keyword
MENU ▼
Read by QxMD icon Read
search

viral vaccine

keyword
https://www.readbyqxmd.com/read/27906032/infection-of-rhesus-macaques-with-a-pool-of-simian-immunodeficiency-virus-with-the-envelope-genes-from-acute-hiv-1-infections
#1
Kendall C Krebs, Meijuan Tian, Mohammed Asmal, Binhua Ling, Kenneth Nelson, Kenneth Henry, Richard Gibson, Yuejin Li, Weining Han, Robin J Shattock, Ronald S Veazey, Norman Letvin, Eric J Arts, Yong Gao
BACKGROUND: New simian-human immunodeficiency chimeric viruses with an HIV-1 env (SHIVenv) are critical for studies on HIV pathogenesis, vaccine development, and microbicide testing. Macaques are typically exposed to single CCR5-using SHIVenv which in most instances does not reflect the conditions during acute/early HIV infection (AHI) in humans. Instead of individual and serial testing new SHIV constructs, a pool of SHIVenv_B derived from 16 acute HIV-1 infections were constructed using a novel yeast-based SHIV cloning approach and then used to infect macaques...
November 25, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27903801/inhibition-of-an-aquatic-rhabdovirus-demonstrates-promise-of-a-broad-spectrum-antiviral-for-use-in-aquaculture
#2
Bethany F Balmer, Rachel L Powers, Ting-Hu Zhang, Jihye Lee, Frederic Vigant, Benhur Lee, Michael E Jung, Maureen K Purcell, Kevin Snekvik, Hector C Aguilar
: Many enveloped viruses cause devastating disease in aquaculture, resulting in significant economic impact. LJ001 is a broad-spectrum antiviral compound that inhibits enveloped viral infections by specifically targeting phospholipids in the lipid bilayer via production of singlet oxygen ((1)O2). This stabilizes positive curvature and decreases membrane fluidity, which inhibits viral-cell membrane fusion during viral entry. Based on previous mammalian studies and the requirement of light for activation of LJ001, we hypothesized that LJ001 may be useful as a preventative and/or therapeutic agent for enveloped viral infections in aquaculture...
November 30, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27903416/post-licensure-phase-iv-safety-study-of-a-live-attenuated-japanese-encephalitis-recombinant-vaccine-in-children-in-thailand
#3
Tawee Chotpitayasunondh, Pornpimol Pruekprasert, Thanyawee Puthanakit, Chitsanu Pancharoen, Auchara Tangsathapornpong, Peninnah Oberdorfer, Pope Kosalaraksa, Olarn Prommalikit, Suwimon Tangkittithaworn, Phirangkul Kerdpanich, Chonnamet Techasaensiri, Joanna Korejwo, Sunate Chuenkitmongkol, Guy Houillon
BACKGROUND: Japanese encephalitis is a mosquito-borne viral disease endemic in most countries in Asia. A recombinant live, attenuated Japanese encephalitis virus vaccine, JE-CV, is licensed in 14 countries, including Thailand, for the prevention of Japanese encephalitis in adults and children. METHODS: This was a prospective, phase IV, open-label, multicentre, safety study of JE-CV conducted from November 2013 to April 2015, to evaluate rare serious adverse events (AEs)...
November 28, 2016: Vaccine
https://www.readbyqxmd.com/read/27902915/characterization-of-chicken-splenic-derived-dendritic-cells-following-vaccine-and-very-virulent-strains-of-infectious-bursal-disease-virus-infection
#4
A R Yasmin, S K Yeap, M Hair-Bejo, A R Omar
Studies have shown that infectious bursal disease virus (IBDV) infects lymphoid cells, mainly B cells and macrophages. This study was aimed to examine the involvement of chicken splenic-derived dendritic cells (ch-sDCs) in specific-pathogen-free chickens following inoculation with IBDV vaccine strain (D78) and a very virulent (vv) strain (UPM0081). Following IBDV infection, enriched activated ch-sDCs were collected by using the negative selection method and were examined based on morphology and immunophenotyping to confirm the isolation method for dendritic cells (DCs)...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27902909/marek-s-disease-in-backyard-chickens-a-study-of-pathologic-findings-and-viral-loads-in-tumorous-and-nontumorous-birds
#5
Aslı Mete, Radhika Gharpure, Maurice E Pitesky, Dan Famini, Karen Sverlow, John Dunn
Marek's disease (MD) is a major cause of mortality in backyard chickens. The diagnosis of MD is complex, however, and knowledge of Marek's disease virus (MDV) in spontaneous field cases such as in backyard chickens is largely unknown. In this study, 40 backyard chickens with a presumptive MD diagnosis based on histologic lymphoid infiltrations in peripheral nerves with and without lymphomas were investigated. Twenty-eight of the birds were submitted to the diagnostic laboratory for disease explorations, and 12 chickens were from a flock in which some members demonstrated anisocoria and pupil irregularities compatible with ocular MD...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27902409/prevention-of-herpes-zoster-and-its-complications-from-the-clinic-to-the-real-life-experience-with-the-vaccine
#6
Giovanni Gabutti, Nicoletta Valente, Parvanè Kuhdari, Silvia Lupi, Armando Stefanati
The Herpes Zoster (HZ) is an acute viral illness characterized by a vesicular rash, with unilateral distribution, which can eventually cause severe complications, such as the post-herpetic neuralgia (PHN), the ophthalmic zoster, stroke or other neurological complications. In Europe, an incidence between 2.0 and 4.6 cases per 1,000 persons-year is estimated, with an increase after 50 years of age. Currently, the therapeutic options for HZ are only partially effective to limit the acute phase, while the management of complications is frequently complex and not satisfactory...
November 4, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902386/establishment-of-memory-cd8-t-cells-with-live-attenuated-influenza-virus-laiv-across-different-vaccination-doses
#7
Zhongfang Wang, Lukasz Kedzierska, Simone Nuessing, Brendon Chua, Sergio M Quiñones-Parra, Victor C Huber, David Jackson, Paul G Thomas, Katherine Kedzierska
FluMist has been used in children and adults for more than ten years. As pre-existing CD8+ T-cell memory pools can provide heterologous immunity against distinct influenza viruses, it is important to understand influenza-specific CD8+ T-cell responses elicited by different LAIV regimens. In this study, we immunized mice intranasally (i.n.) with two different doses of live-attenuated PR8 virus (PR8 ts, H1N1), low and high, and then assessed protective efficacy by challenging animals with heterosubtypic X31-H3N2 virus at 6 weeks post-vaccination...
November 2, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27902382/the-genetic-diversity-and-phenotypic-associations-of-feline-caliciviruses-from-cats-in-switzerland
#8
Andrea M Spiri, Julien Thézé, Marina L Meli, Valentino Cattori, Alice Berger, Adolf Steinrigl, Oliver G Pybus, Regina Hofmann-Lehmann, Barbara Willi
Feline calicivirus (FCV) is a common viral pathogen in domestic cats worldwide. The variable regions of the capsid (VP1) gene of FCV have one of the highest recorded rates of molecular evolution. Understanding the genetic diversity and phylogeny of FCV is a prerequisite to exploring the epidemiology and pathogenesis of this virus and to the development of efficacious vaccine strategies. In this study, we undertook a nationwide molecular characterization of FCV using for the first time nearly complete capsid (VP1) gene sequences...
October 7, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27902344/pre-infection-transcript-levels-of-fam26f-in-pbmcs-inform-about-overall-plasma-viral-load-in-acute-and-postacute-phase-after-siv-infection
#9
Aneela Javed, Nicole Leuchte, Gabriela Salinas, Lennart Opitz, Christiane Stahl-Hennig, Sieghart Sopper, Ulrike Sauermann
CD8+ cells from simian immunodeficiency virus (SIV)-infected long-term non-progressors and some uninfected macaques can suppress viral replication in vitro without killing the infected cells. The aim of the study was to identify factors responsible for non-cytolytic viral suppression by transcriptional profiling and to investigate their potential impact on SIV-replication. Results of microarray experiments and further validation with cells from infected and uninfected macaques revealed that FAM26F RNA levels distinguished CD8+ cells of controllers and non-controllers (p=0...
October 18, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27902330/simian-immunodeficiency-virus-sivmac239-infection-and-simian-human-immunodeficiency-virus-shiv89-6p-infection-result-in-progression-to-aids-in-cynomolgus-macaques-from-asian-country-origin
#10
Tomotaka Okamura, Yusuke Tsujimura, Shogo Soma, Ichiro Takahashi, Kazuhiro Matsuo, Yasuhiro Yasutomi
Simian immunodeficiency virus (SIV) infection models in cynomolgus macaques are important for analysis of the pathogenesis of immunodeficiency virus and for studies on the efficacy of new vaccine candidates. However, very little is known about the pathogenesis of SIV or simian human immunodeficiency virus (SHIV) in cynomolgus macaques from different Asian country origins. In the present study, we analyzed the infectivity and pathogenicity of CCR5-tropic SIVmac and those of dual-tropic SHIV89.6P inoculated in cynomolgus macaques of Indonesia, Malaysia or Philippines origin...
October 21, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27902312/genetic-mutations-in-live-infectious-bronchitis-vaccine-viruses-following-single-or-dual-in-vitro-infection-of-tracheal-organ-cultures
#11
Christopher Ball, Sarah Bennett, Anne Forrester, Kannan Ganapathy
Despite regular co-vaccination of two different strains of live infectious bronchitis vaccine viruses, little is known about possible mutations in these viruses following vaccination. As an alternative to chicks, this study used an in-vitro infection model to identify single nucleotide polymorphisms (SNPs) within the part-S1 gene of two live IBV vaccine strains (793B and Massachusetts) following single or dual inoculation onto tracheal organ cultures (TOCs). Results indicate that viral titres reduced over the duration of the study, conversely the amount of detected IBV genome increased...
October 12, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27901019/additives-for-vaccine-storage-to-improve-thermal-stability-of-adenoviruses-from-hours-to-months
#12
Maria Pelliccia, Patrizia Andreozzi, Jayson Paulose, Marco D'Alicarnasso, Valeria Cagno, Manuela Donalisio, Andrea Civra, Rebecca M Broeckel, Nicole Haese, Paulo Jacob Silva, Randy P Carney, Varpu Marjomäki, Daniel N Streblow, David Lembo, Francesco Stellacci, Vincenzo Vitelli, Silke Krol
Up to 80% of the cost of vaccination programmes is due to the cold chain problem (that is, keeping vaccines cold). Inexpensive, biocompatible additives to slow down the degradation of virus particles would address the problem. Here we propose and characterize additives that, already at very low concentrations, improve the storage time of adenovirus type 5. Anionic gold nanoparticles (10(-8)-10(-6) M) or polyethylene glycol (PEG, molecular weight ∼8,000 Da, 10(-7)-10(-4) M) increase the half-life of a green fluorescent protein expressing adenovirus from ∼48 h to 21 days at 37 °C (from 7 to >30 days at room temperature)...
November 30, 2016: Nature Communications
https://www.readbyqxmd.com/read/27899444/antigen-dependent-competition-shapes-the-local-repertoire-of-tissue-resident-memory-cd8-t-cells
#13
Andreas Muschaweckh, Veit R Buchholz, Anne Fellenzer, Christian Hessel, Paul-Albert König, Sha Tao, Ronny Tao, Mathias Heikenwälder, Dirk H Busch, Thomas Korn, Wolfgang Kastenmüller, Ingo Drexler, Georg Gasteiger
Tissue-resident memory CD8(+) T cells (TRM) constitute a major component of the immune-surveillance system in nonlymphoid organs. Local, noncognate factors are both necessary and sufficient to support the programming of TRM cell fate in tissue-infiltrating T cells. Recent evidence suggests that TCR signals received in infected nonlymphoid tissues additionally contribute to TRM cell formation. Here, we asked how antigen-dependent pathways influence the generation of skin-resident memory T cells that arise from a polyclonal repertoire of cells induced by infection with an antigenically complex virus and recombinant vaccine vector...
November 29, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27899228/the-recombinant-n-terminal-domain-of-spike-proteins-is-a-potential-vaccine-against-middle-east-respiratory-syndrome-coronavirus-mers-cov-infection
#14
Lan Jiaming, Yao Yanfeng, Deng Yao, Hu Yawei, Bao Linlin, Huang Baoying, Yan Jinghua, George F Gao, Qin Chuan, Tan Wenjie
The persistent public health threat of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the need for an effective MERS-CoV vaccine. Previous studies have focused mainly on the receptor-binding domain (RBD) on the spike protein of MERS-CoV. Herein, we investigated the immunogenicity and protective potential of the recombinant N-terminal domain (rNTD) of spike proteins as a vaccine candidate. BALB/c mice vaccinated with 5 or 10μg of rNTD protein demonstrated a significant humoral immune response (serum IgG and neutralizing activity)...
November 26, 2016: Vaccine
https://www.readbyqxmd.com/read/27899226/virospot-microneutralization-assay-for-antigenic-characterization-of-human-influenza-viruses
#15
Carel A van Baalen, Rienk E Jeeninga, Germaine H W M Penders, Brenda van Gent, Ruud van Beek, Marion P G Koopmans, Guus F Rimmelzwaan
The hemagglutination inhibition (HI) assay has been used for the antigenic characterization of influenza viruses for decades. However, the majority of recent seasonal influenza A viruses of the H3N2 subtype has lost the capacity to agglutinate erythrocytes of various species. The hemagglutination (HA) activity of other A(H3N2) strains is generally sensitive to the action of the neuraminidase inhibitor oseltamivir, which indicates that the neuraminidase and not the hemagglutinin is responsible for the HA activity...
November 26, 2016: Vaccine
https://www.readbyqxmd.com/read/27898919/altering-the-time-of-vaccination-against-respiratory-pathogens-to-enhance-antibody-response-and-performance-of-feeder-cattle
#16
K D Lippolis, R F Cooke, K M Schubach, A P Brandão, L G T da Silva, R S Marques, D W Bohnert
Ninety Angus × Hereford calves were ranked by sex, BW, and age and assigned to 1 of 3 vaccination schemes against the bovine respiratory disease complex: 1) vaccination at weaning (d 0) and a booster at feedlot entry (d 30; CON; = 30), 2) vaccination 15 d before weaning (d -15) and a booster 15 d before feedlot entry (d 15; EARLY; = 30), and 3) vaccination 15 d after weaning (d 15) and a booster 15 d after feedlot entry (d 45; DELAYED; = 30). From d -15 to 7, calves were maintained as a single group on pasture...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898721/hepatitis-b-virus-infections-and-associated-factors-among-pregnant-women-attending-antenatal-care-clinic-at-deder-hospital-eastern-ethiopia
#17
Abdi Umare, Berhanu Seyoum, Tesfaye Gobena, Tamirat Haile Mariyam
BACKGROUND: Hepatitis B virus (HBV) infection is a serious public health problem worldwide. Reports have shown that 68,600 people die of HBV infection and more than 300,000 deaths due to liver cancer secondary to hepatitis B every year globally. Women who are infected with HBV can vertically transmit the infection to their infants. This study aims to determine the prevalence of HBV infection and associated factors among pregnant women. METHODS AND FINDINGS: A hospital-based cross-sectional study was conducted among pregnant women who attended antenatal care clinic (ANC) for routine pregnancy check-up between 18 March 2015 and 15 May 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27898045/dendritic-cell-based-immunotherapies-to-fight-hiv-how-far-from-a-success-story-a-systematic-review-and-meta-analysis
#18
REVIEW
Antonio Victor Campos Coelho, Ronald Rodrigues de Moura, Anselmo Jiro Kamada, Ronaldo Celerino da Silva, Rafael Lima Guimarães, Lucas André Cavalcanti Brandão, Luiz Cláudio Arraes de Alencar, Sergio Crovella
The scientific community still faces the challenge of developing strategies to cure HIV-1. One of these pursued strategies is the development of immunotherapeutic vaccines based on dendritic cells (DCs), pulsed with the virus, that aim to boost HIV-1 specific immune response. We aimed to review DCs-based therapeutic vaccines reports and critically assess evidence to gain insights for the improvement of these strategies. We performed a systematic review, followed by meta-analysis and meta-regression, of clinical trial reports...
November 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27897452/characterization-of-two-recombinant-hvt-ibd-vaccines-by-vp2-insert-detection-and-cell-mediated-immunity-after-vaccination-of-specific-pathogen-free-chickens
#19
Fiona Ingrao, Fabienne Rauw, Thierry van den Berg, Bénédicte Lambrecht
Infectious bursal disease (IBD) is an avian viral disease that causes severe economic losses in the poultry industry worldwide. The live IBD virus (IBDV) has a potential immunosuppressive effect. Currently available IBDV vaccines have shortcomings, prompting the development of safer and more effective vaccination approaches, including the use of the recombinant turkey herpesvirus vaccine expressing the immunogenic structural VP2 protein of IBDV (rHVT-IBD). The objectives of this study were twofold: (i) to develop in vitro assays and molecular tools to detect the VP2 protein and gene, and (ii) to evaluate cell-mediated immunity (CMI) induced by rHVT-IBD vaccination of day-old specific pathogen-free chickens...
November 29, 2016: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/27897109/effect-of-the-modification-of-p24-peptide-antigen-on-dendritic-cell-uptake-and-t-cell-activation
#20
P L Smith, K J Norgate, E Hegarty, N Grageda, E Heelas, M Sommerfelt, T Lange, Arnt-Ove Hovden, B Sørenson, A Dalgleish, M Bodman-Smith
BACKGROUND: Vacc-4x is a candidate therapeutic vaccine consisting of 4 modified peptides based on conserved regions of HIV-1 p24Gag. Vacc4x has been shown to induce long term cellular immunity in immunized infected individuals resulting a reduction in viral load on treatment interruption. OBJECTIVE: Vacc-4x peptides are modified. In this study the effect of modification on uptake of the peptides into PBMC, their subsequent presentation and antigenicity was tested...
November 29, 2016: Current HIV Research
keyword
keyword
85734
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"