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Spinal neuromodulation

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https://www.readbyqxmd.com/read/29763654/obturator-neuromodulation-with-laparoscopic-placement-of-an-obturator-lead-for-the-treatment-of-intractable-opioid-dependent-chronic-pelvic-pain-due-to-obturator-neuralgia
#1
Richard P Marvel
Chronic pelvic pain(CPP) is a common condition in women that can have a devastating effect on quality of life. Some of the most severe forms of CPP are related to peripheral nerve injuries causing persistent neuropathic pain. This is a case of a young woman with severe opioid dependent chronic pelvic and right groin pain due to obturator neuralgia. She had failed a multitude of treatments including multiple medications, manual physical therapy, nerve blocks, surgical neurolysis and spinal cord stimulation without significant benefit...
May 12, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29722312/neuromodulator-interactions-and-spinal-cord-injury-in-lamprey
#2
David Parker, Thomas J McClelland
No abstract text is available yet for this article.
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29713421/failed-back-surgery-syndrome-a-review-article
#3
REVIEW
James R Daniell, Orso L Osti
Postsurgical spine syndrome is becoming an increasingly common challenge for clinicians who deal with spinal disorders owing to the expanding indications for spinal surgery and the aging world population. A multidisciplinary approach is most appropriate for patients who are unlikely to benefit from further formal surgical intervention. Anticonvulsant medications are effective in managing neuropathic pain after surgery, whereas opioids are rarely beneficial. Neuromodulation via a surgically implanted dorsal column neurostimulator is gaining popularity owing to its substantial superiority over conventional medical management and/or further surgical intervention...
April 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/29674264/ultrasonic-modulation-of-neural-circuit-activity
#4
REVIEW
William J Tyler, Shane W Lani, Grace M Hwang
Ultrasound (US) is recognized for its use in medical imaging as a diagnostic tool. As an acoustic energy source, US has become increasingly appreciated over the past decade for its ability to non-invasively modulate cellular activity including neuronal activity. Data obtained from a host of experimental models has shown that low-intensity US can reversibly modulate the physiological activity of neurons in peripheral nerves, spinal cord, and intact brain circuits. Experimental evidence indicates that acoustic pressures exerted by US act, in part, on mechanosensitive ion channels to modulate activity...
April 16, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29649928/noninvasive-activation-of-cervical-spinal-networks-after-severe-paralysis
#5
Parag Gad, Sujin Lee, Nicholas Terrafranca, Hui Zhong, Amanda Turner, Yury Gerasimenko, Victor Reggie Edgerton
Paralysis of the upper extremities following cervical spinal cord injury (SCI) significantly impairs one's ability to live independently. While regaining hand function or grasping ability is considered one of the most desired functions in tetraplegics, limited therapeutic development in this direction has been demonstrated to date in humans with a high, severe cervical injury. The underlying hypothesis is after severe cervical SCI, nonfunctional sensory-motor networks within the cervical spinal cord can be transcutaneously neuromodulated to physiological states which enables and amplifies voluntary control of the hand...
April 13, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29643759/changes-in-h-reflex-recruitment-after-trans-spinal-direct-current-stimulation-with-multiple-electrode-configurations
#6
Alexander Kuck, Dick F Stegeman, Herman van der Kooij, Edwin H F van Asseldonk
Trans-spinal direct current stimulation (tsDCS) is an electro-modulatory tool with possible application in the rehabilitation of spinal cord injury. TsDCS generates a small electric field, aiming to induce lasting, functional neuromodulation in the targeted neuronal networks. Earlier studies have shown significant modulatory effects after application of lumbar tsDCS. However, for clinical application, a better understanding of application specific factors is required. Our goal was to investigate the effect of different electrode configurations using lumbar spinal tsDCS on spinal excitability...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29621012/spinal-cord-neuromodulation-therapy-for-levofloxacin-reinduced-complex-regional-pain-syndrome-and-neurotoxicity-a-case-report
#7
David Hao, Geza Kiss, William Grubb, Shaul Cohen, Danielle Levin, Ashraf Sakr
Fluoroquinolones are a class of popular outpatient antimicrobial agents with a wide spectrum of therapeutic indications for respiratory and genitourinary infections. Though the most common side effects are gastrointestinal, fluoroquinolones have been increasingly associated with neurotoxicity including peripheral neuropathy and seizures. We present here a case of a 43-year-old woman with previously resolved type I complex regional pain syndrome (CRPS) who presented with symptoms of CRPS and neurotoxicity in the setting of levofloxacin administration...
March 31, 2018: A&A practice
https://www.readbyqxmd.com/read/29619317/influence-of-inter-stimulus-interval-of-spinal-cord-stimulation-in-patients-with-disorders-of-consciousness-a-preliminary-functional-near-infrared-spectroscopy-study
#8
Yujin Zhang, Yi Yang, Juanning Si, Xiaoyu Xia, Jianghong He, Tianzi Jiang
Spinal cord stimulation (SCS) is a promising treatment for disorders of consciousness (DOC), but the underlying mechanism and most effective procedures remain uncertain. To optimize the protocol, previous studies evaluated the frequency-specific effects of SCS on neurophysiological activities. However, whether and how the inter-stimulus interval (ISI) parameter affects the SCS neuromodulation in DOC remains unknown. We enrolled nine DOC patients who had implanted SCS devices and conducted three different durations of ISIs...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29608807/long-term-effect-of-peripheral-nerve-field-stimulation-as-add-on-therapy-to-spinal-cord-stimulation-to-treat-low-back-pain-in-failed-back-surgery-syndrome-patients-a-12-month-follow-up-of-a-randomized-controlled-study
#9
Eric-Jan J A A van Gorp, Onno Teernstra, Hans J Aukes, Tanja Hamm-Faber, Katja Bürger, Jan Willem Kallewaard, Geert Spincemaille, Johannes W L C Schapendonk, Leon Vonhögen, Ewald Bronkhorst, Kris C P Vissers
OBJECTIVE: Different approaches in neuromodulation have been used to treat chronic low back pain in failed back surgery syndrome (FBSS) patients. We previously randomized 52 FBSS patients to be treated with spinal cord stimulation (SCS) and additional peripheral nerve field stimulation (PNFS) or SCS alone. At three months, we found a significant reduction of back pain in the PNFS-SCS group compared to the SCS group. In the subsequent open phase part of the study, all patients received optimal SCS and PNFS simultaneously...
April 2, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29608229/prospective-randomized-sham-control-double-blind-crossover-trial-of-subthreshold-spinal-cord-stimulation-at-various-kilohertz-frequencies-in-subjects-suffering-from-failed-back-surgery-syndrome-scs-frequency-study
#10
Adnan Al-Kaisy, Stefano Palmisani, David Pang, Karen Sanderson, Samuel Wesley, Ye Tan, Sheryl McCammon, Andrea Trescott
INTRODUCTION: The increasing use of high frequency paresthesia-free spinal cord stimulation has been associated with improved outcomes in the therapy of neuropathic pain. What is unknown is the effect of varying frequency on pain relief and the placebo effect. MATERIALS AND METHODS: This is a prospective, randomized, sham-controlled double blind crossover study. Subjects with predominantly axial low back pain undergoing spinal cord stimulation therapy for failed back surgery syndrome were randomized to sham, 1200 Hz, 3030 Hz, and 5882 Hz with a four-phase crossover design over 12 weeks...
April 2, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29600889/transcranial-direct-current-stimulation-in-the-modulation-of-neuropathic-pain-a-systematic-review
#11
Mírian Celly Medeiros Miranda David, Alexa Alves de Moraes, Maíra Lopes da Costa, Carlúcia Ithamar Fernandes Franco
Objective To investigate the neuromodulating effect of Transcranial Direct Current Stimulation (tDCS) on Neuropathic Pain (NP). Method A systematic review of articles published in the past five years in MEDLINE, LILACS, Cochrane, Scopus, ScienceDirect, and PEDro. The search was carried out from February to May 2017 using the keywords: neuropathic pain, neuralgia, nerve pain, central pain, peripheral nerve pain, tDCS. The selected studies were full articles written in Portuguese, English, or Spanish with at least one control group, and no less than one pre- or post-intervention variable, with the exclusion of case studies or case series, animal model studies, and studies with combined therapy...
March 30, 2018: Neurological Research
https://www.readbyqxmd.com/read/29593503/emergence-of-serotonergic-neurons-after-spinal-cord-injury-in-turtles
#12
Gabriela Fabbiani, María I Rehermann, Carina Aldecosea, Omar Trujillo-Cenóz, Raúl E Russo
Plasticity of neural circuits takes many forms and plays a fundamental role in regulating behavior to changing demands while maintaining stability. For example, during spinal cord development neurotransmitter identity in neurons is dynamically adjusted in response to changes in the activity of spinal networks. It is reasonable to speculate that this type of plasticity might occur also in mature spinal circuits in response to injury. Because serotonergic signaling has a central role in spinal cord functions, we hypothesized that spinal cord injury (SCI) in the fresh water turtle Trachemys scripta elegans may trigger homeostatic changes in serotonergic innervation...
2018: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29578004/the-triple-monoamine-re-uptake-inhibitor-dov-216-303-promotes-functional-recovery-after-spinal-cord-contusion-injury-in-mice
#13
Tak-Ho Chu, Karen Cummins, Peter K Stys
Serotonin, noradrenaline and dopamine are important neuromodulators for locomotion in the spinal cord. Disruption of descending axons after spinal cord injury resulted in reduction of excitatory and neuromodulatory inputs to spinal neurons for locomotion. Receptor agonists or reuptake inhibitors for these neuromodulators have been shown to be beneficial in incomplete spinal cord injury. In this study, we tested a triple re-uptake inhibitor, DOV 216,303, for its ability to affect motor function recovery after spinal cord injury in mice...
March 22, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29575331/retrospective-case-series-on-the-treatment-of-painful-diabetic-peripheral-neuropathy-with-dorsal-root-ganglion-stimulation
#14
Sam Eldabe, Anthony Espinet, Anders Wahlstedt, Porhan Kang, Liong Liem, Nikunj K Patel, Jan Vesper, Alicia Kimber, William Cusack, Jeffery Kramer
BACKGROUND: The dorsal root ganglion (DRG) has been identified as an important neural structure in the development and maintenance of chronic pain. We present a retrospective case series of patients with refractory painful diabetic peripheral neuropathy (PDPN) that underwent electrical stimulation of the DRG and report on changes in their overall perceived pain and complication rates. METHODS: Ten diabetic males (mean age 65.2 [SD 8.8] years) with painful symptoms of the lower limbs were enrolled and trialed with up to four quadripolar percutaneous DRG stimulation leads between L2 and L5 spinal levels...
March 25, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29568364/efficacy-of-different-spinal-nerve-roots-for-neuromodulation-of-micturition-reflex-in-rats
#15
Jianshu Ni, Xiaohu Wang, Nailong Cao, Jiemin Si, Baojun Gu
Electrical stimulation of peripheral nerves controlling the bladder is an alternative, nondestructive medical treatment for urinary incontinence and retention. In this study, we aimed to identify the most efficient sensory and motor spinal nerve roots involved in the micturition reflex. Unilateral L5-S2 dorsal and ventral roots were electrically stimulated, and bladder reflex contractions were recorded under isovolumetric conditions. Repeated stimulation of the L6 and S1 dorsal roots not only abolished bladder reflex contractions but also induced a poststimulation inhibitory effect, whereas repeated stimulation of the L5 and S2 dorsal roots had no effect...
March 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29565946/anatomy-pathophysiology-and-interventional-therapies-for-chronic-pelvic-pain-a-review
#16
Corey W Hunter, Brad Stovall, Grant Chen, Jonathan Carlson, Robert Levy
BACKGROUND: Chronic pelvic pain (CPP) represents a group of poorly understood disorders that are often refractory to conventional treatment. Referral to pain management typically occurs later in the continuum of care; as such, many of the injections and nerve blocks commonly prescribed for such patients are potentially limited in efficacy. While neuromodulation is conventionally considered the next algorithmic step in the treatment of chronic pain after injections fail, there is a common perception that neuromodulation is largely ineffective for CPP conditions...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29561583/multifunctional-fibers-as-tools-for-neuroscience-and-neuroengineering
#17
Andres Canales, Seongjun Park, Antje Kilias, Polina Anikeeva
Multifunctional devices for modulation and probing of neuronal activity during free behavior facilitate studies of functions and pathologies of the nervous system. Probes composed of stiff materials, such as metals and semiconductors, exhibit elastic and chemical mismatch with the neural tissue, which is hypothesized to contribute to sustained tissue damage and gliosis. Dense glial scars have been found to encapsulate implanted devices, corrode their surfaces, and often yield poor recording quality in long-term experiments...
March 21, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29556028/cortico-reticulo-spinal-circuit-reorganization-enables-functional-recovery-after-severe-spinal-cord-contusion
#18
Leonie Asboth, Lucia Friedli, Janine Beauparlant, Cristina Martinez-Gonzalez, Selin Anil, Elodie Rey, Laetitia Baud, Galyna Pidpruzhnykova, Mark A Anderson, Polina Shkorbatova, Laura Batti, Stephane Pagès, Julie Kreider, Bernard L Schneider, Quentin Barraud, Gregoire Courtine
Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished all motor cortex projections below injury. However, the motor cortex immediately regained adaptive control over the paralyzed legs during electrochemical neuromodulation of lumbar circuits. Glutamatergic reticulospinal neurons with residual projections below the injury relayed the cortical command downstream...
April 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29548962/the-50-most-cited-articles-in-invasive-neuromodulation
#19
Max Ward, Joseph Doran, Boris Paskhover, Antonios Mammis
OBJECTIVES: Bibliometric analysis is a commonly used analytic tool for objective determination of the most influential and peer-recognized articles within a given field. This study is the first bibliometric analysis of the literature in the field of invasive neuromodulation, excluding deep brain stimulation. The objectives of this study are to identify the 50 most cited articles in invasive neuromodulation, provide an overview of the literature to assist in clinical education, and evaluate the effect of impact factor on manuscript recognition...
March 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29533186/closed-loop-neuromodulation-restores-network-connectivity-and-motor-control-after-spinal-cord-injury
#20
Patrick D Ganzer, Michael J Darrow, Eric C Meyers, Bleyda R Solorzano, Andrea D Ruiz, Nicole M Robertson, Katherine S Adcock, Justin T James, Han S Jeong, April M Becker, Mark P Goldberg, David T Pruitt, Seth A Hays, Michael P Kilgard, Robert L Rennaker
Recovery from serious neurological injury requires substantial rewiring of neural circuits. Precisely-timed electrical stimulation could be used to restore corrective feedback mechanisms and promote adaptive plasticity after neurological insult, such as spinal cord injury (SCI) or stroke. This study provides the first evidence that closed-loop vagus nerve stimulation (CLV) based on the synaptic eligibility trace leads to dramatic recovery from the most common forms of SCI. The addition of CLV to rehabilitation promoted substantially more recovery of forelimb function compared to rehabilitation alone following chronic unilateral or bilateral cervical SCI in a rat model...
March 13, 2018: ELife
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