keyword
https://read.qxmd.com/read/38492812/radiation-therapy-quality-assurance-analysis-of-alliance-a021501-preoperative-mfolfirinox-or-mfolfirinox-plus-hypofractionated-radiation-therapy-for-borderline-resectable-adenocarcinoma-of-the-pancreas
#1
JOURNAL ARTICLE
Leila T Tchelebi, Diana Segovia, Koren Smith, Qian Shi, T J Fitzgerald, Michael D Chuong, Tyler J Zemla, Eileen M O'Reilly, Jeffrey Meyerhardt, Eugene J Koay, Jessica Leif, Ardaman Shergill, Matthew Hg Katz, Joseph M Herman
BACKGROUND: Alliance A021501 is the first randomized trial to evaluate stereotactic body radiation therapy (SBRT) for borderline resectable pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant chemotherapy. In this post hoc study, we reviewed the quality of radiation therapy (RT) delivered. METHODS: SBRT (6.6 Gy x 5) was intended, although hypofractionated RT (5 Gy x 5) (HIGRT) was permitted if SBRT specifications could not be met. Institutional credentialing through the National Cancer Institute-funded Imaging and Radiation Oncology Core (IROC) was required...
March 14, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38485867/nationwide-audit-of-postoperative-mortality-and-complications-after-digestive-cancer-surgery-will-new-legal-thresholds-be-sufficient
#2
JOURNAL ARTICLE
Jérémie Thereaux, Bogdan Badic, Basile Fuchs, Anais Caillard, Margaux Geier, Karin Lacut, Francis Couturaud, Jean-Philippe Metges
BACKGROUND: French policymakers recently chose to regulate high-risk digestive cancer surgery (DCS). A minimum of five cases per year should be performed for each of the following types of curative cancer surgery: esophagus/esogastric junction (ECS), stomach (GCS), liver (LCS, metastasis included), pancreas (PCS), and rectum (RCS). This study aimed to evaluate the hypothetical beneficial effects of the new legal minimal volume thresholds on the rates of 90-day postoperative mortality (90POM) for each high-risk DCS...
March 14, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38485866/aso-author-reflections-the-role-of-neoadjuvant-chemotherapy-in-invasive-intraductal-mucinous-neoplasms-of-the-pancreas
#3
JOURNAL ARTICLE
A Fogliati, Mark J Truty
No abstract text is available yet for this article.
March 14, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38482243/the-long-term-outcomes-and-prognostic-factors-about-locally-advanced-right-colon-cancer-a-retrospective-cohort-study
#4
JOURNAL ARTICLE
Changzheng Li, Zhenyu Li, Jiachen Zhang, Xijie Zhang, Matthew Yuan-Kun Wei, Nan Zun Teo, Pengfei Ma, Junli Zhang, Sen Li, Zhi Li, Yuzhou Zhao
BACKGROUND: The first case of treatment with en bloc right hemicolectomy with pancreatoduodenectomy (RHCPD) for locally advanced right-sided colon cancer (LARCC) invading the pancreas, duodenum, or other organs, was reported in 1953 by Van Prohaska. Right-sided colon cancers invading the pancreas and duodenum are rare. Surgery can be technically challenging, with unclear oncologic consequences, hence there are few reports on the clinical outcomes and factors associated with survival in this patient cohort...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38482229/neuroinflammation-in-the-paraventricular-nucleus-of-the-hypothalamus-precipitates-visceral-pain-induced-by-pancreatic-cancer-in-mice
#5
JOURNAL ARTICLE
Ning-Ning Ji, Zhi-Yan Li, Shuang Cao, Bei Pei, Chen-Yu Jin, Yi-Fan Li, Peng Mao, Hong Jiang, Bi-Fa Fan, Ming Xia
BACKGROUND: Given the pivotal role of neuroinflammation in chronic pain and that the paraventricular nucleus of the hypothalamus (PVN) is a crucial brain region involved in visceral pain regulation, we sought to investigate whether the targeted modulation of microglia and astrocytes in the PVN could ameliorate pancreatic cancer-induced visceral pain (PCVP) in mice. METHODS: Using a mouse model of PCVP, achieved by tumor cell injection at the head of the pancreas, we measure the number of glial cells, and at the same time we employed minocycline to inhibit microglia and chemogenetic methods to suppress astrocytes in order to investigate the respective roles of microglia and astrocytes within the PVN in PCVP...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38481922/extranodal-anaplastic-large-cell-lymphoma-involving-the-pancreas-a-rare-presentation
#6
Haifa N Alsaleem, Ahmed S Almuzaini, Khaled Alnafisah, Nawaf Almutairi, Ammar M ALAmmari, Ahmed S AlOmar
Anaplastic large-cell lymphoma (ALCL) is a subtype of T-cell lymphoma. This disease mainly affects lymph nodes, although extranodal sites may also be involved. Lymphoma in the pancreas is a rare clinical entity whether it manifests as primary or extranodal involvement. We discuss an unusual case of a 29-year-old male patient who presented with epigastric pain and a right neck mass. The patient's symptoms, physical examination, and laboratory tests prompted further investigation using imaging modalities such as CT, MRI, and endoscopic ultrasound, which revealed the presence of soft tissue masses in the right supraclavicular region and an ill-defined lesion within the pancreatic head...
February 2024: Curēus
https://read.qxmd.com/read/38480561/solid-pseudopapillary-tumor-of-the-pancreas-is-enucleation-safe
#7
JOURNAL ARTICLE
Oscar Salirrosas, Eduardo A Vega, Elena Panettieri, Hamed Harandi, Olga Kozyreva, Shree Ghanta, Claudius Conrad
BACKGROUND: While solid pseudopapillary tumor (SPT) of the pancreas are oncologically low-risk tumors, their resection with pancreaticoduodenectomy (PD) or partial pancreatectomy (PP) carries a significant risk for morbidity. To balance the favorable prognosis with the surgical morbidity of pancreas resection, this study explores the oncologic safety of enucleation (EN). PATIENTS AND METHODS: The National Cancer Database (NCDB) was queried for resected SPT from January 2004 through December 2020...
March 13, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38480109/cadmium-in-biological-samples-and-site-specific-cancer-risk-and-mortality-a-systematic-review-of-original-articles-and-meta-analyses
#8
REVIEW
Alice Fanfani, Sophia Papini, Emma Bortolotti, Giulia Vagnoni, Calogero Saieva, Guglielmo Bonaccorsi, Saverio Caini
BACKGROUND: Cadmium (Cd) is classified as a class 1 carcinogen by the IARC, yet uncertainty persists regarding the total burden of cancer (incidence and mortality) caused by exposure to it, due to the still limited evidence with regard to its aetiological role in cancer at several body sites. OBJECTIVES AND METHODS: We searched PubMed and EMBASE for meta-analyses and original articles published by February 1st, 2024, that focused on the link between cadmium measured in biological samples (blood, urine, finger-/toe-nails, and hair) and site-specific cancer risk and mortality...
March 12, 2024: Cancer Epidemiology
https://read.qxmd.com/read/38480047/systematic-review-on-surveillance-for-non-resected-branch-duct-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#9
JOURNAL ARTICLE
Sayada Zartasha Kazmi, Hye-Sol Jung, Youngmin Han, Won-Gun Yun, Young Jae Cho, Mirang Lee, Wooil Kwon, Carlos Fernandez-Del Castillo, Marco Del Chiaro, Giovanni Marchegiani, Brian K P Goh, Susumu Hijioka, Shounak Majumder, Yousuke Nakai, Aesun Shin, Jin-Young Jang
BACKGROUND: The management of branch-duct type intraductal papillary mucinous neoplasms (BD-IPMN) varies in existing guidelines. This study investigated the optimal surveillance protocol and safe discontinuation of surveillance considering natural history in non-resected IPMN, by systematically reviewing the published literature. METHODS: This review was guided by PRISMA. Research questions were framed in PICO format "CQ1-1: Is size criteria helpful to determine surveillance period? CQ1-2: How often should surveillance be carried out? CQ1-3: When should surveillance be discontinued? CQ1-4: Is nomogram predicting malignancy useful during surveillance?"...
February 28, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38473411/study-international-multicentric-pancreatic-left-resections-simplr-does-surgical-approach-matter
#10
JOURNAL ARTICLE
Sara Acciuffi, Mohammed Abu Hilal, Clarissa Ferrari, Sara Al-Madhi, Marc-Anthony Chouillard, Nouredin Messaoudi, Roland S Croner, Andrew A Gumbs
BACKGROUND: Minimally invasive surgery is increasingly preferred for left-sided pancreatic resections. The SIMPLR study aims to compare open, laparoscopic, and robotic approaches using propensity score matching analysis. METHODS: This study included 258 patients with tumors of the left side of the pancreas who underwent surgery between 2016 and 2020 at three high-volume centers. The patients were divided into three groups based on their surgical approach and matched in a 1:1 ratio...
March 5, 2024: Cancers
https://read.qxmd.com/read/38473267/towards-a-simplified-and-cost-effective-diagnostic-algorithm-for-the-surveillance-of-intraductal-papillary-mucinous-neoplasms-ipmns-can-we-save-contrast-for-later
#11
REVIEW
Nicolò Brandi, Matteo Renzulli
The increased detection of pancreatic cysts in recent years has triggered extensive diagnostic investigations to clarify their potential risk of malignancy, resulting in a large number of patients undergoing numerous imaging follow-up studies for many years. Therefore, there is a growing need for optimization of the current surveillance protocol to reduce both healthcare costs and waiting lists, while still maintaining appropriate sensibility and specificity. Imaging is an essential tool for evaluating patients with intraductal papillary mucinous neoplasms (IPMNs) since it can assess several predictors for malignancy and thus guide further management recommendations...
February 23, 2024: Cancers
https://read.qxmd.com/read/38470548/molecular-classification-of-gastrointestinal-and-pancreatic-neuroendocrine-neoplasms-are-we-ready-for-that
#12
REVIEW
Silvia Uccella
In the last two decades, the increasing availability of technologies for molecular analyses has allowed an insight in the genomic alterations of neuroendocrine neoplasms (NEN) of the gastrointestinal tract and pancreas. This knowledge has confirmed, supported, and informed the pathological classification of NEN, clarifying the differences between neuroendocrine carcinomas (NEC) and neuroendocrine tumors (NET) and helping to define the G3 NET category. At the same time, the identification genomic alterations, in terms of gene mutation, structural abnormalities, and epigenetic changes differentially involved in the pathogenesis of NEC and NET has identified potential molecular targets for precision therapy...
March 12, 2024: Endocrine Pathology
https://read.qxmd.com/read/38469236/impact-of-oseltamivir-on-the-risk-of-cancer
#13
JOURNAL ARTICLE
Pei-Hua Chuang, Bor-Show Tzang, Chih-Chen Tzang, Chun-Ching Chiu, Chun-Yu Lin, Tsai-Ching Hsu
PURPOSE: Mounting evidence has revealed the anti-cancer activity of various anti-viral drugs. Oseltamivir phosphate (OP), namely Tamiflu® , is routinely used to combat influenza infections. Although evidence has indicated the anti-cancer effects of OP in vitro and in vivo , little information is known about the effect of OP use on cancers in humans. METHODS: A nationwide population-based cohort study involving 13,977,101 cases with 284,733 receiving OP was performed to examine the association between OP use and cancers using the National Health Insurance Research Database in Taiwan between 2009 and 2018...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38469229/solid-pseudopapillary-neoplasm-of-the-pancreas-a-retrospective-study-of-195-cases
#14
JOURNAL ARTICLE
Chang Fu, Xiaocong Li, Yongxin Wang, Chuangshi Wang, Hengwei Jin, Kai Liu, Hongji Xu
OBJECTIVE: Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare exocrine tumor of the pancreas. The aim of our study is to summarize the clinical features of SPN and to analyze the risk factors for malignant SPN. METHODS: From May 2013 to September 2022, patients who were pathologically confirmed to have SPN were retrospectively reviewed. Demographic data, clinical and pathological features, follow-up data were collected and analyzed. To investigate the factors influencing the benign or malignant nature of SPN, we employed logistic regression...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38466015/neurological-autoimmunity-in-patients-with-non-pulmonary-neuroendocrine-neoplasms-clinical-manifestations-and-neural-autoantibody-profiles
#15
JOURNAL ARTICLE
Georgios Mangioris, Thorvardur R Halfdanarson, Vanda A Lennon, Bryce K Chang, Divyanshu Dubey, P James B Dyck, Eoin P Flanagan, Andrew McKeon, John R Mills, Sean J Pittock, Anastasia Zekeridou
BACKGROUND AND PURPOSE: Paraneoplastic neurological autoimmunity is well described with small-cell lung cancer, but information is limited for other neuroendocrine neoplasms (NENs). METHODS: Adult patients with histopathologically confirmed non-pulmonary NENs, neurological autoimmunity within 5 years of NEN diagnosis, and neural antibody testing performed at the Mayo Clinic Neuroimmunology Laboratory (January 2008 to March 2023) were retrospectively identified...
March 11, 2024: European Journal of Neurology
https://read.qxmd.com/read/38464029/oncogenic-gnas-drives-a-gastric-pylorus-program-in-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#16
Vincent Quoc-Huy Trinh, Katherine E Ankenbauer, Jiayue Liu, Maelle Batardiere, H Carlo Maurer, Celina Copeland, Jahg Wong, Olivia Ben-Levy, Sabrina M Torbit, Brenda Jarvis, Frank Revetta, Sergey Ivanov, Nidhi Jyotsana, Yuki Makino, Amanda M Ruelas, Anna L Means, Anirban Maitra, Marcus C B Tan, Kathleen E DelGiorno
OBJECTIVE: Intraductal Papillary Mucinous Neoplasms (IPMNs) are cystic lesions and bona fide precursors for pancreatic ductal adenocarcinoma (PDAC). Recently, we showed that acinar to ductal metaplasia, an injury repair program, is characterized by a transcriptomic program similar to gastric spasmolytic polypeptide expressing metaplasia (SPEM), suggesting common mechanisms of reprogramming between the stomach and pancreas. The aims of this study were to assay IPMN for pyloric markers and to identify molecular drivers of this program...
February 28, 2024: bioRxiv
https://read.qxmd.com/read/38463732/microcystic-serous-cystadenoma-of-the-pancreas-causing-biliary-obstruction-a-case-report-and-review-of-the-literature
#17
Sydney Bland, William Thompson Iii
Cystic tumors account for 15% of pancreatic tumors. Of these, serous microcystic adenomas represent 1-2% of pancreatic exocrine neoplasms. While typically benign, a small percentage possess malignant potential. Given imaging improvements, serous cystadenomas are being identified more frequently. A 63-year-old female was admitted with complaints of jaundice and unintentional weight loss. Abdominal computed tomography scan showed a 16 cm obstructive pancreatic mass near the porta hepatis region. Endoscopic ultrasonography and fine needle aspiration biopsy indicated a large pancreatic head cystic mass favoring serous microcystadenoma causing biliary and some pyloric obstruction...
March 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38460151/multidisciplinary-approach-for-the-management-of-metastatic-poorly-differentiated-neuroendocrine-carcinoma-of-the-pancreas-a-case-report-of-an-exceptional-responder
#18
JOURNAL ARTICLE
Elizabeth S Nakasone, Hannah C Bustillos, Xianyong Gui, Eric Q Konnick, Jonathan G Sham, Stacey A Cohen
Poorly differentiated pancreatic neuroendocrine carcinomas (pNECs) are rare, highly aggressive neoplasms. Frequently metastatic at diagnosis, prognosis is poor with median overall survival estimated to be less than 1 year. Although multidisciplinary management, including systemic medications and locoregional therapies aimed at reducing and preventing symptoms caused by mass effect, is the mainstay of treatment for patients with metastatic well-differentiated pancreatic neuroendocrine tumors, rapid progression, organ dysfunction, and poor performance status often preclude initiation of even single-modality palliative chemotherapy for patients with metastatic pNEC, limiting the use of and recommendation for multidisciplinary management...
March 6, 2024: Pancreas
https://read.qxmd.com/read/38450737/does-the-duration-of-diabetes-increase-the-risk-of-cancer-a-nationwide-population-based-cohort-of-patients-with-new-onset-diabetes-and-a-matched-reference-cohort
#19
JOURNAL ARTICLE
Petrus Lohi, Anssi Auvinen, Leo Niskanen, Timo Partonen, Jari Haukka
Diabetes mellitus and cancer are both common health issues, but the correlation between these two diseases remains unclear. We investigated the association of cumulative exposure of diabetes mellitus as an indication of hyperglycemia in terms of disease duration on multiple cancer types. We hypothesized that the risk of cancer would increase over time after the onset of diabetes. The study population consisted of a population-based cohort of 398,708 people and it was constructed from the Finnish CARING project...
March 7, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38449999/inoperable-renal-malignant-glomus-tumor-the-answers-for-all-the-w-s
#20
JOURNAL ARTICLE
Pushkala Surianarayanan, Arun Ramdas Menon, Shriley Sundersingh, Anand Raja
Glomus tumor, arising from glomus bodies (specialized neurovascular structures involved in thermoregulation), commonly occurs in extremities and rarely in viscera. The spectrum of glomus tumors range from benign tumors to tumors with uncertain malignant potential to tumors of the malignant subtype. A vast majority of visceral glomus tumors are benign. Most common visceral tumors arise in the gastrointestinal tract. Glomus tumors of the kidney are a rare entity of which malignant glomus tumors are exceedingly rare...
2024: Journal of Kidney Cancer and VHL
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