keyword
MENU ▼
Read by QxMD icon Read
search

alejo

keyword
https://www.readbyqxmd.com/read/28322010/cholesterol-can-modulate-mitochondrial-aquaporin-8-expression-in-human-hepatic-cells
#1
Mauro Danielli, Alejo M Capiglioni, Julieta Marrone, Giuseppe Calamita, Raúl A Marinelli
Hepatocyte mitochondrial aquaporin-8 (mtAQP8) works as a multifunctional membrane channel protein that facilitates the uptake of ammonia for its detoxification to urea as well as the mitochondrial release of hydrogen peroxide. Since early oligonucleotide microarray studies in liver of cholesterol-fed mice showed an AQP8 downregulation, we tested whether alterations of cholesterol content per se modulate mtAQP8 expression in human hepatocyte-derived Huh-7 cells. Cholesterol loading with methyl-β-cyclodextrin (mβCD):cholesterol complexes downregulated the proteolytic activation of cholesterol-responsive sterol regulatory element-binding protein (SREBP) transcriptions factors 1 and 2, and the expression of the target gene 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)...
March 20, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28319048/amino-acid-insensitive-mtorc1-regulation-enables-nutritional-stress-resilience-in-hematopoietic-stem-cells
#2
Demetrios Kalaitzidis, Dongjun Lee, Alejo Efeyan, Youmna Kfoury, Naema Nayyar, David B Sykes, Francois E Mercier, Ani Papazian, Ninib Baryawno, Gabriel D Victora, Donna Neuberg, David M Sabatini, David T Scadden
The mTOR pathway is a critical determinant of cell persistence and growth wherein mTOR complex 1 (mTORC1) mediates a balance between growth factor stimuli and nutrient availability. Amino acids or glucose facilitates mTORC1 activation by inducing RagA GTPase recruitment of mTORC1 to the lysosomal outer surface, enabling activation of mTOR by the Ras homolog Rheb. Thereby, RagA alters mTORC1-driven growth in times of nutrient abundance or scarcity. Here, we have evaluated differential nutrient-sensing dependence through RagA and mTORC1 in hematopoietic progenitors, which dynamically drive mature cell production, and hematopoietic stem cells (HSC), which provide a quiescent cellular reserve...
March 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28315777/appetite-disorders-in-cancer-patients-impact-on-nutritional-status-and-quality-of-life
#3
David E Barajas Galindo, Alfonso Vidal-Casariego, Alicia Calleja-Fernández, Ana Hernández-Moreno, Begoña Pintor de la Maza, Manuela Pedraza-Lorenzo, María Asunción Rodríguez-García, Dalia María Ávila-Turcios, Miran Alejo-Ramos, Rocío Villar-Taibo, Ana Urioste-Fondo, Isidoro Cano-Rodríguez, María D Ballesteros-Pomar
Cancer patients are at high risk of malnutrition due to several symptoms such as lack of appetite. The aim of this study was to determine the prevalence of different appetite disorders in cancer patients and their influence on dietary intake, nutritional status, and quality of life. We conducted a cross-sectional study of cancer patients at risk of malnutrition. Nutritional status was studied using Subjective Global Assessment, anthropometry, and grip strength. Dietary intake was evaluated with a 24-h recall, and patients were questioned about the presence of changes in appetite (none, anorexia, early satiety, or both)...
March 16, 2017: Appetite
https://www.readbyqxmd.com/read/28306219/characterization-of-a-novel-pold1-missense-founder-mutation-in-a-spanish-population
#4
Rosario Ferrer-Avargues, Virginia Díez-Obrero, Ester Martín-Tomás, Eva Hernández-Illán, María-Isabel Castillejo, Alan Codoñer-Alejos, Víctor-Manuel Barberá, Ana-Beatriz Sánchez-Heras, Ángel Segura, María-José Juan, Isabel Tena, Adela Castillejo, José-Luis Soto
BACKGROUND: We identified a new and a recurrent POLD1 mutation associated with predisposition to colorectal cancer (CRC). We characterized the molecular and clinical nature of the potential POLD1 founder mutation in families from Valencia (Spain). METHODS: Clinical and molecular data were collected from 4 independent families known to have a POLD1 Leu474Pro mutation. To establish its founder effect, haplotype construction was performed using 14 flanking POLD1 polymorphic markers...
March 17, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28296296/biplane-interventional-pediatric-system-with-cone-beam-ct-dose-and-image-quality-characterization-for-the-default-protocols
#5
Eva Corredoira, Eliseo Vañó, Luis Alejo, Carlos Ubeda, Federico Gutiérrez-Larraya, Julia Garayoa
The aim of this study was to assess image quality and radiation dose of a biplane angiographic system with cone-beam CT (CBCT) capability tuned for pediatric cardiac procedures. The results of this study can be used to explore dose reduction techniques. For pulsed fluoroscopy and cine modes, polymethyl methacrylate phantoms of various thicknesses and a Leeds TOR 18-FG test object were employed. Various fields of view (FOV) were selected. For CBCT, the study employed head and body dose phantoms, Catphan 504, and an anthropomorphic cardiology phantom...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28284963/a-structural-appraisal-of-sterol-carrier-protein-2
#6
REVIEW
Noelia I Burgardt, Alejo R Gianotti, Raúl G Ferreyra, Mario R Ermácora
Sterol Carrier Protein 2 (SCP2) has been associated with lipid binding and transfer activities. However, genomic, proteomic, and structural studies revealed that it is an ubiquitous domain of complex proteins with a variety functions in all forms of life. High-resolution structures of representative SCP2 domains are available, encouraging a comprehensive review of the structural basis for its success. Most SCP2 domains pertain to three major families and are frequently found as stand-alone or at the C-termini of lipid related peroxisomal enzymes, acetyltransferases causing bacterial resistance, and bacterial environmentally important sulfatases...
March 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28255652/attenuation-of-liver-cancer-development-by-oral-glycerol-supplementation-in-the-rat
#7
Alejo M Capiglioni, Florencia Lorenzetti, Ariel D Quiroga, Juan P Parody, María T Ronco, Gerardo B Pisani, María C Carrillo, María P Ceballos, María de Luján Alvarez
PURPOSE: Glycerol usage is increasing in food industry for human and animal nutrition. This study analyzed the impact of glycerol metabolism when orally supplemented during the early stage of rat liver carcinogenesis. METHODS: Wistar rats were subjected to a 2-phase model of hepatocarcinogenesis (initiated-promoted, IP group). IP animals also received glycerol by gavage (200 mg/kg body weight, IPGly group). RESULTS: Glycerol treatment reduced the volume of preneoplastic lesions by decreasing the proliferative status of liver foci, increasing the expression of p53 and p21 proteins and reducing the expression of cyclin D1 and cyclin-dependent kinase 1...
March 2, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28202586/waveform-sensitivity-of-electroreceptors-in-the-pulse-weakly-electric-fish-gymnotus-omarorum
#8
Alejo Rodríguez-Cattaneo, Pedro A Aguilera, Angel A Caputi
As in most sensory systems electrosensory images in weakly electric fish are encoded in two parallel pathways, fast and slow. From the work on wave type electric fish these pathways are thought to encode the time and amplitude of electrosensory signals respectively. This article focuses on the primary afferents giving origin to the slow path of the pulse type weakly electric fish Gymnotus omarorum We found that burst duration coders respond with a high-frequency train of spikes to each electric organ discharge...
February 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28151893/reproductive-history-before-and-after-hiv-diagnosis-a-cross-sectional-study-in-hiv-positive-women-in-spain
#9
Victoria Hernando, Belen Alejos, Marta Montero, MJesús Pérez-Elias, José Ramón Blanco, Livia Giner, Juan Luis Gómez-Sirvent, Jose Antonio Iribarren, Enrique Bernal, Francisco Bolumar
The aim of this study is to examine the reproductive history of human immunodeficiency virus (HIV)-positive women, before and after HIV diagnosis, to describe the characteristics of women with pregnancies after HIV diagnosis, and to assess the prevalence of mother-to-child transmission.A cross-sectional study was performed among women within reproductive ages (18-49) selected from the cohort in the Spanish AIDS Research Network (CoRIS). A descriptive analysis of the pregnancy outcomes was made according to women's serostatus at the moment of pregnancy and association of women's characteristics with having pregnancy after HIV diagnosis was evaluated using logistic regression models...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28112043/genetics-of-schizophrenia-a-consensus-paper-of-the-wfsbp-task-force-on-genetics
#10
Ina Giegling, Ladislav Hosak, Rainald Mössner, Alessandro Serretti, Frank Bellivier, Stephan Claes, David A Collier, Alejo Corrales, Lynn E DeLisi, Carla Gallo, Michael Gill, James L Kennedy, Marion Leboyer, Wolfgang Maier, Miguel Marquez, Isabelle Massat, Ole Mors, Pierandrea Muglia, Markus M Nöthen, Jorge Ospina-Duque, Michael J Owen, Peter Propping, YongYong Shi, David St Clair, Florence Thibaut, Sven Cichon, Julien Mendlewicz, Michael C O'Donovan, Dan Rujescu
OBJECTIVES: Schizophrenia is a severe psychiatric disease affecting about 1% of the general population. The relative contribution of genetic factors has been estimated to be up to 80%. The mode of inheritance is complex, non-Mendelian, and in most cases involving the combined action of large numbers of genes. METHODS: This review summarises recent efforts to identify genetic variants associated with schizophrenia detected, e.g., through genome-wide association studies, studies on copy-number variants or next-generation sequencing...
January 23, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28074986/-recommendations-for-the-management-of-pancreatic-cancer-type-adenocarcinoma-a-consensus-statement-reached-during-the-2015-latin-american-symposium-on-gastroenterological-oncology
#11
Christian Caglevic, Jorge Gallardo, Marcela de la Torre, Mauricio Mahave, Bettina Müller, Sebastián Solé, Yuri Moscoso, Hernán De La Fuente, Juan Carlos Roa, Sebastián Hoefler, Jean M Butte, Pablo González M, Juan Manuel O'Connor, Javiera Torres, Verónica Pérez Encalada, Daniel Alarcón Cano, Luis Ubillos, Christian Rolfo, Alejo Lingua, Consuelo Díaz Romero, Alejandro Padilla Rosciano, Viviana Cuartero, Germán Calderillo Ruiz, Gilberto Schwartsmann, Xavier Kon Jara, Andrés Andrade G, Luis Mas López, Olga Barajas, Marcela Carballido, Hanns Lembach, Lena Morillas G, Enrique Roca, José Lobatón, Paola Montenegro B, Andrés Yepes, Hugo Marsiglia
Pancreatic cancer is a malignancy of great impact in developed countries and is having an increasing impact in Latin America. Incidence and mortality rates are similar for this cancer. This is an important reason to offer to the patients the best treatments available. During the Latin American Symposium of Gastroenterology Oncology (SLAGO) held in Viña del Mar, Chile, in April 2015, a multidisciplinary group of specialists in the field met to discuss about this disease. The main conclusions of this meeting, where practitioners from most of Latin American countries participated, are listed in this consensus that seek to serve as a guide for better decision making for patients with pancreatic cancer in Latin America...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28059099/biological-relevance-of-human-papillomaviruses-in-vulvar-cancer
#12
Gordana Halec, Laia Alemany, Beatriz Quiros, Omar Clavero, Daniela Höfler, Maria Alejo, Wim Quint, Michael Pawlita, Francesc X Bosch, Silvia de Sanjose
The carcinogenic role of high-risk human papillomavirus (HR-HPV) types in the increasing subset of vulvar intraepithelial neoplasia and vulvar cancer in young women has been established. However, the actual number of vulvar cancer cases attributed to HPV is still imprecisely defined. In an attempt to provide a more precise definition of HPV-driven vulvar cancer, we performed HPV-type-specific E6*I mRNA analyses available for 20 HR-/possible HR (pHR)-HPV types, on tissue samples from 447 cases of vulvar cancer...
January 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28007310/persistence-of-zika-virus-in-semen-93-days-after-the-onset-of-symptoms
#13
Inés Oliveira Souto, Izaskun Alejo-Cancho, Joaquim Gascón Brustenga, Aida Peiró Mestres, Jose Muñoz Gutiérrez, Miguel J Martínez Yoldi
INTRODUCTION: Zika virus is mainly transmitted through the bites of infected Aedes mosquitoes, although mother-to-child and sexual transmission have also been described. The presence of Zika virus in semen after infection seems to be not uncommon, but the duration of viral persistence has not been well-determined. METHODS: Molecular, serological and cell culture methods were used for the diagnosis and follow up of a case of Zika virus infection imported from Venezuela...
December 19, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28001499/effectiveness-and-safety-of-methotrexate-in-psoriasis-an-8-year-experience-with-218-patients
#14
Camila Cabello Zurita, Mercè Grau Pérez, Carlos Pelayo Hernández Fernández, Alicia González Quesada, Pedro Valerón Almazán, Jaime Vilar Alejo, Gregorio Carretero Hernández
BACKGROUND: Methotrexate, a traditional antipsoriatic drug, is very frequently used either as monotherapy or in combination with other systemic drugs. OBJECTIVES: To assess the effectiveness and safety of Methotrexate in psoriasis in usual clinical practice. METHODS: We conducted a retrospective study. We performed an electronic and manual chart review of patients treated with Methotrexate in the Psoriasis Unit of our Hospital from January 2007 to December 2014...
December 21, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27995410/temporal-trends-in-mercury-concentrations-in-raptor-flight-feathers-stored-in-an-environmental-specimen-bank-in-galicia-nw-spain-between-2000-and-2013
#15
Rita García-Seoane, Zulema Varela, Alejo Carballeira, Jesús R Aboal, J Ángel Fernández
Temporal trends in Hg concentrations were investigated in primary flight feathers from 319 specimens of three birds of prey: P7 in the northern goshawk (Accipiter gentilis), P6 in the common buzzard (Buteo buteo) and P5 in the tawny owl (Strix aluco). The samples were stored in a regional environmental specimen bank and belonged to specimens which died between 2000 and 2013 in Galicia (NW Spain). We would expect to see a decline in Hg concentrations across the study period, as data of atmospheric emissions show a gradual reduction of this pollutant in Europe in the last two decades...
March 2017: Ecotoxicology
https://www.readbyqxmd.com/read/27988171/evaluation-of-a-rapid-immunochromatographic-test-for-the-detection-of-oxa-48-carbapenemase
#16
Elisa Rubio, Yuliya Zboromyrska, Cristina Pitart, Irene Campo, Izaskun Alejo-Cancho, Assumpta Fasanella, Andrea Vergara, Francesc Marco, Jordi Vila
We evaluated the OXA-48K-Set, a rapid immunochromatographic test for the detection of Oxacillinase-48 (OXA-48) carbapenemases, among 37 strains expressing OXA-48 and OXA-48-like carbapenemases and 20 additional strains harboring other β-lactamases. The test showed 100% sensitivity and specificity and the results were obtained in 15minutes.
March 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27955909/cardiovascular-operations-for-loeys-dietz-syndrome-intermediate-term-results
#17
Nishant D Patel, Todd Crawford, J Trent Magruder, Diane E Alejo, Narutoshi Hibino, James Black, Harry C Dietz, Luca A Vricella, Duke E Cameron
OBJECTIVES: Early experience with Loeys-Dietz syndrome (LDS) suggested an aggressive aortopathy with high risk of aneurysm dissection and rupture at young ages and at smaller aortic diameters than in other connective tissue disorders. We reviewed our experience with LDS to re-examine our indications and outcomes of surgical management. METHODS: We reviewed all patients with a diagnosis of LDS who underwent cardiovascular surgery at our institution. The primary endpoint was mortality, and secondary endpoints included postoperative complications and need for reintervention...
November 16, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27939208/evergreen-or-deciduous-trees-for-capturing-pahs-from-ambient-air-a-case-study
#18
Flavia De Nicola, Estefanía Concha Graña, Purificación López Mahía, Soledad Muniategui Lorenzo, Darío Prada Rodríguez, Rubén Retuerto, Alejo Carballeira, Jesús R Aboal, J Ángel Fernández
Tree canopies play a key role in the cycling of polycyclic aromatic hydrocarbons (PAHs) in terrestrial ecosystems, as leaves can capture PAHs from the air. In this study, accumulation of PAHs was compared in an evergreen species, P. pinaster, and in a deciduous species, Q. robur, in relation to some physio-morphological characteristics. For this purpose, pine needles and oak leaves collected from different sites across Galicia (NW Spain) were analysed to determine PAH contents, specific leaf area, stomatal density and conductance...
February 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27927490/results-of-the-scoliosis-research-society-morbidity-and-mortality-database-2009-2012-a-report-from-the-morbidity-and-mortality-committee
#19
Douglas C Burton, Brandon B Carlson, Howard M Place, Jonathan E Fuller, Kathy Blanke, Robert Cho, Kai-Ming Fu, Aruna Ganju, Robert Heary, Jose A Herrera-Soto, A Noelle Larson, William F Lavelle, Ian W Nelson, Alejo Vernengo-Lezica, Joseph M Verska
INTRODUCTION: Members of the Scoliosis Research Society are required to annually submit complication data regarding deaths, visual acuity loss, neurological deficit and infection (2012-1st year for this measure) for all deformity operations performed. The purpose of this study is to report the 2012 results and the differences in these complications from the years 2009-2012. METHODS: The SRS M&M database is a self-reported complications registry of deformity operations performed by the members...
September 2016: Spine Deformity
https://www.readbyqxmd.com/read/27918148/influenza-a-virus-surveillance-in-the-invasive-american-mink-neovison-vison-from-freshwater-ecosystems-northern-spain
#20
H Gholipour, N Busquets, X Fernández-Aguilar, A Sánchez, M P Ribas, G De Pedro, P Lizarraga, O Alarcia-Alejos, C Temiño, O Cabezón
Influenza A viruses (IAVs) are negative-sense, single-stranded and segmented RNA viruses of the Orthomyxoviridae family that may cause acute respiratory disease in a wide range of birds and mammals. Susceptibility of several species within the family Mustelidae to IAVs has been reported as a result of natural or experimental infections. The objectives of this study were to assess whether free-ranging American mink populations from Northern Spain were infected with IAV and try to define the role of this species in the epidemiology of IAV...
December 5, 2016: Zoonoses and Public Health
keyword
keyword
85791
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"