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https://www.readbyqxmd.com/read/28431322/xanthohumol-and-8-prenylnaringenin-ameliorate-diabetic-related-metabolic-dysfunctions-in-mice
#1
Raquel Costa, Ilda Rodrigues, Luísa Guardão, Sílvia Rocha-Rodrigues, Carolina Silva, José Magalhães, Manuel Ferreira-de-Almeida, Rita Negrão, Raquel Soares
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skeletal muscle lipid and glycolytic metabolism in T2DM mice model. Thirty C57Bl/6 mice were randomly divided into five groups: standard diet (control), high-fat diet (DM), high-fat diet plus ethanol (DM-Ethanol), high-fat diet plus 10 mg/L XN (DM-XN) and high-fat diet plus 10 mg/L 8PN (DM-8PN) during 20 weeks...
April 6, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28431215/early-treatment-improves-urodynamic-prognosis-in-neurogenic-voiding-dysfunction-20-years-of-experience
#2
Lucia M Costa Monteiro, Glaura O Cruz, Juliana M Fontes, Eliane T R C Vieira, Eloá N Santos, Grace F Araújo, Eloane G Ramos
OBJECTIVE: To evaluate the association between early treatment and urodynamic improvement in pediatric and adolescent patients with neurogenic bladder. METHODOLOGY: Retrospective longitudinal and observational study (between 1990 and 2013) including patients with neurogenic bladder and myelomeningocele treated based on urodynamic results. The authors evaluated the urodynamic follow-up (bladder compliance and maximum bladder capacity and pressure) considering the first urodynamic improvement in two years as the outcome variable and early referral as the exposure variable, using a descriptive and multivariate analysis with logistic regression model...
April 18, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28430793/identifying-a-combined-construct-of-grief-and-explosive-anger-as-a-response-to-injustice-amongst-survivors-of-mass-conflict-a-latent-class-analysis-of-data-from-timor-leste
#3
Susan J Rees, Alvin Kuowei Tay, Elisa Savio, Zelia Maria Da Costa, Derrick Silove
Previous studies have identified high rates of explosive anger amongst post-conflict populations including Timor-Leste. We sought to test whether explosive anger was integrally associated with symptoms of grief amongst the Timorese, a society that has experienced extensive conflict-related losses. In 2010 and 2011 we recruited adults (n = 2964), 18-years and older, living in an urban and a rural village in Timor-Leste. We applied latent class analysis to identify subpopulations based on symptoms of explosive anger and grief...
2017: PloS One
https://www.readbyqxmd.com/read/28430669/low-previous-cardiovascular-risk-of-patients-with-st-elevation-myocardial-infarction
#4
Gustavo Rodrigues, Pedro de Araújo Gonçalves, Francisco Moscoso Costa, Rui Campante Teles, Dores Hélder, Luís Mariano, João Brito, Henrique Mesquita Gabriel, Manuel Almeida, Miguel Mendes
BACKGROUND: Myocardial infarction is frequently the initial form of presentation of coronary artery disease (CAD). Systemic Coronary Risk Estimation (SCORE) risk tables are used in primary prevention and provide an estimate of cardiovascular (CV) risk through known risk factors. The aim of this study was to evaluate the performance of the SCORE, calculated using data previous to the event, to estimate CV risk of a population of patients presenting with ST-elevation myocardial infarction (STEMI) as the first manifestation of CAD...
April 20, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28429850/association-of-obstructive-sleep-apnea-with-arterial-stiffness-and-nondipping-blood-pressure-in-patients-with-hypertension
#5
Raimundo Jenner, Fernanda Fatureto-Borges, Valéria Costa-Hong, Heno F Lopes, Sandra H Teixeira, Elias Marum, Dante A M Giorgi, Fernanda M Consolim-Colombo, Luiz A Bortolotto, Geraldo Lorenzi-Filho, Eduardo M Krieger, Luciano F Drager
Whether sex influences the association of obstructive sleep apnea (OSA) with markers of cardiovascular risk in patients with hypertension is unknown. In this study, 95 hypertensive participants underwent carotid-femoral pulse wave velocity, 24-hour ambulatory blood pressure monitoring, echocardiogram, and polysomnography after a 30-day standardized treatment with hydrochlorothiazide plus enalapril or losartan. OSA was present in 52 patients. Compared with non-OSA patients, pulse wave velocity values were higher in the OSA group (men: 11...
April 21, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28429777/interleukin-6-increases-the-expression-and-activity-of-insulin-degrading-enzyme
#6
Mirian A Kurauti, José M Costa-Júnior, Sandra M Ferreira, Gustavo J Santos, Carlos H G Sponton, Everardo M Carneiro, Guilherme D Telles, Mara P T Chacon-Mikahil, Cláudia R Cavaglieri, Luiz F Rezende, Antonio C Boschero
Impairment of the insulin-degrading enzyme (IDE) is associated with obesity and type 2 diabetes mellitus (T2DM). Here, we used 4-mo-old male C57BL/6 interleukin-6 (IL-6) knockout mice (KO) to investigate the role of this cytokine on IDE expression and activity. IL-6 KO mice displayed lower insulin clearance in the liver and skeletal muscle, compared with wild type (WT), due to reduced IDE expression and activity. We also observed that after 3-h incubation, IL-6, 50 and 100 ng ml(-1), increased the expression of IDE in HEPG2 and C2C12 cells, respectively...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429640/spinal-alterations-of-reil-insula-in-alzheimer-s-disease
#7
Foivos E Petrides, Ioannis A Mavroudis, Martha Spilioti, Fotios G Chatzinikolaou, Vasiliki G Costa, Stavros J Baloyannis
Alzheimer's disease (AD) is a progressive neurodegenerative disease that involves numerous cellular and biochemical mechanisms resulting in synaptic alterations and extensive neuronal loss. It is primarily characterized by impairment of memory, associated frequently with mood disorders. Continuous studies have shown that insula may be an important target of AD, but neuropathological alterations have not been described extensively. In the present study, we attempted to describe the morphometric and morphological changes of the spines of Reil insula in AD in comparison with normal aging using a silver impregnation technique...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28429382/technical-note-direct-measurement-of-clinical-mammographic-x-ray-spectra-using-a-cdte-spectrometer
#8
Josilene C Santos, Alessandra Tomal, Tânia A Furquim, Agnes M F Fausto, Maria S Nogueira, Paulo R Costa
PURPOSE: To introduce and evaluate a method developed for the direct measurement of mammographic x-ray spectra using a CdTe spectrometer. The assembly of a positioning system and the design of a simple and customized alignment device for this application is described. METHODS: A positioning system was developed to easily and accurately locate the CdTe detector in the x-ray beam. Additionally, an alignment device to line up the detector with the central axis of the radiation beam was designed...
April 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28429193/effect-of-non-coherent-infrared-light-led-%C3%AE-945%C3%A2-%C3%A2-%C3%A2-20%C3%A2-nm-on-bone-repair-in-diabetic-rats-morphometric-and-spectral-analyses
#9
Alexandre Greca Diamantino, Renata Amadei Nicolau, Davidson Ribeiro Costa, Alessandra Paes de Barros Almeida, Danila Xênia de Miranda Mato, Marco Antonio de Oliveira, Ana Maria do Espírito Santo
Phototherapy using coherent light (lasers) and non-coherent light (light-emitting diodes (LEDs)) has been investigated for the purpose of biomodulation in biological tissues. Several effects can be expected, including pain moderation, biostimulation of cellular tropism, anti-inflammatory effects, regular circulatory stimulation, and tissue repair. The aim of this study was to evaluate the effect of LED (λ945 ± 20 nm, 48 mW) therapy on the regeneration process in femoral lesions of rats (Wistar). Seven irradiation sessions were held, with a 48-h interval between sessions...
April 20, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28429190/study-on-environmental-indices-and-heat-tolerance-tests-in-hair-sheep
#10
L Seixas, C B de Melo, A M Menezes, A F Ramos, G R Paludo, V Peripolli, C B Tanure, J B G Costa Junior, C McManus
The ability to predict the effects of climatic factors on animals and their adaptability is important for livestock production. The aim of the present study was to analyze whether existing indices are suitable for evaluating heat stress in Santa Ines and Morada Nova sheep, which are locally adapted hair sheep breeds from northeastern Brazil, and if the limits used to classify thermal stress are suitable for these breeds. Therefore, climatic, physiological, and physical parameters, as well as thermographic images, were collected in 26 sheep, 1 1/2 years old, from two genetic groups (Santa Ines 12 males and 4 females; Morada Nov...
April 20, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28429045/assessment-of-the-alpha-angle-and-mobility-of-the-hip-in-patients-with-noncontact-anterior-cruciate-ligament-injury
#11
Osmar Valadao Lopes, Gustavo Tragnago, Cristiano Gatelli, Rogério Nascimento Costa, Leandro de Freitas Spinelli, Paulo Renato Fernandes Saggin, André Kuhn
PURPOSE: To evaluate the alpha angle of the hip in patients with noncontact anterior cruciate ligament (ACL) injury and compare it with patients without injury. In addition, external and internal rotation of the hip was assessed and correlated with the alpha angle. METHODS: The alpha angle of the ipsilateral hip was assessed in 41 subjects with non-contact ACL tear and compared with 39 subjects with no tear. The external and internal rotation of the ipsilateral hip was also evaluated...
April 20, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28428951/the-effect-of-flour-from-the-rind-of-the-yellow-passion-fruit-on-glycemic-control-of-people-with-diabetes-mellitus-type-2-a-randomized-clinical-trial
#12
Márcio Flávio Moura de Araújo, Vivian Saraiva Veras, Roberto Wagner Júnior Freire de Freitas, Maria do Livramento de Paula, Thiago Moura de Araújo, Lilian Raquel Alexandre Uchôa, Maria Wendiane Gueiros Gaspar, Maria da Conceição do Santos Oliveira Cunha, Maria Aparecida Alves de Oliveira Serra, Carolina Maria de Lima Carvalho, Edmara Chaves Costa, Marta Maria Coelho Damasceno
BACKGROUND: The single or combined use of herbal and dietary products with medications has shown benefits in the metabolic modulation of carbohydrates, in the restoring of the function of pancreatic beta cells, and in insulin resistance. To analyze the effect of the use of flour made from the rind of the yellow passion fruit on the glycemic control of people with diabetes mellitus type 2. METHODS: An open, prospective, randomized clinical trial was undertaken with 54 participants over an eight-week period...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28428852/stoichiometric-traits-of-stickleback-effects-of-genetic-background-rearing-environment-and-ontogeny
#13
Miguel Costa Leal, Rebecca J Best, Dan Durston, Rana W El-Sabaawi, Blake Matthews
Phenotypes can both evolve in response to, and affect, ecosystem change, but few examples of diverging ecosystem-effect traits have been investigated. Bony armor traits of fish are good candidates for this because they evolve rapidly in some freshwater fish populations, and bone is phosphorus rich and likely to affect nutrient recycling in aquatic ecosystems. Here, we explore how ontogeny, rearing environment, and bone allocation among body parts affect the stoichiometric phenotype (i.e., stoichiometric composition of bodies and excretion) of threespine stickleback...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28428301/whole-genome-sequence-of-corynebacterium-pseudotuberculosis-pa04-isolated-from-the-lymph-node-of-a-sheep-in-the-amazon-brazil
#14
Wana L O Costa, Jorianne T C Alves, Larissa M Dias, Carlos Leonardo de Aragão Araújo, Eziquiel Morais, André G M Silva, Soraya S Andrade, Rommel T J Ramos, Artur Silva, Adriana R C Folador
This study reports the complete genome sequence of Corynebacterium pseudotuberculosis strain PA04, isolated from a sheep in the Amazon, Brazil. This bacterium is the etiological agent of caseous lymphadenitis. This genome contains 2,338,093 bp, 52.2% G+C content, and a total of 2,104 coding sequences (CDSs), 41 pseudogenes, 12 rRNAs, and 49 tRNAs.
April 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28428199/experimental-insights-on-darwin-s-cross-promotion-hypothesis-in-tristylous-purple-loosestrife-lythrum-salicaria
#15
Joana Costa, Sílvia Castro, João Loureiro, Spencer C H Barrett
PREMISE OF THE STUDY: Darwin proposed that the reciprocal arrangement of anthers and stigmas in heterostylous plants promotes cross-pollination through pollen segregation on pollinators' bodies. The floral tube in most heterostylous species constrains the feeding posture of pollinators determining the site of contact with sex organs located at different heights within a flower. Here, we evaluate Darwin's hypothesis in tristylous Lythrum salicaria, a species with a partially tubular corolla, and examine the extent to which the location of sex organs within a flower influence compatible and incompatible pollination...
April 20, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28428014/concussion-induces-focal-and-widespread-neuromorphological-changes
#16
Dafna Sussman, Leodante da Costa, Mallar M Chakravarty, Elizabeth W Pang, Margot J Taylor, Benjamin T Dunkley
Concussion induces transient, and oftentimes chronic, lingering impairment to mental functioning, which must be driven by some underlying neurobiological perturbation - however, the physical changes related to sequelae are difficult to detect. Previous imaging studies on concussion have focused on alterations to cortical anatomy, but few have examined the cerebrum, subcortex, and cerebellum. Here, we present an analysis of these structures in a single cohort (all males, 21 patients, 22 controls) using MRI and diagnosed with a single-concussive episode in the acute and sub-acute stages of injury...
April 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28427965/t1-st2-deficient-mice-display-protection-against-leishmania-infantum-experimental-infection
#17
Khalid Eltahir Khalid, Manuela Sales, Laís Sacramento, Diego L Costa, Djalma de Souza, Vanessa Carregaro, Joao Santana da Silva
T1/ST2 is a surface marker selectively expressed on type 2 helper (TH2) effector cells. As Leishmania infection in susceptible BALB/c mice have ascribed to a polarized TH2 response, this study aim to investigate the T1/ST2 (the receptor for IL-33), as a typical TH2 marker in the postulation that a shift towards a beneficial TH1 response would occur in the absence of ST2. For this, ST2 knockout (ST2(-/-)) and WT BALB/c mice were experimentally infected in the retro-orbital sinus with L. infantum. We showed that ST2(-/-) animals displayed better control of parasite burden in both spleen and liver tissues at different time points of chronic phases, and reduced spleenomegaly and hepatomegaly compared with the wild-type (WT) mice...
April 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28427962/first-report-of-a-rickettsia-asembonensis-related-infecting-fleas-in-brazil
#18
Arannadia Barbosa Silva, Vinicius Figueiredo Vizzoni, Andréa Pereira Costa, Francisco Borges Costa, Jonas Moraes-Filho, Marcelo Bahia Labruna, Gilberto Salles Gazêta, Rita de Maria Seabra Nogueira
The present study was performed in a non-endemic area for spotted fever (SF) in Imperatriz microregion, state of Maranhão, Brazil. Blood samples and ectoparasites were collected from 300 dogs of the Imperatriz microregion. Canine serum samples were tested individually by indirect immunofluorescence assay (IFA), using five Rickettsia isolates from Brazil. Antibodies reactive to at least one of the five species of Rickettsia were detected in 1.6% of the dogs (5/300). These sera were considered reactive to Rickettsia rickettsii and Rickettsia amblyommatis or very closely related species...
April 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28427723/health-related-quality-of-life-in-renal-transplantation-2-years-of-longitudinal-follow-up
#19
Gema Costa-Requena, M Carmen Cantarell, Francesc Moreso, Gemma Parramon, Daniel Seron
BACKGROUND AND OBJECTIVE: Health related quality of life (HRQoL) is recognized as an outcome measure in kidney transplantation. In this study was assessed changes on HRQoL and kidney-specific symptoms, also was evaluated the effect of socio-demographic and clinical parameters on patient's perceived HRQoL. PATIENTS AND METHOD: A longitudinal study was done, at 5 time-points over 2 years after transplantation. To evaluate HRQoL the Kidney Disease Quality of Life Questionnaire Short Form was administrated, and Hospital Anxiety and Depression Scale was used to assess psychological distress...
April 17, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28427691/spastic-paretic-hemifacial-contracture-as-a-presenting-feature-of-multiple-sclerosis
#20
Georgios Koutsis, Marianthi Breza, Maria-Eleftheria Evangelopoulos, Maria Anagnostouli, Elisavet Andreadou, Georgios Karagiorgis, Panagiotis Kokotis, Costas Kilidireas, Nikolaos Karandreas
BACKGROUND: Spastic paretic hemifacial contracture (SPHC) is characterized by sustained unilateral contraction of the facial muscles associated with mild ipsilateral facial paresis. Rarely described in the context of multiple sclerosis (MS), it has never been reported as presenting symptom of MS. CASE REPORTS: Two patients developed SPHC within the context of a clinically isolated syndrome suggestive of MS. EMG revealed continuous resting activity of irregularly firing motor unit potentials, associated with impaired recruitment upon voluntary contraction...
April 2017: Multiple Sclerosis and related Disorders
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