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https://www.readbyqxmd.com/read/28510800/structural-modulation-of-gut-microbiota-in-bama-minipigs-in-response-to-treatment-with-a-growth-promoting-agent-salbutamol
#1
Chenyang Lu, Jun Zhou, Yanyan Li, Dijun Zhang, Zuzhong Wang, Ye Li, Lingzhi Cheong, Chundan Zhang, Xiurong Su
Even though salbutamol (SAL) had remarkable effects on the enhancement of growth rate and carcass composition in different livestock species such as cattle, pigs, sheep and poultry, it was banned as a growth promoter because of its adverse effects on health. However, the specific mechanism by which salbutamol enhances growth efficiency remains unknown. In this study, Bama pigs were randomly allocated to receive salbutamol (5 mg/kg) for 30 or 60 days and were compared with untreated pigs. Pigs treated with salbutamol demonstrated enhanced growth rates and carcass composition; however, they showed deterioration in blood biochemical indices and organ development...
May 16, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28499820/he4-expression-in-lung-cancer-a-meta-analysis
#2
REVIEW
Hai Zhong, Yingying Qian, Surong Fang, Linfei Yang, Lingzhi Li, Wei Gu
BACKGROUND: The prognostic role of Human epididymis protein 4 (HE4) expression in lung cancer remains controversial. We performed this meta-analysis to assess the prognostic value of HE4 expression in lung cancer. METHODS: A systematic literature search was conducted to identify eligible studies in PubMed, Embase and Wanfang databases. The pooled hazard ratios (HRs) and their 95% confidence intervals (CIs) were used to assess the relationship. RESULTS: A total of 1412 patients from 8 studies were included in this meta-analysis...
May 9, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28498557/preparation-of-ultrathin-two-dimensional-tixta1-xsyoz-nanosheets-as-highly-efficient-photothermal-agents
#3
Hua Zhang, Chaoliang Tan, Lingzhi Zhao, Peng Yu, Ying Huang, Bo Chen, Zhuangchai Lai, Xiaoying Qi, Min Hao Goh, Xiao Zhang, Shikui Han, Xue-Jun Wu, Zheng Liu, Yanli Zhao
High-yield preparation of solution-processed ultrathin 2D metal oxide/sulfide hybrid nanosheets, i.e. TixTa1-xSyOz (x=0.71, 0.49, 0.30), was reported via our developed electrochemical Li-intercalation method using TixTa1-xS2 layered bulk crystals as precursors. The obtained TixTa1-xSyOz nanosheets are composed of amorphous metal oxide and metal sulfide components containing a few crystalline TixTa1-xS2 domains. The Ti0.71Ta0.29SyOz nanosheet exhibits strong absorbance at the near-infrared regime, giving large extinction coefficient of 54...
May 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28492630/one-step-large-scale-highly-active-g-c3n4-nanosheets-for-efficient-sunlight-driven-photocatalytic-hydrogen-production
#4
Waheed Iqbal, Bocheng Qiu, Juying Lei, Lingzhi Wang, Jinlong Zhang, Masakazu Anpo
The development of highly active, cost-effective, environmentally friendly and stable g-C3N4 based photocatalysts for H2 evolution is one of the most anticipated potential pathways for future hydrogen utilization. Herein, a facile gaseous bubble template approach was designed to prepare large-scale thin g-C3N4 nanosheets (g-C3N4 NSs) using melamine and ammonium sulphate as the bubble template. Through distinctive structural improvements for a large bandgap, excellent electron mobility, prolonged lifetime of the photogenerated charge carriers and a high specific surface area with highly accessible potential reaction sites, the as-synthesized g-C3N4 NSs demonstrated a high photocatalytic hydrogen evolution rate of 9871 μmol h(-1) g(-1) and efficient photocatalytic degradation of Rhodamine B (RhB) and phenol under simulated solar light irradiation...
May 11, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28463820/prevalence-and-risk-factors-of-agitation-in-newly-hospitalized-schizophrenia-patients-in-china-an-observational-survey
#5
Weifeng Mi, Suzhen Zhang, Qi Liu, Fude Yang, Yong Wang, Tao Li, Qiyi Mei, Hongbo He, Zhiyu Chen, Zhonghua Su, Tiebang Liu, Shiping Xie, Qingrong Tan, Jinbei Zhang, Congpei Zhang, Hong Sang, Wenhao Chen, Le Shi, Lingzhi Li, Ying Shi, Lihua Guo, Hongyan Zhang, Lin Lu
This multi-center observational study investigated the prevalence of agitation in newly hospitalized schizophrenia patients in China and its potential risk factors. It was performed in 2014 and covered 14 hospitals. Newly hospitalized patients with schizophrenia or suspected schizophrenia who met the diagnostic criteria of the International Statistical Classification of Diseases and Related Health Problems, 10th revision, were recruited. Agitation and related risk factors were evaluated by a questionnaire designed for the survey...
March 2, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28459381/arsenic-and-sumo-wrestling-in-protein-modification
#6
Lingzhi Li, Fei Chen
No abstract text is available yet for this article.
May 1, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28365132/exosomes-in-cancer-nanomedicine-and-immunotherapy-prospects-and-challenges
#7
REVIEW
Nicholas L Syn, Lingzhi Wang, Edward Kai-Hua Chow, Chwee Teck Lim, Boon-Cher Goh
Exosomes (versatile, cell-derived nanovesicles naturally endowed with exquisite target-homing specificity and the ability to surmount in vivo biological barriers) hold substantial promise for developing exciting approaches in drug delivery and cancer immunotherapy. Specifically, bioengineered exosomes are being successfully deployed to deliver potent tumoricidal drugs (siRNAs and chemotherapeutic compounds) preferentially to cancer cells, while a new generation of exosome-based therapeutic cancer vaccines has produced enticing results in early-phase clinical trials...
March 29, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28357404/painvision%C3%A2-apparatus-for-assessment-of-efficacy-of-pulsed-radiofrequency-combined-with-pharmacological-therapy-in-the-treatment-of-postherpetic-neuralgia-and-correlations-with-measurements
#8
RANDOMIZED CONTROLLED TRIAL
Dong Wang, Kai Zhang, ShaoLong Han, LingZhi Yu
Objective. PainVision device was a developed application for the evaluation of pain intensity. The objective was to assess the efficacy and safety of pulsed radiofrequency (PRF) combined with pharmacological therapy in the treatment of postherpetic neuralgia (PHN). We also discussed the correlation of the measurements. Method. Forty patients with PHN were randomized for treatment with PRF combined with pharmacological therapy (PRF group, n = 20) or pharmacological therapy (control group, n = 20) at postoperative 48 hours...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28353585/relationship-of-oestrogen-receptor-alpha-gene-polymorphisms-with-risk-for-benign-prostatic-hyperplasia-and-prostate-cancer-in-chinese-men
#9
Zihua Han, Lingzhi Zhang, Rujian Zhu, Lifei Luo, Min Zhu, Lilong Fan, Guanfu Wang
The relationship of oestrogen receptor with benign prostatic hyperplasia (BPH) and prostate cancer (PC) is not clear at present. This study aimed to investigate the molecular mechanism underlying the occurrence and development of BPH and prostate.Two hundred forty-four PC cases, 260 BPH patients, and 222 healthy men were recruited from Han people in China, and the oestrogen receptor alpha (ESRα) gene polymorphism (rs2234693 [PvuII] and rs9340799 [XbaI]) on intron 1 was determined. The relationship of gene polymorphism with PC and BPH was evaluated with Logistic regression, and the linkage disequilibrium and haplotyping were assessed with SHEsis software...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28346885/plasma-and-brain-pharmacokinetics-of-ganoderic-acid-a-in-rats-determined-by-a-developed-uflc-ms-ms-method
#10
Fang-Rui Cao, Bing-Xin Xiao, Li-Sha Wang, Xue Tao, Ming-Zhu Yan, Rui-Le Pan, Yong-Hong Liao, Xin-Min Liu, Qi Chang
Ganoderic acid A (GAA), an active triterpenoid of the traditional Chinese herbal medicine Lingzhi, has been reported to exhibit antinociceptive, antioxidative, and anti-cancer activities. The present study aims to establish a sensitive and rapid UPLC-MS/MS method for studying the plasma and brain pharmacokinetics of GAA in rats. The analytes were separated on a C18 column eluted with a gradient mobile phase consisting of acetonitrile and 0.1% aqueous formic acid at 0.3mL/min. The eluate was monitored by a mass detector using an MRM (m/z, 515...
March 11, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28346383/novel-antihypertensive-peptides-derived-from-adlay-coix-larchryma-jobi-l-var-ma-yuen-stapf-glutelin
#11
Bin Li, Liansheng Qiao, Lingling Li, Yanling Zhang, Kai Li, Lingzhi Wang, Yanjiang Qiao
n/a.
March 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28340703/a-ratiometric-two-photon-fluorescent-probe-for-imaging-hydrogen-sulfide-in-lysosomes
#12
Wenqi Feng, Zhiqiang Mao, Lingzhi Liu, Zhihong Liu
Hydrogen sulfide (H2S) is a kind of gaseous signalling molecule that plays pivotal role in various biological processes. So far, it is still a challenge to develop convenient and reliable methods for H2S detection in lysosomes. Herein, we developed a novel ratiometric two-photon fluorescent probe LR-H2S for imaging H2S in lysosomes. Upon the addition of H2S (using Na2S as a donor) to LR-H2S in buffer solution, the azide group is reduced to amino group and subsequently the carbamate ester is cleaved by 1,6-elimination, resulting in a fluorescence emission increase at 541nm and a concomitant emission decrease at 475nm...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28335506/a-colorimetric-sensor-for-the-highly-selective-detection-of-sulfide-and-1-4-dithiothreitol-based-on-the-in-situ-formation-of-silver-nanoparticles-using-dopamine
#13
Lingzhi Zhao, Liu Zhao, Yanqing Miao, Chunye Liu, Chenxiao Zhang
Hydrogen sulfide (H₂S) has attracted attention in biochemical research because it plays an important role in biosystems and has emerged as the third endogenous gaseous signaling compound along with nitric oxide (NO) and carbon monoxide (CO). Since H₂S is a kind of gaseous molecule, conventional approaches for H₂S detection are mostly based on the detection of sulfide (S(2-)) for indirectly reflecting H₂S levels. Hence, there is a need for an accurate and reliable assay capable of determining sulfide in physiological systems...
March 20, 2017: Sensors
https://www.readbyqxmd.com/read/28322148/effects-of-exogenous-salicylic-acid-on-ganoderic-acid-biosynthesis-and-the-expression-of-key-genes-in-the-ganoderic-acid-biosynthesis-pathway-in-the-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes
#14
Peng-Fei Cao, Chen-Gao Wu, Zhi-Hao Dang, Liang Shi, Ai-Liang Jiang, Ang Ren, Ming-Wen Zhao
We demonstrate herein that salicylic acid (SA) can enhance ganoderic acid (GA) accumulation in the lingzhi or reishi medicinal mushroom Ganoderma lucidum. Following treatment with different concentrations of SA, the GA content was increased 22.72% to 43.04% compared with the control group. When the fungi were treated with 200 μmol/L SA at different times, the GA content was improved 10.21% to 35.24% compared with the control group. By choosing the optimum point based on response surface methodology, the GA content could be increased up to 229...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28322142/enhanced-release-of-immunostimulating-%C3%AE-1-3-glucan-by-autodigestion-of-the-lingzhi-medicinal-mushroom-ganoderma-lingzhi-agaricomycetes
#15
Yuina Ishimoto, Ken-Ichi Ishibashi, Daisuke Yamanaka, Yoshiyuki Adachi, Hisatomi Ito, Kentaro Igami, Toshitsugu Miyazaki, Naohito Ohno
Ganoderma lingzhi is a widely used medicinal mushroom that has antioxidative effects, ameliorates insulin resistance, and improves quality of life in patients with metabolic syndrome. Potentiation of immunity is also a major function of G. lingzhi, and this has been applied in patients with cancer. Supplementing G. lingzhi into foods reduced the metastasis of cancer cells. β-l,3-glucan is an important bioactive component of G. lingzhi. In this study we enhanced the solubilization ofimmunostimulating β-l,3-glucan by autodigestion of G...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28245473/anti-fibrosis-effect-of-relaxin-and-spironolactone-combined-on-isoprenaline-induced-myocardial-fibrosis-in-rats-via-inhibition-of-endothelial-mesenchymal-transition
#16
Jiejie Cai, Xiao Chen, Xingxing Chen, Lingzhi Chen, Gaoshu Zheng, Hao Zhou, Xi Zhou
BACKGROUND: The effect of relaxin and spironolactone combined on myocardial fibrosis has not been reported. Thus, we investigated the effect of the combined therapy on isoprenaline-induced myocardial fibrosis and the mechanism. METHODS: Rats were injected subcutaneously with isoprenaline to induce myocardial fibrosis and underwent subcutaneous injection with relaxin (2 µg·kg-1·d-1) and given a gavage of spironolactone (30 mg·kg-1·d-1) alone or combined for 14 days...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28224891/side-chain-crystallization-in-alkyl-substituted-cellulose-esters-and-hydroxypropyl-cellulose-esters
#17
Xi Chen, Nan Zheng, Qiao Wang, Lingzhi Liu, Yongfeng Men
The differences in side chain crystallization behavior between cellulose esters (CEs) and hydroxypropyl cellulose esters (HPCEs) were systematically investigated by a combination of differential scanning calorimetry (DSC) and small and wide-angle X-ray scattering techniques. DSC investigation indicated that under the same side chain length, the fusion enthalpy and the number of crystallized CH2 of CEs were smaller than HPCEs. At the same time, their d-spacing and molecular arrangements were also different from each other...
April 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28213900/c-h-direct-arylated-6h-indolo-2-3-b-quinoxaline-derivative-as-a-thickness-dependent-hole-injection-layer
#18
Dai Dong, Da Fang, Hairong Li, Caixia Zhu, Xianghua Zhao, Jiewei Li, Lingzhi Jin, Linghai Xie, Lin Chen, Jianfeng Zhao, Hongmei Zhang, Wei Huang
A novel perfluoro-1,4-phenylenyl 6H-indolo[2,3-b]quinoxaline derivative (TFBIQ) was designed and synthesized by using a C-H direct arylation method. The optoelectrical properties of the obtained TFBIQ were fully characterized by UV/Vis spectroscopy, photoluminescence spectroscopy, cyclic voltammetry, and a group of Alq3 -based green organic light-emitting diodes (OLEDs). Device A, which used 0.5 nm-thick TFBIQ as the interfacial modification layer, exhibited the five best advantages of device performance including a minimum turn-on voltage as low as 3...
February 18, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28157715/combined-use-of-irinotecan-with-histone-deacetylase-inhibitor-belinostat-could-cause-severe-toxicity-by-inhibiting-sn-38-glucuronidation-via-ugt1a1
#19
Lingzhi Wang, Chong En Linus Chan, Andrea Li-Ann Wong, Fang Cheng Wong, Siew Woon Lim, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Lawrence Soon-U Lee, Ross Soo, Wei Peng Yong, Soo Chin Lee, Paul Chi-Lui Ho, Gautam Sethi, Boon Cher Goh
SN-38, the active metabolite of irinotecan, and histone deacetylase inhibitors (HDACis) such as belinostat, vorinostat and panobinostat, have all been shown to be deactivated by glucuronidation via UGTs. Since they all compete for UGTs for deactivation, we aimed to investigate the inhibitory effect of various HDACis on the glucuronidation of SN-38. This inhibitory effect was determined by measuring the formation rate of SN-38 glucuronide after SN-38 incubation with human recombinant UGT1A isoforms (1A1, 1A6, 1A7 and 1A9) and pooled human liver microsomes (HLM, wild type, UGT1A1*1*28 and UGT1A1*28*28 allelic variants), with and without HDACis...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28143662/screening-and-analysis-of-potential-anti-tumor-components-from-the-stipe-of-ganoderma-sinense-using-high-performance-liquid-chromatography-time-of-flight-mass-spectrometry-with-multivariate-statistical-tool
#20
Kar-Man Chan, Grace Gar-Lee Yue, Ping Li, Eric Chun-Wai Wong, Julia Kin-Ming Lee, Edward J Kennelly, Clara Bik-San Lau
According to Chinese Pharmacopoeia 2015 edition, Ganoderma (Lingzhi) is a species complex that comprise of Ganoderma lucidum and Ganoderma sinense. The bioactivity and chemical composition of G. lucidium had been studied extensively, and it was shown to possess antitumor activities in pharmacological studies. In contrast, G. sinense has not been studied in great detail. Our previous studies found that the stipe of G. sinense exhibited more potent antitumor activity than the pileus. To identify the antitumor compounds in the stipe of G...
March 3, 2017: Journal of Chromatography. A
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