keyword
https://read.qxmd.com/read/38464029/oncogenic-gnas-drives-a-gastric-pylorus-program-in-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#21
Vincent Quoc-Huy Trinh, Katherine E Ankenbauer, Jiayue Liu, Maelle Batardiere, H Carlo Maurer, Celina Copeland, Jahg Wong, Olivia Ben-Levy, Sabrina M Torbit, Brenda Jarvis, Frank Revetta, Sergey Ivanov, Nidhi Jyotsana, Yuki Makino, Amanda M Ruelas, Anna L Means, Anirban Maitra, Marcus C B Tan, Kathleen E DelGiorno
OBJECTIVE: Intraductal Papillary Mucinous Neoplasms (IPMNs) are cystic lesions and bona fide precursors for pancreatic ductal adenocarcinoma (PDAC). Recently, we showed that acinar to ductal metaplasia, an injury repair program, is characterized by a transcriptomic program similar to gastric spasmolytic polypeptide expressing metaplasia (SPEM), suggesting common mechanisms of reprogramming between the stomach and pancreas. The aims of this study were to assay IPMN for pyloric markers and to identify molecular drivers of this program...
February 28, 2024: bioRxiv
https://read.qxmd.com/read/38463732/microcystic-serous-cystadenoma-of-the-pancreas-causing-biliary-obstruction-a-case-report-and-review-of-the-literature
#22
Sydney Bland, William Thompson Iii
Cystic tumors account for 15% of pancreatic tumors. Of these, serous microcystic adenomas represent 1-2% of pancreatic exocrine neoplasms. While typically benign, a small percentage possess malignant potential. Given imaging improvements, serous cystadenomas are being identified more frequently. A 63-year-old female was admitted with complaints of jaundice and unintentional weight loss. Abdominal computed tomography scan showed a 16 cm obstructive pancreatic mass near the porta hepatis region. Endoscopic ultrasonography and fine needle aspiration biopsy indicated a large pancreatic head cystic mass favoring serous microcystadenoma causing biliary and some pyloric obstruction...
March 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38460151/multidisciplinary-approach-for-the-management-of-metastatic-poorly-differentiated-neuroendocrine-carcinoma-of-the-pancreas-a-case-report-of-an-exceptional-responder
#23
JOURNAL ARTICLE
Elizabeth S Nakasone, Hannah C Bustillos, Xianyong Gui, Eric Q Konnick, Jonathan G Sham, Stacey A Cohen
Poorly differentiated pancreatic neuroendocrine carcinomas (pNECs) are rare, highly aggressive neoplasms. Frequently metastatic at diagnosis, prognosis is poor with median overall survival estimated to be less than 1 year. Although multidisciplinary management, including systemic medications and locoregional therapies aimed at reducing and preventing symptoms caused by mass effect, is the mainstay of treatment for patients with metastatic well-differentiated pancreatic neuroendocrine tumors, rapid progression, organ dysfunction, and poor performance status often preclude initiation of even single-modality palliative chemotherapy for patients with metastatic pNEC, limiting the use of and recommendation for multidisciplinary management...
March 6, 2024: Pancreas
https://read.qxmd.com/read/38450737/does-the-duration-of-diabetes-increase-the-risk-of-cancer-a-nationwide-population-based-cohort-of-patients-with-new-onset-diabetes-and-a-matched-reference-cohort
#24
JOURNAL ARTICLE
Petrus Lohi, Anssi Auvinen, Leo Niskanen, Timo Partonen, Jari Haukka
Diabetes mellitus and cancer are both common health issues, but the correlation between these two diseases remains unclear. We investigated the association of cumulative exposure of diabetes mellitus as an indication of hyperglycemia in terms of disease duration on multiple cancer types. We hypothesized that the risk of cancer would increase over time after the onset of diabetes. The study population consisted of a population-based cohort of 398,708 people and it was constructed from the Finnish CARING project...
March 7, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38449999/inoperable-renal-malignant-glomus-tumor-the-answers-for-all-the-w-s
#25
JOURNAL ARTICLE
Pushkala Surianarayanan, Arun Ramdas Menon, Shriley Sundersingh, Anand Raja
Glomus tumor, arising from glomus bodies (specialized neurovascular structures involved in thermoregulation), commonly occurs in extremities and rarely in viscera. The spectrum of glomus tumors range from benign tumors to tumors with uncertain malignant potential to tumors of the malignant subtype. A vast majority of visceral glomus tumors are benign. Most common visceral tumors arise in the gastrointestinal tract. Glomus tumors of the kidney are a rare entity of which malignant glomus tumors are exceedingly rare...
2024: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/38449416/-two-cases-of-portal-vein-stent-placement-for-portal-vein-stenosis-due-to-recurrence-of-pancreatic-cancer
#26
JOURNAL ARTICLE
Hirotaka Yuki, Mitsuyoshi Okazaki, Kaoru Katano, Akihiro Sugita, Tomokazu Tokoro, Ryosuke Gabata, Satoshi Takada, Shinichi Nakanuma, Isamu Makino, Shintaro Yagi
We report 2 cases of portal vein stent placement for malignant portal stenosis due to recurrence of pancreatic cancer with symptoms of portal hypertension. Case 1: The patient was a 68-year-old female. Five years ago, a mass was found around the aorta on a computerized tomography(CT)scan taken after a residual pancreatectomy for pancreatic cancer. It was diagnosed as lymph node recurrence and S-1 therapy was started. As further tumor enlargement led to portal vein compression, venostasis around the ascending jejunum, anemia, and black stools, a portal vein stent was placed...
February 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38449407/-a-case-of-left-upper-abdominal-evisceration-for-transverse-colon-cancer-with-multiple-organ-invasion
#27
JOURNAL ARTICLE
Masato Fujino, Masahiro Amano, Fumie Osuga, Masatoshi Yoshizawa, Akina Kuwahara, Satoaki Kimura, Shinichiro Usuki, Norihito Hosoi, Yukinobu Shuto, Kunihisa Miyazaki
The case is a 73-year-old woman. She visited primary care doctor for abdominal pain, vomiting, diarrhea, and melena that persisted for 2 weeks. She was referred to our department because she had an elevated inflammatory response and CT showed a mass in her left upper quadrant. Contrast-enhanced CT showed a tumorous lesion mainly in the splenic flexure of the transverse colon, involving the greater curvature of the stomach, the tail of the pancreas, and the hilus of the spleen, accompanied by abscess formation...
February 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38449405/-a-case-of-long-term-response-to-chemotherapy-in-mucinous-carcinoma-of-the-duodenum-with-multiple-distant-metastases
#28
JOURNAL ARTICLE
Takashi Komatsubara, Koji Fujimoto, Hideaki Miyabe, Yuma Tanigawa, Wataru Kumode, Eisei Mitsuoka, Tetsuo Maeda, Masayuki Ishii
Primary carcinoma of the duodenum, especially mucinous carcinoma of the duodenum, is extremely rare. We present a case of a long-term response to chemotherapy in mucinous carcinoma of the duodenum with multiple distant metastases. A 60-year-old man was admitted to our hospital with epigastric pain and jaundice. CT showed a thickening of the duodenal wall; extensive lymphadenopathy around the head of the pancreas, in the para-aortic region and the mediastinum; suspected peritoneal dissemination; lung metastases; and bone metastases...
February 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38448752/early-onset-pancreatic-cancer-exploring-contemporary-treatment-and-outcomes-using-real-world-data
#29
JOURNAL ARTICLE
Shehara Mendis, Lara Lipton, Yat Hang To, Sumitra Ananda, Michael Michael, Sue-Anne McLachlan, Benjamin Thomson, Benjamin Loveday, Brett Knowles, Adrian Fox, Mehrdad Nikfarjam, Val Usatoff, Julia Shapiro, Kate Clarke, Sharon Pattison, Cheng Ean Chee, Rob Zielinski, Rachel Wong, Peter Gibbs, Belinda Lee
BACKGROUND: Pancreatic cancer incidence is increasing in younger populations. Differences between early onset pancreatic cancer (EOPC) and later onset pancreatic cancer (LOPC), and how these should inform management warrant exploration in the contemporary setting. METHODS: A prospectively collected multi-site dataset on consecutive pancreatic adenocarcinoma patients was interrogated. Patient, tumour, treatment, and outcome data were extracted for EOPC (≤50 years old) vs LOPC (>50 years old)...
March 6, 2024: British Journal of Cancer
https://read.qxmd.com/read/38448620/outcome-and-survival-were-similar-with-laparoscopic-and-open-pancreatectomy-in-102-solid-pseudopapillary-neoplasms
#30
JOURNAL ARTICLE
Tatiana Codjia, Lancelot Marique, Béatrice Aussilhou, Fadhel Samir Ftériche, Louis de Mestier, Vinciane Rebours, Jérome Cros, Philippe Ruszniewski, Philippe Lévy, Mickael Lesurtel, Alain Sauvanet, Safi Dokmak
BACKGROUND: Solid pseudopapillary neoplasms of the pancreas (SPNP) are rare tumors predominantly in young women. We report the largest single-center cohort study comparing resection of SPNP by laparoscopic approach (LA) and the open approach (OA). METHOD: Between 2001 and 2021, 102 patients (84% women, median age: 30) underwent pancreatectomy for SPNP and were retrospectively studied. Demographic, perioperative, pathological, early and the long-term results were evaluated between patients operated by LA and those by OA...
March 6, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38448348/association-of-autoimmune-pancreatitis-and-intraductal-papillary-mucinous-neoplasm-a-retrospective-analysis-from-a-tertiary-care-referral-center
#31
JOURNAL ARTICLE
Marco Lanzillotta, Lino Iago Belli, Giulio Belfiori, Diego Palumbo, Marco Schiavo-Lena, Gabriele Capurso, Paolo Giorgio Arcidiacono, Lorenzo Dagna, Massimo Falconi, Stefano Crippa, Emanuel Della-Torre
BACKGROUND: Autoimmune Pancreatitis (AIP) is a rare chronic inflammatory disease affecting the pancreas. Chronic pancreatic inflammation represents a risk factor for pre-neoplastic conditions such as Intraductal Papillary Mucinous Neoplasia (IPMN). Due to the rarity of AIP, the incidence, and clinical features of IPMN occurring in AIP patients remains unknown. AIMS: In the present study we aimed to explore the relationship between AIP and IPMN and to characterize the clinical features and outcomes of IPMN occurring in the context of AIP...
March 1, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38445913/twenty-one-years-of-experience-with-resected-solid-pseudopapillary-neoplasm-a-retrospective-single-institutional-cohort-study
#32
JOURNAL ARTICLE
Soo Yeun Lim, Hochang Chae, Hyejeong Jeong, So Jeong Yoon, Hongbeom Kim, In Woong Han, Jin Seok Heo, Sang Hyun Shin
BACKGROUND: Although the incidence of solid pseudopapillary neoplasm (SPN) is <2% of the incidence of pancreatic tumor, the prevalence seems to be increasing. SPNs are mostly benign. However, they also show malignant features. This study aimed to identify the clinical outcomes of patients who underwent surgery for SPN at a single center. METHODS: Data on 217 patients with SPN who underwent surgery in Samsung Medical Center between 2000 and 2020 were retrospectively analyzed...
March 2024: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38444882/methotrexate-associated-lymphoproliferative-disorder-a-rare-pancreatic-tumor-diagnosed-via-endoscopic-ultrasound-guided-fine-needle-biopsy
#33
Koh Kitagawa, Masafumi Oyama, Shohei Asada, Shinya Sato, Tatsuya Nakatani, Naoki Nishimura, Yuka Mui, Jun-Ichi Hanatani, Maiko Takeda, Hitoshi Yoshiji
A 73-year-old woman with a history of rheumatoid arthritis treated with methotrexate (MTX) for the last 10 years was referred to our hospital for a pancreatic tumor examination. Contrast-enhanced abdominal computed tomography revealed a 20-mm-diameter hypovascular tumor in the pancreatic tail. A hypoechoic mass with heterogeneous internal echo was found on an endoscopic ultrasound (EUS). An EUS-guided fine-needle biopsy (EUS-FNB) was performed with a 22-gauge Franseen-tip needle. Histologic examination of EUS-FNB specimens from the pancreatic tumor revealed the proliferation of atypical spindle cells...
April 2024: DEN Open
https://read.qxmd.com/read/38443232/natural-history-and-growth-prediction-model-of-pancreatic-serous-cystic-neoplasms
#34
JOURNAL ARTICLE
Jenny H Chang, Breanna C Perlmutter, Chase Wehrle, Robert Naples, Kathryn Stackhouse, John McMichael, Tu Chao, Samer Naffouje, Toms Augustin, Daniel Joyce, Robert Simon, R Matthew Walsh
OBJECTIVE: Serous cystic neoplasms (SCN) are benign pancreatic cystic neoplasms that may require resection based on local complications and rate of growth. We aimed to develop a predictive model for the growth curve of SCNs to aid in the clinical decision making of determining need for surgical resection. METHODS: Utilizing a prospectively maintained pancreatic cyst database from a single institution, patients with SCNs were identified. Diagnosis confirmation included imaging, cyst aspiration, pathology, or expert opinion...
February 28, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38438247/serum-and-tissue-metallome-of-pancreatic-ductal-adenocarcinoma
#35
JOURNAL ARTICLE
Sooin Byeon, Taymin du Toit-Thompson, Luke Hipperson, Sarah Maloney, Ross Wenzel, Anthony J Gill, Jaswinder S Samra, Anubhav Mittal, Sumit Sahni
Pancreatic ductal adenocarcinoma (PDAC) patients have late presentation at the time of diagnosis and a poor prognosis. Metal dyshomeostasis is known to play a role in cancer progression. However, the blood and tissue metallome of PDAC patients has not been assessed. This study aimed to determine the levels of essential and toxic metals in the serum and pancreatic tissue from PDAC patients. Serum samples were obtained from PDAC patients before surgical resection. Tissue (tumor and adjacent normal pancreas) were obtained from the surgically resected specimen...
March 4, 2024: Cancer Science
https://read.qxmd.com/read/38436765/familial-pancreatic-cancer-a-long-fruitful-journey
#36
REVIEW
Teresa A Brentnall
In the early years of my GI fellowship, a healthy 40-year-old man came to my clinic and announced that he was going to die of pancreatic cancer. His brothers, father and uncles had all died of the disease; he felt his fate was inescapable. I asked whether his family members had seen doctors or had any tests. His answer was yes to both. Even so, doctors could not diagnose the pancreatic cancer at early stages. CT scans were always negative. I thought to myself, in order to help this patient-CT scans may not be reliable for early detection...
March 4, 2024: Familial Cancer
https://read.qxmd.com/read/38434685/genetic-prediction-of-the-causal-relationship-between-schizophrenia-and-tumors-a-mendelian-randomized-study
#37
JOURNAL ARTICLE
Xintong Zhou, Qi Liu, Shihan Liu, Liquan Wang, Zhongli Sun, Changgang Sun, Xiangning Cui
BACKGROUND: Patients with schizophrenia are at a higher risk of developing cancer. However, the causal relationship between schizophrenia and different tumor types remains unclear. METHODS: Using a two-sample, two-way Mendelian randomization method, we used publicly available genome-wide association analysis (GWAS) aggregate data to study the causal relationship between schizophrenia and different cancer risk factors. These tumors included lung adenocarcinoma, lung squamous cell carcinoma, small-cell lung cancer, gastric cancer, alcohol-related hepatocellular cancer, tumors involving the lungs, breast, thyroid gland, pancreas, prostate, ovaries and cervix, endometrium, colon and colorectum, and bladder...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38432990/small-insulinoma-followed-up-as-an-indolent-pancreatic-tumor-a-case-report
#38
JOURNAL ARTICLE
Hiroki Sato, Shozaburo Fujii, Tetsuhiro Okada, Hidemasa Kawabata, Yuki Kamikokura, Mikihiro Fujiya
A woman in her 60s presented with a small pancreatic head tumor. Imaging studies revealed a 13-mm well-defined pancreatic head tumor. A neuroendocrine neoplasm was suspected, and the patient opted for observation at that time. After 8 months, the patient began experiencing sweating while fasting, and blood tests during regular follow-up visits showed hypoglycemia. Hypoglycemia was induced during fasting test. The tumor exhibited clear features of an insulinoma during follow-up observation. While small neuroendocrine neoplasms are often managed through observation, caution should be exercised regarding their transformation into functional neuroendocrine tumors...
March 4, 2024: Internal Medicine
https://read.qxmd.com/read/38432676/-current-status-and-considerations-on-clinical-application-of-function-preserving-pancreatic-surgery
#39
JOURNAL ARTICLE
D Li, K Qin, J B Jin, C H Peng
For pancreatic neoplasms, the current clinical treatment strategy is mainly using standard surgical methods, including pancreaticoduodenectomy, distal pancreatectomy with splenectomy, and total pancreatectomy. Standard surgical methods require a larger resection, including resection of some surrounding organs and a large amount of pancreatic parenchyma. The endocrine and exocrine functions of the pancreas are easily damaged. Moreover, since the standard surgical procedure involves the reconstruction of the digestive tract at multiple anastomoses, there is a high risk of pancreatic, biliary, and intestinal fistulas occurring postoperatively...
March 1, 2024: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://read.qxmd.com/read/38426360/unveiling-lipid-rich-clear-cell-pancreatic-neuroendocrine-tumor-a-small-series-of-two-cases-with-literature-review
#40
JOURNAL ARTICLE
Rong Xia, Laura H Tang, Negin Shafizadeh, Yue Xue, Xiaoying Liu
This study presents two cases of lipid-rich pancreatic neuroendocrine tumors (PanNETs), a rare variant posing significant diagnostic challenges in fine needle aspiration (FNA) cytology and small biopsies. The first case involves an elderly male with a pancreatic tumor, displaying distinct cytoplasmic vacuoles, while the second case is a middle-aged male present with a pancreatic tail mass exhibiting foamy cytoplasm and eccentric nuclei, infiltrating in the stroma. Both cases did not exhibit typical morphologic features of PanNET but demonstrated cytomorphologic features and infiltrative growth patterns that mimicked adenocarcinoma...
March 1, 2024: Diagnostic Cytopathology
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