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https://www.readbyqxmd.com/read/28431202/pharmacological-interventions-for-acute-pancreatitis
#1
REVIEW
Elisabetta Moggia, Rahul Koti, Ajay P Belgaumkar, Federico Fazio, Stephen P Pereira, Brian R Davidson, Kurinchi Selvan Gurusamy
BACKGROUND: In people with acute pancreatitis, it is unclear what the role should be for medical treatment as an addition to supportive care such as fluid and electrolyte balance and organ support in people with organ failure. OBJECTIVES: To assess the effects of different pharmacological interventions in people with acute pancreatitis. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL, 2016, Issue 9), MEDLINE, Embase, Science Citation Index Expanded, and trial registers to October 2016 to identify randomised controlled trials (RCTs)...
April 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28429044/-68-ga-dotatate-pet-ct-in-recurrent-medullary-thyroid-carcinoma-a-lesion-by-lesion-comparison-with-111-in-octreotide-spect-ct-and-conventional-imaging
#2
Lilian Yuri Itaya Yamaga, Marcelo L Cunha, Guilherme C Campos Neto, Marcio R T Garcia, Ji H Yang, Cleber P Camacho, Jairo Wagner, Marcelo B G Funari
PURPOSE: The aim of this study was to prospectively compare the detection rate of (68)Ga-DOTATATE PET-CT with (111)In-octreotide SPECT-CT and conventional imaging (CI) in medullary thyroid carcinoma (MTC) patients with increased calcitonin (Ctn) levels but negative CI after thyroidectomy. METHODS: Fifteen patients with raised Ctn levels and/or CI evidence of recurrence underwent (68)Ga-DOTATATE PET-CT, (111)In-octreotide SPECT-CT and CI. Histopathology, CI and biochemical/clinical/imaging follow-up were used as the reference standard...
April 20, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28403995/comparative-efficacy-of-pharmacological-strategies-for-management-of-type-1-hepatorenal-syndrome-a-systematic-review-and-network-meta-analysis
#3
Antonio Facciorusso, Apoorva K Chandar, M Hassan Murad, Larry J Prokop, Nicola Muscatiello, Patrick S Kamath, Siddharth Singh
BACKGROUND: Several drugs have been studied to improve outcomes for patients with hepatorenal syndrome, but trials have reported variable efficacy. We aimed to compare the efficacy of different management strategies for type 1 hepatorenal syndrome. METHODS: For this systematic review and network meta-analysis, we searched Ovid MEDLINE In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid Embase, Ovid Cochrane Central Register of Controlled Trials, Scopus, and Web of Science for papers published up to June 9, 2016...
February 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28398409/-macrocytosis-of-red-blood-cells-and-early-arthritis-positive-for-rheumatoid-factor-such-as-initial-manifestations-of-a-neuroendocrine-gastrin-secreting-gastric-tumor
#4
Ciro Manzo, Maria Natale, Gennaro Mossetti, Aniello Piscopo
Neuroendocrine tumors (NETs) represent uncommon tumors arising from the excessive proliferation of enterochromaffin-like (ECL) cells (so-called Kulchitsky cell). Gastric NETs (GNET) represent less than 2% of all NETs and less than 1% of all stomach neoplasms. In particular, gastric NETs type 1 (associated to chronic atrophic gastritis and hypergastrinaemia) is the more frequent one, accounting for 70-80% of all GNET. A macrocytic anemia is a frequent manifestation of GNET type 1. The possibility that macrocytic anemia appear during therapy with methotrexate (MTX) is widely documented...
March 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28397723/short-term-preoperative-octreotide-for-thyrotropin-secreting-pituitary-adenoma
#5
Hong-Juan Fang, Yu Fu, Huan-Wen Wu, Yi-Lin Sun, Yang-Fang Li, Ya-Zhuo Zhang, Li-Yong Zhong
BACKGROUND: Thyrotropin-secreting pituitary adenomas (TSHomas) are a rare cause of hyperthyroidism. Somatostatin (SST) analogs work by interacting with somatostatin receptors (SSTRs). This study aimed to evaluate short-term preoperative octreotide (OCT) use in TSHoma patients and to investigate SSTR2 and SSTR5 expression and observe structural changes in tumor tissue. METHODS: We reviewed records and samples from eight TSHoma patients treated between July 2012 and July 2015...
April 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28393010/successful-treatment-of-familial-congenital-chylothorax-by-ligation-of-the-thoracic-duct-a-case-report
#6
Leopoldini Dori, Eleftherios Smaropoulos, Georgios Tagarakis, Christophoros N Foroulis, Paul Zarogoulidis, Haidong Huang, Bai Chong, Wolfgang Hohenforst-Schmidt, George Tsikopoulos
A full term boy was admitted with respiratory distress in the fourth week of his life due to spontaneous chylothorax in his right hemithorax. Spontaneous chylothorax occurred previously in a first cousin of the neonate establishing that way the final diagnosis of familial idiopathic congenital pneumothorax. Failure of the conservative treatment consisting of chest tube drainage, discontinuation of oral diet and administration of total parenteral nutrition in combination with octreotide for one month was followed by the successful ligation of the thoracic duct through a right thoracotomy...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28387769/-99-tc-m-octreotide-scintigraphy-and-serum-eye-muscle-antibodies-in-evaluation-of-active-thyroid-associated-ophthalmopathy
#7
B Sun, Z Zhang, C Dong, Y Zhang, C Yan, S Li
PurposeAs an autoimmune inflammatory disorder, active thyroid-associated ophthalmopathy (TAO) is managed optimally by immunosuppression. In this study, we aimed to evaluate octreotide scintigraphy and the level of serum extraocular muscle antibodies in TAO activity.Patients and methodsThis prospective study comprised 304 patients with active TAO (the clinical activity score; CAS≥3), 73 with inactive TAO (CAS<3), 128 with Graves' disease (GD) without ophthalmopathy, and 100 healthy subjects. Moderate-to-severe active TAO patients (CAS≥5) received intravenous injection of methylprednisolone; mild active patients (3≤CAS≤4) received periocular injection of triamcinolone acetonide...
April 7, 2017: Eye
https://www.readbyqxmd.com/read/28384065/phase-iii-prospective-randomized-comparison-trial-of-depot-octreotide-plus-interferon-alfa-2b-versus-depot-octreotide-plus-bevacizumab-in-patients-with-advanced-carcinoid-tumors-swog-s0518
#8
James C Yao, Katherine A Guthrie, Cesar Moran, Jonathan R Strosberg, Matthew H Kulke, Jennifer A Chan, Noelle LoConte, Robert R McWilliams, Edward M Wolin, Bassam Mattar, Shannon McDonough, Helen Chen, Charles D Blanke, Howard S Hochster
Purpose Treatment options for neuroendocrine tumors (NETs) remain limited. This trial assessed the progression-free survival (PFS) of bevacizumab or interferon alfa-2b (IFN-α-2b) added to octreotide among patients with advanced NETs. Patients and Methods Southwest Oncology Group (SWOG) S0518, a phase III study conducted in a US cooperative group system, enrolled patients with advanced grades 1 and 2 NETs with progressive disease or other poor prognostic features. Patients were randomly assigned to treatment with octreotide LAR 20 mg every 21 days with either bevacizumab 15 mg/kg every 21 days or 5 million units of IFN-α-2b three times per week...
April 6, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28382252/octreotide-as-an-adjunct-in-the-management-of-arterial-gastrointestinal-bleeding-should-it-be-considered-in-refractory-cases-of-obscure-origin
#9
Noel B Martins, Kimberly J Chaput, Stanislaw P Stawicki, Ronak Modi
No abstract text is available yet for this article.
January 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/28379327/evidence-that-endogenous-somatostatin-inhibits-episodic-but-not-surge-secretion-of-lh-in-female-sheep
#10
Richard B McCosh, Brett M Szeligo, Michelle N Bedenbaugh, Justin A Lopez, Steven L Hardy, Stanley M Hileman, Michael N Lehman, Robert L Goodman
Two modes of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion are necessary for female fertility: surge and episodic secretion, however the neural systems that regulate these GnRH secretion patterns are still under investigation. The neuropeptide somatostatin (SST) inhibits episodic luteinizing hormone (LH) secretion in humans and sheep, and several lines of evidence suggest SST may regulate secretion during the LH surge. In this study, we examined whether SST alters the LH surge in ewes by administering a SST receptor 2 (SSTR2) agonist (octreotide) or antagonist (CYN154806; CYN) into the third ventricle during an estrogen-induced LH surge, and whether endogenous SST alters episodic LH secretion...
April 3, 2017: Endocrinology
https://www.readbyqxmd.com/read/28374712/-external-pancreatic-fistulas-management
#11
E V Stepan, A S Ermolov, M L Rogal', Yu S Teterin
The main principles of treatment of external postoperative pancreatic fistulas are viewed in the article. Pancreatic trauma was the reason of pancreatic fistula in 38.7% of the cases, operations because of acute pancreatitis - in 25.8%, and pancreatic pseudocyst drainage - in 35.5%. 93 patients recovered after the treatment. Complex conservative treatment of EPF allowed to close fistulas in 74.2% of the patients with normal patency of the main pancreatic duct (MPD). The usage of octreotide 600-900 mcg daily for at least 5 days to decrease pancreatic secretion was an important part of the conservative treatment...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28372573/treatment-adherence-and-persistence-with-long-acting-somatostatin-analog-therapy-for-the-treatment-of-acromegaly-a-retrospective-analysis
#12
Michelle H Gurel, Yi Han, Andrea L Stevens, Aaron Furtado, David Cox
BACKGROUND: Many patients with acromegaly require medical treatment that includes somatostatin analogs (SSAs). Long-acting SSA formulations are widely used, due in part to increased patient convenience and increased treatment adherence vs daily medications. Although medication compliance can be poor in patients with chronic conditions, adherence and persistence with these SSAs in patients with acromegaly has not been evaluated. This analysis utilized claims data to estimate treatment adherence and persistence for lanreotide depot and long-acting octreotide in this population...
April 4, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28352627/treatment-of-cirrhosis-associated-hyponatremia-with-midodrine-and-octreotide
#13
Sharad Patel, Dai-Scott Nguyen, Anjay Rastogi, Minh-Kevin Nguyen, Minhtri K Nguyen
BACKGROUND: Hyponatremia in the setting of cirrhosis is a common electrolyte disorder with few therapeutic options. The free water retention is due to non-osmotic vasopressin secretion resulting from the cirrhosis-associated splanchnic vasodilatation. Therefore, vasoconstrictive therapy may correct this electrolyte abnormality. The aim of this study was to assess the efficacy of midodrine and octreotide as a therapeutic approach to increasing urinary electrolyte-free water clearance (EFWC) in the correction of cirrhosis-associated hyponatremia...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28349445/prophylactic-use-of-octreotide-for-asparaginase-induced-acute-pancreatitis
#14
Sachi Sakaguchi, Takeshi Higa, Mitsuyoshi Suzuki, Junya Fujimura, Toshiaki Shimizu
In the present study, we sought to evaluate the prophylactic use of octreotide for asparaginase-induced acute pancreatitis. We reviewed the medical records of seven patients in two institutions who received prophylactic octreotide for re-administration of asparaginase after asparaginase-induced acute pancreatitis. Three patients completed asparaginase treatment without developing pancreatitis, and four experienced recurrence of pancreatitis. A literature search using PubMed identified four additional patients in whom asparaginase was successfully re-administered with octreotide...
March 27, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28349291/preliminary-pet-ct-imaging-with-somatostatin-analogs-68-ga-dotaga-tate-and-68-ga-dotaga-toc
#15
Drishty Satpati, Ajit Shinto, K K Kamaleshwaran, Haladhar Dev Sarma, Ashutosh Dash
PURPOSE: Somatostatin receptor positron emission tomography/X-ray computed tomography (SSTR-PET/CT) is a well-established technique for staging and detection of neuroendocrine tumors (NETs). Ga-68-labeled DOTA-conjugated octreotide analogs are the privileged radiotracers for diagnosis and therapeutic monitoring of NETs. Hence, we were interested in assessing the influence of promising, newer variant DOTAGA on the hydrophilicity, pharmacokinetics, and lesion pick-up of somatostatin analogs...
March 27, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28342580/evidence-based-management-of-chylothorax-in-infants
#16
Joseph T Church, Alexis G Antunez, Ashley Dean, Niki Matusko, Kristopher B Deatrick, Mohammad A Attar, Samir K Gadepalli
PURPOSE: Management guidelines for infants with chylothorax lack substantial evidence. We sought to identify variables that impact outcomes in these patients in order to develop an evidence-based management algorithm. METHODS: We retrospectively reviewed the medical records of all infants diagnosed with chylothorax from June 2005 to December 2014 at our institution. Data collected included demographics, chest tube output (CTO), medical and dietary interventions, surgical procedures, and absolute lymphocyte count (ALC)...
March 16, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28342443/incidental-metastatic-mediastinal-atypical-carcinoid-in-a-patient-with-parathyroid-adenoma-a-case-report
#17
Zareen Kiran, Asma Ahmed, Owais Rashid, Saira Fatima, Faizan Malik, Saulat Fatimi, Mubassher Ikram
BACKGROUND: Atypical carcinoid arising from the mediastinal tissue is a rare neuroendocrine tumor and an association with parathyroid adenoma is very unusual. We report an unusual case of atypical carcinoid of mediastinum with metastasis in a patient presenting with parathyroid adenoma, which is the first case to be reported from Pakistan. CASE PRESENTATION: A 51-year-old Pakistani man was seen in postoperative intensive care after right parathyroidectomy and mediastinal mass resection for the management of postoperative hypocalcaemia...
March 26, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28342098/expression-of-cell-cycle-regulators-and-biomarkers-of-proliferation-and-regrowth-in-human-pituitary-adenomas
#18
Mark Gruppetta, Robert Formosa, Sharon Falzon, Sabrina Ariff Scicluna, Edward Falzon, James Degeatano, Josanne Vassallo
PURPOSE: The pathogenesis of pituitary adenomas (PA) is complex. Ki-67, pituitary tumour transforming gene (PTTG), vascular endothelial growth factor (VEGF), cyclin D1, c-MYC and pituitary adenylate cyclase-activating peptide (PACAP) protein expression were analysed and correlated with tumour and patient characteristics. METHODS: 74 pituitary tumour samples (48 non-functional PA, 26 functional PAs); Immunohistochemical analysis of protein expression, retrospective analysis of MR images and in vitro analysis of octreotide treatment was carried out on GH3 cells...
March 24, 2017: Pituitary
https://www.readbyqxmd.com/read/28341976/development-and-evaluation-of-user-friendly-single-vial-dota-peptide-kit-formulations-specifically-designed-for-radiolabelling-with-68-ga-from-a-tin-dioxide-68-ge-68-ga-generator
#19
Deidré Prince, Daniel Rossouw, Claudia Davids, Sietske Rubow
PURPOSE: This study was aimed to develop single vial 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-peptide kits to be used with fractionated eluates from a SnO2-based (68)Ge/(68)Ga generator. PROCEDURES: Kits were formulated with 35 μg DOTA-Tyr(3)-Thre(8)-octreotide, DOTA-[Tyr(3)]-octreotide and DOTA-[NaI(3)]-octreotide (DOTATATE, DOTATOC and DOTANOC) and sodium acetate powder, vacuum-dried and stored at -20 °C for up to 12 months. Labelling of the kits was carried out with 2 ml (68)Ga eluate...
March 24, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28340493/conservative-treatment-with-octreotide-to-provide-early-recovery-of-children-with-esophageal-perforation
#20
Ramazan Karabulut, Zafer Turkyilmaz, Kaan Sonmez, Abdullah Can Basaklar
Background The effectiveness of nonoperative treatment of esophageal perforation (EP) in children with octreotide is highlighted. Methods Records of nine patients (seven boys and two girls with an average age of 5.83 ± 5.35 years) with EP were reviewed. Results EP developed in six patients during dilation of esophageal stenosis (five of six caused by caustic burns). In the other three patients, EP developed after nasogastric placement, after endotracheal intubation, and during endoscopy for foreign body...
March 24, 2017: Thoracic and Cardiovascular Surgeon
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