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Spinal modulation

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https://www.readbyqxmd.com/read/29687839/mir-137-attenuates-spinal-cord-injury-by-modulating-neurod4-through-reducing-inflammation-and-oxidative-stress
#1
J Dai, L-J Xu, G-D Han, H-L Sun, G-T Zhu, H-T Jiang, G-Y Yu, X-M Tang
OBJECTIVE: To explore the role of microRNA (miR) 137 in spinal cord injury and its mechanism. MATERIALS AND METHODS: The model of spinal cord injury in mice was established to detect the recovery differences of grip strength in upper and lower limbs of mice. The expressions of miR-137 and neuronal differentiation 4 (NEUROD4) were detected at the same time. The inflammation level and the oxidative stress response after spinal cord injury were subsequently detected after overexpression of miR-137...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29687146/genistein-modulates-the-expression-of-toll-like-receptors-in-experimental-autoimmune-encephalomyelitis
#2
Alyria Teixeira Dias, Sandra Bertelli Ribeiro de Castro, Caio César de Souza Alves, Marcilene Gomes Evangelista, Luan Cristian da Silva, Daniele Ribeiro de Lima Reis, Marco Antonio Machado, Maria Aparecida Juliano, Ana Paula Ferreira
OBJECTIVE AND DESIGN: The present work investigates the modulation of experimental autoimmune encephalomyelitis (EAE) using genistein before the EAE induction. MATERIAL: Female C57BL/6 mice (n = 96 mice/experiment), 4-6 weeks old, were used to induce the EAE. The mice were divided into three experimental groups: non-immunized group, immunized group (EAE), and immunized and treated with genistein group (Genistein). TREATMENT: Genistein was used at a dose of 200 mg/kg s...
April 23, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29686823/two-years-of-functional-electrical-stimulation-by-large-surface-electrodes-for-denervated-muscles-improve-skin-epidermis-in-sci
#3
Giovanna Albertin, Helmut Kern, Christian Hofer, Diego Guidolin, Andrea Porzionato, Anna Rambaldo, Raffaele De Caro, Francesco Piccione, Andrea Marcante, Sandra Zampieri
Our previous studies have shown that severely atrophic Quadriceps muscles of spinal cord injury (SCI) patients suffering with complete conus and cauda equina lesions, and thus with permanent denervation-induced atrophy and degeneration of muscle fibers, were almost completely rescued to normal size after two years of home-based Functional Electrical Stimulation (h-bFES). Since we used large surface electrodes to stimulate the thigh muscles, we wanted to know if the skin was affected by long-term treatment. Here we report preliminary data of morphometry of skin biopsies harvested from legs of 3 SCI patients before and after two years of h-bFES to determine the total area of epidermis in transverse skin sections...
January 12, 2018: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29685166/automated-vmat-planning-for-postoperative-adjuvant-treatment-of-advanced-gastric-cancer
#4
Abdul Wahab M Sharfo, Florian Stieler, Oskar Kupfer, Ben J M Heijmen, Maarten L P Dirkx, Sebastiaan Breedveld, Frederik Wenz, Frank Lohr, Judit Boda-Heggemann, Daniel Buergy
BACKGROUND: Postoperative/adjuvant radiotherapy of advanced gastric cancer involves a large planning target volume (PTV) with multi-concave shapes which presents a challenge for volumetric modulated arc therapy (VMAT) planning. This study investigates the advantages of automated VMAT planning for this site compared to manual VMAT planning by expert planners. METHODS: For 20 gastric cancer patients in the postoperative/adjuvant setting, dual-arc VMAT plans were generated using fully automated multi-criterial treatment planning (autoVMAT), and compared to manually generated VMAT plans (manVMAT)...
April 23, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29679247/neuromuscular-and-electromechanical-properties-of-ultra-power-athletes-the-traceurs
#5
Sidney Grosprêtre, Philippe Gimenez, Alain Martin
PURPOSE: Practising a power-type activity over years can shape the neuromuscular profile of athletes. This study aimed at comparing the neuromuscular profile of a non-trained group (NT, n = 10) to power athletes practising Parkour (= traceurs, group PK, n = 11), an activity consisting of jumping obstacles mostly in an urban landscape. METHODS: Maximal isometric plantar flexion force (MVC) and rate of torque development (RTD) were evaluated, and neuromuscular function of triceps surae muscles was assessed and compared between groups through the analysis of evoked potentials from posterior tibial nerve stimulation...
April 20, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29675332/50-hz-volumetric-functional-imaging-with-continuously-adjustable-depth-of-focus
#6
Rongwen Lu, Masashi Tanimoto, Minoru Koyama, Na Ji
Understanding how neural circuits control behavior requires monitoring a large population of neurons with high spatial resolution and volume rate. Here we report an axicon-based Bessel beam module with continuously adjustable depth of focus (CADoF), that turns frame rate into volume rate by extending the excitation focus in the axial direction while maintaining high lateral resolutions. Cost-effective and compact, this CADoF Bessel module can be easily integrated into existing two-photon fluorescence microscopes...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29674264/ultrasonic-modulation-of-neural-circuit-activity
#7
REVIEW
William J Tyler, Shane W Lani, Grace M Hwang
Ultrasound (US) is recognized for its use in medical imaging as a diagnostic tool. As an acoustic energy source, US has become increasingly appreciated over the past decade for its ability to non-invasively modulate cellular activity including neuronal activity. Data obtained from a host of experimental models has shown that low-intensity US can reversibly modulate the physiological activity of neurons in peripheral nerves, spinal cord, and intact brain circuits. Experimental evidence indicates that acoustic pressures exerted by US act, in part, on mechanosensitive ion channels to modulate activity...
April 16, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29671028/biochemical-profiling-of-rat-embryonic-stem-cells-grown-on-electrospun-polyester-fibers-using-synchrotron-infrared-microspectroscopy
#8
Ernesto Doncel-Pérez, Gary Ellis, Christophe Sandt, Peter S Shuttleworth, Agatha Bastida, Julia Revuelta, Eduardo García-Junceda, Alfonso Fernández-Mayoralas, Leoncio Garrido
Therapeutic options for spinal cord injuries are severely limited; current treatments only offer symptomatic relief and rehabilitation focused on educating the individual on how to adapt to their new situation to make best possible use of their remaining function. Thus, new approaches are needed, and interest in the development of effective strategies to promote the repair of neural tracts in the central nervous system inspired us to prepare functional and highly anisotropic polymer scaffolds. In this work, an initial assessment of the behavior of rat neural progenitor cells (NPCs) seeded on poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) fiber scaffolds using synchrotron-based infrared microspectroscopy (SIRMS) is described...
April 18, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29667130/beneficial-effects-of-the-calcium-channel-blocker-ctk-01512-2-in-a-mouse-model-of-multiple-sclerosis
#9
Rodrigo B M Silva, Samuel Greggio, Gianina T Venturin, Jaderson C da Costa, Marcus V Gomez, Maria M Campos
Voltage-gated calcium channels (VGCCs) play a critical role in neuroinflammatory diseases, such as multiple sclerosis (MS). CTK 01512-2 is a recombinant version of the peptide Phα1β derived from the spider Phoneutria nigriventer, which inhibits N-type VGCC/TRPA1-mediated calcium influx. We investigated the effects of this molecule in the mouse model of experimental autoimmune encephalomyelitis (EAE). The effects of CTK 01512-2 were compared to those displayed by ziconotide-a selective N-type VGCC blocker clinically used for chronic pain-and fingolimod-a drug employed for MS treatment...
April 17, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29664238/testing-of-a-new-portable-device-for-dynamic-bladder-pressure-monitoring
#10
Lingfeng Liu, Kang Zhao, Fan Chen, Jian Wu, Zhaofeng Yang, Ming Chen, Linbo Mao, Jiurong Han
OBJECTIVE: To develop a portable dynamic bladder pressure monitoring device for facilitating the monitoring of bladder detrusor pressure in patients with neurogenic bladder (NB) caused by spinal cord injury and further compared the effect with traditional urodynamics devices. METHODS: Portable dynamic bladder pressure monitoring device was implemented by software and hardware. The hardware was mainly composed of seven parts, such as micro liquid pressure sensor, electric bridge amplifying circuit, clock module, SD card storage circuit, liquid crystal display circuit, touch circuit, controller circuit and so on...
May 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29656686/lipopolysaccharide-from-rhodobacter-sphaeroides-tlr4-antagonist-attenuates-hypersensitivity-and-modulates-nociceptive-factors
#11
Agnieszka M Jurga, Ewelina Rojewska, Wioletta Makuch, Joanna Mika
CONTEXT: Accumulating evidence has demonstrated that Toll-like receptors (TLRs), especially TLR4 localized on microglia/macrophages, may play a significant role in nociception. OBJECTIVE: We examine the role of TLR4 in a neuropathic pain model. Using behavioural/biochemical methods, we examined the influence of TLR4 antagonist on levels of hypersensitivity and nociceptive factors whose contribution to neuropathy development has been confirmed. MATERIALS AND METHODS: Behavioural (von Frey's/cold plate) tests were performed with Wistar male rats after intrathecal administration of a TLR4 antagonist (LPS-RS ULTRAPURE (LPS-RSU), 20 μG: lipopolysaccharide from Rhodobacter sphaeroides, InvivoGen, San Diego, CA) 16 H and 1 h before chronic constriction injury (cci) to the sciatic nerve and then daily for 7 d...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29649627/overexpression-of-hipk2-attenuates-spinal-cord-injury-in-rats-by-modulating-apoptosis-oxidative-stress-and-inflammation
#12
Renbo Li, Jingbo Shang, Wei Zhou, Li Jiang, Donghui Xie, Guanjun Tu
HIPK2 is considered to be a tumor suppressor. It also has been implicated in several functions such as apoptosis and inflammation that are linked to spinal cord injury (SCI). However, whether HIPK2 ameliorates the neurological pain of SCI remains unclear. Here, we investigated the effects of HIPK2 on neurological function, oxidative stress, levels of inflammatory cytokines and expression of Bcl-2/Bax in an SCI model. Firstly, we evaluated the therapeutic effects of HIPK2 on neurological pain in the SCI rat using the Basso, Beattie and Bresnahan scores and H & E staining...
April 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29649262/antinociceptive-antibiotics-loaded-into-solid-lipid-nanoparticles-of-prolonged-release-measuring-pharmacological-efficiency-and-time-span-on-chronic-monoarthritis-rats
#13
Carlos Valdes, Gonzalo Bustos, Jose L Martinez, Claudio Laurido
Pain is a sensory experience of a complex physiological nature in which is not only involved the nervous system. Among its many features is the development of chronic pain that is more complicated to treat because of the central somatization processes involved, becoming inefficient treatments used in other forms of pain. Among them is the role of glial cells, whose participation is such that some authors have proposed to chronic pain as a gliopathy. Because of this, the drug target of possible treatments focuses on modulating nociceptive response affecting transduction into the central nervous system through affecting synapses in the dorsal horn of the spinal cord...
2018: PloS One
https://www.readbyqxmd.com/read/29644098/hydrogel-based-scaffolds-to-support-intrathecal-stem-cell-transplantation-as-a-gateway-to-the-spinal-cord-clinical-needs-biomaterials-and-imaging-technologies
#14
REVIEW
J Miguel Oliveira, Luisa Carvalho, Joana Silva-Correia, Sílvia Vieira, Malgorzata Majchrzak, Barbara Lukomska, Luiza Stanaszek, Paulina Strymecka, Izabela Malysz-Cymborska, Dominika Golubczyk, Lukasz Kalkowski, Rui L Reis, Miroslaw Janowski, Piotr Walczak
The prospects for cell replacement in spinal cord diseases are impeded by inefficient stem cell delivery. The deep location of the spinal cord and complex surgical access, as well as densely packed vital structures, question the feasibility of the widespread use of multiple spinal cord punctures to inject stem cells. Disorders characterized by disseminated pathology are particularly appealing for the distribution of cells globally throughout the spinal cord in a minimally invasive fashion. The intrathecal space, with access to a relatively large surface area along the spinal cord, is an attractive route for global stem cell delivery, and, indeed, is highly promising, but the success of this approach relies on the ability of cells (1) to survive in the cerebrospinal fluid (CSF), (2) to adhere to the spinal cord surface, and (3) to migrate, ultimately, into the parenchyma...
2018: NPJ Regenerative Medicine
https://www.readbyqxmd.com/read/29642434/a-single-dose-of-atorvastatin-applied-acutely-after-spinal-cord-injury-suppresses-inflammation-apoptosis-and-promotes-axon-outgrowth-which-might-be-essential-for-favorable-functional-outcome
#15
Katarina Bimbova, Maria Bacova, Alexandra Kisucka, Jaroslav Pavel, Jan Galik, Peter Zavacky, Martin Marsala, Andrea Stropkovska, Jana Fedorova, Stefania Papcunova, Jana Jachova, Nadezda Lukacova
The aim of our study was to limit the inflammatory response after a spinal cord injury (SCI) using Atorvastatin (ATR), a potent inhibitor of cholesterol biosynthesis. Adult Wistar rats were divided into five experimental groups: one control group, two Th9 compression (40 g/15 min) groups, and two Th9 compression + ATR (5 mg/kg, i.p.) groups. The animals survived one day and six weeks. ATR applied in a single dose immediately post-SCI strongly reduced IL-1β release at 4 and 24 h and considerably reduced the activation of resident cells at one day post-injury...
April 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29629874/object-discrimination-using-electrotactile-feedback
#16
Tapas Jaywant Arakeri, Brady A Hasse, Andrew J Fuglevand
A variety of bioengineering systems are being developed to restore tactile sensations in individuals who have lost somatosensory feedback because of spinal cord injury, stroke, or amputation. These systems typically detect tactile force with sensors placed on an insensate hand (or prosthetic hand in the case of amputees) and deliver touch information by electrically or mechanically stimulating sensate skin above the site of injury. Successful object manipulation, however, also requires proprioceptive feedback representing the configuration and movements of the hand and digits...
April 9, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29628628/a-treatment-planning-method-for-better-management-of-radiation-induced-oral-mucositis-in-locally-advanced-head-and-neck-cancer
#17
Hao Howard Zhang, Warren D D'Souza
Purpose/Aim: To describe a two-phase intensity-modulated radiation therapy (IMRT) treatment planning approach, that is, promising for reduction of oral mucositis risk in locally advanced head-and-neck cancer. Materials and Methods: Ten locally advanced head-and-neck cancer patients who underwent RT were retrospectively collected. Conventional IMRT and volumetric-modulated arc therapy (VMAT) plans were generated for these patients following clinical protocol. Following the first phase of generating conventional IMRT plans, our approach utilized data from Monte Carlo-based kernel superposition dose calculations corresponding to beam apertures (generated from the conventional IMRT plans) and used an exact mathematical programming-based optimization approach applying linear programming (LP) to dose optimization in the second phase...
January 2018: Journal of Medical Physics
https://www.readbyqxmd.com/read/29627871/autonomic-regulation-and-ventricular-arrhythmias
#18
REVIEW
Lingjin Meng, Kalyanam Shivkumar, Olujimi Ajijola
Autonomic nervous system (ANS) has a crucial role of regulating cardiac function in the physiological state and contributes to the pathogenesis of arrhythmias in the diseased state. The cardiac neuraxis consists of multiple feedback loops consisting of efferent and afferent limbs, mediating neurotransmission to and from the heart. Efferent parasympathetic neurotransmission is mediated by the vagus nerve, while paravertebral sympathetic ganglia relay efferent sympathetic neurotransmission to the heart. The association between autonomic activity and ventricular arrhythmias (VAs) has been studied extensively in both experimental models and humans...
April 7, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29625589/intramuscular-transplantation-of-bone-marrow-cells-prolongs-the-lifespan-of-sod1-g93a-mice-and-modulates-expression-of-prognosis-biomarkers-of-the-disease
#19
Amaya Rando, Diego Pastor, Mari Carmen Viso-León, Anna Martínez, Raquel Manzano, Xavier Navarro, Rosario Osta, Salvador Martínez
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive muscle weakness, paralysis and death. There is no effective treatment for ALS and stem cell therapy has arisen as a potential therapeutic approach. METHODS: SOD1 mutant mice were used to study the potential neurotrophic effect of bone marrow cells grafted into quadriceps femoris muscle. RESULTS: Bone marrow intramuscular transplants resulted in increased longevity with improved motor function and decreased motoneuron degeneration in the spinal cord...
April 6, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29623939/cell-cycle-and-complement-inhibitors-may-be-specific-for-treatment-of-spinal-cord-injury-in-aged-and-young-mice-transcriptomic-analyses
#20
Ming Hao, Xin-Ran Ji, Hua Chen, Wei Zhang, Li-Cheng Zhang, Li-Hai Zhang, Pei-Fu Tang, Ning Lu
Previous studies have reported age-specific pathological and functional outcomes in young and aged patients suffering spinal cord injury, but the mechanisms remain poorly understood. In this study, we examined mice with spinal cord injury. Gene expression profiles from the Gene Expression Omnibus database (accession number GSE93561) were used, including spinal cord samples from 3 young injured mice (2-3-months old, induced by Impactor at Th9 level) and 3 control mice (2-3-months old, no treatment), as well as 2 aged injured mice (15-18-months old, induced by Impactor at Th9 level) and 2 control mice (15-18-months old, no treatment)...
March 2018: Neural Regeneration Research
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