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https://www.readbyqxmd.com/read/29925099/a-systematic-review-on-promoting-adherence-to-antiretroviral-therapy-in-hiv-infected-patients-using-mobile-phone-technology
#1
Yuri Quintana, Eduardo A Gonzalez Martorell, Darren Fahy, Charles Safran
OBJECTIVE:  Adherence to antiretroviral therapy (ART) is paramount to successful long-term suppression of human immunodeficiency virus (HIV). For poorly adherent patients with HIV, barriers to remaining adherent may be overcome by the implementation of targeted interventions delivered via mobile devices. This systematic review is focused specifically on mobile phone technologies to deliver adherence interventions in HIV/acquired immunodeficiency syndrome (AIDS) populations. METHODS:  This review (PROSPERO #CRD42017065131) systematically extracted data from published literature from five databases on mobile phone interventions to improve adherence to ART for HIV...
April 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29925066/the-vasopressin-system-in-the-risk-of-diabetes-and-cardiorenal-disease-and-hydration-as-a-potential-lifestyle-intervention
#2
Sofia Enhörning, Olle Melander
BACKGROUND: Type 2 diabetes, chronic kidney disease (CKD) and its cardiovascular complications are increasing as health problems worldwide. These diseases are interrelated with overlapping occurrence and once diabetes is established, the risk of cardiorenal disease is dramatically elevated. Thus, a search for unifying modifiable risk factors is key for effective prevention. SUMMARY: Elevated fasting plasma concentration of vasopressin, measured with the marker copeptin, predicts new onset type 2 diabetes as well as renal function decline...
2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29925064/once-weekly-administration-of-sustained-release-growth-hormone-in-korean-prepubertal-children-with-idiopathic-short-stature-a-randomized-controlled-phase-ii-study
#3
Jin Soon Hwang, Hae Sang Lee, Kee-Hyoung Lee, Han-Wook Yoo, Dae-Yeol Lee, Byung-Kyu Suh, Cheol Woo Ko, Woo Yeong Chung, Dong-Kyu Jin, Choong Ho Shin, Heon-Seok Han, Song Han, Ho-Seong Kim
BACKGROUND/AIMS: To determine the optimal dose of LB03002, a sustained-release, once-weekly formulation of recombinant human growth hormone (rhGH), and to compare its efficacy and safety with daily rhGH in children with idiopathic short stature (ISS). METHODS: This multicenter, randomized, open-label, phase II study included GH-naïve, prepubertal children with ISS, randomized to receive daily rhGH 0.37 mg/kg/week (control, n = 16), LB03002 0.5 mg/kg/week (n = 14), or LB03002 0...
June 20, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29925054/influence-of-interspecific-interactions-on-avoidance-response-to-contamination
#4
Daniel C V R Silva, Cristiano V M Araújo, Rodrigo J Marassi, Sheila Cardoso-Silva, Morun B Neto, Gilmar C Silva, Rui Ribeiro, Flávio T Silva, Teresa C B Paiva, Marcelo L M Pompêo
An increasing number of studies have shown the ability of organisms to escape from toxic effects due to contamination, by moving spatially towards less contaminated habitats. However, this issue has been investigated in monospecific scenarios, without considering possible interactions between species during the contamination avoidance process. It is widely known that the spatial distribution of one species can be affected by another one, in different ways. Therefore, the main question addressed in the present study was as follows: Might interspecific interaction between the freshwater fish Danio rerio (zebrafish) and Poecilia reticulata (guppy) change their behavior patterns in terms of avoidance in the presence of a copper gradient? Zebrafish and guppies exposed to a copper gradient were tested for avoidance responses in a free-choice, non-forced, static, multi-compartmented exposure system, using two distinct approaches: (1) monospecific tests, in which only one species was exposed to the copper gradient, at two different population densities; and (2) multispecific tests, in which both species were tested simultaneously...
June 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29924907/tamoxifen-and-meglumine-antimoniate-combined-therapy-in-cutaneous-leishmaniasis-patients-a-randomized-trial
#5
Paulo R L Machado, Camila S Ribeiro, Jaqueline França-Costa, Mayra E F Dourado, Cristiana T Trinconi, Jenicer K U Yokoyama-Yasunaka, Hayna Malta-Santos, Valéria M Borges, Edgar M Carvalho, Silvia R B Uliana
OBJECTIVES: There is a clear need for new strategies of leishmaniasis treatment. This work was conducted to evaluate the efficacy of the co-administration of tamoxifen and meglumine antimoniate (SbV ) in a phase II pilot clinical trial in localized cutaneous leishmaniasis patients. METHODS: A randomized controlled pilot clinical trial was conducted to evaluate the efficacy and safety of oral (40 mg/day for 20 days) or topical tamoxifen (0.1% tamoxifen citrate for 20 days) combined with meglumine antimoniate (20 mg SbV /kg/day for 20 days) versus a standard SbV protocol (20 mg/kg/day for 20 days) for the treatment of cutaneous leishmaniasis...
June 20, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29924769/randomized-double-blind-study-comparing-percutaneous-electrolysis-and-dry-needling-for-the-management-of-temporomandibular-myofascial-pain
#6
R Lopez-Martos, L-M Gonzalez-Perez, P Ruiz-Canela-Mendez, F-J Urresti-Lopez, J-L Gutierrez-Perez, P Infante-Cossio
BACKGROUND: To assess whether the techniques of percutaneous needle electrolysis (PNE) and deep dry needling (DDN) used on trigger points (TrP) of lateral pterygoid muscle (LPM) can significantly reduce pain and improve function in patients with myofascial pain syndrome (MPS) compared to a control group treated with a sham needling procedure (SNP). MATERIAL AND METHODS: Sixty patients diagnosed with MPS in the LPM were selected and randomly assigned to one of three groups...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29924719/functional-and-patient-reported-outcomes-improve-over-the-course-of-rehabilitation-a-secondary-analysis-of-the-acl-sports-trial
#7
Amelia J H Arundale, Jacob J Capin, Ryan Zarzycki, Angela Smith, Lynn Snyder-Mackler
BACKGROUND: The Anterior Cruciate Ligament-Specialized Post-Operative Return to Sports (ACL-SPORTS) randomized controlled trial was designed to address deficits in functional and patient-reported outcomes. The trial examined the effects of a secondary ACL prevention program that included progressive strengthening, agility training, plyometrics (SAP), and other components of current primary prevention protocols, with perturbation training (SAP + PERT group) and without PERT (SAP group)...
June 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29924696/commercially-available-compression-garments-or-electrical-stimulation-do-not-enhance-recovery-following-a-sprint-competition-in-elite-cross-country-skiers
#8
Andrew David Govus, Erik Petrus Andersson, Oliver Michael Shannon, Holly Provis, Mathilda Karlsson, Kerry McGawley
This study investigated whether commercially available compression garments (COMP) exerting a moderate level of pressure and/or neuromuscular electrical stimulation (NMES) accelerate recovery following a cross-country sprint skiing competition compared with a control group (CON) consisting of active recovery only. Twenty-one senior (12 males, 9 females) and 11 junior (6 males, 5 females) Swedish national team skiers performed an outdoor sprint skiing competition involving four sprints lasting ∼3-4 min. Before the competition, skiers were matched by sex and skiing level (senior versus junior) and randomly assigned to COMP (n = 11), NMES (n = 11) or CON (n = 10)...
June 20, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29924669/treatment-of-lymphatic-malformations-with-the-mtor-inhibitor-sirolimus-a-systematic-review
#9
Susanne Wiegand, Gunnar Wichmann, Andreas Dietz
BACKGROUND: Extensive lymphatic malformations are low-flow vascular malformations that can cause devastating complications. Treatment of these malformations is challenging. This systematic review presents current use of sirolimus in patients with extensive lymphatic malformations. METHODS: MEDLINE and Google scholar search was conducted for studies on sirolimus treatment of lymphatic malformations up to July 2017. Search items included "lymphatic malformation," "lymphangioma," "cystic hygroma," "vascular malformation," "low-flow malformation," "sirolimus," "rapamycin," and "mTOR inhibitor...
June 20, 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29924641/efficacy-safety-and-acceptability-of-the-new-pen-needle-34g-%C3%A3-3-5-mm-a-cross-over-randomized-non-inferiority-trial-ago-02-study
#10
Giorgia De Berardis, Marco Scardapane, Giuseppe Lucisano, Santina Abbruzzese, Antonio Carlo Bossi, Elisa Cipponeri, Paola D'Angelo, Lucia Fontana, Roberta Lancione, Giuseppe Marelli, Luigi Sciangula, Antonio Nicolucci
OBJECTIVE: Insulin injection aspects, such as fear of injection and pain, directly affect glycemic control, patient adherence, and quality of life. Use of thinner and shorter needles could increase acceptance of injections. Aim of the study is to evaluate the non-inferiority of the new 34Gx3.5 mm needle compared to a 32GX4mm in patients with diabetes treated with insulin. METHODS: This is an open, randomized, two-period cross-over, noninferiority trial. Every treatment period lasted 3 weeks...
June 20, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29924507/relapse-after-antipsychotic-discontinuation-in-schizophrenia-as-a-withdrawal-phenomenon-vs-illness-recurrence-a-post-hoc-analysis-of-a-randomized-placebo-controlled-study
#11
Robin Emsley, Isaac Nuamah, Srihari Gopal, David Hough, W Wolfgang Fleischhacker
BACKGROUND: It has been proposed that relapse rates after antipsychotic discontinuation may be artificially inflated and that some of these symptom recurrences may be due to rebound or withdrawal phenomena rather than due to illness recurrence. METHODS: Post hoc analysis of data from a relapse-prevention study (conducted from March 2005 to February 2007) of paliperidone palmitate once-monthly (PP1M) versus placebo was conducted to compare the nature of operationally defined relapse events in schizophrenia patients (diagnosed by DSM-IV criteria) experiencing relapses after randomization to placebo (n = 97) with those in patients receiving maintenance PP1M treatment (n = 36)...
June 19, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29924461/short-term-external-counterpulsation-augments-cerebral-blood-flow-and-tissue-oxygenation-in-chronic-cerebrovascular-occlusive-disease
#12
Eva E Buschmann, Philipp Hillmeister, Anja Bondke Persson, David S Liebeskind, Lea Schlich, Robert Kamenzky, Andreas Busjahn, Ivo R Buschmann, Peter Bramlage, Andreas Hetzel, Matthias Reinhard
BACKGROUND: External counterpulsation improves cerebral perfusion velocity in acute stroke and may stimulate collateral artery growth. However, whether (non-acute) at-risk patients with high-grade carotid artery disease may benefit from counterpulsation needs to be validated. METHODS: Twenty-eight patients (71±6.5 years, 5 women) with asymptomatic unilateral chronic severe ICA stenosis (>70%) or occlusion were randomized to receive 20 min active counterpulsation followed by sham treatment or vice versa...
June 20, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29924423/methods-of-enteral-nutrition-administration-in-critically-ill-patients-continuous-intermittent-cyclic-and-bolus-feeding
#13
REVIEW
Satomi Ichimaru
There are several methods of enteral nutrition (EN) administration, including continuous, cyclic, intermittent, and bolus techniques, which can be used either alone or in combination. Continuous feeding involves hourly administration of EN over 24 hours assisted by a feeding pump; cyclic feeding involves administration of EN over a time period of <24 hours generally assisted by a feeding pump; intermittent feeding involves administration of EN over 20-60 minutes every 4-6 hours via pump assist or gravity assist; and bolus feeding involves administration of EN over a 4- to 10-minute period using a syringe or gravity drip...
June 20, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29924421/description-and-preliminary-outcomes-of-an-in-vivo-exposure-group-treatment-for-posttraumatic-stress-disorder
#14
Eliora Porter, Erin G Romero, Melissa D Barone
Prolonged exposure (PE) therapy is traditionally delivered individually to patients. To engage more veterans in care, an in vivo exposure group treatment was developed in an urban VA medical center. This treatment represented a modification of the in vivo exposure portion of PE, with the addition of in-session, therapist-assisted in vivo exposures. Here, we describe this 12-week treatment and present preliminary outcome data. Demographics and pre- and posttreatment scores on the PTSD Checklist-Specific (PCL-S) and Beck Depression Inventory-II (BDI-II) were extracted from a program evaluation database...
June 20, 2018: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29924393/what-happens-to-nutrition-intake-in-the-post-intensive-care-unit-hospitalization-period-an-observational-cohort-study-in-critically-ill-adults
#15
Emma J Ridley, Rachael L Parke, Andrew R Davies, Michael Bailey, Carol Hodgson, Adam M Deane, Shay McGuinness, D James Cooper
BACKGROUND: Little is currently known about nutrition intake and energy requirements in the post-intensive care unit (ICU) hospitalization period in critically ill patients. We aimed to describe energy and protein intake, and determine the feasibility of measuring energy expenditure during the post-ICU hospitalization period in critically ill adults. METHODS: This is a nested cohort study within a randomized controlled trial in critically ill patients. After discharge from ICU, energy and protein intake was quantified periodically and indirect calorimetry attempted...
June 20, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29924383/the-neutrophil-to-lymphocyte-ratio-as-a-marker-of-chronic-obstructive-pulmonary-disease-and-its-exacerbations-a-systematic-review-and-meta-analysis
#16
REVIEW
Panagiotis Paliogiannis, Alessandro G Fois, Salvatore Sotgia, Arduino A Mangoni, Elisabetta Zinellu, Pietro Pirina, Ciriaco Carru, Angelo Zinellu
INTRODUCTION: The main white blood cell populations, neutrophils and lymphocytes, are involved in the pathophysiology of chronic obstructive pulmonary disease (COPD). We conducted a systematic review and meta-analysis of studies investigating the relationship between the neutrophil to lymphocyte ratio (NLR, a marker of subclinical inflammation), presence of COPD, and its exacerbations. METHODS: A comprehensive literature search was conducted in Pubmed, Web of Science and Scopus databases; two investigators independently reviewed suitable studies...
June 20, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29924356/meta-analysis-of-the-effects-of-intensive-rearing-environments-on-the-performance-and-welfare-of-broiler-chickens
#17
X Averós, I Estevez
To better understand how relevant intensive systems' characteristics simultaneously affect the performance and welfare of broiler chickens, a meta-analysis of recent literature was carried out. The study determined the effects of gender, genetics, experimental initial age (EIA, d), stocking density (SD; kg/m2), group size (GS; n), bedding material (yes/no), duration of photoperiod (DP; h), divided scotoperiod (yes/no), feeding phases (1/2/3/>3), environmental control (EC; yes/no), environmental enrichment (yes/no), use of vaccines and other medications (yes/no), experimental duration (d), and relevant 2-way interactions on average daily gain (g/d), average daily feed intake (g/d), FCR (g: g), mortality (%), behavior (%), and gait score (mean value)...
June 19, 2018: Poultry Science
https://www.readbyqxmd.com/read/29924221/tazarotene-gel-with-narrow-band-uvb-phototherapy-a-synergistic-combination-in-psoriasis
#18
Surabhi Dayal, Rajiv Kaura, Priyadarshini Sahu, Vijay Kumar Jain
BACKGROUND: Narrow-band UVB (NB-UVB) has been shown to be one of the most effective treatment modalities for psoriasis. Tazarotene, a known effective anti-psoriatic modality, when combined with NB-UVB may enhance the therapeutic success. OBJECTIVE: To study clinical efficacy and safety of combination of NB-UVB with topical tazarotene 0.05% gel in psoriasis. METHOD: Thirty patients with plaque psoriasis having symmetrical lesions were enrolled for 12 weeks...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29924190/prostaglandin-antagonist-relieves-blood-retinal-barrier-breakdown-induced-by-anterior-segment-intraocular-surgery-in-a-rat-model
#19
Maosong Xie, Libin Huang, Guoxing Xu
PURPOSE: To evaluate the efficacy of prostaglandin antagonists on blood-retinal barrier breakdown induced by anterior segment intraocular simulated surgery. METHODS: Rats were randomly assigned to a negative control group, model group, nonsteroidal anti-inflammatory drugs prophylactic treatment group, nonsteroidal anti-inflammatory drugs treatment group, corticosteroid prophylactic treatment group, and corticosteroid treatment group. Four hours and 48h after modeling, the concentrations of PGE1, PGE2, and PGF2 α in the aqueous humor and vitreous body of the rat model were visualized using ELISA...
June 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29924184/the-influence-of-inspiratory-muscle-training-combined-with-the-pilates-method-on-lung-function-in-elderly-women-a-randomized-controlled-trial
#20
Guilherme Medeiros de Alvarenga, Simone Arando Charkovski, Larissa Kelin Dos Santos, Mayara Alves Barbosa da Silva, Guilherme Oliveira Tomaz, Humberto Remigio Gamba
OBJECTIVE: Aging is progressive, and its effects on the respiratory system include changes in the composition of the connective tissues of the lung that influence thoracic and lung compliance. The Powerbreathe® K5 is a device used for inspiratory muscle training with resistance adapted to the level of the inspiratory muscles to be trained. The Pilates method promotes muscle rebalancing exercises that emphasize the powerhouse. The aim of this study was to evaluate the influence of inspiratory muscle training combined with the Pilates method on lung function in elderly women...
2018: Clinics
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