Luisa Canè, Remo Poto, Francesco Palestra, Marinella Pirozzi, Seetharaman Parashuraman, Ilaria Iacobucci, Anne Lise Ferrara, Antonello La Rocca, Edoardo Mercadante, Piero Pucci, Gianni Marone, Maria Monti, Stefania Loffredo, Gilda Varricchi
BACKGROUND: Macrophages are the predominant immune cells in the human lung and play a central role in airway inflammation, including asthma and chronic obstructive pulmonary disease (COPD). Thymic stromal lymphopoietin (TSLP), a pleiotropic cytokine mainly expressed by bronchial epithelial cells, plays a key role in asthma and COPD pathobiology. TSLP exists in two variants: the long form (lfTSLP) and a shorter TSLP isoform (sfTSLP). We aimed to localize TSLP in human lung macrophages (HLMs) and investigate the mechanisms of its release from these cells...
February 23, 2024: European Journal of Internal Medicine