Verena E Metz, G Thomas Ray, Vanessa Palzes, Ingrid Binswanger, Andrea Altschuler, Ruchir N Karmali, Brian K Ahmedani, Susan E Andrade, Joseph A Boscarino, Robin E Clark, Irina V Haller, Rulin C Hechter, Douglas W Roblin, Katherine Sanchez, Steffani R Bailey, Dennis McCarty, Kari A Stephens, Carmen L Rosa, Andrea L Rubinstein, Cynthia I Campbell
BACKGROUND: In response to the opioid crisis in the United States, population-level prescribing of opioids has been decreasing; there are concerns, however, that dose reductions are related to potential adverse events. OBJECTIVE: Examine associations between opioid dose reductions and risk of 1-month potential adverse events (emergency department (ED) visits, opioid overdose, benzodiazepine prescription fill, all-cause mortality). DESIGN: This observational cohort study used electronic health record and claims data from eight United States health systems in a prescription opioid registry (Clinical Trials Network-0084)...
November 6, 2023: Journal of General Internal Medicine