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https://www.readbyqxmd.com/read/29054274/seventeen-year-nationwide-trends-in-antihypertensive-drug-use-in-denmark
#1
Jens Sundbøll, Kasper Adelborg, Kathryn E Mansfield, Laurie A Tomlinson, Morten Schmidt
Recent trends in use of antihypertensive drugs are unknown. From Danish nationwide prescription data, we obtained information on primary care use of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta blockers, diuretics, aldosterone receptor antagonists, and calcium channel blockers. During 1999 to 2015, the use of antihypertensive drugs per 1,000 inhabitants/day increased from 184 to 379 defined daily doses (DDD), corresponding to a rise in the prevalence proportion of users from ≈20% to ≈35%...
September 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29052707/the-spectrum-of-subclinical-primary-aldosteronism-and-incident-hypertension-a-cohort-study
#2
Jenifer M Brown, Cassianne Robinson-Cohen, Miguel Angel Luque-Fernandez, Matthew A Allison, Rene Baudrand, Joachim H Ix, Bryan Kestenbaum, Ian H de Boer, Anand Vaidya
Background: Primary aldosteronism is recognized as a severe form of renin-independent aldosteronism that results in excessive mineralocorticoid receptor (MR) activation. Objective: To investigate whether a spectrum of subclinical renin-independent aldosteronism that increases risk for hypertension exists among normotensive persons. Design: Cohort study. Setting: National community-based study. Participants: 850 untreated normotensive participants in MESA (Multi-Ethnic Study of Atherosclerosis) with measurements of serum aldosterone and plasma renin activity (PRA)...
October 10, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29052700/subclinical-primary-aldosteronism
#3
E Victor Adlin
No abstract text is available yet for this article.
October 10, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29036960/-two-cases-report-of-primary-aldosteronism-with-positive-cardiac-troponin
#4
L J Yang, H Wang, Y D Zhang
No abstract text is available yet for this article.
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29034087/spironolactone-in-cardiovascular-disease-an-expanding-universe
#5
REVIEW
John W Funder
Spironolactone has been marketed for over half a century as a 'potassium-sparing diuretic', used primarily in patients with ascites. With the realization that primary aldosteronism is the most common (5-13%) form of secondary hypertension, it has become widely used as a mineralocorticoid receptor antagonist. More recently, in the wake of the RALES trial, spironolactone in addition to standard therapy has been shown to be very beneficial in heart failure with a reduced ejection fraction. Despite the failure of the TOPCAT trial, spironolactone is being increasingly used in diastolic heart failure (i...
2017: F1000Research
https://www.readbyqxmd.com/read/29032132/prognostic-importance-of-temporal-changes-in-resting-heart-rate-in-heart-failure-and-preserved-ejection-fraction-from-the-topcat-study
#6
Ali Vazir, Brian Claggett, Bertram Pitt, Inder Anand, Nancy Sweitzer, James Fang, Jerome Fleg, Jean Rouleau, Sanjiv Shah, Marc A Pfeffer, Scott D Solomon
OBJECTIVES: The aim of this study was to examine the relationship between baseline heart rate (HR), change in HR from a preceding visit, and time-updated HR with subsequent outcomes in patients with heart failure with preserved ejection fraction (HFpEF) in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) trial. BACKGROUND: Higher resting HR and increase in HR over time in patients with heart failure are associated with adverse outcomes...
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29030398/on-the-effect-of-hyperaldosteronism-inducing-mutations-in-na-k-pumps
#7
Dylan J Meyer, Craig Gatto, Pablo Artigas
Primary aldosteronism, a condition in which too much aldosterone is produced and that leads to hypertension, is often initiated by an aldosterone-producing adenoma within the zona glomerulosa of the adrenal cortex. Somatic mutations of ATP1A1, encoding the Na/K pump α1 subunit, have been found in these adenomas. It has been proposed that a passive inward current transported by several of these mutant pumps is a "gain-of-function" activity that produces membrane depolarization and concomitant increases in aldosterone production...
October 13, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/29016737/diverging-effects-of-enalapril-or-eplerenone-in-primary-prevention-against-doxorubicin-induced-cardiotoxicity
#8
Roger Hullin, Mélanie Métrich, Alexandre Sarre, Denis Basquin, Marc Maillard, Julien Regamey, David Martin
Aims: Clinical studies suggest beneficial effects of renin-angiotensin system blockade for prevention of left ventricular (LV) dysfunction after chemotherapy. However, the efficacy of this strategy as primary prevention has been poorly studied. This study aimed at identifying the pathophysiological mechanisms by which mineralocorticoid receptor antagonism (MRA) or angiotensin converting enzyme inhibition (ACEi) provide protection against doxorubicin-induced cardiotoxicity (DIC) in mouse models of acute and chronic toxicity...
September 7, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28994759/a-novel-method-super-selective-adrenal-venous-sampling
#9
Kohzoh Makita, Koshiro Nishimoto, Kanako Kiriyama-Kitamoto, Shigehiro Karashima, Tsugio Seki, Masanori Yasuda, Seishi Matsui, Masao Omura, Tetsuo Nishikawa
Primary aldosteronism (PA) and subclinical Cushing's syndrome (SCS) are conditions in which the adrenal glands autonomously produce excessive amounts of aldosterone and cortisol, respectively. The conventional adrenal venous sampling (cAVS) method collects blood samples from both adrenal central veins and is useful for identifying the laterality of excess hormone production in a unilateral lesion(s), as documented in PA cases. In cAVS, plasma cortisol concentrations (PCCs) are used to normalize plasma aldosterone concentrations (PACs)...
September 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28993452/macrolides-blunt-aldosterone-biosynthesis-a-proof-of-concept-study-in-kcnj5-mutated-adenoma-cells-ex-vivo
#10
Brasilina Caroccia, Selene Prisco, Teresa Maria Seccia, Maria Piazza, Giuseppe Maiolino, Gian Paolo Rossi
Aldosterone-producing adenoma (APA), a major subtype of primary hyperaldosteronism, the main curable cause of human endocrine hypertension, involves somatic mutations in the potassium channel Kir3.4 (KCNJ5) in 30% to 70% of cases, typically the more florid phenotypes. Because KCNJ5 mutated channels were reported to be specifically sensitive to inhibition by macrolide antibiotics, which concentration dependently blunts aldosterone production in HAC15 transfected with the G151R and L168R mutated channel, we herein tested the effect of clarithromycin on aldosterone synthesis and secretion in a pure population of aldosterone-secreting cells obtained by immunoseparation (CD56(+) cells) from APA tissues with/without the 2 most common KCNJ5 mutations...
October 9, 2017: Hypertension
https://www.readbyqxmd.com/read/28992276/the-potential-role-of-primary-care-in-case-detection-screening-of-primary-aldosteronism
#11
Gregory A Kline, Ally P H Prebtani, Alexander A Leung, Ernesto L Schiffrin
Endocrine hypertension, particularly primary aldosteronism (PA), was previously considered to account for less than 1% of all hypertension and was suspected only when patients presented with spontaneous hypokalemia. However, the last 20 years of PA research has now clearly shown that PA is not a rarity, but rather, may account for up to 13% of unselected hypertensive individuals and between 10% and 20% of those with resistant hypertension. Most of these patients do not have spontaneous hypokalemia. The population prevalence of PA likely far exceeds actual detection rates in routine clinical care...
June 19, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28991825/evaluation-of-vasopressin-for-septic-shock-in-patients-on-chronic-renin-angiotensin-aldosterone-system-inhibitors
#12
Beth L Erwin, Michael A Denaburg, Andrew B Barker, Philip J McArdle, Samuel T Windham, Charity J Morgan
OBJECTIVES: To compare the hemodynamic response in septic shock patients receiving vasopressin who were on chronic renin-angiotensin-aldosterone system inhibitor therapy with those who were not. DESIGN: Single-center, retrospective cohort study. SETTING: Medical and surgical ICUs at a 1,100-bed academic medical center. PATIENTS: Medical and surgical ICU patients with septic shock who received vasopressin infusion added to at least one concomitant vasopressor agent between January 2014 and December 2015, then divided into two cohorts: 1) patients who were on chronic renin-angiotensin-aldosterone system inhibitor therapy as outpatients and 2) patients who were not on chronic renin-angiotensin-aldosterone system inhibitor therapy as outpatients...
October 6, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28978983/body-mass-index-and-contralateral-ratio-predict-outcome-following-unilateral-adrenalectomy-in-primary-aldosteronism
#13
Kanako Bokuda, Midori Yatabe, Yuki Mizuguchi, Michita Niiyama, Yasufumi Seki, Daisuke Watanabe, Junichi Yatabe, Takashi Ando, Satoshi Morimoto, Atsuhiro Ichihara
The effect of unilateral adrenalectomy on blood pressure (BP) outcome in primary aldosteronism (PA) is diverse. Therefore, we sought to investigate the preoperative factors contributing to postoperative BP outcome. Data for 96 PA patients who underwent unilateral adrenalectomy at our institution from January 2000 to February 2015 were retrospectively collected. Based on postoperative BP after a 12-month follow-up period, the patients were categorized into two groups: cured (C) (<140/90 mm Hg with no antihypertensive drug) and not cured (NC) (if not normotensive)...
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28974781/monozygotic-twins-discordant-for-primary-aldosteronism-a-case-report
#14
Y Kobayashi, K Yatsu, K Nakata-Shimokihara, N Inoue, T Fujikawa, N Hirawa, S Umemura, F Satoh, G P Rossi, K Tamura
This corrects the article DOI: 10.1038/jhh.2017.41.
November 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28974569/old-and-new-concepts-in-the-molecular-pathogenesis-of-primary-aldosteronism
#15
REVIEW
Elke Tatjana Aristizabal Prada, Jacopo Burrello, Martin Reincke, Tracy Ann Williams
No abstract text is available yet for this article.
November 2017: Hypertension
https://www.readbyqxmd.com/read/28974210/hypertension-outcomes-of-adrenalectomy-in-patients-with-primary-aldosteronism-a-systematic-review-and-meta-analysis
#16
Yu Zhou, Meilian Zhang, Sujie Ke, Libin Liu
BACKGROUND: The hypertension cure rate of unilateral adrenalectomy in primary aldosteronism (PA) patients varies widely in existing studies. METHODS: We conducted an observational meta-analysis to summarize the pooled hypertension cure rate of unilateral adrenalectomy in PA patients. Comprehensive electronic searches of PubMed, Embase, Cochrane, China National Knowledge Internet (CNKI), WanFang, SinoMed and Chongqing VIP databases were performed from initial state to May 20, 2016...
October 3, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28973103/genetic-causes-of-functional-adrenocortical-adenomas
#17
Maria-Christina Zennaro, Sheerazed Boulkroun, Fabio Fernandes-Rosa
Aldosterone and cortisol, the main mineralocorticoid and glucocorticoid hormones in humans, are produced in the adrenal cortex, which is composed of three concentric zone with specific functional characteristics. Adrenocortical adenomas (ACA) may lead to the autonomous secretion of aldosterone responsible for primary aldosteronism, the most frequent form of secondary arterial hypertension. In the case of cortisol production, ACA lead to overt or subclinical Cushing syndrome. Genetic analysis driven by next generation sequencing technology has enabled the discovery, during the last seven years, of the genetic causes of a large subset of ACA...
August 2, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28966243/the-aldosterone-receptor-antagonist-eplerenone-inhibits-isoproterenol-induced-collagen-i-and-11%C3%AE-hsd1-expression-in-rat-cardiac-fibroblasts-and-the-left-ventricle
#18
Yasutomo Hori, Daisuke Touei, Ryuta Saitoh, Maki Yamagishi, Kazutaka Kanai, Fumio Hoshi, Naoyuki Itoh
β-Adrenergic receptor (β-AR)-induction of collagen-I synthesis is partially mediated by the cardiac mineralocorticoid receptor (MR) system. However, it remains unclear whether the selective MR antagonist, eplerenone, inhibits collagen-I synthesis induced by β-AR stimulation. We investigated the effects of eplerenone on the responses to a non-selective β-AR agonist, isoproterenol, which induced collagen-I synthesis in primary cardiac fibroblasts (CFs) and the left ventricle. mRNAs encoding the MR and 11β-hydroxysteroid dehydrogenase type I (11β-HSD1) were evident in the left ventricle and primary CFs...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28958958/biological-diagnosis-of-primary-aldosteronism-summary-of-new-french-and-international-guidelines
#19
Damien Denimal, Stéphanie Lemaire, Laurence Duvillard
The biological diagnosis of primary aldosteronism (PA) is a real challenge in clinical laboratories. First, PA is a major cause of secondary hypertension, and more widespread screening is currently recommended. In addition, the recent development of automated and mass spectrometry tests has made it necessary to determine the most appropriate cutoff values in clinical studies. New French and international guidelines will play an important role in the standardization of PA diagnosis. The first diagnostic step is to measure the aldosterone to renin ratio (ARR), which is widely considered the best screening test...
October 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28957852/the-subtyping-of-primary-aldosteronism-by-adrenal-vein-sampling-sequential-blood-sampling-causes-factitious-lateralization
#20
Giacomo Rossitto, Michele Battistel, Giulio Barbiero, Valeria Bisogni, Giuseppe Maiolino, Miotto Diego, Teresa M Seccia, Gian Paolo Rossi
BACKGROUND: The pulsatile secretion of adrenocortical hormones and a stress reaction occurring when starting adrenal vein sampling (AVS) can affect the selectivity and also the assessment of lateralization when sequential blood sampling is used. We therefore tested the hypothesis that a simulated sequential blood sampling could decrease the diagnostic accuracy of lateralization index for identification of aldosterone-producing adenoma (APA), as compared with bilaterally simultaneous AVS...
September 27, 2017: Journal of Hypertension
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