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Pancreas neoplasm

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https://www.readbyqxmd.com/read/29776636/molecular-diagnostics-in-the-neoplasms-of-the-pancreas-liver-gallbladder-and-extrahepatic-biliary-tract-2018-update
#1
REVIEW
Lei Zhang, Martin H Bluth, Amarpreet Bhalla
Pancreatic neoplasms, including ductal adenocarcinoma, solid pseudopapillary neoplasm, pancreatic endocrine neoplasms, acinar cell carcinoma, and pancreatoblastoma, are associated with different genetic abnormalities. Hepatic adenomas with beta-catenin exon 3 mutation are associated with a high risk of malignancy. Hepatic adenoma with arginosuccinate synthetase 1 expression or sonic hedgehog mutations are associated with a risk of bleeding. Hepatocellular carcinoma and choangiocarcinoma display heterogeneity at both morphologic and molecular levels Cholangiocellular carcinoma is most commonly associated with IDH 1/2 mutations...
June 2018: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/29771766/prevalence-of-extrapancreatic-malignancies-among-patients-with-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#2
Nikola Panic, Federico Macchini, Sonia Solito, Stefania Boccia, Emanuele Leoncini, Alberto Larghi, Debora Berretti, Sara Pevere, Salvatore Vadala, Marco Marino, Maurizio Zilli, Milutin Bulajic
OBJECTIVES: We conducted a study in order to assess the prevalence of extrapancreatic malignancies (EPMs) in a cohort of patients with intraductal papillary mucinous neoplasms (IPMNs) from northeast of Italy. METHODS: A study was conducted in hospital Santa Maria della Misericordia, Udine, Italy. Hospital records were screened in order to identify newly diagnosed IPMN cases in the period from January 1, 2009, to December 31, 2015. We searched for EPMs diagnosed previous to, synchronous to, or after the IPMN...
May 17, 2018: Pancreas
https://www.readbyqxmd.com/read/29751773/an-unusual-finding-in-a-desmoid-type-fibromatosis-of-the-pancreas-a-case-report-and-review-of-the-literature
#3
Joseph Clarence Torres, Chen Xin
BACKGROUND: Desmoid-type fibromatoses are rare benign and fibrous tumors that account for approximately 0.03% of total neoplasms. Within this category of neoplasms, pancreatic desmoid-type fibromatosis is an extremely rare subgroup, accounting for approximately 5% of desmoid-type fibromatoses. Although the etiology is unknown, some risk factors include trauma, surgery, family history of desmoid tumor, pregnancy, use of contraceptives, genetic mutation, and familial adenomatous polyposis or Gardner syndrome...
May 12, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29750003/dedifferentiated-retroperitoneal-liposarcoma-spontaneously-occurring-in-an-aged-sd-rat
#4
Tomoharu Naito, Tsuyoshi Saito, Tamami Higuchi, Akira Inomata, Takuo Hayashi, Yasuhiro Shimada, Atsuko Yamauchi-Ohguchi, Sayaka Kenmochi, Chihaya Kakinuma, Takashi Yao
Liposarcoma is a rare neoplasm in rats and is characterized by the presence of lipoblasts containing multiple cytoplasmic vacuoles. We encountered a rare type of liposarcoma in a male SD (Crj:CD(SD)IGS) rat during a long-term study to gather background data. At necropsy at 105 weeks of age, there was a large amount of fatty tissue covering the mesentery, pancreas, and retroperitoneum; a white nodule in the right kidney; and paleness of the liver. Microscopically, the tumor had a well-differentiated component and dedifferentiated high-grade component...
April 2018: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29744101/metastatic-renal-cell-carcinoma-presenting-with-melena
#5
Ashwini Sadhale, Abimbola Adike, Dora Lam-Himlin
Renal cell carcinoma is a highly malignant neoplasm. Metastasis to the pancreas and gastrointestinal tract is rare. In this case report, we show images of metastatic renal cell carcinoma to the upper gastrointestinal tract in a patient who presented with melena.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29742724/a-case-report-of-immunoglobulin-g4-related-sclerosing-cholangitis-with-multiple-relapse
#6
Xiaoqin Dong, Na Huo, Zhao Wu, Guiqiang Wang, He Wang, Hong Zhao
RATIONALE: Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) is classified as a biliary tract manifestation of immunoglobulin G4-related disease (IgG4-RD). Glucocorticoid is the first-line therapy for most patients, but the optimal starting dose, adequate maintaining dose and withdrawal time remain disputable. PATIENT CONCERNS: An elderly male patient presented to our hospital with neoplasms of the bile duct and pancreas at first visit in December 2011...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29741203/peptide-receptor-radionuclide-therapy-for-advanced-gastroenteropancreatic-neuroendocrine-tumors-from-oncology-perspective
#7
Agnieszka Kolasińska-Ćwikła, Anna Łowczak, Katarzyna Maciejkiewicz Maciejkiewicz, Jarosław Bogdan Ćwikła
Peptide Receptor Radionuclide Therapy (PRRT) is a form of molecular targeted therapy which is performed by using a small peptide (somatostatin analogue - SSA) that is coupled with a radionuclide beta emitting radiation. PRRT is a nuclear medicine for the systemic treatment of non-resectable, metastasized well/moderately differentiated, neuroendocrine tumours (NET) with overexpression of somatostatin receptor. These types of tumours include gastroenteropancreatic neoplasm (GEP-NENs), e.g. arising from the small bowel (often called carcinoid tumours), the pancreas, duodenum or stomach, but also from the large bowel or the lung and many other tissues (so called diffuse neuroendocrine system)...
2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29739948/a-meta-analysis-of-prognostic-factor-of-pancreatic-neuroendocrine-neoplasms
#8
Yong Gao, Hao Gao, Guangfu Wang, Lingdi Yin, Wenbin Xu, Yunpeng Peng, Junli Wu, Kuirong Jiang, Yi Miao
Pancreatic neuroendocrine neoplasms (pNENs) are a group of clinically rare and heterogeneous diseases of the pancreas. However, the prognostic factors for this disease in patients still remain controversial. The purpose of our study is to evaluate the predictive roles of those prognostic factors for pNENs. All related articles published until Sep 17, 2017 were identified via PubMed, EMBASE, Web of Science, Ovid and the Cochrane Library. Studies that examined the prognostic factors of pNENs were enrolled. 17 articles (2822 patients) were finally included in this study...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29738363/pancreatic-lipomatous-hamartoma-a-hitherto-unrecognized-variant
#9
Mariko Tanaka, Tetsuo Ushiku, Masako Ikemura, Yutaka Takazawa, Toru Igari, Michio Shimizu, Hiroshi Yamaguchi, Noriyoshi Fukushima, Kei Sakuma, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Takeyuki Watadani, Yousuke Nakai, Kazuhiko Koike, Masashi Fukayama
Pancreatic masses consisting of lipomatous components clinically include lipoma, liposarcoma, lipomatous pseudohypertrophy of the pancreas, fat-containing neoplasms such as perivascular epithelioid cell tumor, and malignant neoplasm with lipoid degeneration. We present pancreatic lipomatous hamartoma, which has not been reported hitherto. A solid pancreatic mass was detected from a computed tomographic scan check-up in each of 3 cases of Japanese men. Macroscopically, well-demarcated solid lipomatous masses were detected at the uncus, body, and tail of the pancreas, respectively...
May 4, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29737317/first-robotic-pylorus-preserving-pancreaticoduodenectomy-for-frantz-s-tumour-in-an-adolescent-girl
#10
Palanivelu Chinnusamy, Sumanta Dey, Bhushan Chittawadagi, Srivatsan Gurumurthy, Sandeep Sabnis, Senthilnathan Palanisamy
Solid pseudopapillary tumour (SPT) is one of the uncommon benign cystic neoplasms of pancreas occurring predominantly in young females. Being benign in nature, surgical resection is the treatment of choice with excellent 5-year survival. A 14-year-old girl presented with pain abdomen for 1 week. On evaluation, she was found to have a large SPT involving head and uncinate process of Pancreas She underwent robotic pylorus preserving pancreaticoduodenectomy (R-PPPD) with da Vinci® Si Robotic System (Intuitive Surgical, Sunnyvale, CA, USA)...
May 4, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29736662/serous-pancreatic-cystadenoma-with-compression-of-wirsung-s-duct
#11
Enio Campos Amico, José Roberto Alves, Adriano de Araújo Lima Liguori, Rogério Lacerda Sousa
Serous cystadenoma of the pancreas is a common cystic neoplasm typically of benign evolution that rarely communicates with the pancreatic ductal system. We present several images originating from two cases of serous cystadenoma of the pancreas which led to compression and dilatation of Wirsung's duct. These cases suggest that when the diagnosis of pancreatic microcystic lesion is detected, associated, or not associated with a central fibrous scar and a low carcinoembryonic antigen level in the aspirated fluid, the presence of dilatation of Wirsung's duct does not exclude the diagnosis of serous pancreatic cystadenoma...
May 7, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29732356/clinical-significance-of-pancreatic-intraepithelial-neoplasia-in-resectable-pancreatic-cancer-on-survivals
#12
Da-Young Yu, Young-Dong Yu, Wan-Bae Kim, Hyung-Joon Han, Sae-Byul Choi, Dong-Sik Kim, Sang-Yong Choi, Joo-Young Kim, Hyeyoon Chang, Baek-Hui Kim
Purpose: Noninvasive precursor lesions for pancreatic adenocarcinoma include pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. PanIN is often found synchronously adjacent to resected pancreatic ductal adenocarcinoma (PDAC) tumors. However, its prognostic significance on outcome after PDAC resection is unknown. The purpose of the current study was to determine if the presence of PanIN has a prognostic or predictive effect on survival after resection for PDAC with curative intent...
May 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29730906/predictors-of-malignancy-in-pure-branch-duct-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-without-enhanced-mural-nodules-on-ct-imaging-a-nationwide-multicenter-study
#13
Tae Hyeon Kim, Young Sik Woo, Hyung Ku Chon, Jin Hyeok Hwang, Kyo Sang Yoo, Woo Jin Lee, Kwang Hyuck Lee, Jong Kyun Lee, Seok Ho Dong, Chang Hwan Park, Eun Taek Park, Jong Ho Moon, Ho Gak Kim, Kwang Bum Cho, Hong Ja Kim, Seung Ok Lee, Young Koog Cheon, Jeong-Mi Lee, Jin Woo Park, Myung-Hwan Kim
Background/Aim: Enhanced mural nodules, which can be visualized using computed tomography (CT), constitute high-risk stigmata in branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs). Conversely, the absence of enhanced mural nodules on preoperative imaging does not exclude malignant risk. The present study aimed to investigate other morphological features as predictors of malignancy in "pure" BD-IPMNs without enhanced mural nodules on CT. Method: This retrospective study included 180 patients with surgically confirmed "pure" BD-IPMNs of the pancreas and no enhanced mural nodules on preoperative CT...
May 4, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29718872/anatomical-segmentectomy-of-the-pancreatic-head-along-the-embryological-fusion-plane-a-case-series-and-a-literature-review
#14
Chunfu Zhu, Zhongzhi Jia, Xudong Zhang, Qiang Yu, Xihu Qin
RATIONALE: Anatomical segmentectomy of the pancreatic head along the embryological fusion plane (EFP) has been used in the treatment of benign, borderline, and low-grade malignancy neoplasms. However, few studies have reported on the outcomes of this procedure. The aim of this study was to retrospectively assess the outcomes of anatomical segmentectomy of the pancreatic head along the EFP. PATIENT CONCERNS: We experienced two patients who underwent anatomical segmentectomy of the pancreatic head along the EFP for the treatment of pancreatic cystadenoma...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29706823/locally-advanced-carcinosarcoma-of-the-pancreas
#15
Sasha A Still, Carlos R Becerra, Stacia E Clement-Kruzel, Keith M Cavaness
Carcinosarcoma is a rare subtype of pancreatic neoplasm including both carcinomatous and sarcomatous components. Fewer than 30 cases have been reported to the Surveillance, Epidemiology, and End Results Program database. Given such rarity, definitive treatment guidelines are not well defined. We report a case of pancreatic carcinosarcoma diagnosed in our institution, review tumor clinicopathological characteristics, and describe our medical and surgical management strategy.
April 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29705715/solid-pseudopapillary-neoplasm-spn-of-the-testis-comprehensive-mutational-analysis-of-6-testicular-and-8-pancreatic-spns
#16
Kvetoslava Michalova, Michael Michal, Monika Sedivcova, Dmitry V Kazakov, Carlos Bacchi, Tatjana Antic, Marketa Miesbauerova, Ondrej Hes, Michal Michal
BACKGROUND: Recently, we came with the theory of a possible relationship between a group of testicular and pancreatic tumors. We used one case of a pancreatic analogue solid pseudopapillary neoplasm of the testis composed partially of areas reminiscent of solid pseudopapillary neoplasm (SPN) of the pancreas and partially of structures identical to primary signet ring stromal tumor of the testis (PSRSTT) as a connecting link between these two entities. After demonstrating that PSRSTT and pancreatic analogue SPN of the testis share the same immunoprofile and genetic features characteristic for pancreatic SPN, we came to the conclusion that pancreatic analogue SPN of the testis and PSRSTT represent a morphological spectrum of a single entity and that both are related to the pancreatic SPN...
April 20, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29705685/translational-genomics-in-pancreatic-ductal-adenocarcinoma-a-review-with-re-analysis-of-tcga-dataset
#17
REVIEW
Jeffery Ho, Xianchun Li, Lin Zhang, Yonghao Liang, Wei Hu, Johnny C W Yau, Hung Chan, Tony Gin, Matthew T V Chan, Gary Tse, William K K Wu
Malignancy of the pancreas is a leading cause of cancer-related mortality, with the highest case-fatality of all cancers. Nevertheless, the lack of sensitive biomarkers and presence of biological heterogeneity precludes its early detection and effective treatment. The recent introduction of next-generation sequencing allows characterization of multiple driver mutations at genome- and exome-wide levels. Sequencing of DNA and RNA from circulating tumour cells has also opened an exciting era of non-invasive procedures for tumour detection and prognostication...
April 25, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29702531/intraductal-papillary-mucinous-neoplasm-of-the-pancreas-as-the-main-focus-for-early-detection-of-pancreatic-adenocarcinoma
#18
Masao Tanaka
For early detection of pancreatic cancer, interests are now focused on the detection of high-risk individuals to undergo screening examinations. Intraductal papillary mucinous neoplasm (IPMN) is a unique dual precursor of pancreatic cancer, characterized by progression to invasive cancer and the development of pancreatic adenocarcinoma either concomitantly (synchronous occurrence) or even after resection of IPMN (metachronous occurrence). Careful examination and surveillance of patients with IPMN may therefore lead to early detection of pancreatic cancer...
May 2018: Pancreas
https://www.readbyqxmd.com/read/29696066/metastatic-neuroendocrine-pancreatic-tumor-case-report
#19
E C Radu, A I Saizu, R R Grigorescu, A E Croitoru, C Gheorghe
Rationale. Pancreatic neuroendocrine tumors (NETs) are rare neoplasms that develop from the endocrine tissues of the pancreas. They have a better overall prognosis than pancreatic adenocarcinoma. However, all commonly used classification systems reflect a separation between more indolent, well-differentiated tumors and far more aggressive poorly differentiated types that behave clinically more like small-cell carcinoma of the lung. Objective. To present the case of a 62-year-old man with an aggressive pancreatic NET, with liver, splenic and bone metastases who underwent multidisciplinary treatment including several lines of chemotherapy, somatostatin analogs and radiotherapy...
January 2018: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29695402/egfr-l861q-mutation-in-a-metastatic-solid-pseudopapillary-neoplasm-of-the-pancreas
#20
Kevin G Neill, James Saller, Sameer Al Diffalha, Barbara A Centeno, Mokenge P Malafa, Domenico Coppola
Solid-pseudopapillary neoplasm of the pancreas (SPN) is a rare neoplasm that is typically indolent in nature. Surgical resection is the preferred method of treatment and often associated with a good prognosis. Local invasion and metastasis have been reported in a small subset of patients. Currently, there are limited data on the molecular mutation profile of invasive and metastatic SPN. In this report, we present the case of a 38-year-old female with a locally-invasive and unresectable SPN that, despite exhaustive chemoradiotherapy, progressed to liver metastasis...
May 2018: Cancer Genomics & Proteomics
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