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Narayan Balaji, Suresh P Sulochana, Neeraj Kumar Saini, Siva Kumar A, Ramesh Mullangi
A simple, selective and reliable LC-MS/MS method was developed and validated for the simultaneous quantitation of darolutamide diastereomers (diastereomer-1 and diastereomer-2) and its active metabolite i. e. ORM-15341 in mice plasma using warfarin as an internal standard (IS) as per the regulatory guidelines. Plasma samples were extracted by liquid-liquid extraction and the chromatographic separation was achieved on a Chiralpak IA column with an isocratic mobile phase 5 mM ammonium acetate:absolute alcohol (20:80, v/v) at a flow rate of 1...
March 20, 2018: Drug Research
Rebecca J Beeken, Sundus Mahdi, Fiona Johnson, Susanne F Meisel
OBJECTIVES: This study investigates whether health and appearance consequences predict intentions to prevent weight gain and whether these relationships differ in younger versus older adults and in men versus women. METHODS: UK adults aged 18-26 years (younger adults; n = 584) or >45 years (older adults; n = 107) participated in an online survey. Logistic regression assessed associations between intentions to avoid gaining weight and age, gender as well as perceived negative consequences of weight gain for health and appearance...
March 21, 2018: Obesity Facts
Dolores Sánchez-Rodríguez, Cédric Annweiler, Natalia Ronquillo-Moreno, Andrea Tortosa-Rodríguez, Anna Guillén-Solà, Olga Vázquez-Ibar, Ferran Escalada, Josep M Muniesa, Ester Marco
BACKGROUND: Malnutrition is a prevalent condition related to adverse outcomes in older people. Our aim was to compare the diagnostic capacity of the malnutrition criteria of the European Society of Parenteral and Enteral Nutrition (ESPEN) with other classical diagnostic tools. METHODS: Cohort study of 102 consecutive in-patients ≥70 years admitted for postacute rehabilitation. Patients were considered malnourished if their Mini-Nutritional Assessment-Short Form (MNA-SF) score was ≤11 and serum albumin <3 mg/dL or MNA-SF ≤ 11, serum albumin <3 mg/dL, and usual clinical signs and symptoms of malnutrition...
March 16, 2018: Archives of Gerontology and Geriatrics
Rui Yamaguchi, Arisa Sakamoto, Reona Yamaguchi, Misa Haraguchi, Shinji Narahara, Hiroyuki Sugiuchi, Yasuo Yamaguchi
The stimuli inducing expression of single immunoglobulin IL-1-related receptor (SIGIRR) and the relevant regulatory mechanisms are not well defined. Transforming growth factor β1 (TGFβ1) delays internalization of neurokinin-1 receptor (NK1R) and subsequently enhances cellular signaling. This study investigated the effect of TGFβ1 on SIGIRR protein production by human M1 macrophages in response to stimulation with substance P (SP). SP caused upregulation of SIGIRR expression in a concentration-dependent manner, whereas aprepitant (an NK1R inhibitor) blunted this response...
March 17, 2018: Cytokine
Fatemeh Kiani, Negar Ashari Astani, Reza Rahighi, Ahmad Tayyebi, Meysam Tayebi, Jafar Khezri, Ehsan Hashemi, Ursula Rothlisberger, Abdolreza Simchi
In the present work, the effect of graphene oxide (GO) nanosheets on the antibacterial activity of CuO nanowire arrays under visible light irradiation is shown. A combined thermal oxidation/electrophoretic deposition technique was employed to prepare three-dimensional networks of graphene oxide nanosheets hybridized with vertically aligned CuO nanowires. With the help of standard antibacterial assays and X-ray photoelectron spectroscopy, it is shown that the light-activated antibacterial response of the hybrid material against gram-negative Escherichia coli is significantly improved as the oxide functional groups of the GO nanosheets are reduced...
March 7, 2018: Journal of Colloid and Interface Science
Karin Kfir-Elirachman, Rona Ortenberg, Bella Vizel, Michal J Besser, Iris Barshack, Jacob Schachter, Yael Nemlich, Gal Markel
BRAF becomes constitutively activated in 50% to 70% of melanoma cases. CEACAM1 has a dual role in melanoma, including facilitation of cell proliferation and suppression of infiltrating lymphocytes, which are consistent with its value as a marker for poor prognosis in melanoma patients. Here we show that BRAFV600E melanoma cells treated with BRAF and MEK inhibitors (MAPKi) downregulate CEACAM1 mRNA and protein expression in a dose- and exposure time-dependent manners. Indeed, there is a significant correlation between the presence of BRAFV600E and CEACAM1 expression in melanoma specimens obtained from 45 patients...
March 17, 2018: Neoplasia: An International Journal for Oncology Research
Yu-Jun Zheng, Xiao-Han Zhou, Wei-Guo Sheng, Yu Xue, Sheng-Yong Chen
Recently telecom fraud has become a serious problem especially in developing countries such as China. At present, it can be very difficult to coordinate different agencies to prevent fraud completely. In this paper we study how to detect large transfers that are sent from victims deceived by fraudsters at the receiving bank. We propose a new generative adversarial network (GAN) based model to calculate for each large transfer a probability that it is fraudulent, such that the bank can take appropriate measures to prevent potential fraudsters to take the money if the probability exceeds a threshold...
March 5, 2018: Neural Networks: the Official Journal of the International Neural Network Society
Joseph A Wonderlich, Lauren Breithaupt, James C Thompson, Ross D Crosby, Scott G Engel, Sarah Fischer
Stress and affect have been implicated in the maintenance of binge eating for women with symptoms of bulimia nervosa (BN). Neuroimaging and ecological momentary assessment (EMA) have separately examined how these variables may contribute to eating disorder behavior. Though both methodologies have their own strengths, it's unclear how either methodology might inform the other. This study examined the impact of individual differences in neural reactivity to food cues following acute stress on the trajectories of positive affect (PA) and negative affect (NA) surrounding binge eating...
March 14, 2018: Journal of Psychiatric Research
Samuel Silva Aguiar, Caio Victor Sousa, Herbert Gustavo Simões, Rodrigo Vanerson Passos Neves, Fernando Costa, Michel Kendy Souza, Milton Moraes, Jonato Prestes, Marcelo Magalhães Sales, Anderson Sola Haro, Jeffrey Michael Willardson, Thiago Dos Santos Rosa
Resistance exercise (RE) can be an excellent modality for glycemic control. Studies have demonstrated that a single RE session can reduce glycemia in subjects with or without diabetes. Little is known about the dose-response effect of RE on glycemic control. This study aimed to investigate the acute metabolic responses after different RE protocols. Eighty-nine men were separated into six groups that completed RE protocols: two sets of 18 repetitions (2x18 at 50% of 1RM; n=19); three sets of 12 repetitions (3x12 at 70% of 1RM; n=14); four sets of nine repetitions (4x9 at 80% of 1RM; n=13); six sets of six repetitions (6x6 at 90% of 1RM; n=19); circuit (2x18 at 50% of 1RM; n=12); and a control session (n=12)...
March 20, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Lei Hu, Feiyu Qin, Andrea Sanson, Liang-Feng Huang, Zhao Pan, Qiang Li, Qiang Sun, Lu Wang, Fangming Guo, Umut Aydemir, Yang Ren, Chengjun Sun, Jinxia Deng, Giuliana Aquilanti, James M Rondinelli, Jun Chen, Xianran Xing
The local symmetry, beyond the averaged crystallographic structure, tends to bring unusual performances. Negative thermal expansion is a peculiar physical property of solids. Here, we report the delicate design of the localized symmetry breaking to achieve the controllable thermal ex-pansion in ScF3 nano-scale frameworks. Intriguingly, an iso-tropic zero thermal expansion is concurrently engineered by localized symmetry breaking, with a remarkably low coefficient of thermal expansion of about +4.0×10-8/K up to 675K...
March 20, 2018: Journal of the American Chemical Society
Karina Panczyk, Karolina Gaweda, Mateusz Drach, Wojciech Plazinski
An extension of the GROMOS 56a6CARBO/CARBO_R force field for hexopyranose-based carbohydrates is presented. The additional parameters describe the conformational properties of uronate residues. The three distinct chemical states of the carboxyl group are considered: deprotonated (negatively charged), protonated (neutral) and esterified (neutral). The parameterization procedure was based on quantum-chemical calculations and the resulting parameters were tested in the context of: (i) flexibility of the pyranose rings under different pH conditions; (ii) conformation of the glycosidic linkage of the (1→4)-type for uronates with different chemical states of carboxyl moieties; (iii) conformation of the exocyclic (i...
March 20, 2018: Journal of Physical Chemistry. B
Barnabas Ohst, Brunna Tuschen-Caffier
The catastrophic misinterpretation model of panic disorder (PD) predicts that the catastrophic misinterpretation of bodily sensations is a distinctive characteristic of PD. Existing research on this prediction has produced mixed findings. This paper presents a systematic review and meta-analysis of studies comparing the strength of catastrophic misinterpretation of bodily sensations and external events in patients with PD, patients with other anxiety disorders, and healthy controls. Following a systematic screening, seven studies were included in the meta-analysis...
2018: PloS One
Jie Liu, Shengquan Mi, Li Du, Xiang Li, Peiqin Li, Keyu Jia, Jing Zhao, Hong Zhang, Wenhua Zhao, Ying Gao
Metabolic syndrome (MetS) has become an important issue in the healthcare systems of both developed and developing countries. Phytoestrogens have shown estrogenic effects, which may involve in the etiology of MetS. The current study consisted of 293 MetS cases and 264 healthy controls. The concentrations of seven plasma phytoestrogens (daidzein, genistein, glycitein, equol, enterolactone, enterodiol and coumestrol) were detected by UPLC-MS/MS. Adjusted unconditional logistic regression was used to assess the associations between plasma phytoestrogens concentration and risks of MetS, as well as the associations between plasma phytoestrogens concentration and MetS components...
2018: PloS One
Anaid Rosas-Navarro, Gerald Langer, Patrizia Ziveri
The sinking properties of three strains of Emiliania huxleyi in response to temperature changes were examined. We used a recently proposed approach to calculate sinking velocities from coccosphere architecture, which has the advantage to be applicable not only to culture samples, but also to field samples including fossil material. Our data show that temperature in the sub-optimal range impacts sinking velocity of E. huxleyi. This response is widespread among strains isolated in different locations and moreover comparatively predictable, as indicated by the similar slopes of the linear regressions...
2018: PloS One
Balaram Mohapatra, Pinaki Sar, Sufia Khannam Kazy, Mrinal Kumar Maiti, Tulasi Satyanarayana
Reductive transformation of toxic arsenic (As) species by As reducing bacteria (AsRB) is a key process in As-biogeochemical-cycling within the subsurface aquifer environment. In this study, we have characterized a Gram-stain-negative, non-spore-forming, rod-shaped As reducing bacterium designated KAs 5-3T, isolated from highly As-contaminated groundwater of India. Strain KAs 5-3T displayed high 16S rRNA gene sequence similarity to the members of the genus Pseudoxanthomonas, with P. mexicana AMX 26BT (99.25% similarity), P...
2018: PloS One
Marcin Procek, Kinga Kepska, Agnieszka Stolarczyk
The detection and concentration measurements of low concentrations of nitrogen dioxide (NO₂) are important because of its negative effects on human health and its application in many fields of industry and safety systems. In our approach, conducting graft copolymers based on the poly(3-hexylthiophene) (P3HT) conducting polymer and other side-chains, polyethylene glycol (PEG) and dodec-1-en, grafted on a poly(methylhydrosiloxane) backbone, were investigated. The grafts containing PEG (PEGSil) and dodec-1-en (DodecSil) in two variants, namely, fractions with shorter (hexane fraction -H) and longer (chloroform fraction -CH) side-chains of P3HT, were tested as receptor structures in NO₂ gas sensors...
March 20, 2018: Sensors
Chengwu Yang, Kent E Vrana
Background : Psychometric instruments such as the Repeated Battery for the Assessment of Neuropsychological Status (RBANS) are commonly used under conditions for which they were not developed or validated. They may then generate troublesome data that could conceal potential findings. Methods : Based on a previously published refinement of the RBANS, we reanalyzed the data on 303 patients from two National Institutes of Health (NIH) trails in Parkinson's disease and contrasted the results using the original versus refined scores...
March 20, 2018: Healthcare (Basel, Switzerland)
Quanwei Zhang, Qi Wang, Jishang Gong, Jiaxing Du, Yong Zhang, Xingxu Zhao
Insulin-like growth factor 2 (IGF2) recapitulates many of the activities of insulin and promotes differentiation of myoblasts and osteoblasts, which likely contribute to genetic variations of growth potential. However, little is known about the functions and signaling properties of IGF2 variants in yaks. The over-expression vector and knockdown sequence of yak IGF2 were transfected into yak fibroblasts, and the effects were detected by a series of assays. IGF2 expression in yak muscle tissues was significantly lower than that of other tissues...
March 20, 2018: Genes
Maria Spies, Jakub Polaczynski, Akhil Ajay, Dipankar Kalita, Jonas Lähnemann, Bruno Gayral, Martien den Hertog, Eva Monroy
Nanowire photodetectors are investigated because of their compatibility with flexible electronics, or for the implementation of on-chip optical interconnects. Such devices are characterized by ultrahigh photocurrent gain, but their photoresponse scales sublinearly with the optical power. Here, we present a study of single-nanowire photodetectors displaying a linear response to ultraviolet illumination. Their structure consists of a GaN nanowire incorporating an AlN/GaN/AlN heterostructure, which generates an internal electric field...
March 20, 2018: Nanotechnology
Aleksandra Szuster, Justyna Tyburek, Karolina Widłak, Piotr Wilkołek, Karol Wiśniewski, Maria Majdan
The coexistence of systemic lupus erythematosus (SLE) and psoriasis is rarely observed in everyday clinical practice. Apart from providing a correct diagnosis, a major difficulty is to provide a proper treatment. In this case, for example, the use of systemic glucocorticosteroids may have a negative effect on the course of psoriasis, whereas phototherapy, which is widely practiced in psoriasis, may cause SLE exacerbation. The aim of the paper is to present the difficulty along the diagnostic process and in choosing the best type of treatment for patients with a coexistence of SLE and psoriasis and also a review of the subject-related literature...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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