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https://www.readbyqxmd.com/read/29929175/kyphoplasty-with-purified-silicone-vk100-elastoplasty-to-treat-spinal-lytic-lesions-in-cancer-patients-a-retrospective-evaluation-of-41-cases
#1
Stefano Telera, Alfredo Pompili, Francesco Crispo, Maddalena Giovannetti, Andrea Pace, Veronica Villani, Alessandra Fabi, Isabella Sperduti, Laura Raus
OBJECTIVES: Balloon Kyphoplasty (BKP) for vertebral compression fractures (VCFs) in cancer patients is more challenging than for osteoporotic ones. Cord compressions are frequent and the incidence of complications ten-fold greater. Polymethylmetacrylate (PMMA) is the gold standard material for BKP but has disadvantages: exothermic reaction, short working time, rapid solidification, absence of osteoconduction. VK100 is a mixture of Dimethyl Methylvinyl siloxane and Barium Sulphate. It is elastic, adhesive to bone, leaves 30 min before solidification without exothermic reaction, and shows a stiffness close to the intact vertebrae...
June 15, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29928706/variability-of-clinical-target-volume-delineation-for-rectal-cancer-patients-planned-for-neoadjuvant-radiotherapy-with-the-aid-of-the-platform-anatom-e
#2
Pierfrancesco Franco, Francesca Arcadipane, Elisabetta Trino, Elena Gallio, Stefania Martini, Giuseppe Carlo Iorio, Cristina Piva, Francesco Moretto, Maria Grazia Ruo Redda, Roberta Verna, Vassiliki Tseroni, Cristina Bona, Gabriele Pozzi, Christian Fiandra, Riccardo Ragona, Oscar Bertetto, Umberto Ricardi
Objective: Delineation of treatment volumes is a major source of uncertainties in radiotherapy (RT). This is also true for rectal cancer patients undergoing neoadjuvant RT, with a potential impact on treatment quality. We investigated the role of the digital platform Anatom-e (Anatom-e Information Sytems Ltd., Houston, Texas) in increasing the compliance to follow a specific treatment protocol in a multicentric setting. Materials and methods: Two clinical cases of locally advanced rectal cancer were chosen...
June 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29928685/improving-quality-of-care-and-timely-access-to-radiation-therapy-for-patients-with-invasive-cervical-cancer-at-the-national-cancer-institute-paraguay
#3
REVIEW
Geraldine Jacobson, Linus Chuang, Maximilian Pankow
The purpose of this report is to describe the interventions implemented between 2012 and 2017 at the National Cancer Institute Paraguay (NCI Paraguay) to improve treatment quality and efficiency for patients with cervical cancer, with an emphasis on radiation quality and access. The NCI Paraguay requested collaboration with Health Volunteers Overseas (HVO), an international volunteer organization, to improve the care of patients with cervical cancer. This report is based on site visits to NCI Paraguay by HVO volunteers in 2012, 2013, and 2016, with a follow-up report from the site in 2017...
August 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29928493/aptamers-novelty-tools-for-cancer-biology
#4
REVIEW
Ricardo L Pereira, Isis C Nascimento, Ana P Santos, Isabella E Y Ogusuku, Claudiana Lameu, Günter Mayer, Henning Ulrich
Although the term 'cancer' was still over two thousand years away of being coined, the first known cases of the disease date back to about 3000BC, in ancient Egypt. Five thousand years later, still lacking a cure, it has become one of the leading causes of death, killing over half a dozen million people yearly. So far, monoclonal antibodies are the most successful immune-therapy tools when it comes to fighting cancer. The number of clinical trials that use them has been increasing steadily during the past few years, especially since the Food and Drug Administration greenlit the use of the first immune-checkpoint blockade antibodies...
June 1, 2018: Oncotarget
https://www.readbyqxmd.com/read/29928476/cd73-expression-and-clinical-significance-in-human-metastatic-melanoma
#5
Inês Monteiro, Selena Vigano, Mohamed Faouzi, Isabelle Treilleux, Olivier Michielin, Christine Ménétrier-Caux, Christophe Caux, Pedro Romero, Laurence de Leval
Background: CD73 is an ectoenzyme involved in the production of adenosine. It exerts immunosuppressive and protumoral roles and has emerged as a potential immuno-oncology target. Results: CD73 expression was detected in TC in 54% of melanoma metastases, involving < 50% TC in the majority of the cases, with variable intensity. CD73 expression was significantly associated with a lower Breslow's depth of the primary lesion and was more frequent in patients having received prior non-surgical therapies...
June 1, 2018: Oncotarget
https://www.readbyqxmd.com/read/29928439/ovarian-cancer-initially-presenting-with-supra-clavicular-lymph-node-metastasis-a-case-report
#6
Lu Hong, Hui Qiu, Zijie Mei, Hui Zhang, Shaopin Liu, Hong Cao
Supra-clavicular lymph node metastasis from ovarian cancer is rare. The present study reports the unique case of a 43-years-old patient who initially presented with left supra-clavicular lymph node metastasis, and was nulliparous. According to fine-needle aspiration cytology of the metastatic left supra-clavicular lymph nodes and 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) scan, the patient was diagnosed with poorly differentiated serous carcinoma of ovarian cancer, stage IV...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928416/a-novel-n-staging-system-for-npc-based-on-imrt-and-rtog-guidelines-for-lymph-node-levels-results-of-a-prospective-multicentric-clinical-study
#7
Min Kang, Pingting Zhou, Tingting Wei, Tingting Zhao, Jianxiong Long, Guisheng Li, Haolin Yan, Guosheng Feng, Meilian Liu, Jinxian Zhu, Rensheng Wang
The present study aimed to investigate the cervical lymph node metastasis of nasopharyngeal carcinoma (NPC) and to establish a novel N staging standard for NPC, based on intensity modulated radiation therapy (IMRT) via a prospective multicenter clinical trial. Between January 2006 and December 2009, a total of 492 patients with NPC without distant metastasis were included in the present study. All patients were treated with IMRT. According to Radiation Therapy Oncology Group division standards, the present study proposed a novel N staging system following the review of magnetic resonance images in comparison with the 7th edition of Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) staging system...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928208/complete-response-for-more-than-4-years-following-neoadjuvant-folfox-and-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-for-a-patient-with-advanced-gastric-cancer-with-extensive-peritoneal-carcinomatosis
#8
Renata D'Alpino Peixoto, Tercia Tarciane de Sousa, Pedro Alexandre Ismael Amaral Silva, Luciana Rodrigues de Meirelles, Carlos Henrique Andrade Teixeira
Background: Peritoneal carcinomatosis is usually a terminal disease with short median survival in patients with gastric cancer. Systemic FOLFOX is one of the most used regimens in the first-line treatment of metastatic gastric cancer. However, there is scarce evidence that cytoreductive surgery (CRS) and intraperitoneal heated chemotherapy (HIPEC) improves oncological outcomes of patients with advanced gastric cancer. Methods: Herein we present a case of a young woman with advanced gastric cancer with omental and peritoneal metastases who achieved an excellent response after 6 months of FOLFOX followed by CRS and HIPEC...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29927915/faster-cancer-treatment-pathway-in-gynaecological-malignancy-a-repeat-clinical-audit
#9
Minah Ha, Anand Gangji
AIMS: This clinical audit aimed to review the Faster Cancer Tract pathway in Northland patients with gynaecological cancers to evaluate whether there has been an improvement since the previous audit in 2014-2015. METHODS: There were 46 patients who were discussed at the gynaecological oncology multidisciplinary meeting between January 2016 and December 2016 with confirmed gynaecological malignancy. Information regarding the time taken for various investigations, referrals, decisions and treatment to be completed for each patient was obtained from clinical records and compared against the Ministry of Health faster cancer treatment targets, standards of service provision and data from the previous audit...
June 22, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29927668/blood-based-analyses-of-cancer-circulating-myeloid-derived-suppressor-cells-is-a-new-era-coming
#10
Karolina Okla, Iwona Wertel, Anna Wawruszak, Marcin Bobiński, Jan Kotarski
Progress in cancer treatment made by the beginning of the 21st century has shifted the paradigm from one-size-fits-all to tailor-made treatment. The popular vision, to study solid tumors through the relatively noninvasive sampling of blood, is one of the most thrilling and rapidly advancing fields in global cancer diagnostics. From this perspective, immune-cell analysis in cancer could play a pivotal role in oncology practice. This approach is driven both by rapid technological developments, including the analysis of circulating myeloid-derived suppressor cells (cMDSCs), and by the increasing application of (immune) therapies, the success or failure of which may depend on effective and timely measurements of relevant biomarkers...
June 21, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29927521/what-has-come-out-from-phytomedicines-and-herbal-edibles-for-the-treatment-of-cancer
#11
Srinivasa Reddy Bonam, Seng Wu Yuan, Lakshmi Tunki, Ranjithkumar Chellian, Sampath Kumar Halmuthur M, Sylviane Muller, Vijayapandi Pandy
Several modern treatment strategies have been adopted to combat cancer with the aim of minimizing toxicity. Medicinal plant-based compounds with the potential to treat cancer have been widely studied in preclinical research and have elicited many innovative ways of leading-edge clinical research. In parallel, researchers have eagerly tried to reduce the toxicity of current chemotherapeutic agents either by combining them with herbals or in using herbals alone. The focus of this article is to present an update of medicinal plants and their bioactive compounds, or mere changes in the bioactive compounds, and herbal edibles, which display efficacy against diverse cancer cells and in anticancer therapy...
June 21, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29926551/factors-that-predict-clinical-benefit-of-egfr-tki-therapy-in-patients-with-egfr-wild-type-lung-adenocarcinoma
#12
Seo Yun Kim, Jae Kyung Myung, Hye Ryoun Kim, Im Il Na, Jae Soo Koh, Hee Jong Baek, Cheol Hyeon Kim
BACKGROUND: Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancers have emerged as key predictive biomarkers in EGFR tyrosine kinase inhibitor (TKI) treatment. However, a few patients with wild-type EGFR also respond to EGFR TKIs. This study investigated the factors predicting successful EGFR TKI treatment in lung adenocarcinoma patients with wild-type EGFR. METHODS: We examined 66 patients diagnosed with lung adenocarcinoma carrying wide-type EGFR who were treated with EGFR TKIs...
June 19, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29926160/the-clinical-usefulness-of-optical-coherence-tomography-during-cancer-interventions
#13
REVIEW
Labrinus van Manen, Jouke Dijkstra, Claude Boccara, Emilie Benoit, Alexander L Vahrmeijer, Michalina J Gora, J Sven D Mieog
INTRODUCTION: Tumor detection and visualization plays a key role in the clinical workflow of a patient with suspected cancer, both in the diagnosis and treatment. Several optical imaging techniques have been evaluated for guidance during oncological interventions. Optical coherence tomography (OCT) is a technique which has been widely evaluated during the past decades. This review aims to determine the clinical usefulness of OCT during cancer interventions focussing on qualitative features, quantitative features and the diagnostic value of OCT...
June 20, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29926104/the-value-of-clinical-colorectal-cancer-registries-in-colorectal-cancer-research-a-systematic-review
#14
Caroline MacCallum, Anita Skandarajah, Peter Gibbs, Ian Hayes
Importance: Clinical colorectal cancer registries (CCCRs) are potentially powerful tools in colorectal cancer research. They are resource intensive, but to our knowledge, no formal review of their value exists. While quality control, clinical audit, and benchmarking are important factors in assessing the value of maintaining CCCRs, they are difficult to quantify. This study focuses on registry research output as a measure of value; the study hypothesizes that CCCRs do not produce sufficient published research output of clinical significance to justify the resources required to maintain them...
June 20, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29925527/identification-of-fda-approved-oncology-drugs-with-selective-potency-in-high-risk-childhood-ependymoma
#15
Andrew M Donson, Vladimir Amani, Elliot A Warner, Andrea M Griesinger, Davis A Witt, Jean M Mulcahy Levy, Lindsey M Hoffman, Todd C Hankinson, Michael H Handler, Rajeev Vibhakar, Kathleen Dorris, Nicholas K Foreman
Children with ependymoma are cured in less than 50% of cases, with little improvement in outcome over the last several decades. Chemotherapy has not impacted survival in ependymoma, due in part to a lack of preclinical models that has precluded comprehensive drug testing. We recently developed two human ependymoma cell lines harboring high-risk phenotypes which provided us with an opportunity to execute translational studies. ependymoma and other pediatric brain tumor cell lines were subject to a large-scale comparative drug screen of ependymoma -approved oncology drugs for rapid clinical application...
June 20, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29925063/targeting-shp-1-2-and-ship-pathways-a-novel-strategy-for-cancer-treatment
#16
REVIEW
Wolfram C M Dempke, Peter Uciechowski, Klaus Fenchel, Timothy Chevassut
Well-balanced levels of tyrosine phosphorylation, maintained by the reversible and coordinated actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), are critical for a wide range of cellular processes including growth, differentiation, metabolism, migration, and survival. Aberrant tyrosine phosphorylation, as a result of a perturbed balance between the activities of PTKs and PTPs, is linked to the pathogenesis of numerous human diseases, including cancer, suggesting that PTPs may be innovative molecular targets for cancer treatment...
June 20, 2018: Oncology
https://www.readbyqxmd.com/read/29924704/effects-of-surgery-with-salvage-stereotactic-radiosurgery-versus-surgery-with-whole-brain-radiation-therapy-in-patients-with-one-to-four-brain-metastases-jcog0504-a-phase-iii-noninferiority-randomized-controlled-trial
#17
Takamasa Kayama, Shinya Sato, Kaori Sakurada, Junki Mizusawa, Ryo Nishikawa, Yoshitaka Narita, Minako Sumi, Yasuji Miyakita, Toshihiro Kumabe, Yukihiko Sonoda, Yoshiki Arakawa, Susumu Miyamoto, Takaaki Beppu, Kazuhiko Sugiyama, Hirohiko Nakamura, Motoo Nagane, Yoko Nakasu, Naoya Hashimoto, Mizuhiko Terasaki, Akira Matsumura, Eiichi Ishikawa, Toshihiko Wakabayashi, Yasuo Iwadate, Shiro Ohue, Hiroyuki Kobayashi, Manabu Kinoshita, Kenichiro Asano, Akitake Mukasa, Katsuyuki Tanaka, Akio Asai, Hideo Nakamura, Tatsuya Abe, Yoshihiro Muragaki, Koichi Iwasaki, Tomokazu Aoki, Takao Watanabe, Hikaru Sasaki, Shuichi Izumoto, Masahiro Mizoguchi, Takayuki Matsuo, Hideo Takeshima, Motohiro Hayashi, Hidefumi Jokura, Takashi Mizowaki, Eiji Shimizu, Hiroki Shirato, Masao Tago, Hiroshi Katayama, Haruhiko Fukuda, Soichiro Shibui
Purpose Whereas whole-brain radiotherapy (WBRT) has been the standard treatment of brain metastases (BMs), stereotactic radiosurgery (SRS) is increasingly preferred to avoid cognitive dysfunction; however, it has not been clearly determined whether treatment with SRS is as effective as that with WBRT or WBRT plus SRS. We thus assessed the noninferiority of salvage SRS to WBRT in patients with BMs. Patients and Methods Patients age 20 to 79 years old with performance status scores of 0 to 2-and 3 if caused only by neurologic deficits-and with four or fewer surgically resected BMs with only one lesion > 3 cm in diameter were eligible...
June 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29924296/esmo-consensus-conference-on-malignant-lymphoma-management-of-ultra-high-risk-patients
#18
M Hutchings, M Ladetto, C Buske, P de Nully Brown, A J M Ferreri, M Pfreundschuh, N Schmitz, A Sureda Balari, G van Imhoff, J Walewski
The European Society for Medical Oncology (ESMO) consensus conference on malignant lymphoma was held on 20 June 2015 in Lugano, Switzerland, and included a multidisciplinary panel of 25 leading experts. The aim of the conference was to develop recommendations on critical subjects difficult to consider in detail in the ESMO Clinical Practice Guidelines. The following areas were identified: (1) the elderly patient, (2) prognostic factors suitable for clinical use and (3) the 'ultra-high-risk' group. Before the conference, the expert panel was divided into three working groups; each group focused on one of these areas in order to address clinically relevant questions relating to that topic...
June 19, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29923622/advances-in-the-computational-and-molecular-understanding-of-the-prostate-cancer-cell-nucleus
#19
Neil M Carleton, George Lee, Anant Madabhushi, Robert W Veltri
Nuclear alterations are a hallmark of many types of cancers, including prostate cancer (PCa). Recent evidence shows that subvisual changes, ones that may not be visually perceptible to a pathologist, to the nucleus and its ultrastructural components can precede visual histopathological recognition of cancer. Alterations to nuclear features, such as nuclear size and shape, texture, and spatial architecture, reflect the complex molecular-level changes that occur during oncogenesis. Quantitative nuclear morphometry, a field that uses computational approaches to identify and quantify malignancy-induced nuclear changes, can enable a detailed and objective analysis of the PCa cell nucleus...
June 20, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29923615/clinical-development-and-initial-approval-of-novel-immune-checkpoint-inhibitors-in-oncology-insights-from-a-global-regulatory-perspective
#20
REVIEW
Philippe Serrano, Markus Hartmann, Elmar Schmitt, Pedro Franco, Georgios Amexis, Jan Gross, Christine Mayer-Nicolai
No abstract text is available yet for this article.
June 20, 2018: Clinical Pharmacology and Therapeutics
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