keyword
MENU ▼
Read by QxMD icon Read
search

Striatum AND dendrites

keyword
https://www.readbyqxmd.com/read/29123477/the-effects-of-medium-spiny-neuron-morphologcial-changes-on-basal-ganglia-network-under-external-electric-field-a-computational-modeling-study
#1
Xiaohan Zhang, Shenquan Liu, Feibiao Zhan, Jing Wang, Xiaofang Jiang
The damage of dopaminergic neurons that innervate the striatum has been considered to be the proximate cause of Parkinson's disease (PD). In the dopamine-denervated state, the loss of dendritic spines and the decrease of dendritic length may prevent medium spiny neuron (MSN) from receiving too much excitatory stimuli from the cortex, thereby reducing the symptom of Parkinson's disease. However, the reduction in dendritic spine density obtained by different experiments is significantly different. We developed a biological-based network computational model to quantify the effect of dendritic spine loss and dendrites tree degeneration on basal ganglia (BG) signal regulation...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29115990/dhcr24-exerts-neuroprotection-upon-inflammation-induced-neuronal-death
#2
Henna Martiskainen, Kaisa M A Paldanius, Teemu Natunen, Mari Takalo, Mikael Marttinen, Stina Leskelä, Nadine Huber, Petra Mäkinen, Enni Bertling, Hiramani Dhungana, Mikko Huuskonen, Paavo Honkakoski, Pirta Hotulainen, Kirsi Rilla, Jari Koistinaho, Hilkka Soininen, Tarja Malm, Annakaisa Haapasalo, Mikko Hiltunen
BACKGROUND: DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain areas in Alzheimer's disease. METHODS: Here, we investigated whether the overexpression of DHCR24 protects neurons against inflammation-induced neuronal death using co-cultures of mouse embryonic primary cortical neurons and BV2 microglial cells upon acute neuroinflammation...
November 7, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29043558/enriched-expression-of-neutral-sphingomyelinase-2-in-the-striatum-is-essential-for-regulation-of-lipid-raft-content-and-motor-coordination
#3
Laura Hui-Ru Tan, Angela Jin-Rong Tan, Yu-Ying Ng, John Jia-En Chua, Wee-Siong Chew, Sneha Muralidharan, Federico Torta, Bamaprasad Dutta, Siu Kwan Sze, Deron R Herr, Wei-Yi Ong
Sphingomyelinases are a family of enzymes that hydrolyze sphingomyelin to generate phosphocholine and ceramide. The brain distribution and function of neutral sphingomyelinase 2 (nSMase2) were elucidated in this study. nSMase2 mRNA expression was greatest in the striatum, followed by the prefrontal cortex, hippocampus, cerebellum, thalamus, brainstem, and olfactory bulb. The striatum had the highest level of nSMase2 protein expression, followed by the prefrontal cortex, thalamus, hippocampus, brainstem, and cerebellum...
October 17, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29027032/cocaine-increases-dopaminergic-connectivity-in-the-nucleus-accumbens
#4
Marc Dos Santos, Emma N Cahill, Gregory Dal Bo, Peter Vanhoutte, Jocelyne Caboche, Bruno Giros, Nicolas Heck
The development of addictive behavior is associated with functional and structural plasticity in the mesocorticolimbic pathway. Increased connectivity upon cocaine administration has been inferred from increases in dendritic spine density, but without observations of presynaptic elements. Recently, we established a method that enables analyses of both dendritic spines and glutamatergic boutons and presented evidence that cocaine induces changes in striatal connectivity. As the pharmacological and behavioral effects of cocaine directly implicate dopaminergic neurons and their afferents, a remaining question is whether dopaminergic striatal innervations also undergo structural plasticity...
October 12, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28831734/interactions-of-hallucinogens-with-the-glutamatergic-system-permissive-network-effects-mediated-through-cortical-layer-v-pyramidal-neurons
#5
Gerard J Marek
Recordings made from layer V (L5) pyramidal cells of the prefrontal cortex (PFC) and neocortex in rodent slice preparations have shown that serotonin (5-hydroxytryptamine, 5-HT) and serotonergic hallucinogens induce an increase in the frequency of spontaneous excitatory postsynaptic currents (EPSCs) in the apical dendritic field by activating 5-HT2A receptors. Serotonergic hallucinogens induce late EPSCs and increase recurrent network activity when subcortical or mid-cortical regions are stimulated at low frequencies (e...
August 23, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28802898/neurochemical-evidence-that-cocaine-and-amphetamine-regulated-transcript-cart-55-102-peptide-modulates-the-dopaminergic-reward-system-by-decreasing-the-dopamine-release-in-the-mouse-nucleus-accumbens
#6
Angelina Rakovska, Maria Baranyi, Katalin Windisch, Polina Petkova-Kirova, Hristo Gagov, Reni Kalfin
CART (Cocaine- and Amphetamine-Regulated Transcript) peptide is a neurotransmitter naturally occurring in the CNS and found mostly in nucleus accumbens, ventrotegmental area, ventral pallidum, amygdalae and striatum, brain regions associated with drug addiction. In the nucleus accumbens, known for its significant role in motivation, pleasure, reward and reinforcement learning, CART peptide inhibits cocaine and amphetamine-induced dopamine-mediated increases in locomotor activity and behavior, suggesting a CART peptide interaction with the dopaminergic system...
August 9, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28798977/risperidone-and-aripiprazole-alleviate-prenatal-valproic-acid-induced-abnormalities-in-behaviors-and-dendritic-spine-density-in-mice
#7
Yuta Hara, Yukio Ago, Atsuki Taruta, Shigeru Hasebe, Haruki Kawase, Wataru Tanabe, Shinji Tsukada, Takanobu Nakazawa, Hitoshi Hashimoto, Toshio Matsuda, Kazuhiro Takuma
RATIONALE: Rodents exposed prenatally to valproic acid (VPA) exhibit autism spectrum disorder (ASD)-like behavioral abnormalities. We recently found that prenatal VPA exposure causes hypofunction of the prefrontal dopaminergic system in mice. This suggests that the dopaminergic system may be a potential pharmacological target for treatment of behavioral abnormalities in ASD patients. OBJECTIVES: In the present study, we examined the effects of antipsychotic drugs, which affect the dopaminergic system, on the social interaction deficits, recognition memory impairment, and reduction in dendritic spine density in the VPA mouse model of ASD...
November 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28733355/erk-mapk-signaling-is-required-for-pathway-specific-striatal-motor-functions
#8
Scott R Hutton, James M Otis, Erin M Kim, Yashna Lamsal, Garret D Stuber, William D Snider
The ERK/MAPK intracellular signaling pathway is hypothesized to be a key regulator of striatal activity via modulation of synaptic plasticity and gene transcription. However, prior investigations into striatal ERK/MAPK functions have yielded conflicting results. Further, these studies have not delineated the cell-type-specific roles of ERK/MAPK signaling due to the reliance on globally administered pharmacological ERK/MAPK inhibitors and the use of genetic models that only partially reduce total ERK/MAPK activity...
August 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28634551/mechanisms-and-consequences-of-dopamine-depletion-induced-attenuation-of-the-spinophilin-neurofilament-medium-interaction
#9
Andrew C Hiday, Michael C Edler, Asma B Salek, Cameron W Morris, Morrent Thang, Tyler J Rentz, Kristie L Rose, Lisa M Jones, Anthony J Baucum
Signaling changes that occur in the striatum following the loss of dopamine neurons in the Parkinson disease (PD) are poorly understood. While increases in the activity of kinases and decreases in the activity of phosphatases have been observed, the specific consequences of these changes are less well understood. Phosphatases, such as protein phosphatase 1 (PP1), are highly promiscuous and obtain substrate selectivity via targeting proteins. Spinophilin is the major PP1-targeting protein enriched in the postsynaptic density of striatal dendritic spines...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28633952/chronic-methylphenidate-regulates-genes-and-proteins-mediating-neuroplasticity-in-the-juvenile-rat-brain
#10
Emmanuel Quansah, Tiziana Sgamma, Estabraq Jaddoa, Tyra S C Zetterström
Methylphenidate (MPH) is the front-line psychostimulant medication prescribed for alleviating the symptoms associated with attention deficit hyperactivity disorder (ADHD) in children. Here, we investigated the effects of chronic MPH (2.0mg/kg, twice daily for 15days) exposure to young rats (20-25days old at start of treatment) on the expression of genes and proteins associated with neuroplasticity, such as activity regulated cytoskeleton-associated protein (Arc), insulin receptor substrate protein 53 (IRSp53), cell division control protein 42 (Cdc42), and actin-related protein 2 (Arp2)...
June 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28578004/alterations-of-striatal-indirect-pathway-neurons-precede-motor-deficits-in-two-mouse-models-of-huntington-s-disease
#11
Irene Sebastianutto, Maria Angela Cenci, Tim Fieblinger
Striatal neurons forming the indirect pathway (iSPNs) are particularly vulnerable in Huntington's disease (HD). In this study we set out to investigate morphological and physiological alterations of iSPNs in two mouse models of HD with relatively slow disease progression (long CAG repeat R6/2 and zQ175-KI). Both were crossed with a transgenic mouse line expressing eGFP in iSPNs. Using the open-field and rotarod tests, we first defined two time points in relation to the occurrence of motor deficits in each model...
September 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28576726/nicotine-induced-and-d1-receptor-dependent-dendritic-remodeling-in-a-subset-of-dorsolateral-striatum-medium-spiny-neurons
#12
Daniel G Ehlinger, Julian C Burke, Craig G McDonald, Robert F Smith, Hadley C Bergstrom
Nicotine is one of the most addictive substances known, targeting multiple memory systems, including the ventral and dorsal striatum. One form of neuroplasticity commonly associated with nicotine is dendrite remodeling. Nicotine-induced dendritic remodeling of ventral striatal medium spiny neurons (MSNs) is well-documented. Whether MSN dendrites in the dorsal striatum undergo a similar pattern of nicotine-induced structural remodeling is unknown. A morphometric analysis of Golgi-stained MSNs in rat revealed a natural asymmetry in dendritic morphology across the mediolateral axis, with larger, more complex MSNs found in the dorsolateral striatum (DLS)...
May 31, 2017: Neuroscience
https://www.readbyqxmd.com/read/28503136/a-quantitative-golgi-study-of-dendritic-morphology-in-the-mice-striatal-medium-spiny-neurons
#13
Ivana Bicanic, Ana Hladnik, Zdravko Petanjek
In this study we have provided a detailed quantitative morphological analysis of medium spiny neurons (MSNs) in the mice dorsal striatum and determined the consistency of values among three groups of animals obtained in different set of experiments. Dendritic trees of 162 Golgi Cox (FD Rapid GolgiStain Kit) impregnated MSNs from 15 adult C57BL/6 mice were 3-dimensionally reconstructed using Neurolucida software, and parameters of dendritic morphology have been compared among experimental groups. The parameters of length and branching pattern did not show statistically significant difference and were highly consistent among groups...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28473642/selective-vulnerability-of-striatal-d2-versus-d1-dopamine-receptor-expressing-medium-spiny-neurons-in-hiv-1-tat-transgenic-male-mice
#14
Christina J Schier, William D Marks, Jason J Paris, Aaron J Barbour, Virginia D McLane, William F Maragos, A Rory McQuiston, Pamela E Knapp, Kurt F Hauser
Despite marked regional differences in HIV susceptibility within the CNS, there has been surprisingly little exploration into the differential vulnerability among neuron types and the circuits they underlie. The dorsal striatum is especially susceptible, harboring high viral loads and displaying marked neuropathology, with motor impairment a frequent manifestation of chronic infection. However, little is known about the response of individual striatal neuron types to HIV or how this disrupts function. Therefore, we investigated the morphological and electrophysiological effects of HIV-1 trans-activator of transcription (Tat) in dopamine subtype 1 (D1) and dopamine subtype 2 (D2) receptor-expressing striatal medium spiny neurons (MSNs) by breeding transgenic Tat-expressing mice to Drd1a-tdTomato- or Drd2-eGFP-reporter mice...
June 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28469074/sorcs2-mediated-nr2a-trafficking-regulates-motor-deficits-in-huntington-s-disease
#15
Qian Ma, Jianmin Yang, Teresa A Milner, Jean-Paul G Vonsattel, Mary Ellen Palko, Lino Tessarollo, Barbara L Hempstead
Motor dysfunction is a prominent and disabling feature of Huntington's disease (HD), but the molecular mechanisms that dictate its onset and progression are unknown. The N-methyl-D-aspartate receptor 2A (NR2A) subunit regulates motor skill development and synaptic plasticity in medium spiny neurons (MSNs) of the striatum, cells that are most severely impacted by HD. Here, we document reduced NR2A receptor subunits on the dendritic membranes and at the synapses of MSNs in zQ175 mice that model HD. We identify that SorCS2, a vacuolar protein sorting 10 protein-domain (VPS10P-domain) receptor, interacts with VPS35, a core component of retromer, thereby regulating surface trafficking of NR2A in MSNs...
May 4, 2017: JCI Insight
https://www.readbyqxmd.com/read/28462043/lack-of-riluzole-efficacy-in-the-progression-of-the-neurodegenerative-phenotype-in-a-new-conditional-mouse-model-of-striatal-degeneration
#16
Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Piotr Chmielarz, Monika Bagińska, Irena Nalepa
BACKGROUND: Huntington's disease (HD) is a rare familial autosomal dominant neurodegenerative disorder characterized by progressive degeneration of medium spiny neurons (MSNs) located in the striatum. Currently available treatments of HD are only limited to alleviating symptoms; therefore, high expectations for an effective therapy are associated with potential replacement of lost neurons through stimulation of postnatal neurogenesis. One of the drugs of potential interest for the treatment of HD is riluzole, which may act as a positive modulator of adult neurogenesis, promoting replacement of damaged MSNs...
2017: PeerJ
https://www.readbyqxmd.com/read/28414299/an-indirect-route-to-repetitive-actions
#17
David M Lovinger
It is increasingly evident that there is a genetic contribution to autism spectrum disorders (ASDs) and other neural disorders involving excessive repetition of action sequences. Among the implicated genes in these disorders are those encoding postsynaptic scaffolding proteins with roles in synaptic transmission and plasticity. Several mouse models harboring synonymous mutations have shown alterations in synaptic transmission within the striatum, which has key roles in controlling actions and action sequences...
May 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28363668/methylphenidate-alleviates-manganese-induced-impulsivity-but-not-distractibility
#18
Stephane A Beaudin, Barbara J Strupp, Walter Uribe, Lauren Ysais, Myla Strawderman, Donald R Smith
Recent studies from our lab have demonstrated that postnatal manganese (Mn) exposure in a rodent model can cause lasting impairments in fine motor control and attention, and that oral methylphenidate (MPH) treatment can effectively treat the dysfunction in fine motor control. However, it is unknown whether MPH treatment can alleviate the impairments in attention produced by Mn exposure. Here we used a rodent model of postnatal Mn exposure to determine whether (1) oral MPH alleviates attention and impulse control deficits caused by postnatal Mn exposure, using attention tasks that are variants of the 5-choice serial reaction time task, and (2) whether these treatments affected neuronal dendritic spine density in the medial prefrontal cortex (mPFC) and dorsal striatum...
May 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28345671/spatiotemporal-expression-of-osteopontin-in-the-striatum-of-rats-subjected-to-the-mitochondrial-toxin-3-nitropropionic-acid-correlates-with-microcalcification
#19
Tae-Ryong Riew, Hong Lim Kim, Xuyan Jin, Jeong-Heon Choi, Yoo-Jin Shin, Ji Soo Kim, Mun-Yong Lee
Our aim was to elucidate whether osteopontin (OPN) is involved in the onset of mineralisation and progression of extracellular calcification in striatal lesions due to mitochondrial toxin 3-nitropropionic acid exposure. OPN expression had two different patterns when observed using light microscopy. It was either localised to the Golgi complex in brain macrophages or had a small granular pattern scattered in the affected striatum. OPN labelling tended to increase in number and size over a 2-week period following the lesion...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28343296/ibuprofen-protects-from-cypermethrin-induced-changes-in-the-striatal-dendritic-length-and-spine-density
#20
Pratibha Tripathi, Ashish Singh, Lakshmi Bala, Devendra Kumar Patel, Mahendra Pratap Singh
Microgliosis and inflammation are major wrongdoers in cypermethrin-induced Parkinsonism along with oxidative stress, mitochondrial dysfunction and α-synuclein aggregation. Dopamine depletion could alter dendritic morphology, length and spine number in the striatum. Present study investigated the effect of ibuprofen on the dendritic morphology, length and spine density in cypermethrin PD model. Male pups were treated intraperitoneally with cypermethrin during postnatal days followed by adulthood to induce Parkinsonism using standard procedure along with controls...
March 25, 2017: Molecular Neurobiology
keyword
keyword
85764
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"