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markers in chronic kidney disease

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https://www.readbyqxmd.com/read/29227975/high-phosphate-induced-calcification-of-vascular-smooth-muscle-cells-is-associated-with-the-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#1
Daohai Zhang, Xianjin Bi, Yong Liu, Yinghui Huang, Jiachuan Xiong, Xinli Xu, Tangli Xiao, Yanlin Yu, Wei Jiang, Yunjian Huang, Jingbo Zhang, Bo Zhang, Jinghong Zhao
BACKGROUND/AIMS: Hyperphosphatemia is one of the most notable features of chronic kidney disease (CKD). Numerous epidemiological and clinical studies have found that high serum phosphate concentrations are associated with calcification in the coronary arteries. However, the mechanisms underlying the vascular calcification induced by high phosphate have not been understood fully. METHODS: Vascular smooth muscle cells (VSMCs) were cultured in high-phosphate media to induce vascular calcification, which was detected by Alizarin red S staining...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29226693/higher-pulse-pressure-and-risk-for-cardiovascular-events-in-patients-with-essential-hypertension-the-campania-salute-network
#2
Costantino Mancusi, Maria A Losi, Raffaele Izzo, Grazia Canciello, Maria V Carlino, Giovanni Albano, Nicola De Luca, Bruno Trimarco, Giovanni de Simone
Background Increased pulse pressure is associated with structural target organ damage, especially in elderly patients, increasing cardiovascular risk. Design In this analysis, we investigated whether high pulse pressure retains a prognostic effect also when common markers of target organ damage are taken into account. Methods We analysed an unselected cohort of treated hypertensive patients from the Campania Salute Network registry ( n = 7336). Participants with available cardiac and carotid ultrasound were required to be free of prevalent cardiovascular disease, with ejection fraction ≥50%, and no more than stage III Chronic Kidney Disease...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29225808/symptom-burden-in-patients-with-chronic-kidney-disease-not-requiring-renal-replacement-therapy
#3
Stephanie A Brown, Freya C Tyrer, Amy L Clarke, Laetitia H Lloyd-Davies, Andrew G Stein, Carolyn Tarrant, James O Burton, Alice C Smith
Background: Although evidence shows that patients with end stage renal disease (ESRD) experience a high symptom burden which impacts on quality of life (QoL), less is known about patients with earlier stages of chronic kidney disease (CKD). This study aimed to explore symptom burden and potential contributing factors in patients with CKD Stage 1-5 not requiring renal replacement therapy (RRT). Methods: Patients with CKD Stage 1-5 and not on RRT were asked to report their symptoms using the Leicester Uraemic Symptom Score (LUSS), a questionnaire which assesses the frequency and intrusiveness of 11 symptoms commonly reported by kidney patients...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29225804/angiotensinogen-as-a-biomarker-of-acute-kidney-injury
#4
REVIEW
Sheeba Habeeb Ba Aqeel, Alejandro Sanchez, Daniel Batlle
Early recognition of acute kidney injury (AKI) is critical to prevent its associated complications as well as its progression to long term adverse outcomes like chronic kidney disease. A growing body of evidence from both laboratory and clinical studies suggests that inflammation is a key factor contributing to the progression of AKI regardless of the initiating event. Biomarkers of inflammation are therefore of interest in the evaluation of AKI pathogenesis and prognosis. There is evidence that the renin angiotensin aldosterone system is activated in AKI, which leads to an increase in angiotensin II (Ang II) formation within the kidney...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29225799/kidney-involvement-in-the-schnitzler-syndrome-a-rare-disease
#5
REVIEW
Carlo Basile, Luigi Rossi, Francesco Casucci, Annalisa Teutonico, Pasquale Libutti, Piero Lisi, Carlo Lomonte, Raffaele Manna
The Schnitzler syndrome (SS) is a rare and underdiagnosed entity that associates a chronic urticarial rash, monoclonal IgM (or sometimes IgG) gammopathy and signs and symptoms of systemic inflammation. During the past 45 years, the SS has evolved from an elusive little-known disorder to the paradigm of a late-onset acquired auto-inflammatory syndrome. Though there is no definite proof of its precise pathogenesis, it should be considered as an acquired disease involving abnormal stimulation of the innate immune system, which can be reversed by the interleukin-1 receptor antagonist anakinra...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29219791/effects-of-the-vitamin-d-analog-2amd-in-cyclosporine-induced-nephrotoxicity-dose-response-and-antifibrotic-activity
#6
Bianca Tomasini-Johansson, Cori O'Brien, Alexandra Larson-Osborne, Inger Toraason, Debra Hullett, Lori Plum, Hector DeLuca, Hans Sollinger
OBJECTIVES: In this study, we aimed to ascertain the efficacy and determine the dose effects of a new analog of vitamin D, 2α-methyl-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2AMD), in decreasing fibrosis and improving renal function in a rat model of kidney disease. MATERIALS AND METHODS: Using the cyclosporine model of chronic kidney disease, we tested 4 dose regimens (2.5, 5, 10, and 20 ng/kg) of 2AMD by subcutaneous administration. The 2AMD analog was compared with another analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2MD), given at 5 ng/kg...
December 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29218485/apical-membrane-alterations-in-non-intestinal-organs-in-microvillus-inclusion-disease
#7
Cameron Schlegel, Victoria G Weis, Byron C Knowles, Lynne A Lapierre, Martin G Martin, Paul Dickman, James R Goldenring, Mitchell D Shub
OBJECTIVES: Microvillus inclusion disease (MVID) is a severe form of neonatal diarrhea, caused mainly by mutations in MYO5B. Inactivating mutations in MYO5B causes depolarization of enterocytes in the small intestine, which gives rise to chronic, unremitting secretory diarrhea. While the pathology of the small intestine in MVID patients is well described, little is known about extraintestinal effects of MYO5B mutation. METHODS: We examined stomach, liver, pancreas, colon, and kidney in Navajo MVID patients, who share a single homozygous MYO5B-P660L (1979C>T p...
December 7, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29215435/noninvasive-fibrosis-markers-and-chronic-kidney-disease-among-adults-with-nonalcoholic-fatty-liver-in-usa
#8
Karn Wijarnpreecha, Charat Thongprayoon, Melissa Scribani, Patompong Ungprasert, Wisit Cheungpasitporn
BACKGROUND/AIMS: Studies have shown that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of chronic kidney disease (CKD). However, it is unknown whether severe liver fibrosis is associated with a higher prevalence of CKD among NAFLD. We examined the diagnostic performance of noninvasive fibrosis markers in identifying prevalent CKD among NAFLD. METHODS: This study represents an analysis of the National Health and Nutrition Examination Survey conducted in the USA between 1988 and 1994...
December 5, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29214305/cardiovascular-outcomes-according-to-urinary-albumin-and-kidney-disease-in-patients-with-type-2-diabetes-at-high-cardiovascular-risk-observations-from-the-savor-timi-53-trial
#9
Benjamin M Scirica, Ofri Mosenzon, Deepak L Bhatt, Jacob A Udell, Ph Gabriel Steg, Darren K McGuire, KyungAh Im, Estella Kanevsky, Christina Stahre, Mikaela Sjöstrand, Itamar Raz, Eugene Braunwald
Importance: An elevated level of urinary albumin to creatinine ratio (UACR) is a marker of renal dysfunction and predictor of kidney failure/death in patients with type 2 diabetes. The prognostic use of UACR in established cardiac biomarkers is not well described. Objective: To evaluate whether UACR offers incremental prognostic benefit beyond risk factors and established plasma cardiovascular biomarkers. Design, Setting, and Participants: The Saxagliptin Assessment of Vascular Outcomes Recorded in Patients With Diabetes Mellitus-Thrombolysis in Myocardial Infarction (SAVOR-TIMI) 53 study was performed from May 2010 to May 2013 and evaluated the safety of saxagliptin vs placebo in patients with type 2 diabetes with overt cardiovascular disease or multiple risk factors...
December 6, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29211778/clinical-global-assessment-of-nutritional-status-as-predictor-of-mortality-in-chronic-kidney-disease-patients
#10
Lu Dai, Hideyuki Mukai, Bengt Lindholm, Olof Heimbürger, Peter Barany, Peter Stenvinkel, Abdul Rashid Qureshi
BACKGROUND: The value of subjective global assessment (SGA) as nutritional assessor of protein-energy wasting (PEWSGA) in chronic kidney disease (CKD) patients depends on its mortality predictive capacity. We investigated associations of PEWSGA with markers of nutritional status and all-cause mortality in CKD patients. METHODS: In 1031 (732 CKD1-5 non-dialysis and 299 dialysis) patients, SGA and body (BMI), lean (LBMI) and fat (FBMI) body mass indices, % handgrip strength (% HGS), serum albumin, and high sensitivity C-reactive protein (hsCRP) were examined at baseline...
2017: PloS One
https://www.readbyqxmd.com/read/29209440/efficacy-of-fenugreek-based-bionanocomposite-on-renal-dysfunction-and-endogenous-intoxication-in-high-calorie-diet-induced-obesity-rat-model-comparative-study
#11
Victoria V Konopelniuk, Ievgenii I Goloborodko, Tetyana V Ishchuk, Tetyana B Synelnyk, Ludmila I Ostapchenko, Mykola Ya Spivak, Rostyslav V Bubnov
Background: Worldwide obesity spread is a global health problem and needs to be further studied. Co-morbidities of obesity include insulin resistance, diabetes mellitus type 2, and dyslipidemia, which are the most frequent contributing factors for metabolic syndrome (MetS), as well as non-alcoholic fatty liver disease and chronic kidney disease. The aim was to study renal function and endogenous intoxication panel on high-calorie diet-induced obesity rat model and perform comparative study of the treatment efficacy of Fenugreek-based bionanocomposite vs antiobesogenic drugs (Orlistat)...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29207220/-long-term-outcome-of-renal-function-in-women-with-preeclampia-and-pregestational-diabetes
#12
REVIEW
Carmela Vadalà, Valeria Cernaro, Rossella Siligato, Roberta Granese, Antonio Simone Laganà, Michele Buemi, Domenico Santoro
Pre-eclampsia (PE) is an important cause of acute renal failure and an important risk marker for subsequent chronic kidney disease. In normal pregnancy, there are marked changes in the renin-angiotensin system (RAS) including considerably elevated angiotensin II (ang II) levels. However, vascular resistance decreases markedly during normal pregnancy, suggesting that pregnant individuals are less sensitive to ang II than non-pregnant individuals. In contrast, during PE decreased circulating components of the RAS with enhanced sensitivity of ang II infusion have been reported...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29205940/relation-of-serum-adma-apelin-13-and-lox-1-levels-with-inflammatory-and-echocardiographic-parameters-in-hemodialysis-patients
#13
Ibrahim Dogan, Tolga Dogan, Mucahit Yetim, Huseyin Kayadibi, Mehmet B Yilmaz, Baris Eser, Macit Kalcik, Yusuf Karavelioglu
Cardiovascular diseases are the leading causes of mortality in patients with chronic kidney disease. Nitric oxide has a critical role in both endothelial dysfunction and the atherosclerosis process. We aimed to investigate the relationships between serum asymmetric dimethyl arginine (ADMA), LOX-1, and Apelin-13 levels, which are known to act over nitric oxide with endothelial dysfunction and cardiac morphology as well as with each other in hemodialysis patients. The study comprised a total of 120 patients (53 females and 67 males) receiving hemodialysis three times a week for at least 6 months and an age-gender matched control group (55 females and 58 males)...
December 4, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29205514/acute-kidney-injury-impact-on-inpatient-mortality-in-clostridium-difficile-infection-a-national-propensity-matched-study
#14
Paris Charilaou, Kalpit Devani, Febin John, Sowjanya Kanna, Sushil Ahlawat, Mark Young, Sahil Khanna, Chakradhar Reddy
OBJECTIVE: Acute kidney injury (AKI) is used as a marker of severity in Clostridium difficile infection (CDI) patients. We estimated the true effect of AKI in inpatient mortality of CDI patients, as there are no large-scale, population-based, propensity-matched studies evaluating AKI's effect in this patient cohort. METHODS: A retrospective observational study utilizing the National Inpatient Sample (NIS) from years 2003-2012, including all adults with CDI, excluding cases missing data on age, inpatient mortality or gender...
December 4, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29205452/an-r2-curve-for-evaluating-the-accuracy-of-dynamic-predictions
#15
Marie-Cécile Fournier, Etienne Dantan, Paul Blanche
In the context of chronic diseases, patient's health evolution is often evaluated through the study of longitudinal markers and major clinical events such as relapses or death. Dynamic predictions of such types of events may be useful to improve patients management all along their follow-up. Dynamic predictions consist of predictions that are based on information repeatedly collected over time, such as measurements of a biomarker, and that can be updated as soon as new information becomes available. Several techniques to derive dynamic predictions have already been suggested, and computation of dynamic predictions is becoming increasingly popular...
December 4, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29203632/uric-acid-is-a-strong-risk-marker-for-developing-hypertension-from-prehypertension-a-5-year-japanese-cohort-study
#16
Masanari Kuwabara, Ichiro Hisatome, Koichiro Niwa, Shigeko Hara, Carlos A Roncal-Jimenez, Petter Bjornstad, Takahiko Nakagawa, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Gabriela Garcia, Bernardo Rodriguez-Iturbe, Minoru Ohno, Miguel A Lanaspa, Richard J Johnson
Prehypertension frequently progresses to hypertension, a condition associated with high morbidity and mortality from cardiovascular diseases and stroke. However, the risk factors for developing hypertension from prehypertension remain poorly understood. We conducted a retrospective cohort study using the data from 3584 prehypertensive Japanese adults (52.1±11.0 years, 2081 men) found to be prehypertensive in 2004 and reexamined in 2009. We calculated the cumulative incidences of hypertension over 5 years, examined risk factors, and calculated odds ratios (ORs) for developing hypertension after adjustments for age, sex, body mass index, smoking and drinking habits, baseline systolic and diastolic blood pressure, pulse rate, diabetes mellitus, dyslipidemia, chronic kidney disease, and serum uric acid levels...
December 4, 2017: Hypertension
https://www.readbyqxmd.com/read/29199508/wrist-inflammation-a-retrospective-comparison-between-septic-and-non-septic-arthritis
#17
Gavrielle Kang, Mabel Q H Leow, Shian-Chao Tay
This study aims to identify differences in demographics, clinical and laboratory data between wrist septic arthritis and non-septic arthritis in patients admitted for wrist inflammation. A retrospective review of inpatients from May 2012 to April 2015 was conducted. Seventy-seven patients were included. Non-septic arthritis patients were more likely to have chronic kidney disease, pre-existing gout, or both. All septic arthritis patients had normal serum uric acid levels, and two or more raised inflammatory markers (white cell count, C-reactive protein, erythrocyte sedimentation rate)...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29190606/association-between-klotho-gene-polymorphism-and-markers-of-bone-metabolism-in-patients-receiving-maintenance-hemodialysis-in-iran
#18
Aboalfazl Nazarian, Meisam Hasankhani, Monireh Aghajany-Nasab, Ali Monfared
INTRODUCTION: Some genetic variations of Klotho have been reported as a risk factor for calcification and hyperphosphatemia in chronic kidney disease. Klotho polymorphism is also associated with outcome in patients receiving hemodialysis. This study aimed to evaluate the relationship between Klotho single nucleotide polymorphism (SNP) and bone metabolism as an early prognostic measure for chronic kidney disease.   Materials and Methods. Sixty patients receiving hemodialysis and 60 age-matched controls were enrolled in the study of the assessment of 2 types of Klotho polymorphism (G395A and C1818T)...
November 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29190600/hyaluronic-acid-as-a-new-biomarker-to-differentiate-acute-kidney-injury-from-chronic-kidney-disease
#19
Davut Akin, Sehmus Ozmen, Mehmet Emin Yilmaz
INTRODUCTION: It may be difficult to differentiate acute kidney injury from chronic kidney disease in patients with no past medical reports of kidney function. This study aimed to investigate the role of serum hyaluronic acid (HA), which is known as a marker of fibrosis, in differential diagnosis of kidney failure. MATERIALS AND METHODS: A total of 90 patients (52 women and 38 mne) admitted to our renal unit with uremia for the first time were included. Serum HA level was measured...
November 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29189482/analysis-of-biomarkers-within-the-initial-2-years-posttransplant-and-5-year-kidney-transplant-outcomes-results-from-clinical-trials-in-organ-transplantation-17
#20
Geovani Faddoul, Girish N Nadkarni, Nancy D Bridges, Jens Goebel, Donald E Hricik, Richard Formica, Madhav C Menon, Yvonne Morrison, Barbara Murphy, Kenneth Newell, Peter Nickerson, Emilio D Poggio, David Rush, Peter S Heeger
BACKGROUND: An early posttransplant biomarker/surrogate marker for kidney allograft loss has the potential to guide targeted interventions. Previously published findings, including results from the Clinical Trials in Organ Transplantation (CTOT)-01 study, showed that elevated urinary chemokine CXCL9 levels and elevated frequencies of donor-reactive interferon gamma-(IFNγ)-producing T cells by enzyme linked immunosorbent spot (ELISPOT) assay associated with acute cellular rejection within the first year and with lower 1-year posttransplant estimated glomerular filtration rate (eGFR)...
November 20, 2017: Transplantation
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