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https://www.readbyqxmd.com/read/29770748/the-effect-of-switching-protease-inhibitors-to-raltegravir-on-endothelial-function-in-hiv-infected-patients
#1
Maaike Krikke, Kiki Tesselaar, Guido E L van den Berk, Sigrid A Otto, Laura H Freriks, Steven F L van Lelyveld, Frank J L Visseren, Andy I M Hoepelman, Joop E Arends
Objective Lipid management is one of the cornerstones of cardiovascular risk reduction. Treatment of HIV infection with protease inhibitors (PIs) may cause dyslipidaemia, whilst the integrase inhibitor raltegravir (RAL) has a relatively favorable effect on plasma lipids. We examined the effect of switching from PIs to RAL on endothelial function, and its effect on immunological and inflammatory parameters. Methods We performed a 16-week open-label prospective crossover study: 8 weeks intervention (switch PIs to RAL) and 8 weeks control (unchanged cART regimen)...
April 2018: HIV Clinical Trials
https://www.readbyqxmd.com/read/29768539/evaluation-of-prophylactic-and-therapeutic-effects-of-sildenafil-on-acute-radiation-proctitis-in-rats
#2
Erkan Yavuz, Gulcin Ercan, Onur Olgac Karagulle, Busra Yaprak Bayrak, Aytac Biricik, Candas Ercetin, Berk Gokcek, Hakan Yigitbas, Ramazan Kusaslan, Atilla Celik, Osman Bilgin Gulcicek
PURPOSE: To investigate the prophylactic and therapeutical effects of sildenafil in a model of acute radiation proctitis (ARP). METHODS: All experimental procedures of this study was examined by histopathological, immunohistochemical and transmission electron microscopic analysis. RESULTS: Our histopathological evaluations indicated significant increases in lesion severity, cryptic apsis, cryptitis, cryptic distortion, reactive atypia and infiltration depth of the control (proctitis) group...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29767296/evaluating-the-antimicrobial-apoptotic-and-cancer-cell-gene-delivery-properties-of-protein-capped-gold-nanoparticles-synthesized-from-the-edible-mycorrhizal-fungus-tricholoma-crassum
#3
Arpita Basu, Sarmishtha Ray, Supriyo Chowdhury, Arnab Sarkar, Deba Prasad Mandal, Shamee Bhattacharjee, Surekha Kundu
Biosynthesis of gold nanoparticles of distinct geometric shapes with highly functional protein coats without additional capping steps is rarely reported. This study describes green synthesis of protein-coated gold nanoparticles for the first time from the edible, mycorrhizal fungus Tricholoma crassum (Berk.) Sacc. The nanoparticles were of the size range 5-25 nm and of different shapes. Spectroscopic analysis showed red shift of the absorption maxima with longer reaction period during production and blue shift with increase in pH...
May 16, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29760524/what-does-dopamine-mean
#4
REVIEW
Joshua D Berke
Dopamine is a critical modulator of both learning and motivation. This presents a problem: how can target cells know whether increased dopamine is a signal to learn or to move? It is often presumed that motivation involves slow ('tonic') dopamine changes, while fast ('phasic') dopamine fluctuations convey reward prediction errors for learning. Yet recent studies have shown that dopamine conveys motivational value and promotes movement even on subsecond timescales. Here I describe an alternative account of how dopamine regulates ongoing behavior...
May 14, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29759974/the-ceramide-transporter-cert-is-involved-in-muscle-insulin-signaling-defects-under-lipotoxic-conditions
#5
Cécile L Bandet, Rana Mahfouz, Julien Véret, Athanassia Sotiropoulos, Maxime Poirier, Paola Giussani, Mélanie Campana, Erwann Philippe, Agnieszka Blachnio-Zabielska, Raphaëlle Ballaire, Xavier Le Liepvre, Olivier Bourron, Dušan Berkeš, Jan Górski, Pascal Ferré, Hervé Le Stunff, Fabienne Foufelle, Eric Hajduch
One main mechanism of insulin resistance (IR), a key feature of type-2 diabetes, is the accumulation of saturated fatty acids (FA) in muscles of obese and type-2 diabetic patients. Understanding the mechanism underlying lipid-induced IR is therefore a crucial challenge. Saturated FA are metabolized into lipid-derivatives called ceramides and their accumulation plays a central role in the development of muscle IR. Ceramides are produced in the endoplasmic reticulum (ER) and transported to the Golgi through a transporter called CERT, where they are converted into different sphingolipid species...
May 14, 2018: Diabetes
https://www.readbyqxmd.com/read/29759891/the-putative-role-of-oxidative-stress-and-inflammation-in-the-pathophysiology-of-sleep-dysfunction-across-neuropsychiatric-disorders-focus-on-chronic-fatigue-syndrome-bipolar-disorder-and-multiple-sclerosis
#6
REVIEW
Gerwyn Morris, Brendon Stubbs, Cristiano A Köhler, Ken Walder, Anastasiya Slyepchenko, Michael Berk, André F Carvalho
Sleep and circadian abnormalities are prevalent and burdensome manifestations of diverse neuro-immune diseases, and may aggravate the course of several neuropsychiatric disorders. The underlying pathophysiology of sleep abnormalities across neuropsychiatric disorders remains unclear, and may involve the inter-play of several clinical variables and mechanistic pathways. In this review, we propose a heuristic framework in which reciprocal interactions of immune, oxidative and nitrosative stress, and mitochondrial pathways may drive sleep abnormalities across potentially neuroprogressive disorders...
April 4, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29740795/coping-with-adversity-individual-differences-in-the-perception-of-noisy-and-accented-speech
#7
Drew J McLaughlin, Melissa M Baese-Berk, Tessa Bent, Stephanie A Borrie, Kristin J Van Engen
During speech communication, both environmental noise and nonnative accents can create adverse conditions for the listener. Individuals recruit additional cognitive, linguistic, and/or perceptual resources when faced with such challenges. Furthermore, listeners vary in their ability to understand speech in adverse conditions. In the present study, we compared individuals' receptive vocabulary, inhibition, rhythm perception, and working memory with transcription accuracy (i.e., intelligibility scores) for four adverse listening conditions: native speech in speech-shaped noise, native speech with a single-talker masker, nonnative-accented speech in quiet, and nonnative-accented speech in speech-shaped noise...
May 8, 2018: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29737634/-is-early-intervention-in-bipolar-disorder-what-it-claims-to-be-malhi-et-al
#8
Patrick D McGorry, Aswin Ratheesh, Michael Berk, Philippe Conus
No abstract text is available yet for this article.
May 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29736794/quality-readability-and-understandability-of-german-booklets-addressing-melanoma-patients
#9
Julia Brütting, Lydia Reinhardt, Maike Bergmann, Dirk Schadendorf, Christiane Weber, Wolfgang Tilgen, Carola Berking, Friedegund Meier
Booklets are the preferably used form among patient education materials and are often handed out during medical consultations in dermatological oncology settings. However, little is known about how beneficial they are and whether they correspond to essential quality characteristics. To assess the quality, readability, and understandability of currently freely available booklets written in German addressing melanoma patients (MP). Melanoma booklets in accordance with predefined criteria were searched and analyzed...
May 7, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29721165/precision-cancer-therapy-profiting-from-tumor-specific-defects-in-the-dna-damage-tolerance-system
#10
Olimpia Alessandra Buoninfante, Bas Pilzecker, Muhammad Assad Aslam, Ioannis Zavrakidis, Rianne van der Wiel, Marieke van de Ven, Paul C M van den Berk, Heinz Jacobs
DNA damage tolerance (DDT) enables replication to continue in the presence of a damaged template and constitutes a key step in DNA interstrand crosslink repair. In this way DDT minimizes replication stress inflicted by a wide range of endogenous and exogenous agents, and provides a critical first line defense against alkylating and platinating chemotherapeutics. Effective DDT strongly depends on damage-induced, site-specific PCNA-ubiquitination at Lysine (K) 164 by the E2/E3 complex (RAD6/18). A survey of The Cancer Genome Atlas (TCGA) revealed a high frequency of tumors presents RAD6/RAD18 bi-allelic inactivating deletions...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29714439/comparison-of-the-effects-of-diclofenac-potassium-and-tenoxicam-on-postoperative-pain-swelling-and-trismus-following-third-molar-surgery
#11
Ahmet Taylan Çebi, Metin Berk Kasapoğlu, Selin Eren, Çetin Kasapoğlu
Background/aim: This study aimed to compare two nonsteroidal antiinflammatory agents in relation to pain, swelling, and trismus following impacted third molar surgery. Materials and methods: The study was a randomized and a double-blinded study and included 50 healthy individuals. After the operation, patients were randomly assigned to 2 groups in which diclofenac potassium and tenoxicam were used. Impacted third molars were surgically extracted with local anesthesia. Pain was assessed postoperatively by visual analog scale at the 2nd, 6th, 8th, 12th, 24th, and 48th hours and on the 3rd, 5th, and 7th days...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29710239/preoperative-photographing-and-morphing-for-predictable-profiles-in-rhinoplasty-precision-profileplasty
#12
Fazil Apaydin, Berke Özücer
No abstract text is available yet for this article.
April 26, 2018: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29707408/a-de-novo-xp11-23-duplication-in-a-girl-with-a-severe-phenotype-expanding-the-clinical-spectrum
#13
Pinar Arican, Dilek Cavusoglu, Pinar Gencpinar, Berk Ozyilmaz, Taha Resid Ozdemir, Nihal Olgac Dundar
The Xp11.22-p11.23 duplication syndrome was described in 2009 by Giorda et al and is characterized by intellectual disability, speech delay, and electroencephalography anomalies. We report a case of a 23-month-old girl who presented with epilepsy and global developmental delay and who had a small duplication at Xp11.23. The case we present here is the first case showing the clinical features of Xp11.22-p11.23 duplication syndrome only involving synovial sarcoma, X breakpoint ( SSX ) genes: SSX1 , SSX3 , SSX4 , and SSX9 ...
June 2018: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/29705945/could-alzheimer-s-disease-originate-in-the-periphery-and-if-so-how-so
#14
REVIEW
Gerwyn Morris, Michael Berk, Michael Maes, Basant K Puri
The classical amyloid cascade model for Alzheimer's disease (AD) has been challenged by several findings. Here, an alternative molecular neurobiological model is proposed. It is shown that the presence of the APOE ε4 allele, altered miRNA expression and epigenetic dysregulation in the promoter region and exon 1 of TREM2, as well as ANK1 hypermethylation and altered levels of histone post-translational methylation leading to increased transcription of TNFA, could variously explain increased levels of peripheral and central inflammation found in AD...
April 29, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29698016/association-between-posttraumatic-stress-disorder-and-lack-of-exercise-poor-diet-obesity-and-co-occuring-smoking-a-systematic-review-and-meta-analysis
#15
Carissa van den Berk-Clark, Scott Secrest, Jesse Walls, Ellen Hallberg, Patrick J Lustman, F David Schneider, Jeffrey F Scherrer
OBJECTIVES: Research has shown that posttraumatic stress disorder (PTSD) increases the risk of development of cardiometabolic disease (CMD) including cardiovascular disease and diabetes. Whether PTSD is also associated with behavioral risk factors (e.g., diet, exercise, smoking and obesity) for CMD, is less clear. METHODS: PubMed, Web of Science, and Scopus databases were searched to obtain papers published between 1980-2016. Studies were reviewed for quality using the Quality of Cohort screen...
May 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29685870/effectiveness-of-an-internet-and-app-based-intervention-for-college-students-with-elevated-stress-randomized-controlled-trial
#16
Mathias Harrer, Sophia Helen Adam, Rebecca Jessica Fleischmann, Harald Baumeister, Randy Auerbach, Ronny Bruffaerts, Pim Cuijpers, Ronald C Kessler, Matthias Berking, Dirk Lehr, David Daniel Ebert
BACKGROUND: Mental health problems are highly prevalent among college students. Most students with poor mental health, however, do not receive professional help. Internet-based self-help formats may increase the utilization of treatment. OBJECTIVE: The aim of this randomized controlled trial was to evaluate the efficacy of an internet-based, app-supported stress management intervention for college students. METHODS: College students (n=150) with elevated levels of stress (Perceived Stress Scale 4-item version, PSS-4 ≥8) were randomly assigned to either an internet- and mobile-based stress intervention group with feedback on demand or a waitlist control group...
April 23, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29683081/self-blame-and-ptsd-following-sexual-assault-a-longitudinal-analysis
#17
Nora K Kline, Danielle S Berke, Charla A Rhodes, Maria M Steenkamp, Brett T Litz
Sexual assault is a prevalent trauma associated with high rates of posttraumatic stress disorder (PTSD). Social,cognitive theories posit that behavioral self-blame (i.e., attributing the cause of the assault to personal peri-event behavior) contributes to the etiology and maintenance of PTSD symptoms. Yet the direction of the association between self-blame and PTSD symptoms in the acute aftermath of sexual assault is unknown. This study evaluated temporal pathways between behavioral self-blame and PTSD symptom severity in an epidemiological sample of sexual assault survivors ( n = 126) assessed at four time points in the months immediately following the assault...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29673093/mechanisms-of-change-in-the-relationship-between-self-compassion-emotion-regulation-and-mental-health-a-systematic-review
#18
REVIEW
Elisa Inwood, Madeleine Ferrari
BACKGROUND: Research suggests that self-compassion may improve mental health by promoting emotion regulation (Berking & Whitley, ). This review aimed to identify studies which investigated the relationship between self-compassion, emotion regulation, and mental health in order to examine the role of emotional regulation as a mechanism of change. METHODS: Searches were conducted in PsycINFO, CINAHL, Medline complete, Web of Science and Scopus databases. Inclusion criteria required publications to be: peer reviewed, published in English, contain validated measures of self-compassion and emotion regulation, and report a direct analysis on the relationship between these constructs...
April 19, 2018: Applied Psychology. Health and Well-being
https://www.readbyqxmd.com/read/29661470/special-issue-on-simulation-of-traffic-safety-in-the-era-of-advances-in-technologies
#19
EDITORIAL
Constantinos Antoniou, Hilmi Berk Celikoglu, Haneen Farah, Carlos Lima Azevedo
No abstract text is available yet for this article.
April 13, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29656032/bioenergetics-and-synaptic-plasticity-as-potential-targets-for-individualizing-treatment-for-depression
#20
REVIEW
J Blair Price, Carrie Bronars, Sophie Erhardt, Kathyrn R Cullen, Lilly Schwieler, Michael Berk, Ken Walder, Sean L McGee, Mark A Frye, Susannah J Tye
Disruptions of bioenergetic signaling and neurogenesis are hallmarks of depression physiology and are often the product of dysregulation of the inflammatory, stress-response, and metabolic systems. These systems are extensively interrelated at the physiological level, yet the bulk of the literature to date addresses pathophysiological mechanisms in isolation. A more integrated understanding of the etiology, progression, and treatment response profiles of depression is possible through wider consideration of relevant preclinical and clinical studies that examine the result of disruptions in these systems...
April 12, 2018: Neuroscience and Biobehavioral Reviews
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