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Elizabeth Rodrigues Alfenas, Amália Moreno, Paul Benjamin Tanner, Henrique Duque Netto, Maria Fernanda Lopes Fonseca, Fernando Gonçalves Rios
The clinical report describes a case of a 14-year-old patient with a traumatic amputation of the left auricle and severe hypertrophic scarring. The management of peri-implant soft tissue was challenging, but successful in the rehabilitation of a patient with auricular prosthesis retained by implants. The prosthesis restored the patient's facial aesthetics and contributed not only to function, but also to psychosocial well-being.
September 19, 2017: Journal of Craniofacial Surgery
María José García-Meseguer, Amalia Delicado-Soria, Ramón Serrano-Urrea
Benefits of dietary fiber go beyond its effect on chronic diseases associated with development. Consequently, the pattern of fiber intake has been considered an indicator for diet quality. Young adults are especially vulnerable to a food environment that drives an increase in chronic diseases linked to economic development. The aim of this work was to characterize patterns of fiber intake among university students. A cross-sectional study was conducted on a sample of 730 students enrolled at the University of Castilla-La Mancha (Spain), the University of Carthage (Tunisia), and Florida International University (USA)...
September 18, 2017: Nutrients
Janika Nättinen, Antti Jylhä, Ulla Aapola, Amalia Enríquez-de-Salamanca, José Pinto-Fraga, Alberto López-Miguel, María J González-García, Michael E Stern, Margarita Calonge, Lei Zhou, Matti Nykter, Hannu Uusitalo, Roger Beuerman
PURPOSE: It was hypothesized that tear protein biomarkers could predict the effects of topical steroid treatment and desiccating stress in patients with dry eye disease (DED). To test this concept, a randomized, double-masked, controlled clinical trial with 41 patients was conducted. METHODS: The patients were treated topically with either 0.1% fluorometholone (FML) or polyvinyl alcohol (PA). Tear samples were collected using 1 μl glass capillaries at recruitment into the study and after a 3-week treatment period, both before and after 2 h exposure to desiccating stress, in a controlled environment chamber...
September 13, 2017: Ocular Surface
Luigi Rossiello, Amalia Lupoli, Francescamaria Ruggiero, Amedeo Boscaino, Roberto Cozzi
No abstract text is available yet for this article.
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Helen Y Chu, James Tielsch, Joanne Katz, Amalia S Magaret, Subarna Khatry, Stephen C LeClerq, Laxman Shrestha, Jane Kuypers, Mark C Steinhoff, Janet A Englund
BACKGROUND: Respiratory syncytial virus (RSV) is the most important viral cause of pneumonia in children. RSV-specific antibody (ab) protects infants from disease, and may be increased by a potential strategy of maternal RSV vaccination. OBJECTIVES: To describe the effect of RSV antibody on RSV infection risk in infants in a resource-limited setting. STUDY DESIGN: In a prospective study in Nepal, women were enrolled during pregnancy and maternal and infant cord blood were collected at birth...
September 2, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Denis Mihaela Panaitescu, Irina Lupescu, Adriana Nicoleta Frone, Ioana Chiulan, Cristian Andi Nicolae, Vlad Tofan, Amalia Stefaniu, Raluca Somoghi, Roxana Trusca
Medium chain-length PHAs (mPHAs) are flexible elastomeric biopolymers with valuable properties for biomedical applications like artificial arteries and other medical implants. However, an environmentally friendly and high productivity process together with the tuning of the mechanical and biological properties of mPHAs are mandatory for this purpose. Here, for the first time, a melt processing technique was applied for the preparation of bionanocomposites starting from poly(3-hydroxyoctanoate) (PHO) and bacterial cellulose nanofibers (BC)...
September 11, 2017: Biomacromolecules
Miguel Ángel Martínez-García, Erica Riveiro-Falkenbach, José L Rodríguez-Peralto, Eduardo Nagore, Antonio Martorell-Calatayud, Francisco Campos-Rodríguez, Ramón Farré, Luis Hernández Blasco, Jose Bañuls Roca, Eusebi Chiner Vives, Alicia Sánchez-de-la-Torre, Jorge Abad Capa, Josep Maria Montserrat, Isaac Almendros, Amalia Pérez-Gil, Valentin Cabriada Nuño, Irene Cano-Pumarega, Jaime Corral Peñafiel, Trinidad Diaz Cambriles, Olga Mediano, Joan Dalmau Arias, David Gozal
Melanoma is a highly prevalent cancer that is associated with substantial mortality. Although clinical staging procedures can serve as relatively robust prognostic indicators, we aimed to determine whether assessments of the abundance of hypoxia inducible factor-1α (HIF-1α) or vascular endothelial growth factor (VEGF) in postexcisional melanoma tumor tissues may enable more accurate determination of tumor aggressiveness. We carried out a multicenter prospective study, in which we systematically evaluated 376 consecutive patients diagnosed with melanoma, and performed histochemical assessments for both HIF-1α and VEGF immunoreactivity in the tumor biopsies...
September 6, 2017: Melanoma Research
Letizia Porcelli, Rosa Maria Iacobazzi, Anna Elisa Quatrale, Carlo Bergamini, Nunzio Denora, Pasquale Crupi, Donato Antonacci, Anita Mangia, Giovanni Simone, Nicola Silvestris, Amalia Azzariti
Grape seed extracts are commonly utilized as dietary supplements for their antioxidant properties, even from cancer patients. However, whether these natural extracts interfere with chemotherapeutics utilized in colon cancer treatment is still poorly investigated. The cytotoxicity of extracts from Italia and Palieri cultivars either alone or in combination with oxaliplatin was evaluated in colon cancer cells. Grape seed extracts displayed anti-proliferative activity depending on the concentration utilized through apoptosis induction...
August 1, 2017: Oncotarget
Elfriede Agyemang, Quynh-An Le, Terri Warren, Amalia S Magaret, Stacy Selke, Christine Johnston, Keith R Jerome, Anna Wald
BACKGROUND: US Food and Drug Administration-approved enzyme-linked immunoassays (EIA) for determining type-specific herpes simplex virus (HSV) serostatus are widely used in clinical practice. We compared the performance of such assays with the University of Washington Western blot (UW WB) in patients who sought confirmation of their HSV serology result. METHODS: We reviewed charts of all persons evaluated at the Westover Heights Clinic in Portland, Oregon, from July 2010 through September 2015, who had a HSV EIA, followed by UW WB...
August 22, 2017: Sexually Transmitted Diseases
Liliana N Ceci, Susana B Mattar, Amalia A Carelli
This study provides information about the chemical quality (quality indices, fatty acid profile, total polyphenols (PPs), tocopherols and pigments) and oxidative stability index (OSI) of virgin olive oils of Arbequina, Changlot Real and Coratina cultivars (San Juan province, Argentina). The influence of the cultivar and the effect of earlier harvest dates on the yields (OY), quality and OSI of the oils were also evaluated. All the oils were classified as extra virgin. The OY (L/100kg) averaged: Arbequina=13...
October 2017: Food Research International
Andreea Cioca, Anca Maria Cimpean, Raluca Amalia Ceausu, Valeria Tarlui, Alina Toma, Irina Marin, Marius Raica
BACKGROUND: Podoplanin (PDPN), a mucin-type transmembrane glycoprotein, is expressed in a variety of human cancer types, and contributes to tumor progression. Our goal was to evaluate PDPN expression in hepatocellular carcinoma (HCC) using both immunohistochemistry (IHC) and RNAscope in situ hybridization. MATERIALS AND METHODS: Twenty patients with HCC who underwent partial hepatectomy with curative intent were retrospectively analyzed. RESULTS: IHC gave positive results in 11 cases, while RNAscope assay for PDPN detected amplification in 16 cases...
September 2017: Cancer Genomics & Proteomics
Amália M Bielemann, Raissa M Marcello-Machado, Fábio Renato Manzolli Leite, Frederico Canato Martinho, Otacílio Luiz Chagas-Júnior, Altair Antoninha Del Bel Cury, Fernanda Faot
No abstract text is available yet for this article.
September 4, 2017: Clinical Oral Investigations
Amalia Schiavetti, Giulia Varrasso, Paola Collini, Anna Clerico
The prognosis of relapsed Wilms tumor (WT) with diffuse anaplasia is dismal, therefore, novel therapeutic strategies need to be explored. We reported on 2 consecutive cases with relapsed anaplastic WT who presented a partial response after 2 courses of vincristine, irinotecan, and bevacizumab association. This regimen may have a role in the treatment of patients with anaplastic advanced WT.
August 30, 2017: Journal of Pediatric Hematology/oncology
Ciro Milite, Elisabetta Barresi, Eleonora Da Pozzo, Barbara Costa, Monica Viviano, Amalia Porta, Anna Messere, Gianluca Sbardella, Federico Da Settimo, Ettore Novellino, Sandro Cosconati, Sabrina Castellano, Sabrina Taliani, Claudia Martini
The quinazoline class was exploited to search for a new translocator protein (TSPO) fluorescent probe endowed with improved affinity and residence time (RT). Computational studies on an "in-house" collection of quinazoline derivatives, featuring highly steric demanding groups at the amide nitrogen, suggested that, despite their molecular extension, these ligands are still easily lodged in the TSPO binding site. Binding assays supported this hypothesis, highlighting a low nanomolar/subnanomolar affinity of these ligands, together with a higher RT of the representative compound 11 with respect to our previously reported indole-based fluorescent probe...
September 15, 2017: Journal of Medicinal Chemistry
Cesar A Rodriguez, Teresa Martin, Rebeca Lozano, Amalia Gomez, Juan J Cruz
Nasal septum perforation in patients with cancer receiving systemic therapy is rare, and its association with bevacizumab use has described recently in the literature. Here, we report the case of a 34-year-old woman with hormone-sensitive, HER-2/neu negative, metastatic breast cancer who develope a nasal septum perforation during the treatment with paclitaxel and bevacizumab.
August 27, 2017: Breast Journal
Fabio Minervini, Amalia Conte, Matteo Alessandro Del Nobile, Marco Gobbetti, Maria De Angelis
This study aimed at improving the functional attributes and shelf-life of burrata cheese by using protective lactobacilli (Lactobacillus plantarum LPAL and Lactobacillus rhamnosus LRB), fructoligosaccharides and inulin. Six burrata cheeses were made by using: i) the traditional protocol (control); ii) addition of 0.5% fructoligosaccharides and inulin (DF cheese); iii) protective lactobacilli in milk alone (PL cheese); iv) protective lactobacilli in milk and governing liquid (2PL cheese); v) protective lactobacilli in milk and dietary fibers (DF_PL cheese); and vi) protective lactobacilli in milk, governing liquid and dietary fibers (DF_2PL cheeses)...
August 25, 2017: Applied and Environmental Microbiology
Yinka Kerr, Melinda Mailhot, Alford A J Williams, Virginia Swezy, Linda Quick, Rudolf H Tangermann, Kirsten Ward, Amalia Benke, Anna Callaghan, Kathleen Clark, Brian Emery, Jessica Nix, Eleanor Aydlotte, Charlotte Newman, Benjamin Nkowane
In 1988, the by the World Health Assembly established the Global Polio Eradication Initiative, which consisted of a partnership among the World Health Organization (WHO), Rotary International, the Centers for Disease Control and Prevention (CDC), and the United Nations Children's Fund. By 2016, the annual incidence of polio had decreased by >99.9%, compared with 1988, and at the time of writing, only 3 countries in which wild poliovirus circulation has never been interrupted remain: Afghanistan, Nigeria, and Pakistan...
July 1, 2017: Journal of Infectious Diseases
Jessica E Yager, Amalia S Magaret, Steven R Kuntz, Stacy Selke, Meei-Li Huang, Lawrence Corey, Corey Casper, Anna Wald
Epstein-Barr virus (EBV) causes infectious mononucleosis and can lead to lymphoproliferative diseases. We evaluated the effects of valganciclovir on oral EBV shedding in a randomized, double-blind, placebo-controlled study. Twenty-six men received oral valganciclovir or daily placebo for 8 weeks, followed by a 2-week "washout period" and then 8 weeks of the alternative treatment. Valganciclovir reduced the proportion of days with EBV detected from 61.3% to 17.8% (relative risk, 0.28; 95% confidence interval [CI], ...
July 15, 2017: Journal of Infectious Diseases
Amalia Cochran, William B Elder, Leigh A Neumayer
OBJECTIVE: The authors sought to describe characteristics of effective mentoring relationships in academic surgery based upon lived experiences of mid-career and senior female academic surgeons. BACKGROUND: Prior qualitative work describes characteristics of successful mentoring relationships. However, no model exists of effective mentorship that is specific to academic surgery. METHODS: The authors conducted in-depth interviews with mid-career and senior female US academic surgeons about the impact of mentoring on professional development during 2014 and 2015...
August 23, 2017: Annals of Surgery
Marilena Larocca, Anna Maria Perna, Amalia Simonetti, Emilio Gambacorta, Alessandra Iannuzzi, Angela Perucatti, Rocco Rossano
Brassica phytochemicals exert a broad spectrum of health-promoting activities. The aim of this study was to investigate the possible beneficial effects of a cauliflower leaf powder (CLP)-enriched diet to prevent inflammation and oxidative stress resulting from injection of lipopolysaccharide (LPS) into rabbits. Animals (24 rabbits) were randomly divided into two groups and fed with a standard diet (SD) or a standard diet supplemented with a 100 g kg(-1) diet of CLP. After 60 days, six rabbits of both groups received a LPS injection (100 μg per kg body weight)...
September 20, 2017: Food & Function
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