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https://www.readbyqxmd.com/read/29673467/transition-intervention-for-adolescents-with-congenital-heart-disease
#1
Andrew S Mackie, Gwen R Rempel, Adrienne H Kovacs, Miriam Kaufman, Kathryn N Rankin, Ahlexxi Jelen, Maryna Yaskina, Renee Sananes, Erwin Oechslin, Dimi Dragieva, Sonila Mustafa, Elina Williams, Michelle Schuh, Cedric Manlhiot, Samantha J Anthony, Joyce Magill-Evans, David Nicholas, Brian W McCrindle
BACKGROUND: There is little evidence regarding the efficacy of interventions to prepare adolescents with congenital heart disease (CHD) to enter adult care. OBJECTIVES: The goal of this study was to evaluate the impact of a nurse-led transition intervention on lapses between pediatric and adult care. METHODS: A cluster randomized clinical trial was conducted of a nurse-led transition intervention for 16- to 17-year-olds with moderate or complex CHD versus usual care...
April 24, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29626689/petrous-face-meningiomas-classification-clinical-syndromes-and-surgical-outcomes
#2
Stephen T Magill, Jonathan W Rick, William C Chen, David A Haase, David R Raleigh, Manish K Aghi, Philip V Theodosopoulos, Michael W McDermott
BACKGROUND: Petrous face meningiomas (PFM) are challenging tumors due to their proximity to the cranial nerves, brainstem and critical vasculature. The objective of this study is to present surgical outcomes and support an anatomic classification for PFM based on clinical presentation. METHODS: A retrospective chart review was performed, and 51 PFM were identified. Tumors were classified by location along the petrous face into anterior, middle and posterior. Presentation and outcomes were analyzed with logistic regression...
April 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29624151/histopathological-features-predictive-of-local-control-of-atypical-meningioma-after-surgery-and-adjuvant-radiotherapy
#3
William C Chen, Stephen T Magill, Ashley Wu, Harish N Vasudevan, Olivier Morin, Manish K Aghi, Philip V Theodosopoulos, Arie Perry, Michael W McDermott, Penny K Sneed, Steve E Braunstein, David R Raleigh
OBJECTIVE The goal of this study was to investigate the impact of adjuvant radiotherapy (RT) on local recurrence and overall survival in patients undergoing primary resection of atypical meningioma, and to identify predictive factors to inform patient selection for adjuvant RT. METHODS One hundred eighty-two patients who underwent primary resection of atypical meningioma at a single institution between 1993 and 2014 were retrospectively identified. Patient, meningioma, and treatment data were extracted from the medical record and compared using the Kaplan-Meier method, log-rank tests, multivariate analysis (MVA) Cox proportional hazards models with relative risk (RR), and recursive partitioning analysis...
April 6, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29622327/imaging-gently
#4
REVIEW
Amy L Puchalski, Christyn Magill
Advances in medical imaging are invaluable in the care of pediatric patients in the emergent setting. The diagnostic accuracy offered by studies using ionizing radiation, such as plain radiography, computed tomography, and fluoroscopy, are not without inherent risks. This article reviews the evidence supporting the risk of ionizing radiation from medical imaging as well as discusses clinical scenarios in which clinicians play an important role in supporting the judicious use of imaging studies.
May 2018: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/29606048/relationship-between-tumor-location-size-and-who-grade-in-meningioma
#5
Stephen T Magill, Jacob S Young, Ricky Chae, Manish K Aghi, Philip V Theodosopoulos, Michael W McDermott
OBJECTIVE Prior studies have investigated preoperative risk factors for meningioma; however, no association has been shown between meningioma tumor size and tumor grade. The objective of this study was to investigate the relationship between tumor size and grade in a large single-center study of patients undergoing meningioma resection. METHODS A retrospective chart review of patients undergoing meningioma resection at the University of California, San Francisco, between 1985 and 2015 was performed. Patients with incomplete information, spinal meningiomas, multiple meningiomas, or WHO grade III meningiomas were excluded...
April 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29606045/tuberculum-sellae-meningiomas-grading-scale-to-assess-surgical-outcomes-using-the-transcranial-versus-transsphenoidal-approach
#6
Stephen T Magill, Ramin A Morshed, Calixto-Hope G Lucas, Manish K Aghi, Philip V Theodosopoulos, Mitchel S Berger, Oreste de Divitiis, Domenico Solari, Paolo Cappabianca, Luigi M Cavallo, Michael W McDermott
OBJECTIVE Tuberculum sellae meningiomas (TSMs) are surgically challenging tumors that can severely impair vision. Debate exists regarding whether the transcranial (TC) or endoscopic transsphenoidal (TS) approach is best for resecting these tumors, and there are few large series comparing these approaches. METHODS A retrospective chart review was performed at 2 academic centers comparing TC and TS approaches with respect to vision, extent of resection, recurrence, and complications. The authors report surgical outcomes and propose a simple preoperative tumor grading scale that scores tumor size (1-2), optic canal invasion (0-2), and arterial encasement (0-2)...
April 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29596017/mechanisms-for-the-increased-fatigability-of-the-lower-limb-in-people-with-type-2-diabetes
#7
Jonathon Senefeld, Steven B Magill, April Harkins, Alison Rosemary Harmer, Sandra K Hunter
Fatiguing exercise is the basis of exercise training and a cornerstone of management of type 2 diabetes mellitus (T2D), however, little is known about the fatigability of limb muscles and the involved mechanisms in people with T2D. The purpose was to compare fatigability of knee extensor muscles between people with T2D and controls without diabetes and determine the neural and muscular mechanisms for a dynamic fatiguing task. Seventeen people with T2D (10 men, 7 women: 59.6{plus minus}9.0 years) and 21 age-, BMI- and physical activity-matched controls (11 men, 10 women: 59...
March 29, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29590631/comprehensive-molecular-profiling-identifies-foxm1-as-a-key-transcription-factor-for-meningioma-proliferation
#8
Harish N Vasudevan, Steve E Braunstein, Joanna J Phillips, Melike Pekmezci, Bryan A Tomlin, Ashley Wu, Gerald F Reis, Stephen T Magill, Jie Zhang, Felix Y Feng, Theodore Nicholaides, Susan M Chang, Penny K Sneed, Michael W McDermott, Mitchel S Berger, Arie Perry, David R Raleigh
Meningioma is the most common primary intracranial tumor, but the molecular drivers of aggressive meningioma are incompletely understood. Using 280 human meningioma samples and RNA sequencing, immunohistochemistry, whole-exome sequencing, DNA methylation arrays, and targeted gene expression profiling, we comprehensively define the molecular profile of aggressive meningioma. Transcriptomic analyses identify FOXM1 as a key transcription factor for meningioma proliferation and a marker of poor clinical outcomes...
March 27, 2018: Cell Reports
https://www.readbyqxmd.com/read/29576454/profound-tissue-specificity-in-proliferation-control-underlies-cancer-drivers-and-aneuploidy-patterns
#9
Laura Magill Sack, Teresa Davoli, Mamie Z Li, Yuyang Li, Qikai Xu, Kamila Naxerova, Eric C Wooten, Ronald J Bernardi, Timothy D Martin, Ting Chen, Yumei Leng, Anthony C Liang, Kathleen A Scorsone, Thomas F Westbrook, Kwok-Kin Wong, Stephen J Elledge
Genomics has provided a detailed structural description of the cancer genome. Identifying oncogenic drivers that work primarily through dosage changes is a current challenge. Unrestrained proliferation is a critical hallmark of cancer. We constructed modular, barcoded libraries of human open reading frames (ORFs) and performed screens for proliferation regulators in multiple cell types. Approximately 10% of genes regulate proliferation, with most performing in an unexpectedly highly tissue-specific manner. Proliferation drivers in a given cell type showed specific enrichment in somatic copy number changes (SCNAs) from cognate tumors and helped predict aneuploidy patterns in those tumors, implying that tissue-type-specific genetic network architectures underlie SCNA and driver selection in different cancers...
March 20, 2018: Cell
https://www.readbyqxmd.com/read/29553347/mechanisms-of-behavior-change-within-peer-implemented-alcohol-interventions
#10
Erica M Eaton, Molly Magill, Christy Capone, Margaret A Cramer, Nadine R Mastroleo, Racheal Reavy, Brian Borsari
OBJECTIVE: Colleges continue to experience a high number of referred students because of campus alcohol violations. Subsequently, there has been a trend to use peer-implemented minimal interventions (PMIs), often using motivational interviewing (MI). However, little is known about how PMIs facilitate behavior change. This study aims to examine the mechanisms of behavior change within PMIs and their influence on alcohol reduction among mandated students. METHOD: Participants (N = 146; mean age = 18...
March 2018: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/29503868/einstein-home-discovers-a-radio-quiet-gamma-ray-millisecond-pulsar
#11
Colin J Clark, Holger J Pletsch, Jason Wu, Lucas Guillemot, Matthew Kerr, Tyrel J Johnson, Fernando Camilo, David Salvetti, Bruce Allen, David Anderson, Carsten Aulbert, Christian Beer, Oliver Bock, Andres Cuéllar, Heinz-Bernd Eggenstein, Henning Fehrmann, Michael Kramer, Shawn A Kwang, Bernd Machenschalk, Lars Nieder, Markus Ackermann, Marco Ajello, Luca Baldini, Jean Ballet, Guido Barbiellini, Denis Bastieri, Ronaldo Bellazzini, Elisabetta Bissaldi, Roger D Blandford, Elliott D Bloom, Raffaella Bonino, Eugenio Bottacini, Terri J Brandt, Johan Bregeon, Philippe Bruel, Rolf Buehler, Toby H Burnett, Sara Buson, Rob A Cameron, Regina Caputo, Patrizia A Caraveo, Elisabetta Cavazzuti, Claudia Cecchi, Eric Charles, Alexandre Chekhtman, Stefano Ciprini, Lynn R Cominsky, Denise Costantin, Sara Cutini, Filippo D'Ammando, Andrea De Luca, Rachele Desiante, Leonardo Di Venere, Mattia Di Mauro, Niccolò Di Lalla, Seth W Digel, Cecilia Favuzzi, Elizabeth C Ferrara, Anna Franckowiak, Yasushi Fukazawa, Stefan Funk, Piergiorgio Fusco, Fabio Gargano, Dario Gasparrini, Nico Giglietto, Francesco Giordano, Marcello Giroletti, Germán A Gomez-Vargas, David Green, Isabelle A Grenier, Sylvain Guiriec, Alice K Harding, John W Hewitt, Deirdre Horan, Guðlaugur Jóhannesson, Shiki Kensei, Michael Kuss, Giovanni La Mura, Stefan Larsson, Luca Latronico, Jian Li, Francesco Longo, Francesco Loparco, Michael N Lovellette, Pasquale Lubrano, Jeffrey D Magill, Simone Maldera, Alberto Manfreda, Mario N Mazziotta, Julie E McEnery, Peter F Michelson, Nestor Mirabal, Warit Mitthumsiri, Tsunefumi Mizuno, Maria Elena Monzani, Aldo Morselli, Igor V Moskalenko, Eric Nuss, Takashi Ohsugi, Nicola Omodei, Monica Orienti, Elena Orlando, Michele Palatiello, Vaidehi S Paliya, Francesco de Palma, David Paneque, Jeremy S Perkins, Massimo Persic, Melissa Pesce-Rollins, Troy A Porter, Giacomo Principe, Silvia Rainò, Riccardo Rando, Paul S Ray, Massimiliano Razzano, Anita Reimer, Olaf Reimer, Roger W Romani, Pablo M Saz Parkinson, Carmelo Sgrò, Eric J Siskind, David A Smith, Francesca Spada, Gloria Spandre, Paolo Spinelli, Jana B Thayer, David J Thompson, Diego F Torres, Eleonora Troja, Giacomo Vianello, Kent Wood, Matthew Wood
Millisecond pulsars (MSPs) are old neutron stars that spin hundreds of times per second and appear to pulsate as their emission beams cross our line of sight. To date, radio pulsations have been detected from all rotation-powered MSPs. In an attempt to discover radio-quiet gamma-ray MSPs, we used the aggregated power from the computers of tens of thousands of volunteers participating in the Einstein@Home distributed computing project to search for pulsations from unidentified gamma-ray sources in Fermi Large Area Telescope data...
February 2018: Science Advances
https://www.readbyqxmd.com/read/29480505/salvage-therapy-outcomes-for-atypical-meningioma
#12
William C Chen, Jared Hara, Stephen T Magill, Ashley Wu, Manish K Aghi, Philip V Theodosopoulos, Arie Perry, Michael W McDermott, Penny K Sneed, David R Raleigh, Steve E Braunstein
Atypical menginomas demonstrate increased clinical aggressiveness characterized by recurrence and diminished survival. The optimal management of atypical meningioma in the recurrent setting is especially not well defined. To characterize outcomes following salvage treatment of recurrent atypical meningioma and to identify risk factors for further recurrence. Retrospective chart review was performed on 65 patients who underwent salvage treatment of atypical meningioma at a single institution. Data were analyzed using the Kaplan-Meier method and Cox proportional hazards modeling...
February 26, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29478081/hybrid-mr-pet-of-brain-tumours-using-amino-acid-pet-and-chemical-exchange-saturation-transfer-mri
#13
N A da Silva, P Lohmann, J Fairney, A W Magill, A-M Oros Peusquens, C-H Choi, R Stirnberg, G Stoffels, N Galldiks, X Golay, K-J Langen, N Jon Shah
PURPOSE: PET using radiolabelled amino acids has become a promising tool in the diagnostics of gliomas and brain metastasis. Current research is focused on the evaluation of amide proton transfer (APT) chemical exchange saturation transfer (CEST) MR imaging for brain tumour imaging. In this hybrid MR-PET study, brain tumours were compared using 3D data derived from APT-CEST MRI and amino acid PET using O-(2-18 F-fluoroethyl)-L-tyrosine (18 F-FET). METHODS: Eight patients with gliomas were investigated simultaneously with18 F-FET PET and APT-CEST MRI using a 3-T MR-BrainPET scanner...
February 24, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29432588/method-for-occupational-skin-dose-estimation-in-upper-extremity-131i-mibg-contamination
#14
Dennise Magill, Natalie Beckmann, Marc Felice, Megan Harkins
This study examines upper extremity skin contamination of nuclear medicine and radiation safety staff during 131I-Metaiodobenzylguanidine (MIBG) therapy. Utilizing retrospective data, a methodology for performing a rapid assessment of the radiation dose to the skin of the upper extremities is presented. Using the skin contamination measurements and calculated skin dose for each contamination incident at our facility, a conversion factor (XE) was derived that estimates skin dose (DE) based on the initial contamination measurement...
February 8, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29416256/use-of-the-magill-forceps-as-an-aid-for-i-gel%C3%A2-removal-after-endotracheal-intubation-a-safe-and-simple-technique
#15
Julian Arevalo Ludeña, Luis Enrique Muñoz Alameda
No abstract text is available yet for this article.
October 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29401075/comparison-of-nasal-intubations-by-glidescope-with-and-without-a-bougie-guide-in-patients-who-underwent-maxillofacial-surgeries-randomized-clinical-trial
#16
Pejman Pourfakhr, Ailar Ahangari, Farhad Etezadi, Reza Shariat Moharari, Ayat Ahmadi, Negin Saeedi, Atabak Najafi
BACKGROUND: Nasotracheal intubation is commonly performed to provide a secure airway for the maintenance of general anesthesia in maxillofacial surgeries. Routine nasotracheal intubation is performed under general anesthesia by direct laryngoscopy, frequently with the aid of Magill forceps. This method can be time-consuming and may cause bleeding in the field of view. A gum elastic bougie (GEB) is a cheap, slender, and flexible device that could expedite nasotracheal intubation. The aim of this study was to evaluate the use of a GEB during nasotracheal intubation to facilitate the procedure and reduce the rate of complications...
February 2, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29391101/comparative-analysis-of-laparoscopic-and-open-approaches-in-emergency-abdominal-surgery
#17
COMPARATIVE STUDY
Anaar Siletz, Jonathan Grotts, Catherine Lewis, Areti Tillou, Henry Magill Cryer, Ali Cheaito
The objective of this study was to evaluate usage and outcomes of emergency laparoscopic versus open surgery at a single tertiary academic center. Over a three-year period 165 patients were identified retrospectively using National Surgical Quality Improvement Program results. Appendectomies and cholecystectomies were excluded. Open and laparoscopic approaches were compared regarding preoperative and operative characteristics, the development of postoperative complications, 30-day mortality, and length of hospital stay...
October 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29357448/propagation-of-beta-gamma-rhythms-in-the-cortico-basal-ganglia-circuits-of-the-parkinsonian-rat
#18
Timothy Owen West, Luc Berthouze, David M Halliday, Vladimir Litvak, Andrew Sharott, Peter J Magill, Simon F Farmer
Much of the motor impairment associated with Parkinson's disease is thought to arise from pathological activity in the networks formed by the basal ganglia (BG) and motor cortex. To evaluate several hypotheses proposed to explain the emergence of pathological oscillations in Parkinsonism, we investigated changes to the directed connectivity in BG networks following dopamine depletion. We recorded local field potentials (LFPs) in the cortex and basal ganglia of rats rendered Parkinsonian by injection of 6-hydroxydopamine (6-OHDA) and in dopamine-intact controls...
January 10, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29356286/medical-equipment-deployment-in-pediatric-emergency-prehospital-medical-units-in-japan
#19
Noriyuki Kaku, Masahiko Nitta, Takashi Muguruma, Yuichiro Hirata, Kohei Tsukahara, Emily Knaup, Nobuyuki Nosaka, Yuki Enomoto
The deployment status of pediatric emergency equipment in ambulances in Japan is unknown. To investigate the status of and issues associated with prehospital emergency medical care for pediatric patients, we conducted a descriptive epidemiological study. We carried out a Web-based survey of 767 fire defense headquarters in Japan, of which 671 responded (valid response rate, 88%). Most of the fire defense headquarters equipped all of their ambulances with oxygen masks (82%), bag-valve masks (for neonates, 83%; for children, 84%), straight laryngoscope blades (for neonates, 47%; for children 68%), blood pressure cuffs for children (91%), oximeter probes (78%), and stiff neck collars (91%); but despite the need for other equipment such as nasopharyngeal and oropharyngeal airways, and Magill forceps, they were insufficiently deployed...
January 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29288190/can-we-s-ave-the-rectum-by-watchful-waiting-or-t-rans-a-nal-microsurgery-following-chemo-r-adiotherapy-versus-t-otal-mesorectal-excision-for-early-re-ctal-c-ancer-star-trec-study-protocol-for-a-multicentre-randomised-feasibility-study
#20
Anouk J M Rombouts, Issam Al-Najami, Natalie L Abbott, Ane Appelt, Gunnar Baatrup, Simon Bach, Aneel Bhangu, Karen-Lise Garm Spindler, Richard Gray, Kelly Handley, Manjinder Kaur, Ellen Kerkhof, Camilla Jensenius Kronborg, Laura Magill, Corrie A M Marijnen, Iris D Nagtegaal, Lars Nyvang, Femke P Peters, Per Pfeiffer, Cornelis Punt, Philip Quirke, David Sebag-Montefiore, Mark Teo, Nick West, Johannes H W de Wilt
INTRODUCTION: Total mesorectal excision (TME) is the highly effective standard treatment for rectal cancer but is associated with significant morbidity and may be overtreatment for low-risk cancers. This study is designed to determine the feasibility of international recruitment in a study comparing organ-saving approaches versus standard TME surgery. METHODS AND ANALYSIS: STAR-TREC trial is a multicentre international randomised, three-arm parallel, phase II feasibility study in patients with biopsy-proven adenocarcinoma of the rectum...
December 28, 2017: BMJ Open
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