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https://www.readbyqxmd.com/read/29141860/multicenter-evaluation-of-octreotide-as-secondary-prophylaxis-in-patients-with-left-ventricular-assist-devices-and-gastrointestinal-bleeding
#1
Keyur B Shah, Sampath Gunda, Sitaramesh Emani, Manreet K Kanwar, Nir Uriel, Paolo C Colombo, Patricia A Uber, Melissa L Sears, Joyce Chuang, David J Farrar, Donald F Brophy, George B Smallfield
BACKGROUND: Gastrointestinal (GI) bleeding is one of the most common complications after continuous-flow left ventricular assist device implantation. More than one third of patients with incident bleed go on to develop recurrent GI bleeding. Octreotide, a somatostatin analog, is proposed to reduce the risk of recurrent GI bleeding in this population. METHODS AND RESULTS: This multicenter, retrospective analysis evaluated 51 continuous-flow left ventricular assist device patients who received secondary prophylaxis with octreotide after their index GI bleed from 2009 to 2015...
November 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29127751/-the-benefit-of-new-angiogenesis-bevacizumab-and-aflibercept-inhibitors-for-multiple-angiomatosis-therapy-a%C3%A2-case-report
#2
Dagmar Brančíková, Lenka Ostřížková, Zdeněk Adam, Tomáš Nebeský, Luděk Pour, Zdeněk Král, Jiří Mayer
Angiomatosis is a term for multiple, gradually proliferating hemangiomas (angiodysplasia), affecting multiple organs or tissues at the same time. We describe a 12-year course of treatment of a patient with multiple hemangiomas located in the abdomen, retroperitoneum, oesophagus, mediastinum and also in vertebrae. The diagnosis was made in 2005 within probatory laparotomy, at the age of 28 years. The treatment was commenced right after making the diagnosis with interferon α. Due to its adverse effects (fatigue, anorexia), the use of interferon α was limited to the first year, after which the interferon dose was gradually being reduced until it was discontinued completely...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29122616/practice-patterns-of-medications-for-patients-with-malignant-bowel-obstruction-using-a-nationwide-claims-database-and-the-association-between-treatment-outcomes-and-concomitant-use-of-h2-blockers-proton-pump-inhibitors-and-corticosteroids-with-octreotide
#3
Takaaki Minoura, Masato Takeuchi, Tatsuya Morita, Koji Kawakami
CONTEXT: Malignant bowel obstruction (MBO) impairs the quality of life in patients with advanced cancer. Octreotide, acid-suppressing medications such as H<sub>(2)</sub>-receptor antagonists (H<sub>(2)</sub> blockers) and proton pump inhibitors (PPIs), and corticosteroids are often used in combination for symptom control. OBJECTIVES: We evaluated the practice patterns of medications for patients hospitalized with MBO using a large claims database in Japan...
November 6, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29118868/efficacy-of-video-capsule-endoscopy-in-the-management-of-suspected-small-bowel-bleeding-in-patients-with-continuous-flow-left-ventricular-assist-devices
#4
Thomas A Zikos, Jennifer Pan, Berkeley Limketkai, Dipanjan Banerjee, Nielsen Fernandez-Becker
Background: Continuous flow left ventricular assist device (CF-LVAD) patients have a high prevalence of gastrointestinal bleeding from the small bowel. Video capsule endoscopy (VCE) is often used for diagnosis in these patients, but efficacy has yet to be determined. In this study, we evaluated the efficacy of VCE in the management of CF-LVAD patients with suspected small bowel bleeding by comparing to a non-VCE CF-LVAD control group. Methods: We retrospectively reviewed the charts of all patients with CF-LVADs implanted at Stanford Hospital from January 2010 to October 2015...
October 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29116540/long-term-safety-of-long-acting-octreotide-in-patients-with-diabetic-retinopathy-results-of-pooled-data-from-2-randomized-double-blind-placebo-controlled-phase-3-studies
#5
Rosario Pivonello, Giovanna Muscogiuri, Geoffrey Holder, Michaela Paul, Severine Sarp, Anastasia Lesogor, Pierre Jordaan, Johannes Eisinger, Annamaria Colao
PURPOSE: Octreotide (OCT) has been successfully used for treatment of acromegaly and neuroendocrine tumors for more than 30 years. However, long-term safety of OCT has not been documented in placebo-controlled setting. This present analysis pooled safety data from two similarly-designed, randomized, and placebo-controlled studies to evaluate long-term safety of long-acting OCT (20, 30 mg); targeted post-hoc analyzes focused on cardiac, hepatic, and renal safety. METHODS: Two studies (NCT00131144, NCT001308450) were conducted in patients with diabetic retinopathy (OCT20 = 191, OCT30 = 348, placebo = 347)...
November 7, 2017: Endocrine
https://www.readbyqxmd.com/read/29116340/18f-dopa-pet-ct-and-68ga-dotanoc-pet-ct-scans-as-diagnostic-tools-in-focal-congenital-hyperinsulinism-a-blinded-evaluation
#6
Charlotte Dahl Christiansen, Henrik Petersen, Anne Lerberg Nielsen, Sönke Detlefsen, Klaus Brusgaard, Lars Rasmussen, Maria Melikyan, Klas Ekström, Evgenia Globa, Annett Helleskov Rasmussen, Claus Hovendal, Henrik Thybo Christesen
PURPOSE: Focal congenital hyperinsulinism (CHI) is curable by surgery, which is why identification of the focal lesion is crucial. We aimed to determine the use of 18F-fluoro-dihydroxyphenylalanine (18F-DOPA) PET/CT vs. 68Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic-acid-1-Nal3-octreotide (68Ga-DOTANOC) PET/CT as diagnostic tools in focal CHI. METHODS: PET/CT scans of children with CHI admitted to Odense University Hospital between August 2005 and June 2016 were retrospectively evaluated visually and by their maximal standardized uptake values (SUVmax) by two independent examiners, blinded for clinical, surgical and pathological data...
November 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29111999/terlipressin-is-superior-to-midodrine-octreotide-for-hepatorenal-syndrome-type-1
#7
Georgios N Kalambokis, Gerasimos Baltayiannis, Dimitrios Christodoulou, Leonidas Christou
No abstract text is available yet for this article.
December 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29108520/a-proposed-classification-system-and-therapeutic-strategy-for-chyle-leak-after-laparoscopic-living-donor-nephrectomy-a-single-center-experience-and-review-of-the-literature
#8
Zi Qin Ng, Bulang He
OBJECTIVES: Chyle leak or chylous ascites remains a rare complication after laparoscopic living-donor nephrectomy. Its cause and management have not been well elucidated in the literature. Thus, the aim of this study was to review the incidence of chyle leak/chylous ascites after laparoscopic living-donor nephrectomy in our institute and in the literature to propose a classification system with its associated treatment strategy. MATERILAS AND METHODS: In this retrospective review of laparoscopic living-donor nephrectomy patients from January 2005 to April 2016, we identified patients with chyle leak/chylous ascites along with the care performed...
October 31, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29093373/-function-of-perivascular-nerves-in-insulin-resistance-induced-hypertension
#9
Shingo Takatori
 Many patients with type 2 diabetes mellitus develop hypertension, although the actual mechanism remains unknown. To clarify possible mechanisms of hypertension development in diabetes, this study investigated the acute or chronic influence of hyperinsulinemia and/or hyperglycemia on the function of perivascular nerves, which play a critical role in vascular tone regulation. Acute hyperinsulinemia in euglycemic pithed rats, which had no autonomic flow, significantly augmented adrenergic nerve-mediated pressor responses and inhibited calcitonin gene-related peptide (CGRP)-containing (CGRPergic) nerve-mediated depressor responses...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29092972/tranexamic-acid-in-treatment-resistant-chronic-transfusion-dependent-gastrointestinal-angiodysplasia-bleeding
#10
Karina V Grooteman, Erwin J M van Geenen, Joost P H Drenth
A small proportion of gastrointestinal angiodysplasia bleeding leads to chronic blood cell transfusion dependency. There are no guidelines supporting decision-making among various treatments in patients with gastrointestinal angiodysplasia bleeding. When endoscopic argon plasma coagulation is ineffective, the angiogenesis inhibitors thalidomide and octreotide can be considered. We describe a 77-year-old woman who had side effects of these angiogenesis inhibitors, which caused her to have continued bleeding...
November 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29080355/tumour-lateralization-in-cushing-s-disease-by-inferior-petrosal-sinus-sampling-with-desmopressin
#11
Ming Feng, Ziyuan Liu, Xiaohai Liu, Xiaobo Zhang, Xinjie Bao, Yong Yao, Kan Deng, Bing Xing, Wei Lian, Huijuan Zhu, Lin Lu, Renzhi Wang
BACKGROUND: Bilateral inferior petrosal sinus sampling (IPSS) with corticotropin-releasing hormone (CRH) is currently the gold standard in the diagnosis of Cushing's disease (CD) and has also been used in tumour lateralization. Our objective was to determine the diagnostic value and lateralization accuracy of IPSS with desmopressin. METHODS: We retrospectively analyzed 91 patients with Cushing's syndrome who had either negative findings on pituitary dynamic enhanced magnetic resonance imaging (MRI) or non-suppressed high dose dexamethasone suppression tests (HDDST)...
October 28, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29066893/application-of-multifunctional-targeting-epirubicin-liposomes-in-the-treatment-of-non-small-cell-lung-cancer
#12
Xiao-Li Song, Rui-Jun Ju, Yao Xiao, Xin Wang, Shuang Liu, Min Fu, Jing-Jing Liu, Li-Yan Gu, Xue-Tao Li, Lan Cheng
Chemotherapy for aggressive non-small-cell lung cancer (NSCLC) usually results in a poor prognosis due to tumor metastasis, vasculogenic mimicry (VM) channels, limited killing of tumor cells, and severe systemic toxicity. Herein, we developed a kind of multifunctional targeting epirubicin liposomes to enhance antitumor efficacy for NSCLC. In the liposomes, octreotide was modified on liposomal surface for obtaining a receptor-mediated targeting effect, and honokiol was incorporated into the lipid bilayer for inhibiting tumor metastasis and eliminating VM channels...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29058089/evidence-based-treatment-of-neurogenic-orthostatic-hypotension-and-related-symptoms
#13
REVIEW
Sabine Eschlböck, Gregor Wenning, Alessandra Fanciulli
Neurogenic orthostatic hypotension, postprandial hypotension and exercise-induced hypotension are common features of cardiovascular autonomic failure. Despite the serious impact on patient's quality of life, evidence-based guidelines for non-pharmacological and pharmacological management are lacking at present. Here, we provide a systematic review of the literature on therapeutic options for neurogenic orthostatic hypotension and related symptoms with evidence-based recommendations according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE)...
October 22, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29038234/patient-reported-symptom-control-of-diarrhea-and-flushing-in-patients-with-neuroendocrine-tumors-treated-with-lanreotide-depot-autogel-results-from-a-randomized-placebo-controlled-double-blind-and-32-week-open-label-study
#14
George A Fisher, Edward M Wolin, Nilani Liyanage, Susan Pitman Lowenthal, Beloo Mirakhur, Rodney F Pommier, Montaser Shaheen, Aaron Vinik
BACKGROUND: In the double-blind (DB) ELECT study, lanreotide depot/autogel significantly reduced versus placebo the need for short-acting octreotide for symptomatic carcinoid syndrome (CS) control in neuroendocrine tumor (NET) patients. Here we present patient-reported symptom data during DB and initial open-label (IOL) treatment. MATERIALS AND METHODS: Adults with NETs and CS history, with/without prior somatostatin analog use, were randomized to 16 weeks' DB lanreotide 120 mg subcutaneous or placebo every 4 weeks, followed by 32 weeks' IOL lanreotide...
October 16, 2017: Oncologist
https://www.readbyqxmd.com/read/29030760/patient-specific-dosimetry-of-99m-tc-hynic-tyr-3-octreotide-in-children
#15
Xinchi Hou, Bozena Birkenfeld, Hanna Piwowarska-Bilska, Anna Celler
BACKGROUND: Technetium-99m-hydrazinonicotinamide-Tyr(3)-octreotide ((99m)Tc-HYNIC-TOC) is recognized as a promising radiopharmaceutical for diagnosing neuroendocrine tumors (NETs). However, (99m)Tc-HYNIC-TOC dosimetry has been investigated only for adults. As pediatric radionuclide therapies become increasingly common, similar dosimetric studies for children are urgently needed. The aim of this study is to report personalized image-based biodistributions and dosimetry evaluations for children studies performed using (99m)Tc-HYNIC-TOC and to compare them with those from adult subjects...
October 13, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/29026555/pasireotide-and-octreotide-in-the-treatment-of-severe-late-dumping-syndrome
#16
Alireza Mohammadi, Raashda A Sulaiman, Ashley B Grossman
Hypoglycemia due to late dumping is a significant problem postoesophagectomy but may not always be diagnosed sufficiently early. It can be difficult to treat and may severely compromise quality of life. The combination of diazoxide and octreotide or more probably pasireotide may transform the patient's life and should be considered in all problematic cases.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29021448/additional-octreotide-therapy-to-sirolimus-achieved-a-decrease-in-sirolimus-refractory-chylous-effusion-complicated-with-lymphangioleiomyomatosis
#17
Masashi Namba, Takeshi Masuda, Takashi Nakamura, Yasushi Horimasu, Shintaro Miyamoto, Taku Nakashima, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Recently, sirolimus, an inhibitor of mammalian target of rapamycin, was reported to decrease chylous effusion in patients with lymphangioleimyomatosis (LAM). We herein report a case of a 34-year-old woman with LAM who developed refractory chylothorax and chylous ascites during sirolimus therapy. In this case, to reduce chylous effusion, we administered octreotide, which is often used to control postoperative chylous effusion, in addition to the sirolimus therapy. This combination therapy reduced the chylothorax and chylous ascites...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28991106/pharmacological-therapies-for-hepatorenal-syndrome-a-systematic-review-and-meta-analysis
#18
Arjun Nanda, Rewanth Reddy, Humaira Safraz, Salameh Habeeb, Ashwani K Singal
BACKGROUND: Hepatorenal syndrome (HRS) is a serious complication of advanced chronic liver disease. Different pharmacological therapies have variable efficacy. We performed a systematic review and meta-analysis to compare the efficacy of various drugs in the treatment of HRS. STUDY: Randomized controlled trials comparing active drug with placebo or comparing 2 different drugs were included in this analysis. Primary study outcome was reversal of HRS. Secondary outcomes were HRS relapse and patient survival...
October 4, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28984754/late-presentation-of-necrotizing-enterocolitis-associated-with-rotavirus-infection-in-a-term-infant-with-hyperinsulinism-on-octreotide-therapy-a-case-report
#19
Abdulaziz A Alsaedi, Ayman A Bakkar, Naglaa M Kamal, Jwaher M Althobiti
RATIONALE: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy that can cause permanent brain damage. Consequently, optimal management is extremely important. Current pharmacologic and surgical treatment were available that included diazoxide and octreotides. PATIENT CONCERNS: A 4 month old Saudi male patient diagnosed at our hospital as CHI, treated with near total pancreatectomy and octreotide therapy of 30 mcg/kg/day presented with severe abdominal distension, vomiting and bloody diarrhea...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28984677/advances-in-the-understanding-and-management-of-mucositis-during-stem-cell-transplantation
#20
Joanne M Bowen, Hannah R Wardill
PURPOSE OF REVIEW: Mucositis is a severe and common side effect of anticancer treatments, with an incidence of between 40 and 80% depending on the cytotoxic regimen used. The most profound mucositis burden is experienced during conditioning regimens for hematopoietic stem cell transplant (HSCT), where the use of highly mucotoxic agents with or without total body irradiation leads to serious damage throughout the alimentary tract. Currently, the assessment and management of both oral and gastrointestinal mucositis lack authoritative guideline, with recommendations only achieved in narrow clinical scenarios...
December 2017: Current Opinion in Supportive and Palliative Care
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