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myocardial infarction with normal coronary artery

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https://www.readbyqxmd.com/read/29785154/detection-of-coronary-artery-disease-by-reduced-features-and-extreme-learning-machine
#1
Ram Sewak Singh, Barjinder Singh Saini, Ramesh Kumar Sunkaria
Objective: Cardiovascular diseases generate the highest mortality in the globe population, mainly due to coronary artery disease (CAD) like arrhythmia, myocardial infarction and heart failure. Therefore, an early identification of CAD and diagnosis is essential. For this, we have proposed a new approach to detect the CAD patients using heart rate variability (HRV) signals. This approach is based on subspaces decomposition of HRV signals using multiscale wavelet packet (MSWP) transform and entropy features extracted from decomposed HRV signals...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29781184/pre-operative-dobutamine-stress-echocardiography-in-patients-undergoing-orthotopic-liver-transplantation
#2
Krishna K Patel, Laura Young, William Carey, Kathryn A Kohn, Richard A Grimm, L Leonardo Rodriguez, Brian P Griffin, Milind Y Desai
BACKGROUND: Coronary artery disease (CAD) is associated with increased mortality in patients that undergo orthotopic liver transplantation (OLT). Due to chronic vasodilatory state and poor exercise tolerance in patients with end stage liver disease, dobutamine stress echocardiography (DSE) is preferred for preoperative evaluation of CAD prior to OLT. We sought to a) study the incidence of positive DSE results and b) test whether there is an association between DSE results and perioperative and longer-term events...
May 20, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29778671/international-study-of-comparative-health-effectiveness-with-medical-and-invasive-approaches-ischemia-trial-rationale-and-design
#3
David J Maron, Judith S Hochman, Sean M O'Brien, Harmony R Reynolds, William E Boden, Gregg W Stone, Sripal Bangalore, John A Spertus, Daniel B Mark, Karen P Alexander, Leslee Shaw, Jeffrey S Berger, T Bruce Ferguson, David O Williams, Robert A Harrington, Yves Rosenberg
BACKGROUND: Prior trials comparing a strategy of optimal medical therapy with or without revascularization have not shown that revascularization reduces cardiovascular events in patients with stable ischemic heart disease (SIHD). However, those trials only included participants in whom coronary anatomy was known prior to randomization and did not include sufficient numbers of participants with significant ischemia. It remains unknown whether a routine invasive approach offers incremental value over a conservative approach with catheterization reserved for failure of medical therapy in patients with moderate or severe ischemia...
April 21, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29758552/downregulation-of-s100a4-alleviates-cardiac-fibrosis-via-wnt-%C3%AE-catenin-pathway-in-mice
#4
LiJun Qian, Jian Hong, YanMei Zhang, MengLin Zhu, XinChun Wang, YanJuan Zhang, Ming Chu, Jing Yao, Di Xu
BACKGROUND/AIMS: Cardiac fibrosis is a pathological change leading to cardiac remodeling during the progression of myocardial ischemic diseases, and its therapeutic strategy remains to be explored. S100A4, a calcium-binding protein, participates in fibrotic diseases with an unclear mechanism. This study aimed to investigate the role of S100A4 in cardiac fibrosis. METHODS: Cardiac fibroblasts from neonatal C57BL/6 mouse hearts were isolated and cultured. Myocardial infarction was induced by ligating the left anterior descending coronary artery (LAD)...
May 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29754654/dual-antiplatelet-therapy-for-perioperative-myocardial-infarction-following-cabg-surgery
#5
Alice Wang, Angie Wu, Daniel Wojdyla, Renato D Lopes, L Kristin Newby, Mark F Newman, Peter K Smith, John H Alexander
OBJECTIVES: Perioperative myocardial infarction (MI) after coronary artery bypass graft surgery (CABG) has been associated with adverse outcome. Whether perioperative MI should be treated with dual antiplatelet therapy (DAPT) is unknown. We compared the effect of DAPT versus aspirin alone on short-term outcomes among patients with perioperative MI following CABG. METHODS: We used data from 3 clinical trials that enrolled patients undergoing isolated CABG: PREVENT IV (2002-2003), MEND-CABG II (2004-2005), and RED-CABG (2009-2010) (n = 9117)...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29742921/long-term-prognostic-value-of-coronary-computed-tomography-angiography-in-chest-pain-patients
#6
Mårten Sandstedt, Jakob De Geer, Lilian Henriksson, Jan Engvall, Magnus Janzon, Anders Persson, Joakim Alfredsson
Background Coronary computed tomography angiography (CCTA) is increasingly used to detect coronary artery disease (CAD), but long-term follow-up studies are still scarce. Purpose To evaluate the prognostic value of CCTA in patients with suspected CAD. Material and Methods A total of 1205 consecutive CCTA patients with chest pain were classified as normal coronary arteries, non-obstructive CAD, or obstructive CAD. The primary outcome was major adverse cardiac event (MACE), defined as a composite outcome including cardiac death, myocardial infarction, unstable angina pectoris, or late revascularization (after >90 days)...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29738542/microvascular-retinopathy-and-angiographically-demonstrated-coronary-artery-disease-a-cross-sectional-observational-study
#7
Lisa Cheng, Peter Barlis, Joel Gibson, Deb Colville, Anastasia Hutchinson, Geoff Gleeson, Ecosse Lamoureux, William VanGaal, Judy Savige
Epidemiological studies suggest retinal microvascular abnormalities predict cardiac events. This study examined microvascular features associated with coronary artery abnormalities. This was a single-centre, cross-sectional, observational study of 144 consecutive subjects undergoing coronary angiography for clinical indications. Their angiograms were deidentified and graded for disease (Leaman score, LAD stenosis ≥ 70%, number of vessels stenosed ≥ 70%), and Thrombolysis in Myocardial Infarction (TIMI) blush score...
2018: PloS One
https://www.readbyqxmd.com/read/29736108/acute-coronary-syndrome-with-normal-coronary-arteries-a-case-of-spontaneous-spasm-lysis
#8
Vogiatzis Ioannis, Koutsambasopoulos Konstantinos, Samaras Antonios, Bostanitis Ioannis
Introduction: Patients suffering from Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) are found with no obstructive coronary artery disease on coronary arteriography. The Aim of this interesting case report is to present a patient with acute chest pain, temporal ST-segment elevation and MINOCA. Case report: A case of a young woman who presented with acute chest pain suggestive of angina, with temporal ST-segment elevation, accidentally recorded and not rising of myocardial necrosis biomarkers in blood tests is described...
April 2018: Medical Archives
https://www.readbyqxmd.com/read/29731349/coronary-artery-ectasia-an-independent-predictor-of-no-reflow-after-primary-pci-for-st-elevation-myocardial-infarction
#9
H C F Schram, V V Hemradj, R S Hermanides, E Kedhi, J P Ottervanger
BACKGROUND: The no-reflow phenomenon is a serious complication after primary percutaneous coronary intervention (PCI) for ST-elevation Myocardial Infarction (STEMI). Coronary artery ectasia (CAE) may increase the risk of no-reflow, however, only limited data is available on the potential impact of CAE. The aim of this study was to determine the potential association between CAE and no-reflow after primary PCI. METHODS: A case control study was performed based on a prospective cohort of STEMI patients from January 2000 to December 2011...
April 25, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29725379/evaluation-of-effect-of-atorvastatin-on-left-ventricular-systolic-function-in-rats-with-myocardial-infarction-via-2d-sti-technique
#10
Yan Hua, Manying Xie, Jiabao Yin, Yu Wang, Ling Gan, Ming Sang, Xiaodong Sun, Mingyang Li, Shanjun Liu, Jinzhi Xu
This report aims to evaluate the effect of atorvastatin (Ator) on left ventricular systolic function in myocardial infarction (MI) rats. Forty healthy adult Sprague-Dawley rats were randomly divided into four groups: Ator group, MI group, sham-operation group and normal group. The left anterior descending coronary arteries were ligated to establish the MI model; after modeling, the Ator group was treated with Ator for 4 consecutive weeks. The echocardiographic detection was performed; the left ventricular myocardial systolic peak velocities, strain and strain rates were analyzed using the 2D-STI technique...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29720503/clinical-characteristics-sex-differences-and-outcomes-in-patients-with-normal-or-near-normal-coronary-arteries-non-obstructive-or-obstructive-coronary-artery-disease
#11
Michelle L Ouellette, Adrián I Löffler, George A Beller, Virginia K Workman, Eric Holland, Jamieson M Bourque
BACKGROUND: Normal or near-normal coronary arteries (NNCAs) or nonobstructive coronary artery disease (CAD) are found on invasive coronary angiography in ≈55% of patients. Some attribute this to frequent referral of low-risk patients. We sought to identify the referral indications, pretest risk, key clinical characteristics, sex, and outcomes in patients with NNCAs and nonobstructive CAD versus obstructive CAD on nonemergent invasive coronary angiography. METHODS AND RESULTS: Over 24 months, 925 consecutive patients were classified as having NNCAs (≤20% stenosis), nonobstructive CAD (21-49% stenosis), or obstructive CAD (≥50% stenosis)...
May 2, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29717990/-minoca-in-iceland-acute-coronary-syndrome-in-patients-with-normal-or-nonobstructive-coronary-arteries
#12
Saevar Thor Vignisson, Ingibjorg Jona Gudmundsdottir, Thorarinn Gudnason, Ragnar Danielsen, Marianna Gardarsdottir, Karl Andersen
INTRODUCTION: The classical pathophysiological process underlying acute coronary syndromes has been considered to be plaque rup-ture followed by platelet activation and aggregation and subsequent thrombus formation leading to myocardial ischemia and infarction. A substantial number of patients with acute coronary syndromes appear to have normal or near normal (<50% stenosis) coronary arteries on angiography. Recently, this clinical entity has been coined MINOCA (Myocardial Infarction with Non-Obstructive Coronary Arteries)...
May 2018: Læknablađiđ
https://www.readbyqxmd.com/read/29716697/incidence-predictors-clinical-profile-management-and-outcome-of-patients-with-isolated-left-main-coronary-artery-ostial-disease
#13
Sunil Kumar Srinivas, Bharathi Sunil, Prabhavathi Bhat, Cholenahally Nanjappa Manjunath
OBJECTIVES: Isolated left main coronary artery (LMCA) ostial disease is a rare variant of LMCA disease. Earlier studies on this disease are limited by small number of patients enrolled. The aim of the present study was to analyze the incidence, risk factors, clinical profile and long term outcome of patients with isolated LMCA ostial disease. METHODS: 15,553 patients who underwent coronary angiogram in a single tertiary care cardiac hospital were analyzed for LMCA disease...
March 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29699748/a-randomized-double-blind-placebo-controlled-study-comparing-intracoronary-versus-intravenous-abciximab-in-patients-with-st-elevation-myocardial-infarction-undergoing-transradial-rescue-percutaneous-coronary-intervention-after-failed-thrombolysis
#14
Olivier F Bertrand, Éric Larose, Rodrigo Bagur, Frédéric Maes, Valérie Gaudreault, Bernard Noël, Gérald Barbeau, Jean-Pierre Déry, Charles Pirlet, Olivier Costerousse
The risk and benefit ratio of glycoprotein IIb/IIIa inhibitors with dual oral antiplatelet therapy after failed thrombolysis and rescue percutaneous coronary intervention (PCI) is unclear. Using a randomized placebo-controlled, double-blind design, we compared intravenous (IV) and intracoronary (IC) abciximab delivery in 74 patients referred for rescue transradial PCI. The primary angiographic end points were the final thrombolysis in myocardial infarction flow and myocardial blush grades. Secondary end points included acute and 6-month outcomes using angiographic parameters, platelet aggregation parameters, cardiac biomarkers, cardiac magnetic resonance measurements (CMR) and clinical end points...
March 28, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29688324/determinants-of-long-term-clinical-outcomes-in-patients-with-angina-but-without-obstructive-coronary-artery-disease-a-systematic-review-and-meta-analysis
#15
Francesco Radico, Marco Zimarino, Fabio Fulgenzi, Fabrizio Ricci, Marta Di Nicola, Lasse Jespersen, Su Min Chang, Karin H Humphries, Mario Marzilli, Raffaele De Caterina
Aims: The long-term prognosis of angina in patients without obstructive coronary artery disease (CAD) is uncertain. To assess the incidence of long-term adverse outcomes in such patients. Methods and results: We searched PubMed, Cochrane Library, the Embase database, and the Clinical Trials Registry for studies published in English until January 2017, assessing the composite primary outcome of all-cause death and non-fatal myocardial infarction using random-effects models to estimate pooled incidences...
April 23, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29688287/implications-of-coronary-artery-bypass-grafting-and-percutaneous-coronary-intervention-on-disease-progression-and-the-resulting-changes-to-the-physiology-and-pathology-of-the-native-coronary-arteries
#16
Jacqueline H Fortier, Giovanni Ferrari, David Glineur, Mario Gaudino, Richard E Shaw, Marc Ruel, Juan B Grau
Myocardial revascularization can be achieved through 2 different methods: coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). Clinical trials comparing PCI and CABG generally use the composite end points of death, stroke, myocardial infarction and target vessel revascularization to determine superiority. Other effects of these interventions, including the preservation of normal coronary physiology, the response of the coronary tree to stressors and the response of the vessel wall to the revascularization intervention, are not routinely considered, but these may have significant implications for patients in the medium and long term...
April 23, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29679222/warranty-period-of-normal-stress-myocardial-perfusion-imaging-in-hypertensive-patients-a-parametric-survival-analysis
#17
Wanda Acampa, Francesco Rozza, Emilia Zampella, Roberta Assante, Teresa Mannarino, Carmela Nappi, Ciro Mainolfi, Mario Petretta, Bruno Trimarco, Alberto Cuocolo
BACKGROUND: We evaluated the warranty period of a normal stress myocardial perfusion single-photon emission computed tomography (MPS) in hypertensive patients. METHODS AND RESULTS: A total of 471 consecutive hypertensive patients with suspected coronary artery disease and normal perfusion at stress MPS were followed for a mean of 76 ± 21 months. Endpoint events were cardiac death or nonfatal myocardial infarction. With Cox analysis, age (hazard ratio 1.1, P < ...
April 20, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29678849/effects-of-adenovirus-mediated-vegf165-gene-therapy-on-myocardial-infarction
#18
Chao Wang, Boya Zhang, Yu Lin, Yang Dong
AIM: To evaluate the role of adenovirus-mediated transduction human VEGF isoform 165 via direct myocardial injection in rats with an occluded circumflex coronary artery, and the possible underlying mechanism. METHODS: Sprague-Dawley rats were induced myocardial infarction (MI) with ligation of the left coronary artery. Rats were randomly divided into 4 groups: 1) the sham group; 2) the MI group; 3) the NS (normal saline) group and 4) the VEGF group. Direct myocardial injection of 0...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29672210/prognostic-utility-of-stress-testing-and-cardiac-biomarkers-in-menopausal-women-at-low-to-intermediate-risk-for-coronary-artery-disease-smart-study-5-year-outcome
#19
Sahar S Abdelmoneim, Caroline A Ball, Francesca Mantovani, Mary E Hagen, Susan Eifert-Rain, Susan Wilansky, Ramon Castello, Patricia A Pellikka, Patricia J M Best, Sharon L Mulvagh
BACKGROUND: In women with low to intermediate risk of coronary artery disease (CAD), prognostic detection strategies have been controversial. We present the follow-up data of the SMART trial in peri/postmenopausal women at low to intermediate risk of CAD. OBJECTIVES: To determine the value of contrast stress echocardiography (CSE), stress electrocardiogram (sECG), and serum biomarkers for prediction of cardiovascular events (CE) in peri/postmenopausal women at low to intermediate risk of CAD...
April 19, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29666071/b-type-natriuretic-peptide-assessment-in-patients-undergoing-revascularization-for-left-main-coronary-artery-disease-analysis-from-the-excel-trial
#20
Björn Redfors, Shmuel Chen, Aaron Crowley, Ori Ben-Yehuda, Bernard J Gersh, Nicholas J Lembo, W Morris Brown, Adrian P Banning, David P Taggart, Patrick W Serruys, Arie Pieter Kappetein, Joseph F Sabik, Gregg W Stone
Background -Elevated B-type natriuretic peptide (BNP) is reflective of impaired cardiac function and is associated with worse prognosis among patients with coronary artery disease (CAD). We sought to assess the association between baseline BNP, adverse outcomes, and the relative efficacy of percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) in patients with left main (LM) CAD. Methods -The EXCEL trial randomized patients with LMCAD and low or intermediate SYNTAX scores to PCI with everolimus-eluting stents versus CABG...
April 17, 2018: Circulation
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