keyword
https://read.qxmd.com/read/38135688/genomic-portrait-and-relatedness-patterns-of-the-iron-age-log-coffin-culture-in-northwestern-thailand
#21
JOURNAL ARTICLE
Selina Carlhoff, Wibhu Kutanan, Adam B Rohrlach, Cosimo Posth, Mark Stoneking, Kathrin Nägele, Rasmi Shoocongdej, Johannes Krause
The Iron Age of highland Pang Mapha, northwestern Thailand, is characterised by a mortuary practice known as Log Coffin culture. Dating between 2300 and 1000 years ago, large coffins carved from individual teak trees have been discovered in over 40 caves and rock shelters. While previous studies focussed on the cultural development of the Log Coffin-associated sites, the origins of the practice, connections with other wooden coffin-using groups in Southeast Asia, and social structure within the region remain understudied...
December 22, 2023: Nature Communications
https://read.qxmd.com/read/38094151/inferring-phylogenetic-structure-taxa-hybridization-and-divergence-times-within-rock-voles-of-subgenus-aschizomys-cricetidae-alticola-using-quaddrad-sequencing-and-a-cytb-dataset
#22
JOURNAL ARTICLE
Ivan A Dvoyashov, Semyon Yu Bodrov, Nikolai V Mamaev, Elena S Glagoleva, Natalia I Abramson
The subgenus Aschizomys belongs to the genus Alticola (Central Asian mountain vole) and consists of two species: Alticola macrotis and Alticola lemminus. Phylogenetic relationships within the subgenus Aschizomys remain obscure due to limited sampling, an insufficient number of molecular markers used in phylogenetic studies, and paraphyly observed on mitochondrial trees. In this work, to infer reliable phylogenetic relationships and evaluate putative scenarios of ancient hybridization within the subgenus, we applied double-digest restriction site-associated DNA paired-end (quaddRAD) sequencing to 20 DNA samples (20 individuals), including five species of the genus Alticola , and dated the divergence of cytochrome b ( cytb ) lineages within Aschizomys using a "second calibration" approach...
December 2023: Ecology and Evolution
https://read.qxmd.com/read/38093387/mrpl48-is-a-novel-prognostic-and-predictive-biomarker-of-hepatocellular-carcinoma
#23
JOURNAL ARTICLE
Yu-Xiang Lin, Jun-Yong Pan, Wen-Du Feng, Tian-Cong Huang, Cheng-Zong Li
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most prevalent forms of cancer and poses a threat to the health and survival of humans. Mitochondrial ribosomal protein L48 (MRPL48) belongs to the mitochondrial ribosomal protein family, which participates in energy production. Studies have shown that MRPL48 can predict osteosarcoma incidence and prognosis, as well as promotes colorectal cancer progression. However, the role of MRPL48 in HCC remains unknown. METHODS: TCGA, GEO, HCCDB, CPTAC, SMART, UALCAN, Kaplan-Meier plotter, cBioPortal, and MethSurv were performed for bioinformatics purposes...
December 14, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38071602/caveolin-1-promotes-mitochondrial-health-and-limits-mitochondrial-ros-through-rock-ampk-regulation-of-basal-mitophagic-flux
#24
JOURNAL ARTICLE
Logan R Timmins, Milene Ortiz-Silva, Bharat Joshi, Y Lydia Li, Fiona H Dickson, Timothy H Wong, Kurt R Vandevoorde, Ivan R Nabi
Caveolin-1 (CAV1), the main structural component of caveolae, is phosphorylated at tyrosine-14 (pCAV1), regulates signal transduction, mechanotransduction, and mitochondrial function, and plays contrasting roles in cancer progression. We report that CRISPR/Cas9 knockout (KO) of CAV1 increases mitochondrial oxidative phosphorylation, increases mitochondrial potential, and reduces ROS in MDA-MB-231 triple-negative breast cancer cells. Supporting a role for pCAV1, these effects are reversed upon expression of CAV1 phosphomimetic CAV1 Y14D but not non-phosphorylatable CAV1 Y14F...
January 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38029540/altered-anterograde-axonal-transport-of-mitochondria-in-cultured-striatal-neurons-of-a-knock-in-mouse-model-of-huntington-s-disease
#25
JOURNAL ARTICLE
Chao Wu, Haoran Yin, Songdi Fu, Hanna Yoo, Min Zhang, Hyokeun Park
Huntington's disease (HD) is a progressive genetic neurodegenerative disease caused by an abnormal expansion of a cytosine-adenine-guanine trinucleotide repeat in the huntingtin gene. One pathological feature of HD is neuronal loss in the striatum. Despite many efforts, mechanisms underlying neuronal loss in HD striatum remain elusive. It was suggested that the mutant huntingtin protein interacts mitochondrial proteins and causes mitochondrial dysfunction in striatal neurons. However, whether axonal transport of mitochondria is altered in HD striatal neurons remains controversial...
November 18, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38016961/microrna-mediated-attenuation-of-branched-chain-amino-acid-catabolism-promotes-ferroptosis-in-chronic-kidney-disease
#26
JOURNAL ARTICLE
Hisakatsu Sone, Tae Jin Lee, Byung Rho Lee, Dan Heo, Sekyung Oh, Sang-Ho Kwon
Chronic kidney disease can develop from kidney injury incident to chemotherapy with cisplatin, which complicates the prognosis of cancer patients. MicroRNAs regulate gene expression by pairing with specific sets of messenger RNAs. Therefore, elucidating direct physical interactions between microRNAs and their target messenger RNAs can help decipher crucial biological processes associated with cisplatin-induced kidney injury. Through intermolecular ligation and transcriptome-wide sequencing, we here identify direct pairs of microRNAs and their target messenger RNAs in the kidney of male mice injured by cisplatin...
November 28, 2023: Nature Communications
https://read.qxmd.com/read/37976411/genetic-landscape-of-pediatric-acute-liver-failure-of-indeterminate-origin
#27
JOURNAL ARTICLE
Dominic Lenz, Lea D Schlieben, Masaru Shimura, Alyssa Bianzano, Dmitrii Smirnov, Robert Kopajtich, Riccardo Berutti, Rüdiger Adam, Denise Aldrian, Ivo Baric, Ulrich Baumann, Neslihan Eksi Bozbulut, Melanie Brugger, Theresa Brunet, Philip Bufler, Birutė Burnytė, Pier Luigi Calvo, Ellen Crushell, Buket Dalgıç, Anibh M Das, Antal Dezsőfi, Felix Distelmaier, Alexander Fichtner, Peter Freisinger, Sven F Garbade, Harald Gaspar, Louise Goujon, Nedim Hadzic, Steffen Hartleif, Bianca Hegen, Maja Hempel, Stephan Henning, Andre Hoerning, Roderick Houwen, Joanne Hughes, Raffaele Iorio, Katarzyna Iwanicka-Pronicka, Martin Jankofsky, Norman Junge, Ino Kanavaki, Aydan Kansu, Sonja Kaspar, Simone Kathemann, Deidre Kelly, Ceyda Tuna Kırsaçlıoğlu, Birgit Knoppke, Martina Kohl, Heike Kölbel, Stefan Kölker, Vassiliki Konstantopoulou, Tatiana Krylova, Zarife Kuloğlu, Alice Kuster, Martin W Laass, Elke Lainka, Eberhard Lurz, Hanna Mandel, Katharina Mayerhanser, Johannes A Mayr, Patrick McKiernan, Patricia McLean, Valerie McLin, Karine Mention, Hanna Müller, Laurent Pasquier, Martin Pavlov, Natalia Pechatnikova, Bianca Peters, Danijela Petković Ramadža, Dorota Piekutowska-Abramczuk, Denisa Pilic, Sanjay Rajwal, Nathalie Rock, Agnès Roetig, René Santer, Wilfried Schenk, Natalia Semenova, Christiane Sokollik, Ekkehard Sturm, Robert W Taylor, Eva Tschiedel, Vaidotas Urbonas, Roser Urreizti, Jan Vermehren, Jerry Vockley, Georg-Friedrich Vogel, Matias Wagner, Wendy van der Woerd, Saskia B Wortmann, Ekaterina Zakharova, Georg Friedrich Hoffmann, Thomas Meitinger, Kei Murayama, Christian Staufner, Holger Prokisch
BACKGROUND AIMS: Pediatric acute liver failure (PALF) is a life-threatening condition. In Europe, main causes are viral infections (12-16%) and inherited metabolic diseases (14-28%). Yet, in up to 50% of cases the underlying etiology remains elusive, challenging clinical management, including liver transplantation. We systematically studied indeterminate PALF cases referred for genetic evaluation by whole-exome sequencing (WES), and analyzed phenotypic and biochemical markers, and the diagnostic yield of WES in this condition...
November 17, 2023: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/37958829/phylogenetics-and-population-genetics-of-the-petrolisthes-lamarckii-p-haswelli-complex-in-china-old-lineage-and-new-species
#28
JOURNAL ARTICLE
Xuefeng Fang, Dong Dong, Mei Yang, Xinzheng Li
Petrolisthes lamarckii (Leach, 1821) and P. haswelli Miers, 1884 are a pair of sister species of porcelain crabs, both of which are common in the intertidal zone of southern China, typically found under rocks and in the crevices of coral reefs. However, the distribution, genetic relationship and diversity of the two species in China have not been rigorously studied. Meanwhile, P. lamarckii is considered as a complex of cryptic species due to their diverse morphological features. In this study, we identified 127 specimens of the P...
October 31, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37949220/interaction-between-the-mitochondrial-adaptor-miro-and-the-motor-adaptor-trak
#29
JOURNAL ARTICLE
Elana E Baltrusaitis, Erika E Ravitch, Adam R Fenton, Tania Perez, Erika L F Holzbaur, Roberto Dominguez
MIRO (mitochondrial Rho GTPase) consists of two GTPase domains flanking two Ca2+ -binding EF-hand domains. A C-terminal transmembrane helix anchors MIRO to the outer mitochondrial membrane, where it functions as a general adaptor for the recruitment of cytoskeletal proteins that control mitochondrial dynamics. One protein recruited by MIRO is TRAK (trafficking kinesin-binding protein), which in turn recruits the microtubule-based motors kinesin-1 and dynein-dynactin. The mechanism by which MIRO interacts with TRAK on the mitochondrial membrane is not well understood...
November 8, 2023: Journal of Biological Chemistry
https://read.qxmd.com/read/37926169/rich2-decreases-the-mitochondrial-number-and-affects-mitochondrial-localization-in-diffuse-low-grade-glioma-related-epilepsy
#30
JOURNAL ARTICLE
Jiarui Zhang, Li Gong, Huayu Zhu, Wei Sun, Jing Tian, Yan Zhang, Qiao Liu, Xiaolan Li, Fuqin Zhang, Shumei Wang, Shaojun Zhu, Dongjing Ding, Wei Zhang, Chen Yang
Epilepsy, a common complication of diffuse low-grade gliomas (DLGGs; diffuse oligodendroglioma and astrocytoma collectively), severely compromises the quality of life of patients. DLGG epileptogenicity may primarily be generated by interactions between the tumor and the neocortex. Neuronal uptake of dysfunctional mitochondria from the extracellular environment can lead to abnormal neuronal discharge. Mitochondrial dysfunction is frequently observed in gliomas that can transmigrate across the plasma membranes...
November 3, 2023: Neurobiology of Disease
https://read.qxmd.com/read/37907768/a-retrospective-cohort-study-evaluating-pregnancy-outcomes-in-women-with-midd
#31
JOURNAL ARTICLE
B Sanchez-Lechuga, M Salvucci, N Ng, B Kinsley, M Hatunic, M Kennelly, J Edwards, A Fleming, B Byrne, M M Byrne
AIMS: The most common pathogenic mitochondrial mutation associated with mitochondrial disease is m.3243A>G. Increased obstetric complications, such as spontaneous abortion, gestational diabetes (GDM), preterm delivery, and preeclampsia, have been reported in women carrying this mutation. We aimed to determine the fetal and maternal outcomes in pregnant women with mitochondrial disease. METHODS: We retrospectively studied the obstetric and perinatal outcomes in 88 pregnancies of 26 women with genetically confirmed mitochondrial disease (m...
October 31, 2023: Acta Diabetologica
https://read.qxmd.com/read/37872005/hiding-on-jagged-karst-pinnacles-a-new-microendemic-genus-and-species-of-a-limestone-dwelling-agamid-lizard-squamata-agamidae-draconinae-from-khammouan-province-laos
#32
JOURNAL ARTICLE
Saly Sitthivong, Peter Brakels, Santi Xayyasith, Nathanaël Maury, Sabira Idiiatullina, Parinya Pawangkhanant, Kai Wang, Tan Van Nguyen, Nikolay A Poyarkov
We describe a unique new species and genus of agamid lizard from the karstic massifs of Khammouan Province, central Laos. Laodracon carsticola Gen. et sp. nov. is an elusive medium-sized lizard (maximum snout-vent length 101 mm) specifically adapted to life on limestone rocks and pinnacles. To assess the phylogenetic position of the new genus amongst other agamids, we generated DNA sequences from two mitochondrial gene fragments (16S rRNA and ND 2) and three nuclear loci ( BDNF , RAG1 and c-mos ), with a final alignment comprising 7 418 base pairs for 64 agamid species...
November 18, 2023: Zoological Research
https://read.qxmd.com/read/37863874/rhoa-balances-microglial-reactivity-and-survival-during-neuroinflammation
#33
JOURNAL ARTICLE
Renato Socodato, Artur Rodrigues-Santos, Joana Tedim-Moreira, Tiago O Almeida, Teresa Canedo, Camila C Portugal, João B Relvas
Microglia are the largest myeloid cell population in the brain. During injury, disease, or inflammation, microglia adopt different functional states primarily involved in restoring brain homeostasis. However, sustained or exacerbated microglia inflammatory reactivity can lead to brain damage. Dynamic cytoskeleton reorganization correlates with alterations of microglial reactivity driven by external cues, and proteins controlling cytoskeletal reorganization, such as the Rho GTPase RhoA, are well positioned to refine or adjust the functional state of the microglia during injury, disease, or inflammation...
October 20, 2023: Cell Death & Disease
https://read.qxmd.com/read/37841030/%C3%AF-another-step-through-the-crux-a-new-microendemic-rock-dwelling-paroedura-squamata-gekkonidae-from-south-central-madagascar
#34
JOURNAL ARTICLE
Costanza Piccoli, Francesco Belluardo, Javier Lobón-Rovira, Ivo Oliveira Alves, Malalatiana Rasoazanany, Franco Andreone, Gonçalo M Rosa, Angelica Crottini
Using an integrative taxonomic approach including genetic and morphological data, we formally describe a new microendemic gecko species belonging to the Paroedurabastardi clade, previously referred to as P.bastardi D. We name this taxon currently known from Anja Reserve and Tsaranoro Valley Forest (south-central Madagascar), as P.manongavato sp. nov. The new species differs from other species of the P.bastardi clade by ≥ 12.4% uncorrected p -distance at the mitochondrial 16S rRNA gene and it forms a monophyletic group in the COI mtDNA phylogenetic tree...
2023: ZooKeys
https://read.qxmd.com/read/37779585/-pelargonium-sidoides-extract-mediates-nephrotoxicity-through-mitochondrial-malfunction-and-cytoskeleton-destabilization
#35
JOURNAL ARTICLE
Ju Young Lee, JuKyung Lee, Sung Ho Lee, Jeong Ho Hwang, Han Na Suh
We investigated the cytotoxic effect of Pelargonium sidoides extract on Madin-Darby canine kidney (MDCK) cells. P. sidoides extract decreased the cell viability in a dose dependent manner (> 0.2%). The extract of P. sidoides decreased the mitochondrial action potential, increased the number of reactive oxygen species (ROS) inside the cell, and caused nicotinamide adenine dinucleotide hydride (NADH) to be released, all of which are signs of mitochondrial dysfunction. The results of unbiased mRNA sequencing showed that 0...
October 2023: Toxicological Research
https://read.qxmd.com/read/37762147/the-complete-mitochondrial-genomes-of-two-rock-scallops-bivalvia-spondylidae-indicate-extensive-gene-rearrangements-and-adaptive-evolution-compared-with-pectinidae
#36
JOURNAL ARTICLE
Fengping Li, Yu Zhang, Tao Zhong, Xin Heng, Tiancheng Ao, Zhifeng Gu, Aimin Wang, Chunsheng Liu, Yi Yang
Different from the diverse family Pectinidae, the Spondylidae is a small group with a single genus that shares the sedentary life habit of cementing themselves to the substrate. However, little information related to the genetic diversity of Spondylidae has been reported. In the present study, the complete mitochondrial genomes of Spondylus versicolor and S. spinosus were sequenced and compared with those of pectinids. The mtDNA of S. versicolor and S. spinosus show similar patterns with respect to genome size, AT content, AT skew, GC skew, and codon usage, and their mitogenomic sizes are longer than most pectinid species...
September 8, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37734382/actuator-a-listeria-inspired-molecular-tool-for-physical-manipulation-of-intracellular-organizations-through-de-novo-actin-polymerization
#37
JOURNAL ARTICLE
Hideki Nakamura, Elmer Rho, Christopher T Lee, Kie Itoh, Daqi Deng, Satoshi Watanabe, Shiva Razavi, Hideaki T Matsubayashi, Cuncheng Zhu, Eleanor Jung, Padmini Rangamani, Shigeki Watanabe, Takanari Inoue
Form and function are often interdependent throughout biology. Inside cells, mitochondria have particularly attracted attention since both their morphology and functionality are altered under pathophysiological conditions. However, directly assessing their causal relationship has been beyond reach due to the limitations of manipulating mitochondrial morphology in a physiologically relevant manner. By engineering a bacterial actin regulator, ActA, we developed tools termed "ActuAtor" that inducibly trigger actin polymerization at arbitrary subcellular locations...
September 2, 2023: Cell Reports
https://read.qxmd.com/read/37660274/a-dual-antioxidative-coating-on-transmucosal-component-of-implant-to-repair-connective-tissue-barrier-for-treatment-of-peri-implantitis
#38
JOURNAL ARTICLE
Dize Li, Xi Tan, Liwen Zheng, Han Tang, Shanshan Hu, Qiming Zhai, Xuan Jing, Panpan Liang, Yuxin Zhang, Qingqing He, Guangyu Jian, Dongqi Fan, Ping Ji, Tao Chen, Hongmei Zhang
Since the microgap between implant and surrounding connective tissue creates the pass of pathogen invasion, sustained pathological stimuli could accelerate macrophage mediated inflammation, therefore affect peri-implant tissue regeneration and aggravate peri-implantitis. As the transmucosal component of implant, the abutment therefore needs to be biofunctionalized to repair gingival barrier. Here, we provided a mussel-bioinspired implant abutment coating containing tannic acid (TA), cerium and minocycline (TA-Ce-Mino)...
September 3, 2023: Advanced Healthcare Materials
https://read.qxmd.com/read/37627592/a-new-quinone-based-inhibitor-of-mitochondrial-complex-i-in-d-conformation-producing-invasion-reduction-and-sensitization-to-venetoclax-in-breast-cancer-cells
#39
JOURNAL ARTICLE
Matías Monroy-Cárdenas, Víctor Andrades, Cristopher Almarza, María Jesús Vera, Jorge Martínez, Rodrigo Pulgar, John Amalraj, Ramiro Araya-Maturana, Félix A Urra
Mitochondrial Complex I plays a crucial role in the proliferation, chemoresistance, and metastasis of breast cancer (BC) cells. This highlights it as an attractive target for anti-cancer drugs. Using submitochondrial particles, we identified FRV-1, an ortho -carbonyl quinone, which inhibits NADH:duroquinone activity in D-active conformation and reduces the 3ADP state respiration dependent on Complex I, causing mitochondrial depolarization, ATP drop, increased superoxide levels, and metabolic remodeling towards glycolysis in BC cells...
August 10, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37615690/lipotoxicity-polarised-macrophage-derived-exosomes-regulate-mitochondrial-fitness-through-miro1-mediated-mitophagy-inhibition-and-contribute-to-type-2-diabetes-development-in-mice
#40
JOURNAL ARTICLE
Jian-Ming Li, Xianyu Li, Lawrence W C Chan, Ruinian Hu, Tian Zheng, Haojie Li, Sijun Yang
AIMS/HYPOTHESIS: Insulin resistance is a major pathophysiological defect in type 2 diabetes and obesity. Numerous experimental and clinical studies have provided evidence that sustained lipotoxicity-induced mitophagy deficiency can exacerbate insulin resistance, leading to a vicious cycle between mitophagy dysfunction and insulin resistance, and thereby the onset of type 2 diabetes. Emerging evidence suggests that exosomes (Exos) from M2 macrophages play an essential role in modulating metabolic homeostasis...
August 24, 2023: Diabetologia
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