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https://www.readbyqxmd.com/read/28830693/immunogenicity-and-safety-of-zoster-vaccine-live-administered-with-quadrivalent-influenza-virus-vaccine
#1
Myron J Levin, Ulrike K Buchwald, Julie Gardner, Jason Martin, Jon E Stek, Elizabeth Brown, Zoran Popmihajlov
OBJECTIVES: Randomized, blinded, placebo-controlled trial to evaluate the safety and immunogenicity of ZOSTAVAX™ (ZV) administered concomitantly with quadrivalent inactivated influenza vaccine (IIV4) in adults≥50years of age (NCT02519855). METHODS: Overall, 440 participants were randomized into the Concomitant Group (CG) and 442 into the Sequential Group (SG). The CG received ZV and IIV4 at separate injection sites on Day 1 and matching placebo at Week 4. The SG received placebo and IIV4 (2015-2016 influenza season) at separate injection sites on Day 1 and ZV at Week 4...
August 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28815404/neurological-presentation-of-zika-virus-infection-beyond-the-perinatal-period
#2
REVIEW
Thomas De Broucker, Alexandra Mailles, Jean-Paul Stahl
PURPOSE OF REVIEW: Our purpose was to summarize the current knowledge about the neurological presentation of Zika virus infection after the perinatal period. Other Flaviviruses infections, such as West Nile virus (WNV) or Japanese encephalitis virus (JEV), can result in neuro-invasive disease such as myelitis, encephalitis, or meningitis. We aimed at describing the specificities of ZV neurological infection. RECENT FINDINGS: The recent outbreaks demonstrated clearly the neurotropism of ZV...
August 16, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28781216/does-accounting-for-seizure-frequency-variability-increase-clinical-trial-power
#3
Daniel M Goldenholz, Shira R Goldenholz, Robert Moss, Jacqueline French, Daniel Lowenstein, Ruben Kuzniecky, Sheryl Haut, Sabrina Cristofaro, Kamil Detyniecki, John Hixson, Philippa Karoly, Mark Cook, Alex Strashny, William H Theodore, Carl Pieper
OBJECTIVE: Seizure frequency variability is associated with placebo responses in randomized controlled trials (RCT). Increased variability can result in drug misclassification and, hence, decreased statistical power. We investigated a new method that directly incorporated variability into RCT analysis, ZV. METHODS: Two models were assessed: the traditional 50%-responder rate (RR50), and the variability-corrected score, ZV. Each predicted seizure frequency upper and lower limits using prior seizures...
July 25, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28466043/scientometric-analysis-of-research-on-zika-virus
#4
Nirmal Singh
The research productivity on Zika virus (ZV) had been evaluated applying scientometrics. The different aspects of scientific literature on the subject under study accessible through 'Scopus' were explored. An advanced search was conducted in the database for 'Zika' and 'Virus' as main operators for analytical purposes. Search terms were connected using Boolean Operator 'AND' to retrieve relevant records. The search results were further filtered for journals articles. A total of 573 ZV associated records were retrieved including 6 duplicate items, after deleting which the relevant results remained 567...
September 2016: Virusdisease
https://www.readbyqxmd.com/read/28264327/-i-amazoniaseius-i-i-imparisetosus-i-n-sp-n-g-an-unusual-new-phytoseiid-mite-acari-phytoseiidae-from-the-amazon-forest
#5
Peterson R Demite, Wilton P da Cruz, James A McMURTRY, Gilberto J De Moraes
A new genus and species of the subfamily Typhlodrominae are described from the Brazilian Amazon. The main differences between this and all other phytoseiid species are the presence of two unpaired setae on dorsal shield of deutonymphs and adults, and the absence of all ZV setae. It also differs from other typhlodromine species by its relatively long J5 setae, the presence of seta J4 and the broadly rounded posterior margin of the genital shield. Thus, the unique idiosomal setal pattern of this species is here designated as 13A+x:8F+X/JV-3,4:ZV-1-3...
February 22, 2017: Zootaxa
https://www.readbyqxmd.com/read/28146192/-zika-virus-infection-in-pregnancy-fetal-and-neonatal-impact
#6
Wilfrido Coronell-Rodríguez, Cindy Arteta-Acosta, M Alejandra Suárez-Fuentes, M Cecilia Burgos-Rolon, M Teresa Rubio-Sotomayor, Michelle Sarmiento-Gutiérrez, Carlos Corzo-Díaz
Zika virus (ZV) is an arbovirus transmitted by Aedes aegypti and A. albopictus. The neurotropic profile of this virus is known since 1952. The main finding related to ZV in America is microcephaly. Two hypotheses are tested on its involvement in the central nervous system: its neurotropic feature and the direct effect of ZV on the placenta. Malformations and clinical findings on fetal development comprise congenital Zika syndrome. RT-PCR and serology (IgM) are useful for definitive diagnosis. However, we should keep in mind first that the viremia in pregnant women can stay for a longer period of time, and second, a positive IgM for Zika should be properly interpreted in an endemic area to other flavivirus...
December 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27475895/structural-basis-of-zika-virus-specific-antibody-protection
#7
Haiyan Zhao, Estefania Fernandez, Kimberly A Dowd, Scott D Speer, Derek J Platt, Matthew J Gorman, Jennifer Govero, Christopher A Nelson, Theodore C Pierson, Michael S Diamond, Daved H Fremont
Zika virus (ZIKV) infection during pregnancy has emerged as a global public health problem because of its ability to cause severe congenital disease. Here, we developed six mouse monoclonal antibodies (mAbs) against ZIKV including four (ZV-48, ZV-54, ZV-64, and ZV-67) that were ZIKV specific and neutralized infection of African, Asian, and American strains to varying degrees. X-ray crystallographic and competition binding analyses of Fab fragments and scFvs defined three spatially distinct epitopes in DIII of the envelope protein corresponding to the lateral ridge (ZV-54 and ZV-67), C-C' loop (ZV-48 and ZV-64), and ABDE sheet (ZV-2) regions...
August 11, 2016: Cell
https://www.readbyqxmd.com/read/27474488/-zika-virus-infection-a-new-public-health-emergency-with-great-media-impact
#8
Joan A Caylà, Ángela Domínguez, Elena Rodríguez Valín, Fernando de Ory, Ana Vázquez, Claudia Fortuny
Infection with Zika virus (ZV) has become a new epidemic, with great impact on the media, and is having a strong effect in Latin American countries. Its possible association with microcephaly and Guillain-Barré syndrome prompted the World Health Organization (WHO) to declare on 1 February 2016 that this epidemic is a public health emergency of international concern. Epidemiological data show an increasing incidence in countries like Brazil and Colombia, and that the epidemic is still expanding in many other countries...
November 2016: Gaceta Sanitaria
https://www.readbyqxmd.com/read/26593408/magnetic-phase-diagram-of-superantiferromagnetic-tbcu%C3%A2-nanoparticles
#9
C Echevarria-Bonet, D P Rojas, J I Espeso, J Rodríguez Fernández, M de la Fuente Rodríguez, L Fernández Barquín, L Rodríguez Fernández, P Gorria, J A Blanco, M L Fdez-Gubieda, E Bauer, F Damay
The structural state and static and dynamic magnetic properties of TbCu2 nanoparticles are reported to be produced by mechanical milling under inert atmosphere. The randomly dispersed nanoparticles as detected by TEM retain the bulk symmetry with an orthorhombic Imma lattice and Tb and Cu in the 4e and 8h positions, respectively. Rietveld refinements confirm that the milling produces a controlled reduction of particle sizes reaching ≃6 nm and an increase of the microstrain up to ≃0.6%. The electrical resistivity indicates a metallic behavior and the presence of a magnetic contribution to the electronic scattering which decreases with milling times...
December 16, 2015: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/26452397/cellular-and-humoral-responses-to-a-second-dose-of-herpes-zoster-vaccine-administered-10-years-after-the-first-dose-among-older-adults
#10
Myron J Levin, Kenneth E Schmader, Lei Pang, Angela Williams-Diaz, Gary Zerbe, Jennifer Canniff, Michael J Johnson, Yupanqui Caldas, Alice Cho, Nancy Lang, Shu-Chih Su, Janie Parrino, Zoran Popmihajlov, Adriana Weinberg
BACKGROUND: Herpes zoster vaccine (ZV) was administered as a second dose to 200 participants ≥ 70 years old who had received a dose of ZV ≥ 10 years previously (NCT01245751). METHODS: Varicella zoster virus (VZV) antibody titers (measured by a VZV glycoprotein-based enzyme-linked immunosorbent assay [gpELISA]) and levels of interferon γ (IFN-γ) and interleukin 2 (IL-2; markers of VZV-specific cell-mediated immunity [CMI], measured by means of ELISPOT analysis) in individuals aged ≥ 70 years who received a booster dose of ZV were compared to responses of 100 participants aged 50-59 years, 100 aged 60-69 years, and 200 aged ≥ 70 years who received their first dose of ZV...
January 1, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/26269278/new-regression-model-for-predicting-hand-arm-vibration-hav-of-malaysian-army-ma-three-tonne-truck-steering-wheels
#11
Shamsul Akmar Ab Aziz, Mohd Zaki Nuawi, Mohd Jailani Mohd Nor
OBJECTIVE: The objective of this study was to present a new method for determination of hand-arm vibration (HAV) in Malaysian Army (MA) three-tonne truck steering wheels based on changes in vehicle speed using regression model and the statistical analysis method known as Integrated Kurtosis-Based Algorithm for Z-Notch Filter Technique Vibro (I-kaz Vibro). METHODOLOGY: The test was conducted for two different road conditions, tarmac and dirt roads. HAV exposure was measured using a Brüel & Kjær Type 3649 vibration analyzer, which is capable of recording HAV exposures from steering wheels...
2015: Journal of Occupational Health
https://www.readbyqxmd.com/read/26119002/post-embryonic-development-in-the-mite-suborder-opilioacarida-with-notes-on-segmental-homology-in-parasitiformes-arachnida
#12
Hans Klompen, Ma Magdalena Vázquez, Leopoldo Ferreira de Oliveira Bernardi
In order to study homology among the major lineages of the mite (super)order Parasitiformes, developmental patterns in Opilioacarida are documented, emphasizing morphology of the earliest, post-embryonic instars. Developmental patterns are summarized for all external body structures, based on examination of material in four different genera. Development includes an egg, a 6-legged prelarva and larva, three 8-legged nymphal instars, and the adults, for the most complete ontogenetic sequence in Parasitiformes...
October 2015: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/26114827/management-and-prevention-of-herpes-zoster-ocular-disease
#13
REVIEW
Elisabeth J Cohen
Herpes zoster (HZ) is caused by reactivation of latent varicella zoster virus (VZV) in people who have had chicken pox, usually resulting in a painful, unilateral, dermatomal, vesicular rash. Herpes zoster ophthalmicus occurs when the first division of cranial nerve V is involved. HZ is common, with approximately 1 million new cases per year in the United States, and occurs in 1 in 3 persons. Although the rate of HZ increases with age, over half of all cases occur under the age of 60 years. Complications of herpes zoster ophthalmicus include eye disease, postherpetic neuralgia (PHN), and strokes...
October 2015: Cornea
https://www.readbyqxmd.com/read/26024972/effects-of-ovarian-dopaminergic-receptors-on-ovulation
#14
Berenice Venegas-Meneses, José Francisco Padilla, Claudia Elvira Juárez, José Luis Morán, Carolina Morán, Nora Hilda Rosas-Murrieta, Anabella Handal, Roberto Domínguez
Hormonal and neural signals regulate the ovarian follicular development. The present study's hypothesis is that the blockade of ovarian dopamine receptors locally will affect follicle development and ovulation. Groups of adult 4-day cyclic rats of the CII-ZV strain on estrus, diestrus-1, diestrus-2, or proestrus day were injected with vehicle, haloperidol (DA2 > DA1 blocker), sulpiride (DA2 blocker), or SCH-23390 (DA1 blocker) into the bursa of both ovaries at 08:00, 13:00, or 20:00 h. Animals were sacrificed the following predicted estrus day...
December 2015: Endocrine
https://www.readbyqxmd.com/read/25966739/persistent-dilemmas-in-zoster-eye-disease
#15
REVIEW
Elisabeth J Cohen, Jason Kessler
Herpes zoster ophthalmicus (HZO) is a common, vision and potentially life-threatening disease caused by the reactivation of the varicella-zoster virus (VZV) in the distribution of the first division of cranial nerve V. Although the rate of herpes zoster increases with age, over half of the people with zoster in general, including HZO, are under age 60. In addition, over 90% of people with zoster are immunocompetent, even though the disease is more common and severe in immunocompromised patients. The incidence of zoster is increasing worldwide for unknown reasons...
January 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/25964168/safety-tolerability-and-immunogenicity-of-zoster-vaccine-in-subjects-on-chronic-maintenance-corticosteroids
#16
RANDOMIZED CONTROLLED TRIAL
Amy F Russell, Janie Parrino, Chester L Fisher, Wolfgang Spieler, Jon E Stek, Kathleen E Coll, Shu-Chih Su, Jin Xu, Xiaoming Li, Katia Schlienger, Jeffrey L Silber
BACKGROUND: This randomized, placebo-controlled study assessed the safety, tolerability, and immunogenicity of live virus zoster vaccine (ZV) in individuals receiving chronic/maintenance systemic corticosteroid therapy (daily dose equivalent of 5-20mg prednisone) for ≥2 weeks prior to vaccination and ≥6 weeks postvaccination. METHODS: Subjects were followed for adverse experiences (AEs), exposure to varicella or herpes zoster (HZ), or development of varicella/varicella-like or HZ/HZ-like rashes for 42 days postvaccination (primary safety follow-up period) and for serious AEs (SAEs) through Day 182 postvaccination (secondary follow-up period)...
June 17, 2015: Vaccine
https://www.readbyqxmd.com/read/25831086/a-robust-method-to-detect-zero-velocity-for-improved-3d-personal-navigation-using-inertial-sensors
#17
Zhengyi Xu, Jianming Wei, Bo Zhang, Weijun Yang
This paper proposes a robust zero velocity (ZV) detector algorithm to accurately calculate stationary periods in a gait cycle. The proposed algorithm adopts an effective gait cycle segmentation method and introduces a Bayesian network (BN) model based on the measurements of inertial sensors and kinesiology knowledge to infer the ZV period. During the detected ZV period, an Extended Kalman Filter (EKF) is used to estimate the error states and calibrate the position error. The experiments reveal that the removal rate of ZV false detections by the proposed method increases 80% compared with traditional method at high walking speed...
2015: Sensors
https://www.readbyqxmd.com/read/25057492/mannosylated-chitosan-nanoparticles-for-delivery-of-antisense-oligonucleotides-for-macrophage-targeting
#18
Gyati Shilakari Asthana, Abhay Asthana, Dharm Veer Kohli, Suresh Prasad Vyas
The therapeutic potential of antisense oligonucleotides (ASODN) is primarily dependent upon its safe and efficient delivery to specific cells overcoming degradation and maximizing cellular uptake in vivo. The present study focuses on designing mannosylated low molecular weight (LMW) chitosan nanoconstructs for safe ODNs delivery by macrophage targeting. Mannose groups were coupled with LMW chitosan and characterized spectroscopically. Mannosylated chitosan ODN nanoparticles (MCHODN NPs) were formulated by self-assembled method using various N/P ratio (moles of amine groups of MCH to phosphate moieties of ODNs) and characterized for gel retardation assay, physicochemical characteristics, cytotoxicity and transfection efficiency, and antisense assay...
2014: BioMed Research International
https://www.readbyqxmd.com/read/24823623/fold-rise-in-antibody-titers-by-measured-by-glycoprotein-based-enzyme-linked-immunosorbent-assay-is-an-excellent-correlate-of-protection-for-a-herpes-zoster-vaccine-demonstrated-via-the-vaccine-efficacy-curve
#19
RANDOMIZED CONTROLLED TRIAL
Peter B Gilbert, Erin E Gabriel, Xiaopeng Miao, Xiaoming Li, Shu-Chih Su, Janie Parrino, Ivan S F Chan
BACKGROUND: The phase III Zostavax Efficacy and Safety Trial of 1 dose of licensed zoster vaccine (ZV; Zostavax; Merck) in 50-59-year-olds showed approximately 70% vaccine efficacy (VE) to reduce the incidence of herpes zoster (HZ). An objective of the trial was to assess immune response biomarkers measuring antibodies to varicella zoster virus (VZV) by glycoprotein-based enzyme-linked immunosorbent assay as correlates of protection (CoPs) against HZ. METHODS: The principal stratification vaccine efficacy curve framework for statistically evaluating immune response biomarkers as CoPs was applied...
November 15, 2014: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/24762189/hyperoxia-affects-the-regional-pulmonary-ventilation-perfusion-ratio-an-electrical-impedance-tomography-study
#20
Y Li, E Tesselaar, J B Borges, S H Böhm, F Sjöberg, B Janerot-Sjöberg
BACKGROUND: The way in which hyperoxia affects pulmonary ventilation and perfusion is not fully understood. We investigated how an increase in oxygen partial pressure in healthy young volunteers affects pulmonary ventilation and perfusion measured by thoracic electrical impedance tomography (EIT). METHODS: Twelve semi-supine healthy male volunteers aged 21-36 years were studied while breathing room air and air-oxygen mixtures (FiO2) that resulted in predetermined transcutaneous oxygen partial pressures (tcPO2) of 20, 40 and 60 kPa...
July 2014: Acta Anaesthesiologica Scandinavica
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