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https://www.readbyqxmd.com/read/28231598/evaluation-of-the-p16-and-ki-67-biomarkers-as-predictors-of-the-recurrence-of-premalignant-cervical-cancer-lesions-after-leep-conization
#1
Paulo Macêdo de Oliveira Leite, Luciene Tafuri, Maria Zélia de Oliveira Costa, Maria Inês de Miranda Lima, Renata Toscano Simões
Objective To evaluate the expressions of biomarkers p16 and Ki-67 in low-grade (LG) or high-grade (HG) lesions, and to relate them to risk factors and the recurrence of these lesions. Methods A retrospective case-control study of 86 patients with LG and HG lesions who underwent a loop electrosurgical excision procedure (LEEP) between 1999 and 2004. The control group was composed of 69 women with no recurrence, and the study group, of 17 patients with recurrence. All patients were followed-up over a two-year period after surgery, and screened every six months, including cytology and colposcopy...
February 23, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28231241/hydrocephalus-and-arthrogryposis-in-an-immunocompetent-mouse-model-of-zika-teratogeny-a-developmental-study
#2
Jose Xavier-Neto, Murilo Carvalho, Bruno Dos Santos Pascoalino, Alisson Campos Cardoso, Ângela Maria Sousa Costa, Ana Helena Macedo Pereira, Luana Nunes Santos, Ângela Saito, Rafael Elias Marques, Juliana Helena Costa Smetana, Silvio Roberto Consonni, Carla Bandeira, Vivian Vasconcelos Costa, Marcio Chaim Bajgelman, Paulo Sérgio Lopes de Oliveira, Marli Tenorio Cordeiro, Laura Helena Vega Gonzales Gil, Bianca Alves Pauletti, Daniela Campos Granato, Adriana Franco Paes Leme, Lucio Freitas-Junior, Carolina Borsoi Moraes Holanda de Freitas, Mauro Martins Teixeira, Estela Bevilacqua, Kleber Franchini
The teratogenic mechanisms triggered by ZIKV are still obscure due to the lack of a suitable animal model. Here we present a mouse model of developmental disruption induced by ZIKV hematogenic infection. The model utilizes immunocompetent animals from wild-type FVB/NJ and C57BL/6J strains, providing a better analogy to the human condition than approaches involving immunodeficient, genetically modified animals, or direct ZIKV injection into the brain. When injected via the jugular vein into the blood of pregnant females harboring conceptuses from early gastrulation to organogenesis stages, akin to the human second and fifth week of pregnancy, ZIKV infects maternal tissues, placentas and embryos/fetuses...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28231150/enhancing-the-total-phenolic-content-and-antioxidants-of-lemon-pomace-aqueous-extracts-by-applying-uv-c-irradiation-to-the-dried-powder
#3
Konstantinos Papoutsis, Quan V Vuong, Penta Pristijono, John B Golding, Michael C Bowyer, Christopher J Scarlett, Costas E Stathopoulos
Several studies have shown that UV-C (ultraviolet C) irradiation promotes the bioactive compounds and antioxidants of fresh fruits and vegetables. The aim of this study was to apply UV irradiation in dried lemon pomace powder for enhancing its phenolic content and antioxidant properties, thus more bioactive compounds should be available for extraction and utilization. Lemon pomace dried powder was placed under a UV lamp and treated with dosages of 4, 19, 80 and 185 kJ·m(-2), while untreated powder was used as a control...
August 23, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230986/design-synthesis-and-evaluation-of-a-novel-series-of-oxadiazine-gamma-secretase-modulators-for-familial-alzheimer-s-disease
#4
Matthew G Bursavich, Bryce A Harrison, Raksha Acharya, Donald E Costa, Emily A Freeman, Hilliary E Hodgdon, Lori A Hrdlicka, Hong Jin, Sudarshan Kapadnis, Jeffrey S Moffit, Deirdre A Murphy, Scott Nolan, Holger Patzke, Cuyue Tang, Melody Wen, Gerhard Koenig, Jean-François Blain, Duane A Burnett
Herein we describe the design, synthesis and evaluation of a novel series of oxadiazine-based gamma secretase modulators obtained via isosteric amide replacement and critical consideration of conforma-tional restriction. Oxadiazine lead 47 possesses good in vitro potency with excellent predicted CNS drug-like properties and desirable ADME/PK profile. This lead compound demonstrated robust Aβ42 reductions and subsequent Aβ37 increases in both rodent brain and CSF at 30 mg/kg dosed orally.
February 23, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28230714/assessment-of-skeletal-tumour-burden-on-18f-naf-pet-ct-using-a-new-quantitative-method
#5
Paula Lapa, Margarida Marques, Gracinda Costa, Andrei Iagaru, João Pedroso de Lima
PURPOSE: The purpose of this study was to test a method of quantifying skeletal tumour burden with F-NaF PET/CT. PATIENTS AND METHODS: We retrospectively reviewed the charts of 117 patients who underwent F-NaF PET/CT for the detection of bone metastases, 68 women and 49 men, 16-82 years old (mean±SD: 62.9±10.7 years). Mean standardized uptake values (SUVmean) were measured in five anatomic sites to evaluate normal skeleton activity. The influence of sex and age was investigated...
February 22, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28230493/using-correlative-light-and-electron-microscopy-to-understand-influenza-a-viral-assembly
#6
Ana Laura Sousa, Sílvia Vale-Costa, Maria João Amorim, Erin M Tranfield
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28230479/ultrastructural-features-of-cells-following-incubation-with-metal-complexes-using-phenanthroline-based-ligands-the-influence-of-the-metal-center
#7
Fernanda Marques, António Pedro Matos, Cristina P Matos, Isabel Correia, João Costa Pessoa, Maria Paula Campello
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28230468/the-role-of-transmission-electron-microscopy-in-vacuole-associated-myopathies
#8
Valentina Papa, Roberta Costa, Roberto D'Angelo, Rita Rinaldi, Elena Pegoraro, Marina Fanin, Corrado Angelini, Giovanna Cenacchi
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28230415/targeting-translational-successes-through-cansort-sci-using-pet-dogs-to-identify-effective-treatments-for-spinal-cord-injury
#9
Sarah A Moore, Nicolas Granger, Natasha Olby, Ingo Spitzbarth, Nick D Jeffery, Andrea Tipold, Yvette S Nout-Lomas, Ronaldo da Costa, Veronika Stein, Linda Noble-Haeusslein, Andrew R Blight, Robert Grossman, D Michele Basso, Jonathan Michael Levine
Translation of therapeutic interventions for spinal cord injury (SCI) from laboratory to clinic has been historically challenging, highlighting the need for robust models of injury that more closely mirror the human condition. The high prevalence of acute, naturally occurring SCI in pet dogs provides a unique opportunity to expeditiously evaluate promising interventions in a population of animals that are diagnosed and managed clinically in a manner similar to spinal cord-injured people, while adhering to NIH guidelines for scientific rigor and transparent reporting...
February 23, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28230070/an-fmri-compatible-force-measurement-system-for-the-evaluation-of-the-neural-correlates-of-step-initiation
#10
Andrea Cristina de Lima-Pardini, Raymundo Machado de Azevedo Neto, Daniel Boari Coelho, Catarina Costa Boffino, Sukhwinder S Shergill, Carolina de Oliveira Souza, Rachael Brant, Egberto Reis Barbosa, Ellison Fernando Cardoso, Luis Augusto Teixeira, Rajal G Cohen, Fay Bahling Horak, Edson Amaro
Knowledge of brain correlates of postural control is limited by the technical difficulties in performing controlled experiments with currently available neuroimaging methods. Here we present a system that allows the measurement of anticipatory postural adjustment of human legs to be synchronized with the acquisition of functional magnetic resonance imaging data. The device is composed of Magnetic Resonance Imaging (MRI) compatible force sensors able to measure the level of force applied by both feet. We tested the device in a group of healthy young subjects and a group of elderly subjects with Parkinson's disease using an event-related functional MRI (fMRI) experiment design...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229846/-diagnostic-and-therapeutic-approach-of-chronic-spontaneous-urticaria-recommendations-in-portugal
#11
Célia Costa, Margarida Gonçalo
Chronic spontaneous urticaria is a complex disorder, of unclear etiology, easily diagnosed although often difficult to treat. It has a significant impact on the patients' quality of life and results in high direct and indirect costs. The diagnosis of chronic spontaneous urticaria is mainly clinical and a limited number of tests is recommended for differential diagnosis and/or for the investigation/exclusion of possible causes. In addition to the complete blood count and C-reactive protein, and/or erythrocyte sedimentation rate, additional tests must be selected according to clinical criteria...
November 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28229841/-neuroimaging-and-blood-biomarkers-in-functional-prognosis-after-stroke
#12
REVIEW
João Paulo Branco, Joana Santos Costa, João Sargento-Freitas, Sandra Oliveira, Bruno Mendes, Jorge Laíns, João Pinheiro
INTRODUCTION: Stroke remains one of the leading causes of morbidity and mortality around the world and it is associated with an important long-term functional disability. Some neuroimaging resources and certain peripheral blood or cerebrospinal fluid proteins can give important information about etiology, therapeutic approach, follow-up and functional prognosis in acute ischemic stroke patients. However, among the scientific community, there is currently more interest in the stroke vital prognosis over the functional prognosis...
November 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28229481/cross-reactivity-of-commercial-anti-dengue-immunoassays-in-patients-with-acute-zika-virus-infection
#13
Alvina Clara Felix, Nathalia C Santiago Souza, Walter M Figueiredo, Angela A Costa, Marta Inenami, Rosangela Mg da Silva, José Eduardo Levi, Claudio Sergio Pannuti, Camila Malta Romano
Several countries have local transmission of multiple arboviruses, in particular, dengue and Zika viruses, which have recently spread through many American countries. Cross reactivity among Flaviviruses is high and present a challenge for accurate identification of the infecting agent. Thus, we evaluated the level of cross reactivity of anti-dengue IgM/G Enzyme-Linked Immunosorbent Assays (ELISA) from three manufacturers against 122 serum samples obtained at two time-points from 61 patients with non-dengue confirmed Zika virus infection...
February 23, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28229451/honokiol-protects-skin-cells-against-inflammation-collagenolysis-apoptosis-and-senescence-caused-by-cigarette-smoke-damage
#14
Adilson Costa, Gustavo Facchini, Ana Lúcia T A Pinheiro, Michelle S da Silva, Michael Y Bonner, Jack Arbiser, Samara Eberlin
BACKGROUND: Pollution, especially cigarette smoke, is a major cause of skin damage. OBJECTIVES: To assess the effects of the small molecule polyphenol, honokiol, on reversing cigarette smoke-induced damage in vitro to relevant skin cells. METHODS: Keratinocytes (HaCat) cultures were exposed to cigarette smoke and, after 48 hours, IL-1α and IL-8 were measured in cell supernatants. Moreover, TIMP-2 production, apoptosis rate, and senescence β-galactosidase expression were evaluated in primary human foreskin fibroblasts (HFF-1) cultures...
February 22, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28228766/cell-wall-remodeling-in-abscission-zone-cells-during-ethylene-promoted-fruit-abscission-in-citrus
#15
Paz Merelo, Javier Agustí, Vicent Arbona, Mário L Costa, Leandro H Estornell, Aurelio Gómez-Cadenas, Silvia Coimbra, María D Gómez, Miguel A Pérez-Amador, Concha Domingo, Manuel Talón, Francisco R Tadeo
Abscission is a cell separation process by which plants can shed organs such as fruits, leaves, or flowers. The process takes place in specific locations termed abscission zones. In fruit crops like citrus, fruit abscission represents a high percentage of annual yield losses. Thus, understanding the molecular regulation of abscission is of capital relevance to control production. To identify genes preferentially expressed within the citrus fruit abscission zone (AZ-C), we performed a comparative transcriptomics assay at the cell type resolution level between the AZ-C and adjacent fruit rind cells (non-abscising tissue) during ethylene-promoted abscission...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28228688/two-new-species-and-a-new-combination-in-protium-burseraceae-from-costa-rica
#16
Daniel Santamaría-Aguilar, Laura P Lagomarsino
Two new species of Protium (Burseraceae) are described and illustrated: Protium aguilariisp. nov., from the Pacific slope of the Osa Peninsula, Puntarenas Province, Costa Rica; and Protium hammeliisp. nov., from wet forests on the Caribbean slopes of Nicaragua and Costa Rica. In addition, Protium brenesiicomb. nov., is proposed as a new combination based on Trichilia brenesii, a name that was based on a specimen collected with flowers in the mountains near San Ramón, Alajuela Province, Costa Rica. It is compared with Protium costaricense, a similar species with which it has been confused for more than 90 years...
2017: PhytoKeys
https://www.readbyqxmd.com/read/28228667/three-new-species-of-the-killifish-genus-melanorivulus-from-the-central-brazilian-cerrado-savanna-cyprinodontiformes-aplocheilidae
#17
Wilson J E M Costa
Three new species are described from the Neotropical region comprising the Cerrado savannas of the central Brazilian plateaus, which is among the most important biodiversity centres in the world. These species are considered closely related to Melanorivulus dapazi from the same region, with which they share the presence of a rudimentary interarcual cartilage and a dark reddish brown distal margin on the male anal fin. The group comprising Melanorivulus dapazi and the three new species is here named as the Melanorivulus dapazi species group...
2017: ZooKeys
https://www.readbyqxmd.com/read/28228155/catecholamines-as-outcome-markers-in-isolated-traumatic-brain-injury-the-coma-tbi-study
#18
Sandro B Rizoli, Blessing N R Jaja, Alex P Di Battista, Shawn G Rhind, Antonio Capone Neto, Leodante da Costa, Kenji Inaba, Luis Teodoro da Luz, Bartolomeu Nascimento, Adic Perez, Andrew J Baker, Airton Leonardo de Oliveira Manoel
BACKGROUND: Elevated catecholamine levels might be associated with unfavorable outcome after traumatic brain injury (TBI). We investigated the association between catecholamine levels in the first 24 h post-trauma and functional outcome in patients with isolated moderate-to-severe TBI. METHODS: A cohort of 174 patients who sustained isolated blunt TBI was prospectively enrolled from three Level-1 Trauma Centers. Epinephrine (Epi) and norepinephrine (NE) concentrations were measured at admission (baseline), 6, 12 and 24 h post-injury...
February 23, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28228142/change-in-anopheles-richness-and-composition-in-response-to-artificial-flooding-during-the-creation-of-the-jirau-hydroelectric-dam-in-porto-velho-brazil
#19
Moreno S Rodrigures, Elis P Batista, Alexandre A Silva, Fábio M Costa, Verissimo A S Neto, Luiz Herman S Gil
BACKGROUND: Anopheles mosquitoes are the only vectors of human malaria. Anopheles species use standing water as breeding sites. Human activities, like the creation of an artificial lake during the implementation of hydroelectric power plants, lead to changes in environmental characteristics and, therefore, may changes the species richness and composition of Anopheles mosquitoes. The aim of the present study was to verify whether or not there is an association between the artificial flooding resulting from the construction of the Jirau hydroelectric power plant, and the richness and composition of anophelines...
February 22, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28227982/analysis-of-the-sleep-eeg-in-the-complexity-domain
#20
Sara Mariani, Ana F T Borges, Teresa Henriques, Robert J Thomas, Samuel J Leistedt, Paul Linkowski, Jean-Pol Lanquart, Ary L Goldberger, Madalena D Costa, Sara Mariani, Ana F T Borges, Teresa Henriques, Robert J Thomas, Samuel J Leistedt, Paul Linkowski, Jean-Pol Lanquart, Ary L Goldberger, Madalena D Costa, Teresa Henriques, Robert J Thomas, Madalena D Costa, Samuel J Leistedt, Paul Linkowski, Ary L Goldberger, Jean-Pol Lanquart, Sara Mariani, Ana F T Borges
Conventional sleep analysis relies primarily on electroencephalogram (EEG) waveform features assessed in concert with eye movements, respiration and muscle tone. We explore a complementary "complexity domain" approach based on multiscale entropy (MSE) analysis of EEG signals and discuss its relationships to standard sleep analysis and to that based on electrocardiogram (ECG)-derived cardiopulmonary coupling (CPC). We observe a progressive decrease in complexity associated with decreased arousability, as measured by both conventional sleep scoring and CPC analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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