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https://www.readbyqxmd.com/read/29785414/topical-nasal-decongestant-oxymetazoline-0-05-provides-relief-of-nasal-symptoms-for-12-hours
#1
H M Druce, D L Ramsey, S Karnati, A N Carr
BACKGROUND: Nasal congestion, often referred to as stuffy nose or blocked nose is one of the most prevalent and bothersome symptoms of an upper respiratory tract infection. Oxymetazoline, a widely used intranasal decongestant, offers fast symptom relief, but little is known about the duration of effect. METHODOLOGY: The results of 2 randomized, double-blind, vehicle-controlled, single-dose, parallel, clinical studies (Study 1, n=67; Study 2, n=61) in which the efficacy of an oxymetazoline (0...
May 22, 2018: Rhinology
https://www.readbyqxmd.com/read/29782182/a-specifically-designed-multispecies-probiotic-supplement-relieves-seasonal-allergic-rhinitis-symptoms
#2
Annabelle M Watts, Amanda J Cox, Peter K Smith, Isolde Besseling-van der Vaart, Allan W Cripps, Nicholas P West
BACKGROUND: Probiotics are purported to reduce symptoms of allergic rhinitis. This study sought to determine the proportion of participants with an improvement in the mini Rhinoconjunctivitis Quality of Life Questionnaire (mRQLQ) in response to a multispecies probiotic supplement with a Simon Two-Stage design. METHODS: This study was based on a Simon Two-Stage Design for p1 -p0  = 0.18 to account for seasonal variation in symptoms. Under this design, ≥10 patients are required to exhibit an improvement in quality-of-life scores to determine that there was sufficient activity for the supplement to be considered effective...
May 21, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29775557/symptoms-of-obstructive-sleep-apnea-nasal-obstruction-and-enuresis-in-children-with-nonsyndromic-cleft-lip-and-palate-a-prevalence-study
#3
Marilyse de Bragança Lopes Fernandes, Alícia Graziela Noronha Silva Salgueiro, Eliete Janaína Bueno Bighetti, Ivy Kiemle Trindade-Suedam, Inge Elly Kiemle Trindade
OBJECTIVE: To estimate the prevalence of symptoms of obstructive sleep apnea (OSA), nasal obstruction, and enuresis in children with nonsyndromic unilateral cleft lip and palate. DESIGN: Prospective cross-sectional study. SETTING: Referral care center. PARTICIPANTS: One hundred seventy-four children aged 6 to 12 years of both genders. INTERVENTIONS: Symptoms of OSA and nasal obstruction were investigated by analysis of scores obtained by the Sleep Disturbance Scale for Children (SDSC) and Congestion Quantifier (CQ-5)...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29775017/-study-on-the-relationship-between-nasal-and-eye-symptoms-and-psychological-status-in-patients-with-allergic-rhinitis
#4
X He, Y Y Dong, Y Feng, B Q Wang
Objective: The aim of this study is to analysis the correlation between nasal and eye symptom and psychological status in patients with allergic rhinitis, in order to provide a basis for improving the mental health of patients. Method: The nasal symptom score scale, eye symptom score scale and Kessler 10 were used in the study, and the survey data was analyzed. Result: At least one of 147 patients had a nasal symptom at a rate of 100% (147/147); at least one ocular symptom was 86.4% (127/147). Of the 147 patients, 29 had K10 scores more than 21...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775013/-effects-of-highly-selective-branches-neurotomy-of-vidian-nerve-with-low-temperature-plasma-on-vasoactive-intestinal-peptide-in-nasal-mucosal-cells-of-patients-with-allergic-rhinitis
#5
P He, X J Jin, H Zhao
Objective: The aim of this study is to investigate the effect of highly selective branches neurotomy of vidian nerve with low temperature plasma on the level of vasoactive intestinal peptide in nasal mucosa of patients with allergic rhinitis. Method: Fifty patients with allergic rhinitis were selected as the experimental group. At the same time, 50 normal adults in our hospital were selected as the control group. Highly selective branches neurotomy of vidian nerve with low temperature plasma was performed to observe the changes of vascular intestinal peptide levels in patients with nasal mucosa and the clinical efficacy...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29765824/changing-trends-in-the-management-of-esthesioneuroblastoma-irish-and-international-perspectives
#6
Robbie S R Woods, Thavakumar Subramaniam, Mary Leader, Rory McConn-Walsh, James Paul O'Neill, Peter D Lacy
Objectives  Evaluation of the changing trends in esthesioneuroblastoma in an Irish context and review of management options nationally to clarify the best current therapeutic approach by comparing with international research on this uncommon malignancy. Design  Retrospective review. Setting  Tertiary referral center. Participants  All patients presenting with esthesioneuroblastoma in Beaumont hospital or on the National Cancer Registry of Ireland between 1994 and 2013. Main Outcome Measures  Recurrence-free and overall survival...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29750825/cyclamen-europaeum-extract-for-acute-sinusitis
#7
REVIEW
Anca Zalmanovici Trestioreanu, Ankur Barua, Barak Pertzov
BACKGROUND: Acute sinusitis is a common reason for primary care encounters. It causes significant symptoms including facial pain, congested nose, headache, thick nasal mucus, fever, and cough and often results in time off work or school. Sinusitis treatment focuses on eliminating causative factors and controlling the inflammatory and infectious components. The frozen, dried, natural fluid extract of the Cyclamen europaeum plant delivered intranasally is thought to have beneficial effects in relieving congestion by facilitating nasal drainage, and has an anti-inflammatory effect...
May 11, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29744638/effects-of-trigeminal-training-on-trigeminal-sensitivity-and-self-rated-nasal-patency
#8
Anna Oleszkiewicz, Timo Schultheiss, Valentin A Schriever, Jana Linke, Mandy Cuevas, Antje Hähner, Thomas Hummel
PURPOSE: Patients with the feeling of a congested nose not always suffer from an anatomical obstruction but might just have a low trigeminal sensibility, which prevents them from perceiving the nasal airstream. We examined whether intermittent trigeminal stimulation increases sensitivity of the nasal trigeminal nerve and whether this effect is accompanied by subjective improvement of nasal breathing. METHOD: Thirty-five patients (Mage  = 58.4 years; SD = 14...
May 9, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29738635/nasopharyngeal-versus-hypopharyngeal-packing-during-sino-nasal-surgeries-randomized-controlled-trial
#9
Mohamed G Alfiky, Osama A Margalani, Afnan F Rajeh, Fares E Alghamdi, Omar A Abu Suliman, Sumaiya H Muathen, Soha A Elmorsy
OBJECTIVES: Primary: to compare the severity of postoperative throat pain between patients who received a nasopharyngeal pack, and those who received a hypopharyngeal pack during their sino-nasal surgery. Secondary: to assess the efficacy of using a nasopharyngeal pack in preventing postoperative nausea and vomiting (PONV) and to compare its result with patients who received a hypopharyngeal pack. DESIGN: Prospective, randomized, controlled trial. SETTING: Tertiary Hospital...
May 8, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29737501/safety-of-tamsulosin-a-systematic-review-of-randomized-trials-with-a-focus-on-women-and-children
#10
REVIEW
Steven A Kaplan, Bilal I Chughtai
INTRODUCTION: Although tamsulosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH), it has also been assessed in clinical studies for other conditions/symptoms and in other populations such as women and children. In this systematic review of randomized studies, the overall safety of tamsulosin was assessed, focusing on these understudied populations. METHODS: Literature searches were conducted using Embase, Medline, and PubMed (inception-December 2015)...
May 8, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29702978/optic-neuropathy-causing-vertical-unilateral-hemianopsia-after-pars-plana-vitrectomy-for-a-macular-hole-a-case-report
#11
Hirohiko Kawashima, Norihiro Nagai, Hajime Shinoda, Kazuo Tsubota, Yoko Ozawa
INTRODUCTION: Recent progress in medical technology has resulted in improved surgical outcomes of pars plana vitrectomy (PPV); with microincision systems, the incidence of procedure-related complications during surgery has been reduced. However, unpredictable visual field defects after PPV remain an unresolved issue. A few reports have shown that damage to the retinal neurofibers owing to dry-up during air/fluid exchange or retinal neurotoxicity of the dye used to visualize the internal limiting membrane (ILM), as well as unintentional removal of retinal neurofibers during ILM peeling, are responsible for such visual field disorders...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29671128/a-phase-i-study-of-the-pharmacokinetics-and-pharmacodynamics-of-intranasal-doxylamine-in-subjects-with-chronic-intermittent-sleep-impairment
#12
Mark Allison, Cecilia Hale
INTRODUCTION: Doxylamine tablets are approved as an over-the-counter sleep aid. We developed a doxylamine succinate intranasal metered-dose delivery system with the expectation of a more rapid onset of action with reduced side-effect potential compared with the oral tablet. METHODS: This phase I study randomized 24 adults with chronic intermittent sleep impairment to receive either single doses of intranasal doxylamine succinate 3.2, 6.3, or 12.7 mg or doxylamine succinate 25-mg oral tablet...
April 18, 2018: Drugs in R&D
https://www.readbyqxmd.com/read/29669663/nonprescription-medications-for-respiratory-symptoms-facts-and-marketing-fictions
#13
Miles Weinberger, Leslie Hendeles
BACKGROUND: There are many nonprescription (over-the-counter [OTC]) medications available on pharmacy shelves marketed for relief of respiratory symptoms. The number of such medications has been increasing. OBJECTIVE: This review provides an evidence-based examination of OTC products used for respiratory symptoms. METHODS: Antihistamines, decongestants, mucolytics, antitussives, and intranasal steroids were selected as the most common OTC medications taken by adults and children for various respiratory symptoms...
May 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29629288/natural-therapeutic-approach-of-nigella-sativa-black-seed-fixed-oil-in-management-of-sinusitis
#14
REVIEW
Mohaddese Mahboubi
Sinusitis is associated with inflammation and infections of air-filled cavities of sinuses. The aim of this study was to evaluate the potential efficacy of Nigella sativa seed fixed oil in management of sinusitis. The information was extracted from accessible international databases, traditional books, electronic resources, and unpublished data. Results: The results of investigations on N. sativa seed fixed oil showed its therapeutic potential in treatment of sinusitis by its anti-inflammatory, antioxidant, antihistaminic, immune-modulator, antimicrobial and analgesic effects...
March 2018: Integrative Medicine Research
https://www.readbyqxmd.com/read/29626629/the-burden-of-allergic-rhinitis-and-allergic-rhinoconjunctivitis-on-adolescents-a-literature-review
#15
REVIEW
Michael S Blaiss, Eva Hammerby, Susan Robinson, Tessa Kennedy-Martin, Sarah Buchs
OBJECTIVE: To evaluate the literature regarding the burden of allergic rhinitis (AR) and allergic rhinoconjunctivitis (ARC) in adolescents (10-19 years). DATA SOURCES: Searches were performed in MEDLINE, Embase, Health Technology Assessment Database, and National Health Service Economic Evaluation Database for studies evaluating concepts of symptoms, quality of life (QOL), daily activities, sleep, examination performance, school absenteeism and presenteeism, and treatment burden in adolescents with AR or ARC...
April 4, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29619104/the-role-of-the-level-of-interleukin-33-in-the-therapeutic-outcomes-of-immunotherapy-in-patients-with-allergic-rhinitis
#16
Wail Fayez Nasr, Samir Sorour Sorour, Atef Taha El Bahrawy, Ghada Samir Boghdadi, Alia A El Shahaway
Introduction  Allergic rhinitis (AR) affects up to 40% of the population and results in nasal itching, congestion, sneezing, and clear rhinorrhea. Objectives  This study aimed to evaluate the changes in the clinical symptoms and in the level of serum interleukin (IL)-33 before and after pollen immunotherapy (IT) in patients with AR. Methods  The total symptom score and the levels of total immunoglobulin E (IgE) and IL-33 were determined in the serum of 10 non-allergic healthy controls and 45 patients with AR who were equally divided into 3 groups: GI (patients did not receive IT), GII (patients had received IT for 6 months) and GIII (patients had received IT for 2 years)...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29615844/bepotastine-besilate-ophthalmic-solution-1-5-for-alleviating-nasal-symptoms-in-patients-with-allergic-conjunctivitis
#17
Megan E Cavet, Paul J Gomes, Warner W Carr, Jon I Williams
Background: Bepotastine besilate ophthalmic solution (BBOS) 1.5% is a topical antihistamine for the treatment of ocular itching associated with allergic conjunctivitis (AC). Allergic rhinitis and AC are common comorbid conditions. We explored the efficacy of BBOS 1.5% in alleviating nasal symptoms in an integrated analysis of two Phase III conjunctival allergen challenge (CAC) studies and a Phase IV environmental allergen study. Methods: In the Phase III trials, a CAC was performed 15 minutes, 8 hours, and 16 hours following ocular instillation of BBOS 1...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29605347/diagnosis-and-management-of-pediatric-sinusitis-a-survey-of-primary-care-otolaryngology-and-urgent-care-providers
#18
Laurie Newton, Amanda Kotowski, Melissa Grinker, Robert Chun
OBJECTIVES: The aims of this project were two-fold: 1) To assess pediatric primary care (PCP), pediatric otolaryngology (ENT) and pediatric urgent care (UC) providers' perception of their adherence to the 2013 American Academy of Pediatrics (AAP) established guidelines for the diagnosis and management of acute bacterial rhinosinusitis (ABRS) in children 1-18 years old and 2) to assess the same providers' practice patterns in the diagnosis and management of pediatric chronic rhinosinusitis (PCRS)...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29570533/subunit-reconstruction-of-mid-facial-defects-with-free-style-facial-perforator-flaps
#19
Utku Can Dölen, Yahya Baltu, Orhan Aydin
INTRODUCTION: Reconstruction of facial defects is not only important for cosmesis but also for the function. Local flaps are considered the best reconstruction method for facial defects. The authors want to show the feasibility of free style facial perforator flap for the reconstruction of moderate sized mid-facial defects. METHODS: Free style facial artery and lateral nasal artery perforator flaps were performed in 22 patients (11 males and 11 females) who had removal of facial tumor between March 2015 and December 2016 RESULTS:: The median age of patients was 62 years (range: 35-84)...
March 22, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29568342/smoking-environmental-tobacco-smoke-and-occupational-irritants-increase-the-risk-of-chronic-rhinitis
#20
Hanna Hisinger-Mölkänen, Päivi Piirilä, Tari Haahtela, Anssi Sovijärvi, Paula Pallasaho
Background: Allergic and non-allergic rhinitis cause a lot of symptoms in everyday life. To decrease the burden more information of the preventable risk factors is needed. We assessed prevalence and risk factors for chronic nasal symptoms, exploring the effects of smoking, environmental tobacco smoke, exposure to occupational irritants, and their combinations. Methods: In 2016, a postal survey was conducted among a random population sample of 8000 adults in Helsinki, Finland with a 50...
2018: World Allergy Organization Journal
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