Aflahal Yaumi
Objective: To determine the effect of electro-acupuncture (EA) treatment on serum levels of interferon-γ (IFN-γ) in rats with 7,12-dimethylbenz(α)anthracene (DMBA)-induced breast tumors. Methods: Twenty five female Wistar rats were divided randomly into 5 groups: normal group (N; neither DMBA-induced nor treated with EA); control group (C; DMBA-induced only); EA 3 days : (DMBA-induced + EA for 3 days); EA 5 days: (DMBA-induced + EA for 5 days); EA 10 days: (DMBA-induced + EA for 10 days) group. Animals were acclimatized from day 1 to day 7...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28609908/scale-insects-hemiptera-coccomorpha-on-sugarcane-in-colombia-with-description-of-a-new-species-of-tillancoccus-ben-dov-coccidae
#11
Alejandro Caballero, Andrea Amalia Ramos-Portilla, Takumasa Kondo
Herein we describe a new species, Tillancoccus koreguajae Caballero & Ramos, sp. n. (Hemiptera: Coccidae) from Colombia collected on sugarcane. Pinnaspis strachani (Cooley) is also recorded on sugarcane for the first time worldwide. An updated list of seven species of Coccomorpha on sugarcane in Colombia is provided, including information on its distribution, biology, and mutualistic ants for each species. Seven species of scale insects (Hemiptera: Coccomorpha) have been recorded previously on sugarcane, Saccharum officinarum L...
May 2, 2017: Zootaxa
https://www.readbyqxmd.com/read/28603688/novel-piroplasmid-and-hepatozoon-organisms-infecting-the-wildlife-of-two-regions-of-the-brazilian-amazon
#12
Herbert S Soares, Arlei Marcili, Amália R M Barbieri, Antonio H H Minervino, Thiago Rocha Moreira, Solange M Gennari, Marcelo B Labruna
During 2009-2012, wild animals were sampled in two areas within the Amazon biome of Brazil, in the states of Mato Grosso and Pará. Animal tissues and blood were molecularly tested for the presence of Piroplasmida (genera Babesia, Theileria, Cytauxzoon) or Hepatozoon DNA. Overall, 181 wild animals comprising 36 different species (2 reptiles, 5 birds, and 29 mammals) were sampled. The following Piroplasmida agents were detected: Cytauxzoon felis in one ocelot (Leopardus pardalis), Theileria cervi in two red brocket deer (Mazama americana), Theileria spp...
August 2017: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/28596425/outcomes-of-hematopoietic-cell-transplantation-using-donors-or-recipients-with-inherited-chromosomally-integrated-hhv-6
#13
Joshua A Hill, Amalia S Magaret, Ruth Hall-Sedlak, Anna Mikhaylova, Meei-Li Huang, Brenda M Sandmaier, John A Hansen, Keith R Jerome, Danielle M Zerr, Michael Boeckh
Human herpesvirus 6 (HHV-6) species have a unique ability to integrate into chromosomal telomeres. Mendelian inheritance via gametocyte integration results in HHV-6 in every nucleated cell. The epidemiology and clinical impact of inherited chromosomally integrated (iciHHV-6) in hematopoietic cell transplant (HCT) recipients is unclear. We identified 4,319 HCT donor-recipient pairs (8,638 subjects) who received an allogeneic HCT and had archived pre-HCT peripheral blood mononuclear cell samples. We screened these samples for iciHHV-6 and compared characteristics of HCT recipients and donors with iciHHV-6 to recipients and donors without iciHHV-6, respectively...
June 8, 2017: Blood
https://www.readbyqxmd.com/read/28595952/trans-resveratrol-enriched-maternal-diet-protects-the-immature-hippocampus-from-perinatal-asphyxia-in-rats
#14
Sebastian Isac, Anca Maria Panaitescu, Ana Spataru, Mara Iesanu, Alexandra Totan, Amalia Udriste, Natalia Cucu, Gheorghe Peltecu, Leon Zagrean, Ana-Maria Zagrean
Trans-resveratrol (tRESV), a polyphenol with antioxidant properties, is common in many food sources, hence easily accessible for study as a maternal dietary supplement in perinatal asphyxia (PA). Hypoxic-ischemic encephalopathy secondary to PA affects especially vulnerable brain areas such as hippocampus and is a leading cause of neonatal morbidity. The purpose of this study is to identify new epigenetic mechanisms of brain inflammation and injury related to PA and to explore the benefit of tRESV enriched maternal diet...
June 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28592517/consumption-of-fish-is-not-associated-with-risk-of-differentiated-thyroid-carcinoma-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-study
#15
Raul Zamora-Ros, Jazmín Castañeda, Sabina Rinaldi, Valerie Cayssials, Nadia Slimani, Elisabete Weiderpass, Konstantinos K Tsilidis, Marie-Christine Boutron-Ruault, Kim Overvad, Anne K Eriksen, Anne Tjønneland, Tilman Kühn, Verena Katzke, Heiner Boeing, Antonia Trichopoulou, Carlo La Vecchia, Anastasia Kotanidou, Domenico Palli, Sara Grioni, Amalia Mattiello, Rosario Tumino, Veronica Sciannameo, Eiliv Lund, Susana Merino, Elena Salamanca-Fernández, Pilar Amiano, José María Huerta, Aurelio Barricarte, Ulrika Ericson, Martin Almquist, Joakim Hennings, Maria Sandström, H Bas Bueno-de-Mesquita, Petra H Peeters, Kay-Tee Khaw, Nicholas J Wareham, Julie A Schmidt, Amanda J Cross, Elio Riboli, Augustin Scalbert, Isabelle Romieu, Antonio Agudo, Silvia Franceschi
Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk.Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study.Methods: EPIC is a cohort of >500,000 men and women, mostly aged 35-70 y, who were recruited in 10 European countries...
June 7, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28591395/the-many-faces-of-demyelinating-diseases-acute-disseminated-encephalomyelitis-and-guillain-barr%C3%A3-syndrome-in-the-same-patient
#16
Régis Augusto Reis Trindade, Amália Izaura Nair Medeiros Klaes, Juliana Ávila Duarte
No abstract text is available yet for this article.
May 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28587076/structure-modification-of-an-active-azo-compound-as-a-route-to-new-antimicrobial-compounds
#17
Simona Concilio, Lucia Sessa, Anna Maria Petrone, Amalia Porta, Rosita Diana, Pio Iannelli, Stefano Piotto
Some novel (phenyl-diazenyl)phenols 3a-g were designed and synthesized to be evaluated for their antimicrobial activity. A previously synthesized molecule, active against bacteria and fungi, was used as lead for modifications and optimization of the structure, by introduction/removal or displacement of hydroxyl groups on the azobenzene rings. The aim of this work was to evaluate the consequent changes of the antimicrobial activity and to validate the hypothesis that, for these compounds, a plausible mechanism could involve an interaction with protein receptors, rather than an interaction with membrane...
May 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28586309/italian-real-life-experience-with-brentuximab-vedotin-results-of-a-large-observational-study-on-234-relapsed-refractory-hodgkin-s-lymphoma
#18
Cinzia Pellegrini, Alessandro Broccoli, Alessandro Pulsoni, Luigi Rigacci, Caterina Patti, Guido Gini, Donato Mannina, Monica Tani, Chiara Rusconi, Alessandra Romano, Anna Vanazzi, Barbara Botto, Armando Santoro, Stefan Hoaus, Gian Matteo Rigolin, Pellegrino Musto, Patrizio Mazza, Stefano Molica, Paolo Corradini, Angelo Fama, Francesco Gaudio, Michele Merli, Fioravante Ronconi, Giuseppe Gritti, Daniele Vallisa, Patrizia Tosi, Anna Marina Liberati, Antonello Pinto, Vincenzo Pavone, Filippo Gherlinzoni, Maria Paola Bianchi, Stefano Volpetti, Livio Trentin, Maria Cecilia Goldaniga, Maurizio Bonfichi, Amalia De Renzo, Corrado Schiavotto, Michele Spina, Angelo Michele Carella, Vittorio Stefoni, Lisa Argnani, Pier Luigi Zinzani
A large Italian multicenter observational retrospective study was conducted on the use of brentuximab vedotin (BV) for patients with relapsed Hodgkin's lymphoma (HL) to check if clinical trial results are confirmed even in a real life context. 234 CD30+ HL patients were enrolled. Best response was observed after a median of 4 cycles in 140 patients (59.8%): 74 (31.6%) patients obtained a complete response (CR) and 66 (28.2%) achieved a partial response (PR); overall response rate at the end of the treatment was 48...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28584855/febrile-rhinovirus-illness-during-pregnancy-is-associated-with-low-birth-weight-in-nepal
#19
Erin K Philpott, Janet A Englund, Joanne Katz, James Tielsch, Subarna Khatry, Stephen C LeClerq, Laxman Shrestha, Jane Kuypers, Amalia S Magaret, Mark C Steinhoff, Helen Y Chu
BACKGROUND: Adverse birth outcomes, including low birth weight (LBW), defined as <2500 grams, small-for-gestational-age (SGA), and prematurity, contribute to 60%-80% of infant mortality worldwide and may be related to infections during pregnancy. The aim of this study was to assess whether febrile human rhinovirus (HRV) illness is associated with adverse birth outcomes. METHODS: Active household-based weekly surveillance was performed for respiratory illness episodes in pregnant women as part of a community-based, prospective, randomized trial of maternal influenza immunization in rural Nepal...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28577539/inguinal-and-anorectal-lymphogranuloma-venereum-a-case-series-from-a-sexually-transmitted-disease-center-in-rome-italy
#20
Alessandra Latini, Mauro Zaccarelli, Maria Grazia Paglia, Maria Gabriella Donà, Amalia Giglio, Domenico Moretto, Antonella Vulcano, Massimo Giuliani, Manuela Colafigli, Marina Ambrifi, Fulvia Pimpinelli, Antonio Cristaudo
BACKGROUND: Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by L1, L2, L3 serovars of C. trachomatis (CT). Since 2003, LGV cases have been increasing in Europe. Aim of this report is to describe the LGV cases diagnosed in the largest STI center in Rome, Italy, from 2000 to 2016. This report shows that two clinically and epidemiologically different series of cases exist, and that, at present, the ano-rectal LGV represents the clinical variant occurring more frequently among men having sex with men (MSM), particularly those HIV-infected...
June 2, 2017: BMC Infectious Diseases
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