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https://www.readbyqxmd.com/read/27936365/how-much-is-too-much-patterns-of-drinking-during-alcohol-treatment-and-associations-with-post-treatment-outcomes-across-three-alcohol-clinical-trials
#1
Katie Witkiewitz, Corey R Roos, Matthew R Pearson, Kevin A Hallgren, Stephen A Maisto, Megan Kirouac, Alyssa A Forcehimes, Adam D Wilson, Charles S Robinson, Elizabeth McCallion, J Scott Tonigan, Nick Heather
OBJECTIVE: This secondary data analysis examined patterns of drinking during alcohol treatment and associated drinking outcomes during the first year following treatment. The goal was to provide clinicians with guidance on which patients may be most at risk for negative long-term outcomes based on drinking patterns during treatment. METHOD: This study was an analysis of existing data (N = 3,851) from three randomized clinical trials for alcohol use disorder: the COMBINE Study (n = 1,383), Project MATCH (n = 1,726), and the United Kingdom Alcohol Treatment Trial (n = 742)...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27935626/assessment-of-radial-torsion-using-computed-tomography-in-dogs-with-and-without-antebrachial-limb-deformity
#2
Kevin Kroner, Katie Cooley, Seamus Hoey, Scott J Hetzel, Jason A Bleedorn
OBJECTIVE: To evaluate the reliability of radial torsion assessment in dogs using computed tomography (CT). STUDY DESIGN: Cadaveric and retrospective observational clinical study. ANIMALS: Thoracic limbs (n = 40) from bilateral normal cadaveric canine specimens (10 pairs) and unilateral antebrachial angular limb deformity (ALD) dogs (10 uniapical and 10 biapical deformities). METHODS: Limbs were evaluated using CT...
December 9, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27935085/muscle-activation-during-resistance-exercise-at-70-and-90-1rm-in-resistance-trained-men
#3
Adam M Gonzalez, Jamie J Ghigiarelli, Katie M Sell, Edward W Shone, Christopher F Kelly, Gerald T Mangine
INTRODUCTION: Muscle activation during resistance exercise with 2 relatively high-intensity loads was investigated. METHODS: Ten resistance-trained men performed the leg press exercise to repetition failure: a set at 70% of 1-repetition maximum (1RM) and a set at 90% of 1RM. Surface electromyography (EMG) was used to assess peak and mean muscle activation of the vastus lateralis, rectus femoris, and vastus medialis. RESULTS: Peak and mean EMG remained greater at 90% than 70% 1RM across all repetitions (P=0...
December 9, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27934966/the-mechanism-of-a-formaldehyde-sensing-transcriptional-regulator
#4
Katie J Denby, Jeffrey Iwig, Claudine Bisson, Jodie Westwood, Matthew D Rolfe, Svetlana E Sedelnikova, Khadine Higgins, Michael J Maroney, Patrick J Baker, Peter T Chivers, Jeffrey Green
Most organisms are exposed to the genotoxic chemical formaldehyde, either from endogenous or environmental sources. Therefore, biology has evolved systems to perceive and detoxify formaldehyde. The frmRA(B) operon that is present in many bacteria represents one such system. The FrmR protein is a transcriptional repressor that is specifically inactivated in the presence of formaldehyde, permitting expression of the formaldehyde detoxification machinery (FrmA and FrmB, when the latter is present). The X-ray structure of the formaldehyde-treated Escherichia coli FrmR (EcFrmR) protein reveals the formation of methylene bridges that link adjacent Pro2 and Cys35 residues in the EcFrmR tetramer...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27933647/whole-woman-s-health-v-hellerstedt-and-the-current-implications-for-abortion-access
#5
Y Tony Yang, Katy B Kozhimannil
No abstract text is available yet for this article.
December 9, 2016: Birth
https://www.readbyqxmd.com/read/27933019/reduced-working-memory-mediates-the-link-between-early-institutional-rearing-and-symptoms-of-adhd-at-12-years
#6
Florin Tibu, Margaret A Sheridan, Katie A McLaughlin, Charles A Nelson, Nathan A Fox, Charles H Zeanah
Children who are raised in institutions show severe delays across multiple domains of development and high levels of psychopathology, including attention deficit/hyperactivity disorder (ADHD). Low performance in executive functions (EFs) are also common in institutionally reared children and often do not remediate following improvements in the caregiving environment. ADHD symptomatology also remains elevated even after children are removed from institutional care and placed in families. We investigate whether poor EF is a mechanism explaining elevated rates of ADHD in children reared in institutional settings in the Bucharest Early Intervention Project (BEIP)...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27932348/toggling-the-egfr-signaling-pathway
#7
Katie Gerhardt
No abstract text is available yet for this article.
December 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27931123/developments-in-multibreath-washout-testing-in-children-with-cystic-fibrosis
#8
Clare Saunders, Katie Bayfield, Samantha Irving, Christopher Short, Andrew Bush, Jane C Davies
Lung Clearance Index (LCI) is becoming recognized as an important addition in the monitoring of pediatric cystic fibrosis (CF). The non-invasive technique is easy to perform in all ages, reproducible and increasingly being used in clinical trials. There is interest to utilize it within the clinic setting but its current use is mostly as a research tool. The procedure is highly dependent on skilled operators and a relaxed testing environment is key to obtaining good quality measurements. Standardization of LCI is part of an ongoing collaborative, multicenter process...
December 9, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27930454/fat-free-mass-index-in-ncaa-division-i-and-ii-collegiate-american-football-players
#9
Eric T Trexler, Abbie E Smith-Ryan, Malia N M Blue, Richard M Schumacher, Jerry L Mayhew, J Bryan Mann, Pat A Ivey, Katie R Hirsch, Meredith G Mock
Fat-free mass index (FFMI) is a height-adjusted assessment of fat-free mass, with previous research suggesting a natural upper limit of 25 kg[BULLET OPERATOR]m in resistance-trained males. The current study evaluated upper limits for FFMI in collegiate American football players (n=235), and evaluated differences between positions, divisions, and age groups. The sample consisted of two NCAA Division I teams (n=78, n=69), and one Division II team (n=88). Body composition was assessed via dual-energy x-ray absorptiometry and used to calculate FFMI; linear regression was used to normalize values to a height of 180 cm...
November 19, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27929198/b%C3%AE-arg448lys-polymorphism-is-associated-with-altered-fibrin-clot-structure-and-fibrinolysis-in-type-2-diabetes
#10
Katie A Greenhalgh, Mark W Strachan, Saad Alzahrani, Paul D Baxter, Kristina F Standeven, Robert F Storey, Robert A S Ariens, Peter J Grant, Jackie F Price, Ramzi A Ajjan
Both type 2 diabetes (T2DM) and Bβ448Lys variant of fibrinogen are associated with dense fibrin clots, impaired fibrinolysis and increased cardiovascular risk. It was our objective to investigate whether BβArg448Lys adds to vascular risk by modulating fibrin network structure and/or fibrinolysis in diabetes. The primary aim was to study effects of BβArg448Lys on fibrin network characteristics in T2DM. Secondary aims investigated interactions between gender and BβArg448Lys substitution in relation to fibrin clot properties and vascular disease...
December 8, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27928002/adjuvanting-an-siv-vaccine-with-tlr-ligands-encapsulated-in-nanoparticles-induces-persistent-antibody-responses-and-enhanced-protection-in-trim5%C3%AE-restrictive-macaques
#11
Sudhir Pai Kasturi, Pamela A Kozlowski, Helder I Nakaya, Matheus C Burger, Pedro Russo, Mathew Pham, Yevgeniy Kovalenkov, Eduardo L V Silveira, Colin Havenar-Daughton, Samantha L Burton, Katie M Kilgore, Mathew J Johnson, Rafiq Nabi, Traci Legere, Zarpheen Jinnah Sher, Xuemin Chen, Rama R Amara, Eric Hunter, Steven E Bosinger, Paul Spearman, Shane Crotty, Francois Villinger, Cynthia A Derdeyn, Jens Wrammert, Bali Pulendran
: Our previous work has shown that antigens adjuvanted with specific ligands for toll-like receptor 4 (TLR4) and TLR7/8 encapsulated in poly (lactic-co-glycolic acid) (PLGA) based nanoparticles (NP), induced robust and durable immune responses in mice and macaques. We investigated the efficacy of these NP adjuvants in inducing protective immunity against simian immunodeficiency virus (SIV). Rhesus macaques (RMs) were immunized with NP containing TLR4 and TLR7/8 agonists mixed with soluble recombinant SIVmac239 derived envelope (Env) gp140 and Gag p55 (Protein), or with virus like particles (VLP) containing SIVmac239 Env and Gag...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27927647/gvhd-prevents-nk-cell-dependent-leukemia-and-virus-specific-innate-immunity
#12
Mark D Bunting, Antiopi Varelias, Fernando Souza-Fonseca-Guimaraes, Iona S Schuster, Katie E Lineburg, Rachel D Kuns, Peter Fleming, Kelly R Locke, Nicholas D Huntington, Bruce R Blazar, Steven W Lane, Siok-Keen Tey, Kelli P A MacDonald, Mark J Smyth, Mariapia A Degli-Esposti, Geoffrey R Hill
Allogeneic bone marrow transplantation (allo-BMT) is a curative therapy for hematological malignancies, but is associated with significant complications, principally graft-versus-host disease (GVHD) and opportunistic infections. Natural killer (NK) cells mediate important innate immunity that provides a temporal bridge until the reconstruction of adaptive immunity. Here we show that the development of GVHD after allo-BMT prevented NK-cell reconstitution, particularly within the maturing M1 and M2 NK-cell subsets in association with exaggerated activation, apoptosis and autophagy...
December 7, 2016: Blood
https://www.readbyqxmd.com/read/27927122/respite-services-for-children-with-life-limiting-conditions-and-their-families-in-ireland
#13
Katie Hill
Appropriate respite care for children with life-limiting conditions (LLC) and their families is the cornerstone of high quality paediatric care. The effect of caring for children with LLC on families, including parental needs, cannot be underestimated and respite can give families support while caring for their children. There are many different types of respite care available in Ireland, including specialist respite, inhome respite or out-of-home respite; the wishes of the family should be sought when arranging care...
December 8, 2016: Nursing Children and Young People
https://www.readbyqxmd.com/read/27927014/genetic-modification-of-the-lung-directed-toward-treatment-of-human-disease
#14
Dolan Sondhi, Katie Stiles, Bishnu P De, Ronald G Crystal
Genetic modification therapy is a promising therapeutic strategy for many diseases of the lung intractable to other treatments. Lung gene therapy has been the subject of numerous preclinical animal experiments and human clinical trials, for targets including genetic diseases such as cystic fibrosis and α1-antitrypsin deficiency, complex disorders such as asthma, allergy and lung cancer, infections such as respiratory syncytial virus and Pseudomonas, as well as pulmonary arterial hypertension, transplant rejection and lung injury...
December 7, 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27926863/chronic-infection-depletes-hematopoietic-stem-cells-through-stress-induced-terminal-differentiation
#15
Katie A Matatall, Mira Jeong, Siyi Chen, Deqiang Sun, Fengju Chen, Qianxing Mo, Marek Kimmel, Katherine Y King
Chronic infections affect a third of the world's population and can cause bone marrow suppression, a severe condition that increases mortality from infection. To uncover the basis for infection-associated bone marrow suppression, we conducted repeated infection of WT mice with Mycobacterium avium. After 4-6 months, mice became pancytopenic. Their hematopoietic stem and progenitor cells (HSPCs) were severely depleted and displayed interferon gamma (IFN-γ) signaling-dependent defects in self-renewal. There was no evidence of increased HSPC mobilization or apoptosis...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27925268/therapists-assessments-in-treating-sex-addiction-and-their-relationship-to-clients-gender-relationship-status-and-exclusivity-status
#16
Geoffrey T Reddick, Katie M Heiden-Rootes, Andrew S Brimhall
A total of 208 therapists and therapists-in-training were surveyed to better understand if clinical assessments and recommendations regarding "sex addiction" changed based upon a client's gender, relationship status, or exclusivity status. Using clinical vignettes, this study examined the clinical assessment and recommendations of licensed mental health providers (n = 92) and mental health providers in-training (n = 116). Results indicated that professional ratings differed based on relationship exclusivity and gender; specifically, female nonmonogamous behavior was rated more negatively than male nonmonogamous behavior, while male monogamous behavior was rated more negatively than female monogamous behavior...
December 7, 2016: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/27925165/pugs-a-novel-scale-to-assess-perceptions-of-uncertainties-in-genome-sequencing
#17
Barbara B Biesecker, Samuel W Woolford, William Mp Klein, Kyle B Brothers, Kendall L Umstead, Katie L Lewis, Leslie G Biesecker, Paul Kj Han
Expectations of results from genome sequencing by end users are influenced by perceptions of uncertainty. This study aimed to assess uncertainties about sequencing by developing, evaluating, and implementing a novel scale. The Perceptions of Uncertainties in Genome Sequencing (PUGS) scale comprised ten items to assess uncertainties within three domains: clinical, affective, and evaluative. Participants (n=535) from the ClinSeq® NIH sequencing study completed a baseline survey that included the PUGS; responses (mean = 3...
December 7, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27924904/coping-skills
#18
Katie Peek
No abstract text is available yet for this article.
August 16, 2016: Scientific American
https://www.readbyqxmd.com/read/27924879/urban-wealth
#19
Katie Peek
No abstract text is available yet for this article.
August 16, 2016: Scientific American
https://www.readbyqxmd.com/read/27924634/the-promise-of-circulating-tumor-cells-for-precision-cancer-therapy
#20
William L Hwang, Katie L Hwang, David T Miyamoto
The rapidly growing array of therapeutic options in cancer requires informative biomarkers to guide the rational selection and precision application of appropriate therapies. Circulating biomarkers such as circulating tumor cells have immense potential as noninvasive, serial 'liquid biopsies' that may be more representative of the complete spectrum of a patient's individual malignancy than spatially and temporally restricted tumor biopsies. In this review, we discuss the current state-of-the-art in the isolation and molecular characterization of circulating tumor cells as well as their utility in a wide range of clinical applications such as prognostics, treatment monitoring and identification of novel therapeutic targets and resistance mechanisms to enable real-time adjustments in the clinical management of cancer...
December 7, 2016: Biomarkers in Medicine
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