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mast cell activation disorder

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https://www.readbyqxmd.com/read/29165303/immunoreactivity-to-cyp24a1-but-not-vitamin-d-receptor-is-increased-in-mast-cells-of-keratinocyte-skin-cancers
#1
Antti Kaukinen, Hanna Siiskonen, Jukka Pelkonen, Ilkka T Harvima
In mouse skin models, mast cells have been shown to express vitamin D receptor (VDR) that can mediate the immunosuppressive effects of ultraviolet B radiation and vitamin D3. However, VDR activation leads to the expression of CYP24A1, a hydroxylase that can inactivate vitamin D3 metabolites. To examine immunoreactivity to VDR and CYP24A1 in mast cells from normal human skin, keratinocyte skin cancers, and disorders of chronic inflammation. Frozen biopsies were collected from the non-lesional and lesional skin of patients with actinic keratosis (AK), Bowen's disease/squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and psoriasis...
November 22, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29155995/lysosome-biogenesis-regulated-by-the-amino-acid-transporter-slc15a4-is-critical-for-functional-integrity-of-mast-cells
#2
Toshihiko Kobayashi, Hidemitsu Tsutsui, Shiho Shimabukuro-Demoto, Reiko Sugitani-Yoshida, Hitomi Karyu, Kaori Furuyama-Tanaka, Daisuke Ohshima, Norihiro Kato, Tadashi Okamura, Noriko Toyama Sorimachi
Mast cells possess specialized lysosomes, so-called secretory granules, which play a key role not only in allergic responses but also in various immune disorders. The molecular mechanisms that control secretory-granule formation are not fully understood. Solute carrier family member 15A4 (SLC15A4) is a lysosome-resident amino-acid/oligopeptide transporter that is preferentially expressed in hematopoietic-lineage cells. Here we demonstrated that SLC15A4 is required for mast-cell secretory granule homeostasis, and limits mast-cell functions and inflammatory responses by controlling the mTORC1-TFEB signaling axis...
November 15, 2017: International Immunology
https://www.readbyqxmd.com/read/29132542/impact-of-inflammation-on-the-blood-neural-barrier-and-blood-nerve-interface-from-review-to-therapeutic-preview
#3
Stephen D Skaper
A number of nervous system disorders are characterized by a state of inflammation (neuroinflammation) in which members of the innate immune system, most notably mast cells and microglia-acting as single entities and in unison-produce inflammatory molecules that play major roles. A neuroinflammatory environment can weaken not only blood-nerve and blood-brain barrier (BBB) integrity but also that of the blood-spinal cord barrier. Mast cells, with their distribution in peripheral nerves and the central nervous system, are positioned to influence blood-nerve barrier characteristics...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/29105783/clinical-implications-of-mast-cell-involvement-in-allergic-conjunctivitis
#4
REVIEW
D Elieh Ali Komi, T Rambasek, L Bielory
The conjunctiva is a common site for the allergic inflammatory response due to it being highly vascularized, having constant exposure to environmental pollutants and allergenic pollens and having a unique conjunctival associated lymphoid tissue. The primary morbidity of anterior surface conjunctival disorders that include allergic conjunctivitis and tear film disorders is associated with its high frequency of involvement rather than its severity, although the more chronic forms can involve the cornea and lead to sight-threatening conditions...
November 6, 2017: Allergy
https://www.readbyqxmd.com/read/29083538/functional-dyspepsia-and-duodenal-eosinophilia-a-new-disease-model
#5
REVIEW
Kening Fan, Nicholas J Talley
Functional dyspepsia (FD) is a highly prevalent disorder that affects more than 10% of the population. In the past decade, the conceptual underpinning of FD has begun to change, and new data are unraveling the underlying pathophysiological mechanisms of this disorder with a focus on the duodenum. The Rome IV criteria were published in 2016, and notably suggests that gastroesophageal reflux disease and irritable bowel syndrome may all be part of the same disease spectrum as FD. Helicobacter pylori explains a minority of FD cases and in Rome IV is considered a separate entity...
October 30, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29081091/rifampicin-alleviates-atopic-dermatitis-like-response-in-vivo-and-in-vitro
#6
Seung Hyun Kim, Ki Man Lee, Geum Seon Lee, Ju-Won Seong, Tae Jin Kang
Atopic dermatitis (AD) is a common inflammatory skin disorder mediated by inflammatory cells, such as macrophages and mast cells. Rifampicin is mainly used for the treatment of tuberculosis. Recently, it was reported that rifampicin has anti-inflammatory and immune-suppressive activities. In this study, we investigated the effect of rifampicin on atopic dermatitis in vivo and in vitro. AD was induced by treatment with 2, 4-dinitrochlorobenzene (DNCB) in NC/Nga mice. A subset of mice was then treated with rifampicin by oral administration...
November 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29064119/in-chronic-spontaneous-urticaria-high-numbers-of-dermal-endothelial-cells-but-not-mast-cells-are-linked-to-recurrent-angio-oedema
#7
D Terhorst, I Koti, K Krause, M Metz, M Maurer
BACKGROUND: Chronic spontaneous urticaria (CSU) is an inflammatory skin disorder characterized by recurrent weals, angio-oedema or both. Recent studies have shown that the number of endothelial cells is increased in the skin of patients with CSU, but the underlying mechanisms and clinical implications of this are unclear. AIM: To evaluate whether mast cell (MC) or endothelial cell (EC) numbers correlate with CSU and whether they are relevant for disease duration, disease activity or the presence of clinical features...
October 24, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29042288/mast-cell-degranulation-and-calcium-influx-are-inhibited-by-an-echinacea-purpurea-extract-and-the-alkylamide-dodeca-2e-4e-dienoic-acid-isobutylamide
#8
Travis V Gulledge, Nicholas M Collette, Emily Mackey, Stephanie E Johnstone, Yasamin Moazami, Daniel A Todd, Adam J Moeser, Joshua G Pierce, Nadja B Cech, Scott M Laster
ETHNOPHARMACOLOGICAL RELEVANCE: Native Americans used plants from the genus Echinacea to treat a variety of different inflammatory conditions including swollen gums, sore throats, skin inflammation, and gastrointestinal disorders. Today, various Echinacea spp. preparations are used primarily to treat upper respiratory infections. AIM OF THE STUDY: The goal of this study was to evaluate the effects of an ethanolic E. purpurea (L) Moench root extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide (A15) on mast cells, which are important mediators of allergic and inflammatory responses...
October 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29034737/anti-allergic-inflammatory-effect-of-vanillic-acid-through-regulating-thymic-stromal-lymphopoietin-secretion-from-activated-mast-cells
#9
Hyun-Ja Jeong, Sun-Young Nam, Hee-Yun Kim, Mu Hyun Jin, Mi Hye Kim, Seok Seon Roh, Hyung-Min Kim
Vanillic acid, which is well known as a benzoic acid derivative, has been used as a flavouring agent. Currently, we ascertained the therapeutic potential action of vanillic acid on allergic inflammatory reaction in human mast cell line, HMC-1. Treatment with vanillic acid resulted in a significant decrease in levels of thymic stromal lymphopoietin and pro-inflammatory cytokines compared to phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-treated HMC-1 cells. In PMACI-stimulated cells, treatment with vanillic acid also dramatically inhibited activities of caspase-1 and nuclear factor-kB (p65)...
October 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29031900/resveratrol-improved-detrusor-fibrosis-induced-by-mast-cells-during-progression-of-chronic-prostatitis-in-rats
#10
Yi He, Huizhi Zeng, Yang Yu, Jiashu Zhang, Qi Liu, Bo Yang
To investigate the detrusor fibrosis and urinary dysfunction in chronic prostatitis (CP), and to investigate whether resveratrol can improve the urinary dysfunction and the underlying molecular mechanism. After rat model of CP is established by subcutaneously injecting DPT vaccine, rats are treated with resveratrol. Experiments of bladder pressure and volume test in rats are used to investigate the effect of resveratrol on urinary dysfunction in CP rats. To assess tissue fibrosis, picrosirius red staining is performed...
October 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29031599/interaction-of-dj-1-with-lyn-is-essential-for-ige-mediated-stimulation-of-human-mast-cells
#11
Do-Kyun Kim, Michael A Beaven, Dean D Metcalfe, Ana Olivera
BACKGROUND: DJ-1 is a redox-sensitive protein with multiple roles in cell homeostasis whose levels are altered in mast cell (MC)-related disorders. However, whether DJ-1 can regulate human MC function is unknown. OBJECTIVE: We sought to investigate the potential role of DJ-1 in the responses of human MCs to antigen stimulation. METHODS: DJ-1 was silenced in human CD34(+)-derived and LAD2 MCs using lentiviral sh-RNA constructs. Release of β-hexosaminidase, PGD2 and GM-CSF and changes in reactive oxygen species (ROS) levels were measured after FcεRI engagement...
October 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28993062/chronic-spontaneous-urticaria-and-the-extrinsic-coagulation-system
#12
REVIEW
Yuhki Yanase, Shunsuke Takahagi, Michihiro Hide
Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch. Recently, the activation of the blood coagulation cascade has been suggested to be involved in CSU, but the trigger of the coagulation cascade remains unclear. In this article, we review recent understanding of the relationship between the pathogenesis of CSU and extrinsic coagulation reactions. In CSU, vascular endothelial cells and eosinophils may play a role as TF-expressing cells for activating the extrinsic coagulation pathway...
October 6, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28990098/anti%C3%A2-inflammatory-effect-of-amomum%C3%A2-xanthioides-in-a-mouse-atopic-dermatitis-model
#13
Young-Ae Choi, Jin Kyeong Choi, Yong Hyun Jang, Soyoung Lee, Sang-Rae Lee, Jung Ho Choi, Jee Hun Park, Tae-Yong Shin, Sang-Hyun Kim
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. The present study investigated the effects of Amomum xanthioides extract (AXE) on AD‑like skin inflammation using a Dermatophagoides farinae extract (DFE) and 2,4‑dinitrochlorobenzene (DNCB)‑induced mouse AD model. Hematoxylin and eosin staining results demonstrated that repeated DFE/DNCB exposure markedly increased the thickening of the dermis and epidermis, in addition to the infiltration of eosinophils and mast cells. However, oral administration of AXE reduced these histopathological alterations in a dose‑dependent manner...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28986986/depletion-of-mast-cells-and-macrophages-impairs-heterotopic-ossification-in-an-acvr1-r206h-mouse-model-of-fibrodysplasia-ossificans-progressiva
#14
Michael R Convente, Salin A Chakkalakal, EnJun Yang, Robert J Caron, Deyu Zhang, Taku Kambayashi, Frederick S Kaplan, Eileen M Shore
Heterotopic ossification (HO) is a clinical condition that often reduces mobility and diminishes quality of life for affected individuals. The most severe form of progressive HO occurs in those with fibrodysplasia ossificans progressiva (FOP; OMIM #135100), a genetic disorder caused by a recurrent heterozygous gain-of-function mutation (R206H) in the bone morphogenetic protein (BMP) type I receptor ACVR1/ALK2. In individuals with FOP, episodes of HO frequently follow injury. The first sign of active disease is commonly an inflammatory "flare-up" that precedes connective tissue degradation, progenitor cell recruitment, and endochondral HO...
October 7, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28980852/mast-cell-mediators-inhibit-osteoblastic-differentiation-and-extracellular-matrix-mineralization
#15
William Marcatti Amarú Maximiano, Elaine Zayas Marcelino da Silva, Ana Carolina Santana, Paulo Tambasco de Oliveira, Maria Célia Jamur, Constance Oliver
Mast cells are multifunctional immune cells that participate in many important processes such as defense against pathogens, allergic reactions, and tissue repair. These cells perform their functions through the release of a wide variety of mediators. This release occurs mainly through cross-linking IgE (immunoglobulin E) bound to high affinity IgE receptors by multivalent antigens. The abundance of mast cells in connective tissue, surrounding blood vessels, and their involvement in the early stages of bone repair support the possibility of physiological and pathological interactions between mast cells and osteoblasts...
October 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/28977053/large-accumulation-of-collagen-and-increased-activation-of-mast-cells-in-hearts-of-mice-with-hyperlipidemia
#16
Yunpeng Cheng, Yanqiu Zhu, Jiashu Zhang, Xingping Duan, Ying Zhang
BACKGROUND: Hyperlipidemia, which is characterized by an elevation of lipids in the bloodstream, is a major risk factor for cardiac disease. OBJECTIVES: The present study investigated the role of fibrosis in the progression of hyperlipidemia in the mice heart, and whether mast cell activation was associated with the fibrosis process. METHODS: Hyperlipidemia was produced in C57BL / 6 mice by feeding them on a high-fat diet for 8 weeks.To assess tissue fibrosis, picrosirius red staining was performed...
September 28, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28970014/impact-of-mast-cells-in-mucosal-immunity-of-intestinal-inflammation-inhibitory-effect-of-il-37
#17
REVIEW
Pio Conti, Alessandro Caraffa, Gianpaolo Ronconi, Spiros K Kritas, Filiberto Mastrangelo, Lucia Tettamanti, Theoharis C Theoharides
Mast cells (MCs) are implicated in an array of diseases, especially those involving a mucosal surface, including intestine. On appropriate activation from cytoplasmatic granules, MCs release preformed chemical mediators and generate inflammatory lipids and cytokines/chemokines. Intracellular signal and Lyn activation pathways can cause the degranulation of MCs and the generation of lipid mediators and cytokines/chemokines. MCs undergo maturation and polarization in gut mucosal surfaces where they are constitutively present, and can alter intestinal permeability, an important factor in many inflammatory mucosal disorders including autoimmune diseases...
September 29, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28966616/factor-xii-driven-inflammatory-reactions-with-implications-for-anaphylaxis
#18
REVIEW
Lysann Bender, Henri Weidmann, Stefan Rose-John, Thomas Renné, Andy T Long
Anaphylaxis is a life-threatening allergic reaction. It is triggered by the release of pro-inflammatory cytokines and mediators from mast cells and basophils in response to immunologic or non-immunologic mechanisms. Mediators that are released upon mast cell activation include the highly sulfated polysaccharide and inorganic polymer heparin and polyphosphate (polyP), respectively. Heparin and polyP supply a negative surface for factor XII (FXII) activation, a serine protease that drives contact system-mediated coagulation and inflammation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28920040/parasympathetic-cholinergic-and-neuropeptide-mechanisms-of-migraine
#19
REVIEW
Nikita Mikhailov, Oleg V Mamontov, Alexei A Kamshilin, Rashid Giniatullin
CONTEXT: Migraine mechanisms remain largely uncovered for various reasons including a very high complexity of the neurophysiological mechanisms implicated in this disorder and a plethora of endogenous biologically active compounds involved in the pathological process. The functional role of parasympathetic innervation of meninges and cholinergic mechanisms of migraine are among little explored issues despite multiple evidence indirectly indicating the role of acetylcholine (ACh) and its analogues in migraine and other types of headache...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28901381/anti%C3%A2-allergic-action-of-bacillus-calmette%C3%A2-guerin-extract-in-experimental-mast-cell%C3%A2-mediated-anaphylactic-models
#20
Mingli Sun, Yong Wang, Haishan Zhao, Weifan Yao, Xiaosong Yu
Allergy is an acquired hypersensitivity reaction of the immune system mediated by IgE‑induced mast cell degranulation. In China, bacillus Calmette‑Guerin extract (BCGE) has been shown to be clinically effective for regulating immunity, which enhances the resistance of the body to anaphylactic disease, infectious diseases and cancer. However, the mechanisms remain to be fully elucidated. The present study investigated the potential anti‑allergic effects of BCGE in animal models of mast cell‑dependent anaphylaxis and mechanisms of BCGE in mast cells...
November 2017: Molecular Medicine Reports
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