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Toshinori Nakagawa, Qinchang Zhu, Sonam Tamrakar, Yhiya Amen, Yasuhiro Mori, Hiroto Suhara, Shuhei Kaneko, Hiroko Kawashima, Kotaro Okuzono, Yoshiyuki Inoue, Koichiro Ohnuki, Kuniyoshi Shimizu
Ganoderma lingzhi is a traditional medicinal mushroom, and its extract contains many bioactive compounds. Triterpenoids and polysaccharides are the primary bioactive components that contribute to its medicinal properties. In this study, we quantified 18 triterpenoids, total triterpenoid content and total polysaccharide content in the ethanol and water extracts of G. lingzhi at different growth stages. Triterpenoids were quantified by liquid chromatograph-tandem mass spectrometry in the multiple-reaction-monitoring mode...
April 20, 2018: Journal of Natural Medicines
Li-Feng Li, Hong-Bing Liu, Quan-Wei Zhang, Zhi-Peng Li, Tin-Long Wong, Hau-Yee Fung, Ji-Xia Zhang, Su-Ping Bai, Ai-Ping Lu, Quan-Bin Han
Both Ganoderma lucidum (GL) and G. sinense (GS) are used as Lingzhi in China. Their functions are assumed to mainly derive from triterpenes and polysaccharides; however, the two species have very different triterpenes profiles, if this was the case, then the bioactivity of these two species should differ. Instead, could the polysaccharides be similar, contributing to the shared therapeutic basis? In this study, two main polysaccharide fractions from different batches of GL and GS were systematically compared by a series of chemical and biological experiments...
April 18, 2018: Scientific Reports
Nicholas L Syn, Pei Li Lim, Li Ren Kong, Lingzhi Wang, Andrea Li-Ann Wong, Chwee Ming Lim, Thomas Kwok Seng Loh, Gerhard Siemeister, Boon Cher Goh, Wen-Son Hsieh
In addition to their canonical roles in regulating cell cycle transition and transcription, cyclin-dependent kinases (CDKs) have been shown to coordinate DNA damage response pathways, suggesting a rational pairing of CDK inhibitors with genotoxic chemotherapeutic agents in the treatment of human malignancies. Here, we report that roniciclib (BAY1000394), a potent pan-CDK inhibitor, displays promising anti-neoplastic activity as a single agent and potentiates cisplatin lethality in preclinical nasopharyngeal carcinoma (NPC) models...
2018: Signal Transduction and Targeted Therapy
Dijun Zhang, Jiaojiao Han, Yanyan Li, Bei Yuan, Jun Zhou, Lingzhi Cheong, Ye Li, Chenyang Lu, XiuRong Su
To discern whether tuna oil modulates the expression of brain proteins and the gut microbiota structure during aging induced by D-galactose, we generated an aging mouse model with D-galactose treatment, and the mice showed aging and memory deterioration symptoms according to physiological and biochemical indices. Treatment with different doses of tuna oil alleviated the symptoms, the high dose showed a better effect. Subsequently, brain proteomic analysis showed the differentially expressed proteins were involved in damaged synaptic system repairment and signal transduction system enhancement...
April 15, 2018: Journal of Agricultural and Food Chemistry
Chunyang Zhang, Lingzhi Chen, Yingjie Zhu, Zisheng Guan
This paper reports inverted pyramid microstructure-based single-crystalline silicon (sc-Si) solar cell with a conversion efficiency up to 20.19% in standard size of 156.75 × 156.75 mm2 . The inverted pyramid microstructures were fabricated jointly by metal-assisted chemical etching process (MACE) with ultra-low concentration of silver ions and optimized alkaline anisotropic texturing process. And the inverted pyramid sizes were controlled by changing the parameters in both MACE and alkaline anisotropic texturing...
April 3, 2018: Nanoscale Research Letters
Surya Sudheer, Ibrahim Alzorqi, Asgar Ali, Poh Guat Cheng, Yasmeen Siddiqui, Sivakumar Manickam
This study investigates the cultivation of Ganoderma lucidum using different agricultural biomasses from Malaysia. Five different combinations of rubber wood sawdust, empty fruit bunch fiber, and mesocarp fiber from oil palm, alone and in combination, were used to cultivate G. lucidum. Although all the substrate combinations worked well to grow the mushroom, the highest biological efficiency was obtained from the combination of empty fruit bunch fiber with sawdust. A total yield of 27% was obtained from empty fruit bunch fiber with sawdust, followed by sawdust (26%), empty fruit bunch fiber (19%), mesocarp fiber with sawdust (19%), and mesocarp fiber (16%)...
2018: International Journal of Medicinal Mushrooms
Chunye Liu, Jingshu Zhang, Xuejiao Zhang, Lingzhi Zhao, Shuang Li
Enantiomeric separations of the adrenergic compounds adrenaline, noradrenaline, and isoprenaline were studied. Electromigrative separations were performed in uncoated fused silica capillaries using streptomycin-modified gold nanoparticles (ST-AuNPs) as an additive to the background electrolyte. The ST-AuNPs are shown to serve as an effective chiral selector. The modified AuNPs were characterized in terms of size and zeta potential, and by IR and UV-vis spectra. The effects of ST-AuNP concentration, pH value, temperature, and separation voltage on the separations were systematically studied...
March 19, 2018: Mikrochimica Acta
Leina Dou, Bingxin Zhao, Tong Bu, Wentao Zhang, Qiong Huang, Lingzhi Yan, Lunjie Huang, Yanru Wang, Jianlong Wang, Daohong Zhang
Small molecules are difficult to detect by conventional gold lateral flow assay (GLFA) sensitively because the test system must satisfy the conflict requirements between enough signal intensity and limited antibody (Ab) amount. In this work, a paired labels recognition (PLR)-based biosensor was designed by utilizing the specific binding of Ab and secondary antibody (anti-Ab) to enhance signal intensity and reduce antibody amount applied in small molecule detection. The PLR amplification system is fabricated by self-assembling the common detection probe, Au-labeled Ab (Au-Ab), and the signal booster, Au-labeled anti-Ab (Au-anti-Ab)...
March 28, 2018: Analytical and Bioanalytical Chemistry
Yanhui Lou, Huanhuan Jiang, Zhumei Cui, Xiangyu Wang, Lingzhi Wang, Yi Han
High‑grade ovarian serous cancer is known for its high rates of invasion and metastasis, and resultant high mortality rate. Therefore, research concerning biomarkers and underlying molecular mechanisms of high‑grade ovarian serous cancer progression and prognosis are urgently required. Long non‑coding RNAs (lncRNAs) have been the subject of an increasing number of studies, and certain lncRNAs have been demonstrated to serve an important function in the development and progression of various cancers, including HOX transcript antisense RNA, competing endogenous lncRNA 2 for microRNA let‑7b, urothelial cancer associated 1, and H19, imprinted maternally expressed transcript (non‑protein coding)...
March 23, 2018: International Journal of Molecular Medicine
Zhengchao Lv, Lingzhi Gao, Chuanxu Cheng, Wei Niu, Jian-Li Wang, Liang Xu
Franchetine, a unique 7,17-seco type of norditerpenoid alkaloid, possesses a highly congested polycyclic architecture coupled with nine stereogenic centers. Here we present an efficient synthetic approach for the intact hexacyclic framework of franchetine from the known tricyle 16 in 20 steps. The synthesis features a diastereoselective 6-exo-tet radical cyclization for construction of ring A and a unique oxidative Wagner-Meerwein-type rearrangement to realize the functionalized [3.2.1] bridging ring CD.
March 23, 2018: Chemistry, An Asian Journal
Mingna Liao, Qilun Zhang, Fengling Tang, Zhiwei Xu, Xin Zhou, Youpeng Li, Yali Zhang, Chenghao Yang, Qiang Ru, Lingzhi Zhao
The synthesis of nanosized CoO anodes with unique morphologies via a hydrothermal method is investigated. By adjusting the pH values of reaction solutions, nanoflakes (CoO-NFs) and nanoflowers (CoO-FLs) are successfully located on copper foam. Compared with CoO-FLs, CoO-NFs as anodes for lithium ion batteries present ameliorated lithium storage properties, such as good rate capability, excellent cycling stability, and large CoO nanoflakes; CoO nanoflowers; anodes; binder free; lithium ion batteriesreversible capacity...
March 22, 2018: Nanomaterials
Kai Wang, Chenan Guan, Chenyan Fang, Xiaoxiao Jin, Junhui Yu, Yuquan Zhang, Lingzhi Zheng
Forkhead box (FOX) A1 is a member of the FOX family of transcription factors, which serve a function in numerous types of tumor. The present study assessed the potential role of FOXA1 in human epithelial ovarian carcinoma (EOC). Total RNA was isolated from 16 fresh-frozen EOC tumors with paired corresponding non-malignant ovarian epithelium tissues, and FOXA1 expression was analyzed using reverse transcription-quantitative polymerase chain reaction. Immunohistochemical analysis was performed to evaluate FOXA1 expression in 110 epithelial ovarian carcinoma tissue specimens (including 80 serous papillary adenocarcinoma, 9 clear cell carcinoma, 12 endometrioid adenocarcinoma, 5 mucinous carcinoma and 4 transitional cell carcinoma specimens), 24 benign ovarian tumor surface epithelium tissues and 10 normal ovarian tissue samples...
April 2018: Oncology Letters
Na Li, Deli Lu, Jinlong Zhang, Lingzhi Wang
Yolk-shell structured C@Li4 Ti5 O12 microspheres composed of carbon core (ca. 500 nm) and sea urchin-like Li4 Ti5 O12 shell (ca. 400-500 nm) are formed by hydrothermally treating the core-shell structured C@TiO2 in the EtOH/H2 O solution of LiOH and calcining it in N2 atmosphere. Yolk-shell structured TiO2 -type lithium ion sieve is further transformed from C@Li4 Ti5 O12 through the acid treatment, which have a high specific surface area of 201.74 m2 /g. The composite shows adsorption capacity towards Li+ proportional to the pH value in the range of 7-13...
February 10, 2018: Journal of Colloid and Interface Science
Cuiping Ma, Hao Jing, Pansong Zhang, Lingzhi Han, Meiling Zhang, Fuxin Wang, Shuyan Niu, Chao Shi
A one-step, rapid, and visual method was developed for the detection of RNA viruses and a few copies of the Zika RNA virus were directly detected within 25 min by naked-eye observation. This method will prove to be promising for point-of-care testing in out-of-lab and inconvenient settings.
March 8, 2018: Chemical Communications: Chem Comm
Ming Chen, Lingzhi Li, Haiqiang Wu, Lingxiang Pan, Shiwu Li, Bairong He, Haoke Zhang, Jing Zhi Sun, Anjun Qin, Ben Zhong Tang
Polymers with aggregation-induced emission (AIE) characteristics have aroused tremendous interest because of their potential applications in large-area flexible display and luminescent self-assembling, and as stimuli-responsive and porous materials. However, the design of AIE-active polymers is always not as easy as that of small molecules because their properties are hard to predict. In some cases, the polymers prepared from the AIE-active monomers show the aggregation-caused quenching (ACQ) instead of AIE effect...
March 7, 2018: ACS Applied Materials & Interfaces
Lingzhi Zhang, Zhiwei Jiang, Shan Fang, Yajun Huang, Dahai Yang, Qiyao Wang, Yuanxing Zhang, Qin Liu
Many bacterial pathogens inject effectors directly into host cells to target a variety of host cellular processes and promote bacterial dissemination and survival. Identifying the bacterial effectors and elucidating their functions are central to understanding the molecular pathogenesis of these pathogens. Edwardsiella piscicida is a pathogen with a wide host range, and very few of its effectors have been identified to date. Here, based on the genes significantly regulated by macrophage infection, we identified 25 intracellular translocation-positive candidate effectors, including all five previously reported effectors, namely EseG, EseJ, EseH, EseK, and EvpP...
2018: Frontiers in Cellular and Infection Microbiology
Feihui Li, Lingzhi Li, Wei Wang, Jianping Gao
A facile one-pot method for the formation of MoO2 /RGO has been established using Mo particles as both the reductant for graphene oxide (GO) and as the Mo source. The Mo powder efficiently reduced the GO under acidic conditions to give reduced GO (RGO) and Mo ions. These ions were then transformed into MoO2 and MoO2 /RGO composites were formed by tuning the pH of the solution. Other variables such as reaction time and Mo:GO weight ratio were also investigated. The MoO2 /RGO composite prepared at 3:1 (Mo:GO, called MoO2 /RGO3 ) had the best electrochemical performance for the oxygen reduction reaction (ORR) in alkaline medium...
November 2, 2017: Journal of Colloid and Interface Science
Dorothy H J Cheong, Frank Arfuso, Gautam Sethi, Lingzhi Wang, Kam Man Hui, Alan Prem Kumar, Thai Tran
Escin is a mixture of triterpenoid saponins extracted from the horse chestnut tree, Aesculus hippocastanum. Its potent anti-inflammatory and anti-odematous properties makes it a choice of therapy against chronic venous insufficiency and odema. More recently, escin is being actively investigated for its potential activity against diverse cancers. It exhibits anti-cancer effects in many cancer cell models including lung adenocarcinoma, hepatocellular carcinoma and leukemia. Escin also attenuates tumor growth and metastases in various in vivo models...
February 20, 2018: Cancer Letters
Dedi Satria, Yhiya Amen, Yasuharu Niwa, Ahmed Ashour, Ahmed E Allam, Kuniyoshi Shimizu
A new lanostane-type triterpenoid, lucidumol D (1) was isolated from the fruiting bodies of Ganoderma lingzhi. Its structure was elucidated on the basis of extensive 1D- and 2D-NMR studies as well as mass spectrometry. The cytotoxicity of lucidumol D against proliferation of several cancer cells were assayed by using MTT method and the obtained result suggested selective anti-proliferative and cytotoxic effects against MCF-7, HepG2, HeLa, Caco-2, and HCT-116. In comparison to lucidumol C (2) isolated previously by our group, the structure-activity relationship indicated that carbonyl function at C-11 is necessary to enhance the cytotoxicity...
February 19, 2018: Natural Product Research
Qiao Yang, Xiaoling Zhang, Lingzhi Li, Ruonan Zhang, Lijuan Feng, Jun Mu
Subsequent to the publication of this article, it was noted that one of the culture collection numbers given for the type strain was given in error. Consequently, in the abstract "The type strain is AT2-AT (CCTCC AB 2016296T = KCTC 52626T)." should read "The type strain is AT2-AT (CCTCC AB 2016296T = KCTC 62340T)." Likewise, in the protologue section, "The type strain is AT2-AT (= CCTCC AB 201696T = KCTC 52626T), which is a algal-associated bacterium isolated from the culture of a toxigenic marine dinoflagellate, Alexandrium minutum (Amtk-4) collected from southern Taiwan...
February 12, 2018: Antonie Van Leeuwenhoek
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