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Qiao Yang, Xiaoling Zhang, Lingzhi Li, Ruonan Zhang, Lijuan Feng, Jun Mu
Subsequent to the publication of this article, it was noted that one of the culture collection numbers given for the type strain was given in error. Consequently, in the abstract "The type strain is AT2-AT (CCTCC AB 2016296T = KCTC 52626T)." should read "The type strain is AT2-AT (CCTCC AB 2016296T = KCTC 62340T)." Likewise, in the protologue section, "The type strain is AT2-AT (= CCTCC AB 201696T = KCTC 52626T), which is a algal-associated bacterium isolated from the culture of a toxigenic marine dinoflagellate, Alexandrium minutum (Amtk-4) collected from southern Taiwan...
February 12, 2018: Antonie Van Leeuwenhoek
Xu Zhang, Lingzhi Sun
Esophageal carcinoma is a common malignancy worldwide, with a low 5-year survival rate. As the majority of cases are diagnosed at an advanced stage, there is an urgent need for an effective biomarker for early diagnosis of esophageal cancer patients. Surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS) was applied to detect the serum protein expression in esophageal cancer patients using ProteinChip software, and the results were analyzed and screened using Biomarker Patterns and SPSS16...
February 2018: Molecular and Clinical Oncology
María Soledad Vela Gurovic, Fátima R Viceconte, Marcelo T Pereyra, Maximiliano A Bidegain, María Amelia Cubitto
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Lingzhi or Reishi) is a medicinal mushroom historically used in Asian countries to treat a wide variety of diseases and prolong life. In the last years, G. lucidum has been internationally recognized as an effective adjuvant in cancer treatment. Among active components, the most recent research indicates that polysaccharides modulate the immune response favoring the recovery from toxicity of chemo and radiotherapy while triterpenes are cytotoxic to tumoral cells mainly by altering gene expression...
February 5, 2018: Journal of Ethnopharmacology
Hongyan Zhang, Yanyan Li, Chenxi Cui, Tingting Sun, Jiaojiao Han, Dijun Zhang, Chenyang Lu, Jun Zhou, Lingzhi Cheong, Ye Li, Xiurong Su
Previous studies have shown that dietary supplementation with tuna oil and algae oil can alleviate the effects of ageing on learning and memory in mouse models, but the mechanism of this effect remains unknown. This study aimed to determine whether dietary oil supplementation alters the composition of the gut microbiota during the prevention of age-related effects on cognition. Ageing mice received dietary oil supplementation continuously for 12 weeks. The supplementation was found to improve the animals' learning and cognition, and this effect was most marked in the TO200AO400 group, which received a 1:2 mixture of tuna oil and algae oil at 600 mg kg-1 day-1...
February 7, 2018: Applied Microbiology and Biotechnology
Jonathan B Rosenberg, Michael Kaplitt, Bishnu P De, Alvin Chen, Thomas Flagiello, Christiana O Salami, Eduard Pey, Lingzhi Zhao, Rodolfo Ricart Arbona, Sebastien Monette, Jonathan Dyke, Douglas Ballon, Stephen M Kaminsky, Dolan Sondhi, Gregory Petsko, Steven Paul, Ronald G Crystal
Alzheimer's disease (AD) is a progressive degenerative neurological disorder affecting nearly 1 in 9 elderly people in the United States. Population studies have shown that an inheritance of the apolipoprotein E (APOE) variant APOE4 allele increases the risk of developing AD, whereas, APOE2 homozygotes are protected from late onset AD. We hypothesized that expression of the "protective" APOE2 variant by genetic modification of the central nervous system (CNS) of APOE4 homozygotes could reverse or prevent progressive neurologic damage...
February 6, 2018: Human Gene Therapy. Clinical Development
Xiaodong Wu, Lingzhi Shi, Yang Xia, Ko-Pen Wang, Qiang Li
The description of precise intrabronchial positions for the sampling of mediastinal-hilar lymph nodes is critical to successfully perform conventional transbronchial needle aspiration. Previously published maps of mediastinal-hilar lymph nodes were primarily drawn based on experts' experience. We generated a virtual map of the most frequently sampled intrathoracic lymph nodes from an intrabronchial perspective using a virtual bronchoscopic navigation system, to assist with training in conventional transbronchial needle aspiration...
January 29, 2018: Thoracic Cancer
Lu Ouyang, Lingzhi Zhan, Jianxiao Li, Qiaoyu Zhang, Chaorong Qi, Wanqing Wu, Huanfeng Jiang
A novel palladium-catalyzed amination and nitration of ethyl vinyl ether for the construction of β-nitroamine derivatives under mild conditions has been developed. This transformation provides a new strategy for the installation of amino and nitro from aromatic amines and nitro-paraffin into alkenes. Morpholine resulted in the aza-Henry reaction, while DABCO led to the unexpected rearrangement.
January 25, 2018: Organic Letters
Meiling Zhang, Xiudan Wang, Lingzhi Han, Shuyan Niu, Chao Shi, Cuiping Ma
A strand exchange amplification (SEA) method to detect foodborne pathogen Listeria monocytogenes was developed. SEA is a novel nucleic acid amplification method that only requires one pair of primers. The specie-specific primers were designed by targeting the 16S rRNA gene and the amplification reaction was performed as short as 60 min at 61 °C. Notably, SEA method could not only detect genomic DNA but also detect RNA by one step without requiring extra reverse transcription. The result could be visualized by naked eyes so that water bath pot would be the only equipment needed...
January 16, 2018: Analytical Biochemistry
Yue Qi, Bing Deng, Xiao Guo, Shulin Chen, Jing Gao, Tianran Li, Zhipeng Dou, Haina Ci, Jingyu Sun, Zhaolong Chen, Ruoyu Wang, Lingzhi Cui, Xudong Chen, Ke Chen, Huihui Wang, Sheng Wang, Peng Gao, Mark H Rummeli, Hailin Peng, Yanfeng Zhang, Zhongfan Liu
Plasma-enhanced chemical vapor deposition (PECVD) is an applicable route to achieve low-temperature growth of graphene, typically shaped like vertical nanowalls. However, for transparent electronic applications, the rich exposed edges and high specific surface area of vertical graphene (VG) nanowalls can enhance the carrier scattering and light absorption, resulting in high sheet resistance and low transmittance. Thus, the synthesis of laid-down graphene (LG) is imperative. Here, a Faraday cage is designed to switch graphene growth in PECVD from the vertical to the horizontal direction by weakening ion bombardment and shielding electric field...
January 10, 2018: Advanced Materials
Pengxian Tao, Xiangyang Wu, Lingzhi Zhao, Feng Wang, Qi Xia, Yan Peng, Bingren Gao
To explore the changes of blood viscosity in high-intensity alternating magnetic field and the mechanisms.
 Methods: Five adult sheep were randomly selected and the blood samples were placed in high-intensity alternating magnetic field. Before and after exposure, the blood samples were taken and divided into 2 groups: a control group and a magnetic field group. The blood rheology and transmission electron microscopy (TEM) were performed.
 Results: Compared to the control group, the high shear viscosity of whole blood was decreased in the magnetic field group (P<0...
December 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Yuhan Ma, Huaqi He, Jingzhu Wu, Chunyang Wang, Kuanglin Chao, Qing Huang
Ganoderma lingzhi (G. lingzhi), G. sinense, G. applanatum, etc. belongs to the Ganoderma genus of polypore mushrooms which contain rich polysaccharides valuable for nutrition and positive medicinal effects. In order to evaluate polysaccharide content in Ganoderma mycelia obtained in the fermentation process quickly and accurately, in this work we employed infrared spectroscopy to examine different Ganoderma stains of samples from diversified sources. Through mid-infrared (mid-IR) spectroscopy, we could identify the most relevant spectral bands required for polysaccharide evaluation, and through near-infrared (NIR) spectroscopy, we could establish the quantification model for making satisfactory prediction of polysaccharide ingredient content...
January 8, 2018: Scientific Reports
Lingzhi Wang, Nicholas Li-Xun Syn, Vinod Vijay Subhash, Yijia Any, Win Lwin Thuya, Esther Cheow, Liren Kong, Fenggang Yu, Praveen C Peethala, Andrea Li-Ann Wong, Hirpara J Laljibhai, Arunachalam Chinnathambi, Pei Shi Ong, Paul Chi-Lui Ho, Gautam Sethi, Wei Peng Yong, Boon Cher Goh
Accumulating evidence has implicated the aberrant regulation of histone deacetylases (HDACs) as a nexus for multiple cancer hallmarks and in mediating tumor adaptation and resistance to genotoxic chemotherapy, suggesting a rational pairing of HDAC inhibitors with DNA damaging chemotherapeutic agents in the treatment of human malignancies. Here we report that panobinostat (LBH589), a potent pan-HDAC inhibitor, effectively curbed the proliferation of non-small cell lung cancer (NSCLC) cell lines A549, Calu-1, H226, H460, H838 and SKMES-1 at IC50 concentrations between 4 and 31 nmol/L via pleiotropic mechanisms, including crosstalk with EGFR signal transduction cascades...
January 3, 2018: Cancer Letters
Lingzhi Kong, Shaohui Wang, Xiuping Liu, Liang Li, Michael Zeeman, Jun Yan
Auditory learning induces frequency-specific plasticity in the auditory cortex. Both the auditory cortex and thalamus are involved in the cortical plasticity; however, the precise role of the intracortical circuity remains unclear until the contributions of the thalamocortical inputs are controlled. Here, we induced cortical plasticity by local activation of the primary auditory cortex (AI) via intracortical electrical stimulation (ES) in C57 mice and found a similar pattern of cortical plasticity was induced by ESAI when the auditory thalamus was inactivated or remained active during the ESAI...
December 20, 2017: Neuroscience Letters
Kishore Banik, Choudhary Harsha, Devivasha Bordoloi, Bethsebie Lalduhsaki Sailo, Gautam Sethi, Hin Chong Leong, Frank Arfuso, Srishti Mishra, Lingzhi Wang, Alan P Kumar, Ajaikumar B Kunnumakkara
Natural compounds have enormous biological and clinical activity against dreadful diseases such as cancer, as well as cardiovascular and neurodegenerative disorders. In spite of the widespread research carried out in the field of cancer therapeutics, cancer is one of the most prevalent diseases with no perfect treatment till date. Adverse side effects and the development of chemoresistance are the imperative limiting factors associated with conventional chemotherapeutics. For this reason, there is an urgent need to find compounds that are highly safe and efficacious for the prevention and treatment of cancer...
December 12, 2017: Cancer Letters
Bin Zhang, Yushan Cui, Lingzhi Wang, Liang Zhao, Changchun Hou, Qiang Zeng, Zushan Zhang, Jingwen Yu, Yang Zhao, Junyan Nie, Xuemin Chen, Aiguo Wang, Hongliang Liu
To date, there are many people residing in areas with high levels of iodide in water. Our previous epidemiological study showed that exposure to high iodine in drinking water significantly reduced the intelligence of children although the mechanisms remain unclear. To explore whether high concentrations of iodide may cause cytotoxic effect and the role of autophagy in the high iodide-induced apoptosis, human neuroblastoma cells (SH-SY5Y cells) were exposed to high concentrations of iodide. Morphological phenotypes, cell viability, Hoechst 33258 staining, the expression levels of apoptosis and autophagy-related proteins were detected...
December 11, 2017: Toxicology Letters
Qiao Yang, Xiaoling Zhang, Lingzhi Li, Ruonan Zhang, Lijuan Feng, Jun Mu
During an investigation of the biodiversity of the cultivable bacterial community associated with paralytic shellfish poisoning toxin-producing marine dinoflagellate, Alexandrium minutum a novel algal-associated bacterium, designated strain AT2-AT was isolated. 16S rRNA gene sequence similarity analysis showed that the strain is a member of the genus Ponticoccus, with high sequence similarity to Ponticoccus litoralis DSM 18986T (97.9%) and Ponticoccus lacteus JCM 30379T (96.0%). However, based on the data obtained for the physiological and biochemical characteristics, and low level of DNA-DNA relatedness analysis, the strain could be genotypically and phenotypically differentiated from two type strains of the genus Ponticoccus...
December 12, 2017: Antonie Van Leeuwenhoek
Fenggang Yu, Yanan Lu, Lin Tao, Yan-Yi Jiang, De-Chen Lin, Lingzhi Wang, Fredrik Petersson, Hironori Yoshiyama, Phillip H Koeffler, Boon-Cher Goh, Kwok Seng Loh
Nasopharyngeal carcinoma (NPC) is an invasive cancer with particularly high incidence in Southern China and Southeast Asia. The study of NPC is greatly hampered by the lack of reliable cell lines due to the loss of EBV genome and HeLa cell contamination. Conditional reprogramming (CR) cell culture technique has been reported for rapid and efficient establishment of patient-derived normal and tumor cell cultures. The purpose of this study was to assess this method to culture NPC patient-derived primary tumor cells...
December 12, 2017: Scientific Reports
Viktor Papp, Bálint Dima, Solomon P Wasser
The scientific name Ganoderma lucidum has long been used in the global medicinal mushroom market, and many publications have proven its pharmacological properties and chemical components. Although several Ganoderma species have been described worldwide as having morphology considerably similar to that of G. lucidum s. str., this binomial is still the most frequently used in pharmacological studies. However, the use of particularly divergent nomenclature has caused major difficulties in the evaluation of the results of pharmacological studies...
2017: International Journal of Medicinal Mushrooms
Anuja Bhardwaj, Payal Gupta, Navin Kumar, Jigni Mishra, Ajai Kumar, Rajput Rakhee, Kshipra Misra
This article presents a comparative gas chromatography (GC)-mass spectrometry (MS)-based metabolomic analysis of mycelia and fruiting bodies of the medicinal mushroom Ganoderma lucidum. Three aqueous extracts-mycelia, fruiting bodies, and a mixture of them-and their sequential fractions (methanolic and ethyl acetate), prepared using an accelerated solvent extractor, were characterized by GC-MS to determine volatile organic compounds and by high-performance thin-layer chromatography to quantify ascorbic acid, a potent antioxidant...
2017: International Journal of Medicinal Mushrooms
Chan Kam Seng, Noorlidah Abdullah, Norhaniza Aminudin
Amauroderma rugosum fruiting bodies possess excellent cardiovascular benefits, including antioxidative, antihyperlipidemic, antihypertensive, antiinflammatory, anti-platelet aggregation, and antithrombotic effects. In this article, we describe our investigations of the in vitro antioxidant activity and in vitro antiatherosclerotic potential through inhibitory effects on low-density lipoprotein (LDL), LDL peroxidation, and 3-hydroxy3-methylglutaryl-coenzyme A (HMG-CoA) reductase catalytic activity using various fruiting body extracts partitioned with an organic solvent...
2017: International Journal of Medicinal Mushrooms
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