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https://www.readbyqxmd.com/read/28437274/axial-length-and-anterior-segment-alterations-in-former-preterm-infants-and-full-term-neonates-analyzed-with-scheimpflug-imaging
#1
Achim Fieß, Ruth Kölb-Keerl, Markus Knuf, Bernd Kirchhof, Christiane Blecha, Isabel Oberacher-Velten, Philipp S Muether, Jacqueline Bauer
PURPOSE: To compare the axial length and anterior segment alterations in preterm infants with and without retinopathy of prematurity with those of full-term infants. METHODS: The Wiesbaden Prematurity Study investigated 503 participants of former gestational age ≤32 weeks and gestational age ≥37 weeks now being aged 4 to 10 years. This study included 485 participants in the prospective controlled cross-sectional, hospital-based study with successful Pentacam Scheimpflug imaging...
April 21, 2017: Cornea
https://www.readbyqxmd.com/read/28437216/posttraumatic-symptom-reporting-and-reported-cigarette-smoking-during-pregnancy
#2
Sara L Kornfield, Marian Moseley, Dina Appleby, Courtney L McMickens, Mary D Sammel, C Neill Epperson
INTRODUCTION: Increased prevalence of nicotine dependence among individuals suffering from posttraumatic stress disorder (PTSD) is well established. However, there are limited studies on the prevalence of smoking during pregnancy in relation to prepregnancy history of trauma exposures and active PTSD symptoms during pregnancy. Prenatal smoking has been implicated in a host of negative outcomes for mother and baby. Given maternal and fetal risk, it is critical to define predictors of continued cigarette smoking during pregnancy...
February 21, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28437004/4-4-dichlorodiphenyltrichloroethane-ddt-and-4-4-dichlorodiphenyldichloroethylene-dde-inhibit-myogenesis-in-c2c12-myoblasts
#3
Jonggun Kim, Min Young Park, Yoo Kim, Kyong Sup Yoon, John Marshall Clark, Yeonhwa Park, Kwang-Youn Whang
BACKGROUND: Most countries have banned the use of 4,4'-Dichlorodiphenyltrichloroethane (DDT). However, due to its extremely high lipophilic characteristics, DDT and its metabolite 4,4'-dichlorodiphenyldichloroethylene (DDE) are ubiquitous in the environment and in many types of food. The positive correlation between exposure to insecticides, including DDT and DDE, and weight gain, resulting in impaired energy metabolism in offspring following perinatal DDT and DDE exposure was previously reported...
April 24, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28436167/placental-histopathology-associated-with-preeclampsia-a-systematic-review-and-meta-analysis
#4
REVIEW
Maria Letizia Falco, Janani Sivanathan, Arianna Laoreti, Basky Thilaganathan, Asma Khalil
OBJECTIVES: Preeclampsia is associated with impaired trophoblast invasion and typical villous and vascular placental lesions. The primary aim was to conduct a systematic review in order to quantify the prevalence of placental histopathological lesions in pregnancies complicated by preeclampsia. METHODS: MEDLINE, EMBASE and CINAHL were searched electronically and relevant articles reporting placental histopathological lesions were assessed according to the following criteria: study design, number of pregnancies, type of preeclampsia and whether the pathologist was blinded to the clinical information...
April 23, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28436166/perinatal-loss-at-term-the-role-of-uteroplacental-and-fetal-doppler-assessment
#5
Caitriona Monaghan, Julia Binder, Baskaran Thilaganathan, José Morales-Roselló, Asma Khalil
OBJECTIVE: To examine the association of uterine artery (UtA) Doppler indices and cerebroplacental ratio (CPR) on perinatal outcome at term. METHODS: This retrospective cohort study conducted in a single tertiary referral centre included all singleton pregnancies undergoing ultrasound assessment in the third trimester, which subsequently delivered at term. Fetal biometry and Dopplers including the umbilical artery (UA), middle cerebral artery (MCA) and uterine artery were recorded...
April 24, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28435137/group-b-streptococcus-and-perinatal-mortality
#6
Piet Cools, Pierrette Melin
The World Health Organization estimates that every year, one million neonatal deaths occur because of neonatal infection. Furthermore, an equal number of stillbirths are thought to be caused by infections. Here we discuss the role of Streptococcus agalactiae (group B Streptococcus, GBS) in neonatal disease and stillbirth.
April 20, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28435017/association-of-paraoxonase-1-and-oxidative-stress-with-acute-kidney-injury-in-premature-asphyxiated-neonates
#7
Jasmina Ivanišević, Jelena Kotur-Stevuljević, Aleksandra Stefanović, Milica Miljković, Zorana Jelić-Ivanović, Biljana Pejović, Amira Peco-Antić
OBJECTIVES: Acute kidney injury (AKI) is defined as decrease in glomerular filtration rate with increase in serum creatinine (sCr). Perinatal asphyxia (PNA) may be an ethiological factor for AKI with oxidative stress also implicated. Paraoxonase 1 (PON1) has been reported to be decreased in renal diseases. The aim of our study was to evaluate paraoxonase 1 (PON1) and oxidative stress status, their change during the first hours and days of life and the ability of these parameters to discriminate neonates having AKI from those who do not have it...
April 20, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28434652/multifetal-reduction-of-triplets-to-twins-compared-with-non-reduced-twins-a-meta-analysis
#8
Yaniv Zipori, Jigal Haas, Howard Berger, Eran Barzilay
The current systematic review and meta-analysis evaluates the perinatal outcomes in twin pregnancies following multifetal pregnancy reduction (MPR) compared with non-reduced twins. We considered all studies comparing perinatal outcomes of twin pregnancies following MPR to non-reduced twin pregnancies. Our search yielded 639 publications, of which 91 were assessed for eligibility. A total of 22 studies met our inclusion criteria. Overall, fetal reduction of triplets to twins resulted in comparable perinatal outcomes to non-reduced twins with regards to gestational age and birthweight at delivery, pregnancy loss prior to 24 weeks, as well as the development of gestational diabetes and hypertensive disorders of pregnancy...
April 10, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28434210/changes-in-perinatal-hospital-deaths-occurring-outside-the-neonatal-intensive-care-unit-over-a-decade
#9
Amélie Du Pont-Thibodeau, Keith Barrington, Catherine Taillefer, Annie Janvier
AIM: Perinatal deaths occurring outside the neonatal intensive care unit (NICU) are rarely recorded in outcome studies, despite having a direct impact on perinatal statistics. Our aim was to investigate the timing and modes of perinatal deaths that occurred outside the NICU and changes over time. METHOD: We reviewed all perinatal deaths from 22 weeks of gestation onwards, without NICU admissions, during two periods in a Canadian tertiary mother and baby hospital and categorised deaths according to nine specific categories...
April 23, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28434005/chorioamniotic-membrane-separation-after-fetoscopic-laser-photocoagulation
#10
Mayumi Takano, Masahiko Nakata, Susumu Murata, Masahiro Sumie, Mineto Morita
INTRODUCTION: This study aimed to investigate the risk factors, incidence, and influence on the perinatal outcome of chorioamniotic membrane separation (CMS) after fetoscopic laser photocoagulation (FLP). MATERIAL AND METHODS: This retrospective study included 312 women who underwent FLP for twin-to-twin transfusion syndrome (TTTS). Clinical records were used to review obstetrical examinations, complications, operative data, ultrasonographic findings, and perinatal and neonatal follow-up data in all patients...
April 22, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28433501/disrupted-in-schizophrenia-1-regulates-the-processing-of-reelin-in-the-perinatal-cortex
#11
Nicholas J Bradshaw, Svenja V Trossbach, Sabrina Köber, Susanne Walter, Ingrid Prikulis, Sascha Weggen, Carsten Korth
Disrupted in Schizophrenia 1 (DISC1) is a prominent gene in mental illness research, encoding a scaffold protein known to be of importance in the developing cerebral cortex. Reelin is a critical extracellular protein for development and lamination of the prenatal cortex and which has also been independently implicated in mental illness. Regulation of reelin activity occurs through processing by the metalloproteinases ADAMTS-4 and ADAMTS-5. Through cross-breeding of heterozygous transgenic DISC1 mice with heterozygous reeler mice, which have reduced reelin, pups heterozygous for both phenotypes were generated...
April 19, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28432735/perinatal-outcomes-among-young-indigenous-australian-mothers-a-cross-sectional-study-and-comparison-with-adult-indigenous-mothers
#12
Malinda Steenkamp, Jacqueline Boyle, Sue Kildea, Vivienne Moore, Michael Davies, Alice Rumbold
BACKGROUND: The teenage pregnancy rate is high among Indigenous Australian women, yet little is known about their pregnancy outcomes. Moreover, against a background of extreme social disadvantage, the relative importance of age as a risk factor for adverse outcomes among Indigenous pregnancies is unclear. We compared perinatal outcomes for Indigenous teenagers (<20 years) with adult Indigenous women (20-34 years), and described outcomes in subgroups of teenagers. METHODS: Data were analyzed for 2421 singleton births to Indigenous women aged <35 years in Australia's Northern Territory from 2003 to 2005...
April 22, 2017: Birth
https://www.readbyqxmd.com/read/28432664/human-perinatal-immunity-in-physiological-conditions-and-during-infection
#13
REVIEW
Gijs T J van Well, Leonie A Daalderop, Tim Wolfs, Boris W Kramer
The intrauterine environment was long considered sterile. However, several infectious threats are already present during fetal life. This review focuses on the postnatal immunological consequences of prenatal exposure to microorganisms and related inflammatory stimuli. Both the innate and adaptive immune systems of the fetus and neonate are immature, which makes them highly susceptible to infections. There is good evidence that prenatal infections are a primary cause of preterm births. Additionally, the association between antenatal inflammation and adverse neonatal outcomes has been well established...
December 2017: Molecular and Cellular Pediatrics
https://www.readbyqxmd.com/read/28432293/quiescence-of-adult-oligodendrocyte-precursor-cells-requires%C3%A2-thyroid-hormone-and-hypoxia-to-activate-runx1
#14
Yasuhito Tokumoto, Shinpei Tamaki, Yasuaki Kabe, Keiyo Takubo, Makoto Suematsu
The adult mammalian central nervous system (CNS) contains a population of slowly dividing oligodendrocyte precursor cells (OPCs), i.e., adult OPCs, which supply new oligodendrocytes throughout the life of animal. While adult OPCs develop from rapidly dividing perinatal OPCs, the mechanisms underlying their quiescence remain unknown. Here, we show that perinatal rodent OPCs cultured with thyroid hormone (TH) under hypoxia become quiescent and acquire adult OPCs-like characteristics. The cyclin-dependent kinase inhibitor p15/INK4b plays crucial roles in the TH-dependent cell cycle deceleration in OPCs under hypoxia...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431988/time-trends-in-births-and-cesarean-deliveries-among-women-with-disabilities
#15
Willi Horner-Johnson, Frances M Biel, Blair G Darney, Aaron B Caughey
BACKGROUND: Although it is likely that childbearing among women with disabilities is increasing, no empirical data have been published on changes over time in the numbers of women with disabilities giving birth. Further, while it is known that women with disabilities are at increased risk of cesarean delivery, temporal trends in cesarean deliveries among women with disabilities have not been examined. OBJECTIVE: To assess time trends in births by any mode and in primary cesarean deliveries among women with physical, sensory, or intellectual/developmental disabilities...
April 6, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28431858/third-trimester-preterm-and-term-premature-rupture-of-membranes-is-there-any-difference-in-maternal-characteristics-and-pregnancy-outcomes
#16
Ivana Chandra, Lizhou Sun
BACKGROUND: The clinical significance and management of preterm premature rupture of membranes (PPROM) remains a topic of a controversy. Although PROM is associated with a low rate of complications, PPROM may lead to significant neonatal and maternal morbidity. METHODS: We performed a retrospective study of 714 women who presented to Jiangsu Province Hospital with third trimester PPROM or PROM between January and December 2015. The data were analyzed by SPSS; the significance of maternal characteristics, and maternal and neonatal outcomes were tested using Student's t test and the χ(2) test...
April 18, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28431617/short-term-outcome-of-functional-integrity-of-the-auditory-brainstem-in-term-infants-who-suffer-perinatal-asphyxia
#17
Ze D Jiang, Cao Chen
OBJECTIVES: To assess short-term outcome of impaired functional integrity of the auditory brainstem in term infants who suffer perinatal asphyxia. METHODS: Maximum length sequence brainstem auditory evoked response (MLS BAER) was recorded and analyzed at a mean age of 3months in term infants after perinatal asphyxia. The data were compared with age-matched normal term infants. RESULTS: The infants after asphyxia showed an increase in the latency of MLS BAER wave III at 91, 455 and 910/s, and wave V at all click rates of 91-910/s...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28431549/household-food-insecurity-is-associated-with-abdominal-but-not-general-obesity-among-iranian-children
#18
Fateme Jafari, Simin Ehsani, Azadeh Nadjarzadeh, Ahmad Esmaillzadeh, Mahmood Noori-Shadkam, Amin Salehi-Abargouei
BACKGROUND: Childhood obesity is increasing all over the world. Food insecurity is mentioned as a possible risk factor; however, previous studies have led to inconsistent results in different societies while data are lacking for the Middle East. We aimed to investigate the relationship between food insecurity and general or abdominal obesity in Iranian children in a cross-sectional study. METHODS: Anthropometric data including height, weight, and waist circumference were measured by trained nutritionists...
April 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28431382/childhood-maltreatment-preceding-depressive-disorder-at-age-18-years-a-prospective-brazilian-birth-cohort-study
#19
Erika Alejandra Giraldo Gallo, Christian Loret De Mola, Fernando Wehrmeister, Helen Gonçalves, Christian Kieling, Joseph Murray
BACKGROUND: Childhood maltreatment is linked with increased risk for mental illness in adolescence and adulthood. However, little evidence is available on whether different forms of maltreatment have specific effects, and no prospective studies in low- or middle-income countries have addressed this issue. METHODS: Participants in a population-based, birth cohort study in Pelotas, Brazil (N=3715) self-reported exposure to maltreatment (emotional abuse, physical neglect, physical abuse, sexual abuse, domestic violence) in confidential questionnaires at age 15 years, and were assessed for major depression in interviews at age 18 years, using the MINI...
April 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28431127/cytomegalovirus-cmv-kinetics-following-primary-infection-in-healthy-women
#20
Michael S Forman, Dhananjay Vaidya D, Oluwaseyi Bolorunduro, Marie Diener-West, Robert F Pass, Ravit Arav-Boger
The kinetics of CMV DNA in infected asymptomatic hosts are largely unknown. We measured viral load (VL) in 124 fluid samples (oral, urine, vaginal, blood) collected from 21 women who acquired CMV. A quantitative real-time PCR of US17, which correlated with clinical assays, was used. VL decreased following primary infection in all fluids. The geometric mean VL of vaginal fluid was significantly higher than that of other sources: oral (3.89 95% CI [1.43 - 10.57]), urine (6.36 95% CI [2.48 - 16.32]) and whole blood (11...
April 18, 2017: Journal of Infectious Diseases
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