Sophie A Riesmeijer, Ilja M Nolte, Loes M Olde Loohuis, Lianne M Reus, Toni Boltz, Michael Ng, Dominic Furniss, Paul M N Werker, Roel A Ophoff
BACKGROUND: Dupuytren's disease (DD) is a common complex trait, with varying severity and incompletely understood etiology. Genome-wide association studies (GWAS) have identified risk loci. Here, we examine whether genetic risk profiles of DD in patients are associated with clinical variation and disease severity as well as with patient genetic risk profiles of genetically correlated traits, including body mass index (BMI), triglycerides (TG), high-density lipoproteins (HDL), type 2 diabetes mellitus (T2D), and endophenotypes fasting glucose (FG), and glycated hemoglobin (HbA1c)...
May 31, 2023: Plastic and Reconstructive Surgery