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https://www.readbyqxmd.com/read/28922416/multi-level-computational-methods-for-interdisciplinary-research-in-the-hathitrust-digital-library
#1
Jaimie Murdock, Colin Allen, Katy Börner, Robert Light, Simon McAlister, Andrew Ravenscroft, Robert Rose, Doori Rose, Jun Otsuka, David Bourget, John Lawrence, Chris Reed
We show how faceted search using a combination of traditional classification systems and mixed-membership topic models can go beyond keyword search to inform resource discovery, hypothesis formulation, and argument extraction for interdisciplinary research. Our test domain is the history and philosophy of scientific work on animal mind and cognition. The methods can be generalized to other research areas and ultimately support a system for semi-automatic identification of argument structures. We provide a case study for the application of the methods to the problem of identifying and extracting arguments about anthropomorphism during a critical period in the development of comparative psychology...
2017: PloS One
https://www.readbyqxmd.com/read/28922038/a-mixed-methods-study-of-emotional-exhaustion-energizing-and-depleting-work-within-an-innovative-healthcare-team
#2
Cindy L Cain, Caitlin Taborda-Whitt, Monica Frazer, Sandra Schellinger, Katie M White, Jason Kaasovic, Brenda Nelson, Allison Chant
This mixed methods study documents emotional exhaustion experiences among care team members during the development of an innovative team approach for caring for adults with serious illness. A mixed methods study design was employed to examine depleting work experiences that may produce emotional exhaustion, and energizing aspects of the work that may increase meaningfulness of work, thus reducing emotional exhaustion. The population studied included team members involved in care for adults with serious illness (n = 18)...
September 18, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28921997/simulating-drinking-in-social-networks-to-inform-alcohol-prevention-and-treatment-efforts
#3
Kevin A Hallgren, Barbara S McCrady, Thomas P Caudell, Katie Witkiewitz, J Scott Tonigan
Adolescent drinking influences, and is influenced by, peer alcohol use. Several efficacious adolescent alcohol interventions include elements aimed at reducing susceptibility to peer influence. Modeling these interventions within dynamically changing social networks may improve our understanding of how such interventions work and for whom they work best. We used stochastic actor-based models to simulate longitudinal drinking and friendship formation within social networks using parameters obtained from a meta-analysis of real-world 10th grade adolescent social networks...
September 18, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28921667/polysubstance-use-among-adolescents-in-a-low-income-rural-community-latent-classes-for-middle-and-high-school-students
#4
Roderick A Rose, Caroline B R Evans, Paul R Smokowski, Matthew O Howard, Katie L Stalker
PURPOSE: Rural communities are currently being impacted by a nationwide epidemic of prescription opioid misuse. Rural adolescent substance users may be at substantial risk for later addiction to these and other drugs. METHODS: This study uses Latent Class Analysis to identify subtypes of polysubstance users among a sample of 7,074 rural adolescents. Separate models were estimated for middle- and high-school youth. Predictive validity was estimated using cumulative ordinal logistic regression of the classes on a set of youth and family characteristics...
September 18, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28921576/rape-myth-acceptance-in-sexually-assaulted-adolescents-school-contexts-associations-with-depressed-mood-and-alcohol-use
#5
Emily R Dworkin, Stephanie N Sessarego, Samantha L Pittenger, Katie M Edwards, Victoria L Banyard
High school students exposed to sexual assault (SA) are at risk for negative outcomes like depressed mood and high-risk drinking. Although evidence suggests that both social contexts and internalized stigma can affect recovery from SA, no research to date has directly examined the presence of stigma in social contexts such as high schools as a correlate of adjustment after SA. In this study, the self-reported rape myth acceptance (RMA) of 3080 students from 97 grade cohorts in 25 high schools was used to calculate grade-mean and school-mean RMA, which was entered into multilevel models predicting depressed mood and alcohol use among N = 263 SA survivors within those schools...
September 18, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28920951/srebp-controlled-glucose-metabolism-is-essential-for-nk-cell-functional-responses
#6
Nadine Assmann, Katie L O'Brien, Raymond P Donnelly, Lydia Dyck, Vanessa Zaiatz-Bittencourt, Róisín M Loftus, Paul Heinrich, Peter J Oefner, Lydia Lynch, Clair M Gardiner, Katja Dettmer, David K Finlay
Activated natural killer (NK) cells engage in a robust metabolic response that is required for normal effector function. Using genetic, pharmacological and metabolic analyses, we demonstrated an essential role for Srebp transcription factors in cytokine-induced metabolic reprogramming of NK cells that was independent of their conventional role in the control of lipid synthesis. Srebp was required for elevated glycolysis and oxidative phosphorylation and promoted a distinct metabolic pathway configuration in which glucose was metabolized to cytosolic citrate via the citrate-malate shuttle...
September 18, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28920761/can-ultra-wide-field-retinal-imaging-replace-colour-digital-stereoscopy-for-glaucoma-detection
#7
Nicola B Quinn, Augusto Azuara-Blanco, Katie Graham, Ruth E Hogg, Ian S Young, Frank Kee
PURPOSE: Ultra-wide field (UWF) retinal imaging (Optomap, Optos plc, Dunfermline, UK) is a novel technique to image the peripheral fundus. The goal of this study was to explore the potential use of UWF imaging to detect glaucoma, and specifically to evaluate the reproducibility of measures of vertical cup-to-disc ratio (VCDR) using ultra-wide field (UWF), and the agreement between UWF and standard colour digital stereoscopy (CDS). METHODS: An observational study...
September 18, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28919391/the-added-value-of-the-90-day-repeated-dose-oral-toxicity-test-for-industrial-chemicals-with-a-low-sub-acute-toxicity-profile-in-a-high-quality-dataset-an-update
#8
Katy Taylor, David J Andrew
A previous retrospective analysis of substances in the ECHA CHEM database concluded that, for industrial chemicals with a 'low (sub)acute toxicity profile', further testing in the 90-day study is unlikely to change this profile (Taylor et al., 2014). We have further tested this hypothesis by assessing the outcome of substances with testing proposals for which a prediction was made in that paper that the NOAEL based on the 90-day study would be 1000 mg/kg bw/d. Indeed, for seven out of ten substances for which data was available, the profile was shown to be held...
September 15, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28919080/regulation-of-glutamate-transporter-1-glt-1-gene-expression-by-cocaine-self-administration-and-withdrawal
#9
Ronald Kim, Marian T Sepulveda-Orengo, Kati L Healey, Emily A Williams, Kathryn J Reissner
Downregulation of the astroglial glutamate transporter GLT-1 is observed in the nucleus accumbens (NAc) following administration of multiple drugs of abuse. The decrease in GLT-1 protein expression following cocaine self-administration is dependent on both the amount of cocaine self-administered and the length of withdrawal, with longer access to cocaine and longer withdrawal periods leading to greater decreases in GLT-1 protein. However, the mechanism(s) by which cocaine downregulates GLT-1 protein remains unknown...
September 14, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28918710/trametinib-for-the-treatment-of-ighv4-34-map2k1-mutant-variant-hairy-cell-leukemia
#10
Leslie A Andritsos, Nicole R Grieselhuber, Mirela Anghelina, Kerry A Rogers, Sameek Roychowdhury, Julie W Reeser, Cynthia D Timmers, Aharon G Freud, James S Blachly, David M Lucas, Gerard Lozanski, Jeffrey A Jones, Katie Williams, Christopher Oakes, Dan Jones, Michael R Grever
No abstract text is available yet for this article.
September 18, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28918105/factors-influencing-women-s-decision-making-in-hysterectomy
#11
Monika Janda, Nigel R Armfield, Katie Page, Gayle Kerr, Suzanne Kurz, Graeme Jackson, Jason Currie, Edward Weaver, Anusch Yazdani, Andreas Obermair
OBJECTIVE: To explore factors influencing how well-informed women felt about hysterectomy, influences on their decision making, and on them receiving a less-invasive alternative to open surgery. METHODS: Online questionnaire, conducted in 2015-2016, of women who had received a hysterectomy in Australia, in the preceding two years. RESULTS: Questionnaires were completed by 2319/6000 women (39% response). Most women (n=2225; 96%) felt well-informed about hysterectomy...
September 12, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28917491/strengths-and-challenges-of-the-alaska-wic-breastfeeding-peer-counselor-program-a%C3%A2-qualitative-study-of-program-implementation
#12
Katie Cueva, Sarah Shimer, Dana Kent, Alan C Geller, K Viswanath, Teresa T Fung
OBJECTIVE: To explore the implementation of a breastfeeding (BF) peer counselor (BFPC) program with Alaska Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). METHODS: The study used focus groups, surveys, and interviews, with transcripts analyzed in Atlas.ti and survey data summarized in Microsoft Excel. RESULTS: Respondents included 33 interviewed WIC staff and BFPCs, 25 clients in focus groups, and 129 surveyed clients...
September 13, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28916658/t-cells-deficient-in-diacylglycerol-kinase-%C3%AE-are-resistant-to-pd-1-inhibition-and-help-create-persistent-host-immunity-to-leukemia
#13
Weiqing Jing, Jill Alane Gershan, Sandra Holzhauer, James Weber, Katie Palen, Laura McOlash, Kirthi Pulakanti, Erin Wesley, Sridhar Rao, Bryon D Johnson, Matthew J Riese
Efforts to improve the efficacy of adoptive T cell therapies and immune checkpoint therapies in myelogenous leukemia are desired. In this study, we evaluated the anti-leukemia activity of adoptively transferred polyclonal cancer antigen-reactive T cells deficient in the regulator diacylglycerol kinase-zeta (DGKζ) with or without PD-1/PD-L1 blockade. In the C1498 mouse model of myeloid leukemia, we showed that leukemia was eradicated more effectively in DGKζ-deficient (DGKζ-/-) mice than wild-type mice. T cells transferred from DGKζ-deficient mice to wild-type tumor-bearing recipients conferred this benefit...
September 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28916434/effects-of-icos-t-cell-depletion-via-afucosylated-monoclonal-antibody-medi-570-on-pregnant-cynomolgus-monkeys-and-the-developing-offspring
#14
Simone M Nicholson, Gianluca Carlesso, Lily I Cheng, Halie Cook, Karma DaCosta, Joel Leininger, Kathleen McKeever, Stephen Weasel Scott, Devon Taylor, Katie Streicher, Steve Eck, Molly Reed, Raffaella Faggioni, Ronald Herbst, Rakesh Dixit, Patricia C Ryan
MEDI-570 is a fully human afucosylated monoclonal antibody (MAb) against Inducible T-cell costimulator (ICOS), highly expressed on CD4+ T follicular helper (TFH) cells. Effects of MEDI-570 were evaluated in an enhanced pre-postnatal development toxicity (ePPND) study in cynomolgus monkeys. Administration to pregnant monkeys did cause any abortifacient effects. Changes in hematology and peripheral blood T lymphocyte subsets in maternal animals and infants and the attenuated infant IgG immune response to keyhole limpet hemocyanin (KLH) were attributed to MEDI-570 pharmacology...
September 12, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28915919/project-lifeskills-a-randomized-controlled-efficacy-trial-of-a-culturally-tailored-empowerment-based-and-group-delivered-hiv-prevention-intervention-for-young-transgender-women-study-protocol
#15
Lisa M Kuhns, Matthew J Mimiaga, Sari L Reisner, Katie Biello, Robert Garofalo
BACKGROUND: Transgender women in the U.S. have an alarmingly high incidence rate of HIV infection; condomless anal and vaginal sex is the primary risk behavior driving transmission. Young transgender women are the subpopulation at the highest risk for HIV. Despite this, there are no published randomized controlled efficacy trials testing interventions to reduce sexual risk for HIV among this group. This paper describes the design of a group-based intervention trial to reduce sexual risk for HIV acquisition and transmission in young transgender women...
September 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28914959/nocturia-is-associated-with-poor-sleep-quality-among-older-women-in-the-study-of-osteoporotic-fractures
#16
Constance H Fung, Camille P Vaughan, Alayne D Markland, Alison J Huang, Michael N Mitchell, Donald L Bliwise, Sonia Ancoli-Israel, Susan Redline, Cathy A Alessi, Katie Stone
OBJECTIVES: (1) To examine relationships between frequency of nocturia and self-reported sleep quality and objective sleep measures in older women, and (2) to estimate the amount of variation in sleep measures that is specifically attributable to frequency of nocturia. DESIGN AND SETTING: Secondary, cross sectional analysis of the multicenter prospective cohort Study of Osteoporotic Fractures (SOF). PARTICIPANTS: Community-dwelling women aged ≥80 years...
September 15, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28914701/elevated-postvoid-residual-urine-volume-identifying-risk-factors-and-predicting-resolution-in-women-with-pelvic-organ-prolapse
#17
Amanda Ulrich, Patricia Davis, Paul Tulikangas, David M OʼSullivan, Katie Propst
OBJECTIVES: This study aims to identify risk factors for elevated preoperative postvoid residual (PVR) and persistently elevated postoperative PVR and to evaluate the resolution rate of elevated PVR urine volume in patients undergoing reconstructive surgery for pelvic organ prolapse (POP). METHODS: This was a retrospective cohort study comparing 50 women with elevated preoperative PVR (≥100 mL) and 50 women with normal PVR (<100 mL). Preoperative demographic, physical examination, urodynamic data, type of surgery performed, and postoperative trial of void data were collected...
September 13, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28913947/extreme-chromosome-17-copy-number-instability-is-a-prognostic-factor-in-patients-with-gastroesophageal-adenocarcinoma-a-retrospective-cohort-study
#18
Jacqueline E Birkness, Neal G Spada, Caitlyn Miller, James D Luketich, Katie S Nason, Weijing Sun, Jon M Davison
Gastric and esophageal cancers frequently show genomic instability and aneuploidy. Chromosomal copy number instability (CIN) is a form of genomic instability that exerts pleiotropic effects on cellular biology and is a source of genetic heterogeneity in a population of cells. CIN results in cell-to-cell variation in chromosome copy number which can be detected and quantified by fluorescence in situ hybridization (FISH). CIN is a biomarker associated with differential response to a number of chemotherapy compounds...
September 14, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28912964/is-the-south-african-triage-scale-valid-for-use-in-afghanistan-haiti-and-sierra-leone
#19
Mohammed Dalwai, Pola Valles, Michele Twomey, Yvonne Nzomukunda, Prince Jonjo, Manoj Sasikumar, Masood Nasim, Abdul Razaaq, Olivia Gayraud, Pierre Ronald Jecrois, Lee Wallis, Katie Tayler-Smith
OBJECTIVE: To assess the validity of the South African Triage Scale (SATS) in four Médecins Sans Frontières (MSF)-supported emergency departments (ED, two trauma-only sites, one mixed site (both medical and trauma cases) and one paediatric-only site) in Afghanistan, Haiti and Sierra Leone. METHODS: This was a retrospective cohort study conducted between June 2013 and June 2014. Validity was assessed by comparing patients' SATS ratings with their final ED outcome (ie, hospital admission, death or discharge)...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/28911946/suboptimal-interobserver-agreement-among-cytopathologists-for-endoscopic-ultrasound-fine-needle-aspirates-of-solid-pancreatic-lesions
#20
Carrie Marshall, Rawad Mounzer, Matt Hall, Violette Simon, Barbara Centeno, Katie Dennis, Jasreman Dhillon, Fang Fan, Laila Khazai, Jason Klapman, Srinadh Komanduri, Xiaoqi Lin, David Lu, Sanjana Mehrotra, V Raman Muthusamy, Ritu Nayar, Ajit Paintal, Jianyu Rao, Sharon Sams, Janak Shah, Rabindra Watson, Amit Rastogi, Sachin Wani
BACKGROUND AND AIMS: Despite the widespread use of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and the standardization of pancreaticobiliary cytopathologic nomenclature, data on interobserver agreement (IOA) amongst cytopathologists evaluating pancreatic tissue specimens are limited. We aimed to assess IOA among cytopathologists evaluating EUS-FNA specimens of solid pancreatic lesions for overall cytologic diagnosis and quantitative and qualitative parameters using a novel standardized scoring tool and to evaluate predictors of agreement...
September 11, 2017: Clinical Gastroenterology and Hepatology
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