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https://www.readbyqxmd.com/read/29784559/anodic-versus-cathodic-neurostimulation-of-the-subthalamic-nucleus-a-randomized-controlled-study-of-acute-clinical-effects
#1
Anna Dalal Kirsch, Sharon Hassin-Baer, Cordula Matthies, Jens Volkmann, Frank Steigerwald
INTRODUCTION: Stimulation settings of deep brain stimulation (DBS) have evolved empirically within a limited parameter space dictated by first generation devices. There is a need for controlled clinical studies, which evaluate efficacy and safety of established programming practice against novel programming options provided by modern neurostimulation devices. METHODS: Here, we tested a polarity reversal from conventional monopolar cathodic to anodic stimulation in an acute double-blind, randomized, cross-over study in patients with PD implanted with bilateral STN DBS...
May 16, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29784541/deciphering-synergistic-characteristics-of-redox-mediators-stimulated-echinenone-production-of-gordonia-terrae-twih01
#2
Bin Xu, Bor-Yann Chen, Kuan-Chieh Huang, Qing-Jiang Sun, John Chi-Wei Lan
This first-attempt study tended to decipher synergistic interactions of model redox mediators (RMs) to echinenone production for electrochemically-steered fermentation (ESF). The findings indicated that supplement of RMs could significantly stimulate the production performance of fermentation (e.g., 36% for 4-aminophenol) which was parallel with stimulation of bioelectricity generation in microbial fuel cells (MFCs) as prior studies mentioned. Although redox mediators could usually enhance electron transport extracellular compartment, the mechanisms of bioelectricity generation in MFCs and echinenone production in ESF were very likely functioned in the extracellular and the intracellular compartment, respectively...
May 18, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29782510/individual-differences-in-learning-correlate-with-modulation-of-brain-activity-induced-by-transcranial-direct-current-stimulation
#3
Brian Falcone, Atsushi Wada, Raja Parasuraman, Daniel E Callan
Transcranial direct current stimulation (tDCS) has been shown to enhance cognitive performance on a variety of tasks. It is hypothesized that tDCS enhances performance by affecting task related cortical excitability changes in networks underlying or connected to the site of stimulation facilitating long term potentiation. However, many recent studies have called into question the reliability and efficacy of tDCS to induce modulatory changes in brain activity. In this study, our goal is to investigate the individual differences in tDCS induced modulatory effects on brain activity related to the degree of enhancement in performance, providing insight into this lack of reliability...
2018: PloS One
https://www.readbyqxmd.com/read/29773509/the-role-of-the-inferior-frontal-gyrus-in-vicarious-social-touch-a-transcranial-direct-current-stimulation-tdcs-study
#4
Leehe Peled-Avron, Laura Glasner, Hila Z Gvirts, Simone G Shamay-Tsoory
The neural mechanisms facilitating the experience of vicarious social touch are largely unknown. The right inferior frontal gyrus (rIFG) has been suggested as part of a simulation observation-execution neural network that plays a key role in the perception of tactile stimuli. Considering that vicarious social touch involves vicarious sharing of emotions, we hypothesized that emotional empathy, i.e., the ability to feel what another individual is feeling, modulates the neural responses to vicarious touch. To examine the role of the rIFG in vicarious touch and its modulation by levels of emotional empathy, we used anodal transcranial direct current stimulation (tDCS) on forty participants who observed photos depicting social touch, nonsocial touch or no touch during tDCS or sham stimulation...
April 30, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29763676/effect-of-single-session-dual-tdcs-before-physical-therapy-on-lower-limb-performance-in-sub-acute-stroke-patients-a-randomized-sham-controlled-crossover-study
#5
Wanalee Klomjai, Benchaporn Aneksan, Anuchai Pheungphrarattanatrai, Thanwarat Chantanachai, Nattha Choowong, Soontaree Bunleukhet, Paradee Auervitchayapat, Yongchai Nilanon, Vimonwan Hiengkaew
Anodal stimulation increases cortical excitably, whereas cathodal stimulation decreases cortical excitability. Dual transcranial direct current stimulation (tDCS; anodal over the lesioned hemisphere, cathodal over the non-lesioned hemisphere) was found to enhance motor learning. The corresponding tDCS-induced changes were reported to reduce the inhibition exerted by the unaffected hemisphere on the affected hemisphere and restore the normal balance of the interhemispheric inhibition. Most studies were devoted to the possible modification of upper-limb motor function after tDCS; however, almost no study has demonstrated its effects on lower-limb function and gait, which are also commonly disordered in stroke patients with motor deficits...
May 12, 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29760645/systems-analysis-of-human-visuo-myoelectric-control-facilitated-by-anodal-transcranial-direct-current-stimulation-in-healthy-humans
#6
Vinh Kha, Aguida S Foerster, Susan Bennett, Michael A Nitsche, Filip Stefanovic, Anirban Dutta
Induction of neuroplasticity by transcranial direct current stimulation (tDCS) applied to the primary motor cortex facilitates motor learning of the upper extremities in healthy humans. The impact of tDCS on lower limb functions has not been studied extensively so far. In this study, we applied a system identification approach to investigate the impact of anodal transcranial direct current stimulation of the leg area of the motor cortex via the human visuo-myoelectric controller. The visuo-myoelectric reaching task (VMT) involves ballistic muscle contraction after a visual cue...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29759944/testing-assumptions-on-prefrontal-transcranial-direct-current-stimulation-comparison-of-electrode-montages-using-multimodal-fmri
#7
Jana Wörsching, Frank Padberg, Stephan Goerigk, Irmgard Heinz, Christine Bauer, Christian Plewnia, Alkomiet Hasan, Birgit Ertl-Wagner, Daniel Keeser
BACKGROUND: Transcranial direct current stimulation (tDCS) of the prefrontal cortex (PFC) has been widely applied in cognitive neurosciences and advocated as a therapeutic intervention, e.g. in major depressive disorder. Although several targets and protocols have been suggested, comparative studies of tDCS parameters, particularly electrode montages and their cortical targets, are still lacking. OBJECTIVE: This study investigated a priori hypotheses on specific effects of prefrontal-tDCS montages by using multimodal functional magnetic resonance imaging (fMRI) in healthy participants...
May 4, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29756180/anodal-tdcs-of-the-swallowing-motor-cortex-for-treatment-of-dysphagia-in-multiple-sclerosis-a-pilot-open-label-study
#8
G Cosentino, R Gargano, G Bonura, S Realmuto, E Tocco, P Ragonese, M Gangitano, E Alfonsi, B Fierro, F Brighina, G Salemi
Swallowing difficulties are a common symptom of multiple sclerosis (MS). The early detection and treatment of dysphagia is critical to prevent complications, including poor nutrition, dehydration, and lung infections. Recently, transcranial direct current stimulation (tDCS) has been proven to be effective in ameliorating swallowing problems in stroke patients. In this pilot study, we aimed to assess safety and efficacy of transcranial direct current stimulation (tDCS) in the treatment of dysphagia in MS patients...
May 13, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29754106/the-effect-of-transcranial-direct-current-stimulation-on-psychotic-symptoms-of-schizophrenia-is-associated-with-oxy-hemoglobin-concentrations-in-the-brain-as-measured-by-near-infrared-spectroscopy-a-pilot-study
#9
Zui Narita, Takamasa Noda, Shiori Setoyama, Kazuki Sueyoshi, Takuma Inagawa, Tomiki Sumiyoshi
Transcranial direct current stimulation (tDCS) has been shown to be effective in treating some of the symptoms of schizophrenia. In the current study, we sought to determine whether oxy-hemoglobin ([oxy-Hb]), measured by near-infrared spectroscopy (NIRS), is associated with effects of transcranial direct current stimulation (tDCS) on psychotic symptoms of schizophrenia. Twenty-six patients underwent tDCS (2 mA × 20 min) two times per day for five consecutive days. The anodal electrode was placed over the left dorsolateral prefrontal cortex while the cathodal electrode was placed over the right supraorbital region...
May 8, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29753310/roles-of-the-right-temporo-parietal-and-premotor-cortices-in-self-location-and-body-ownership
#10
Silvia Convento, Daniele Romano, Angelo Maravita, Nadia Bolognini
In the rubber hand illusion (RHI), the feeling that a fake hand belongs to oneself can be induced by the simultaneous, congruent touch of the fake visible hand and one's own hidden hand. This condition is also associated with a recalibration of the perceived location of the real hand. A cortical network, including premotor and temporo-parietal areas, has been proposed as the basis of the RHI. However, the causal contribution of these areas to the discrete illusory components remains unclear. We used transcranial direct current stimulation (tDCS) to assess the contribution of the right premotor cortex (rPMc) and the right temporo-parietal junction (rTPJ) to the RHI and explored the role of these areas in modulating the subjective experience of embodiment and the misperception of the hand position...
May 12, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29750977/high-definition-transcranial-direct-current-stimulation-changes-older-adults-subjective-sleep-and-corresponding-resting-state-functional-connectivity
#11
Jing Sheng, Chao Xie, Dong-Qiong Fan, Xu Lei, Jing Yu
With advanced age, older adults show functional deterioration in sleep. Transcranial direct current stimulation (tDCS), a noninvasive brain stimulation, modulates individuals' behavioral performance in various cognitive domains. However, the modulation effect and neural mechanisms of tDCS on sleep, especially for the elderly population are not clear. Here, we aimed to investigate whether high-definition transcranial direct current stimulation (HD-tDCS) could modulate community-dwelling older adults' subjective sleep and whether these potential improvements are associated with the large-scale brain activity alterations recorded by functional magnetic resonance imaging...
May 8, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29747540/anodal-transcranial-direct-current-stimulation-to-enhance-rehabilitation-in-individuals-with-rotator-cuff-tendinopathy-a-triple-blind-randomized-control-trial
#12
Amélie Fournier Belley, Catherine Mercier, Maude Bastien, Guillaume Léonard, Nathaly Gaudreault, Jean-Sébastien Roy
Study Design Triple-blind parallel-group randomized control trial. Background Anodal transcranial direct current stimulation (a-tDCS) has been shown to enhance the effects of sensorimotor training in neurological populations. For treatment of rotator cuff (RC) tendinopathy, sensorimotor training leads to reduce pain and increase function. Addition of a-tDCS during a rehabilitation program centered on sensorimotor training could improve treatment outcome. Objective To compare a group receiving a rehabilitation program centered on sensorimotor training with a-tDCS to a group receiving the same rehabilitation program with sham a-tDCS in individuals with RC tendinopathy...
May 10, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29740271/a-preliminary-comparison-of-motor-learning-across-different-non-invasive-brain-stimulation-paradigms-shows-no-consistent-modulations
#13
Virginia Lopez-Alonso, Sook-Lei Liew, Miguel Fernández Del Olmo, Binith Cheeran, Marco Sandrini, Mitsunari Abe, Leonardo G Cohen
Non-invasive brain stimulation (NIBS) has been widely explored as a way to safely modulate brain activity and alter human performance for nearly three decades. Research using NIBS has grown exponentially within the last decade with promising results across a variety of clinical and healthy populations. However, recent work has shown high inter-individual variability and a lack of reproducibility of previous results. Here, we conducted a small preliminary study to explore the effects of three of the most commonly used excitatory NIBS paradigms over the primary motor cortex (M1) on motor learning (Sequential Visuomotor Isometric Pinch Force Tracking Task) and secondarily relate changes in motor learning to changes in cortical excitability (MEP amplitude and SICI)...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29736552/comparison-of-two-configurations-of-transcranial-direct-current-stimulation-for-aphasia-treatment
#14
Kerstin Spielmann, W Mieke van de Sandt-Koenderman, Majanka H Heijenbrok-Kal, Gerard M Ribbers
OBJECTIVE: To compare 2 configurations of transcranial direct current stimulation (tDCS) for treatment of aphasia. DESIGN: Randomized cross-over study. SUBJECTS: Patients with chronic post-stroke aphasia (n = 13). METHODS: tDCS was combined with word-finding therapy in 3 single sessions. In session 1, sham-tDCS/pseudo-stimulation was applied. In sessions 2 and 3, 2 active configurations were provided in random order: anodal tDCS over the left inferior frontal gyrus (l-IFG) and anodal tDCS over the left posterior superior temporal gyrus (l-STG)...
May 8, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29736192/the-effects-of-transcranial-direct-current-stimulation-on-the-cognitive-functions-in-older-adults-with-mild-cognitive-impairment-a-pilot-study
#15
Pablo Cruz Gonzalez, Kenneth N K Fong, Ted Brown
Objective: The aim of this pilot study was to investigate whether the use of anodal transcranial direct current stimulation (tDCS) on the left dorsolateral prefrontal cortex could boost the effects of a cognitive stimulation (CS) programme using a tablet on five older adults with mild cognitive impairment (MCI). Method: A single-subject study of A-B-C-A design was used. After the baseline with the administration of CS (phase A), a sham treatment with CS was applied (B)...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/29734347/single-transcranial-direct-current-stimulation-in-schizophrenia-randomized-cross-over-study-of-neurocognition-social-cognition-erps-and-side-effects
#16
Yuri Rassovsky, Walter Dunn, Jonathan K Wynn, Allan D Wu, Marco Iacoboni, Gerhard Hellemann, Michael F Green
Over the last decades, the treatment of schizophrenia has shifted fundamentally from a focus on symptom reduction to a focus on recovery and improving aspects of functioning. In this study, we examined the effect of transcranial direct current stimulation (tDCS) on social cognitive and nonsocial neurocognitive functions, as well as on electroencephalogram (EEG) measures, in individuals with schizophrenia. Thirty-seven individuals with schizophrenia were administered one of three different tDCS conditions (cathodal, anodal, and sham) per visit over the course of three visits, with approximately one week between each visit...
2018: PloS One
https://www.readbyqxmd.com/read/29727626/effects-of-prefrontal-tdcs-on-executive-function-methodological-considerations-revealed-by-meta-analysis
#17
Michael J Imburgio, Joseph M Orr
A meta-analysis of studies using single-session transcranial direct current stimulation (tDCS) to target the dorsolateral prefrontal cortex (DLPFC) was undertaken to examine the effect of stimulation on executive function (EF) in healthy samples. 27 studies were included in analyses, yielding 71 effect sizes. The most relevant measure for each task was determined a priori and used to calculate Hedge's g. Methodological characteristics of each study were examined individually as potential moderators of effect size...
May 1, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29726731/dose-response-of-somatosensory-cortex-repeated-anodal-transcranial-direct-current-stimulation-on-vibrotactile-detection-a-randomized-sham-controlled-trial
#18
Brookes Folmli, Bulent Turman, Peter Johnson, Allan Abbott
This randomized sham-controlled trial investigated anodal transcranial direct current stimulation (tDCS) over the somatosensory cortex contralateral to hand dominance for dose-response (1mA-20 minutes x 5 days) effects on vibrotactile detection thresholds (VDT). VDT was measured before and after tDCS on days 1,3&5 for low (30hz) and high (200hz) frequency vibrations on the dominant and non-dominant hands in 29 healthy adults (mean age = 22.86; 15 males, 14 females). Only the dominant hand 200Hz VDT displayed statistically significant medium effect size improvement for mixed model analysis of variance time x group interaction for active tDCS compared to sham...
May 4, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29725315/tdcs-stimulation-of-the-dlpfc-selectively-moderates-the-detrimental-impact-of-emotion-on-analytical-reasoning
#19
Bastien Trémolière, Véronique Maheux-Caron, Jean-François Lepage, Isabelle Blanchette
There is evidence of a detrimental effect of emotion on reasoning. Recent studies suggest that this relationship is mediated by working memory, a function closely associated with the dorsolateral prefrontal cortex (dlPFC). Relying on transcranial direct current stimulation (tDCS), the present research explores the possibility that anodal stimulation of the dlPFC has the potential to prevent the effect of emotion on analytical reasoning. Thirty-four participants took part in a lab experiment and were tested twice: one session using offline anodal stimulation (with a 2 mA current stimulation applied to the left dlPFC for 20 min), one session using a control (sham) stimulation...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29725288/no-change-in-social-decision-making-following-transcranial-direct-current-stimulation-of-the-right-temporoparietal-junction
#20
Laura F Blair-West, Kate E Hoy, Phillip J Hall, Paul B Fitzgerald, Bernadette M Fitzgibbon
The right temporoparietal junction (rTPJ) is thought to play an important role in social cognition and pro-social decision-making. One way to explore this link is through the use of transcranial direct current stimulation (tDCS), a non-invasive brain stimulation method that is able to modulate cortical activity. The aim of this research was therefore to determine whether anodal tDCS to the rTPJ altered response to a social decision-making task. In this study, 34 healthy volunteers participated in a single-center, double-blinded, sham-controlled crossover design...
2018: Frontiers in Neuroscience
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