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JOURNAL ARTICLE
Hesna Kara, Alexander Axer, Frederick W Muskett, Carlos J Bueno-Alejo, Vasileios Paschalis, Andrea Taladriz-Sender, Sumera Tubasum, Marina Santana Vega, Zhengyun Zhao, Alasdair W Clark, Andrew J Hudson, Ian C Eperon, Glenn A Burley, Cyril Dominguez
Protein-RNA interactions are central to numerous cellular processes. In this work, we present an easy and straightforward NMR-based approach to determine the RNA binding site of RNA binding proteins and to evaluate the binding of pairs of proteins to a single-stranded RNA (ssRNA) under physiological conditions, in this case in nuclear extracts. By incorporation of a 19 F atom on the ribose of different nucleotides along the ssRNA sequence, we show that, upon addition of an RNA binding protein, the intensity of the 19 F NMR signal changes when the 19 F atom is located near the protein binding site...
2024: Frontiers in Molecular Biosciences
#22
JOURNAL ARTICLE
María de la Sierra Espinar-Buitrago, Esmeralda Magro-López, Elena Vázquez-Alejo, María Ángeles Muñoz-Fernández
Resistance and toxicity associated with current treatments for human cytomegalovirus (HCMV) infection highlight the need for alternatives and immunotherapy has emerged as a promising strategy. This study examined the in vitro immunological effects of co-administration of Thymosin-alpha-1 (Tα1) and polyanionic carbosilane dendrimers (PCDs) on peripheral blood mononuclear cells (PBMCs) during HCMV infection. The biocompatibility of PCDs was assessed via MTT and LDH assays. PBMCs were pre-treated with the co-administered compounds and then exposed to HCMV for 48 h...
February 6, 2024: International Journal of Molecular Sciences
#23
JOURNAL ARTICLE
Daniel Alpízar-Pedraza, Yessica Roque-Diaz, Hilda Garay-Pérez, Frank Rosenau, Ludger Ständker, Vivian Montero-Alejo
CIDEM-501 is a hybrid antimicrobial peptide rationally designed based on the structure of panusin and panulirin template peptides. The new peptide exhibits significant antibacterial activity against multidrug-resistant pathogens (MIC = 2-4 μM) while conserving no toxicity in human cell lines. We conducted molecular dynamics (MD) simulations using the CHARMM-36 force field to explore the CIDEM-501 adsorption mechanism with different membrane compositions. Several parameters that characterize these interactions were analyzed to elucidate individual residues' structural and thermodynamic contributions...
February 8, 2024: Antibiotics
#24
JOURNAL ARTICLE
Max F K Wills, Carlos Bueno Alejo, Nikolas Hundt, Andrew J Hudson, Ian C Eperon
The identification of photobleaching steps in single molecule fluorescence imaging is a well-established procedure for analysing the stoichiometries of molecular complexes. Nonetheless, the method is challenging with protein fluorophores because of the high levels of noise, rapid bleaching and highly variable signal intensities, all of which complicate methods based on statistical analyses of intensities to identify bleaching steps. It has recently been shown that deep learning by convolutional neural networks can yield an accurate analysis with a relatively short computational time...
December 2024: Computational and Structural Biotechnology Journal
#25
JOURNAL ARTICLE
Debbie Robbrecht, Jean-Jacques Grob, Oliver Bechter, Matteo Simonelli, Bernard Doger, Ivan Borbath, Marcus O Butler, Tina Cheng, Patricia Martin Romano, Elvire Pons-Tostivint, Massimo Di Nicola, Giuseppe Curigliano, Min-Hee Ryu, Alejo Rodriguez-Vida, Dirk Schadendorf, Elena Garralda, Giovanni Abbadessa, Brigitte Demers, Amele Amrate, Hong Wang, Joon Sang Lee, Robert Pomponio, Rui Wang
SAR439459, a 'second-generation' human anti-transforming growth factor-beta (TGFβ) monoclonal antibody, inhibits all TGFβ isoforms and improves the antitumor activity of anti-programmed cell death protein-1 therapeutics. This study reports the pharmacodynamics (PD) and biomarker results from phase I/Ib first-in-human study of SAR439459 ± cemiplimab in patients with advanced solid tumors (NCT03192345). In dose-escalation phase (Part 1), SAR439459 was administered intravenously at increasing doses either every 2 weeks (Q2W) or every 3 weeks (Q3W) with cemiplimab IV at 3 mg/kg Q2W or 350 mg Q3W, respectively, in patients with advanced solid tumors...
February 2024: Clinical and Translational Science
#26
JOURNAL ARTICLE
Irman Forghani, Steven H Lang, Matthew J Rodier, Stephanie A Bivona, Alejo A Morales, Stephan Zuchner, Guney Bademci, Mustafa Tekin
Phenotypic features of a hereditary connective tissue disorder, including craniofacial characteristics, hyperextensible skin, joint laxity, kyphoscoliosis, arachnodactyly, inguinal hernia, and diverticulosis associated with biallelic pathogenic variants in EFEMP1 have been previously described in four patients. Genome sequencing on a proband and her mother with comparable phenotypic features revealed that both patients were heterozygous for a stop-gain variant c.1084C>T (p.Arg362*). Complementary RNA-seq on fibroblasts revealed significantly reduced levels of mutant EFEMP1 transcript...
February 13, 2024: American Journal of Medical Genetics. Part A
#27
Laura M Winchester, Danielle Newby, Upamanyu Ghose, Peifeng Hu, Hunter Green, Sandy Chien, Janice Ranson, Jessica Faul, David Llewellyn, Jinkook Lee, Sarah Bauermeister, Alejo Nevado-Holgado
BACKGROUND: In India, anemia is widely researched in children and women of reproductive age, however, studies in older populations are lacking. Given the adverse effect of anemia on cognitive function and dementia this older population group warrants further study. The Longitudinal Ageing Study in India - Harmonized Diagnostic Assessment of Dementia (LASI-DAD) dataset contains detailed measures to allow a better understanding of anaemia as a potential risk factor for dementia. METHOD: 2,758 respondents from the LASI-DAD cohort, aged 60 or older, had a complete blood count measured from venous blood as well as cognitive function tests including episodic memory, executive function and verbal fluency...
January 23, 2024: medRxiv
#28
JOURNAL ARTICLE
Pedro L Valenzuela, Alfredo Santalla, Lidia B Alejo, Asunción Bustos, Laureano M Ozcoidi, Laura Castellote-Bellés, Roser Ferrer-Costa, Mónica Villarreal-Salazar, María Morán, David Barranco-Gil, Tomàs Pinós, Alejandro Lucia
BACKGROUND & AIMS: Ketone supplementation is gaining popularity. Yet, its effects on exercise performance when muscle glycogen cannot be used remain to be determined. McArdle disease can provide insight into this question, as these patients are unable to obtain energy from muscle glycogen, presenting a severely impaired physical capacity. We therefore aimed to assess the effects of acute ketone supplementation in the absence of muscle glycogen utilization (McArdle disease). METHODS: In a randomized cross-over design, patients with an inherited block in muscle glycogen breakdown (i...
March 2024: Clinical Nutrition
#29
JOURNAL ARTICLE
Katia Bravo-Jaimes, Tania Vasquez-Loarte, Jose Rojas-Camayo, Monica Medina, Christian R Mejia, Henry Zapata-Galarza, Marilia Berrocal, Jeanette Orozco, Daniel Lozano, Maryuri Santivañez, Carlos Sangay, William Rosales, Leddy Mamani, Nelly Macedo, Joel Coronado, Gian Huaman, Rafael Marquez, Zhuo Li, Kiran M Masood, Juan Alejos, Leigh Reardon, Jeannette Lin
BACKGROUND: Neonatal pulse oximetry screening (POS) algorithms for critical congenital heart disease (CCHD) have contributed towards decreasing neonatal mortality but cannot be applied at high altitudes. New POS algorithms at high altitudes are needed. METHODS: This observational, prospective study included newborns born at different altitudes from 0 to 4380 meters above the sea level in Peru. Healthy newborns underwent neonatal preductal and postductal oximetry, echocardiography and telephonic follow-up up to 12 months of age...
February 2, 2024: Journal of Perinatology: Official Journal of the California Perinatal Association
#30
JOURNAL ARTICLE
Alberto Hernández-Barranco, Vanesa Santos, Marina S Mazariegos, Eduardo Caleiras, Laura Nogués, Frédéric Mourcin, Simon Léonard, Christelle Oblet, Steve Genebrier, Delphine Rossille, Alberto Benguría, Alba Sanz, Enrique Vázquez, Ana Dopazo, Alejo Efeyan, Ana Ortega-Molina, Michel Cogne, Karin Tarte, Héctor Peinado
Nerve growth factor receptor (NGFR) is expressed by follicular dendritic cells (FDCs). However, the role of NGFR in the humoral response is not well defined. Here, we study the effect of Ngfr loss on lymph node organization and function, demonstrating that Ngfr depletion leads to spontaneous germinal center (GC) formation and an expansion of the GC B cell compartment. In accordance with this effect, stromal cells are altered in Ngfr-/- mice with a higher frequency of FDCs, characterized by CD21/35, MAdCAM-1, and VCAM-1 overexpression...
January 30, 2024: Cell Reports
#31
Alejo Efeyan, Matilde Murga, Barbara Martinez-Pastor, Ana Ortega-Molina, Rebeca Soria, Manuel Collado, Oscar Fernandez-Capetillo, Manuel Serrano
[This corrects the article DOI: 10.1371/journal.pone.0005475.].
2024: PloS One
#32
JOURNAL ARTICLE
Vladimir Camarena, Monique M Williams, Alejo A Morales, Mohammad F Zafeer, Okan V Kilic, Ali Kamiar, Clemer Abad, Monica A Rasmussen, Laurence M Briski, LéShon Peart, Guney Bademci, Deborah S Barbouth, Sarah Smithson, Gaofeng Wang, Lina A Shehadeh, Katherina Walz, Mustafa Tekin
Geleophysic Dysplasia-1 (GD1) is an autosomal recessive disorder caused by ADAMTSL2 variants. It is characterized by distinctive facial features, limited joint mobility, short stature with brachydactyly, and the potential for life-threatening cardiovascular and respiratory complications. The clinical spectrum spans from perinatal lethality to milder phenotypes in adult survivors, manifesting a clinical heterogeneity. The Adamtsl2-/- mouse model dies perinatally and hinders further functional investigation. In this study, we developed and characterized cellular and mouse models, which were designed to replicate the genetic profile of a patient who is compound heterozygous for two ADAMTSL2 variants, namely p...
February 1, 2024: JCI Insight
#33
JOURNAL ARTICLE
Hicham Klaina, Imanol Picallo, Peio Lopez-Iturri, Aitor Biurrun, Ana V Alejos, Leyre Azpilicueta, Abián B Socorro-Leránoz, Francisco Falcone
Nowadays, the Industry 4.0 concept and the Industrial Internet of Things (IIoT) are considered essential for the implementation of automated manufacturing processes across various industrial settings. In this regard, wireless sensor networks (WSN) are crucial due to their inherent mobility, easy deployment and maintenance, scalability, and low power consumption, among other benefits. In this context, the presented paper proposes an optimized and low-cost WSN based on ZigBee communication technology for the monitoring of a real manufacturing facility...
January 22, 2024: Sensors
#34
JOURNAL ARTICLE
Alessia Guerrieri, Isabel Cantera, Silvio Marta, Aurélie Bonin, Alexis Carteron, Roberto Ambrosini, Marco Caccianiga, Fabien Anthelme, Roberto Sergio Azzoni, Peter Almond, Pablo Alviz Gazitúa, Sophie Cauvy-Fraunié, Jorge Luis Ceballos Lievano, Pritam Chand, Milap Chand Sharma, John Clague, Justiniano Alejo Cochachín Rapre, Chiara Compostella, Rolando Cruz Encarnación, Olivier Dangles, Philip Deline, Andre Eger, Sergey Erokhin, Andrea Franzetti, Ludovic Gielly, Fabrizio Gili, Mauro Gobbi, Sigmund Hågvar, Norine Khedim, Rosa Isela Meneses, Gwendolyn Peyre, Francesca Pittino, Angela Proietto, Antoine Rabatel, Nurai Urseitova, Yan Yang, Vitalii Zaginaev, Andrea Zerboni, Anaïs Zimmer, Pierre Taberlet, Guglielmina Adele Diolaiuti, Jerome Poulenard, Diego Fontaneto, Wilfried Thuiller, Gentile Francesco Ficetola
The worldwide retreat of glaciers is causing a faster than ever increase in ice-free areas that are leading to the emergence of new ecosystems. Understanding the dynamics of these environments is critical to predicting the consequences of climate change on mountains and at high latitudes. Climatic differences between regions of the world could modulate the emergence of biodiversity and functionality after glacier retreat, yet global tests of this hypothesis are lacking. Nematodes are the most abundant soil animals, with keystone roles in ecosystem functioning, but the lack of global-scale studies limits our understanding of how the taxonomic and functional diversity of nematodes changes during the colonization of proglacial landscapes...
January 2024: Global Change Biology
#35
JOURNAL ARTICLE
Juan Torre-Castro, Marta Rodríguez, Ruth Alonso-Alonso, María Dolores Mendoza Cembranos, Jesús Frutos Díaz-Alejo, Marcos Rebollo-González, Jennifer Borregón, Laura Nájera Botello, Ignacio Mahillo-Fernández, Mathab Samimi, Thibault Kervarrec, Luis Requena, Miguel Ángel Piris
BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive malignant neuroendocrine tumour. There are two subsets of MCC, one related to Merkel cell polyomavirus (MCPyV) and the other to ultraviolet (UV) radiation. MCPyV-positive and MCPyV-negative MCCs have been considered to be different tumours, since the former type harbours few DNA mutations and is not related to UV radiation, and the latter usually arises in sun-exposed areas and may be found in conjunction with other keratinocytic tumours, mostly squamous cell carcinomas...
January 23, 2024: British Journal of Dermatology
#36
JOURNAL ARTICLE
Jean-Francois Darrigrand, Anna Salowka, Alejo Torres-Cano, Rafael Tapia-Rojo, Tong Zhu, Sergi Garcia-Manyes, Francesca M Spagnoli
During organ formation, progenitor cells need to acquire different cell identities and organize themselves into distinct structural units. How these processes are coordinated and how tissue architecture(s) is preserved despite the dramatic cell rearrangements occurring in developing organs remain unclear. Here, we identified cellular rearrangements between acinar and ductal progenitors as a mechanism to drive branching morphogenesis in the pancreas while preserving the integrity of the acinar-ductal functional unit...
January 13, 2024: Developmental Cell
#37
JOURNAL ARTICLE
Isabel Cantera, Alexis Carteron, Alessia Guerrieri, Silvio Marta, Aurélie Bonin, Roberto Ambrosini, Fabien Anthelme, Roberto Sergio Azzoni, Peter Almond, Pablo Alviz Gazitúa, Sophie Cauvy-Fraunié, Jorge Luis Ceballos Lievano, Pritam Chand, Milap Chand Sharma, John Clague, Justiniano Alejo Cochachín Rapre, Chiara Compostella, Rolando Cruz Encarnación, Olivier Dangles, Andre Eger, Sergey Erokhin, Andrea Franzetti, Ludovic Gielly, Fabrizio Gili, Mauro Gobbi, Sigmund Hågvar, Norine Khedim, Rosa Isela Meneses, Gwendolyn Peyre, Francesca Pittino, Antoine Rabatel, Nurai Urseitova, Yan Yang, Vitalii Zaginaev, Andrea Zerboni, Anaïs Zimmer, Pierre Taberlet, Guglielmina Adele Diolaiuti, Jerome Poulenard, Wilfried Thuiller, Marco Caccianiga, Gentile Francesco Ficetola
The mechanisms underlying plant succession remain highly debated. Due to the local scope of most studies, we lack a global quantification of the relative importance of species addition 'versus' replacement. We assessed the role of these processes in the variation (β-diversity) of plant communities colonizing the forelands of 46 retreating glaciers worldwide, using both environmental DNA and traditional surveys. Our findings indicate that addition and replacement concur in determining community changes in deglaciated sites, but their relative importance varied over time...
January 17, 2024: Nature Plants
#38
JOURNAL ARTICLE
Alejo Corrales, Marcelo Cetkovich-Bakmas, Andrea Abadi, Sebastián Camino, Gerardo García Bonetto, Andrea Márquez Lopez Mato, Eliana Marengo, Estela Abraham, Tomás Maresca, Pablo Bagnati, Amalia Dallamea, Diego Canseco, Carlos Morra, Ricardo Corral, Daniel Sotelo, Sergio Strejilevich, Julián Pessio, Juan José Vilapriño, Manuel Vilapriño, Federico Rebok, Gustavo Vázquez
Artículo de revisión El litio es un metal alcalino, usado hace más de 60 años en psiquiatría, y actualmente es considerado el estándar de oro en el tratamiento del trastorno bipolar (TB). De acuerdo con la evidencia reciente, este principio activo es útil para el tratamiento de un amplio espectro de variedades clínicas de los trastornos afectivos. Además, se estima que desde hace tiempo el litio reduce el riesgo de suicidio y de comportamiento suicida en personas con trastornos del estado de ánimo...
January 10, 2024: Vertex: Revista Argentina de Psiquiatriá
#39
JOURNAL ARTICLE
Ivan Montes-Gonzalez, Maximino Avendaño-Alejo, Neil C Bruce, Angel Lizana, Juan Campos
We present an optimal configuration for Stokes polarimeters based on liquid crystal variable retarders, with the minimum number of measurements. Due to the inherent variations of the director orientation of the liquid crystal molecules, we propose a configuration that minimizes the sensibility of the polarimeter to fast-axis variations. For the optimization we consider a scheme that maximizes the volume of a tetrahedron inscribed in the Poincare sphere, to address additive and Poisson noise, with one of the vertices invariant to changes in the axis positions...
January 15, 2024: Optics Letters
#40
JOURNAL ARTICLE
Megan Kurz, Brenda Carolina Guerra-Alejos, Jeong Eun Min, Brittany Barker, Bernadette Pauly, Karen Urbanoski, Bohdan Nosyk
BACKGROUND: Characterizing the diffusion of adopted changes in policy and clinical practice can inform enhanced implementation strategies to ensure prompt uptake in public health emergencies and other rapidly evolving disease areas. A novel guidance document was introduced at the onset of the COVID-19 pandemic in British Columbia (BC), Canada, which supported clinicians to prescribe opioids, stimulants, and benzodiazepines. We aimed to determine the extent to which uptake and discontinuation of an initial attempt at a prescribed safer supply (PSS) program were influenced through networks of prescribers...
January 6, 2024: Implementation Science: IS
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