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Randomized controlled clinical trial

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https://www.readbyqxmd.com/read/29236273/prognosticating-hearing-outcome-in-patients-with-idiopathic-sudden-sensorineural-hearing-loss-by-means-of-otoacoustic-emissions-and-auditory-brainstem-response
#1
Masoud Motasaddi Zarandy, Mohammad Taghi Ashtiani, Shahin Bastaninejad, Sasan Dabiri Satri, Sevil Nasirmohtaram, Nourullah Agha Ebrahimi
This is an analytic-descriptive study, parallel with a randomized, controlled trial performed at Amir'Alam Hospital, a tertiary referral center, with the aim of evaluating the correlation between otoacoustic emission (OAE) and auditory brainstem response (ABR) findings with hearing outcome after treatment of idiopathic sudden sensorineural hearing loss (SSNHL). Sixty patients with idiopathic SSNHL who presented to the emergency services and otology clinics between 2012 and 2014, and whose symptoms had begun <10 days previously, enrolled in this study...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29236202/sentinel-lymph-node-biopsy-and-management-of-regional-lymph-nodes-in-melanoma-american-society-of-clinical-oncology-and-society-of-surgical-oncology-clinical-practice-guideline-update
#2
Sandra L Wong, Mark B Faries, Erin B Kennedy, Sanjiv S Agarwala, Timothy J Akhurst, Charlotte Ariyan, Charles M Balch, Barry S Berman, Alistair Cochran, Keith A Delman, Mark Gorman, John M Kirkwood, Marc D Moncrieff, Jonathan S Zager, Gary H Lyman
PURPOSE: To update the American Society of Clinical Oncology (ASCO)-Society of Surgical Oncology (SSO) guideline for sentinel lymph node (SLN) biopsy in melanoma. METHODS: An ASCO-SSO panel was formed, and a systematic review of the literature was conducted regarding SLN biopsy and completion lymph node dissection (CLND) after a positive sentinel node in patients with melanoma. RESULTS: Nine new observational studies, two systematic reviews and an updated randomized controlled trial (RCT) of SLN biopsy, as well as two randomized controlled trials of CLND after positive SLN biopsy, were included...
December 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29236060/the-use-of-poly-d-l-lactic-acid-pdlla-devices-for-bone-augmentation-techniques-a-systematic-review
#3
REVIEW
Marco Annunziata, Livia Nastri, Gennaro Cecoro, Luigi Guida
Poly-d,l-lactic acid (PDLLA) has been proposed in dentistry for regenerative procedures in the form of membranes, screws, and pins. The aim of this review was to evaluate the efficacy of bone augmentation techniques using PDLLA devices. A literature search was carried out by two independent and calibrated reviewers. All interventional and observational studies assessing the efficacy of bone augmentation techniques using PDLLA devices were included. Six studies were included. The relevant variability of design and methods impeded any qualitative or quantitative comparison...
December 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29236038/adverse-effects-of-amoxicillin-for-acute-lower-respiratory-tract-infection-in-primary-care-secondary-and-subgroup-analysis-of-a-randomised-clinical-trial
#4
Meera Tandan, Akke Vellinga, Robin Bruyndonckx, Paul Little, Theo Verheij, Chris C Butler, Herman Goossens, Samuel Coenen
A European placebo-controlled trial of antibiotic treatment for lower respiratory tract infection (LRTI) conducted in 16 primary care practices networks recruited participants between November 2007 and April 2010, and found adverse events (AEs) occurred more often in patients prescribed amoxicillin compared to placebo. This secondary analysis explores the causal relationship and estimates specific AEs (diarrhoea, nausea, rash) due to amoxicillin treatment for LRTI, and if any subgroup is at increased risk of any or a specific AE...
December 13, 2017: Antibiotics
https://www.readbyqxmd.com/read/29235549/treatment-for-unresectable-or-metastatic-oesophageal-cancer-current-evidence-and-trends
#5
REVIEW
Peter S N van Rossum, Nadia Haj Mohammad, Frank P Vleggaar, Richard van Hillegersberg
Approximately half of the patients diagnosed with oesophageal cancer present with unresectable or metastatic disease. Treatment for these patients aims to control dysphagia and other cancer-related symptoms, improve quality of life and prolong survival. In the past 25 years, modestly improved outcomes have been achieved in the treatment of patients with inoperable non-metastatic cancer who are medically not fit for surgery or have unresectable, locally advanced disease. Concurrent chemoradiotherapy offers the best outcomes in these patients...
December 13, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29235159/the-effect-of-green-tea-ointment-on-episiotomy-pain-and-wound-healing-in-primiparous-women-a-randomized-double-blind-placebo-controlled-clinical-trial
#6
Hadis Shahrahmani, Nourossadat Kariman, Sharareh Jannesari, Mahmoud Rafieian-Kopaei, Moghadameh Mirzaei, Sahar Ghalandari, Nasim Shahrahmani, Gashtasb Mardani
The delayed healing of episiotomy wound and its associated pain is a major problem in obstetrics. Because green tea has analgesic and wound-healing properties, the present study was conducted to determine the effect of green tea ointment on episiotomy pain and wound-healing. The green tea extract was also standardized by measuring its Phenolic and flavonoid compounds, antioxidant activity, and one of its active components, that is, Epigallocatechin gallate. The present clinical trial was conducted on 99 primiparous women visiting Afzalipour Hospital in Kerman in 2015...
December 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29235035/is-acupuncture-actually-not-effective-for-polycystic-ovary-syndrome-analysis-of-the-trial-published-in-jama
#7
Wei-Juan Gang, Xiang-Hong Jing
In recent years, acupuncture has been applied to treat more and more patients suffering from polycystic ovary syndrome (PCOS). On June 27, 2017 a paper titled "Effect of acupuncture and clomiphene in Chinese women with polycystic ovary syndrome: a randomized clinical trial" was published in Journal of the American Medical Association (JAMA). The results did not support acupuncture as an effective therapy for improving the live births in PCOS. The aim of this article was to analyze the therapeutic regimen and design of the clinical trial...
December 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29234954/low-versus-high-volume-of-culture-medium-during-embryo-transfer-a-randomized-clinical-trial
#8
George Α Sigalos, Yannis Michalopoulos, Athanasios G Kastoras, Olga Triantafyllidou, Nikos F Vlahos
PURPOSE: The aim of this prospective randomized control trial was to evaluate if the use of two different volumes (20-25 vs 40-45 μl) of media used for embryo transfer affects the clinical outcomes in fresh in vitro fertilization (IVF) cycles. METHODS: In total, 236 patients were randomized in two groups, i.e., "low volume" group (n = 118) transferring the embryos with 20-25 μl of medium and "high volume" group (n = 118) transferring the embryos with 40-45 μl of medium...
December 12, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29234943/enhanced-recovery-care-versus-traditional-care-after-laparoscopic-liver-resections-a-randomized-controlled-trial
#9
Xiao Liang, Hanning Ying, Hongwei Wang, Hongxia Xu, Minjun Liu, Haiyan Zhou, Huiqing Ge, Wenbin Jiang, Lijun Feng, Hui Liu, Yingchun Zhang, Zhiying Mao, Jianhua Li, Bo Shen, Yuelong Liang, Xiujun Cai
BACKGROUND: Enhanced recovery after surgery (ERAS), with several evidence-based elements, has been shown to shorten length of hospital stay and reduce perioperative hospital costs in many operations. This randomized clinical trial was performed to compare complications and hospital stay of laparoscopic liver resection between ERAS and traditional care. METHODS: A randomized controlled trial was performed for laparoscopic liver resection from August 2015 to August 2016...
December 12, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29234941/short-term-surgical-outcomes-of-a-randomized-controlled-trial-comparing-laparoscopic-versus-open-gastrectomy-with-d2-lymph-node-dissection-for-advanced-gastric-cancer
#10
Yan Shi, Xianhui Xu, Yongliang Zhao, Feng Qian, Bo Tang, Yingxue Hao, Huaxing Luo, Jun Chen, Peiwu Yu
BACKGROUND: Laparoscopy-assisted gastrectomy (LAG) has gained acceptance as one of the best treatments for early gastric cancer. However, the application of LAG with D2 lymph node dissection in patients with locally advanced gastric cancer (AGC) remains controversial. METHODS: We launched a prospective randomized controlled trial comparing laparoscopic and open gastrectomy with D2 lymph node dissection for locally AGC to evaluate technical safety and oncologic feasibility...
December 12, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29234886/recovery-after-intracorporeal-anastomosis-in-laparoscopic-right-hemicolectomy-a-systematic-review-and-meta-analysis
#11
Marco Milone, Ugo Elmore, Andrea Vignali, Nicola Gennarelli, Michele Manigrasso, Morena Burati, Francesco Milone, Giovanni Domenico De Palma, Paolo Delrio, Riccardo Rosati
PURPOSE: Although intracorporeal anastomosis (IA) appears to guarantee a faster recovery compared to extracorporeal anastomosis (EA), the data are still unclear. Thus, we performed a systematic review of the literature with meta-analysis to evaluate the recovery benefits of intracorporeal anastomosis. MATERIALS AND METHODS: A systematic search was performed in electronic databases (PubMed, Web of Science, Scopus, EMBASE) using the following search terms in all possible combinations: "laparoscopic," "right hemicolectomy," "right colectomy," "intracorporeal," "extracorporeal," and "anastomosis...
December 12, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29234869/a-controlled-trial-of-inhaled-bronchodilators-in-familial-dysautonomia
#12
Bat-El Bar-Aluma, Ori Efrati, Horacio Kaufmann, Jose-Alberto Palma, Lucy Norcliffe-Kaufmann
BACKGROUND: Chronic lung disease is a leading cause of premature death in patients with familial dysautonomia (FD). A significant number of patients have obstructive airway disease, yet it is not known whether this is pharmacologically reversible. METHODS: We conducted a double-blind, placebo-controlled, randomized clinical trial comparing the beta 2 agonist albuterol with the muscarinic blocker ipratropium bromide in patients homozygous for the IKBKAP founder mutation...
December 12, 2017: Lung
https://www.readbyqxmd.com/read/29234826/mental-health-impact-of-social-capital-interventions-a-systematic-review
#13
Elaine C Flores, Daniela C Fuhr, Angela M Bayer, Andres G Lescano, Nicki Thorogood, Victoria Simms
PURPOSE: Mental disorders are a major contributor to the global burden of disease and disability, and can be extremely costly at both individual and community level. Social capital, (SC) defined as an individual's social relationships and participation in community networks, may lower the risk of mental disorders while increasing resilience capacity, adaptation and recovery. SC interventions may be a cost-effective way of preventing and ameliorating these conditions. However, the impact of these SC interventions on mental health still needs research...
December 12, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29234808/effect-of-levothyroxine-on-miscarriage-among-women-with-normal-thyroid-function-and-thyroid-autoimmunity-undergoing-in-vitro-fertilization-and-embryo-transfer-a-randomized-clinical-trial
#14
Haining Wang, Hongwei Gao, Hongbin Chi, Lin Zeng, Wenhua Xiao, Yanrong Wang, Rong Li, Ping Liu, Chen Wang, Qing Tian, Zehong Zhou, Jin Yang, Ye Liu, Rui Wei, Ben Willem J Mol, Tianpei Hong, Jie Qiao
Importance: Presence of thyroid autoantibodies in women with normal thyroid function is associated with increased risk of miscarriage. Whether levothyroxine treatment improves pregnancy outcomes among women undergoing in vitro fertilization and embryo transfer (IVF-ET) is unknown. Objective: To determine the effect of levothyroxine on miscarriage among women undergoing IVF-ET who had normal thyroid function and tested positive for thyroid autoantibodies. Design, Setting, and Participants: An open-label, randomized clinical trial involving 600 women who tested positive for the antithyroperoxidase antibody and were being treated for infertility at Peking University Third Hospital from September 2012 to March 2017...
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29234749/sinus-lift-grafting-with-anorganic-bovine-bone-vs-50-autologous-bone-mixed-with-50-anorganic-bovine-bone-2-years-after-loading-results-from-a-randomised-controlled-trial
#15
Silvio Mario Meloni, Sascha Alekshander Jovanovic, Milena Pisano, Erta Xhanari, Giacomo De Riu, Antonio Tullio, Marco Tallarico
PURPOSE: To compare the outcome of implants inserted in maxillary sinuses augmented with anorganic bovine bone (ABB) grafts vs mixed 50% ABB and 50% autologous bone graft, using a lateral window approach. MATERIALS AND METHODS: This study was designed as a randomised controlled trial of parallel groups. Patients in need of an implant-supported prosthesis in a maxillary posterior area with a residual alveolar bone height no greater than 4 mm (range 0-4 mm) were recruited for lateral sinus grafting...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29234745/the-influence-of-repeated-abutment-changes-on-peri-implant-tissue-stability-3-year-post-loading-results-from-a-multicentre-randomised-controlled-trial
#16
Eriberto Bressan, Maria Gabriella Grusovin, Ferdinando D'Avenia, Konrad Neumann, Luca Sbricoli, Giuseppe Luongo, Marco Esposito
PURPOSE: To evaluate the influence of at least three abutment disconnections in conventional loaded implants against placement of a definitive abutment in immediately non-occlusal loaded implants on hard and soft tissue changes. A secondary aim was to evaluate whether the presence of less than 2 mm of keratinised mucosa is associated with increased peri-implant marginal bone loss and soft tissue recessions. MATERIALS AND METHODS: Eighty patients requiring one single crown or one fixed partial prosthesis supported by a maximum of three implants were randomised, after implants were placed with more than 35 Ncm, according to a parallel group design to receive definitive abutments that were loaded immediately (definitive abutment or immediate loading group) or transmucosal abutments, which were delayed loaded after 3 months and removed at least three times: 1...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29234564/shoulder-external-rotator-eccentric-training-versus-general-shoulder-exercise-for-subacromial-pain-syndrome-a-randomized-controlled-trial
#17
Eric J Chaconas, Morey J Kolber, William J Hanney, Matthew L Daugherty, Stanley H Wilson, Charles Sheets
Background: Shoulder pain affects up to 67% of the population at some point in their lifetime with subacromial pain syndrome (SAPS) representing a common etiology. Despite a plethora of studies there remains conflicting evidence for appropriate management of SAPS. Purpose: To compare outcomes, for individuals diagnosed with SAPS, performing a 6-week protocol of eccentric training of the shoulder external rotators (ETER) compared to a general exercise (GE) protocol...
December 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29234556/transversus-abdominis-activation-and-timing-improves-following-core-stability-training-a-randomized-trial
#18
Noelle M Selkow, Molly R Eck, Stephen Rivas
Background: Patients with non-specific low back pain (LBP) often present with a decrease in transversus abdominis (TrA) muscle activation and delayed onset of contraction with extremity movements, potentially contributing to recurrent LBP. Core stability is required for extremity movement and if the timing of when the TrA contracts is not corrected patients may continue to experience LBP. Hypothesis/Purpose: The purpose of this study was to assess the effects of a four-week core stability rehabilitation program on TrA activation ratio and when the TrA initiates contraction during upper extremity movements in subjects with and without LBP...
December 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29234504/the-effects-of-low-intensity-blood-flow-restricted-exercise-compared-with-conventional-resistance-training-on-the-clinical-outcomes-of-active-uk-military-personnel-following-a-3-week-in-patient-rehabilitation-programme-protocol-for-a-randomized-controlled-feasibility
#19
Peter Ladlow, Russell J Coppack, Shreshth Dharm-Datta, Dean Conway, Edward Sellon, Stephen D Patterson, Alexander N Bennett
Background: A challenge for rehabilitation practitioners lies in designing optimal exercise programmes that facilitate musculoskeletal (MSK) adaptations whilst simultaneously accommodating biological healing and the safe loading of an injured limb. A growing body of evidence supports the use of resistance training at a reduced load in combination with blood flow restriction (BFR) to enhance hypertrophic and strength responses in skeletal muscle. In-patient rehabilitation has a long tradition in the UK Military, however, the efficacy of low intensity (LI) BFR training has not been tested in this rehabilitation setting...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29234503/study-protocol-for-a-phase-ii-dose-evaluation-randomized-controlled-trial-of-cholecalciferol-in-critically-ill-children-with-vitamin-d-deficiency-vitdal-picu-study
#20
Dayre McNally, Karin Amrein, Katharine O'Hearn, Dean Fergusson, Pavel Geier, Matt Henderson, Ali Khamessan, Margaret L Lawson, Lauralyn McIntyre, Stephanie Redpath, Hope A Weiler, Kusum Menon
Background: Clinical research has recently demonstrated that vitamin D deficiency (VDD) is highly prevalent in the pediatric intensive care unit (PICU) and associated with worse clinical course. Multiple adult ICU trials have suggested that optimization of vitamin D status through high-dose supplementation may reduce mortality and improve other clinically relevant outcomes; however, there have been no trials of rapid normalization in the PICU setting. The objective of this study is to evaluate the safety and efficacy of an enteral weight-based cholecalciferol loading dose regimen in critically ill children with VDD...
2017: Pilot and Feasibility Studies
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