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https://www.readbyqxmd.com/read/29142745/determinants-of-prenatal-anemia-in-ethiopia
#1
Abera Abay, Haile Woldie Yalew, Amare Tariku, Ejigu Gebeye
Background: Anemia is responsible for 20% of maternal mortality worldwide, and it is associated with premature birth, low birth weight, and infant mortality. In Ethiopia, about 22% of pregnant women are anemic. However, literatures are limited, therefore, this study aimed to investigate the prevalence and associated factors of anemia among pregnant women attending antenatal care (ANC) in Asossa Zone Public Health Institutions, northwest Ethiopia. Methods: A facility based cross-sectional study was conducted from February to March 2016...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29137064/clinical-features-and-prognostic-factors-in-patients-with-intraventricular-hemorrhage-caused-by-ruptured-arteriovenous-malformations
#2
Zengpanpan Ye, Xiaolin Ai, Xin Hu, Fang Fang, Chao You
Intraventricular hemorrhage (IVH) was associated with poor outcomes in patients with intracerebral hemorrhage. IVH had a high incidence in patients with ruptured arteriovenous malformations (AVMs). In this study, we aimed to discuss the clinical features and prognostic factors of outcomes in the patients with AVM-related IVH.From January 2010 to January 2016, we collected the data of the patients with AVM-related IVH retrospectively. The data, including clinical and radiological parameters, were collected to evaluate the clinical features...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135346/cerebral-artery-myogenic-reactivity-the-next-frontier-in-developing-effective-interventions-for-subarachnoid-hemorrhage
#3
Darcy Lidington, Jeffrey T Kroetsch, Steffen-Sebastian Bolz
Aneurysmal subarachnoid hemorrhage (SAH) is a devastating cerebral event that kills or debilitates the majority of those afflicted. The blood that spills into the subarachnoid space stimulates profound cerebral artery vasoconstriction and consequently, cerebral ischemia. Thus, once the initial bleeding in SAH is appropriately managed, the clinical focus shifts to maintaining/improving cerebral perfusion. However, current therapeutic interventions largely fail to improve clinical outcome, because they do not effectively restore normal cerebral artery function...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29133539/validation-of-the-ottawa-subarachnoid-hemorrhage-rule-in-patients-with-acute-headache
#4
Jeffrey J Perry, Marco L A Sivilotti, Jane Sutherland, Corinne M Hohl, Marcel Émond, Lisa A Calder, Christian Vaillancourt, Venkatesh Thirganasambandamoorthy, Howard Lesiuk, George A Wells, Ian G Stiell
BACKGROUND: We previously derived the Ottawa Subarachnoid Hemorrhage Rule to identify subarachnoid hemorrhage (SAH) in patients with acute headache. Our objective was to validate the rule in a new cohort of consecutive patients who visited an emergency department. METHODS: We conducted a multicentre prospective cohort study at 6 university-affiliated tertiary-care hospital emergency departments in Canada from January 2010 to January 2014. We included alert, neurologically intact adult patients with a headache peaking within 1 hour of onset...
November 13, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29133197/inhibition-of-leukotriene-b4-synthesis-protects-against-early-brain-injury-possibly-via-reducing-the-neutrophil-generated-inflammatory-response-and-oxidative-stress-after-subarachnoid-hemorrhage-in-rats
#5
Zhen-Nan Ye, Ling-Yun Wu, Jing-Peng Liu, Qiang Chen, Xiang-Sheng Zhang, Yue Lu, Meng-Liang Zhou, Wei Li, Zi-Huan Zhang, Da-Yong Xia, Zong Zhuang, Chun-Hua Hang
Leukotriene B4 (LTB4) is a highly potent neutrophil chemoattractant and neutrophils induces inflammatory response and oxidative stress when they recruit to and infiltrate in the injuried/inflamed site, such as the brain parenchyma after aneurysmal subarachnoid hemorrhage (SAH). This study is to investigate the potential effects of inhibition of LTB4 synthesis on neutrophil recruitment, inflammatory response and oxidative stress, as well as early brain injury (EBI) in rats after SAH. A pre-chiasmatic cistern SAH model of rats was used in this experiment...
November 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29131823/prevalence-of-extracranial-carotid-artery-aneurysms-in-patients-with-an-intracranial-aneurysm
#6
V E C Pourier, C J H C M van Laarhoven, M D I Vergouwen, G J E Rinkel, Gert J de Borst
BACKGROUND AND PURPOSE: Aneurysms in various arterial beds have common risk- and genetic factors. Data on the correlation of extracranial carotid artery aneurysms (ECAA) with aneurysms in other vascular territories are lacking. We aimed to investigate the prevalence of ECAA in patients with an intracranial aneurysm (IA). METHODS: We used prospectively collected databases of consecutive patients registered at the University Medical Center Utrecht with an unruptured intracranial aneurysm (UIA) or aneurysmal Subarachnoid hemorrhage (SAH)...
2017: PloS One
https://www.readbyqxmd.com/read/29129471/higher-intake-of-fish-and-fat-is-associated-with-lower-plasma-s-adenosylhomocysteine-a-cross-sectional-study
#7
Mads V Lind, Lotte Lauritzen, Oluf Pedersen, Henrik Vestergaard, Ken D Stark, Torben Hansen, Alastair B Ross, Mette Kristensen
Several B-vitamins act as co-factors in one-carbon metabolism, a pathway that plays a central role in several chronic diseases. However, there is a lack of knowledge of how diet affects markers in one-carbon metabolism. The aim of this study was to explore dietary patterns and components associated with one-carbon metabolites. We hypothesized that intake of whole-grains and fish would be associated with lower Hcy, and higher SAM:SAH ratio due to their nutrient content. We assessed dietary information using a four-day dietary record in 118 men and women with features of the metabolic syndrome...
October 2, 2017: Nutrition Research
https://www.readbyqxmd.com/read/29127573/eosinophilic-granulomatosis-with-polyangiitis-complicated-by-subarachnoid-hemorrhage-and-coronary-vasculitis-a-case-report-and-review-of-the-literature
#8
REVIEW
Shogo Matsuda, Shuzo Yoshida, Youhei Fujiki, Hidetoshi Satomi, Tohru Takeuchi, Yoshinobu Hirose, Shigeki Makino, Shigeki Arawaka
Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by necrotizing vasculitis of small-sized vessels with extravascular granulomas and eosinophilic infiltration. The case of a 48-year-old Japanese woman with EGPA, who presented concurrently with subarachnoid hemorrhage (SAH) and coronary vasculitis, is reported. She initially presented with bronchial asthma, and then 8 months later she developed various symptoms caused by systemic eosinophilic vasculitis and was admitted to our hospital. Three days after admission, she started oral corticosteroid therapy, and her 2009 Five-Factor Score (FFS) was 0...
November 10, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29127188/epigenetically-mediated-inhibition-of-s-adenosylhomocysteine-hydrolase-and-the-associated-dysregulation-of-1-carbon-metabolism-in-nonalcoholic-steatohepatitis-and-hepatocellular-carcinoma
#9
Igor P Pogribny, Kostiantyn Dreval, Iryna Kindrat, Stepan Melnyk, Leandro Jimenez, Aline de Conti, Volodymyr Tryndyak, Marta Pogribna, Juliana Festa Ortega, S Jill James, Ivan Rusyn, Frederick A Beland
The substantial rise in the prevalence of nonalcoholic steatohepatitis (NASH), an advanced form of nonalcoholic fatty liver disease, and the strong association between NASH and the development of hepatocellular carcinoma indicate the urgent need for a better understanding of the underlying mechanisms. In the present study, by using the Stelic animal model of NASH and NASH-derived liver carcinogenesis, we investigated the role of the folate-dependent 1-carbon metabolism in the pathogenesis of NASH. We demonstrated that advanced NASH and NASH-related liver carcinogenesis are characterized by a significant dysregulation of 1-carbon homeostasis, with diminished expression of key 1-carbon metabolism genes, especially a marked inhibition of the S-adenosylhomocysteine hydrolase (Ahcy) gene and an increased level of S-adenosyl-l-homocysteine (SAH)...
November 10, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29122905/healthy-donor-faecal-transplant-for-corticosteroid-non-responsive-severe-alcoholic-hepatitis
#10
Cyriac Abby Philips, Nikhil Phadke, Karthik Ganesan, Philip Augustine
Patients with severe alcoholic hepatitis (SAH) have high mortality in the presence of steroid unresponsiveness in the absence of clear treatment recommendations. Liver transplantation is the curative option in such cases but is controversial in the wake of severe infections, post-transplant recidivism and long waiting on deceased donor listing. Animal and human studies have shed light on the beneficial effects of gut microbiota modulation in alcoholic liver disease. We present the first report of faecal microbiota transplantation (FMT) in a steroid non-responder in whom, clinical, biochemical and liver disease severity scores improved post-FMT and demonstrate distinct bacterial population changes pre-FMT and post-FMT...
November 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29120850/aggression-as-an-independent-entity-even-in-psychosis-the-role-of-cortisol
#11
Sourav Das, Soumik Sengupta, Kangkan Pathak, Divyashree Sah, Sumit Mehta, Priya Ranjan Avinash, Aparajeeta Baruah, Sailendra Kumar Deuri, Anil Sarmah, Vijay Gogoi, Kamal Narayan Kalita, Jyoti Hazarika
Aggression is a common entity in psychiatric disorders, particularly psychotic disorders. Glucocorticoid hypofunction has been linked to abnormal forms of aggressive behavior in various studies in a 'possibly causal' role. We hypothesise that aggression, even among those having psychosis is associated with glucocorticoid alterations similar to those who are aggressive but not psychotic. To our knowledge, this is the first study attempting to look at the cortisol functioning in relation to both aggression and psychosis...
November 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29119370/vasoconstriction-and-impairment-of-neurovascular-coupling-after-subarachnoid-hemorrhage-a-descriptive-analysis-of-retinal-changes
#12
Catharina Conzen, Walid Albanna, Miriam Weiss, David Kürten, Walthard Vilser, Konstantin Kotliar, Charlotte Zäske, Hans Clusmann, Gerrit Alexander Schubert
Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5-14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C)...
November 8, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29118886/polymorphic-ventricular-tachycardia-secondary-to-subarachnoid-haemorrhage-a-rare-occurrence-in-the-setting-of-normal-qtc
#13
Siddharth Paresh Shah, Priyanka Pitroda, Kinner Patel, Rahul Chandak, Timothy Ford
Subarachnoid hemorrhage (SAH) is a neurologic emergency associated with high mortality rate. Polymorphic ventricular tachycardia (VT) is a rare arrhythmia. It can occur in any setting of a long QT interval and bradycardia. This may result from a cardiomyopathy (both ischemic and non-ischemic), acute coronary ischemia, congenital long QT syndrome, electrolyte disturbances and cerebrovascular diseases. We report a rare case of polymorphic VT of unclear etiology with a normal corrected QT, likely secondary to SAH...
October 2017: Cardiology Research
https://www.readbyqxmd.com/read/29117862/successful-medical-management-of-acute-mesenteric-ischemia-due-to-superior-mesenteric-and-portal-vein-thrombosis-in-a-27-year-old-man-with-protein-s-deficiency-a-case-report
#14
N P Osti, D N Sah, R S Bhandari
BACKGROUND: Acute mesenteric ischemia poses a diagnostic challenge due to nonspecific clinical clues and lack of awareness owing to its rarity. Ischemia due to mesenteric venous thrombosis has a good prognosis compared to arterial cause and can be managed conservatively with early diagnosis. The portomesenteric venous system is an unusual site of thrombosis in patients with protein S deficiency, and its thrombosis is an uncommon cause of acute mesenteric ischemia. CASE PRESENTATION: We present a case of a 27-year-old Mongolian man who presented with acute abdominal pain increasing in severity, and refractory to repeated attempts at treatment with a misdiagnosis of acute peptic ulcer disease...
November 9, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29117032/a-preliminary-observational-study-of-anovulatory-uterine-bleeding-after-aneurysmal-subarachnoid-hemorrhage
#15
Suzanne M Brown, Susan W Fifield, Michael A Pizzi, David Alejos, Alexa N Richie, Tri A Dinh, William P Cheshire, Shon E Meek, William D Freeman
INTRODUCTION: It was observed that women with aneurysmal subarachnoid hemorrhage (aSAH) tended to have earlier menses than a typical 21- to 28-day cycle. The goal was to determine whether there is an association between aSAH and early onset of menses. METHODS: All cases of aSAH in women aged 18 to 55 years who were admitted to our facility's neuroscience intensive care unit from June 1, 2011, to June 30, 2012, were reviewed. The electronic healthcare record for each of these patients was examined for documentation of menses onset, computed tomography of the head, brain aneurysm characteristics, modified Fisher score and Glasgow Coma Scale on admission, presence/absence of vasospasm, medical/surgical history, and use of medications that affect the menstrual cycle...
December 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29115588/limb-remote-ischemic-post%C3%A2-conditioning-reduces-injury-and-improves-long%C3%A2-term-behavioral-recovery-in-rats-following-subarachnoid-hemorrhage-possible-involvement-of-the-autophagic-process
#16
Xiang Hu, Tao Lv, Shao-Feng Yang, Xiao-Hua Zhang, Yi-Feng Miao
Hemorrhage‑related neurologic injury is a primary cause of disability and mortality following subarachnoid hemorrhage (SAH). The aim of the present study was to investigate the potential neuroprotective effect and the possible role of autophagy in limb remote ischemic post‑conditioning (RIPostC) using an endovascular puncture rat model of SAH. RIPostC was induced by three cycles of occlusion (10 min) and release (10 min) in the bilateral femoral artery using an aneurysm clip. Early RIPostC began immediately following SAH, delayed RIPostC began following a 30 min delay and the repeated RIPostC group underwent the protocol every day for 3 days...
October 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29114365/stroke-subtypes-risk-factors-and-mortality-rate-in-northwest-of-iran
#17
Mehdi Farhoudi, Kaveh Mehrvar, Homayoun Sadeghi-Bazargani, Mazyar Hashemilar, Manouchehr Seyedi-Vafaee, Elyar Sadeghi-Hokmabad, Reza Rikhtegar, Babak Saber-Maroof, Mohammad Abutalebi, Mahsa Rezaei, Sahar Vaferi, Alireza Aghili, Omid Ebrahimi
Background: Stroke is the second most common cause of death and first cause of disability in adults in the world. About 80% of all stroke deaths occur in developing countries. So far, the data on stroke epidemiology have been limited in Iran. Therefore, this study was focused on stroke demographic data, risk factors, types and mortality. Methods: A retrospective study was done in two university tertiary referral hospitals in Tabriz, northwest of Iran, from March 2008 to April 2013. Patients diagnosed with stroke were enrolled in the study...
July 6, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/29109695/the-role-of-thromboinflammation-in-delayed-cerebral-ischemia-after-subarachnoid-hemorrhage
#18
REVIEW
Devin W McBride, Spiros L Blackburn, Kumar T Peeyush, Kanako Matsumura, John H Zhang
Delayed cerebral ischemia (DCI) is a major determinant of patient outcome following aneurysmal subarachnoid hemorrhage. Although the exact mechanisms leading to DCI are not fully known, inflammation, cerebral vasospasm, and microthrombi may all function together to mediate the onset of DCI. Indeed, inflammation is tightly linked with activation of coagulation and microthrombi formation. Thromboinflammation is the intersection at which inflammation and thrombosis regulate one another in a feedforward manner, potentiating the formation of thrombi and pro-inflammatory signaling...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29108808/fatal-intracranial-aneurysms-and-dissections-causing-subarachnoid-hemorrhage-an-epidemiological-and-pathological-analysis-of-607-legal-autopsy-cases
#19
Shinjiro Mori, Shirushi Takahashi, Akira Hayakawa, Kazuyuki Saito, Aya Takada, Tatsushige Fukunaga
BACKGROUND: There are no detailed reports, in terms of epidemiology and pathology, on intracranial aneurysms and on dissections that were found in unexpected fatal subarachnoid hemorrhage (SAH) cases. In this report we analyzed, based on large-sized medicolegal autopsy cases, the detailed epidemiology and pathological aspects of both lesions. METHODS: We analyzed 607 autopsy cases of unexpected fatal SAHs including 496 aneurysms and 111 dissections. RESULTS: The following results were obtained: (1) Patients who died of dissections were younger than those who died of aneurysms; (2) symptom prevalence rates of aneurysms were 31...
November 3, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29107164/subarachnoid-hemorrhage-and-readmissions-national-rates-causes-risk-factors-and-outcomes-in-16-001-hospitalized-patients
#20
Kavelin Rumalla, Kyle A Smith, Paul M Arnold, Manoj K Mittal
INTRODUCTION: The acute complications of aneurysmal subarachnoid hemorrhage (aSAH) often lead to readmissions, which are linked to hospital reimbursement. The national rates, causes, risk factors, and outcomes associated with 30-day and 90-day readmission following aSAH have not previously been reported. METHODS: The Nationwide Readmissions Database was queried from January through September 2013 for all patients (age ≥ 18) with a diagnosis of aSAH. Data points included demographics, comorbidities, complications, and discharge outcomes...
October 26, 2017: World Neurosurgery
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