Tadanori Hamano, Norimichi Shirafuji, Shu-Hui Yen, Hirotaka Yoshida, Nicholas M Kanaan, Kouji Hayashi, Masamichi Ikawa, Osamu Yamamura, Youshi Fujita, Masaru Kuriyama, Yasunari Nakamoto
Neurofibrillary tangles, one of the pathological hallmarks of Alzheimer's disease, consist of highly phosphorylated tau proteins. Tau protein binds to microtubules and is best known for its role in regulating microtubule dynamics. However, if tau protein is phosphorylated by activated major tau kinases, including glycogen synthase kinase 3β or cyclin-dependent kinase 5, or inactivated tau phosphatase, including protein phosphatase 2A, its affinity for microtubules is reduced, and the free tau is believed to aggregate, thereby forming neurofibrillary tangles...
May 2020: Neurobiology of Aging