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https://www.readbyqxmd.com/read/27899973/expression-patterns-of-maspin-and-mutant-p53-are-associated-with-the-development-of-gestational-trophoblastic-neoplasia
#1
Pengming Sun, Qibin Wu, Guanyu Ruan, Xiu Zheng, Yiyi Song, Jianfan Zhun, Lixiang Wu, Walter H Gotlieb
Gestational trophoblastic disease (GTD) is a group of conditions that originate from the abnormal proliferation of trophoblastic cells. GTDs encompass hydatidiform moles (HMs) and gestational trophoblastic neoplasia (GTN). GTNs are a group of malignant diseases that require chemotherapy, or more aggressive treatment. There is a requirement for more tumor markers to predict the development of GTN from HMs. The current study evaluated the expression of maspin and tumor protein p53 (p53) in GTD, and their role in predicting the development of GTN...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27819410/comparing-and-evaluating-the-efficacy-of-methotrexate-and-actinomycin-d-as-first-line-single-chemotherapy-agents-in-low-risk-gestational-trophoblastic-disease
#2
Young Jae Lee, Jeong Yeol Park, Dae Yeon Kim, Dae Shik Suh, Jong Hyeok Kim, Yong Man Kim, Young Tak Kim, Joo Hyun Nam
OBJECTIVE: The aim of this study was to compare responses to single-agent chemotherapies and evaluate the predictive factors of resistance in low risk (LR) gestational trophoblastic disease (GTD). The chemotherapy agents included methotrexate (MTX) and actinomycin D (ACT-D). METHODS: We conducted a retrospective study of 126 patients with GTD who were treated between 2000 and 2013. A total of 71 patients with LR GTD were treated with MTX (8-day regimen or weekly regimen, n=53) or ACT-D (bi-weekly pulsed regimen or 5-day regimen, n=18)...
October 7, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27716915/stricture-location-predicts-swallowing-outcomes-following-endoscopic-rendezvous-procedures
#3
Katherine N Adams, Rupali N Shah, Robert A Buckmire
OBJECTIVES/HYPOTHESIS: Complete pharyngoesophageal strictures may be encountered by the otolaryngologist as a consequence of radiation/chemoradiotherapy therapies for head and neck cancer. A combined anterograde and retrograde dilation procedure (rendezvous procedure) has proven to be a useful surgical intervention in these cases. We assess the long-term swallowing outcomes of this patient cohort including gastrostomy tube (G-tube) reliance, swallowing quality of life, and variables that contribute to improved swallowing outcomes...
September 26, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27679689/imaging-and-clinical-data-of-placental-site-trophoblastic-tumor-a-case-report
#4
Maryam Niknejadi, Firoozeh Ahmadi, Farnaz Akhbari
Placental site trophoblastic tumor (PSTT) is a very rare variant of gestational trophoblastic tumor. It can occur after normal termination of pregnancy or spontaneous abortion and ectopic or molar pregnancy. There is a wide range of clinical manifestations from a benign condition to an aggressive disease with fatal outcome. One of the most important characteristics of PSTT, unlike other forms of gestational trophoblastic diseases (GTD) is the presence of low beta-subunit of human chorionic gonadotropin (β-hCG) levels because it is a neoplastic proliferation of intermediate trophoblastic cells...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27623148/coordinated-recruitment-of-spir-actin-nucleators-and-myosin-v-motors-to-rab11-vesicle-membranes
#5
Olena Pylypenko, Tobias Welz, Janine Tittel, Martin Kollmar, Florian Chardon, Gilles Malherbe, Sabine Weiss, Carina Ida Luise Michel, Annette Samol-Wolf, Andreas Till Grasskamp, Alistair Hume, Bruno Goud, Bruno Baron, Patrick England, Margaret A Titus, Petra Schwille, Thomas Weidemann, Anne Houdusse, Eugen Kerkhoff
There is growing evidence for a coupling of actin assembly and myosin motor activity in cells. However, mechanisms for recruitment of actin nucleators and motors on specific membrane compartments remain unclear. Here we report how Spir actin nucleators and myosin V motors coordinate their specific membrane recruitment. The myosin V globular tail domain (MyoV-GTD) interacts directly with an evolutionarily conserved Spir sequence motif. We determined crystal structures of MyoVa-GTD bound either to the Spir-2 motif or to Rab11 and show that a Spir-2:MyoVa:Rab11 complex can form...
2016: ELife
https://www.readbyqxmd.com/read/27553923/dynamic-forecasting-conditional-probability-of-bombing-attacks-based-on-time-series-and-intervention-analysis
#6
Shuying Li, Jun Zhuang, Shifei Shen
In recent years, various types of terrorist attacks occurred, causing worldwide catastrophes. According to the Global Terrorism Database (GTD), among all attack tactics, bombing attacks happened most frequently, followed by armed assaults. In this article, a model for analyzing and forecasting the conditional probability of bombing attacks (CPBAs) based on time-series methods is developed. In addition, intervention analysis is used to analyze the sudden increase in the time-series process. The results show that the CPBA increased dramatically at the end of 2011...
August 23, 2016: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/27499598/complete-molar-pregnancy-in-postmenopausal-women
#7
Jasmina Begum, Pallavee Palai, Seetesh Ghose
Gestational trophoblastic disease (GTD) is an abnormal proliferation of trophoblastic tissue during pregnancy. It is a disease of reproductive age, and a few cases have also been seen in women with advanced age, although it is extremely rare in postmenopausal women. Here, we describe an uncommon case of complete hydatidiform mole (CHM) in a postmenopausal woman, who has presented to us with complaints of bleeding per vagina, vomiting with 22 weeks size gravid uterus. Ultrasound finding along with raised serum beta-human chorionic gonadotropin (β-HCG) 400,000 mIU/ml suggested the diagnosis of CHM...
April 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/27489373/get-the-diagnosis-an-evidence-based-medicine-collaborative-wiki-for-diagnostic-test-accuracy
#8
Mark M Hammer, Gavriel D Kohlberg
BACKGROUND: Despite widespread calls for its use, there are challenges to the implementation of evidence-based medicine (EBM) in clinical practice. METHODS: In response to the challenges of finding timely, pertinent information on diagnostic test accuracy, we developed an online, crowd-sourced Wiki on diagnostic test accuracy called Get the Diagnosis (GTD, http://www.getthediagnosis.org). RESULTS: Since its launch in November 2008 till October 2015, GTD has accumulated information on 300 diagnoses, with 1617 total diagnostic entries...
August 3, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27453586/twin-pregnancy-with-one-fetus-and-one-complete-mole-a-case-report
#9
A Freis, M Elsässer, C Sohn, H Fluhr
Twin pregnancy consisting of one fetus and one complete mole (CMCF, complete hydatidiform mole and a coexistent fetus) is an obstetric rarity with an incidence of 1/22 000 to 1/100 000 pregnancies. Associated risks include prematurity, intrauterine death, vaginal bleeding, preeclampsia, hyperthyroidism, theca lutein cysts, uterine rupture and the development of malignant neoplasia in the form of a trophoblastic tumour (GTD, persistent gestational trophoblastic disease), which is thought to be the most common complication...
July 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27424363/centralized-coordination-of-decentralized-assistance-for-patients-with-gestational-trophoblastic-disease-in-brazil-a-viable-strategy-for-developing-countries
#10
Antonio Braga, Marcelo Burlá, Fernanda Freitas, Elza Uberti, Mauricio Viggiano, Sue Yazaki Sun, Izildinha Maestá, Kevin M Elias, Ross S Berkowitz
OBJECTIVE: To report on the Brazilian Association of Gestational Trophoblastic Disease's (GTD) formation of a network of regional care at specialized centers for women with GTD. STUDY DESIGN: We developed a questionnaire composed of 15 questions, which was sent by email to the 38 Brazilian GTD Reference Center (BGTDRC) Directors who are members of the Brazilian Association of GTD, in order to characterize the professionals involved in the care of patients with GTD and the type of assistance provided...
May 2016: Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/27355000/incidence-and-contributing-factors-to-termination-of-the-patient-physician-relationship
#11
Joseph T Santoso, Edmundo Yibirin, Mary Crigger, Jim Wan, Adam C ElNaggar
PURPOSE: Identify the incidence and factors contributing to the termination of gynecologic patient-physician relationships. METHODS: All patients terminated from the practice between January 2008 and December 2012 were identified. Charts were reviewed for demographic information, termination reason, and cancer diagnosis. RESULTS: In the five year study period, 8851 new patients presented to the division of gynecologic oncology. Within this cohort, 123 patient-physician relationships were terminated...
August 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27352577/spontaneous-renal-hemorrhage-caused-by-invasive-mole-a-case-report
#12
S Xiao, Q Mu, Y Wan, M Xue
CASE: The authors report a case with spontaneous renal hemorrhage caused by invasive mole. The diagnosis was gestational trophoblastic disease (GTD), with metastasis to brain, kidneys, and lungs at Stage IV. The patient was given etoposide-methotrexate-actinomycin D plus cyclophosphamide-vincristine (EMACO) treatment regimen for 11 times including three times with consolidation chemotherapies. Laparoscopically-assisted vaginal hysterectomy (LAVH) + laparoscopic-assisted left renal excision + evacuation of the left perirenal hematoma were performed during the eighth chemotherapy...
2016: European Journal of Gynaecological Oncology
https://www.readbyqxmd.com/read/27303685/clostridium-sordellii-lethal-toxin-autoprocessing-and-membrane-localization-activities-drive-gtpase-glucosylation-profiles-in-endothelial-cells
#13
Ryan Craven, D Borden Lacy
Clostridium sordellii infections cause gangrene and edema in humans and gastrointestinal infections in livestock. One of the principle virulence factors is TcsL, a large protein toxin which glucosylates host GTPases to cause cytopathic and cytotoxic effects. TcsL has two enzymatic domains, an N-terminal glucosyltransferase domain (GTD) and an autoprocessing domain responsible for release of the GTD within the cell. The GTD can then use its N-terminal membrane localization domain (MLD) for orientation on membranes and modification of GTPases...
January 2016: MSphere
https://www.readbyqxmd.com/read/27266212/a-10-year-clinical-experience-of-gestational-trophoblastic-disease-at-rajavithi-hospital-2001-2010
#14
Marut Yanaranop, Chalermrat Potikul, Suphet Tuipae
BACKGROUND: Gestational trophoblastic disease (GTD) develops from abnormal cellular proliferation of trophoblasts following fertilization and is categorized as either an hydatidiform mole (HM) or a gestational trophoblastic neoplasia (GTN). OBJECTIVE: To analyze the clinical characteristics, incidence and treatment outcomes of GTD at Rajavithi Hospital. MATERIAL AND METHOD: Medical records of women diagnosed with GTD at Rajavithi Hospital from January 1, 2001 to December 31, 2010 were retrospectively reviewed...
February 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27258726/gestational-trophoblastic-disease-opportunities-for-a-national-registry-collaboration
#15
Alexandre Rozenholc, Jason Dodge, Magali Bréguet, Philippe Sauthier
OBJECTIVE: In rare entities such as gestational trophoblastic disease (GTD), only multi-institutional registries can gather significant number of patients to build up valuable clinical databases. No Canada-wide GTD registry currently exists. We conducted a survey among members of the Canadian Society of Gynecologic Oncology (GOC) to investigate their interest in a pan-Canadian GTD registry. We also took the opportunity to explore their management of GTD. METHODS: An electronic survey was conducted...
July 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27183899/the-effect-of-molar-pregnancies-on-platelet-parameters
#16
Oya Soylu Karapınar, Dilek Benk Şilfeler, Kenan Dolapçıoğlu, Raziye Keskin Kurt, Ahmet Beyazıt
The aim of this study was to compare platelet parameters between abortus groups with gestational trophoblastic disease (GTD) (molar pregnancy, invasive mole, choriocarcinoma, etc) and without disease according to pathological result. The study population consisted of patients with GTD (n = 53) and aborted patients without disease as a control group (n = 53) who were seen in our clinic between January 2010 and December 2013. In this retrospective study, age, gravidity, levels of haemoglobin, white blood cell count, platelets, platelet parameters (mean platelet volume (MPV), platelet distrubition width (PDW), platelet crit (PCT), which shows platelet functions were recorded...
May 16, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27168005/placental-site-trophoblastic-tumor-a-review-of-108-cases-and-their-implications-for-prognosis-and-treatment
#17
J Zhao, W G Lv, F Z Feng, X R Wan, J H Liu, X F Yi, P P Qu, F X Xue, Y M Wu, X Zhao, T Ren, J J Yang, X Xie, Y Xiang
OBJECTIVE: To identify important prognostic factors and optimized treatment strategies through the analysis of the clinical and pathological characteristics of placental site trophoblastic tumor. METHODS: 108 patients with PSTT registered in two GTD centers or in six tertiary hospitals in China were analyzed retrospectively between the years 1998 and 2013. The computerized database of clinical and pathological reports was reviewed on this patient group. The data were subsequently analyzed retrospectively using SPSS software...
July 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27129208/the-globular-tail-domain-of-myosin-5a-functions-as-a-dimer-in-regulating-the-motor-activity
#18
Wen-Bo Zhang, Lin-Lin Yao, Xiang-Dong Li
Myosin-5a contains two heavy chains, which are dimerized via the coiled-coil regions. Thus, myosin-5a comprises two heads and two globular tail domains (GTDs). The GTD is the inhibitory domain that binds to the head and inhibits its motor function. Although the two-headed structure is essential for the processive movement of myosin-5a along actin filaments, little is known about the role of GTD dimerization. Here, we investigated the effect of GTD dimerization on its inhibitory activity. We found that the potent inhibitory activity of the GTD is dependent on its dimerization by the preceding coiled-coil regions, indicating synergistic interactions between the two GTDs and the two heads of myosin-5a...
June 24, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27057813/conservative-chemotherapy-in-gestational-trophoblastic-disease-experience-with-etoposide-methotrexate-and-dactinomycin-chemotherapy
#19
Seung Won Byun, Tae Chul Park, Seog Nyeon Bae
OBJECTIVE: The goal of this study was to evaluate the efficacy, toxicity, and survival of patients in our institution treated by EMA (etoposide, methotrexate [MTX], and dactinomycin) chemotherapy for 3 groups of patients: ones that had low-risk gestational trophoblastic disease (GTD) that was resistant to MTX (group A), those with high-risk GTD (group B), and the group having low-risk GTD but the cancer being metastatic (group C). METHODS: The medical records of 58 patients who received EMA chemotherapy in groups A, B, and C in the 2000 to 2012 period at St Mary's Hospital were examined...
May 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27020699/intraplacental-choriocarcinoma-systematic-review-and-management-guidance
#20
REVIEW
L Jiao, E Ghorani, N J Sebire, M J Seckl
BACKGROUND: Intraplacental choriocarcinoma (IC) is a rare form of malignant gestational trophoblastic disease (GTD). We present a review of 62 cases, including four previously unreported, and a suggested management algorithm. PATIENTS AND METHODS: IC cases and clinical data were identified within the Charing Cross Hospital (CXH) national GTD database (1986-2014) and by systematic literature search (1949-2014). RESULTS: 62 cases were identified including eight from CXH representing 0...
June 2016: Gynecologic Oncology
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