Jun-Jie Huang, Jia-Ying Zhuo, Qian Wang, Yue Sun, Jia-Xin Qi, Juan-Juan Wu, Yu Zhang, Gang Chen, Peng-Fei Jiang, Yan-Yan Fan
Thrombus age determination in fatal venous thromboembolism cases is an important task for forensic pathologists. In this study, we investigated the time-dependent expressions of formyl peptide receptor 2 (FPR2) and Annexin A1 (ANXA1) in a stasis-induced deep vein thrombosis (DVT) murine model, with the aim of obtaining useful information for thrombus age timing. A total of 75 ICR mice were randomly classified into thrombosis group and control group. In thrombosis group, a DVT model was established by ligating the inferior vena cava (IVC) of mice, and thrombosed IVCs were harvested at 1, 3, 5, 7, 10, 14, and 21 days after modeling...
April 23, 2024: Forensic Science, Medicine, and Pathology