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https://www.readbyqxmd.com/read/29161237/bilateral-visual-field-defects-in-a-patient-treated-with-the-mek-and-braf-inhibitors-trametinib-and-dabrafenib-for-melanoma-of-unknown-origin
#1
Jakob Siedlecki, Marc Mackert, Armin Wolf, Carola Berking, Siegfried G Priglinger, Kirsten Eibl-Lindner
INTRODUCTION: Although the introduction of BRAF and MEK inhibitors has greatly enhanced treatment possibilities in advanced BRAFV600-mutated melanoma, class-related toxicities are rather frequent and often involve the eye. Ophthalmologic side effects most commonly include central/diffuse serous retinopathy and retinal vein occlusion. Affection of the optic nerve head however has not been described clinically. CASE REPORT: A 29-year-old man presented in our eye clinic with bilateral blurred vision...
April 17, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29158770/does-the-enterolactone-enl-affect-fatty-acid-transporters-and-lipid-metabolism-in-liver
#2
Krzysztof Drygalski, Klaudia Berk, Tomasz Charytoniuk, Nicoletta Iłowska, Bartłomiej Łukaszuk, Adrian Chabowski, Karolina Konstantynowicz-Nowicka
Background: NAFLD as a result of inappropriate diet and obesity, may progress to sever conditions such as: type 2 diabetes mellitus or steatohepatitis, and has recently become a prevalent topic of numerous investigations. Due to its dangerous aftermaths, finding new substances, such as polyphenols and their derivatives, which might reduce liver steatosis is the main target of research into NAFLD treatment. Hence, the aim of the present study was to evaluate the effect(s) of enterolactone (ENL), a metabolite of secoisolariciresinol (SECO), on lipid metabolism together with changes in the expression of fatty acid transporters in fatty liver...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29157373/risk-factors-affecting-length-of-stay-of-cats-in-an-animal-shelter-a-case-study-at-the-guelph-humane-society-2011-2016
#3
Natasha Janke, Olaf Berke, Tyler Flockhart, Shane Bateman, Jason B Coe
There is a strong need for animal shelters to determine strategies to decrease the incidence of healthy animals being euthanized due to a lack of space. Thus, the Capacity for Care program was implemented at the Guelph Humane Society during August 2014. One objective of the Capacity for Care program is to decrease length of stay of cats within the shelter to improve individual welfare and increase the number of successful adoptions. The current study uses data collected from the Guelph Humane Society between 2011 and 2016...
December 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29148618/interest-in-tanning-beds-and-sunscreen-in-german-speaking-countries
#4
Michael C Kirchberger, Laura F Kirchberger, Thomas K Eigentler, Raphael Reinhard, Carola Berking, Gerold Schuler, Lucie Heinzerling, Markus V Heppt
BACKGROUND: The growing incidence of nearly all types of skin cancer can be attributed to increased exposure to natural or artificial ultraviolet (UV) radiation. However, there is a scarcity of statistical data on risk behavior or sunscreen use, which would be important for any prevention efforts. METHODS: Using the search engine Google(®) , we analyzed search patterns for the terms Solarium (tanning bed), Sonnencreme (sunscreen), and Sonnenschutz (sun protection) in Germany, Austria, and Switzerland between 2004 and 2016, and compared it to search patterns worldwide...
November 17, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29144535/a-health-economic-outcome-evaluation-of-an-internet-based-mobile-supported-stress-management-intervention-for-employees
#5
David Daniel Ebert, Fanny Kählke, Claudia Buntrock, Matthias Berking, Filip Smit, Elena Heber, Harald Baumeister, Burkhardt Funk, Heleen Riper, Dirk Lehr
Objective This study aimed to estimate and evaluate the cost-effectiveness and cost-benefit of a guided internet- and mobile-supported occupational stress-management intervention (iSMI) for employees from the employer's perspective alongside a randomized controlled trial. Methods A sample of 264 employees with elevated symptoms of perceived stress (Perceived Stress Scale, PSS-10 ≥22) was randomly assigned either to the iSMI or a waitlist control (WLC) group with unrestricted access to treatment as usual. The iSMI consisted of seven sessions of problem-solving and emotion-regulation techniques and one booster session...
November 16, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29140996/childhood-tuberculosis-is-associated-with-decreased-abundance-of-t-cell-gene-transcripts-and-impaired-t-cell-function
#6
Cheryl Hemingway, Maurice Berk, Suzanne T Anderson, Victoria J Wright, Shea Hamilton, Hariklia Eleftherohorinou, Myrsini Kaforou, Greg M Goldgof, Katy Hickman, Beate Kampmann, Johan Schoeman, Brian Eley, David Beatty, Sandra Pienaar, Mark P Nicol, Michael J Griffiths, Simon J Waddell, Sandra M Newton, Lachlan J Coin, David A Relman, Giovanni Montana, Michael Levin
The WHO estimates around a million children contract tuberculosis (TB) annually with over 80 000 deaths from dissemination of infection outside of the lungs. The insidious onset and association with skin test anergy suggests failure of the immune system to both recognise and respond to infection. To understand the immune mechanisms, we studied genome-wide whole blood RNA expression in children with TB meningitis (TBM). Findings were validated in a second cohort of children with TBM and pulmonary TB (PTB), and functional T-cell responses studied in a third cohort of children with TBM, other extrapulmonary TB (EPTB) and PTB...
2017: PloS One
https://www.readbyqxmd.com/read/29138498/glutaredoxin-1-mediates-the-protective-effect-of-steady-laminar-flow-on-endothelial-cells-against-oxidative-stress-induced-apoptosis-via-inhibiting-bim
#7
Yao Li, Meng Ren, Xiaoqun Wang, Xingxing Cui, Hongmei Zhao, Chuanrong Zhao, Jing Zhou, Yanan Guo, Yi Hu, Chen Yan, Bradford Berk, Jing Wang
Endothelial cell apoptosis induced by oxidative stress is an early event in the development of atherosclerosis. Several antioxidant enzymes which can cope with oxidative stress are up-regulated by the anti-atherogenic laminar blood flow often seen in straight or unbranched regions of blood vessels. However, the molecular mechanism responsible for flow-induced beneficial effects is incompletely understood. Here we report the role of glutaredoxin 1 (Grx1), an antioxidant enzyme, in flow-mediated protective effect in endothelial cells...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29132808/bilateral-vocal-fold-medialization-a-treatment-for-abductor-spasmodic-dysphonia
#8
Karuna Dewan, Gerald S Berke
INTRODUCTION: Abductor spasmodic dysphonia, a difficult-to-treat laryngologic condition, is characterized by spasms causing the vocal folds to remain abducted despite efforts to adduct them during phonation. Traditional treatment for abductor spasmodic dysphonia-botulinum toxin injection into the posterior cricoarytenoid muscle-can be both technically challenging and uncomfortable. Due to the difficulty of needle placement, it is often unsuccessful. The purpose of this investigation is to present a previously undescribed treatment for abductor spasmodic dysphonia-bilateral vocal fold medialization...
November 10, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29132073/evaluation-of-a-text-message-based-maintenance-intervention-for-major-depressive-disorder-after-inpatient-cognitive-behavioral-therapy
#9
Sandra Schlicker, David D Ebert, Thomas Middendorf, Ingrid Titzler, Matthias Berking
INTRODUCTION: High relapse rates in Major Depressive Disorder (MDD) indicate the need for interventions enhancing the sustainability of treatment outcomes. Primary aim of the present study was to evaluate the effectiveness of a text-message-based maintenance intervention for depression (TMMI-D). Additionally, we aimed to clarify whether the use of individualized messages would lead to better outcome than the use of standardized messages which focused upon adaptive ways of regulating undesired emotions...
October 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29115652/early-laparoscopic-cholecystectomy-following-acute-biliary-pancreatitis-expedites-recovery
#10
Seracettin Eğin, Metin Yeşiltaş, Berk Gökçek, Hakan Tezer, Servet Rüştü Karahan
BACKGROUND: In this retrospective study, we aimed to assess the reliability of early cholecystectomy, risk of recurrent biliary pancreatitis, and their effects on hospital length of stay and morbidity by comparing the results of early and late laparoscopic cholecystectomy in patients with acute biliary pancreatitis. METHODS: A total of 131 patients, who were diagnosed with acute biliary pancreatitis at Okmeydanı Education and Research Hospital in January 2009-December 2012, were included in the study...
November 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29111963/endophytic-fungal-production-rates-of-volatile-organic-compounds-are-highest-under-microaerophilic-conditions
#11
Heidi R Schoen, Walter Berk Knighton, Brent M Peyton
Volatile organic compound (VOC) production from an endophytic fungus was quantified at four oxygen concentrations (0, 1, 13 and 21 %) throughout culture growth phases. The filamentous fungus, a Nodulisporium sp. (designated TI-13), was grown in a solid-state reactor with an agricultural byproduct, beet pulp, as the solid substrate. The VOCs, with potential applications as biofuels, natural flavour compounds and bioactive mixtures, were measured with a recently introduced platinum catalyst and proton transfer reaction mass spectrometry quantification system...
November 7, 2017: Microbiology
https://www.readbyqxmd.com/read/29108353/evaluation-of-real-world-treatment-outcomes-in-patients-with-distant-metastatic-merkel-cell-carcinoma-following-second-line-chemotherapy-in-europe
#12
Jürgen C Becker, Eva Lorenz, Selma Ugurel, Thomas K Eigentler, Felix Kiecker, Claudia Pföhler, Ivonne Kellner, Friedegund Meier, Katharina Kähler, Peter Mohr, Carola Berking, Gabriele Haas, Christoph Helwig, Dina Oksen, Dirk Schadendorf, Lisa Mahnke, Murtuza Bharmal
Background and aims: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer; few treatments exist for patients with advanced disease. Once tumors metastasize to distant sites, patients generally receive chemotherapy, but response duration and progression-free survival (PFS) are typically short. Few studies have assessed the efficacy of second-line chemotherapy for metastatic MCC. Here, we studied outcomes in patients who received ≥ 2 lines of chemotherapy for metastatic MCC. Materials and methods: Patients in an MCC-specific registry diagnosed with stage IV MCC between November 1, 2004, and September 15, 2015, and treated with second-line or later chemotherapy were analyzed retrospectively...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29105879/efficacy-of-a-web-based-intervention-with-and-without-guidance-for-employees-with-risky-drinking-results-of-a-three-arm-randomized-controlled-trial
#13
Leif Boß, Dirk Lehr, Michael Patrick Schaub, Raquel Paz Castro, Heleen Riper, Matthias Berking, David Daniel Ebert
AIMS: To test the efficacy of a web-based alcohol intervention with and without guidance. DESIGN: Three parallel groups with primary endpoint after 6 weeks. SETTING: Open recruitment in the German working population. PARTICIPANTS: Adults (178 males/ 256 females, mean age of 47) consuming at least 21/14 weekly standard units of alcohol (SUA) and scoring ≥8/6 on the Alcohol Use Disorders Identification Test. INTERVENTION: Five web-based modules including personalized normative feedback, motivational interviewing, goal setting, problem solving, and emotion regulation over 5 weeks...
November 4, 2017: Addiction
https://www.readbyqxmd.com/read/29103052/increasing-efficiency-of-recruitment-in-early-parkinson-s-disease-trials-a-case-study-examination-of-the-steady-pd-iii-trial
#14
Sarah Berk, Brittany L Greco, Kevin Biglan, Catherine M Kopil, Robert G Holloway, Claire Meunier, Tanya Simuni
BACKGROUND: Challenges in clinical trial recruitment threaten the successful development of improved therapies. This is particularly true in Parkinson's disease (PD) studies of disease modification where the population of interest is difficult to find and study design is more complex. OBJECTIVE: This paper seeks to understand how STEADY PD III, a National Institute of Neurological Disorders and Stroke (NINDS) funded phase 3 trial evaluating the efficacy of isradipine as a disease modifying agent for PD, was able to recruit their full target population 6 months ahead of schedule...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29101602/garcinia-mangostana-linn-displays-antidepressant-like-and-pro-cognitive-effects-in-a-genetic-animal-model-of-depression-a-bio-behavioral-study-in-the-flinders-sensitive-line-rat
#15
Inge Oberholzer, Marisa Möller, Brendan Holland, Olivia M Dean, Michael Berk, Brian H Harvey
There is abundant evidence for both disorganized redox balance and cognitive deficits in major depressive disorder (MDD). Garcinia mangostana Linn (GM) has anti-oxidant activity. We studied the antidepressant-like and pro-cognitive effects of raw GM rind in Flinders Sensitive Line (FSL) rats, a genetic model of depression, following acute and chronic treatment compared to a reference antidepressant, imipramine (IMI). The chemical composition of the GM extract was analysed for levels of α- and γ-mangostin...
November 3, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29100289/chemosensitivity-directed-therapy-compared-to-dacarbazine-in-chemo-naive-advanced-metastatic-melanoma-a-multicenter-randomized-phase-3-decog-trial
#16
Selma Ugurel, Carmen Loquai, Patrick Terheyden, Dirk Schadendorf, Erika Richtig, Jochen Utikal, Ralf Gutzmer, Knuth Rass, Cord Sunderkötter, Annette Stein, Michael Fluck, Martin Kaatz, Uwe Trefzer, Katharina Kähler, Rudolf Stadler, Carola Berking, Christoph Höller, Laura Kerschke, Lutz Edler, Annette Kopp-Schneider, Jürgen C Becker
Chemotherapy still plays an important role in metastatic melanoma, particularly for patients who are not suitable or have no access to highly efficacious new therapies. Pre-therapeutic chemosensitivity testing might be useful to identify optimal chemotherapy regimens for individual patients. This multicenter randomized phase-3 trial was aimed to test for superiority of chemosensitivity-directed combination chemotherapy compared to standard dacarbazine monochemotherapy, and to demonstrate the chemosensitivity test result as prognostic in metastatic melanoma...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29082439/the-role-of-depression-pharmacogenetic-decision-support-tools-in-shared-decision-making
#17
Katarina Arandjelovic, Harris A Eyre, Eric Lenze, Ajeet B Singh, Michael Berk, Chad Bousman
Patients discontinue antidepressant medications due to lack of knowledge, unrealistic expectations, and/or unacceptable side effects. Shared decision making (SDM) invites patients to play an active role in their treatment and may indirectly improve outcomes through enhanced engagement in care, adherence to treatment, and positive expectancy of medication outcomes. We believe decisional aids, such as pharmacogenetic decision support tools (PDSTs), facilitate SDM in the clinical setting. PDSTs may likewise predict drug tolerance and efficacy, and therefore adherence and effectiveness on an individual-patient level...
October 29, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29074662/complete-genome-sequences-of-cluster-a-mycobacteriophages-bobswaget-fred313-kady-lokk-myradee-stagni-and-stepmih
#18
Kristen A Butela, Susan M R Gurney, Heather L Hendrickson, Janine M LeBlanc-Straceski, Anastasia M Zimmerman, Stephanie B Conant, Nikki E Freed, Olin K Silander, Joshua J Thomson, Charlotte A Berkes, Cristina Bertolez, Courtney G Davies, Amber Elinsky, Alison J Hanlon, Juliette Nersesyan, Payal Patel, John Sherwood, Tiffany Tieu Ngo, Kathryn A Wisniewski, Kathrine Yacoo, Paul M Arendse, Nathan W Bowlen, Jasmina Cunmulaj, Julie L Downs, Charlee A Ferrenberg, Alexandra E Gassman, Cody E R Gilligan, Emily Gorkiewicz, Christopher Harness, Anthony Huffman, Christina Jones, Anna Julien, Alexis E Kupic, Sayonara F Latu, Thomas J Manning, Danielle Maxwell, Catherine E Meyer, Madeleine Reardon, Matthew Slaughter, Royce Swasey, Rebecca I Tennent, Victoria Torres, Tamia Waller, Rachel M Worcester, Brooke L Yost, Steven G Cresawn, Rebecca A Garlena, Deborah Jacobs-Sera, Welkin H Pope, Daniel A Russell, Graham F Hatfull, Jacob D Kagey
Seven mycobacteriophages from distinct geographical locations were isolated, using Mycobacterium smegmatis mc(2)155 as the host, and then purified and sequenced. All of the genomes are related to cluster A mycobacteriophages, BobSwaget and Lokk in subcluster A2; Fred313, KADY, Stagni, and StepMih in subcluster A3; and MyraDee in subcluster A18, the first phage to be assigned to that subcluster.
October 26, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29060857/needle-release-mechanism-enabling-multiple-insertions-with-an-ultrasound-guided-prostate-brachytherapy-robot
#19
Shuyang Chen, Berk Gonenc, Meng Li, Danny Y Song, Everette C Burdette, Iulian Iordachita, Peter Kazanzides
We present a robotic system for transrectal ultrasound-guided prostate brachytherapy that employs a quick release mechanism to enable multiple needles to be inserted into the prostate prior to plan optimization. The mechanism consists of two actuated fingers that act as needle guides, thereby allowing insertion of both parallel and angled needles. Path planning, including reordering of needles within a batch, is required to avoid collisions with previously inserted needles. We perform two phantom experiments using clinical implant plans...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29058512/maternal-serum-autotaxin-levels-in-early-and-late-onset-preeclampsia
#20
Hakan Erenel, Nevin Yilmaz, Tayfur Cift, Berk Bulut, Isik Sozen, Berna Aslan Cetin, Altay Gezer, Hakan Ekmekci, Baris Kaya, Abdullah Tuten
PURPOSE: We aimed to compare the serum autotaxin levels in early- and late- preeclamptic and healthy pregnant patients at a university hospital. METHODS: A total of 55 singleton preeclamptic women who delivered at Cerrahpasa Medical Faculty were included in the study. The patients were subdivided into two groups: early-onset preeclampsia (n = 31) and late-onset preeclampsia (n = 24). Demographic and clinical data were compared between early-onset and late-onset preeclamptic patients...
November 2017: Hypertension in Pregnancy
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