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https://www.readbyqxmd.com/read/27387649/parkinsonism-driven-by-antipsychotics-originates-from-dopaminergic-control-of-striatal-cholinergic-interneurons
#1
Geetika Kharkwal, Karen Brami-Cherrier, José E Lizardi-Ortiz, Alexandra B Nelson, Maria Ramos, Daniel Del Barrio, David Sulzer, Anatol C Kreitzer, Emiliana Borrelli
Typical antipsychotics can cause disabling side effects. Specifically, antagonism of D2R signaling by the typical antipsychotic haloperidol induces parkinsonism in humans and catalepsy in rodents. Striatal dopamine D2 receptors (D2R) are major regulators of motor activity through their signaling on striatal projection neurons and interneurons. We show that D2R signaling on cholinergic interneurons contributes to an in vitro pause in firing of these otherwise tonically active neurons and to the striatal dopamine/acetylcholine balance...
July 6, 2016: Neuron
https://www.readbyqxmd.com/read/27373834/activation-of-direct-and-indirect-pathway-medium-spiny-neurons-drives-distinct-brain-wide-responses
#2
Hyun Joo Lee, Andrew J Weitz, David Bernal-Casas, Ben A Duffy, ManKin Choy, Alexxai V Kravitz, Anatol C Kreitzer, Jin Hyung Lee
A central theory of basal ganglia function is that striatal neurons expressing the D1 and D2 dopamine receptors exert opposing brain-wide influences. However, the causal influence of each population has never been measured at the whole-brain scale. Here, we selectively stimulated D1 or D2 receptor-expressing neurons while visualizing whole-brain activity with fMRI. Excitation of either inhibitory population evoked robust positive BOLD signals within striatum, while downstream regions exhibited significantly different and generally opposing responses consistent with-though not easily predicted from-contemporary models of basal ganglia function...
July 20, 2016: Neuron
https://www.readbyqxmd.com/read/27257307/adolescent-determinants-of-abortion-attitudes-evidence-from-the-children-of-the-national-longitudinal-survey-of-youth
#3
Julianna Pacheco, Rebecca Kreitzer
The stability of abortion opinions suggests that pre-adult factors influence these attitudes more than contemporaneous political events. Surprisingly, however, we know little about the origins of abortion opinions, no doubt because the majority of research focuses on cross-sectional analyses of patterns across cohorts. We use a developmental model that links familial and contextual factors during adolescence to abortion attitudes years later when respondents are between 21 and 38 years old. Findings show that religious adherence and maternal gender role values are significant predictors of adult abortion opinions, even after controlling for contemporaneous religious adherence and the respondents' own views on gender roles...
2016: Public Opinion Quarterly
https://www.readbyqxmd.com/read/26937316/complementary-and-alternative-medicine-use-in-the-us-adult-low-back-pain-population
#4
Neha Ghildayal, Pamela Jo Johnson, Roni L Evans, Mary Jo Kreitzer
BACKGROUND: Many people suffering from low back pain (LBP) have found conventional medical treatments to be ineffective for managing their LBP and are increasingly turning to complementary and alternative medicine (CAM) to find pain relief. A comprehensive picture of CAM use in the LBP population, including all of the most commonly used modalities, is needed. STUDY OBJECTIVE: To examine prevalence and perceived benefit of CAM use within the US LBP population by limiting vs nonlimiting LBP and to evaluate the odds of past year CAM use within the LBP population...
January 2016: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/26937314/meeting-the-challenge-of-a-more-person-centered-future-for-us-healthcare
#5
Bonnie R Sakallaris, William L Miller, Robert Saper, Mary Jo Kreitzer, Wayne Jonas
No abstract text is available yet for this article.
January 2016: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/26937307/human-wellbeing-and-flourishing-if-not-now-when
#6
Mary Jo Kreitzer
No abstract text is available yet for this article.
January 2016: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/26833136/pathway-specific-remodeling-of-thalamostriatal-synapses-in-parkinsonian-mice
#7
Philip R L Parker, Arnaud L Lalive, Anatol C Kreitzer
Movement suppression in Parkinson's disease (PD) is thought to arise from increased efficacy of the indirect pathway basal ganglia circuit, relative to the direct pathway. However, the underlying pathophysiological mechanisms remain elusive. To examine whether changes in the strength of synaptic inputs to these circuits contribute to this imbalance, we obtained paired whole-cell recordings from striatal direct- and indirect-pathway medium spiny neurons (dMSNs and iMSNs) and optically stimulated inputs from sensorimotor cortex or intralaminar thalamus in brain slices from control and dopamine-depleted mice...
February 17, 2016: Neuron
https://www.readbyqxmd.com/read/26824660/cell-type-specific-control-of-brainstem-locomotor-circuits-by-basal-ganglia
#8
Thomas K Roseberry, A Moses Lee, Arnaud L Lalive, Linda Wilbrecht, Antonello Bonci, Anatol C Kreitzer
The basal ganglia (BG) are critical for adaptive motor control, but the circuit principles underlying their pathway-specific modulation of target regions are not well understood. Here, we dissect the mechanisms underlying BG direct and indirect pathway-mediated control of the mesencephalic locomotor region (MLR), a brainstem target of BG that is critical for locomotion. We optogenetically dissect the locomotor function of the three neurochemically distinct cell types within the MLR: glutamatergic, GABAergic, and cholinergic neurons...
January 28, 2016: Cell
https://www.readbyqxmd.com/read/26759174/kif17-regulates-rhoa-dependent-actin-remodeling-at-epithelial-cell-cell-adhesions
#9
Bipul R Acharya, Cedric Espenel, Fotine Libanje, Joel Raingeaud, Jessica Morgan, Fanny Jaulin, Geri Kreitzer
The kinesin KIF17 localizes at microtubule plus-ends where it contributes to regulation of microtubule stabilization and epithelial polarization. We now show that KIF17 localizes at cell-cell adhesions and that KIF17 depletion inhibits accumulation of actin at the apical pole of cells grown in 3D organotypic cultures and alters the distribution of actin and E-cadherin in cells cultured in 2D on solid supports. Overexpression of full-length KIF17 constructs or truncation mutants containing the N-terminal motor domain resulted in accumulation of newly incorporated GFP-actin into junctional actin foci, cleared E-cadherin from cytoplasmic vesicles and stabilized cell-cell adhesions to challenge with calcium depletion...
March 1, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/26665036/exploring-the-biofield
#10
Mary Jo Kreitzer, Rob Saper
No abstract text is available yet for this article.
November 2015: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/26665012/advancing-a-global-vision
#11
Mary Jo Kreitzer, Robert Saper
No abstract text is available yet for this article.
November 2015: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/26641815/pre-and-intrahospital-workflow-for-acute-stroke-treatment
#12
REVIEW
Charles Kircher, Natalie Kreitzer, Opeolu Adeoye
PURPOSE OF REVIEW: With the recent demonstration of the effectiveness of rapid recanalization of large vessel occlusions in acute ischemic stroke, it is important to assess the current status of pre and intrahospital workflow for acute stroke. RECENT FINDINGS: We will review trends in the evaluation and treatment of acute stroke and offer suggestions for how best to advance the workflow for acute stroke care in the coming years. SUMMARY: Future research is needed for: field use of clinical scores for predicting large vessel occlusions, telemedicine to facilitate prehospital triage, and pre and intrahospital processes for optimizing stroke care delivery...
February 2016: Current Opinion in Neurology
https://www.readbyqxmd.com/read/26558519/intracerebral-hemorrhage-in-anticoagulated-patients-evidence-based-emergency-department-management
#13
REVIEW
Natalie Kreitzer, Opeolu Adeoye
Spontaneous intracerebral hemorrhage is a true neurological emergency, and its management is made more complicated when patients are anticoagulated, as reversal of anticoagulation must be initiated simultaneously with diagnosis, treatment, and disposition. Recent advances such as newer laboratory testing and rapid computed tomography for diagnosis, blood pressure reduction to reduce hematoma expansion, and new anticoagulant reversal agents may allow for improved outcomes. Management of intracranial pressure is particularly important in anticoagulated patients, as is identifying patients who may benefit from rapid neurosurgical intervention and/or emergent transport to facilities capable of managing this disease...
December 2015: Emergency Medicine Practice
https://www.readbyqxmd.com/read/26494272/a-direct-path-to-action-initiation
#14
COMMENT
Christopher H Donahue, Anatol C Kreitzer
In this issue of Neuron, Sippy et al. (2015) provide the clearest evidence to date that information is differentially encoded in the direct and indirect pathways of the striatum. The results support the classical notion that the direct pathway plays a critical role in initiating actions.
October 21, 2015: Neuron
https://www.readbyqxmd.com/read/26421232/interprofessional-competencies-in-integrative-primary-healthcare
#15
Benjamin Kligler, Audrey J Brooks, Victoria Maizes, Elizabeth Goldblatt, Maryanna Klatt, Mary S Koithan, Mary Jo Kreitzer, Jeannie K Lee, Ana Marie Lopez, Hilary McClafferty, Robert Rhode, Irene Sandvold, Robert Saper, Douglas Taren, Eden Wells, Patricia Lebensohn
In October 2014, the National Center for Integrative Primary Healthcare (NCIPH) was launched as a collaboration between the University of Arizona Center for Integrative Medicine and the Academic Consortium for Integrative Health and Medicine and supported by a grant from the Health Resources and Services Administration. A primary goal of the NCIPH is to develop a core set of integrative healthcare (IH) competencies and educational programs that will span the interprofessional primary care training and practice spectra and ultimately become a required part of primary care education...
September 2015: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/26421225/the-wellbeing-of-the-workforce-in-healthcare-and-beyond
#16
Mary Jo Kreitzer
No abstract text is available yet for this article.
September 2015: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/26308981/optogenetics-10-years-after-chr2-in-neurons-views-from-the-community
#17
REVIEW
Antoine Adamantidis, Silvia Arber, Jaideep S Bains, Ernst Bamberg, Antonello Bonci, György Buzsáki, Jessica A Cardin, Rui M Costa, Yang Dan, Yukiko Goda, Ann M Graybiel, Michael Häusser, Peter Hegemann, John R Huguenard, Thomas R Insel, Patricia H Janak, Daniel Johnston, Sheena A Josselyn, Christof Koch, Anatol C Kreitzer, Christian Lüscher, Robert C Malenka, Gero Miesenböck, Georg Nagel, Botond Roska, Mark J Schnitzer, Krishna V Shenoy, Ivan Soltesz, Scott M Sternson, Richard W Tsien, Roger Y Tsien, Gina G Turrigiano, Kay M Tye, Rachel I Wilson
No abstract text is available yet for this article.
September 2015: Nature Neuroscience
https://www.readbyqxmd.com/read/26275677/review-of-thromboelastography-in-neurocritical-care
#18
REVIEW
Natalie P Kreitzer, Jordan Bonomo, Daniel Kanter, Christopher Zammit
No abstract text is available yet for this article.
December 2015: Neurocritical Care
https://www.readbyqxmd.com/read/25984409/integrative-nursing-around-the-globe
#19
Mary Jo Kreitzer
No abstract text is available yet for this article.
May 2015: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/25975378/dysregulation-of-locus-coeruleus-development-in-congenital-central-hypoventilation-syndrome
#20
Hiroko Nobuta, Maria Roberta Cilio, Olivier Danhaive, Hui-Hsin Tsai, Srinivasan Tupal, Sandra M Chang, Alice Murnen, Faith Kreitzer, Verenice Bravo, Catherine Czeisler, Hamza Numan Gokozan, Patrick Gygli, Sean Bush, Debra E Weese-Mayer, Bruce Conklin, Siu-Pok Yee, Eric J Huang, Paul A Gray, David Rowitch, José Javier Otero
Human congenital central hypoventilation syndrome (CCHS), resulting from mutations in transcription factor PHOX2B, manifests with impaired responses to hypoxemia and hypercapnia especially during sleep. To identify brainstem structures developmentally affected in CCHS, we analyzed two postmortem neonatal-lethal cases with confirmed polyalanine repeat expansion (PARM) or Non-PARM (PHOX2B∆8) mutation of PHOX2B. Both human cases showed neuronal losses within the locus coeruleus (LC), which is important for central noradrenergic signaling...
August 2015: Acta Neuropathologica
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