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https://www.readbyqxmd.com/read/29752909/systematic-review-of-caregiver-and-dyad-interventions-following-adult-traumatic-brain-injury
#1
REVIEW
Natalie Kreitzer, Brad G Kurowski, Tamilyn Bakas
OBJECTIVE: To describe and synthesize the existing literature of published adult TBI family caregiver and dyad intervention studies. Traumatic brain injuries (TBIs) are common and have a significant long-term impact, with some characterizing TBI as a chronic condition. Informal family caregivers of adults with TBI suffer from high rates of burnout, depression, fatigue, anxiety, lower subjective well-being, and poorer levels of physical health compared to non-caregivers. There is a critical gap in the understanding of interventions designed to address the impact of TBI on adult patients and their family caregivers...
May 9, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29748377/galectin-3-modulates-the-polarized-surface-delivery-of-%C3%AE-1-integrin-in-epithelial-cells
#2
Ellena Hönig, Karina Ringer, Jenny Dewes, Tobias von Mach, Natalia Kamm, Geri Kreitzer, Ralf Jacob
Epithelial cells require a precise intracellular transport and sorting machinery in order to establish and maintain their polarized architecture. This machinery includes beta-galactoside binding galectins for glycoprotein targeting to the apical membrane. Galectin-3 sorts cargo destined for the apical plasma membrane into vesicular carriers. After delivery of cargo to the apical milieu, galectin-3 recycles back into sorting organelles. We analyzed the role of galectin-3 in the polarized distribution of β1-integrin in MDCK cells...
May 10, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29613854/nuclear-receptor-modulation-by-kinesin
#3
A M P B Seneviratne, Geri Kreitzer
No abstract text is available yet for this article.
March 30, 2018: Aging
https://www.readbyqxmd.com/read/29466379/activation-of-retinal-glial-m%C3%A3-ller-cells-by-extracellular-atp-induces-pronounced-increases-in-extracellular-h-flux
#4
Boriana K Tchernookova, Chad Heer, Marin Young, David Swygart, Ryan Kaufman, Michael Gongwer, Lexi Shepherd, Hannah Caringal, Jason Jacoby, Matthew A Kreitzer, Robert Paul Malchow
Small alterations in extracellular acidity are potentially important modulators of neuronal signaling within the vertebrate retina. Here we report a novel extracellular acidification mechanism mediated by glial cells in the retina. Using self-referencing H+-selective microelectrodes to measure extracellular H+ fluxes, we show that activation of retinal Müller (glial) cells of the tiger salamander by micromolar concentrations of extracellular ATP induces a pronounced extracellular H+ flux independent of bicarbonate transport...
2018: PloS One
https://www.readbyqxmd.com/read/29425490/fast-spiking-interneurons-supply-feedforward-control-of-bursting-calcium-and-plasticity-for-efficient-learning
#5
Scott F Owen, Joshua D Berke, Anatol C Kreitzer
Fast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells implicated in two seemingly independent network functions: gain control and network plasticity. Little is known, however, about how these roles interact. Here, we use a combination of cell-type-specific ablation, optogenetics, electrophysiology, imaging, and behavior to describe a unified mechanism by which striatal FSIs control burst firing, calcium influx, and synaptic plasticity in neighboring medium spiny projection neurons (MSNs)...
February 8, 2018: Cell
https://www.readbyqxmd.com/read/29402499/editorial-overview-neurobiology-of-disease-2018
#6
EDITORIAL
Claudia Bagni, Anatol C Kreitzer
No abstract text is available yet for this article.
February 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29398356/a-subpopulation-of-striatal-neurons-mediates-levodopa-induced-dyskinesia
#7
Allison E Girasole, Matthew Y Lum, Diane Nathaniel, Chloe J Bair-Marshall, Casey J Guenthner, Liqun Luo, Anatol C Kreitzer, Alexandra B Nelson
Parkinson's disease is characterized by the progressive loss of midbrain dopamine neurons. Dopamine replacement therapy with levodopa alleviates parkinsonian motor symptoms but is complicated by the development of involuntary movements, termed levodopa-induced dyskinesia (LID). Aberrant activity in the striatum has been hypothesized to cause LID. Here, to establish a direct link between striatal activity and dyskinesia, we combine optogenetics and a method to manipulate dyskinesia-associated neurons, targeted recombination in active populations (TRAP)...
February 21, 2018: Neuron
https://www.readbyqxmd.com/read/29329250/blood-flow-and-continuous-eeg-changes-during-symptomatic-plateau-waves
#8
Natalie Kreitzer, Maggie Huynh, Brandon Foreman
Benign meningiomas uncommonly lead to significant cerebral edema, with only a few cases previously reported in the medical literature. The present study describes the case of a 49-year-old female who had a meningioma resection. She subsequently developed malignant cerebral edema and had episodes that were initially concerning for seizure activity. However, transient blood flow changes concerning for intracranial pressure (ICP) crises, were demonstrated on electroencephalogram (EEG) as well as noninvasive cerebral blood flow monitoring...
January 12, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29118210/illuminating-neural-circuits-from-molecules-to-mri
#9
REVIEW
Jin Hyung Lee, Anatol C Kreitzer, Annabelle C Singer, Nicholas D Schiff
Neurological disease drives symptoms through pathological changes to circuit functions. Therefore, understanding circuit mechanisms that drive behavioral dysfunction is of critical importance for quantitative diagnosis and systematic treatment of neurological disease. Here, we describe key technologies that enable measurement and manipulation of neural activity and neural circuits. Applying these approaches led to the discovery of circuit mechanisms underlying pathological motor behavior, arousal regulation, and protein accumulation...
November 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29079481/g-protein-g%C3%AE-13-functions-with-abl-kinase-to-regulate-actin-cytoskeletal-reorganization
#10
Limin Wang, Dawei Wang, Bowen Xing, Ying-Cai Tan, Jianyun Huang, Bingqian Liu, Viktoriya Syrovatkina, Cedric Espenel, Geri Kreitzer, Lin Guo, J Jillian Zhang, Xin-Yun Huang
Heterotrimeric G-proteins are essential cellular signal transducers. One of the G-proteins, Gα13 , is critical for actin cytoskeletal reorganization, cell migration, cell proliferation, and apoptosis. Previously, we have shown that Gα13 is essential for both G-protein-coupled receptor and receptor tyrosine kinase-induced actin cytoskeletal reorganization such as dynamic dorsal ruffle turnover and cell migration. However, the mechanism by which Gα13 signals to actin cytoskeletal reorganization is not completely understood...
December 8, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29064772/reducing-diabetes-distress-and-improving-self-management-with-mindfulness
#11
Robin R Whitebird, Mary Jo Kreitzer, Gabriela Vazquez-Benitez, Chris J Enstad
Stress associated with diabetes makes managing diabetes harder. We investigated whether mindfulness-based stress reduction (MBSR) could reduce diabetes distress and improve management. We recruited 38 participants to complete an MBSR program. Surveys and lab values were completed at baseline and post-intervention. Participants showed significant improvement in diabetes-related distress (Cohen's d -.71, p < .002), psychosocial self-efficacy (Cohen's d .80, p < .001), and glucose control (Cohen's d -...
January 2018: Social Work in Health Care
https://www.readbyqxmd.com/read/28899268/linking-the-unitary-paradigm-to-policy-through-a-synthesis-of-caring-science-and-integrative-nursing
#12
Mary S Koithan, Mary Jo Kreitzer, Jean Watson
The principles of integrative nursing and caring science align with the unitary paradigm in a way that can inform and shape nursing knowledge, patient care delivery across populations and settings, and new healthcare policy. The proposed policies may transform the healthcare system in a way that supports nursing praxis and honors the discipline's unitary paradigm. This call to action provides a distinct and hopeful vision of a healthcare system that is accessible, equitable, safe, patient-centered, and affordable...
July 2017: Nursing Science Quarterly
https://www.readbyqxmd.com/read/28881568/modulation-of-estrogen-related-receptor-alpha-activity-by-the-kinesin-kif17
#13
Am Pramodh Bandara Seneviratne, Zeynep Turan, Aurelie Hermant, Patrick Lecine, William O Smith, Jean-Paul Borg, Fanny Jaulin, Geri Kreitzer
Estrogen-related receptor alpha (ERR1) is an orphan nuclear receptor that can bind transcriptional co-activators constitutively. ERR1 expression correlates with poor patient outcomes in breast cancer, heightening interest in this nuclear receptor as a therapeutic target. Because ERR1 has no known regulatory ligand, a major challenge in targeting its activity is to find cellular or synthetic modulators of its function. We identified an interaction between ERR1 and KIF17, a kinesin-2 family microtubule motor, in a yeast-2-hybrid screen...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28855292/extracellular-h-fluxes-from-tiger-salamander-m%C3%A3-ller-glial-cells-measured-using-self-referencing-h-selective-microelectrodes
#14
Matthew A Kreitzer, David Swygart, Meredith Osborn, Blair Skinner, Chad Heer, Ryan Kaufman, Bethany Williams, Lexi Shepherd, Hannah Caringal, Michael Gongwer, Boriana K Tchernookova, Robert P Malchow
Self-referencing H+ -selective electrodes were used to measure extracellular H+ fluxes from Müller (glial) cells isolated from the tiger salamander retina. A novel chamber enabled stable recordings using H+ -selective microelectrodes in a self-referencing format using bicarbonate-based buffer solutions. A small basal H+ flux was observed from the end foot region of quiescent cells bathed in 24 mM bicarbonate-based solutions, and increasing extracellular potassium induced a dose-dependent increase in H+ flux...
December 1, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28804747/care-experiences-of-adults-with-a-dual-diagnosis-and-their-family-caregivers
#15
David B Nicholas, Avery Calhoun, Anne Marie McLaughlin, Janki Shankar, Linda Kreitzer, Masimba Uzande
Individuals diagnosed with developmental disability and mental illness (a "dual diagnosis") contend with multiple challenges and system-related barriers. Using an interpretive description approach, separate qualitative interviews were conducted with adults with a dual diagnosis (n = 7) and their caregiving parents (n = 8) to examine care-related experiences. Results indicate that individuals with a dual diagnosis and their families experience misunderstanding and stigma. Families provide informal complex care amid insufficient and uncoordinated services but are often excluded from formal care planning...
January 2017: Global Qualitative Nursing Research
https://www.readbyqxmd.com/read/28596477/modulation-of-estrogen-related-receptor-alpha-activity-by-the-kinesin-kif17
#16
A M P B Seneviratne, Zeynep Turan, Aurelie Hermant, Patrick Lecine, William O Smith, Jean-Paul Borg, Fanny Jaulin, Geri Kreitzer
Estrogen-related receptor alpha (ERR1) is an orphan nuclear receptor that can bind transcriptional co-activators constitutively. ERR1 expression correlates with poor patient outcomes in breast cancer, heightening interest in this nuclear receptor as a therapeutic target. Because ERR1 has no known regulatory ligand, a major challenge in targeting its activity is to find cellular or synthetic modulators of its function. We identified an interaction between ERR1 and KIF17, a kinesin-2 family microtubule motor, in a yeast-2-hybrid screen...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28595760/reflections-on-healing-from-a-nursing-perspective
#17
Mary Jo Kreitzer
No abstract text is available yet for this article.
July 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28536194/wild-tobacco-genomes-reveal-the-evolution-of-nicotine-biosynthesis
#18
Shuqing Xu, Thomas Brockmöller, Aura Navarro-Quezada, Heiner Kuhl, Klaus Gase, Zhihao Ling, Wenwu Zhou, Christoph Kreitzer, Mario Stanke, Haibao Tang, Eric Lyons, Priyanka Pandey, Shree P Pandey, Bernd Timmermann, Emmanuel Gaquerel, Ian T Baldwin
Nicotine, the signature alkaloid of Nicotiana species responsible for the addictive properties of human tobacco smoking, functions as a defensive neurotoxin against attacking herbivores. However, the evolution of the genetic features that contributed to the assembly of the nicotine biosynthetic pathway remains unknown. We sequenced and assembled genomes of two wild tobaccos, Nicotiana attenuata (2.5 Gb) and Nicotiana obtusifolia (1.5 Gb), two ecological models for investigating adaptive traits in nature. We show that after the Solanaceae whole-genome triplication event, a repertoire of rapidly expanding transposable elements (TEs) bloated these Nicotiana genomes, promoted expression divergences among duplicated genes, and contributed to the evolution of herbivory-induced signaling and defenses, including nicotine biosynthesis...
June 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28264820/microtubule-motors-in-establishment-of-epithelial-cell-polarity
#19
REVIEW
Geri Kreitzer, Monn Monn Myat
Epithelial cells play a key role in insuring physiological homeostasis by acting as a barrier between the outside environment and internal organs. They are also responsible for the vectorial transport of ions and fluid essential to the function of many organs. To accomplish these tasks, epithelial cells must generate an asymmetrically organized plasma membrane comprised of structurally and functionally distinct apical and basolateral membranes. Adherent and occluding junctions, respectively, anchor cells within a layer and prevent lateral diffusion of proteins in the outer leaflet of the plasma membrane and restrict passage of proteins and solutes through intercellular spaces...
February 1, 2018: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28242731/neural-circuitry-for-behavioural-arrest
#20
REVIEW
Thomas Roseberry, Anatol Kreitzer
The ability to stop ongoing movement is fundamental to animal survival. Behavioural arrest involves the hierarchical integration of information throughout the forebrain, which ultimately leads to the coordinated inhibition and activation of specific brainstem motor centres. Recent advances have shed light on multiple regions and pathways involved in this critical behavioural process. Here, we synthesize these new findings together with previous work to build a more complete understanding of the circuit mechanisms underlying suppression of ongoing action...
April 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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