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tenofovir prophilaxis

Michele Merli, Sara Rattotti, Manuel Gotti, Luca Arcaini
In patients with lymphoma the detection of positive hepatitis B or C viruses (HBV and HCV) serology involves crucial therapeutic consequences. In HBV-infected patients the serological profile of active (HBsAg-positive) or resolved (HBsAg-negative/anti-HBcAb-positive) infection is associated to differential risk of viral reactivation during rituximab-based therapy and require appropriate strategies of monitoring and of antiviral prophylaxis. In HCV-associated NHL patients consolidated data demonstrated that interferon (IFN)-based antiviral therapy (AT) is able to induce lymphoma regression strictly related to viral eradication, while preliminary data of the new direct-acting antivirals (DAAs) are very promising...
March 2017: Expert Opinion on Pharmacotherapy
Melissa Padovan, Matteo Filippini, Angela Tincani, Elisabetta Lanciano, Eleonora Bruschi, Oscar Epis, Pietro Garau, Alessandro Mathieu, Eleonora Celletti, Leopoldo Giani, Paola Tomietto, Fabiola Atzeni, Piercarlo Sarzi Puttini, Francesca Zuliani, Salvatore De Vita, Francesco Trotta, Anastasio Grilli, Massimo Puoti, Marcello Govoni
OBJECTIVE: Rheumatoid arthritis (RA) with concomitant hepatitis B virus (HBV) infection represents a therapeutic challenge due to the risk of HBV reactivation under immunosuppressive treatment. To date there are few data coming from anecdotal case reports that concern HBV reactivation following treatment with abatacept. This observational retrospective study was aimed to assess the safety profile of abatacept in this particular clinical setting. METHODS: Eleven Italian rheumatologic centers provided data from patients with RA and positive HBV serology treated with intravenous abatacept...
June 2016: Arthritis Care & Research
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