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myocardial infarction with normal coronary artery

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https://www.readbyqxmd.com/read/28095482/an-increase-in-mean-platelet-volume-platelet-count-ratio-is-associated-with-vascular-access-failure-in-hemodialysis-patients
#1
Dong Ho Shin, So Yon Rhee, Hee Jung Jeon, Ji-Young Park, Shin-Wook Kang, Jieun Oh
After stenosis of arteriovenous vascular access in hemodialysis patients, platelets play a crucial role in subsequent thrombus formation, leading to access failure. In a previous study, the mean platelet volume (MPV)/platelet count ratio, but not MPV alone, was shown to be an independent predictor of 4-year mortality after myocardial infarction. However, little is known about the potential influence of MPV/platelet count ratio on vascular access patency in hemodialysis patients. A total of 143 patients undergoing routine hemodialysis were recruited between January 2013 and February 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28087914/-atorvastatin-improves-reflow-after-percutaneous-coronary-intervention-in-patients-with-acute-st-segment-elevation-myocardial-infarction-by-decreasing-serum-uric-acid-level
#2
Ling Yan, Lu Ye, Kun Wang, Jie Zhou, Chunjia Zhu
Objective: To investigate the effect of atorvastatin on reflow in patients with acute ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) and its relation to serum uric acid levels. Methods: One hundred and fourteen STEMI patients undergoing primary PCI were enrolled and randomly divided into two groups:55 cases received oral atorvastatin 20 mg before PCI (routine dose group) and 59 cases received oral atorvastatin 80 mg before PCI (high dose group). According to the initial serum uric acid level, patients in two groups were further divided into normal uric acid subgroup and hyperuricemia subgroup...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28077227/impact-of-nutritional-assessment-and-body-mass-index-on-cardiovascular-outcomes-in-patients-with-stable-coronary-artery-disease
#3
Ayako Kunimura, Hideki Ishii, Tadayuki Uetani, Toshijirou Aoki, Kazuhiro Harada, Kenshi Hirayama, Yosuke Negishi, Yohei Shibata, Takuya Sumi, Kazuhiro Kawashima, Yosuke Tatami, Toshiki Kawamiya, Dai Yamamoto, Susumu Suzuki, Tetsuya Amano, Toyoaki Murohara
BACKGROUND: An inverse association between obesity, as defined by body mass index (BMI) and prognosis has been reported in patients with cardiovascular disease ("obesity paradox"). The aim of this study was to investigate whether adding nutritional information to BMI provides better risk assessment in patients undergoing elective percutaneous coronary intervention (PCI). METHOD: This study comprised 1004 patients undergoing elective PCI. We calculated each patient's controlling nutritional status (CONUT) score for nutritional screening at baseline...
January 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28056234/-effect-of-intracoronary-autologous-bone-marrow-mononuclear-cells-transplantation-on-arrhythmia-in-canines
#4
J Tang, G Y Sun, T Chen, Y D Wang, J Zhang, X Q Qi
Objective: To observe the survival and the differentiation of grafted bone marrow cells (BM-MNCs) in host myocardium. To observe whether BM-MNCs transplantation can potentially cause arrhythmia and whether the BM-MNCs transplantation can alter the spatial distribution of connexins, important mediator for arrhythmia genesis after myocardial infarction. Methods: Acute myocardial infarction (AMI) was induced by left anterior descending coronary artery (LAD) ligation in hybrid canine. BM-MNCs suspension was prepared by density centrifugation...
December 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28049598/prognostic-value-of-myocardial-perfusion-analysis-in-patients-with-coronary-artery-disease-a-meta-analysis
#5
Jiancheng Xiu, Kai Cui, Yuegang Wang, Hua Zheng, Gangbin Chen, Qian Feng, Jianping Bin, Juefei Wu, Thomas R Porter
BACKGROUND: Myocardial perfusion (MP) imaging during stress myocardial contrast echocardiography (MCE) improves the detection of coronary artery disease (CAD). However, its prognostic value to predict cardiac events in patients with known or suspected CAD is still undefined. METHODS: A search was conducted for single- or multicenter prospective studies that evaluated the prognostic value of stress MCE in patients with known or suspected CAD. A database search was performed through June 2015...
December 31, 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28040272/myocardial-strain-may-be-useful-in-differentiating-takotsubo-cardiomyopathy-from-left-anterior-descending-coronary-artery-ischemia
#6
LiYing Cai, Karima Addetia, Diego Medvedofsky, Kirk T Spencer
BACKGROUND: Stress-induced cardiomyopathy (SCM) is characterized by transient apical wall motion abnormalities of the left ventricle (LV) in the absence of obstructive coronary artery disease. Although the echocardiographic findings of SCM mimic those of left anterior descending coronary artery ischemia or infarction (LAD), the regional LV wall motion pattern and degree of RV involvement may differ. METHODS: We sought to systematically assess regional LV and RV function with myocardial strain imaging to assess if ventricular involvement may differ between SCM and LAD...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28039940/epac-rap1-activated-mesenchymal-stem-cells-improve-cardiac-function%C3%A2-in-rat-model-of-myocardial-infarction
#7
Irfan Khan, Anwar Ali, Muhammad Aleem Akhter, Nadia Naeem, Maqsood Ahmed Chotani, Hana'a Iqbal, Nurul Kabir, Mehnaz Atiq, Asmat Salim
INTRODUCTION: Rap1, a member of Ras superfamily of small GTP-binding proteins, is involved in cardiovascular biology in numerous ways. It is an evolutionary conserved regulator of adhesion, polarity, differentiation and growth. AIMS: Our aim was to analyze Rap1 activated rat bone marrow mesenchymal stem cells (MSCs) for their potential role in adhesion and cardiac differentiation. METHODS: Myocardial infarction (MI) was produced in Sprague Dawley (SD) rats through occlusion of the left anterior descending coronary artery...
December 31, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28039938/targeted-p2x7-r-shrna-delivery-attenuates-sympathetic-nerve-sprouting-and-ameliorates-cardiac-dysfunction-in-rats-with-myocardial-infarction
#8
Hongmei Gao, Jie Yin, Yugen Shi, Hesheng Hu, Xiaolu Li, Mei Xue, Wenjuan Cheng, Ye Wang, Xinran Li, Yongkang Li, Yu Wang, Suhua Yan
BACKGROUND: Inflammation-dominated sympathetic sprouting adjacent to the necrotic region following myocardial infarction (MI) has been implicated in the etiology of arrhythmias resulting in sudden cardiac death; however, the mechanisms responsible remain to be elucidated. Although P2X7 R is a key immune mediator, its role has yet to be explored. OBJECTIVE: We investigated whether P2X7 R regulates NF-κB and affects cardiac sympathetic reinnervation in rats undergoing MI...
December 31, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28031688/premature-atherosclerosis-and-drug-eluting-stent-restenosis-in-an-adult-with-osteogenesis-imperfecta
#9
Mutlu Gungor, Mustafa Aparci, Ali C Özer
Mild form of osteogenesis imperfecta (OI) may have a normal life span. However, cardiovascular complications including aortic and valvular heart disease, and coronary artery disease may complicate the life period. We presented a patient with mild form of OI and premature coronary atherosclerosis. He had been performed primary percutaneous angioplasty and drug eluting stent implantation to left anterior descending coronary artery osteal lesion. Then he presented with unstable angina pectoris due to the diffuse in-stent restenosis and a highly critical lesion adjacent to previously stented segment...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28031679/elevated-factor-viii-levels-associated-with-acute-graft-occlusion-and-arterial-and-venous-thrombosis-after-off-pump-cabg
#10
Crystal A Kyaw, Pey-Jen Yu, Frank Manetta
Factor VIII is a common acute phase reactant and elevated levels confer an increased risk of thrombosis. Such thrombotic events have been documented in the literature, though to a limited extent. We present the case of a 54-year-old man presenting with a non-Q-wave myocardial infarction who was found to have triple vessel disease and subsequently underwent a 4-vessel coronary artery bypass grafting (CABG). Postoperatively, he was found to have multiple occluded vessels, deep vein thromboses, and a cerebrovascular accident (CVA)...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28031640/rheumatic-heart-disease-predisposing-to-embolic-myocardial-infarction-a-multimodality-imaging-approach
#11
Emanuele Canali, Giuseppe Cannavale, Giulia Conti, Simona Mariani, Fabrizio Proietti
We report a clinical case of a 45-year-old male with a diagnosis of inferior myocardial infarction and previous history of rheumatic fever during his childhood. Coronary angiography demonstrated normal coronary arteries. Transthoracic echocardiogram showed hypokinetic left ventricular inferolateral wall and mitral stenosis; furthermore, speckle tracking analysis revealed reduction of global longitudinal strain involving the inferior wall. A three-dimensional transesophaegeal echocardiography, performed to better characterize the anatomy of the valve and to find possible source of embolic infarct in an enlarged left atrium, showed rheumatic valvular involvement...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28025722/quantified-coronary-frequency-domain-optical-coherence-tomography-signal-analysis-for-the-evaluation-of-erythrocyte-rich-thrombus-ex-vivo-validation-study
#12
Yoshitaka Shiratori, Masato Watanabe, Nobuaki Suzuki, Toshio Fukusato, Ken Kozuma
Previous study has demonstrated that erythrocyte-rich thrombi contain more inflammatory cells and reflect high thrombus burden, leading to impaired myocardial reperfusion in myocardial infarction. The aim of this study is to investigate the utility of quantified frequency domain optical coherence tomography (FD-OCT) signal analysis in evaluating the erythrocyte-rich thrombus with ex-vivo materials. We evaluated 54 specimens of coronary artery thrombus obtained by thrombectomy catheter from 8 patients who underwent primary percutaneous coronary intervention...
December 26, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28024133/ranolazine-in-treatment-of-stable-angina-in-woman-with-atrial-fibrillation-and-intermittent-left-bundle-branch-block-a-case-report
#13
Natalia Yuriivna Osovska, Natalia Vitaliivna Kuzminova
Stable angina is the most frequent manifestation of ischemic heart disease (IHD) in women as compared to men (65% versus 37%). IHD in women has more favorable clinical course because myocardial infarction develops twice as rare as in men. Coronary angiography of angina patients demonstrates normal coronary arteries more frequently in women than in men. Microvascular angina (MVA) is found to be a rather common form of stable IHD as that particular diagnosis is made later in 20-30% of patients who previously underwent coronary angiography...
December 22, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28018900/redox-regulation-of-heart-regeneration-an-evolutionary-tradeoff
#14
Waleed M Elhelaly, Nicholas T Lam, Mohamed Hamza, Shuda Xia, Hesham A Sadek
Heart failure is a costly and deadly disease, affecting over 23 million patients worldwide, half of which die within 5 years of diagnosis. The pathophysiological basis of heart failure is the inability of the adult heart to regenerate lost or damaged myocardium. Although limited myocyte turnover does occur in the adult heart, it is insufficient for restoration of contractile function (Nadal-Ginard, 2001; Laflamme et al., 2002; Quaini et al., 2002; Hsieh et al., 2007; Bergmann et al., 2009, 2012). In contrast to lower vertebrates (Poss et al...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28013281/prognostic-usefulness-of-contemporary-stress-echocardiography-in-patients-with-left-bundle-branch-block-and-impact-of-contrast-use-in-improving-prediction-of-outcome
#15
Anastasia Vamvakidou, Nikos Karogiannis, Vasilis Tzalamouras, Guy Parsons, Grace Young, Sothinathan Gurunathan, Roxy Senior
AIMS: Patients with symptomatic left bundle branch block (LBBB) may have myocardial ischaemia due to both coronary artery disease and/or cardiomyopathy (microcirculatory abnormalities) and may have concomitant left ventricular (LV) dysfunction. We aimed to assess the feasibility and prognostic value of contemporary stress echocardiography (SE), which can uncover both pathophysiologies in LBBB patients in routine clinical practice, and also aimed to assess the additive value of contrast SE...
December 24, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/27987279/falsely-elevated-troponin-rare-occurrence-or-future-problem
#16
James Nguyen, Rosy Thachil, Neil Vyas, Thomas Marino
INTRODUCTION: Troponins are known to be released in response to cardiac damage and therefore are the biomarkers of choice for the early diagnosis of acute myocardial infarction (AMI), improving outcome in patients presenting with chest pain. However, false results can occur due to interference from other substances in the blood. CASE: A 52-year-old male with a past medical history of alcohol abuse, hypertension, and coronary artery bypass graft at age 34 with normal stress test 2 years before presented to the emergency department (ED) complaining of 1 day of non-exertional chest pain with radiation to the neck and left arm...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27937806/association-between-hyperuricemia-and-major-adverse-cardiac-events-in-patients-with-acute-myocardial-infarction
#17
Naresh Ranjith, Nomcebo N Myeni, Ben Sartorius, Chamsanqua Mayise
BACKGROUND: To investigate the association between hyperuricemia and major adverse cardiac events (MACE) in patients with acute myocardial infarction (AMI). METHODS: Consecutive patients admitted with AMI to the Coronary Care Unit at R. K. Khan Hospital (Durban, South Africa) between the years 2006 and 2014 were included. Demographic data, including clinical and biochemical information stored in an electronic database, were obtained from all patients. RESULTS: A total of 2683 patients were studied, of whom 65% were males...
December 12, 2016: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/27936390/irap-inhibition-using-hfi419-prevents-moderate-to-severe-acetylcholine-mediated-vasoconstriction-in-a-rabbit-model
#18
Aisha El-Hawli, Tawar Qaradakhi, Alan Hayes, Emma Rybalka, Renee Smith, Martin Caprnda, Radka Opatrilova, Katarina Gazdikova, Maria Benckova, Peter Kruzliak, Anthony Zulli
Coronary artery vasospasm (constriction) caused by reduced nitric oxide bioavailability leads to myocardial infarction. Reduced endothelial release of nitric oxide by the neurotransmitter acetylcholine, leads to paradoxical vasoconstriction as it binds to smooth muscle cell M3 receptors. Thus, inhibition of coronary artery vasospasm will improve clinical outcomes. Inhibition of insulin regulated aminopeptidase has been shown to improve vessel function, thus we tested the hypothesis that HFI419, an inhibitor of insulin regulated aminopeptidase, could reduce blood vessel constriction to acetylcholine...
December 6, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27935217/takotsubo-cardiomyopathy-after-cesarean-section-a-case-report-and-literature-review
#19
Sara Ruiz, Miguel Martinez-Marin, Pilar Luque, Nadia Nassar, Daniel Oros
Takotsubo cardiomyopathy (TCM) is clinically identical to acute myocardial infarction. We report an unusual case of TCM and review similar cases in pregnant women. A young woman with no pre-existing cardiovascular risk factors suffered sudden dyspnea during a cesarean section. Electrocardiography (ECG) showed T-wave inversion. We observed acute lung edema and left ventricular systolic dysfunction on echocardiography. A cardiac catheterization diagnosed TCM. We reviewed 20 cases of TCM; 17 cases occurred during the post-partum period and three during pregnancy...
December 9, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27932153/a-heartbreaking-renal-transplantation-is-norepinephrine-the-culprit-to-blame
#20
M G Vailas, S Vernadakis, K Kakavia, I Paizis, J Bokos, J Boletis, G Zavos
INTRODUCTION: Takotsubo cardiomyopathy (TCM), also known as "broken heart syndrome," "apical ballooning syndrome," and "stress-induced cardiomyopathy," was first described in Japanese patients in 1990 by Sato et al. TCM is an increasingly recognized syndrome characterized by transient and reversible systolic dysfunction of the apical and middle segments of the left ventricle. This syndrome resembles acute myocardial infarction in the absence of evident coronary artery occlusion. Herein, we present a case of a 51-year-old male who underwent his second deceased-donor renal transplantation for end-stage-renal-disease due to a work-related accident...
November 2016: Transplantation Proceedings
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