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https://www.readbyqxmd.com/read/29151238/predictability-of-hypoadrenalism-occurrence-and-duration-after-adrenalectomy-for-acth-independent-hypercortisolism
#1
V Morelli, L Minelli, C Eller-Vainicher, S Palmieri, E Cairoli, A Spada, M Arosio, I Chiodini
OBJECTIVE: To evaluate if the parameters of hypothalamic-pituitary-adrenal (HPA) axis activity could predict the occurrence and duration of post-surgical hypocortisolism (PSH) in patients with Cushing's syndrome (CS) and with adrenal incidentaloma (AI). METHODS: We studied 80 patients (54 females, age 53.3 ± 11 years), who underwent adrenalectomy for CS (17 patients) or for AI (53 patients). Before surgery, we measured adrenocorticotroph hormone (ACTH), urinary free cortisol (UFC) and serum cortisol after 1 mg dexamethasone suppression test (1 mg-DST) levels...
November 18, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29147959/port-site-hernia-after-laparoscopic-sleeve-gastrectomy-a-retrospective-cohort-study-of-352-patients
#2
Ilhan Ece, Huseyin Yilmaz, Husnu Alptekin, Serdar Yormaz, Bayram Colak, Mustafa Sahin
Port site hernia (PSH) following laparoscopic procedures is a rare but serious complication. The aim of this study was to evaluate the rate of PSH after laparoscopic sleeve gastrectomy (LSG), and the efficacy of closure of the port site as a means of preventing PSH. A retrospective analysis was performed on 386 patients who underwent LSG between December 2009 and January 2015. 352 (91.2%) of the patient were followed up for at least 24 months. In the first 206 patients, the fascial layers of the trocar incisions were not closed, while in the next 146 cases, routine closure of the trocar sites was performed...
November 16, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/29112196/understanding-the-roles-of-mutations-in-the-amyloid-precursor-protein-in-alzheimer-disease
#3
REVIEW
S Hunter, C Brayne
Many models of disease progression in Alzheimer's disease (AD) have been proposed to help guide experimental design and aid the interpretation of results. Models focussing on the genetic evidence include the amyloid cascade (ACH) and presenilin (PSH) hypotheses and the amyloid precursor protein (APP) matrix approach (AMA), of which the ACH has held a dominant position for over two decades. However, the ACH has never been fully accepted and has not yet delivered on its therapeutic promise. We review the ACH, PSH and AMA in relation to levels of APP proteolytic fragments reported from AD-associated mutations in APP...
November 7, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29112167/overexpression-of-a-new-chitinase-gene-euchit2-enhances-resistance-to-erysiphe-cichoracearum-dc-in-tobacco-plants
#4
Xuan Dong, Yichen Zhao, Xin Ran, Linxia Guo, De-Gang Zhao
In this study, we cloned a new chitinase gene, EuCHIT2, from Eucommia ulmoides Oliver (E. ulmoides) using rapid amplification of cDNA ends (RACE) technology and constructed an overexpression vector, pSH-35S-EuCHIT2, to introduce it into tobacco (Nicotiana tabacum cv. Xanthi). Resistance to Erysiphe cichoracearum de Candolle (E.cichoracearum DC) and molecular mechanisms in the transgenic tobacco were determined by drop inoculation, spore counting, determination of physicochemical indicators, and analysis of gene expression...
November 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29064900/use-of-prophylactic-mesh-when-creating-a-colostomy-does-not-prevent-parastomal-hernia-a-randomized-controlled-trial-stomamesh
#5
Christoffer Odensten, Karin Strigård, Jörgen Rutegård, Michael Dahlberg, Ulrika Ståhle, Ulf Gunnarsson, Pia Näsvall
OBJECTIVE: The aim of this study was to determine whether parastomal hernia (PSH) rate can be reduced by using synthetic mesh in the sublay position when constructing permanent end colostomy. The secondary aim was to investigate possible side-effects of the mesh. BACKGROUND: Prevention of PSH is important as it often causes discomfort and leakage from stoma dressing. Different methods of prevention have been tried, including several mesh techniques. The incidence of PSH is high; up to 78%...
October 23, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29052472/extraction-and-reliable-determination-of-acrylamide-from-thermally-processed-foods-using-ionic-liquid-based-ultrasound-assisted-selective-microextraction-combined-with-spectrophotometry
#6
Nail Altunay, Adil Elik, Ramazan Gürkan
Acrylamide (AAm) is a carcinogenic chemical that can form in thermally processed foods by the Maillard reaction of glucose with asparagine. AAm can easily be formed especially in frequently consumed chips and cereal-based foods depending on processing conditions. Considering these properties of AAm, a new, simple and green method is proposed for the extraction of AAm from thermally processed food samples. In this study, an ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate, [Bmim][BF4]) as extractant was used in the presence of a cationic phenazine group dye, 3,7-diamino-5-phenylphenazinium chloride (PSH(+), phenosafranine) at pH 7...
October 31, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29032372/parenchymal-sparing-surgery-for-the-surgical-treatment-of-multiple-colorectal-liver-metastases-is-a-safer-approach-than-major-hepatectomy-not-impairing-patients-prognosis-a-bi-institutional-propensity-score-matched-analysis
#7
Matteo Donadon, Matteo Cescon, Alessandro Cucchetti, Matteo Cimino, Guido Costa, Benedetta Pesi, Giorgio Ercolani, Antonio Daniele Pinna, Guido Torzilli
BACKGROUND: The performance of parenchymal-sparing hepatectomy (PSH) versus major hepatectomy (MH) in patients with multiple colorectal liver metastases (CLM) is a matter that is yet debated. We investigated the outcome of patients with multiple CLM undergoing PSH instead of MH. METHODS: Databases at 2 institutions were reviewed. A propensity score-matched analysis was applied. Among 554 patients, 110 undergoing PSH and 110 undergoing MH were matched. They were similar in baseline characteristics, comorbidity, and tumor features...
October 14, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29028454/the-longtan-modification-an-effective-and-economical-surgical-innovation-for-parastomal-hernia-post-intraperitoneal-sigmoidostomy
#8
Peng Wang, Hao Su, Jianwei Liang, Zheng Wang, Zhixiang Zhou, Haitao Zhou
PURPOSE: This study was designed to introduce a new surgical innovation, referred to as the "Longtan modification," for cases with parastomal hernia (PSH) following intraperitoneal sigmoidostomy, and to assess the safety and feasibility of this procedure. METHODS: Between January 2013 and June 2016, a total of 26 consecutive cases with PSH successfully underwent this procedure. The patient demographics, surgical outcomes, stoma-related complications, and the stoma function were collected and analyzed...
October 13, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28984074/availability-of-comprehensive-services-in-permanent-supportive-housing-in-los-angeles
#9
Benjamin F Henwood, Taylor Harris, Darlene Woo, Hailey Winetrobe, Harmony Rhoades, Suzanne L Wenzel
Studies have often described a specific model or models of permanent supportive housing (PSH), yet few studies have systematically examined what services are typically offered to PSH tenants in any given service system and how those services are offered. Using telephone surveys from 23 PSH agency supervisors and qualitative data collected from 11 focus groups with 60 frontline providers and 17 individual interviews with supervisors from a subset of surveyed agencies-all of which were completed between July 2014 and December 2015-the goal of this study is to better understand what services are being offered in PSH organisations located in Los Angeles and what barriers frontline providers face in delivering these services...
October 6, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28978176/dexmedetomidine-attenuates-acute-paroxysmal-sympathetic-hyperactivity
#10
Yuan Peng, Haifeng Zhu, Haodong Chen, Zijin Zhu, Huahai Zhou, Shuguang Zhang, Lili Gao, Lei Shi, Xiaoliang Li, Zhengxiang Luo
We evaluated the curative effect of dexmedetomidine on paroxysmal sympathetic hyperactivity (PSH) in a retrospective study of 72 PSH patients after neurosurgery. Our results showed that dexmedetomidine was superior to propofol for treatment of PSH with respect to: average time needed to reduce paroxysmal hypertension (PH) to <140/90 mmHg (29.03±8.86 vs. 42.0±14.77 min), average remission time of PH (3.97±1.73 vs. 5.65±1.51 min), PH remission rate (61.22±10.8% vs. 41.52±14.15%), PH duration (9.31±2...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28964298/implementation-of-a-perioperative-surgical-home-protocol-for-pediatric-patients-presenting-for-adenoidectomy
#11
Vidya T Raman, Dmitry Tumin, Joshua Uffman, Arlyne K Thung, Candice Burrier, Kris R Jatana, Charles Elmaraghy, Joseph D Tobias
INTRODUCTION: The perioperative surgical home (PSH) is a patient-centered model designed to improve health, streamline the delivery of health care, and reduce the cost of care. Following the national introduction of PSH in 2014 by the ASA, adult hospitals have reported success with this model, with studies validating the benefits of PSH including reducing length of stay, lowering costs, and improving patient satisfaction. METHODS: Eligible patients, ranging in age from 16-35 months of age, were identified by the pre-admission testing (PAT) registered nurses (RNs) and faculty anesthesiologists upon review of the patient history...
October 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28913487/perioperative-surgical-home-meeting-tomorrow-s-challenges
#12
REVIEW
Teodora O Nicolescu
New healthcare models pose a variety of changes for anesthesiologists, ranging from the need to improve quality and to cost containment: as such, the concept of Perioperative Surgical Home (PSH) has been developed. Modelled after the UK's Enhanced Recovery After Surgery (ERAS), PSH takes a step further by coordinating care starting from the time a surgical decision is made for the patient to as many as 30 days postoperatively, taking a logical evidenced-based approach to judicious preoperative testing. Perioperative surgical home also relies heavily on engineering imported strategies such as the use of Lean Six Sigma methodologies, and involves active participation of all stakeholders...
October 2016: Rom J Anaesth Intensive Care
https://www.readbyqxmd.com/read/28912489/incoherent-digital-holograms-acquired-by-interferenceless-coded-aperture-correlation-holography-system-without-refractive-lenses
#13
Manoj Kumar, A Vijayakumar, Joseph Rosen
We present a lensless, interferenceless incoherent digital holography technique based on the principle of coded aperture correlation holography. The acquired digital hologram by this technique contains a three-dimensional image of some observed scene. Light diffracted by a point object (pinhole) is modulated using a random-like coded phase mask (CPM) and the intensity pattern is recorded and composed as a point spread hologram (PSH). A library of PSHs is created using the same CPM by moving the pinhole to all possible axial locations...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28890524/diagnosis-and-management-of-patients-with-paroxysmal-sympathetic-hyperactivity-following-acute-brain-injuries-using-a-consensus-based-diagnostic-tool-a-single-institutional-case-series
#14
Shigeo Godo, Shigemi Irino, Atsuhiro Nakagawa, Yu Kawazoe, Motoo Fujita, Daisuke Kudo, Ryosuke Nomura, Hiroaki Shimokawa, Shigeki Kushimoto
Paroxysmal sympathetic hyperactivity (PSH) is a distinct syndrome of episodic sympathetic hyperactivities following severe acquired brain injury, characterized by paroxysmal transient fever, tachycardia, hypertension, tachypnea, excessive diaphoresis and specific posturing. PSH remains to be an under-recognized condition with a diagnostic pitfall especially in the intensive care unit (ICU) settings due to the high prevalence of concomitant diseases that mimic PSH. A consensus set of diagnostic criteria named PSH-Assessment Measure (PSH-AM) has been developed recently, which is consisted of two components: a diagnosis likelihood tool derived from clinical characteristics of PSH, and a clinical feature scale assigned to the severity of each sympathetic hyperactivity...
September 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28890392/natural-history-and-predictors-of-parastomal-hernia-after-robot-assisted-radical-cystectomy-and-ileal-conduit-urinary-diversion
#15
Ahmed A Hussein, Youssef E Ahmed, Paul May, Taimoor Ali, Basim Ahmad, Sana Raheem, Kevin Stone, Adam Hasasnah, Omer Rana, Adam Cole, Derek Wang, Peter Loud, Khurshid A Guru
INTRODUCTION: We investigated the prevalence, variables associated with parastomal hernia (PSH), and its outcomes of after robot-assisted radical cystectomy (RARC) and ileal conduit (IC) for bladder cancer. METHODS: Retrospective review of RARC at our institution was conducted. PSH was defined as protrusion of abdominal contents through the stoma defect in the abdominal wall on cross sectional imaging. PSH was further described in terms of patient and hernia characteristics, symptoms, management and outcomes...
September 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28884243/smoking-policy-change-within-permanent-supportive-housing
#16
Anne Berit Petersen, Holly C Stewart, Jon Walters, Maya Vijayaraghavan
Smoke-free policies effectively reduce secondhand smoke (SHS) exposure among non-smokers, and reduce consumption, encourage quit attempts, and minimize relapse to smoking among smokers. Such policies are uncommon in permanent supportive housing (PSH) for formerly homeless individuals. In this study, we collaborated with a PSH provider in San Diego, California to assess a smoke-free policy that restricted indoor smoking. Between August and November 2015, residents completed a pre-policy questionnaire on attitudes toward smoke-free policies and exposure to secondhand smoke, and then 7-9 months after policy implementation residents were re-surveyed...
September 7, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28875330/liposomes-co-loaded-with-6-phosphofructo-2-kinase-fructose-2-6-biphosphatase-3-pfkfb3-shrna-plasmid-and-docetaxel-for-the-treatment-of-non-small-cell-lung-cancer
#17
Nusrat Chowdhury, Imran Vhora, Ketan Patel, Ravi Doddapaneni, Arindam Mondal, Mandip Singh
PURPOSE: Non-small cell lung cancer is the leading cause of cancer related deaths globally. Considering the side effects and diminishing chemosensitivity to chemotherapy, novel treatment approaches are sought. Hence, we aim to develop a liposomal co-delivery system of pDNA expressing shRNA against PFKFB3 (pshPFKFB3) and docetaxel (DTX). METHODS: Cationic DTX liposomes complexed with pshPFKFB3 (PSH-DL) were developed. In vitro cell line studies were performed to evaluate transfection, PFKFB3 mRNA silencing, cytotoxicity, pGP inhibition, and protein markers expression...
November 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28860930/new-human-single-chain-anti-idiotypic-antibody-against-benzo-a-pyrene
#18
Artem E Studennikov, Valentin A Ustinov, Vera V Morozova, Nina V Tikunova, Andrey N Glushkov
The nal¨ve library from the lymphocytes of healthy humans was screened by murine single-stranded idiotypic antibodies against benzo[a]pyrene (pSh). The phage clone which contained of anti-idiotypic antibody against benzo[a]pyrene, designated as A4, was chosen for further work because of highly specific to pSh. The available protein databases were searched. The A4 amino acid sequence was unique and 76% identical to a sequence in antibody against interferon g. The A4 protein was expressed in bacteria and purified by two different methods: His-tagged A4 and CBD-fusion A4...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28857582/supporting-veterans-transitions-from-permanent-supportive-housing
#19
Ann Elizabeth Montgomery, Meagan C Cusack, Sonya Gabrielian
OBJECTIVES: Little research has assessed the nature of veterans' departures from permanent supportive housing (PSH), which may be of positive valence (e.g., moving into more independent housing). This study aimed to identify participants appropriate for "graduation" from PSH and how to support their transitions. METHOD: This mixed methods study used qualitative data from PSH program staff, 445 PSH participants' responses to a survey assessing their experiences and administrative records, and qualitative data from a subsample of 10 participants who graduated from the program...
August 31, 2017: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/28853044/consensus-statement-for-clinical-pathway-development-for-perioperative-pain-management-and-care-transitions
#20
REVIEW
Alan D Kaye, Erik M Helander, Nalini Vadivelu, Leandro Lumermann, Thomas Suchy, Margaret Rose, Richard D Urman
The perioperative surgical home (PSH) model has been created with the intention to reduce costs and to improve efficiency of care and patient experience in the perioperative period. The PSH is a comprehensive model of care that is team-based and patient-centric. The team in each facility should be multidisciplinary and include the input of perioperative services leadership, surgical services, and support personnel in order to provide seamless care for the patient from the preoperative period when decision to undergo surgery is initially made to discharge and, if needed after discharge from the hospital, until full recovery is achieved...
December 2017: Pain and Therapy
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