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https://www.readbyqxmd.com/read/27912029/how-to-establish-a-bioregenerative-life-support-system-for-long-term-crewed-missions-to-the-moon-or-mars
#1
Yuming Fu, Leyuan Li, Beizhen Xie, Chen Dong, Mingjuan Wang, Boyang Jia, Lingzhi Shao, Yingying Dong, Shengda Deng, Hui Liu, Guanghui Liu, Bojie Liu, Dawei Hu, Hong Liu
To conduct crewed simulation experiments of bioregenerative life support systems on the ground is a critical step for human life support in deep-space exploration. An artificial closed ecosystem named Lunar Palace 1 was built through integrating efficient higher plant cultivation, animal protein production, urine nitrogen recycling, and bioconversion of solid waste. Subsequently, a 105-day, multicrew, closed integrative bioregenerative life support systems experiment in Lunar Palace 1 was carried out from February through May 2014...
December 2, 2016: Astrobiology
https://www.readbyqxmd.com/read/27910789/methoxyflavones-from-new-lingzhi-medicinal-mushroom-ganoderma-lingzhi-agaricomycetes
#2
Kuniyoshi Shimizu, Yhiya M Amen, Satoru Kaifuchi
Ganoderma lingzhi is one of the most famous medicinal fungi in the world. It has been used in folk medicine, especially in East Asian countries. It is also a white-rot fungus with strong wood degradation ability, especially against lignin. Different classes of bioactive natural products have been reported in Ganoderma, including triterpenes, polysaccharides, sterols, and peptides. The triterpenes and polysaccharides are the primary bioactive compounds of Ganoderma. We report for the first time the presence of 3 methoxyflavones as minor constituents in G...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910775/hepatoprotective-effects-and-mechanisms-of-action-of-triterpenoids-from-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes-on-%C3%AE-amanitin-induced-liver-injury-in-mice
#3
Huihui Wu, Shanshan Tang, Zhaoqin Huang, Qian Zhou, Ping Zhang, Zuohong Chen
Most fatal mushroom poisonings are caused by species of the genus Amanita; the amatoxins are responsible for acute liver failure and death in humans. Ganoderma lucidum is a well-known traditional medicinal mushroom that has been shown to have obvious hepatoprotective effects. This study evaluated the hepatoprotective effects of triterpenoids from G. lucidum on liver injury induced by a-amanitin (α-AMA) in mice and the mechanisms of action of these triterpenoids, including radical scavenging and antiapoptosis activities...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910768/pharmacological-properties-of-biocompounds-from-spores-of-the-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes-a-review
#4
Carlos Ricardo Soccol, Lucas Yamasaki Bissoqui, Cristine Rodrigues, Rosalia Rubel, Sandra R B R Sella, Fan Leifa, Luciana Porto de Souza Vandenberghe, Vanete Thomaz Soccol
Ganoderma lucidum is a well-known representative of mushrooms that have been used in traditional Chinese medicine for centuries. New discoveries related to this medicinal mushroom and its biological properties are frequently reported. However, only recently have scientists started to pay special attention to G. lucidum spores. This is in part because of the recent development of methods for breaking the spore wall and extracting biocompounds from the spore. Although some research groups are working with G. lucidum spores, data in the literature are still limited, and the methods used have not been systematized...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910761/investigation-of-requisites-for-the-optimal-mycelial-growth-of-the-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes-on-oil-palm-biomass-in-malaysia
#5
Surya Sudheer, Asgar Ali, Sivakumar Manickam
Rigorous research has been carried out regarding the cultivation of Ganoderma lucidum using different agricultural residues. Nevertheless, large-scale cultivation and the separation of active compounds of G. lucidum are still challenges for local farmers. The objective of this study was to evaluate the use of oil palm waste fibers such as empty fruit bunch fibers and mesocarp fibers as effective substrates for the growth of G. lucidum mycelia to study the possibility of solid-state cultivation and to determine the optimum conditions necessary for the growth of mycelia of this mushroom on these waste fibers...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27900385/aggregation-enhanced-emission-active-tetraphenylbenzene-cored-efficient-blue-light-emitter
#6
Lingzhi Li, Han Nie, Ming Chen, Jingzhi Sun, Anjun Qin, Ben Zhong Tang
A tetraphenylbenzene (TPB) cored luminophore of TPB-AC with aggregation-enhanced emission characteristics was designed and synthesized. TPB-AC could be potentially applied for the fabrication of high performance organic light-emitting diodes (OLEDs) with blue light emission.
November 30, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27898378/ag-n-doped-reduced-graphene-oxide-incorporated-with-molecularly-imprinted-polymer-an-advanced-electrochemical-sensing-platform-for-salbutamol-determination
#7
Junhua Li, Zhifeng Xu, Mengqin Liu, Peihong Deng, Siping Tang, Jianbo Jiang, Haibo Feng, Dong Qian, Lingzhi He
In this work, the metallic silver and non-metallic nitrogen co-doped reduced graphene oxide (Ag-N-RGO) was first synthesized by a simple and cost-effective strategy, and then a molecularly imprinted polymer (MIP) was formed in situ at the surface of the prepared composite via electropolymerization of o-phenylenediamine in the presence of salbutamol as the template molecule. The electrochemical characterizations demonstrate that the bifunctional graphene-based composite shows improved catalytic performance than that of pristine graphene doped with one-component or none...
November 10, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27894599/overexpression-of-the-homologous-lanosterol-synthase-gene-in-ganoderic-acid-biosynthesis-in-ganoderma-lingzhi
#8
De-Huai Zhang, Na Li, Xuya Yu, Peng Zhao, Tao Li, Jun-Wei Xu
Ganoderic acids (GAs) in Ganoderma lingzhi exhibit anticancer and antimetastatic activities. GA yields can be potentially improved by manipulating G. lingzhi through genetic engineering. In this study, a putative lanosterol synthase (LS) gene was cloned and overexpressed in G. lingzhi. Results showed that its overexpression (OE) increased the ganoderic acid (GA) content and the accumulation of lanosterol and ergosterol in a submerged G. lingzhi culture. The maximum contents of GA-O, GA-Mk, GA-T, GA-S, GA-Mf, and GA-Me in transgenic strains were 46...
November 25, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27882327/migration-of-btex-and-biodegradation-in-shallow-underground-water-through-fuel-leak-simulation
#9
Yaping Cheng, Yudao Chen, Yaping Jiang, Lingzhi Jiang, Liqun Sun, Liuyue Li, Junyu Huang
To provide more reasonable references for remedying underground water, fuel leak was simulated by establishing an experimental model of a porous-aquifer sand tank with the same size as that of the actual tank and by monitoring the underground water. In the tank, traditional gasoline and ethyl alcohol gasoline were poured. This study was conducted to achieve better understanding of the migration and distribution of benzene, toluene, ethyl benzene, and xylene (BTEX), which are major pollutants in the underground water...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27864280/edaravone-injection-reverses-learning-and-memory-deficits-in-a-rat-model-of-vascular-dementia
#10
Xu Li, Fen Lu, Wei Li, Lingzhi Qin, Yong Yao, Xuerong Ge, Qingkai Yu, Xinliang Liang, Dongmei Zhao, Xiaohong Li, Jiewen Zhang
Edaravone is a novel free radical scavenger that exerts neuroprotective effects by inhibiting endothelial injury and by ameliorating neuronal damage in brain ischemia. Recently, it was reported that edaravone could alleviate the pathology and cognitive deficits of Alzheimer's disease patients. However, its relevance to vascular dementia (VaD) is not clear. In this study, we partially occluded the bilateral carotid arteries of rats surgically to induce chronic cerebral hypoperfusion (CCH), a well-known rat model of VaD...
November 17, 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/27860340/nitrogen-doped-mesoporous-carbon-encapsulated-moo2-nanobelts-as-a-high-capacity-and-stable-host-for-lithium-ion-storage
#11
Xianjun Tan, Chuanfeng Cui, Shiqun Wu, Bocheng Qiu, Lingzhi Wang, Jinlong Zhang
N-doped mesoporous carbon capped MoO2 nanobelts (donated as MoO2@NC) were synthesized and applied to lithium ion storage. Thanks to the stable core-shell structured framework and conductive mesoporous carbon matrix, the as-prepared MoO2@NC show high specific capacity of around 700 mA h g-1 at a current of 0.5 A g-1, excellent cycling stability up to 100 cycles, and superior rate performance. The N-doped mesoporous carbon can greatly improve the conductivity and provide uninhibited conducting pathways for fast charge transfer and transport...
November 18, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27834052/effect-of-land-use-pattern-change-from-paddy-soil-to-vegetable-soil-on-the-adsorption-desorption-of-cadmium-by-soil-aggregates
#12
Qiu Zhang, Zhongwu Li, Bin Huang, Ninglin Luo, Lingzhi Long, Mei Huang, Xiuqing Zhai, Guangming Zeng
The influence of land use change from paddy soil to vegetable soil on the adsorption-desorption behavior of Cd in soil aggregates and the variation in soil properties were investigated. The vegetable soil was characterized by lower pH, organic matter content, cation exchange capacity (CEC), free iron oxides, manganese oxides, and catalase activity and higher urease activity compared with the paddy soil. In the isothermal adsorption and desorption experiments, the adsorption characteristics of Cd of the two soils could be well described by Langmuir and Freundlich equations...
November 11, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27833099/proteomic-characterization-of-the-world-trade-center-dust-activated-mdig-and-c-myc-signaling-circuit-linked-to-multiple-myeloma
#13
Kai Wu, Lingzhi Li, Chitra Thakur, Yongju Lu, Xiangmin Zhang, Zhengping Yi, Fei Chen
Several epidemiological studies suggested an increased incidence rate of multiple myeloma (MM) among first responders and other individuals who exposed to World Trade Center (WTC) dust. In this report, we provided evidence showing that WTC dust is potent in inducing mdig protein and/or mRNA in bronchial epithelial cells, B cells and MM cell lines. An increased mdig expression in MM bone marrow was observed, which is associated with the disease progression and prognosis of the MM patients. Through integrative genomics and proteomics approaches, we further demonstrated that mdig directly interacts with c-myc and JAK1 in MM cell lines, which contributes to hyperactivation of the IL-6-JAK-STAT3 signaling important for the pathogenesis of MM...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27800128/the-distribution-of-syphilis-among-inpatients-in-wenzhou-china-a-hospital-based-study
#14
Ke Xu, Shengying Chi, Bin Chen, Lingzhi Chen, Dongyun Zheng
BACKGROUND: The high prevalence of syphilis among inpatients is an important concern in clinical settings. Thus, a better understanding of the serological test would be valuable. OBJECTIVES: We analyzed the serological test results for syphilis among the inpatients in Wenzhou central hospital, China, to estimate the distribution of syphilis this Chinese population. PATIENTS AND METHODS: The blood samples of 81946 inpatients at the hospital from January 2010 to December 2012 were collected and retrospectively analyzed...
August 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27775633/improved-production-and-antitumor-properties-of-triterpene-acids-from-submerged-culture-of-ganoderma-lingzhi
#15
Xiao-Ling Wang, Zhong-Yang Ding, Gao-Qiang Liu, Hailong Yang, Guo-Ying Zhou
Triterpene acids (TAs) are the major bioactive constituents in the medicinal fungus Ganoderma lingzhi. However, fermentative production of TAs has not been optimized for commercial use, and whether the TAs isolated from G. lingzhi submerged culture mycelia possess antitumor activity needs to be further proven. In this study, enhanced TA yield and productivity were attained with G. lingzhi using response surface methodology. The interactions of three variables were studied using a Box-Benhnken design, namely initial pH, dissolved oxygen (DO) and fermentation temperature...
October 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27770887/electrodeposited-reduced-graphene-oxide-incorporating-polymerization-of-l-lysine-on-electrode-surface-and-its-application-in-simultaneous-electrochemical-determination-of-ascorbic-acid-dopamine-and-uric-acid
#16
Dongdong Zhang, Lingzhi Li, Weina Ma, Xia Chen, Yanmin Zhang
This paper demonstrates a novel strategy for the construction of a graphene hybrid composites film, which was fabricated by electrodeposited reduced graphene oxide (ERGO) incorporating polymerization of l-lysine (PLL) onto glassy carbon electrode (GCE). Here we show that graphene films can be prepared on electrodes directly from GO dispersions by one-step electrodeposition technique based on electropolymerized PLL as a positively charged polymer interface to adsorb negatively charged GO nanosheets through electrostatic attraction...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27766179/construction-of-a-turn-off-on-off-fluorescent-system-based-on-competitive-coordination-of-cu-2-between-6-7-dihydroxycoumarin-and-pyrophosphate-ion-for-sensitive-assay-of-pyrophosphatase-activity
#17
Lingzhi Zhao, Liu Zhao, Yanqing Miao, Chunye Liu, Chenxiao Zhang
The detection of pyrophosphatase (PPase) activity is of great significance in diagnosing diseases and understanding the function of PPase-related biological events. This study constructed a turn off-on-off fluorescent system for PPase activity assay based on PPase-regulated competitive coordination of Cu(2+) between a water-soluble fluorescent probe 6,7-dihydroxycoumarin (DHC) and pyrophosphate (PPi). The probe DHC can coordinate with Cu(2+) and consequently display on-off type fluorescence response. Furthermore, the in situ formed nonfluorescent Cu(2+)-DHC complex can act as an effective off-on type fluorescent probe for sensing PPi due to the higher coordination reactivity between Cu(2+) and PPi than that between Cu(2+) and DHC...
2016: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/27699276/prl3-zumab-a-first-in-class-humanized-antibody-for-cancer-therapy
#18
Min Thura, Abdul Qader Omer Al-Aidaroos, Wei Peng Yong, Koji Kono, Abhishek Gupta, You Bin Lin, Kousaku Mimura, Jean Paul Thiery, Boon Cher Goh, Patrick Tan, Ross Soo, Cheng William Hong, Lingzhi Wang, Suling Joyce Lin, Elya Chen, Sun Young Rha, Hyun Cheol Chung, Jie Li, Sayantani Nandi, Hiu Fung Yuen, Shu-Dong Zhang, Yeoh Khay Guan, Jimmy So, Qi Zeng
Novel, tumor-specific drugs are urgently needed for a breakthrough in cancer therapy. Herein, we generated a first-in-class humanized antibody (PRL3-zumab) against PRL-3, an intracellular tumor-associated phosphatase upregulated in multiple human cancers, for unconventional cancer immunotherapies. We focused on gastric cancer (GC), wherein elevated PRL-3 mRNA levels significantly correlated with shortened overall survival of GC patients. PRL-3 protein was overexpressed in 85% of fresh-frozen clinical gastric tumor samples examined but not in patient-matched normal gastric tissues...
June 16, 2016: JCI Insight
https://www.readbyqxmd.com/read/27677381/prevalence-and-risk-factors-for-asthma-among-children-aged-0-14-years-in-hangzhou-a-cross-sectional-survey
#19
Dan Xu, Yingshuo Wang, Zhimin Chen, Shuxian Li, Yungai Cheng, Li Zhang, Lingzhi Zhao
BACKGROUND: Asthma is a global problem. Prevalence varies among different countries and cities. We aimed to obtain the prevalence, describe the characteristics, and discover factors that may relate to asthma in Hangzhou. METHODS: This cross-sectional study was conducted in Hangzhou. The subjects were children aged 14 years and younger. A control group of non-asthma children that matched in age and sex with each asthmatic patient was also randomly selected and interviewed...
September 27, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27668228/effectiveness-of-enteral-feeding-protocol-on-clinical-outcomes-in-critically-ill-patients-a-study-protocol-for-before-and-after-design
#20
Zhongheng Zhang, Qian Li, Lingzhi Jiang, Bo Xie, Xiaowei Ji, Jiahong Lu, Ronglin Jiang, Shu Lei, Shihao Mao, Lijun Ying, Di Lu, Xiaoshui Si, Jianxin He, Mingxia Ji, Jianhua Zhu, Guodong Chen, Yadi Shao, Yinghe Xu, Ronghai Lin, Chao Zhang, Weiwen Zhang, Jian Luo, Tianzheng Lou, Xuwei He, Kun Chen, Renhua Sun
INTRODUCTION: Enteral feed is an important component of nutritional therapy in critically ill patients and underfeeding has been associated with adverse outcomes. The article developed an enteral feeding protocol and planed a before-and-after comparative trial to explore whether implementation of enteral feeding protocol was able to improve clinical outcomes. METHODS AND ANALYSIS: The study will be conducted in intensive care units (ICUs) of ten tertiary care academic centers...
August 2016: Annals of Translational Medicine
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