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"ssti" OR "skin and soft tissue infection" OR "cutaneous abscess" OR "skin abscess"

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https://www.readbyqxmd.com/read/27917738/incidence-and-factors-associated-with-emergency-department-visits-for-recurrent-skin-and-soft-tissue-infections-in-patients-in-california-2005-2011
#1
L May, E Y Klein, E M Martinez, N Mojica, L G Miller
More than 2 million visits for skin and soft tissue infections (SSTIs) are seen in US emergency departments (EDs) yearly. Up to 50% of patients with SSTIs, suffer from recurrences, but associated factors remain poorly understood. We performed a retrospective study of patients with primary diagnosis of SSTI between 2005 and 2011 using California ED discharge data from the State Emergency Department Databases and State Inpatient Databases. Using a multivariable logistic regression, we examined factors associated with a repeat SSTI ED visits up to 6 months after the initial SSTI...
December 5, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27917724/periumbilical-skin-and-soft-tissue-infections-resulting-from-a-newborn-tracking-device
#2
Kenneth M Zangwill, Alma D Belis, Kimberly J Ko, Janet M Landholm
No abstract text is available yet for this article.
December 5, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27907197/clinical-experience-of-patients-receiving-doripenem-containing-regimens-for-the-treatment-of-healthcare-associated-infections
#3
Chien-Ming Chao, Chi-Chung Chen, Hui-Ling Huang, Yin-Ching Chuang, Chih-Cheng Lai, Hung-Jen Tang
In this study, we retrospectively reviewed the clinical experience of patients receiving doripenem-containing regimens for the treatment of healthcare-associated infections (HCAIs) in a tertiary care center and assessed the clinical usefulness of doripenem therapy in this clinical setting. In this retrospective study, the medical records of all adult patients who had ever received doripenem-containing therapy for the treatment of HCAIs were reviewed between September 1, 2012 and August 31, 2014, and the following data were extracted: age, gender, type of infection, disease severity, underlying comorbidities or conditions, and laboratory results...
2016: PloS One
https://www.readbyqxmd.com/read/27902667/managing-skin-and-soft-tissue-infections-in-the-emergency-department-observation-unit
#4
Shabana Yusuf, Joseph L Hagan, Aderonke O Adenkule-Ojo
BACKGROUND: Skin and soft tissue infections (SSTIs) are a common reason for presentation to the emergency department (ED) and account for 3% of ED visits. Patients with a diagnosis of cellulitis requiring intravenous (IV) antibiotics have traditionally been admitted to the hospital. In our institution, these patients are placed in the ED Observation Unit (EDOU) for IV antibiotics. OBJECTIVES: The purpose of this study is to determine if 3 doses of IV antibiotics are adequate to document clinical improvement in children with uncomplicated SSTI...
November 29, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27899072/appropriateness-of-antibiotic-management-of-uncomplicated-skin-and-soft-tissue-infections-in-hospitalized-adult-patients
#5
Thomas L Walsh, Lynn Chan, Chelsea I Konopka, Michael J Burkitt, Matthew A Moffa, Derek N Bremmer, Monika A Murillo, Courtney Watson, Noreen H Chan-Tompkins
BACKGROUND: Skin and soft tissue infections (SSTIs) are a leading cause for hospitalizations in the United States. Few studies have addressed the appropriateness of antibiotic therapy in the management of SSTIs without complicating factors. We aimed to determine the appropriateness of antibiotic treatment duration for hospitalized adult patients with uncomplicated SSTIs. METHODS: This was a retrospective analysis performed at two academic medical centers in Pittsburgh, Pennsylvania on patients aged 18 years and older with primary ICD-9 code for SSTIs admitted August 1st, 2014-March 31st, 2015...
November 29, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27897966/behavioral-characteristics-and-injection-practices-associated-with-skin-and-soft-tissue-infections-among-people-who-inject-drugs-a-community-based-observational-study
#6
Disa Dahlman, Anders Håkansson, Alex H Kral, Lynn Wenger, Elizabeth K Ball, Scott P Novak
BACKGROUND: People who inject drugs (PWID) are at increased risk for bacterial skin and soft tissue infections (SSTIs). While SSTIs pose significant health risks, little is known about their prevalence and characteristics in the population of PWID in the United States. This study investigates whether behavioral factors related to skin and equipment hygiene and tissue-damaging injection practices are associated with recent SSTIs among PWID. METHODS: Active PWID were recruited using targeted sampling in San Francisco in 2011-2013...
November 29, 2016: Substance Abuse
https://www.readbyqxmd.com/read/27895134/vancomycin-and-the-risk-of-aki-a-systematic-review-and-meta-analysis
#7
Abhisekh Sinha Ray, Ammar Haikal, Kassem A Hammoud, Alan S L Yu
BACKGROUND AND OBJECTIVES: Vancomycin has been in use for more than half a century, but whether it is truly nephrotoxic and to what extent are still highly controversial. The objective of this study was to determine the risk of AKI attributable to intravenous vancomycin. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a systematic review of randomized, controlled trials and cohort studies that compared patients treated with intravenous vancomycin with a control group of patients given a comparator nonglycopeptide antibiotic and in which kidney function or kidney injury outcomes were reported...
November 28, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27894236/virulence-factor-targeting-of-the-bacterial-pathogen-staphylococcus-aureus-for-vaccine-and-therapeutics
#8
Trevor Kane, Katelyn Carothers, Shaun Lee
Staphylococcus aureus is a major bacterial pathogen capable of causing a range of infections in humans from gastrointestinal disease, skin and soft tissue infections, to severe outcomes such as sepsis. Staphylococcal infections in humans can be frequent and recurring, with treatments becoming less effective due to the growing persistence of antibiotic resistant S. aureus strains. Significant research into virulence factors produced by S. aureus have yielded many important findings regarding specific mechanisms that contribute to its overall pathogenesis...
November 28, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27891222/epidemiology-of-klebsiella-pneumoniae-bloodstream-infections-in-a-teaching-hospital-factors-related-to-the-carbapenem-resistance-and-patient-mortality
#9
Lijun Tian, Ruoming Tan, Yang Chen, Jingyong Sun, Jialin Liu, Hongping Qu, Xiaoli Wang
BACKGROUND: Although Klebsiella pneumoniae bloodstream infections (KP-BSIs) have recently attracted attention due to an alarming raise in morbidity and mortality, there have been few reports on the epidemiology of KP-BSIs in mainland China. We sought to describe the epidemiological, microbiological, and clinical characteristics of KP-BSIs, focusing on the risk factors of carbapenem resistance and patient mortality. METHODS: A retrospective analysis of WHONET data of KP-BSI patients admitted to a teaching hospital in Shanghai, China, between January 1, 2011 and December 31, 2015 was performed, and the annual percentage of patients with carbapenem-resistant K...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27891094/anti-acne-activity-of-italian-medicinal-plants-used-for-skin-infection
#10
Kate Nelson, James T Lyles, Tracy Li, Alessandro Saitta, Eugenia Addie-Noye, Paula Tyler, Cassandra L Quave
Propionibacterium acnes is implicated in the pathogenesis of acne vulgaris, which impacts >85% of teenagers. Novel therapies are in high demand and an ethnopharmacological approach to discovering new plant sources of anti-acne therapeutics could contribute to filling this void in effective therapies. The aims of our study were two-fold: (1) To determine if species identified in ethnopharmacological field studies as having traditional uses for skin and soft tissue infection (SSTI) exhibit significantly more activity against P...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27887585/reduction-in-antibiotic-prescribing-for-respiratory-tract-infections-in-swedish-primary-care-a-retrospective-study-of-electronic-patient-records
#11
Mia Tyrstrup, Anders Beckman, Sigvard Mölstad, Sven Engström, Christina Lannering, Eva Melander, Katarina Hedin
BACKGROUND: Swedish studies on antibiotic use in primary care have been based on one-week registrations of infections. In order to study adherence to guidelines, analyses based on large databases that provide information on diagnosis linked prescriptions, are needed. This study describes trends in management of infections in Swedish primary care particularly with regards to antibiotic prescribing and adherence to national guidelines. METHODS: A descriptive study of Sweden's largest database regarding diagnosis linked antibiotic prescription data, the Primary care Record of Infections in Sweden (PRIS), for the years 2008, 2010 and 2013...
November 25, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27876477/current-prescribing-practices-for-skin-and-soft-tissue-infections-in-nursing-homes
#12
Diana Feldstein, Philip D Sloane, David Weber, Kimberly Ward, David Reed, Sheryl Zimmerman
OBJECTIVES: Antibiotic stewardship has been called for across all sites of health care, including nursing homes (NHs). Skin and soft tissue infections (SSTIs) are the third most common indication for antibiotics in the NH, and so should be a focus of stewardship. This study audited medical records to identify signs and symptoms of SSTIs treated with antibiotics in relation to the McGeer criteria for surveillance, the Loeb minimum criteria for antibiotic initiation, and prescribing recommendations of the Infectious Disease Society of America...
November 18, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27876059/a-prospective-observational-cohort-study-in-primary-care-practices-to-identify-factors-associated-with-treatment-failure-in-staphylococcus-aureus-skin-and-soft-tissue-infections
#13
Grace C Lee, Ronald G Hall, Natalie K Boyd, Steven D Dallas, Liem C Du, Lucina B Treviño, Sylvia B Treviño, Chad Retzloff, Kenneth A Lawson, James Wilson, Randall J Olsen, Yufeng Wang, Christopher R Frei
BACKGROUND: The incidence of outpatient visits for skin and soft tissue infections (SSTIs) has substantially increased over the last decade. The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has made the management of S. aureus SSTIs complex and challenging. The objective of this study was to identify risk factors contributing to treatment failures associated with community-associated S. aureus skin and soft tissue infections SSTIs. METHODS: This was a prospective, observational study among 14 primary care clinics within the South Texas Ambulatory Research Network...
November 22, 2016: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/27864622/how-obesity-impacts-outcomes-of-infectious-diseases
#14
A Atamna, A Elis, E Gilady, L Gitter-Azulay, J Bishara
Obesity is associated with co-morbidities and increased risk of acquiring infections with worse outcomes. Paradoxically, a few studies indicate that obesity may have a decreased mortality in hospitalized patients with pneumonia. The objective of this study was to determine the impact of body mass index (BMI) on short-term all-cause mortality and clinical outcomes among hospitalized adults with pneumonia, urinary tract infections, skin and soft tissue infections, and bacteremia. The study cohort included 1437 consecutive patients who were admitted with infectious disease including pneumonia (717), urinary tract infection (506), bacteremia (69), and skin and soft tissue infections (145), and hospitalized in internal medical departments, during 2013-2015...
November 18, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27864392/bet-1-trimethoprim-sulfamethoxazole-in-uncomplicated-skin-abscess
#15
Reece Baker, Jason Seamon
A short cut review was carried out to establish whether incision and drainage followed by treatment with oral trimethoprim-sulfamethoxazole is better than incision and drainage alone at treating patients with uncomplicated skin abscesses. One hundred and ninety-seven papers were found using the reported searches, of which three presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated...
December 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27855652/performance-of-an-electronic-health-record-based-phenotype-algorithm-to-identify-community-associated-methicillin-resistant-staphylococcus-aureus-cases-and-controls-for-genetic-association-studies
#16
Kathryn L Jackson, Michael Mbagwu, Jennifer A Pacheco, Abigail S Baldridge, Daniel J Viox, James G Linneman, Sanjay K Shukla, Peggy L Peissig, Kenneth M Borthwick, David A Carrell, Suzette J Bielinski, Jacqueline C Kirby, Joshua C Denny, Frank D Mentch, Lyam M Vazquez, Laura J Rasmussen-Torvik, Abel N Kho
BACKGROUND: Community associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is one of the most common causes of skin and soft tissue infections in the United States, and a variety of genetic host factors are suspected to be risk factors for recurrent infection. Based on the CDC definition, we have developed and validated an electronic health record (EHR) based CA-MRSA phenotype algorithm utilizing both structured and unstructured data. METHODS: The algorithm was validated at three eMERGE consortium sites, and positive predictive value, negative predictive value and sensitivity, were calculated...
November 17, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27852674/focus-on-mrsa-sa-ssti%C3%A2-assay-failure-in-prosthetic-joint-infections-213-consecutive-patients-later
#17
Marie Titécat, Frédéric Wallet, Olivier Robineau, Michel Valette, Henri Migaud, Eric Senneville, Caroline Loïez
In prosthetic joint infection (PJI) cases (1), rapid detection of methicillin-resistant staphylococci (MRS) is the key to avoid the use of broad-spectrum antimicrobials such as vancomycin.….
November 16, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27851746/livestock-associated-antibiotic-resistant-staphylococcus-aureus-nasal-carriage-and-recent-skin-and-soft-tissue-infection-among-industrial-hog-operation-workers
#18
Maya Nadimpalli, Jill R Stewart, Elizabeth Pierce, Nora Pisanic, David C Love, Devon Hall, Jesper Larsen, Karen C Carroll, Tsigereda Tekle, Trish M Perl, Christopher D Heaney
Swine production work is a risk factor for nasal carriage of livestock-associated (LA-) Staphylococcus aureus and also for skin and soft tissue infection (SSTI). However, whether LA-S. aureus nasal carriage is associated with increased risk of SSTI remains unclear. We aimed to examine S. aureus nasal carriage and recent (≤3 months prior to enrollment) SSTI symptoms among industrial hog operation (IHO) workers and their household contacts. IHO workers and their household contacts provided a nasal swab and responded to a questionnaire assessing self-reported personal and occupational exposures and recent SSTI symptoms...
2016: PloS One
https://www.readbyqxmd.com/read/27847174/protective-efficacy-of-a-novel-alpha-hemolysin-subunit-vaccine-at62-against-staphylococcus-aureus-skin-and-soft-tissue-infections
#19
Rajan P Adhikari, Christopher D Thompson, M Javad Aman, Jean C Lee
Alpha hemolysin (Hla) is a pore-forming toxin produced by most Staphylococcus aureus isolates. Hla is reported to play a key role in the pathogenesis of staphylococcal infections, such as skin and soft tissue infection, pneumonia, and lethal peritonitis. This study makes use of a novel recombinant subunit vaccine candidate (AT62) that was rationally designed based on the Hla heptameric crystal structure. AT62 comprises a critical structural domain at the N terminus of Hla, and it has no inherent toxic properties...
December 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27843873/liver-abscess-in-a-boy-with-hyper-ige-syndrome
#20
Sneha Nandy, Ira Shah
Hyper immunoglobulin-E syndrome is a rare primary immunodeficiency disease, characterized by the classical triad of recurrent staphylococcal skin abscesses, pneumonia with pneumatocele formation, and elevated levels of serum IgE, usually over 2000 IU/mL. Chronic granulomatous disease, hyper IgE, and complement deficiencies are immunopathologies known to be associated with liver abscesses. We present a 2 ½-year-old boy with liver abscess and associated hyper IgE.
April 2016: Journal of Family Medicine and Primary Care
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