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https://www.readbyqxmd.com/read/28938784/immunocastration-as-an-alternative-to-caponization-evaluation-of-its-effect-on-body-and-bone-development-and-on-meat-color-and-composition
#1
M A G Quaresma, I C Antunes, M F Ribeiro, S Prazeres, R J B Bessa, P Martins da Costa
Caponization is associated with some morbidity and mortality, which contributes to important economic losses. This practice is executed without any pain relief (neither anesthesia nor analgesia) and can be painful and without consideration of animal welfare. On the other hand, immunocastration accomplished by Improvac and Bovipriva in pigs and cattle represents a noninvasive procedure, and for that reason is regarded as an alternative with improved animal welfare. This study includes 4 experimental groups consisting of capons, slips, roosters, and birds submitted to the Improvac treatment...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938405/short-term-high-fat-diet-increases-leptin-activation-of-cart-neurons-and-advances-puberty-in-female-mice
#2
Jade Cabestre Venancio, Lisandra Oliveira Margatho, Rodrigo C Rorato, Roberta Ribeiro Costa Rosales, Lucas Kniess Debarba, Ricardo Coletti, Jose Antunes-Rodrigues, Carol F Elias, Lucila Leico K Elias
Leptin is a permissive factor for puberty initiation, participating as a metabolic cue in the activation of the kisspeptin (Kiss1)-gonadotropin-releasing hormone neuronal circuitry however, it has no direct effect on Kiss1 neurons. Leptin acts on hypothalamic CART neurons, participating in the regulation of energy homeostasis. We investigated the influence of a short-term high-fat diet (HFD) on the effect of leptin on puberty timing. Kiss1-hrGFP female mice received a HFD or regular diet (RD) after weaning at postnatal day 21 (PN21) and were studied at PN28 and PN32...
September 4, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938195/understanding-public-perception-of-hydraulic-fracturing-a-case-study-in-spain
#3
D Costa, V Pereira, J Góis, A Danko, A Fiúza
Public acceptance is crucial for the implementation of energy technologies. Hydraulic fracturing is a technology widely used in the USA for natural gas production from shale formations, but currently finds strong public opposition worldwide, especially in Europe. Shale gas exploitation and exploration have the potential to significantly reduce import dependency in several countries, including Spain. To better understand public opinion on this issue, this article reports a survey targeting both the entire Spanish population and the inhabitants of the province of Burgos, the location where shale gas exploration permits have already been issued...
September 19, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28938177/the-osmotin-of-calotropis-procera-latex-is-not-expressed-in-laticifer-free-cultivated-callus-and-under-salt-stress
#4
Isabel C C Souza, Márcio V Ramos, José H Costa, Cleverson D T Freitas, Raquel S B Oliveira, Frederico B Moreno, Renato A Moreira, Cristina P S Carvalho
The latex of Calotropis procera has previously been reported to contain osmotin. This protein (CpOsm) inhibited phytopathogens and this was mechanistically characterized. Here, the time-course profile of CpOsm transcripts was examined in the salt-stressed cultivated callus of C. procera in order to better understand its role in the physiology of the plant. Stressed callus (80 mM NaCl) showed an unbalanced content of organic compounds (proline and total soluble sugar) and inorganic ions (Na(+), Cl(-), and K(+))...
September 14, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28937989/limited-synapse-overproduction-can-speed-development-but-sometimes-with-long-term-energy-and-discrimination-penalties
#5
Harang Ju, Costa M Colbert, William B Levy
Neural circuit development requires that synapses be formed between appropriate neurons. In addition, for a hierarchical network, successful development involves a sequencing of developmental events. It has been suggested that one mechanism that helps speed up development of proper connections is an early overproduction of synapses. Using a computational model of synapse development, such as adaptive synaptogenesis, it is possible to study such overproduction and its role in speeding up development; it is also possible to study other outcomes of synapse overproduction that are seemingly new to the literature...
September 22, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28937962/portable-functional-neuroimaging-as-an-environmental-epidemiology-tool-a-how-to-guide-for-the-use-of-fnirs-in-field-studies
#6
Joseph M Baker, Daniel Rojas-Valverde, Randall Gutiérrez, Mirko Winkler, Samuel Fuhrimann, Brenda Eskenazi, Allan L Reiss, Ana M Mora
The widespread application of functional neuroimaging within the field of environmental epidemiology has the potential to greatly enhance our understanding of how environmental toxicants affect brain function. Because many epidemiological studies take place in remote and frequently changing environments, it is necessary that the primary neuroimaging approach adopted by the epidemiology community be robust to many environments, easy to use, and, preferably, mobile. Here, we outline our use of functional near-infrared spectroscopy (fNIRS) to collect functional brain imaging data from Costa Rican farm workers enrolled in an epidemiological study on the health effects of chronic pesticide exposure...
September 21, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28937896/evaluation-of-oral-health-related-quality-of-life-to-assess-dental-treatment-in-preschool-children-with-early-childhood-caries-a-preliminary-study
#7
Ana Lúcia Vollú, Maria da Encarnação Perez Requejo da Costa, Lucianne Cople Maia, Andréa Fonseca-Gonçalves
PURPOSE: The oral health-related quality of life (OHRQoL) of preschool children with Early Childhood Caries (ECC) was used to assess the outcome of dental treatment. STUDY DESIGN: Children (3.56±1.31years) affected by ECC were selected. Anamnesis, clinical and radiographic exams were performed. Data about sociodemographic aspects, OHRQoL and dmf-t index were collected. The Brazilian version of Early Childhood Oral health Impact Scale (B-ECOHIS) was applied in two time intervals: before and after 30 days of treatment...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937430/cutaneous-richter-syndrome-mimicking-primary-cutaneous-cd4-positive-small-medium-t-cell-lymphoma-case-report-and-review-of-the-literature
#8
Miguel Rito, José Cabeçadas, Joaninha Costa Rosa, Mariana Cravo, Alistair Robson
Richter syndrome represents the transformation of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma into an aggressive large B-cell lymphoma. Skin involvement is exceptionally rare, with <20 cases reported and its presence as the first presentation of CLL/small lymphocytic lymphoma, as an isolated skin lesion has never been described. Primary cutaneous CD4-positive small/medium T-cell lymphoma (CD4 PCSM-TCL) characteristically presents with a dense dermal infiltrate consisting primarily of small-/medium-sized pleomorphic T-cells and less than 30% large pleomorphic cells...
September 12, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28937354/energy-contribution-of-nova-food-groups-and-sociodemographic-determinants-of-ultra-processed-food-consumption-in-the-mexican-population
#9
Joaquín A Marrón-Ponce, Tania G Sánchez-Pimienta, Maria Laura da Costa Louzada, Carolina Batis
OBJECTIVE: To identify the energy contributions of NOVA food groups in the Mexican diet and the associations between individual sociodemographic characteristics and the energy contribution of ultra-processed foods (UPF). DESIGN: We classified foods and beverages reported in a 24 h recall according to the NOVA food framework into: (i) unprocessed or minimally processed foods; (ii) processed culinary ingredients; (iii) processed foods; and (iv) UPF. We estimated the energy contribution of each food group and ran a multiple linear regression to identify the associations between sociodemographic characteristics and UPF energy contribution...
September 22, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28936655/immunolocalization-of-agps-and-pectins-in-quercus-suber-gametophytic-structures
#10
Mário Luís da Costa, Ana Lúcia Lopes, Maria Isabel Amorim, Sílvia Coimbra
The arabinogalactan proteins (AGPs) are highly glycosylated proteins, ubiquitous in plants that have been linked to numerous aspects of sexual reproduction in several plant species, including the monoecious tree species Quercus suber. AGPs are found in cell membranes and cell walls of all types of tissues, including reproductive cells and organs. Pectins are cell wall components that also have been shown to change in composition and quantity during the maturations of the male and female gametophyte in cork oak...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28936201/trichoderma-asperelloides-spores-downregulate-dectin1-2-and-tlr2-receptors-of-mice-macrophages-and-decrease-candida-parapsilosis-phagocytosis-independent-of-the-m1-m2-polarization
#11
Andréa G Dos Santos, Érica A Mendes, Rafael P de Oliveira, Ana M C Faria, Aurizangela O de Sousa, Carlos P Pirovani, Fernanda F de Araújo, Andréa T de Carvalho, Marliete Carvalho Costa, Daniel Assis Santos, Quimi V Montoya, Andre Rodrigues, Jane L Dos Santos
The intensive use of pesticides to control pests in agriculture has promoted several issues relating to environment. As chemical pesticides remain controversial, biocontrol agents originating from fungi could be an alternative. Among them, we highlight biocontrol agents derived from the fungi genus Trichoderma, which have been documented in limiting the growth of other phytopathogenic fungus in the roots and leaves of several plant species. An important member of this genus is Trichoderma asperelloides, whose biocontrol agents have been used to promote plant growth while also treating soil diseases caused by microorganisms in both greenhouses and outdoor crops...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28936100/multiple-inherited-thrombophilias-in-a-young-patient-with-striatocapsular-stroke
#12
Isabel Taveira, Cláudia Vicente, Sofia Sobral, Hipólito Nzwalo, José Sousa E Costa
No abstract text is available yet for this article.
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28935683/synaptic-activation-of-putative-sensory-neurons-by-hexamethonium-sensitive-nerve-pathways-in-mouse-colon
#13
Timothy James Hibberd, Lee Travis, Lukasz Wiklendt, Marcello C Costa, Simon J H Brookes, Hongzhen Hu, Damien John Keating, Nick J Spencer
The gastrointestinal tract contains its own independent population of sensory neurons within the gut wall. These sensory neurons have been referred to as intrinsic primary afferent neurons (IPANs) and can be identified by immunoreactivity to calcitonin gene related peptide (CGRP) in mice. A common feature of IPANs is a paucity of fast synaptic inputs observed during sharp microelectrode recordings. Whether this is observed using different recording techniques is of particular interest for understanding the physiology of these neurons and neural circuit modelling...
September 21, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28935591/evidence-that-p-glycoprotein-inhibitor-elacridar-loaded-nanocarriers-improve-epidermal-targeting-of-an-anticancer-drug-via-absorptive-cutaneous-transporters-inhibition
#14
Daniela V Giacone, Vanessa F M Carvalho, Soraia K P Costa, Luciana B Lopes
Because P-glycoprotein (P-gp) plays an absorptive role in the skin, its pharmacological inhibition represents a strategy to promote cutaneous localization of anticancer agents that serve as its substrates, improving local efficacy while reducing systemic exposure. Here, we evaluated the ability of a nanoemulsion (NE) co-encapsulating a P-gp inhibitor (elacridar) with the antitumor drug paclitaxel to promote epidermal targeting. Loaded NE displayed a nanometric size (45.2±4.0 nm) and negative zeta potential (-4...
September 18, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28935551/anti-trypanosoma-anti-leishmania-and-cytotoxic-activities-of-natural-products-from-psidium-brownianum-mart-ex-dc-and-psidium-guajava-var-pomifera-analysed-by-lc-ms
#15
Celestina Elba Sobral de Souza, Ana Raquel Pereira da Silva, Maria Celeste Vega Gomez, Míriam Rolóm, Cathia Coronel, José Galberto Martins da Costa, Amanda K Sousa, Larissa A Rolim, Francisco Hugo Sobral de Souza, Henrique Douglas Melo Coutinho
Neglected diseases are those that are prevalent in developing countries, even with a rich biodiversity. These diseases still persist because of the lack of scientific studies, government negligence or failures of the public health system. This study aims to identify the composition of extracts and fractions from Psidium brownianum and Psidium guajava through LC-MS, to evaluate its in vitro anti-parasitic and cytotoxic activity against Trypanosoma cruzi, Leishmania brasiliensis and L. infantum epismastigote and promastigote forms, as well as mammalian cells...
September 18, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28935464/effectiveness-and-safety-of-oral-anticoagulation-with-non-vitamin-k-antagonists-compared-to-well-managed-vitamin-k-antagonists-in-na%C3%A3-ve-patients-with-non-valvular-atrial-fibrillation-propensity-score-matched-cohort-study
#16
Gentian Denas, Nicola Gennaro, Eliana Ferroni, Ugo Fedeli, Mario Saugo, Giacomo Zoppellaro, Seena Padayattil Jose, Giorgio Costa, Maria Chiara Corti, Margherita Andretta, Vittorio Pengo
BACKGROUND: The global real-life impact of non-vitamin K antagonist oral anticoagulants (NOACs) introduction in the healthcare system in a setting of well-managed vitamin K antagonist (VKA) therapy has not been specifically addressed. METHODS: We did a population-based retrospective cohort study in naïve patients initiating oral anticoagulants for stroke prevention in atrial fibrillation in a region with a well-managed VKA therapy. NOAC and VKA cohorts were identified using Anatomical Therapeutic Chemical (ATC) codes, while excluding other indications for anticoagulation therapy using ICD-9CM codes...
September 18, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28935426/cis-rucl-bzcn-bipy-dppe-pf6-induces-anti-angiogenesis-and-apoptosis-by-a-mechanism-of-caspase-dependent-involving-dna-damage-parp-activation-and-tp53-induction-in-ehrlich-tumor-cells
#17
Lorena Félix Magalhães, Francyelli Mello-Andrade, Wanessa Carvalho Pires, Hugo Delleon Silva, Larissa Matuda Macedo, Carlos Henrique de Castro, Cristiene Costa Carneiro, Clever Gomes Cardoso, Paulo Roberto de Melo Reis, Laís Camargo de Oliveira, Renata Rodrigues Caetano, Alzir A Batista, Elisângela de Paula Silveira-Lacerda
Antimetastatic activities, low toxicity to normal cells and high selectivity for tumor cells make of the ruthenium complexes promising candidates in the search for develop new chemotherapeutic agents for the treatment of cancer. This study aimed to determine the cytotoxic, genotoxic and to elucidate the signaling pathway involved in the death cell process induced by cis-[RuCl(BzCN) (bipy) (dppb)]PF6(1) and cis-[RuCl(BzCN) (bipy) (dppe)]PF6(2) in Ehrlich ascites carcinoma (EAC) in vitro. Moreover, we report for the first time the anti-angiogenic potential on chick embryo chorioallantoic membrane (CAM) model...
September 18, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28935290/objectives-and-methodology-of-biobadaser-phase-iii
#18
Carlos Sanchez-Piedra, M Victoria Hernández Miguel, Javier Manero, Rosa Roselló, Jesús Tomás Sánchez-Costa, Carlos Rodríguez-Lozano, Cristina Campos, Eduardo Cuende, Jesús Carlos Fernández-Lopez, Sagrario Bustabad, Raquel Martín Domenech, Eva Pérez-Pampín, Javier Del Pino-Montes, Ana Milena Millan-Arcineas, Federico Díaz-González, Juan Jesús Gómez-Reino
OBJECTIVE: Describe the objectives, methods and results of the first year of the new version of the Spanish registry of adverse events involving biological therapies and synthetic drugs with an identifiable target in rheumatic diseases (BIOBADASER III). METHODOLOGY: Multicenter prospective registry of patients with rheumatic inflammatory diseases being treated with biological drugs or synthetic drugs with an identifiable target in rheumatology departments in Spain...
September 18, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28935075/6-month-clinical-and-angiographic-outcomes-of-a-novel-radiopaque-sirolimus-eluting-bioresorbable-vascular-scaffold-the-fantom-ii-study
#19
Alexandre Abizaid, Didier Carrié, Norbert Frey, Matthias Lutz, Joachim Weber-Albers, Darius Dudek, Bernard Chevalier, Shu-Chuan Weng, Ricardo A Costa, Jeffrey Anderson, Gregg W Stone
OBJECTIVES: The purpose of this study was to evaluate the outcomes of the novel Fantom coronary bioresorbable scaffold at 6 months. BACKGROUND: The Fantom sirolimus-eluting bioresorbable scaffold incorporates a unique proprietary iodinated, polycarbonate copolymer of tyrosine analogs that is radiopaque, with thin struts (125 μm) that facilitate device delivery and precise target lesion treatment. METHODS: The 6-month outcomes and performance of the Fantom scaffold were evaluated in 117 patients with single de novo native coronary artery lesions of length ≤20 mm and reference vessel diameter 2...
September 25, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28934645/graphene-a-new-activator-of-sodium-persulfate-for-the-advanced-oxidation-of-parabens-in-water
#20
Leonidas Bekris, Zacharias Frontistis, George Trakakis, Lamprini Sygellou, Costas Galiotis, Dionissios Mantzavinos
Graphene was successfully employed as a catalyst for the activation of sodium persulfate, towards the effective degradation of propylparaben, an emerging micro-pollutant, representative of the parabens family. A novel process is proposed which utilizes a commercial graphene nano-powder as the catalyst and sodium persulfate as the oxidizing agent. It was found that over 95% of micro-pollutant degradation occurs within 15 min of reaction time. The effects of catalyst loading (75 mg/L to 1 g/L), sodium persulfate (SPS) concentration (10 mg/L to 1 g/L), initial solution pH (3-9) and initial paraben concentration (0...
September 13, 2017: Water Research
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