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https://www.readbyqxmd.com/read/27936178/ex-vivo-lung-perfusion-in-the-rat-detailed-procedure-and-videos
#1
Giulia Alessandra Bassani, Caterina Lonati, Daniela Brambilla, Francesca Rapido, Franco Valenza, Stefano Gatti
Ex vivo lung perfusion (EVLP) is a promising procedure for evaluation, reconditioning, and treatment of marginal lungs before transplantation. Small animal models can contribute to improve clinical development of this technique and represent a substantial platform for bio-molecular investigations. However, to accomplish this purpose, EVLP models must sustain a prolonged reperfusion without pharmacological interventions. Currently available protocols only partly satisfy this need. The aim of the present research was accomplishment and optimization of a reproducible model for a protracted rat EVLP in the absence of anti-inflammatory treatment...
2016: PloS One
https://www.readbyqxmd.com/read/27935911/giant-left-atrium-a-rare-case-of-acute-upper-gastrointestinal-bleeding
#2
K R Dewan, B S Patowary, S Bhattarai
Acute upper GI bleeding is a common medical emergency with a hospital mortality of approximately 10%. Non variceal UGI bleeding is the most common cause followed by oesophageal varices. Various rare causes have been described in the literature but there are very few cases of giant left atrium leading to oesophageal erosion and causing upper GI bleeding. We are presenting a case of rheumatic valvular heart disease with giant left atrium who presented in our department with acute upper GI bleeding.
January 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935359/microsurgical-and-endoscopic-approaches-to-the-pulvinar
#3
Osamu Akiyama, Ken Matsushima, Abuzer Gungor, Satoshi Matsuo, Dylan J Goodrich, R Shane Tubbs, Paul Klimo, Aaron A Cohen-Gadol, Hajime Arai, Albert L Rhoton
OBJECTIVE Approaches to the pulvinar remain challenging because of the depth of the target, surrounding critical neural structures, and complicated arterial and venous relationships. The purpose of this study was to compare the surgical approaches to different parts of the pulvinar and to examine the efficacy of the endoscope as an adjunct to the operating microscope in this area. METHODS The pulvinar was examined in 6 formalin-fixed human cadaveric heads through 5 approaches: 4 above and 1 below the tentorium...
December 9, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27935171/revisiting-thoracic-surface-anatomy-in-an-adult-population-a-ct-evaluation-of-vertebral-level
#4
Masroor Badshah, Roger Soames, Muhammad Jaffar Khan, Muhammad Ibrahim Marwat, Adnan Khan
INTRODUCTION: To compare key thoracic anatomical surface landmarks between healthy and patient adult populations using Computed Tomography (CT). MATERIALS AND METHODS: Sixteen slice CT images of 250 age and gender matched healthy individuals and 99 patients with lung parenchymal disease were analyzed to determine the relationship of 17 thoracic structures and their vertebral levels using a 32-bit Radiant DICOM viewer. The structures studied were: aortic hiatus, azygos vein, brachiocephalic artery, gastroesophageal junction, left and right common carotid arteries, left and right subclavian arteries, pulmonary trunk bifurcation, superior vena cava junction with the right atrium, carina, cardiac apex, manubriosternal junction, xiphisternal joint, inferior vena cava (IVC) crossing the diaphragm, aortic arch and junction of brachiocephalic veins...
December 9, 2016: Clinical Anatomy
https://www.readbyqxmd.com/read/27933393/prevalence-and-prognostic-impact-of-left-sided-valve-thickening-in-systemic-light-chain-amyloidosis
#5
Dania Mohty, Sarah Pradel, Julien Magne, Bahaa Fadel, Cyrille Boulogne, Vincent Petitalot, Safaa Raboukhi, Nicole Darodes, Thibaud Damy, Victor Aboyans, Arnaud Jaccard
BACKGROUND: Left heart valve thickening (LVT) was described in patients with light-chain amyloidosis (AL). This phenomenon reflects likely infiltration of the valve by amyloid proteins. However, the prevalence of LVT and its prognostic value have not been investigated in patients with AL. METHODS AND RESULTS: Comprehensive transthoracic echocardiography was performed at baseline in 150 patients [median age 68 (33-87) years; 59% male] with confirmed AL. The presence of abnormal mitral and/or aortic valve thickening (>3 mm) was assessed in all included patients...
December 8, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27930718/seeing-the-invisible-revealing-atrial-ablation-lesions-using-hyperspectral-imaging-approach
#6
Narine Muselimyan, Luther M Swift, Huda Asfour, Tigran Chahbazian, Ramesh Mazhari, Marco A Mercader, Narine A Sarvazyan
BACKGROUND: Currently, there are limited means for high-resolution monitoring of tissue injury during radiofrequency ablation procedures. OBJECTIVE: To develop the next generation of visualization catheters that can reveal irreversible atrial muscle damage caused by ablation and identify viability gaps between the lesions. METHODS: Radiofrequency lesions were placed on the endocardial surfaces of excised human and bovine atria and left ventricles of blood perfused rat hearts...
2016: PloS One
https://www.readbyqxmd.com/read/27930603/strategies-to-improve-the-efficacy-of-epicardial-linear-ablation-on-the-beating-heart
#7
Yoshiyuki Watanabe, Matthew R Schill, Toshinobu Kazui, Spencer J Melby, Richard B Schuessler, Ralph J Damiano
OBJECTIVE: Creating transmural linear lesions on the beating heart is an important component of minimally invasive surgical ablation for atrial fibrillation. Animal studies have shown poor efficacy for surface bipolar radiofrequency ablation (RFA). Clinicians have developed strategies including multiple device applications and vena caval occlusion (VCO) to improve ablation efficacy. These techniques were evaluated in an acute porcine model. METHODS: In the first experiment, an RFA device was used to perform two 40-second epicardial ablations on the right atrium of six pigs...
December 7, 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27928478/leiomyosarcoma-of-inferior-vena-cava-and-right-atrium-with-ascites-and-jaundice-a-case-report
#8
Roshanak Hasheminasab Zavareh, Hassan Riahi Beni, Aida Iranpour, Mojgan Alam Samimi, Alireza Sadeghipour, Seyedeh Nina Alavi Niakou
Leiomyosarcoma is one of the soft tissue sarcomas that could originate from different parts of body and are mostly presented as retropritoneal mass. Leiomyosarcomas of vascular origin are particularly rare tumors occurring mainly in inferior vena cava (IVC). Here, we report the case of a 35-year-old male patient who presented with ascites and jaundice. Further evaluation revealed large hepatic and cardiac masses with extension to IVC. Since it was not possible to determine the point of origin of leiomyosarcoma, the patient received chemotherapy under diagnosis of metastatic leiomyosarcoma but unfortunately passed away...
October 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27928261/iatrogenic-diversion-of-inferior-vena-cava-into-left-atrium-after-surgery-for-a-rare-combination-of-congenital-heart-diseases
#9
Feridoun Sabzi
Atrial septal defect (ASD) is a common congenital anomaly that has low surgical mortality and morbidity. We report a very rare case of a low-lying ASD, combined with the drainage of the inferior vena cava and the left superior vena cava into the left atrium. This combination was associated with an unroofed coronary sinus. We also describe an iatrogenic surgical diversion of the inferior vena cava into the left atrium with its complication. The patient presented with moderate cyanosis and was referred for elective ASD repair...
April 13, 2016: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/27925659/impaired-left-atrial-conduit-function-in-coronary-artery-disease-patients-with-poorly-controlled-diabetes-two-dimensional-speckle-tracking-echocardiographic-study
#10
Ali Hosseinsabet, Reza Mohseni-Badalabadi, Ali Moinfar
OBJECTIVES: The myocardium can be affected by diabetes mellitus. The effects of blood glucose control on some organs such as the kidney and eye have been previously reported. The aim of our study was to evaluate left atrial function via 2-dimensional (2D) speckle-tracking echocardiography in a group of coronary artery disease (CAD) patients with well-controlled diabetes (hemoglobin A1c [HbA1c] < 7%) and to compare it with that in a group of CAD patients with poorly controlled diabetes...
November 28, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27925338/transient-restoration-of-the-electrical-conduction-between-the-left-atrium-and-coronary-sinus-musculature
#11
Jeong-Wook Park, Young-Woong Ha, Sung-Hwan Kim, Yong-Seog Oh
No abstract text is available yet for this article.
December 7, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27924218/sex-related-differences-in-the-associations-between-plasma-free-fatty-acid-levels-and-clinical-features-in-patients-with-hypertrophic-cardiomyopathy
#12
Chengzhi Yang, Changlin Zhang, Jiansong Yuan, Jingang Cui, Shengwen Liu, Fenghuan Hu, Weixian Yang, Xuanye Bi, Shubin Qiao
BACKGROUND: Previous studies have indicated that inefficient energy utilization may play a pivotal role in hypertrophic cardiomyopathy (HCM). However, whether plasma free fatty acid (FFA), a main energy substrate of heart, has an effect on HCM remains unclear. Besides, several studies have suggested sex-related differences in HCM features and FFA metabolism. Here, we aimed to explore the association between plasma FFA levels and HCM and potential effects of sex on this relation. METHODS: A total of 412 patients (age 47...
2016: Biology of Sex Differences
https://www.readbyqxmd.com/read/27923400/allele-specific-expression-in-the-human-heart-and-its-application-to-postoperative-atrial-fibrillation-and-myocardial-ischemia
#13
Martin I Sigurdsson, Louis Saddic, Mahyar Heydarpour, Tzuu-Wang Chang, Prem Shekar, Sary Aranki, Gregory S Couper, Stanton K Shernan, Jon G Seidman, Simon C Body, Jochen D Muehlschlegel
BACKGROUND: Allele-specific expression (ASE) is differential expression of each of the two chromosomal alleles of an autosomal gene. We assessed ASE patterns in the human left atrium (LA, n = 62) and paired samples from the left ventricle (LV, n = 76) before and after ischemia, and tested the utility of differential ASE to identify genes associated with postoperative atrial fibrillation (poAF) and myocardial ischemia. METHODS: Following genotyping from whole blood and whole-genome sequencing of LA and LV samples, we called ASE using sequences overlapping heterozygous SNPs using rigorous quality control to minimize false ASE calling...
December 6, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27922120/regulation-of-human-cardiac-potassium-channels-by-full-length-kcne3-and-kcne4
#14
Geoffrey W Abbott
Voltage-gated potassium (Kv) channels comprise pore-forming α subunits and a multiplicity of regulatory proteins, including the cardiac-expressed and cardiac arrhythmia-linked transmembrane KCNE subunits. After recently uncovering novel, N-terminally extended (L) KCNE3 and KCNE4 isoforms and detecting their transcripts in human atrium, reported here are their functional effects on human cardiac Kv channel α subunits expressed in Xenopus laevis oocytes. As previously reported for short isoforms KCNE3S and KCNE4S, KCNE3L inhibited hERG; KCNE4L inhibited Kv1...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27920828/detection-of-sequential-activation-of-left-atrium-and-coronary-sinus-musculature-in-the-general-population
#15
Masaki Ota, Yoshiaki Kaneko, Tadashi Nakajima, Tadanobu Irie, Takafumi Iijima, Akihiro Saito, Masahiko Kurabayashi
BACKGROUND: The direction of impulse propagation across the coronary sinus (CS) musculature (CSM) is an important piece of the mechanistic puzzle underlying atrial tachyarrhythmias. We hypothesized that in the general population, the sequence of left atrial (LA) to CSM electrograms recorded in the CS reflects the direction of impulse propagation over the CSM. METHODS: We studied 19 patients with atrioventricular (AV) reentrant tachycardia (RT) utilizing a left-sided accessory pathway (AP) and 21 patients with typical counterclockwise atrial flutter (AFL)...
December 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27920691/primary-leiomyosarcoma-in-the-inferior-vena-cava-extended-to-the-right-atrium-a-case-report-and-review-of-the-literature
#16
Shuichi Fujita, Hideaki Takahashi, Yumiko Kanzaki, Tomohiro Fujisaka, Yoshihiro Takeda, Hideki Ozawa, Hiroko Kuwabara, Takahiro Katsumata, Nobukazu Ishizaka
A 38-year-old woman had developed an abdominal distention, lower extremity edema, and dyspnea. Imaging examination revealed a large mass in the right atrium which was connected to lesions within the inferior vena cava. Although complete resection of the mass was not possible, partial surgical tumor resection was performed to avoid pulmonary embolization and circulatory collapse. Leiomyosarcoma was diagnosed histologically, and chemotherapy (doxorubicin) followed by radiotherapy was started. By reviewing papers published in the past 10 years that included 322 patients, we also discuss the clinical presentations and prognosis of leiomyosarcoma in the inferior vena cava...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27920463/giant-left-atrium-back-to-basic-chest-x-ray-interpretation
#17
G C Colin, T Kirchgesner, D Vancraeynest, B Ghaye
No abstract text is available yet for this article.
2016: Acta Cardiologica
https://www.readbyqxmd.com/read/27920021/venous-and-arterial-air-embolism-a-rare-phenomenon-with-fatal-consequences
#18
Jatan Shah, Nasheena Jiwa, Natasha Mamdani, David Hill
Air embolism is often an iatrogenic complication which may occur in venous or arterial circulation depending on the port of entry. We present two cases in which air embolism occurred in venous and arterial circulation after contrast medium injection (CMI) and coronary artery bypass graft (CABG) surgery, respectively. In one case, accumulation of air bubbles was observed in the pulmonary artery after CMI. This was attributed to inadvertent injection of air owing to improper connection of the injector and the catheter...
December 5, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27919764/postoperative-atrial-tachycardias-following-mitral-valve-surgery-mechanisms-and-outcomes-of-catheter-ablation
#19
Andres Enriquez, Pasquale Santangeli, Erica Zado, Jackson Liang, Simon Castro, Fermin Garcia, Robert Schaller, Gregory Supple, David Frankel, David Callans, David Lin, Sanjay Dixit, Rajat Deo, Michael Riley, Francis Marchlinski
BACKGROUND: Atrial tachycardias (ATs) including atrial fibrillation (AF) are common arrhythmias late after mitral valve (MV) surgery and their management is challenging. OBJECTIVE: To determine the electrophysiological mechanisms of ATs in patients with prior MV surgery and the long-term outcomes of catheter ablation. METHODS: We studied 67 consecutive patients (age 59.4±10.6 years, 41 male) with a history of MV surgery who presented with ATs post-operatively between 2007-2015...
December 2, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27919724/reference-levels-for-central-venous-pressure-and-pulmonary-artery-occlusion-pressure-monitoring-in-the-lateral-position
#20
In-Kyung Song, Soohan Ro, Ji-Hyun Lee, Eun-Hee Kim, Hee-Soo Kim, Jae-Hyon Bahk, Jin-Tae Kim
OBJECTIVE: To investigate reference levels for central venous pressure or pulmonary artery occlusion pressure monitoring in a lateral position. DESIGN: Retrospective observational study. SETTING: A tertiary university hospital. PARTICIPANTS: A total of 204 adults who underwent chest computed tomography scan in the 90° lateral position from November 2006 to February 2015. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Distances from the mid-sternum to the uppermost and lowermost blood levels of both atria were measured...
September 13, 2016: Journal of Cardiothoracic and Vascular Anesthesia
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