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https://www.readbyqxmd.com/read/28531772/diet-induced-weight-loss-and-markers-of-endothelial-dysfunction-and-inflammation-in-treated-patients-with-type-2-diabetes
#1
K A Berk, T P Oudshoorn, A J M Verhoeven, M T Mulder, A J M Roks, W A Dik, R Timman, E J G Sijbrands
BACKGROUND & AIMS: Overweight and obesity increase cardiovascular mortality in patients with type 2 diabetes (T2D). In a recent trial, however, diet-induced weight loss did not reduce the cardiovascular risk of patients with T2D, possibly due to the parallel intensive medical treatment. We investigated the effect of diet-induced weight loss on cardiovascular risk factors in overweight and obese patients with T2D, and whether this effect was influenced by the use of statins, ACE inhibitors, metformin and duration of T2D...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28523038/a-comparison-of-preoperative-and-postoperative-testicular-volume-and-blood-flow-in-patients-with-inguinal-hernia-hydrocele-and-cord-cyst-a-prospective-cohort-study
#2
Ahmet Ali Tuncer, Tamer Peker, Mehtap Berke Acar, Didem Baskin Embleton, Salih Cetinkursun
OBJECTIVE: To evaluate the effect of inguinal operations performed with a modified Ferguson technique upon testicular volume and blood flow. METHODS: This study involved 23 children receiving surgery for inguinal hernia, hydrocele, and cord cyst. This was a prospective study performed between April 2016 and June 2016 in a medical faculty pediatric surgery unit. The color Doppler ultrasound (CDUS) was used to assess testicular volume and blood flow before and after a modified Ferguson technique surgery...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28516431/a-comparison-of-neuroimaging-abnormalities-in-multiple-sclerosis-major-depression-and-chronic-fatigue-syndrome-myalgic-encephalomyelitis-is-there-a-common-cause
#3
REVIEW
Gerwyn Morris, Michael Berk, Basant K Puri
There is copious evidence of abnormalities in resting-state functional network connectivity states, grey and white matter pathology and impaired cerebral perfusion in patients afforded a diagnosis of multiple sclerosis, major depression or chronic fatigue syndrome (CFS) (myalgic encephalomyelitis). Systemic inflammation may well be a major element explaining such findings. Inter-patient and inter-illness variations in neuroimaging findings may arise at least in part from regional genetic, epigenetic and environmental variations in the functions of microglia and astrocytes...
May 17, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28515549/evaluation-of-modified-patient-health-questionnaire-9-teen-in-south-african-adolescents
#4
Shilpa Aggarwal, Lian Taljard, Zane Wilson, Michael Berk
BACKGROUND: This report describes the findings of the survey conducted by South African Depression and Anxiety Group (SADAG) in a cohort of disadvantaged South African adolescent scholars in which PHQ-9 teen version was modified and adapted (PHQ-9M) to improve the response rate. METHOD: PHQ-9M was administered to 2025 secondary students of 35 schools over 2 years in Gauteng Province, South Africa. RESULTS: The mean age was 15.8 years. 23% of respondents scored 9 or above, 26...
March 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28509918/generation-and-manipulation-of-hydrogel-microcapsules-by-droplet-based-microfluidics-for-mammalian-cell-culture
#5
REVIEW
Haishui Huang, Yin Yu, Yong Hu, Xiaoming He, O Berk Usta, Martin L Yarmush
Hydrogel microcapsules provide miniaturized and biocompatible niches for three-dimensional (3D) in vitro cell culture. They can be easily generated by droplet-based microfluidics with tunable size, morphology, and biochemical properties. Therefore, microfluidic generation and manipulation of cell-laden microcapsules can be used for 3D cell culture to mimic the in vivo environment towards applications in tissue engineering and high throughput drug screening. In this review of recent advances mainly since 2010, we will first introduce general characteristics of droplet-based microfluidic devices for cell encapsulation with an emphasis on the fluid dynamics of droplet breakup and internal mixing as they directly influence microcapsule's size and structure...
May 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28504318/antifungal-prophylaxis-in-newly-diagnosed-aml-patients-adherence-to-guidelines-and-feasibility-in-a-real-life-setting
#6
Sophie Berking, Daphne Doedens, Heidi Horns, Michael Fiegl, Helmut Ostermann, Christina T Rieger
Antifungal posaconazole prophylaxis for AML patients receiving induction chemotherapy has been routine at our centre since 2009. This retrospective study examined the feasibility and practicability of our prophylaxis guidelines in clinical practice. Data sets of 90 patients undergoing induction-chemotherapy for AML between 2011 and 2014 were evaluated regarding adherence to local guidelines for the administration of antifungal prophylaxis with posaconazole. 75.5% of the 90 patients received posaconazole prophylaxis...
May 15, 2017: Mycoses
https://www.readbyqxmd.com/read/28495471/quantitative-outcome-measures-for-systemic-sclerosis-related-microangiopathy-reliability-of-image-acquisition-in-nailfold-capillaroscopy
#7
Graham Dinsdale, Tonia Moore, Neil O'Leary, Michael Berks, Christopher Roberts, Joanne Manning, John Allen, Marina Anderson, Maurizio Cutolo, Roger Hesselstrand, Kevin Howell, Carmen Pizzorni, Vanessa Smith, Alberto Sulli, Marie Wildt, Christopher Taylor, Andrea Murray, Ariane L Herrick
BACKGROUND: Nailfold capillaroscopic parameters hold increasing promise as outcome measures for clinical trials in systemic sclerosis (SSc). Their inclusion as outcomes would often naturally require capillaroscopy images to be captured at several time points during any one study. Our objective was to assess repeatability of image acquisition (which has been little studied), as well as of measurement. METHOD: 41 patients (26 with SSc, 15 with primary Raynaud's phenomenon) and 10 healthy controls returned for repeat high-magnification (300×) videocapillaroscopy mosaic imaging of 10 digits one week after initial imaging (as part of a larger study of reliability)...
May 8, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28493380/post-synthesis-amine-borane-functionalization-of-metal-organic-framework-and-its-unusual-chemical-hydrogen-release-phenomenon
#8
Heinz Berke, Smair Barman, Arndt Remhof, Ralph Koitz, Marcella Iannuzzi, Olivier Blacque, Yigang Yan, Thomas Fox, Jürg Hutter, Andreas Züttel
We report a novel strategy for post-synthesis amine borane functionalization of MOFs under gas-solid phase transformation utilizing gaseous diborane. The covalently confined amine borane derivative decorated on the framework backbone is stable when preserved at low temperature, but spontaneously liberates soft chemical hydrogen at room temperature leading to the development of an unusual borenium type species (-NH=BH2+) ion-paired with hydroborate anion. Furthermore, the unsaturated amino borane (-NH=BH2) and the -iminodiborane ((--NHB2H5) were detected as final products...
May 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28493194/effectiveness-of-quercetin-in-an-experimental-rat-model-of-allergic-rhinitis
#9
Mustafa Sagit, Halil Polat, Seren Gulsen Gurgen, Elife Berk, Sabri Guler, Mehmet Yasar
We aimed to investigate whether quercetin had a therapeutic effect in an experimental rat model of allergic rhinitis. The study was conducted with 35 rats, which were randomly assigned into 4 groups: group 1 (n = 5), sham group; group 2 (quercetin group, n = 10) received 80 mg/kg day quercetin; group 3 (steroid group, n = 10) received steroid (mometasone furoate); and group 4 (control group, n = 10), received ovalbumin alone. Rats were sensitized by administration of ovalbumin on alternate days over 14 days via an intraperitoneal route...
May 10, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28481878/the-ap-1-transcription-factor-fosl1-causes-melanocyte-reprogramming-and-transformation
#10
K Maurus, A Hufnagel, F Geiger, S Graf, C Berking, A Heinemann, A Paschen, S Kneitz, C Stigloher, E Geissinger, C Otto, A Bosserhoff, M Schartl, S Meierjohann
The MAPK pathway is activated in the majority of melanomas and is the target of therapeutic approaches. Under normal conditions, it initiates the so-called immediate early response, which encompasses the transient transcription of several genes belonging to the AP-1 transcription factor family. Under pathological conditions, such as continuous MAPK pathway overactivation due to oncogenic alterations occurring in melanoma, these genes are constitutively expressed. The consequences of a permanent expression of these genes are largely unknown...
May 8, 2017: Oncogene
https://www.readbyqxmd.com/read/28480484/online-ethics-where-will-the-interface-of-mental-health-and-the-internet-lead-us
#11
REVIEW
Victoria Cosgrove, Emma Gliddon, Lesley Berk, David Grimm, Sue Lauder, Seetal Dodd, Michael Berk, Trisha Suppes
While e-health initiatives are poised to revolutionize delivery and access to mental health care, conducting clinical research online involves specific contextual and ethical considerations. Face-to-face psychosocial interventions can at times entail risk and have adverse psychoactive effects, something true for online mental health programs too. Risks associated with and specific to internet psychosocial interventions include potential breaches of confidentiality related to online communications (such as unencrypted email), data privacy and security, risks of self-selection and self-diagnosis as well as the shortcomings of receiving psychoeducation and treatment at distance from an impersonal website...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28478726/pattern-of-psychotropic-medication-use-over-two-decades-in-australian-women
#12
Amanda L Stuart, Mohammadreza Mohebbi, Julie A Pasco, Shae E Quirk, Sharon L Brennan-Olsen, Michael Berk, Lana J Williams
OBJECTIVE: Few population-based studies have been used to investigate secular trends in psychotropic medication use. Therefore, the aim of this study was to examine psychotropic medication use over time using data from the Geelong Osteoporosis Study, an on-going, population-based, cohort study of Australian women. METHODS: Of the 1494 women recruited at Time 1 (1993-1997), self-reported medication use from Time 2 (2004-2008) and/or Time 3 (2011-2014) was available for 889 women...
May 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28470927/systematic-assessment-of-environmental-risk-factors-for-bipolar-disorder-an-umbrella-review-of-systematic-reviews-and-meta-analyses
#13
REVIEW
Beatrice Bortolato, Cristiano A Köhler, Evangelos Evangelou, Jordi León-Caballero, Marco Solmi, Brendon Stubbs, Lazaros Belbasis, Isabella Pacchiarotti, Lars V Kessing, Michael Berk, Eduard Vieta, André F Carvalho
OBJECTIVES: The pathophysiology of bipolar disorder is likely to involve both genetic and environmental risk factors. In our study, we aimed to perform a systematic search of environmental risk factors for BD. In addition, we assessed possible hints of bias in this literature, and identified risk factors supported by high epidemiological credibility. METHODS: We searched the Pubmed/MEDLINE, EMBASE and PsycInfo databases up to 7 October 2016 to identify systematic reviews and meta-analyses of observational studies that assessed associations between putative environmental risk factors and BD...
May 3, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28470892/impact-of-irritability-a-2-year-observational-study-of-outpatients-with-bipolar-i-or-schizoaffective-disorder
#14
Lesley Berk, Karen T Hallam, Kamalesh Venugopal, Andrew James Lewis, David W Austin, Jayashri Kulkarni, Seetal Dodd, Anthony de Castella, Paul B Fitzgerald, Michael Berk
OBJECTIVES: Many people experience irritability when manic, hypomanic, or depressed, yet its impact on illness severity and quality of life in bipolar and schizoaffective disorders is poorly understood. This study aimed to examine the relationship between irritability and symptom burden, functioning, quality of life, social support, suicidality, and overall illness severity in a naturalistic cohort of people with bipolar I or schizoaffective disorder. METHODS: We used data from 239 adult outpatients with bipolar I or schizoaffective disorder in the Bipolar Comprehensive Outcomes Study (BCOS) - a non-interventional observational study with a 2-year follow-up period...
May 3, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28466751/book-review-neuroprogression-and-staging-in-bipolar-disorder-kapczinski-flavio-vieta-eduard-magalh%C3%A3-es-pedro-vs-berk-michael-eds-neuroprogression-and-staging-in-bipolar-disorder-new-york-ny-oxford-university-press-2015-isbn-9780198709992-alk-paper-368-pp-us
#15
https://www.readbyqxmd.com/read/28463235/perturbations-in-the-apoptotic-pathway-and-mitochondrial-network-dynamics-in-peripheral-blood-mononuclear-cells-from-bipolar-disorder-patients
#16
G Scaini, G R Fries, S S Valvassori, C P Zeni, G Zunta-Soares, M Berk, J C Soares, J Quevedo
Bipolar disorder (BD) is a severe psychiatric disorder characterized by phasic changes of mood and can be associated with progressive structural brain change and cognitive decline. The numbers and sizes of glia and neurons are reduced in several brain areas, suggesting the involvement of apoptosis in the pathophysiology of BD. Because the changes in mitochondrial dynamics are closely related with the early process of apoptosis and the specific processes of apoptosis and mitochondrial dynamics in BD have not been fully elucidated, we measured the apoptotic pathway and the expression of mitochondrial fission/fusion proteins from BD patients and healthy controls...
May 2, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28463161/feasibility-of-patient-reporting-of-symptomatic-adverse-events-via-the-patient-reported-outcomes-version-of-the-common-terminology-criteria-for-adverse-events-pro-ctcae-in-a-chemoradiotherapy-cooperative-group-multicenter-clinical-trial
#17
Ethan Basch, Stephanie L Pugh, Amylou C Dueck, Sandra A Mitchell, Lawrence Berk, Shannon Fogh, Lauren J Rogak, Marcha Gatewood, Bryce B Reeve, Tito R Mendoza, Ann M O'Mara, Andrea M Denicoff, Lori M Minasian, Antonia V Bennett, Ann Setser, Deborah Schrag, Kevin Roof, Joan K Moore, Thomas Gergel, Kevin Stephans, Andreas Rimner, Albert DeNittis, Deborah Watkins Bruner
PURPOSE: To assess the feasibility of measuring symptomatic adverse events (AEs) in a multicenter clinical trial using the National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). METHODS AND MATERIALS: Patients enrolled in NRG Oncology's RTOG 1012 (Prophylactic Manuka Honey for Reduction of Chemoradiation Induced Esophagitis-Related Pain during Treatment of Lung Cancer) were asked to self-report 53 PRO-CTCAE items representing 30 symptomatic AEs at 6 time points (baseline; weekly ×4 during treatment; 12 weeks after treatment)...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28460803/an-unexpected-presentation-of-sick-sinus-syndrome-isolated-ventricular-asystole
#18
Harun Gunes, Feruza Turan Sonmez, Halit Berk Canga, Ayhan Saritas
Sick sinus syndrome is a disorder of sinus node function characterized by various dysrhythmias such as sinus bradycardia or pause, paroxysmal regular or irregular atrial tachycardia, tachycardiabradycardia attacks or atrial fibrillation with slow ventricular response. Ventricular asystole with preserved atrial electrical activity is a rarely seen presenting rhythm in the ED and an extremely rare cause of syncope. A 67-year-old male having a syncope attack was admitted to the emergency department. His Glasgow coma scale score was 15 on admission...
April 27, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28459001/secondary-gis-built-environment-data-for-health-research-guidance-for-data-development
#19
Orion T Stewart, Heather A Carlos, Chanam Lee, Ethan M Berke, Philip M Hurvitz, Li Li, Anne Vernez Moudon, Mark P Doescher
Built environment (BE) data in geographic information system (GIS) format are increasingly available from public agencies and private providers. These data can provide objective, low-cost BE data over large regions and are often used in public health research and surveillance. Yet challenges exist in repurposing GIS data for health research. The GIS data do not always capture desired constructs; the data can be of varying quality and completeness; and the data definitions, structures, and spatial representations are often inconsistent across sources...
December 2016: Journal of Transport & Health
https://www.readbyqxmd.com/read/28450293/extracellular-cyclophilin-a-especially-acetylated-causes-pulmonary-hypertension-by-stimulating-endothelial-apoptosis-redox-stress-and-inflammation
#20
Chao Xue, Mark Sowden, Bradford C Berk
OBJECTIVE: Oxidative stress and inflammation play key roles in the development of pulmonary arterial hypertension (PAH). Cyclophilin A (CypA) is secreted in response to oxidative stress and promotes inflammation and cardiovascular disease. Endothelial cell (EC) dysfunction is an early event in the pathogenesis of PAH. We evaluated the role of extracellular CypA in PAH and compared the effects of acetylated CypA (AcK-CypA, increased by oxidative stress) and CypA on EC dysfunction. APPROACH AND RESULTS: In transgenic mice that express high levels of CypA in EC specifically, a PAH phenotype was observed at 3 months including increased right ventricular systolic pressure, α-smooth muscle actin expression in small arterioles, and CD45-positive cells in the lungs...
April 27, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
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